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PR01727

Identifier
DNABINDINGHU  [View Relations]  [View Alignment]  
Accession
PR01727
No. of Motifs
3
Creation Date
20-MAY-2002
Title
Prokaryotic integration host factor signature 
Database References

PROSITE; PS00045 HISTONE_LIKE
BLOCKS; IPB000119
PFAM; PF00216 Bac_DNA_binding
INTERPRO; IPR000119
PDB; 1HUE
SCOP; 1HUE
CATH; 1HUE
Literature References
1. HAYAT, M.A. AND MANCARELLA, D.A.
Nucleoid proteins.
MICRON 26 461-480 (1995).
 
2. JAFFAR ALI, B.M., AMIT, R., BRASLAVSKY, I., OPPENHEIM, A.B., GILEAD, O. 
AND STAVANS, J.
Compaction of single DNA molecules induced by binding of integration host 
factor (IHF).
PROC.NAT.ACAD.SCI.U.S.A. 98 10658-10663 (2001).
 
3. PAINBENI, E., CAROFF, M. AND ROUVIERE-YANIV, J.
Alterations of the outer membrane composition in Escherichia coli lacking 
the histone-like protein HU.
PROC.NAT.ACAD.SCI.U.S.A. 94 6712-6717 (1997).
 
4. STINSON, M.W., MCLAUGHLIN, R., CHOI, S.H., JUAREZ, Z.E. AND BARNARD, J.
Streptococcal histone-like protein: primary structure of hlpA and protein
binding to lipoteichoic acid and epithelial cells.
INFECT.IMMUN. 66 259-265 (1998). 
 
5. ZHANG, L., IGNATOWSKI, T.A., SPENGLER, R.N., NOBLE, B. AND STINSON, M.W.
Streptococcal histone induces murine macrophages to produce interleukin-1 
and tumor necrosis factor alpha.
INFECT.IMMUN. 67 6473-6477 (1999).
 
6. VIS, H., MARIANI, M., VORGIAS, C.E., WILSON, K.S., KAPTEIN, R. AND 
BOELENS, R.
Solution structure of the HU protein from Bacillus stearothermophilus.
J.MOL.BIOL. 254 692-703 (1995).

Documentation
Nucleoid histone or histone-like DNA-binding proteins are found throughout 
both the eukaryotic and prokaryotic kingdoms. The main function of these 
moieties is to organise the host DNA and to control the expression of genes  
contained therein [1]. In bacteria, the histone-like family of proteins 
includes HU, H-NS, and the integration host factors (IHFs). Although not 
sequentially similar to eukaryotic histone proteins, the bacterial versions 
carry out the same process of introducing negative supercoiling into relaxed 
chromosomal DNA in the presence of topoisomerase I [1], and are named 
accordingly.
 
Intracellular levels of the different DNA-binding proteins change during 
bacterial cell growth, IHF increasing during stationary phase, and HU
increasing as exponential growth is achieved [2]. A study to determine the 
elasticity of host DNA bound to Escherichia coli IHF has shown that the 
protein plays a part in non-specific binding of nucleic acids, compacting 
the chromosome during stationary growth phase [2]. E.coli mutants lacking 
the HU gene exhibit a highly altered outer membrane structure that is 
extremely sensitive to detergents and antibiotics [3]. It is believed 
therefore that these histone-like proteins are essential for the survival
of pathogenic and commensal microbes inside the human host [3].
 
In several streptococcal species, the IHF and HU genes also play a 
role in virulence. A HU-homologue, termed Histone-Like Protein A (HlpA)
can bind specifically to heparan sulphate in the proteoglycan basement layers 
of host heart and kidney tissues [4]. Upon pathogen cell lysis at the site 
of infection, the released HlpA forms complexes with soluble lipoteichoic 
acid (LTA) from the ruptured bacterial cell membranes. These complexes form 
potent nephritotoxins, elicit a strong IL-1 and TNF-alpha response, and are 
connected with acute post-streptococcal glomerulonephritis and rheumatic 
fever [5].
 
The structure of the histone-like protein HU from Bacillus stearothermophilus
has been determined by NMR. The protein exists as a dimer, with a combined
molecular mass of 19.5kDa [6]. Two "beta-arms" function as the non-specific 
binding site for bacterial DNA. 
 
