SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View



  selected as


PR01697

Identifier
PARVALBUMIN  [View Relations]  [View Alignment]  
Accession
PR01697
No. of Motifs
4
Creation Date
30-NOV-2001
Title
Parvalbumin signature
Database References

PDB; 1A75; 1B8R; 1BU3; 1CDP; 1PVA; 1RTP; 2PAS; 2PVB

PDB; 5CPV; 5PAL
SCOP; 1A75; 1B8R; 1BU3; 1CDP; 1PVA; 1RTP; 2PAS; 2PVB

SCOP; 5CPV; 5PAL
CATH; 1A75; 1B8R; 1BU3; 1CDP; 1PVA; 1RTP; 2PAS; 2PVB

CATH; 5CPV; 5PAL
Literature References
1. ELSAYED, S. AND BENNICH, H.
The primary structure of allergen M from Cod.
SCAND.J.IMMUNOL. 4 203-208 (1975).
 
2. SWAIN, A.L., KRETSINGER, R.H. AND AMMA, E.L.
Restrained least squares refinement of native (calcium) and calmodulin- 
J.BIOL.CHEM. 264 16620-16628 (1989).
 
3. LINDSTROM, D., VAN DO, T., HORDVIK, I., ENDRESEN, C. AND ELSAYED, S.
Cloning of two distinct cDNAs encoding parvalbumin, the major allergen of 
atlantic salmon (salmo salar).
SCAND.J.IMMUNOL. 44 335-344 (1996).

Documentation
substituted carp parvalbumin using X-ray crystallographic data at 1.6 
Angstroms resolution.
Fish allergies are common in Europe, particularly among male children and 
young adults. Children allergic to fish react variably to different species.
Cod is among the most common offenders, while salmon is the one best
tolerated. The allergy-eliciting protein has been isolated from the white
muscle albumin. It is a parvalbumin, designated Allergen M. Parvalbumins are
calcium (Ca)-binding proteins of low molecular weight. Like many other 
Ca-binding proteins, they belong to the EF-hand family characterised by
helix-loop-helix (HLH) binding motifs (two helices pack together at an angle
of ~90 degrees, separated by a loop region where calcium binds). In the 
parvalbumin HLH structural motif, calcium is coordinated through one 
carbonyl oxygen atom and the oxygen-containing side-chains of 5 amino acid
residues, or 4 residues and a water molecule [1-3].
 
Initially, parvalbumins were detected in relatively high amounts in lower
vertebrate white muscle, where they were thought to be important for fibre
relaxation. They were subsequently found, although in lesser amounts, in the
fast twitch skeletal muscles of higher vertebrates, as well as in a variety
of non-muscle tissues, including testis, endocrine glands, skin and specific
neurons. There are two distinct phylogenetic lineages: alpha and beta. Most
muscles contain parvalbumin of only alpha or beta origin. Cod parvalbumin 
belongs to the beta-lineage and shares significant similarity with 
parvalbumin of other fish species [1,3]. 
 
Allergen M contains 113 residues, is a homogenous acidic protein and belongs
to a group of muscle sarcoplasmic proteins. It carries the major allergenic
determinants associated with cod sensitivity, which is dependent directly on
the linear structure rather than on the molecular conformation. The 
allergenic activity of allergen M resides in particular epitopes found in
three loops: AB (~13-33), CD (~48-64) and EF (~80-103). It has an N-acetyl
terminal amino acid residue and includes 1 residue of glucose attached to 
the conserved N-terminal cysteine, and 1 residue each of tyrosine, 
tryptophan and arginine - the arginine is believed to play a key role in 
maintaining the tertiary structure. Mutation of the last conserved
coordinating residue of the Ca-binding loop (E101D-motif 4) has also been
shown to have a significant impact on the ability of the mutant to obtain
the sevenfold coordination preferred by Ca2+ [1].
 
