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PR01689

Identifier
EP450IICYP3A  [View Relations]  [View Alignment]  
Accession
PR01689
No. of Motifs
6
Creation Date
13-MAR-2002
Title
CYP3A P450 family signature
Database References
PRINTS; PR00385 P450; PR00464 EP450II
Literature References
1. NOMENCLATURE COMMITTEE OF THE INTERNATIONAL UNION OF BIOCHEMISTRY
Nomenclature of electron-transfer proteins. Recommendations 1989.
EUR.J.BIOCHEMISTRY 200 599-611 (1991).
 
2. NEBERT, D.W. AND GONZALEZ, F.J.
P450 genes: structure, evolution, and regulation.
ANNU.REV.BIOCHEMISTRY 56 945-993 (1987).
 
3. NELSON, D.R., KAMATAKI, T., WAXMAN, D.J., GUENGERICH, F.P., ESTABROOK,
R.W., FEYEREISEN, R., GONZALEZ, F.J., COON, M.J., GUNSALUS, I.C., GOTOH, O.,
OKUDA, K. AND NEBERT, D.W.
The P450 superfamily: update on new sequences, gene mapping, accession
numbers, early trivial names of enzymes, and nomenclature.
DNA CELL BIOL. 12 1-51 (1993).
 
4. GOTOH, O.
Evolution and differentiation of P-450 genes.
IN BIOCHEMISTRY T., 2ND ED., ISHIMURA, Y. AND FUJII-KURIYAMA, Y., EDS., 
KODANSHA, TOKYO, 1993, PP.255-272.
 
5. NELSON, D.R.
Cytochrome P450 homepage.
http://drnelson.utmem.edu/CytochromeP450.html
 
6. NELSON, D.R.
Metazoan Cytochrome P450 evolution.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY PART C 121 15-22 (1998).
 
7. GRAHAM-LORENCE, S.E. AND PETERSON, J.A.
Structural alignments of P450s and extrapolations to the unknown.
METHODS ENZYMOL. 272 315-26 (1996).
 
8. LEWIS, D.F.V.
P450 substrate specificity and metabolism.
IN CYTOCHROMES P450: STRUCTURE, FUNCTION AND MECHANISM, TAYLOR AND FRANCIS
LTD., LONDON, 1996, PP.115-167.
 
9. LEWIS, D.F., EDDERSHAW, P.J., GOLDFARB, P.S. and TARBIT, M.H.
Molecular modelling of CYP3A4 from an alignment with CYP102: identification
of key interactions between putative active site residues and CYP3A-specific
chemicals.
XENOBIOTICA 26 1067-1086 (1996).

Documentation
P450 enzymes constitute a superfamily of haem-thiolate proteins [1], widely
distributed in bacteria, fungi, plants and animals. The enzymes are involved
in metabolism of a plethora of both exogenous and endogenous compounds [2].
Usually, they act as terminal oxidases in multi-component electron transfer
chains, called P450-containing monooxygenase systems.
 
Current P450 nomenclature, based on divergent evolution of the P450
superfamily, was proposed and developed by Nebert et al. [3]. On the basis
of sequence similarity, all P450s can be categorised into 2 main classes,
the so-called B- and E-classes: P450 proteins of prokaryotic 3-component
systems and fungal P450nor (CYP55) belong to the B-class; all other known
P450s from distinct systems are of the E-class [4]. E-class P450s may be
further divided into 5 subclasses (groups) according to protein sequence
similarities. 
 
Group II P450s are distributed widely in life, i.e., in eubacteria (family
CYP102), cyanobacteria (CYP110), fungi (CYP52, CYP53 and CYP56), insects
(CYP4 and CYP6) and mammals (CYP3, CYP4 and CYP5). Many group II P450s
catalyse hydroxylation of linear chains such as alkanes (CYP52), alcohols
and fatty acids (CYP4, CYP5, CYP102); Aspergillus niger CYP53 carries out
para-hydroxylation of benzoate; yeast CYP56 is possibly involved in
oxidation of tyrosine residues; insect CYP6 metabolises a wide range of
toxic compounds; and members of the CYP3 family are omnivorous [4]. The
existence of two prokaryotic P450s in group II strongly suggests that the
divergence of the P450 superfamily into B- and E-classes, and further
divergence into stable P450 groups within the E-class, must be very ancient
and had occured before the appearance of eukaryotes [4].
 