DNABINDINGHU is a 3-element fingerprint that provides a signature for 
the prokaryotic integration host factor family. The fingerprint was derived
from an initial alignment of 8 sequences: the motifs were drawn from 
conserved regions spanning the C-terminal portion of the alignment (~50 
amino acids) - motif 1 spans beta-strand 1; motif 2 encodes strands 2 and 3; 
and motif 3 encompasses strand 4 and alpha-helix 3. Two iterations on
SPTR40_20f were required to reach convergence, at which point a true set 
comprising 109 sequences was identified. Several partial matches were also
found, all of which are prokaryotic histone-like proteins that fail to
match one of the motifs. 
Summary Information
 109 codes involving  3 elements
19 codes involving 2 elements
Composite Feature Index
3109109109
217165
123
True Positives
DBH1_BACHD    DBH1_BACSU    DBH1_RHILE    DBH2_BACHD    
DBH2_BACSU DBH2_STRCO DBH5_RHILE DBHA_AERHY
DBHA_BURPS DBHA_ECOLI DBHA_PSEAE DBHA_SALTY
DBHA_SERMA DBHA_VIBCH DBHA_VIBPR DBHB_ECOLI
DBHB_NEIMA DBHB_PSEAE DBHB_PSEFL DBHB_SALTY
DBHB_SERMA DBHB_VIBCH DBHC_NEIMA DBH_ANASP
DBH_BACST DBH_BORAD DBH_BORAF DBH_BORBU
DBH_BORGA DBH_BORJA DBH_BORPR DBH_BORTU
DBH_BUCAI DBH_CAMJE DBH_CLOPA DBH_HAEIN
DBH_LACLA DBH_MYCBO DBH_MYCLE DBH_MYCSM
DBH_MYCTU DBH_PASMU DBH_RHIME DBH_RICPR
DBH_STRDO DBH_STRGN DBH_STRMU DBH_STRPY
DBH_STRTR DBH_SYNY3 DBH_THEMA DBH_THETH
DBH_XYLFA IHFA_BUCAI IHFA_ECOLI IHFA_ERWCH
IHFA_HAEIN IHFA_PASHA IHFA_PASMU IHFA_PSEAE
IHFA_PSEPU IHFA_SALTY IHFA_SERMA IHFA_VIBCH
IHFA_XANCA IHFA_XYLFA IHFA_YERPS IHFB_AGRTU
IHFB_BUCAI IHFB_BUCAP IHFB_ECOLI IHFB_ERWCH
IHFB_HAEIN IHFB_NEIMA IHFB_PASHA IHFB_PASMU
IHFB_PSEAE IHFB_PSEPU IHFB_RHOCA IHFB_RHOSH
IHFB_SERMA IHFB_VIBCH IHFB_XYLFA O85384
Q8XFX6 Q8XHK4 Q8XU35 Q8XWF3
Q8XYP4 Q8Y0Y3 Q8YET3 Q8YHC5
Q8ZAR0 Q8ZC68 Q8ZDX2 Q8ZGB1
Q92A74 Q92SJ7 Q93TM2 Q93TM3
Q97EA3 Q97QT6 Q982V3 Q98GS0
Q99U17 Q9A2H5 Q9A5W6 Q9HX76
Q9R336
True Positive Partials
Codes involving 2 elements
DBH1_STRCO DBH_CAUCR DBH_DEIRA DBH_GUITH
DBH_HELPJ DBH_HELPY IHFA_MYXXA IHFA_NEIMA
IHFA_RHOCA IHFA_ZYMMO Q44357 Q8XZ23
Q8YGI0 Q92QT3 Q982Z7 Q9A8I3
Q9CH59 Q9R6F7 TF1_BPSP1
Sequence Titles
DBH1_BACHD  DNA-binding protein HU-1 - Bacillus halodurans. 
DBH1_BACSU DNA-binding protein HU 1 (DNA-binding protein II) (HB) - Bacillus subtilis.
DBH1_RHILE DNA-binding protein HRL18 - Rhizobium leguminosarum, and Agrobacterium tumefaciens.
DBH2_BACHD DNA-binding protein HU-1 - Bacillus halodurans.
DBH2_BACSU DNA-binding protein HU 2 - Bacillus subtilis, and Bacteriophage SPBc2.
DBH2_STRCO DNA-binding protein HU 2 - Streptomyces coelicolor, and Streptomyces lividans.
DBH5_RHILE DNA-binding protein HRL53 (Px) (HU-like protein) - Rhizobium leguminosarum.
DBHA_AERHY DNA-binding protein HU-alpha - Aeromonas hydrophila.
DBHA_BURPS DNA-binding protein HU-alpha - Burkholderia pseudomallei (Pseudomonas pseudomallei).
DBHA_ECOLI DNA-binding protein HU-alpha (NS2) (HU-2) - Escherichia coli, and Escherichia coli O157:H7.
DBHA_PSEAE DNA-binding protein HU-alpha - Pseudomonas aeruginosa.
DBHA_SALTY DNA-binding protein HU-alpha (NS2) (HU-2) - Salmonella typhimurium.
DBHA_SERMA DNA-binding protein HU-alpha (NS2) (HU-2) - Serratia marcescens.
DBHA_VIBCH DNA-binding protein HU-alpha - Vibrio cholerae.
DBHA_VIBPR DNA-binding protein HU-alpha - Vibrio proteolyticus (Aeromonas proteolytica).
DBHB_ECOLI DNA-binding protein HU-beta (NS1) (HU-1) - Escherichia coli, and Escherichia coli O157:H7.
DBHB_NEIMA DNA-binding protein HU-beta - Neisseria meningitidis (serogroup A), and Neisseria meningitidis (serogroup B).
DBHB_PSEAE DNA-binding protein HU-beta - Pseudomonas aeruginosa.
DBHB_PSEFL DNA-binding protein HU-beta - Pseudomonas fluorescens.
DBHB_SALTY DNA-binding protein HU-beta (NS1) (HU-1) - Salmonella typhimurium.