PARVALBUMIN is a 4-element fingerprint that provides a signature for the  
parvalbumin family of proteins. The fingerprint was derived from an initial
alignment of 7 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length - motif 1 spans the region
between the AB and CD loops, which comprises the C-terminal 3/4 of helix 2,
helix 3 and the N-terminal 3/4 of helix 4; motif 2 spans the CD loop,
encompassing the first gamma-turn, the fourth-beta turn, helix 5 and the
N-terminal portion of helix 6; motif 3 encodes helix 7; and motif 4
encompasses the EF loop, including the N-terminal portion of the final 
helix. Three iterations on SPTR39_17f were required to reach convergence,
at which point a true set comprising 40 sequences was identified. 
Summary Information
40 codes involving  4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
440404040
30000
20000
1234
True Positives
ONCO_CAVPO    ONCO_HUMAN    ONCO_MOUSE    ONCO_RAT      
PRV1_SALSA PRV2_SALSA PRVA_AMPME PRVA_CYPCA
PRVA_ESOLU PRVA_FELCA PRVA_GERSP PRVA_HUMAN
PRVA_LATCH PRVA_MACFU PRVA_MOUSE PRVA_RABIT
PRVA_RAJCL PRVA_RANCA PRVA_RANES PRVA_RAT
PRVA_TRISE PRVB_AMPME PRVB_BOACO PRVB_CYPCA
PRVB_ESOLU PRVB_GADCA PRVB_GRAGE PRVB_LATCH
PRVB_LEUCE PRVB_MERBI PRVB_MERME PRVB_MERMR
PRVB_OPSTA PRVB_RANES PRVB_XENLA PRVM_CHICK
PRVT_CHICK PRVU_CHICK Q9I8V0 Q9UDU2
Sequence Titles
ONCO_CAVPO  ONCOMODULIN (OM) (PARVALBUMIN BETA) (CBP-15) - Cavia porcellus (Guinea pig). 
ONCO_HUMAN ONCOMODULIN (OM) (PARVALBUMIN BETA) - Homo sapiens (Human).
ONCO_MOUSE ONCOMODULIN (OM) (PARVALBUMIN BETA) - Mus musculus (Mouse).
ONCO_RAT ONCOMODULIN (OM) (PARVALBUMIN BETA) - Rattus norvegicus (Rat).
PRV1_SALSA PARVALBUMIN BETA 1 (MAJOR ALLERGEN SAL S 1) - Salmo salar (Atlantic salmon).
PRV2_SALSA PARVALBUMIN BETA 2 (MAJOR ALLERGEN SAL S 1) - Salmo salar (Atlantic salmon).
PRVA_AMPME PARVALBUMIN ALPHA - Amphiuma means (Salamander) (Two-toed amphiuma).
PRVA_CYPCA PARVALBUMIN ALPHA (A1) - Cyprinus carpio (Common carp).
PRVA_ESOLU PARVALBUMIN ALPHA - Esox lucius (Northern pike).
PRVA_FELCA PARVALBUMIN ALPHA - Felis silvestris catus (Cat).
PRVA_GERSP PARVALBUMIN ALPHA - Gerbillus sp. (Gerbil).
PRVA_HUMAN PARVALBUMIN ALPHA - Homo sapiens (Human).
PRVA_LATCH PARVALBUMIN ALPHA - Latimeria chalumnae (Latimeria) (Coelacanth).