The 3D structure of the P450 domain of P450BM-3 (CYP102) has been determined
[7] and is used as a model for microsomal P450s. The P450 molecule is an
alpha/beta protein, shaped like a triangular prism: the overall structure
can be roughly divided into alpha-rich ('right side') and beta-rich ('left
side') domains. However, this division appears to be artificial since the 
alpha- and beta-rich domains comprise discontinuous assemblies of secondary
structure elements, and do not constitute independent folding units.
 
Due to the rapid increase in numbers of P450s, Nelson introduced the concept
of a higher order classification of P450 families into clans [6] based on
sequence similarity. This is similar to the previous grouping into B- and
E-classes; both classifications are still used. According to Nelson's
system, clans 3 and 4 correspond to the E-class group II proteins [6]. Clan
3 contains CYP3, 5, 6, 9 and 30; it might be extended to include CYP25 and
CYP13, both of which are from C.elegans.
 
Enzymes of the CYP3 family constitute major mammalian, especially human,
forms involved in the metabolism of foreign compounds [8]. There is
considerable structural variety in the known substrates of CYP3A enzymes and
it is difficult to categorise such diverse substrate specificity. Although a
number of 3A substrates are also metabolised by other P450s, such as 2D6 and
2C isozymes, the site of metabolism is often different and N-dealkylation is
a common feature of 3A mediated metabolism. One means of rationalising the
apparent lack of similarity in 3A substrates can be achieved by molecular
modelling of the relevant enzymes. It appears that a highly conserved
asparagine residue may be strategically placed in the 3A binding site such
that hydrogen-bonding interactions with known substrates enable orientation
for oxygenation in the relevant positions [9]. In general, the CYP3A
subfamily mediates detoxifying metabolism of exogenous substrates, but a
number of activating pathways, such as detoxifying carcinogens by additional
metabolism in alternative, non-activating positions, have been demonstrated
[8].
 