DBHB_SERMA DNA-binding protein HU-beta (NS1) (HU-1) - Serratia marcescens.
DBHB_VIBCH DNA-binding protein HU-beta - Vibrio cholerae.
DBHC_NEIMA DNA-binding protein HU-beta 2 - Neisseria meningitidis (serogroup A).
DBH_ANASP DNA-binding protein HU - Anabaena sp. (strain PCC 7120).
DBH_BACST DNA-binding protein HU (DNA-binding protein II) (HB) - Bacillus stearothermophilus, Bacillus caldolyticus, and Bacillus caldotenax.
DBH_BORAD DNA-binding protein HBBU - Borrelia andersonii.
DBH_BORAF DNA-binding protein HBBU - Borrelia afzelii.
DBH_BORBU DNA-binding protein HU (HBBU) - Borrelia burgdorferi (Lyme disease spirochete).
DBH_BORGA DNA-binding protein HBBU - Borrelia garinii.
DBH_BORJA DNA-binding protein HBBU - Borrelia japonica.
DBH_BORPR DNA-binding protein HBBU - Borrelia parkeri.
DBH_BORTU DNA-binding protein HBBU - Borrelia turicatae.
DBH_BUCAI DNA-binding protein HU - Buchnera aphidicola (subsp. Acyrthosiphon pisum) (Acyrthosiphon pisum symbiotic bacterium).
DBH_CAMJE DNA-binding protein HU (HCj) - Campylobacter jejuni.
DBH_CLOPA DNA-binding protein HU - Clostridium pasteurianum.
DBH_HAEIN DNA-binding protein HU - Haemophilus influenzae.
DBH_LACLA DNA-binding protein HU - Lactococcus lactis (subsp. lactis) (Streptococcus lactis).
DBH_MYCBO DNA-binding protein HU homolog (Histone-like protein) (Hlp) - Mycobacterium bovis.
DBH_MYCLE DNA-binding protein HU homolog (Histone-like protein) (Hlp) (21-kDa laminin-2-binding protein) - Mycobacterium leprae.
DBH_MYCSM DNA-binding protein HU homolog (Histone-like protein) (Hlp) - Mycobacterium smegmatis.
DBH_MYCTU DNA-binding protein HU homolog (Histone-like protein) (Hlp) (21-kDa laminin-2-binding protein) - Mycobacterium tuberculosis.
DBH_PASMU DNA-binding protein HU - Pasteurella multocida.
DBH_RHIME DNA-binding protein HRm - Rhizobium meliloti (Sinorhizobium meliloti).
DBH_RICPR DNA-binding protein HU - Rickettsia prowazekii.
DBH_STRDO DNA-binding protein HU - Streptococcus downei (Streptococcus sobrinus).
DBH_STRGN DNA-binding protein HU - Streptococcus gordonii.
DBH_STRMU DNA-binding protein HU - Streptococcus mutans.
DBH_STRPY DNA-binding protein HU - Streptococcus pyogenes.
DBH_STRTR DNA-binding protein HU - Streptococcus thermophilus.
DBH_SYNY3 DNA-binding protein HU - Synechocystis sp. (strain PCC 6803).
DBH_THEMA DNA-binding protein HU - Thermotoga maritima.
DBH_THETH DNA-binding protein HU (DNA-binding protein II) - Thermus aquaticus (subsp. thermophilus).
DBH_XYLFA DNA-binding protein HU - Xylella fastidiosa.
IHFA_BUCAI Integration host factor alpha-subunit (IHF-alpha) - Buchnera aphidicola (subsp. Acyrthosiphon pisum) (Acyrthosiphon pisum symbiotic bacterium).
IHFA_ECOLI Integration host factor alpha-subunit (IHF-alpha) - Escherichia coli, and Escherichia coli O157:H7.
IHFA_ERWCH Integration host factor alpha-subunit (IHF-alpha) - Erwinia chrysanthemi.
IHFA_HAEIN Integration host factor alpha-subunit (IHF-alpha) - Haemophilus influenzae.
IHFA_PASHA Integration host factor alpha-subunit (IHF-alpha) - Pasteurella haemolytica.
IHFA_PASMU Integration host factor alpha-subunit (IHF-alpha) - Pasteurella multocida.
IHFA_PSEAE Integration host factor alpha-subunit (IHF-alpha) - Pseudomonas aeruginosa.
IHFA_PSEPU Integration host factor alpha-subunit (IHF-alpha) - Pseudomonas putida.
IHFA_SALTY Integration host factor alpha-subunit (IHF-alpha) - Salmonella typhimurium.
IHFA_SERMA Integration host factor alpha-subunit (IHF-alpha) - Serratia marcescens.
IHFA_VIBCH Integration host factor alpha-subunit (IHF-alpha) - Vibrio cholerae.
IHFA_XANCA Integration host factor alpha-subunit (IHF-alpha) - Xanthomonas campestris.
IHFA_XYLFA Integration host factor alpha-subunit (IHF-alpha) - Xylella fastidiosa.
IHFA_YERPS Integration host factor alpha-subunit (IHF-alpha) - Yersinia pseudotuberculosis.