PRVA_MACFU PARVALBUMIN ALPHA (PARVALBUMIN, MUSCLE) - Macaca fuscata fuscata (Japanese macaque).
PRVA_MOUSE PARVALBUMIN ALPHA - Mus musculus (Mouse).
PRVA_RABIT PARVALBUMIN ALPHA - Oryctolagus cuniculus (Rabbit).
PRVA_RAJCL PARVALBUMIN ALPHA - Raja clavata (Thornback ray).
PRVA_RANCA PARVALBUMIN ALPHA (PA 4.97) - Rana catesbeiana (Bull frog).
PRVA_RANES PARVALBUMIN ALPHA - Rana esculenta (Edible frog).
PRVA_RAT PARVALBUMIN ALPHA - Rattus norvegicus (Rat).
PRVA_TRISE PARVALBUMIN ALPHA - Triakis semifasciata (Leopard shark).
PRVB_AMPME PARVALBUMIN BETA - Amphiuma means (Salamander) (Two-toed amphiuma).
PRVB_BOACO PARVALBUMIN BETA - Boa constrictor (Boa).
PRVB_CYPCA PARVALBUMIN BETA - Cyprinus carpio (Common carp).
PRVB_ESOLU PARVALBUMIN BETA - Esox lucius (Northern pike).
PRVB_GADCA PARVALBUMIN BETA (ALLERGEN GAD C 1) (GAD C I) (ALLERGEN M) - Gadus callarias (Baltic cod).
PRVB_GRAGE PARVALBUMIN BETA - Graptemys geographica (Map turtle).
PRVB_LATCH PARVALBUMIN BETA - Latimeria chalumnae (Latimeria) (Coelacanth).
PRVB_LEUCE PARVALBUMIN BETA (V) - Leuciscus cephalus (Chub).
PRVB_MERBI PARVALBUMIN BETA - Merluccius bilinearis (Silver hake).
PRVB_MERME PARVALBUMIN BETA - Merluccius merluccius (European hake).
PRVB_MERMR PARVALBUMIN BETA - Merlangius merlangus (Whiting).
PRVB_OPSTA PARVALBUMIN BETA (PARVALBUMIN IIIF) - Opsanus tau (Oyster toadfish).
PRVB_RANES PARVALBUMIN BETA - Rana esculenta (Edible frog).
PRVB_XENLA PARVALBUMIN BETA - Xenopus laevis (African clawed frog).
PRVM_CHICK PARVALBUMIN, MUSCLE - Gallus gallus (Chicken).
PRVT_CHICK PARVALBUMIN, THYMIC (AVIAN THYMIC HORMONE) (ATH) (THYMUS-SPECIFIC ANTIGEN T1) - Gallus gallus (Chicken).
PRVU_CHICK PARVALBUMIN, THYMIC CPV3 (PARVALBUMIN 3) - Gallus gallus (Chicken).
Q9I8V0 PARVALBUMIN - Brachydanio rerio (Zebrafish) (Zebra danio).
Q9UDU2 WUGSC:H_DJ1163J12.1 PROTEIN - Homo sapiens (Human).
Scan History
SPTR39_17f 3  80   NSINGLE    
Initial Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
FFAKVGLTSKSADDVKKAF PRVB_CYPCA 29 29 -
FFAKVGLSAKTPDDIKKAF PRVA_CYPCA 29 29 -
FFAKVGLTAKSADDIKKAF PRVB_MERBI 29 29 -
FFAKCGLSGKSADDIKKAF PRVB_MERMR 29 29 -
FFAKVGLSAKTPDVIKKAF PRVB_OPSTA 29 29 -
FYAKVGLDAFSADELKKLF PRVB_GADCA 29 29 -
FFTKIGLKGKSAADIKKVF PRVB_MERME 29 29 -