EP450IICYP3A is a 6-element fingerprint that provides a signature for the
CYP3A P450 family. The fingerprint was derived from an initial alignment of
21 sequences: the motifs were drawn from conserved regions spanning the 
N-terminal half of the alignment, focusing on those sections that
characterise the CYP3A proteins but distinguish them from the rest of the
P450 superfamily - using the model of Lewis et al. [9], motif 1 spans the
N-terminal membrane anchor domain; motif 2 spans beta-strands 1-5 and part
of the B/B' helix, and represents the N-terminus of the first substrate
recognition site (SRS1); motif 3 encodes the E helix; motif 4 lies between
the E and F helices; motif 5 spans the F-G loop between the F and G helices;
and motif 6 encodes the well-conserved H helix [7]. Two iterations on 
SPTR40_18f were required to reach convergence, at which point a true set
comprising 37 sequences was identified. Two partial matches were also found:
Q9PU44, a cytochrome P-450 encoding the CYP3A37 gene, matches motifs 1-4 
and 6; and Q9HB52 is human CYP3A43, which lacks motif 5 and 6.
Summary Information
  37 codes involving  6 elements
1 codes involving 5 elements
1 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
6373737373737
5111101
4111100
3000000
2000000
123456
True Positives
CP31_RAT      CP32_RAT      CP33_HUMAN    CP34_HUMAN    
CP35_HUMAN CP36_RABIT CP37_HUMAN CP38_MACFA
CP39_RAT CP3A_MESAU CP3B_MOUSE CP3C_CANFA
CP3D_MOUSE CP3E_CAVPO CP3F_CAVPO CP3G_MOUSE
CP3H_CAVPO CP3I_RAT CP3L_CALJA CP3O_SHEEP
CP3P_MOUSE CP3R_ONCMY CP3S_BOVIN CP3T_PIG
CP3V_MESAU O97689 Q06884 Q98T91
Q9DE99 Q9EQW4 Q9H241 Q9HB53
Q9HB54 Q9HB55 Q9JMA7 Q9PVE8
Q9QXK4
True Positive Partials
Codes involving 5 elements
Q9PU44
Codes involving 4 elements
Q9HB52
Sequence Titles
CP31_RAT    Cytochrome P450 3A1 (EC 1.14.14.1) (CYPIIIA1) (P450-PCN1) - Rattus norvegicus (Rat). 
CP32_RAT Cytochrome P450 3A2 (EC 1.14.14.1) (CYPIIIA2) (P450-PCN2) (P450/6- beta-A) (Testosterone 6-beta-hydroxylase) - Rattus norvegicus (Rat).
CP33_HUMAN Cytochrome P450 3A3 (EC 1.14.14.1) (CYPIIIA3) (HLp) - Homo sapiens (Human).
CP34_HUMAN Cytochrome P450 3A4 (EC 1.14.14.1) (CYPIIIA4) (Nifedipine oxidase) (NF-25) (P450-PCN1) - Homo sapiens (Human).
CP35_HUMAN Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (P450-PCN3) - Homo sapiens (Human).
CP36_RABIT Cytochrome P450 3A6 (EC 1.14.14.1) (CYPIIIA6) (P450-3C) - Oryctolagus cuniculus (Rabbit).
CP37_HUMAN Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (P450-HFLA) - Homo sapiens (Human).
CP38_MACFA Cytochrome P450 3A8 (EC 1.14.14.1) (CYPIIIA8) (P450-MKNF2) (P-450- MK2) - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
CP39_RAT Cytochrome P450 3A9 (EC 1.14.14.1) (CYPIIIA9) (P450-OLF3) (Olfactive) (3AH15) - Rattus norvegicus (Rat).
CP3A_MESAU Cytochrome P450 3A10 (EC 1.14.14.1) (CYPIIIA10) (6 beta-hydroxylase) - Mesocricetus auratus (Golden hamster).
CP3B_MOUSE Cytochrome P450 3A11 (EC 1.14.14.1) (CYPIIIA11) (P-450IIIAM1) (P- 450UT) - Mus musculus (Mouse).
CP3C_CANFA Cytochrome P450 3A12 (EC 1.14.14.1) (CYPIIIA12) (P450-PBD-1) - Canis familiaris (Dog).
CP3D_MOUSE Cytochrome P450 3A13 (EC 1.14.14.1) (CYPIIIA13) - Mus musculus (Mouse).
CP3E_CAVPO Cytochrome P450 3A14 (EC 1.14.14.1) (CYPIIIA14) - Cavia porcellus (Guinea pig).
CP3F_CAVPO Cytochrome P450 3A15 (EC 1.14.14.1) (CYPIIIA15) - Cavia porcellus (Guinea pig).
CP3G_MOUSE Cytochrome P450 3A16 (EC 1.14.14.1) (CYPIIIA16) - Mus musculus (Mouse).
CP3H_CAVPO Cytochrome P450 3A17 (EC 1.14.14.1) (CYPIIIA17) - Cavia porcellus (Guinea pig).
CP3I_RAT Cytochrome P450 3A18 (EC 1.14.14.1) (CYPIIIA18) (P450(6)beta-2) - Rattus norvegicus (Rat).
CP3L_CALJA Cytochrome P450 3A21 (EC 1.14.14.1) (CYPIIIA21) (P450 CM3A-10) - Callithrix jacchus (Common marmoset).
CP3O_SHEEP Cytochrome P450 3A24 (EC 1.14.14.1) (CYPIIIA24) - Ovis aries (Sheep).
CP3P_MOUSE Cytochrome P450 3A25 (EC 1.14.14.1) (CYPIIIA25) - Mus musculus (Mouse).
CP3R_ONCMY Cytochrome P450 3A27 (EC 1.14.14.1) (CYPIIIA27) - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
CP3S_BOVIN Cytochrome P450 3A28 (EC 1.14.14.1) (CYPIIIA28) - Bos taurus (Bovine).
CP3T_PIG Cytochrome P450 3A29 (EC 1.14.14.1) (CYPIIIA29) - Sus scrofa (Pig).
CP3V_MESAU Cytochrome P450 3A31 (EC 1.14.14.1) (CYPIIIA31) (P450 SH3A-1) - Mesocricetus auratus (Golden hamster).
O97689 CYTOCHROME P450 - Sus scrofa (Pig).
Q06884 CYTOCHROME P450 IIIA (EC 1.14.14.1) (STEROID INDUCIBLE) - Rattus norvegicus (Rat).
Q98T91 CYTOCHROM P450 3A40 - Oryzias latipes (Medaka fish).
Q9DE99 CYTOCHROME P450 3A - Oryzias latipes (Medaka fish).
Q9EQW4 CYTOCHROME P450, CYP3A - Mus musculus (Mouse).
Q9H241 CYTOCHROME P450 3A7 - Homo sapiens (Human).
Q9HB53 CYTOCHROME P450 SUBFAMILY IIIA POLYPEPTIDE 43 - Homo sapiens (Human).
Q9HB54 CYTOCHROME P450 SUBFAMILY IIIA POLYPEPTIDE 43 - Homo sapiens (Human).
Q9HB55 CYTOCHROME P450 SUBFAMILY IIIA POLYPEPTIDE 43 (CYTOCHROME P450 CYP3A43) - Homo sapiens (Human).
Q9JMA7 CYTOCHROME P450 - Mus musculus (Mouse).
Q9PVE8 CYTOCHROME P450 3A30 - Fundulus heteroclitus (Killifish) (Mummichog).
Q9QXK4 CYTOCHROME P450 3A25 - Mus musculus (Mouse).