IHFB_AGRTU Integration host factor beta-subunit (IHF-beta) - Agrobacterium tumefaciens.
IHFB_BUCAI Integration host factor beta-subunit (IHF-beta) - Buchnera aphidicola (subsp. Acyrthosiphon pisum) (Acyrthosiphon pisum symbiotic bacterium).
IHFB_BUCAP Integration host factor beta-subunit (IHF-beta) - Buchnera aphidicola (subsp. Schizaphis graminum).
IHFB_ECOLI Integration host factor beta-subunit (IHF-beta) - Escherichia coli, and Escherichia coli O157:H7.
IHFB_ERWCH Integration host factor beta-subunit (IHF-beta) - Erwinia chrysanthemi.
IHFB_HAEIN Integration host factor beta-subunit (IHF-beta) - Haemophilus influenzae.
IHFB_NEIMA Integration host factor beta-subunit (IHF-beta) - Neisseria meningitidis (serogroup A), Neisseria meningitidis (serogroup B), and Neisseria gonorrhoeae.
IHFB_PASHA Integration host factor beta-subunit (IHF-beta) - Pasteurella haemolytica.
IHFB_PASMU Integration host factor beta-subunit (IHF-beta) - Pasteurella multocida.
IHFB_PSEAE Integration host factor beta-subunit (IHF-beta) - Pseudomonas aeruginosa.
IHFB_PSEPU Integration host factor beta-subunit (IHF-beta) - Pseudomonas putida.
IHFB_RHOCA Integration host factor beta-subunit (IHF-beta) - Rhodobacter capsulatus (Rhodopseudomonas capsulata).
IHFB_RHOSH Integration host factor beta-subunit (IHF-beta) - Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides).
IHFB_SERMA Integration host factor beta-subunit (IHF-beta) - Serratia marcescens.
IHFB_VIBCH Integration host factor beta-subunit (IHF-beta) - Vibrio cholerae.
IHFB_XYLFA Integration host factor beta-subunit (IHF-beta) - Xylella fastidiosa.
O85384 HISTONE-LIKE PROTEIN HLM - Listeria monocytogenes.
Q8XFX6 INTEGRATION HOST FACTOR (IHF), BETA SUBUNIT, SITE-SPECIFIC RECOMBINATION (INTEGRATION HOST FACTOR BETA-SUBUNIT) (IHF-BETA) - Salmonella typhimurium, and Salmonella typhi.
Q8XHK4 PROBABLE DNA BINDING PROTEIN - Clostridium perfringens.
Q8XU35 PROBABLE HISTONE-LIKE DNA-BINDING PROTEIN HU-BETA (NS1) - Ralstonia solanacearum (Pseudomonas solanacearum).
Q8XWF3 PROBABLE DNA-BINDING PROTEIN HU-BETA (NS1) (HU-1) - Ralstonia solanacearum (Pseudomonas solanacearum).
Q8XYP4 PROBABLE DNA-BINDING PROTEIN HU-BETA - Ralstonia solanacearum (Pseudomonas solanacearum).
Q8Y0Y3 PUTATIVE INTEGRATION HOST FACTOR BETA-SUBUNIT (IHF-BETA) PROTEIN - Ralstonia solanacearum (Pseudomonas solanacearum).
Q8YET3 INTEGRATION HOST FACTOR BETA-SUBUNIT - Brucella melitensis.
Q8YHC5 DNA-BINDING PROTEIN HU-ALPHA - Brucella melitensis.
Q8ZAR0 DNA-BINDING PROTEIN HU-ALPHA - Yersinia pestis.
Q8ZC68 DNA-BINDING PROTEIN HU-BETA - Yersinia pestis.
Q8ZDX2 INTEGRATION HOST FACTOR ALPHA-SUBUNIT - Yersinia pestis.
Q8ZGB1 INTEGRATION HOST FACTOR BETA-SUBUNIT - Yersinia pestis.
Q92A74 HUP PROTEIN - Listeria monocytogenes, and Listeria innocua.
Q92SJ7 PROBABLE INTEGRATION HOST FACTOR BETA-SUBUNIT PROTEIN - Rhizobium meliloti (Sinorhizobium meliloti).
Q93TM2 HISTONE-LIKE PROTEIN HU FORM N - Pseudomonas putida.
Q93TM3 HISTONE-LIKE PROTEIN HU FORM B - Pseudomonas putida.
Q97EA3 DNA BINDING PROTEIN HU - Clostridium acetobutylicum.
Q97QT6 DNA-BINDING PROTEIN HU - Streptococcus pneumoniae.
Q982V3 DNA-BINDING PROTEIN, HRM - Rhizobium loti (Mesorhizobium loti).
Q98GS0 INTEGRATION HOST FACTOR BETA CHAIN - Rhizobium loti (Mesorhizobium loti).
Q99U17 DNA-BINDING PROTEIN II (HB) - Staphylococcus aureus (strain Mu50 / ATCC 700699), and Staphylococcus aureus (strain N315).
Q9A2H5 INTEGRATION HOST FACTOR BETA SUBUNIT - Caulobacter crescentus.
Q9A5W6 DNA-BINDING PROTEIN HU - Caulobacter crescentus.
Q9HX76 PROBABLE DNA BINDING PROTEIN (HISTONE-LIKE PROTEIN HU FORM N) - Pseudomonas aeruginosa.
Q9R336 DNA-BINDING PROTEIN HU-BETA - Bordetella pertussis, and Bordetella bronchiseptica (Alcaligenes bronchisepticus).