Motif 2 width=17
Element Seqn Id St Int Rpt
DQDKSGFIEEDELKLFL PRVB_CYPCA 51 3 -
DQDKSGFIEEDELKLFL PRVA_CYPCA 51 3 -
DQDKSGFIEEDELKLFL PRVB_MERBI 51 3 -
DQDKSGFIEEDELKLFL PRVB_MERMR 51 3 -
DQDKSGFIEEDELKLFL PRVB_OPSTA 51 3 -
DEDKEGFIEEDELKLFL PRVB_GADCA 51 3 -
DQDKSDFVEEDELKLFL PRVB_MERME 51 3 -

Motif 3 width=14
Element Seqn Id St Int Rpt
RALTDGETKTFLKA PRVB_CYPCA 75 7 -
RALTDAETKAFLKA PRVA_CYPCA 75 7 -
RALTDAETKAFLKA PRVB_MERBI 75 7 -
RALTDAETKAFLKA PRVB_MERMR 75 7 -
RALTDKETETFLKA PRVB_OPSTA 75 7 -
RALTDAETKAFLKA PRVB_GADCA 75 7 -
RALTDAETATFLKA PRVB_MERME 75 7 -

Motif 4 width=14
Element Seqn Id St Int Rpt
GDSDGDGKIGVDEF PRVB_CYPCA 89 0 -
GDSDGDGKIGVDEF PRVA_CYPCA 89 0 -
GDSDGDGAIGVDEW PRVB_MERBI 89 0 -
GDSDGDGAIGVEEW PRVB_MERMR 89 0 -
GDSDGDGKIGIDEF PRVB_OPSTA 89 0 -
GDSDGDGKIGVDEF PRVB_GADCA 89 0 -
GDSDGDGKIGVEEF PRVB_MERME 89 0 -
Final Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
FFAKVGLSAKSPDDIKKAF Q9I8V0 30 30 -
FFAKVGLTSKSADDVKKAF PRVB_CYPCA 29 29 -
FFAKVGLSAKTPDDIKKAF PRVA_CYPCA 29 29 -
FFAQSGLSSKSADDVKNVF PRVB_XENLA 29 29 -
FFAKVGLASKSSDDVKKAF PRV2_SALSA 28 28 -
FFAKVGLASKSLDDVKKAF PRVB_ESOLU 28 28 -
FFAKVGLTAKSADDIKKAF PRVB_MERBI 29 29 -
FFSKVGLKGKSTDQVKKIF PRVB_GRAGE 29 29 -
FFQMVGLKKKSADDVKKVF PRVA_MACFU 29 29 -
FFQMVGLKKKSADDVKKVF PRVA_HUMAN 29 29 -
FFAKCGLSGKSADDIKKAF PRVB_MERMR 29 29 -
FFEMVGLKKKSPEDVKKVF PRVM_CHICK 29 29 -
FFQMVGLKKKTPDDVKKVF PRVA_GERSP 29 29 -
FFQMVGLKKKSADDVKKVF PRVA_RAT 29 29 -
FFAKVGMSAKSAGDVKKAF PRVB_LEUCE 27 27 -
FFAKVGLSAKTPDVIKKAF PRVB_OPSTA 29 29 -
FFSTVGLSSKTPDQIKKVF PRVT_CHICK 29 29 -
FFQMVGLKKKNPDEVKKVF PRVA_MOUSE 29 29 -
FFQMVGLKKKSTEDVKKVF PRVA_RABIT 29 29 -
FYAKVGLDAFSADELKKLF PRVB_GADCA 29 29 -
FFQKVGLAGKSAADAKKVF PRVB_RANES 29 29 -
FFALVGLKAMSANDVKKVF PRVA_ESOLU 28 28 -
FFTKIGLKGKSAADIKKVF PRVB_MERME 29 29 -
FFQMVGLKKKSPDDIKKVF PRVA_FELCA 29 29 -
FFTKCGLAGKPTDQVKKVF PRVB_AMPME 29 29 -
FFHTIGFASKSADDVKKAF PRV1_SALSA 30 30 -
FFNLVGLKGKPDDTLKEVF PRVA_LATCH 31 31 -
FFHLVGLKGKTDAQVKEVF PRVA_TRISE 29 29 -
FFAKSGLHSKSKDQLTKVF PRVB_BOACO 29 29 -
FFELCGLKSKSKEIMQKVF PRVA_RANES 29 29 -
FFEMCGLKSKGPDVMKQVF PRVA_RANCA 30 30 -
FFQKTGLAKKSNEELEAIF PRVB_LATCH 29 29 -
FFQISGMSKKSSSQLKEIF PRVU_CHICK 30 30 -
FVHLLGLNKRSPADVTKAF PRVA_AMPME 29 29 -
FFQTSGLSKMSASQVKDVF ONCO_CAVPO 29 29 -
FFQTSGLSKMSANQVKDVF ONCO_HUMAN 29 29 -
FFQTSGLSKMSANQVKDVF Q9UDU2 30 30 -
FFKASGLSKKSDAELAEIF PRVA_RAJCL 29 29 -
FFQTSGLSKMSASQLKDIF ONCO_MOUSE 29 29 -
FFQTSGLSKMSASQVKDIF ONCO_RAT 29 29 -