Q9PU44 CYTOCHROME P450 - Gallus gallus (Chicken).

Q9HB52 CYTOCHROME P450 SUBFAMILY IIIA POLYPEPTIDE 43 - Homo sapiens (Human).
Scan History
SPTR40_18f 2  175  NSINGLE    
Initial Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
ETWLLLAVSLVLLY CP3L_CALJA 10 10 -
ETWLLLAVSLVLLY CP33_HUMAN 9 9 -
ETWLLLAVSLVLLY CP35_HUMAN 10 10 -
ETWMLLATSLVLLY CP3D_MOUSE 10 10 -
ETWVLLAVVLVLLY CP31_RAT 10 10 -
ETWVLLAISLVLLY CP3V_MESAU 10 10 -
ETWVLLAASLVLLY CP36_RABIT 8 8 -
ETWVLLATSLMLFY CP3I_RAT 10 10 -
ETWVLLAVILVLLY CP32_RAT 10 10 -
ETWVLLVTSLVLFY CP3P_MOUSE 10 10 -
ETWLLLAISLVLLY CP3C_CANFA 10 10 -
ETWLLLAVTLVLLY CP38_MACFA 10 10 -
ETWVLLATSLVLLY CP3T_PIG 10 10 -
ETWLLLVISLVLLY CP39_RAT 10 10 -
ETWLLLAVSLILLY CP37_HUMAN 10 10 -
ETWVLLALSLVLLY CP3E_CAVPO 10 10 -
ETWVLLALSLVLLY CP3H_CAVPO 10 10 -
ETWVLLAISLVLIY CP3A_MESAU 10 10 -
ETWVLLALSLVLLY CP3F_CAVPO 10 10 -
DTLVLLAIILVLLY CP3G_MOUSE 10 10 -
ETWTLLALLITLIV CP3R_ONCMY 11 11 -

Motif 2 width=13
Element Seqn Id St Int Rpt
VLVKECYSVFTNR CP3L_CALJA 93 69 -
VLVKECYSVFTNR CP33_HUMAN 92 69 -
VLVKECYSVFTNR CP35_HUMAN 93 69 -
VLVKECYSTFTNR CP3D_MOUSE 93 69 -
VLVKECFSVFTNR CP31_RAT 93 69 -
VLVKECYSIFTNR CP3V_MESAU 93 69 -
VLVKECYSVFTNR CP36_RABIT 91 69 -
VLVKECYSVFTNR CP3I_RAT 93 69 -
VLVKECFSVFTNR CP32_RAT 93 69 -
VLVKECYSVFTNR CP3P_MOUSE 93 69 -
VLVKECYSVFTNR CP3C_CANFA 93 69 -
VLVKECYSVFTNR CP38_MACFA 93 69 -
VLVKECYSVFTNR CP3T_PIG 93 69 -
VLVKECYSTFTNR CP39_RAT 93 69 -
VLVKECYSVFTNR CP37_HUMAN 93 69 -
VLVKECYSVFTNR CP3E_CAVPO 93 69 -
VLVKECYSVFTNR CP3H_CAVPO 93 69 -
VLVKECYSNFTNR CP3A_MESAU 93 69 -
VLVKECYSVFTNR CP3F_CAVPO 93 69 -
VLVKECFSVFTNR CP3G_MOUSE 93 69 -
VLIKECYNIFTNR CP3R_ONCMY 94 69 -