DBH1_STRCO DNA-binding protein HU 1 (HSl) - Streptomyces coelicolor, and Streptomyces lividans.
DBH_CAUCR DNA-binding protein HU - Caulobacter crescentus.
DBH_DEIRA DNA-binding protein HU - Deinococcus radiodurans.
DBH_GUITH DNA-binding protein HU homolog (Histone-like protein) - Guillardia theta (Cryptomonas phi).
DBH_HELPJ DNA-binding protein HU - Helicobacter pylori J99 (Campylobacter pylori J99).
DBH_HELPY DNA-binding protein HU - Helicobacter pylori (Campylobacter pylori).
IHFA_MYXXA Integration host factor alpha-subunit (IHF-alpha) - Myxococcus xanthus.
IHFA_NEIMA Integration host factor alpha-subunit (IHF-alpha) - Neisseria meningitidis (serogroup A), and Neisseria meningitidis (serogroup B).
IHFA_RHOCA Integration host factor alpha-subunit (IHF-alpha) - Rhodobacter capsulatus (Rhodopseudomonas capsulata).
IHFA_ZYMMO Integration host factor alpha-subunit (IHF-alpha) - Zymomonas mobilis.
Q44357 HUPT - Agrobacterium tumefaciens.
Q8XZ23 PROBABLE INTEGRATION HOST FACTOR ALPHA-SUBUNIT (IHF-ALPHA) PROTEIN - Ralstonia solanacearum (Pseudomonas solanacearum).
Q8YGI0 INTEGRATION HOST FACTOR ALPHA-SUBUNIT - Brucella melitensis.
Q92QT3 PROBABLE INTEGRATION HOST FACTOR ALPHA-SUBUNIT PROTEIN - Rhizobium meliloti (Sinorhizobium meliloti).
Q982Z7 INTEGRATION HOST FACTOR ALPHA SUBUNIT - Rhizobium loti (Mesorhizobium loti).
Q9A8I3 INTEGRATION HOST FACTOR ALPHA-SUBUNIT - Caulobacter crescentus.
Q9CH59 HU-LIKE DNA-BINDING PROTEIN (HLLB) - Lactococcus lactis (subsp. lactis) (Streptococcus lactis), and Lactococcus lactis.
Q9R6F7 TIORF102 PROTEIN - Agrobacterium tumefaciens.
TF1_BPSP1 Transcription factor 1 - Bacteriophage SP01.
Scan History
SPTR40_20f 2  200  NSINGLE    
Initial Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
EKVQLIGFGNFEVRER DBH_STRPY 41 41 -
EKVQLIGFGNFEVRER DBH_STRGN 41 41 -
DKIQLIGFGNFEVRER DBH1_BACSU 40 40 -
DAVQLVGFGTFKVNHR DBHA_ECOLI 40 40 -
EPVQLIGFGTFKVNER DBH_HAEIN 40 40 -
DQVQLIGFGTFKVNHR DBHA_VIBPR 40 40 -
DSVTLVGFGTFLQRHR DBHA_PSEAE 40 40 -
DSISFIGFGTFSTQER DBH_CAMJE 40 40 -