Motif 2 width=17
Element Seqn Id St Int Rpt
DQDKSGFIEEDELKLFL Q9I8V0 52 3 -
DQDKSGFIEEDELKLFL PRVB_CYPCA 51 3 -
DQDKSGFIEEDELKLFL PRVA_CYPCA 51 3 -
DQDRSGFIEEEELKLFL PRVB_XENLA 51 3 -
DQDKSGFIEEDELKLFL PRV2_SALSA 50 3 -
DQDKSGFIEEDELKLFL PRVB_ESOLU 50 3 -
DQDKSGFIEEDELKLFL PRVB_MERBI 51 3 -
DQDKSGFIEEDELQLFL PRVB_GRAGE 51 3 -
DKDKSGFIEEDELGFIL PRVA_MACFU 51 3 -
DKDKSGFIEEDELGFIL PRVA_HUMAN 51 3 -
DQDKSGFIEEDELKLFL PRVB_MERMR 51 3 -
DKDRSGFIEEEELKFVL PRVM_CHICK 51 3 -
DKDKSGFIEEDELGFIL PRVA_GERSP 51 3 -
DKDKSGFIEEDELGSIL PRVA_RAT 51 3 -
DEDKSGFIEEEELKLFL PRVB_LEUCE 49 3 -
DQDKSGFIEEDELKLFL PRVB_OPSTA 51 3 -
DQDKSGFIEEEELQLFL PRVT_CHICK 51 3 -
DKDKSGFIEEDELGSIL PRVA_MOUSE 51 3 -
DKDKSGFIEEEELGFIL PRVA_RABIT 51 3 -
DEDKEGFIEEDELKLFL PRVB_GADCA 51 3 -
DRDKSGFIEQDELGLFL PRVB_RANES 51 3 -
DADASGFIEEEELKFVL PRVA_ESOLU 50 3 -
DQDKSDFVEEDELKLFL PRVB_MERME 51 3 -
DKDKSGFIEEDELGFIL PRVA_FELCA 51 3 -
DQDKSGYIEEDELQLFL PRVB_AMPME 51 3 -
DQDASGFIEVEELKLFL PRV1_SALSA 52 3 -
DQDKSGYIEEEELKFVL PRVA_LATCH 53 3 -
DKDQSGFIEEEELKGVL PRVA_TRISE 51 3 -
DRDKSGYIEEDELKKFL PRVB_BOACO 51 3 -
DQDQSGFIEKEELCLIL PRVA_RANES 51 3 -
DQDRSGFIEEDELCLML PRVA_RANCA 52 3 -
DQDKSGFIEDEELELFL PRVB_LATCH 51 3 -
DNDQSGFIEEDELKYFL PRVU_CHICK 52 3 -
DKDRSGYIEEEELQLIL PRVA_AMPME 51 3 -
DNDQSGYLDEEELKFFL ONCO_CAVPO 51 3 -
DNDQSGYLDEEELKFFL ONCO_HUMAN 51 3 -
DNDQSGYLDEEELKFFL Q9UDU2 52 3 -
DGDQSGYIEVEELKNFL PRVA_RAJCL 51 3 -
DNDQSGYLDEDELKYFL ONCO_MOUSE 51 3 -
DNDQSGYLDGDELKYFL ONCO_RAT 51 3 -

Motif 3 width=14
Element Seqn Id St Int Rpt
RALTDAETKAFLSA Q9I8V0 76 7 -
RALTDGETKTFLKA PRVB_CYPCA 75 7 -
RALTDAETKAFLKA PRVA_CYPCA 75 7 -
RALTDAETKAFLAA PRVB_XENLA 75 7 -
RALTDAETKAFLAD PRV2_SALSA 74 7 -
RALTDAETKAFLAD PRVB_ESOLU 74 7 -
RALTDAETKAFLKA PRVB_MERBI 75 7 -
RALTAAETKAFMAA PRVB_GRAGE 75 7 -
RDLSAKETKTLMAA PRVA_MACFU 75 7 -
RDLSAKETKMLMAA PRVA_HUMAN 75 7 -
RALTDAETKAFLKA PRVB_MERMR 75 7 -
RDLSDKETKALLAA PRVM_CHICK 75 7 -
RDLSAKETKTLLAA PRVA_GERSP 75 7 -
RDLSAKETKTLMAA PRVA_RAT 75 7 -
RALTDAETKIFLKA PRVB_LEUCE 73 7 -
RALTDKETETFLKA PRVB_OPSTA 75 7 -
RVLTSAETKAFLAA PRVT_CHICK 75 7 -
RDLSAKETKTLLAA PRVA_MOUSE 75 7 -
RDLSVKETKTLMAA PRVA_RABIT 75 7 -
RALTDAETKAFLKA PRVB_GADCA 75 7 -
RVLSDAETSAFLKA PRVB_RANES 75 7 -
RDLTDAETKAFLKA PRVA_ESOLU 74 7 -
RALTDAETATFLKA PRVB_MERME 75 7 -
RDLSVKETKMLMAA PRVA_FELCA 75 7 -
RSLSNAETKAFLFA PRVB_AMPME 75 7 -
RELTDAETKAFLKA PRV1_SALSA 76 7 -
RELTANETKALLKA PRVA_LATCH 77 7 -
RDLNDTETKALLAA PRVA_TRISE 75 7 -
RDLTDKETAEFLKE PRVB_BOACO 75 7 -
RSLSDKETTALLAA PRVA_RANES 75 7 -
RSLSVKETTALLAA PRVA_RANCA 76 7 -
RTLTKTETETFLKA PRVB_LATCH 75 7 -
RVLTASETKTFLAA PRVU_CHICK 76 7 -
RELTDKETKDLLIK PRVA_AMPME 75 7 -
RELTESETKSLMAA ONCO_CAVPO 75 7 -
RELTESETKSLMAA ONCO_HUMAN 75 7 -
RELTESETKSLMAA Q9UDU2 76 7 -
RVLNDKETSNFLAA PRVA_RAJCL 75 7 -
RELTESETKSLMDA ONCO_MOUSE 75 7 -
RELTESETKSLMDA ONCO_RAT 75 7 -