Motif 3 width=12
Element Seqn Id St Int Rpt
KDIFGAYSMDVI CP3L_CALJA 173 67 -
KDVFGAYSMDVI CP33_HUMAN 172 67 -
KDIFGAYSMDVI CP35_HUMAN 173 67 -
KDIFGAYSMDVI CP3D_MOUSE 173 67 -
KKVFGAYSMDVI CP31_RAT 173 67 -
KEVFGAYSMDVI CP3V_MESAU 173 67 -
KEIFGAYSMDVI CP36_RABIT 171 67 -
KDIFGAYSMDVI CP3I_RAT 173 67 -
KKVFGAYSMDVI CP32_RAT 173 67 -
KDIFGAYSMDVI CP3P_MOUSE 173 67 -
KDVFGAYSMDVI CP3C_CANFA 173 67 -
KDVFGAYSMDVI CP38_MACFA 173 67 -
KDIFGAYSMDVI CP3T_PIG 173 67 -
KDIFGAYSMDVI CP39_RAT 173 67 -
KHVFGAYSMDVI CP37_HUMAN 173 67 -
KEIFGAYSMDII CP3E_CAVPO 173 67 -
KEIFGAYSMDII CP3H_CAVPO 173 67 -
KEILGAYSMDVI CP3A_MESAU 173 67 -
KEIFGAYGMDII CP3F_CAVPO 173 67 -
KDVLGAYSMDVI CP3G_MOUSE 173 67 -
KEFFGPYSMDVV CP3R_ONCMY 174 67 -

Motif 4 width=11
Element Seqn Id St Int Rpt
FGVNIDSLNNP CP3L_CALJA 189 4 -
FGVNVDSLNNP CP33_HUMAN 188 4 -
FGVNIDSLNNP CP35_HUMAN 189 4 -
FGVNIDSLNNP CP3D_MOUSE 189 4 -
FGVNVDSLNNP CP31_RAT 189 4 -
FGVSVDSLNNP CP3V_MESAU 189 4 -
FGVNIDSLRNP CP36_RABIT 187 4 -
FGVNVDSLNNP CP3I_RAT 189 4 -
FGVNVDSLNNP CP32_RAT 189 4 -
FGVNVDSLNNP CP3P_MOUSE 189 4 -
FGVNIDSLNHP CP3C_CANFA 189 4 -
FGVNIDSLNNP CP38_MACFA 189 4 -
FGVNIDSLNNP CP3T_PIG 189 4 -
FGVNVDSLNNP CP39_RAT 189 4 -
FGVSIDSLNNP CP37_HUMAN 189 4 -
FGVNVDSLNNP CP3E_CAVPO 189 4 -
FGVNVDSLNNP CP3H_CAVPO 189 4 -
FGVNVDSLNNP CP3A_MESAU 189 4 -
FGVNVDSLNNP CP3F_CAVPO 189 4 -
FGVNIDSLNNP CP3G_MOUSE 189 4 -
FSVDIDSLNNP CP3R_ONCMY 190 4 -

Motif 5 width=12
Element Seqn Id St Int Rpt
PFFLSITIFPFL CP3L_CALJA 218 18 -
PFFLSITVFPFL CP33_HUMAN 217 18 -
PLFLSIILFPFL CP35_HUMAN 218 18 -
PLFLSVTLFPFL CP3D_MOUSE 218 18 -
PLFLSVVLFPFL CP31_RAT 218 18 -
PLFLSVVLFPFL CP3V_MESAU 217 17 -
PLLLSITLFPFL CP36_RABIT 216 18 -
PFLLSVVLFPFL CP3I_RAT 218 18 -
PLFLSVVLFPFL CP32_RAT 218 18 -
PFLLSIILFPFL CP3P_MOUSE 218 18 -
PFFFSILLFPFL CP3C_CANFA 218 18 -
PFFLSITIFPFI CP38_MACFA 218 18 -
PFLLSLIFFPFL CP3T_PIG 218 18 -
PLFLSVTLFPFL CP39_RAT 218 18 -
PFVLSIKVFPFL CP37_HUMAN 218 18 -
PFLLSIVMFPFL CP3E_CAVPO 218 18 -
PFLLSVVIFPFL CP3H_CAVPO 218 18 -
PFILSIILFPFL CP3A_MESAU 218 18 -
PFLLSTVMFPFL CP3F_CAVPO 218 18 -
PLSLSVALFPFL CP3G_MOUSE 218 18 -
PLFLLVALFPFT CP3R_ONCMY 219 18 -