Motif 2 width=14
Element Seqn Id St Int Rpt
RKGRNPQTGAEIEI DBH_STRPY 59 2 -
RKGRNPQTGKETKI DBH_STRGN 59 2 -
RKGRNPQTGEEIEI DBH1_BACSU 58 2 -
RTGRNPQTGKEIKI DBHA_ECOLI 58 2 -
RTGRNPQTGAEIQI DBH_HAEIN 58 2 -
RTGRNPKTGAEIQI DBHA_VIBPR 58 2 -
RTGKNPQTGQPVKI DBHA_PSEAE 58 2 -
REARVPSTGKTIKV DBH_CAMJE 58 2 -

Motif 3 width=15
Element Seqn Id St Int Rpt
SKVPAFKAGKALKDA DBH_STRPY 75 2 -
SKVPAFKAGKALKDA DBH_STRGN 75 2 -
SKVPAFKPGKALKDA DBH1_BACSU 74 2 -
ANVPAFVSGKALKDA DBHA_ECOLI 74 2 -
SKVPAFVSGKALKDA DBH_HAEIN 74 2 -
ANVPAFVAGKALKDA DBHA_VIBPR 74 2 -
SNTVAFKPGKALRDA DBHA_PSEAE 74 2 -
TRVAKFKVGKNLKEA DBH_CAMJE 74 2 -
Final Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
EKVQLIGFGNFEVRER DBH_STRMU 41 41 -
EKVQLIGFGNFEVRER DBH_STRDO 41 41 -
EKVQLIGFGNFEVRER Q99U17 40 40 -
EKVQLIGFGNFEVRER DBH_STRPY 41 41 -
EKVQLIGFGNFEVRER DBH_STRGN 41 41 -
EKVQLIGFGNFEVRER DBH_STRTR 41 41 -
DKVQLIGFGNFEVRER DBH_BACST 40 40 -
EKVQLIGFGNFEVRER Q97QT6 41 41 -
DQVALVGFGTFSVRTR DBHB_VIBCH 40 40 -
DDVALVGFGSFTVRER DBHB_SERMA 40 40 -
DKIQLIGFGNFEVRER DBH1_BACSU 40 40 -
DSVQLIGFGNFEVRER DBH2_BACHD 40 40 -
EPVQLIGFGTFKVNSR DBH_PASMU 40 40 -
DQVQLIGFGTFKVNHR DBHA_VIBCH 40 40 -
DAVQLVGFGTFKVNHR DBHA_ECOLI 40 40 -
DAVQLVGFGTFKVNHR DBHA_SERMA 40 40 -
DAVQLVGFGTFKVNHR DBHA_SALTY 40 40 -
EKVQLIGFGTFETRER DBH_LACLA 41 41 -
DPVQLVGFGTFKVNHR Q8ZAR0 40 40 -
DDVALVGFGTFAVKER DBHB_ECOLI 40 40 -
DDVALVGFGTFAVKER DBHB_SALTY 40 40 -
DDVVLVGFGTFSVKER Q93TM3 40 40 -
EPVQLIGFGTFKVNER DBH_HAEIN 40 40 -
DDVALVGFGTFAVRER Q8ZC68 40 40 -
GKVQLVGFGSFEVRER DBH1_BACHD 40 40 -
DAVQLVGFGTFKVNHR DBHA_AERHY 40 40 -
DSVVLVGFGTFAVKER DBHB_PSEAE 40 40 -
DQVQLIGFGTFKVNHR DBHA_VIBPR 40 40 -
EKVQLIGFGNFEVRER Q92A74 41 41 -
GTVTLVGFGTFAVSAR Q9R336 40 40 -
EKVSIPGFGTFEVRER DBH2_BACSU 40 40 -
GSVTLVGFGTFLVGQR Q8XYP4 40 40 -
DTVTLVGFGTFYVGER DBHB_NEIMA 40 40 -
DSVVLVGFGTFSVTDR DBHB_PSEFL 40 40 -
ESVQIVGFGTFKVNLR DBH_BUCAI 40 40 -
KLLHLLGFGNFEVRER O85384 33 33 -
DSVTLVGFGTFQVRPR DBH_XYLFA 40 40 -
GDVRLVGFGNFTVSKR Q982V3 40 40 -
DSVQLIGFGSFGSGKR DBHA_BURPS 40 40 -
EKVQLVGFGTFETRER DBH_CLOPA 40 40 -
EEVRLPGFGVFSVSHR Q8YHC5 42 42 -
EKVTLVGFGSFEARER DBH_SYNY3 46 46 -
DKVQLVGFGTFETRVR Q8XHK4 40 40 -
DSVTLVGFGTFLQRHR DBHA_PSEAE 40 40 -
EKVQLVGFGTFETRER Q97EA3 40 40 -
GDIRLVGFGNFSVSRR DBH_RHIME 40 40 -
SKVQLTGFGTFEVRKR DBH_THETH 45 45 -
GDIRLAGFGSFSVSRR DBH1_RHILE 40 40 -
EKVQIVGFGSFEVRKA DBH_THEMA 40 40 -
NDVTLVGFGTFHAAQS DBHC_NEIMA 40 40 -
GTITLVGFGSFSSGKR Q8XWF3 41 41 -
GDIRLAGFGSFTVSHR DBH5_RHILE 40 40 -
DRVELRGFGAFSVKAR IHFB_RHOSH 41 41 -
DTVSLIGFGTFSQGER Q8XU35 41 41 -
DKVTLVGFGSFESRER DBH_ANASP 40 40 -
DRVELRGFGAFSVKKR IHFB_RHOCA 41 41 -
NRVELRGFGAFSVKNR Q8YET3 48 48 -
NRVELRGFGAFSVKNR Q98GS0 41 41 -
HNVNLTGFGSFEIHHR DBH_RICPR 49 49 -
GRVELRGFGALSVRSR Q9A2H5 41 41 -
EEVSIPGFGKFKVQAK Q9A5W6 41 41 -
DRVEVRGFGSFSLHHR IHFB_HAEIN 41 41 -
NRVELRGFGAFSVKNR Q92SJ7 41 41 -
EQVKLSGFGNFDLRDK IHFA_PSEAE 43 43 -
EQVKLSGFGNFDLRDK IHFA_PSEPU 43 43 -
DSISFIGFGTFSTQER DBH_CAMJE 40 40 -
GEITLPGIGKLKVSER Q9HX76 42 42 -
RQVKLSGFGNFDLRRK IHFA_XANCA 42 42 -
EDVKLSGFGNFELRDK IHFA_PASMU 42 42 -
KRIEIRGFGTFSLHYR IHFB_BUCAP 41 41 -
RQIKLSGFGNFELRCK IHFA_XYLFA 42 42 -
KRIEIRGFGSFSLHYR IHFB_BUCAI 41 41 -
DSVTITGFGVFEQRRR DBH_MYCBO 40 40 -
DSVTITGFGVFEQRRR DBH_MYCTU 40 40 -
DSVTITGFGVFEQRRR DBH_MYCSM 40 40 -
DSVTITGFGVFEQRRR DBH_MYCLE 40 40 -
EEVKLSGFGNFSLREK IHFA_PASHA 43 43 -
EQVKLSGFGNFGLRDK IHFA_SALTY 42 42 -
EQVKLSGFGNFDLRDK IHFA_VIBCH 42 42 -
DRIEIRGFGSFSLHYR IHFB_ERWCH 41 41 -
ERIEIRGFGSFSLHYR IHFB_ECOLI 41 41 -
ERIEIRGFGSFSLHYR Q8XFX6 41 41 -
EAVKLSGFGNFQIKKK IHFA_BUCAI 42 42 -
EQVKLSGFGNFDLRDK IHFA_ECOLI 42 42 -
EQVKLSGFGNFDLRDK Q8ZDX2 42 42 -
EQVKLSGFGNFDLRDK IHFA_YERPS 42 42 -
EQVKLSGFGNFDLRDK IHFA_SERMA 42 42 -
EQVKLSGFGNFDLRDK IHFA_ERWCH 42 42 -
AEITLPGIGKLKVSER Q93TM2 42 42 -
ERIEVRGFGSFSLHYR IHFB_PASHA 41 41 -
DRIEIRGFGSFSLHYR IHFB_PSEPU 41 41 -
ERIEIRGFGSFSLHYR IHFB_SERMA 41 41 -
ERIEIRGFGSFSLHYR Q8ZGB1 41 41 -
KRIEVRGFGSFSLHYR IHFB_PASMU 41 41 -
DRIEIRGFGSFSLHYR IHFB_PSEAE 41 41 -
HRIEIRGFGSFGLNRR Q8Y0Y3 41 41 -
QDVKLSGFGNFELRDK IHFA_HAEIN 43 43 -
ERIEIRGFGSFSLHYR IHFB_VIBCH 41 41 -
DRIEIRGFGSFSLHYR IHFB_XYLFA 41 41 -
QRIEIRGFGSFDLNHR IHFB_NEIMA 46 46 -
DRVSVTGFGSFEKVDR DBH2_STRCO 39 39 -
ERVDIRSFGTFVVRHR IHFB_AGRTU 41 41 -
NVIEFRSFGTFEVRKR DBH_BORAD 53 53 -
NVIEFRSFGTFEVRKR DBH_BORJA 53 53 -
NVIEFRSFGTFEVRKR DBH_BORGA 53 53 -
NVIEFRSFGTFEVRKR DBH_BORBU 53 53 -
NVIEFRSFGTFEVRKR DBH_BORAF 53 53 -
NVIEFRSFGTFELRKR DBH_BORPR 53 53 -
NVIEFRSFGTFELRKR DBH_BORTU 53 53 -