Motif 4 width=14
Element Seqn Id St Int Rpt
GDSDGDGKIGVDEF Q9I8V0 90 0 -
GDSDGDGKIGVDEF PRVB_CYPCA 89 0 -
GDSDGDGKIGVDEF PRVA_CYPCA 89 0 -
GDSDGDGKIGVEEF PRVB_XENLA 89 0 -
GDKDGDGMIGVDEF PRV2_SALSA 88 0 -
GDKDGDGMIGVDEF PRVB_ESOLU 88 0 -
GDSDGDGAIGVDEW PRVB_MERBI 89 0 -
GDTDGDGKIGVDEF PRVB_GRAGE 89 0 -
GDKDGDGKIGVDEF PRVA_MACFU 89 0 -
GDKDGDGKIGVDEF PRVA_HUMAN 89 0 -
GDSDGDGAIGVEEW PRVB_MERMR 89 0 -
GDKDGDGKIGADEF PRVM_CHICK 89 0 -
GDKDGDGKIGVEEF PRVA_GERSP 89 0 -
GDKDGDGKIGVEEF PRVA_RAT 89 0 -
GDADGDGKIGIDEF PRVB_LEUCE 87 0 -
GDSDGDGKIGIDEF PRVB_OPSTA 89 0 -
GDTDGDGKIGVEEF PRVT_CHICK 89 0 -
GDKDGDGKIGVEEF PRVA_MOUSE 89 0 -
GDKDGDGKIGADEF PRVA_RABIT 89 0 -
GDSDGDGKIGVDEF PRVB_GADCA 89 0 -
GDSDGDGKIGVEEF PRVB_RANES 89 0 -
ADKDGDGKIGIDEF PRVA_ESOLU 88 0 -
GDSDGDGKIGVEEF PRVB_MERME 89 0 -
GDKDGDGKIDVDEF PRVA_FELCA 89 0 -
GDSDGDGKIGVDEF PRVB_AMPME 89 0 -
GDADGDGMIGIDEF PRV1_SALSA 90 0 -
GDQDGDDKIGVDEF PRVA_LATCH 91 0 -
GDSDHDGKIGADEF PRVA_TRISE 89 0 -
GDTDGDGKIGVEEF PRVB_BOACO 89 0 -
GDKDGDGKIGVDEF PRVA_RANES 89 0 -
GDKDGDGKIGMDEF PRVA_RANCA 90 0 -
GDSDGDGKIGVDEF PRVB_LATCH 89 0 -
ADHDGDGKIGAEEF PRVU_CHICK 90 0 -
GDKDGDGKIGVDEF PRVA_AMPME 89 0 -
ADNDGDGKIGADEF ONCO_CAVPO 89 0 -
ADNDGDGKIGAEEF ONCO_HUMAN 89 0 -
ADNDGDGKIGAEEF Q9UDU2 90 0 -
GDSDGDHKIGVDEF PRVA_RAJCL 89 0 -
ADNDGDGKIGADEF ONCO_MOUSE 89 0 -
ADNDGDGKIGADEF ONCO_RAT 89 0 -