Motif 6 width=11
Element Seqn Id St Int Rpt
KHRVDFLQLMI CP3L_CALJA 266 36 -
KHRVDFLQLMI CP33_HUMAN 265 36 -
KHRLDFLQLMI CP35_HUMAN 266 36 -
KQRVDFLQLMI CP3D_MOUSE 266 36 -
KHRVDFLQLMM CP31_RAT 266 36 -
KHRVDFLQLMM CP3V_MESAU 265 36 -
KRRVDFLQLMI CP36_RABIT 264 36 -
KNRVDFLQLMM CP3I_RAT 266 36 -
KHRVDFLQLML CP32_RAT 266 36 -
KNRVDFLQLMM CP3P_MOUSE 266 36 -
KHRVDFLQLMI CP3C_CANFA 266 36 -
KHRVDFLQLMI CP38_MACFA 266 36 -
KRRVDLLQLMI CP3T_PIG 266 36 -
KQRMDFLQLMI CP39_RAT 266 36 -
KHRVDFLQLMI CP37_HUMAN 266 36 -
KQRVDFLQMML CP3E_CAVPO 266 36 -
KQRVNFLQMML CP3H_CAVPO 266 36 -
KTRMDFFQLMM CP3A_MESAU 266 36 -
KQRVNFLQMML CP3F_CAVPO 266 36 -
KHRVDFIYLMM CP3G_MOUSE 266 36 -
TNRVDFLQLMI CP3R_ONCMY 267 36 -
Final Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
ETWLLLAVSLVLLY CP34_HUMAN 9 9 -
ETWLLLAVSLVLLY CP3L_CALJA 10 10 -
ETWLLLAVSLVLLY CP33_HUMAN 9 9 -
ETWLLLAVSLVLLY CP35_HUMAN 10 10 -
ETWVLLAISLVLLY CP3O_SHEEP 10 10 -
ETWMLLATSLVLLY CP3D_MOUSE 10 10 -
ETWVLLAVVLVLLY Q06884 10 10 -
ETWVLLAVVLVLLY CP31_RAT 10 10 -
ETWVLLAISLVLLY CP3V_MESAU 10 10 -
ETWVLLAASLVLLY CP36_RABIT 8 8 -
ETWVLLATSLMLFY CP3I_RAT 10 10 -
ETWVLLAVILVLLY CP32_RAT 10 10 -
ETWVLLVTSLVLFY CP3P_MOUSE 10 10 -
ETWVLLVTSLVLFY Q9QXK4 10 10 -
ETWLLLAISLVLLY CP3C_CANFA 10 10 -
ETWVLLAISLVLLY CP3B_MOUSE 10 10 -
ETWLLLAVTLVLLY CP38_MACFA 10 10 -
ETWVLLATSLVLLY CP3T_PIG 10 10 -
ETWVLLATSLVLLY O97689 10 10 -
ETWLLLVISLVLLY CP39_RAT 10 10 -
ETWVLLATSLVLLY CP3S_BOVIN 10 10 -
ETWLLLAVSLILLY CP37_HUMAN 10 10 -
ETWLLLAVSLILLY Q9H241 10 10 -
ETWVLLALSLVLLY CP3E_CAVPO 10 10 -
ETWVLLALSLVLLY CP3H_CAVPO 10 10 -
DTWVLLAIILVLLY Q9JMA7 10 10 -
ETWVLLAISLVLIY CP3A_MESAU 10 10 -
ETWVLVATSLVLLY Q9HB53 10 10 -
ETWVLVATSLVLLY Q9HB54 10 10 -
ETWVLVATSLVLLY Q9HB55 10 10 -
ETWVLLALSLVLLY CP3F_CAVPO 10 10 -
DTLVLLAIILVLLY CP3G_MOUSE 10 10 -
DTLVLLAIILVLLY Q9EQW4 10 10 -
ETWTLLVAFITLLL Q9DE99 10 10 -
ETWTLLVAFVTLLL Q9PVE8 9 9 -
ETWTLLVAFITLLL Q98T91 10 10 -
ETWTLLALLITLIV CP3R_ONCMY 11 11 -