Motif 2 width=14
Element Seqn Id St Int Rpt
RKGRNPQTGEEIKI DBH_STRMU 59 2 -
RKGRNPQTGAEIKI DBH_STRDO 59 2 -
RKGRNPQTGKEIDI Q99U17 58 2 -
RKGRNPQTGAEIEI DBH_STRPY 59 2 -
RKGRNPQTGKETKI DBH_STRGN 59 2 -
RQGRNPQTGETISI DBH_STRTR 59 2 -
RKGRNPQTGEEMEI DBH_BACST 58 2 -
RKGRNPQTGKEMTI Q97QT6 59 2 -
RTGRNPKTGEEIKI DBHB_VIBCH 58 2 -
RTGRNPQTGKEIKI DBHB_SERMA 58 2 -
RKGRNPQTGEEIEI DBH1_BACSU 58 2 -
RKGRNPQTGEEIDI DBH2_BACHD 58 2 -
RTGRNPQTGAEIKI DBH_PASMU 58 2 -
RTGRNPKTGEEIKI DBHA_VIBCH 58 2 -
RTGRNPQTGKEIKI DBHA_ECOLI 58 2 -
RTGRNPQTGKEIKI DBHA_SERMA 58 2 -
RTGRNPQTGKEIKI DBHA_SALTY 58 2 -
REGRNPQTGEAIKI DBH_LACLA 59 2 -
RTGRNPQTGKEIKI Q8ZAR0 58 2 -
RTGRNPQTGKEITI DBHB_ECOLI 58 2 -
RTGRNPQTGKEITI DBHB_SALTY 58 2 -
RTGRNPQTGKAIKI Q93TM3 58 2 -
RTGRNPQTGAEIQI DBH_HAEIN 58 2 -
RTGRNPQTGKEISI Q8ZC68 58 2 -
RKGRNPQTGEEIEI DBH1_BACHD 58 2 -
RTGRNPQTGKEIQI DBHA_AERHY 58 2 -
RTGRNPQTGKPIKI DBHB_PSEAE 58 2 -
RTGRNPKTGAEIQI DBHA_VIBPR 58 2 -
RKGRNPRTKEEIDI Q92A74 59 2 -
RTGRNPRTGETIKI Q9R336 58 2 -
RKGRNPQTGEEIDI DBH2_BACSU 58 2 -
RAGRNPRTGATIKI Q8XYP4 58 2 -
RQGRNPKTGEPLTI DBHB_NEIMA 58 2 -
RIGRNPQTGKTLEI DBHB_PSEFL 58 2 -
RTGRNPQTGKEIQI DBH_BUCAI 58 2 -
RKGRNPATKEEIDI O85384 51 2 -
RPGRNPKSGELIMI DBH_XYLFA 58 2 -
STGRNPQTGAEVKI Q982V3 58 2 -
RTGRNPKTGETIKI DBHA_BURPS 58 2 -
REGRNPRTKEVINI DBH_CLOPA 58 2 -
STGRNPSTGKEVAI Q8YHC5 60 2 -
REGRNPKTGDKMLI DBH_SYNY3 64 2 -
REGRNPRTKEVIKI Q8XHK4 58 2 -
RTGKNPQTGQPVKI DBHA_PSEAE 58 2 -
RKGRNPRSKEEIVI Q97EA3 58 2 -
SKGRNPSTGAEVDI DBH_RHIME 58 2 -
RTGVKPGTKEKIKI DBH_THETH 63 2 -
SKGRNPSTGAEVDI DBH1_RHILE 58 2 -
RKGVNPQTRKPITI DBH_THEMA 58 2 -
RQGRNPKTGEPLTI DBHC_NEIMA 58 2 -
RTGRNPRTGEAIKI Q8XWF3 59 2 -
TKGRNPSTGAEVDI DBH5_RHILE 58 2 -
RVGRNPRTGEAVEV IHFB_RHOSH 59 2 -
RMARNPRTGEEIKV Q8XU35 59 2 -
REGRNPKTNEKMEI DBH_ANASP 58 2 -
RTGRNPRTGTSVAV IHFB_RHOCA 59 2 -
RSGRNPRTGETVDV Q8YET3 66 2 -
RTGRNPRTGESVEV Q98GS0 59 2 -
REGRNPKTGAKMKI DBH_RICPR 67 2 -
RTGRNPRTGEAVDV Q9A2H5 59 2 -
RTGRNPATGATIEI Q9A5W6 59 2 -
RLGRNPKTGDSVNL IHFB_HAEIN 59 2 -
RSGRNPRTGDSVFV Q92SJ7 59 2 -
RPGRNPKTGEEIPI IHFA_PSEAE 61 2 -
RPGRNPKTGEEIPI IHFA_PSEPU 61 2 -
REARVPSTGKTIKV DBH_CAMJE 58 2 -
RTGRNPQTGKAIEI Q9HX76 60 2 -
RPGRNPKTGEEIPI IHFA_XANCA 60 2 -
RPGRNPKTGESVPV IHFA_PASMU 60 2 -
RIGRNPKTGKKIKL IHFB_BUCAP 59 2 -
RPGRNPKTGEEIPI IHFA_XYLFA 60 2 -
RIGRNPKTGKSVKL IHFB_BUCAI 59 2 -
RVARNPRTGETVKV DBH_MYCBO 58 2 -
RVARNPRTGETVKV DBH_MYCTU 58 2 -
RVARNPRTGETVKV DBH_MYCSM 58 2 -
RVARNPRTGETVKV DBH_MYCLE 58 2 -
RPGRNPKTGENVAV IHFA_PASHA 61 2 -
RPGRNPKTGEDIPI IHFA_SALTY 60 2 -
RPGRNPKTGEDIPI IHFA_VIBCH 60 2 -
RVGRNPKTGEKVEL IHFB_ERWCH 59 2 -
RTGRNPKTGDKVEL IHFB_ECOLI 59 2 -
RTGRNPKTGDKVEL Q8XFX6 59 2 -
RPGRNPRTGEIFLI IHFA_BUCAI 60 2 -
RPGRNPKTGEDIPI IHFA_ECOLI 60 2 -
RPGRNPKTGEDIPI Q8ZDX2 60 2 -
RPGRNPKTGEDIPI IHFA_YERPS 60 2 -
RPGRNPKTGEDIPI IHFA_SERMA 60 2 -
RPGRNPKTGEDIPI IHFA_ERWCH 60 2 -
RTGRNPSTGAAIEI Q93TM2 60 2 -
RLGRNPKTGESVLL IHFB_PASHA 59 2 -
RVGRNPKTGQSVSL IHFB_PSEPU 59 2 -
RVGRNPKTGDKVEL IHFB_SERMA 59 2 -
RVGRNPKTGDKVEL Q8ZGB1 59 2 -
RLGRNPKTGEQVKL IHFB_PASMU 59 2 -
RVGRNPKTGESVRL IHFB_PSEAE 59 2 -
RVGRNPKSGEKVLV Q8Y0Y3 59 2 -
RPGRNPKTGDVVPV IHFA_HAEIN 61 2 -
RVGRNPKTGDKVEL IHFB_VIBCH 59 2 -
RCGRNPKTGESVAL IHFB_XYLFA 59 2 -
RIGRNPKTGERVEV IHFB_NEIMA 64 2 -
RYARNPQTGERVRV DBH2_STRCO 57 2 -
RSGRNPLNGNAVFI IHFB_AGRTU 59 2 -
LNARNPQTGEYVKV DBH_BORAD 72 3 -
LNARNPQTGEYVKV DBH_BORJA 72 3 -
LNARNPQTGEYVKV DBH_BORGA 72 3 -
LNARNPQTGEYVKV DBH_BORBU 72 3 -
LNARNPQTGEYVKV DBH_BORAF 72 3 -
QNARNPQTGEYVNV DBH_BORPR 72 3 -
QNARNPQTGEYVNV DBH_BORTU 72 3 -

Motif 3 width=15
Element Seqn Id St Int Rpt
SKVPAFKAGKALKDA DBH_STRMU 75 2 -
SKVPAFKAGKALKDA DBH_STRDO 75 2 -
SKVPAFKAGKALKDA Q99U17 74 2 -
SKVPAFKAGKALKDA DBH_STRPY 75 2 -
SKVPAFKAGKALKDA DBH_STRGN 75 2 -
SKVPAFKAGKALKDA DBH_STRTR 75 2 -
SKVPAFKPGKALKDA DBH_BACST 74 2 -
SKVPAFKAGKALKDA Q97QT6 75 2 -
AKVPSFKAGKALKDA DBHB_VIBCH 74 2 -
RKVPAFRAGKALKDA DBHB_SERMA 74 2 -
SKVPAFKPGKALKDA DBH1_BACSU 74 2 -
TKTPAFKAGKQLKDA DBH2_BACHD 74 2 -
SKVPAFVAGKALKDA DBH_PASMU 74 2 -
ANVPAFVAGKALKDA DBHA_VIBCH 74 2 -
ANVPAFVSGKALKDA DBHA_ECOLI 74 2 -
ANVPAFVSGKALKDA DBHA_SERMA 74 2 -
ANVPAFVSGKALKDA DBHA_SALTY 74 2 -
TVVPAFKAGKALKDA DBH_LACLA 75 2 -
ANVPAFVSGKALKDA Q8ZAR0 74 2 -
AKVPSFRAGKALKDA DBHB_ECOLI 74 2 -
AKVPSFRAGKALKDA DBHB_SALTY 74 2 -
AKVPGFKAGKGLKDA Q93TM3 74 2 -
SKVPAFVSGKALKDA DBH_HAEIN 74 2 -
AKVPGFRAGKGLKDA Q8ZC68 74 2 -
TKNPAFKPGKQLKDA DBH1_BACHD 74 2 -
ANVPSFVAGKALKDA DBHA_AERHY 74 2 -
AKIPGFKAGKALKDA DBHB_PSEAE 74 2 -
ANVPAFVAGKALKDA DBHA_VIBPR 74 2 -
SKVPAFKPGKALKEA Q92A74 75 2 -
AKVPKFRPGKALKDA Q9R336 74 2 -
TKAPAFKPAKALKDA DBH2_BACSU 74 2 -
AKVAKFKPGKALKDA Q8XYP4 74 2 -
AKTPKFRAGKALKDA DBHB_NEIMA 74 2 -
AKKPGFKAGKALKEA DBHB_PSEFL 74 2 -
TKVPSFTSGKTLKNA DBH_BUCAI 74 2 -
SKVPAFKPGKALKEA O85384 67 2 -
SNNPSFKPGKALKDA DBH_XYLFA 74 2 -
RTVPKFSAGKGLKDA Q982V3 74 2 -
AKTVKFTAGKAFKDA DBHA_BURPS 74 2 -
TTVPVFKAGKEFKDK DBH_CLOPA 74 2 -
RNVPKFSAGKGLKDA Q8YHC5 76 2 -
TKVPAFSAGKMFKDK DBH_SYNY3 80 2 -
SIAPVFKPGKELKER Q8XHK4 74 2 -
SNTVAFKPGKALRDA DBHA_PSEAE 74 2 -
STVPVFKAGKEFKER Q97EA3 74 2 -
RNVPKFTAGKGLKDA DBH_RHIME 74 2 -
TQYPAFKPGKALKDK DBH_THETH 79 2 -
RNVPKFSAGKGLKDA DBH1_RHILE 74 2 -
RKVPKFKPGKALKEK DBH_THEMA 74 2 -
RKTPKFRSGKALKDA DBHC_NEIMA 74 2 -
TKTVKFTAGKGFKDA Q8XWF3 75 2 -
RNVPKFTPGKGLKDA DBH5_RHILE 74 2 -
KKVPFFKTGKLLRDR IHFB_RHOSH 75 2 -
AKTVKFKAGQKFKDA Q8XU35 75 2 -
TRVPAFSAGKLFREK DBH_ANASP 74 2 -
KHVPFFKTGKLLRDR IHFB_RHOCA 75 2 -
KWVPFFKTGKKLRDR Q8YET3 82 2 -
KWVPFFKTGKELRER Q98GS0 75 2 -
YNQPTFRAGRKLKEA DBH_RICPR 83 2 -
KHVPFFKSGKELRAR Q9A2H5 75 2 -
SKKVGFTPAKQLKDA Q9A5W6 75 2 -
KSVPYFKAGKELKAR IHFB_HAEIN 75 2 -
KWVPFFKTGKELRER Q92SJ7 75 2 -
RRVVTFRPGQKLKAR IHFA_PSEAE 77 2 -
RRVVTFRPGQKLKAR IHFA_PSEPU 77 2 -
TRVAKFKVGKNLKEA DBH_CAMJE 74 2 -
KRVAKFVPAKALTDA Q9HX76 76 2 -
RTVVTFRPGQKLKER IHFA_XANCA 76 2 -
RRVVAFKPGQKLRAR IHFA_PASMU 76 2 -
RYIPYFKPGKQLRDR IHFB_BUCAP 75 2 -
RTVVTFRSGQKLKER IHFA_XYLFA 76 2 -
KYVPYFKPGKKLRDR IHFB_BUCAI 75 2 -
TSVPAFRPGAQFKAV DBH_MYCBO 74 2 -
TSVPAFRPGAQFKAV DBH_MYCTU 74 2 -
TSVPAFRPGAQFKAV DBH_MYCSM 74 2 -
TSVPAFRPGAQFKAV DBH_MYCLE 74 2 -
RRVVVFKAGQKLRER IHFA_PASHA 77 2 -
RRVVTFRPGQKLKSR IHFA_SALTY 76 2 -
RRVVTFRPGQKLKAR IHFA_VIBCH 76 2 -
KYVPHFKPGKELRDR IHFB_ERWCH 75 2 -
KYVPHFKPGKELRDR IHFB_ECOLI 75 2 -
KYVPHFKPGKELRDR Q8XFX6 75 2 -
RRVVTFKAGQKLKNK IHFA_BUCAI 76 2 -
RRVVTFRPGQKLKSR IHFA_ECOLI 76 2 -
RRVVTFRPGQKLKSR Q8ZDX2 76 2 -
RRVVTFRPGQKLKSR IHFA_YERPS 76 2 -
RRVVTFRPGQKLKSR IHFA_SERMA 76 2 -
RRVVTFRPGQKLKSR IHFA_ERWCH 76 2 -
KKVVKFVPAKVLTDA Q93TM2 76 2 -
KYVPHFKAGKDLKER IHFB_PASHA 75 2 -
KFVPHFKPGKELRDR IHFB_PSEPU 75 2 -
KYVPHFKPGKELRDR IHFB_SERMA 75 2 -
KYVPHFKPGKELRDR Q8ZGB1 75 2 -
KSVPHFKAGKELRER IHFB_PASMU 75 2 -
KFVPHFKPGKELRDR IHFB_PSEAE 75 2 -
KRVPHFKAGKELRER Q8Y0Y3 75 2 -
RRVVTFKPGQKLRAR IHFA_HAEIN 77 2 -
KYVPHFKPGKELRER IHFB_VIBCH 75 2 -
KYVPHFKPGKELRER IHFB_XYLFA 75 2 -
KHVPHFKPGKELRER IHFB_NEIMA 80 2 -
TSVPRFRAGQGFKDL DBH2_STRCO 73 2 -
KWVPFFRAGKEIRDR IHFB_AGRTU 75 2 -
HHVAYFRPGKDLKER DBH_BORAD 88 2 -
HHVAYFRPGKDLKER DBH_BORJA 88 2 -
HHVAYFRPGKDLKER DBH_BORGA 88 2 -
HHVAYFRPGKDLKER DBH_BORBU 88 2 -
HHVAYFRPGKDLKER DBH_BORAF 88 2 -
HHVAYFRPGKDLKDG DBH_BORPR 88 2 -
HHVAYFRPGKDLKER DBH_BORTU 88 2 -