Motif 2 width=13
Element Seqn Id St Int Rpt
VLVKECYSVFTNR CP34_HUMAN 92 69 -
VLVKECYSVFTNR CP3L_CALJA 93 69 -
VLVKECYSVFTNR CP33_HUMAN 92 69 -
VLVKECYSVFTNR CP35_HUMAN 93 69 -
VLVKECYSVFTNR CP3O_SHEEP 93 69 -
VLVKECYSTFTNR CP3D_MOUSE 93 69 -
VLVKECFSVFTNR Q06884 93 69 -
VLVKECFSVFTNR CP31_RAT 93 69 -
VLVKECYSIFTNR CP3V_MESAU 93 69 -
VLVKECYSVFTNR CP36_RABIT 91 69 -
VLVKECYSVFTNR CP3I_RAT 93 69 -
VLVKECFSVFTNR CP32_RAT 93 69 -
VLVKECYSVFTNR CP3P_MOUSE 93 69 -
VLVKECYSVFTNR Q9QXK4 93 69 -
VLVKECYSVFTNR CP3C_CANFA 93 69 -
VLVKECFSVFTNR CP3B_MOUSE 93 69 -
VLVKECYSVFTNR CP38_MACFA 93 69 -
VLVKECYSVFTNR CP3T_PIG 93 69 -
VLVKECYSVFTNR O97689 93 69 -
VLVKECYSTFTNR CP39_RAT 93 69 -
VLVKECYSVFTNR CP3S_BOVIN 93 69 -
VLVKECYSVFTNR CP37_HUMAN 93 69 -
VLVKECYSVFTNR Q9H241 93 69 -
VLVKECYSVFTNR CP3E_CAVPO 93 69 -
VLVKECYSVFTNR CP3H_CAVPO 93 69 -
VLVKECFSVFTNR Q9JMA7 93 69 -
VLVKECYSNFTNR CP3A_MESAU 93 69 -
VLVKECYSVFTNQ Q9HB53 93 69 -
VLVKECYSVFTNQ Q9HB54 93 69 -
VLVKECYSVFTNQ Q9HB55 93 69 -
VLVKECYSVFTNR CP3F_CAVPO 93 69 -
VLVKECFSVFTNR CP3G_MOUSE 93 69 -
VLVKDCLSVFTNR Q9EQW4 93 69 -
VLVKECYSLFTNR Q9DE99 93 69 -
VLVKECLSFFTNR Q9PVE8 92 69 -
VLVKECYSLFTNR Q98T91 93 69 -
VLIKECYNIFTNR CP3R_ONCMY 94 69 -

Motif 3 width=12
Element Seqn Id St Int Rpt
KDVFGAYSMDVI CP34_HUMAN 172 67 -
KDIFGAYSMDVI CP3L_CALJA 173 67 -
KDVFGAYSMDVI CP33_HUMAN 172 67 -
KDIFGAYSMDVI CP35_HUMAN 173 67 -
KDIFGAYSMDVI CP3O_SHEEP 173 67 -
KDIFGAYSMDVI CP3D_MOUSE 173 67 -
KEVFGAYSMDVI Q06884 171 65 -
KKVFGAYSMDVI CP31_RAT 173 67 -
KEVFGAYSMDVI CP3V_MESAU 173 67 -
KEIFGAYSMDVI CP36_RABIT 171 67 -
KDIFGAYSMDVI CP3I_RAT 173 67 -
KKVFGAYSMDVI CP32_RAT 173 67 -
KDIFGAYSMDVI CP3P_MOUSE 173 67 -
KDIFGAYSMDVI Q9QXK4 173 67 -
KDVFGAYSMDVI CP3C_CANFA 173 67 -
KDVLGAYSMDVI CP3B_MOUSE 173 67 -
KDVFGAYSMDVI CP38_MACFA 173 67 -
KDIFGAYSMDVI CP3T_PIG 173 67 -
KDIFGAYSMDVI O97689 173 67 -
KDIFGAYSMDVI CP39_RAT 173 67 -
KDMFGAYSMDVI CP3S_BOVIN 173 67 -
KHVFGAYSMDVI CP37_HUMAN 173 67 -
KHVFGAYSMDVI Q9H241 173 67 -
KEIFGAYSMDII CP3E_CAVPO 173 67 -
KEIFGAYSMDII CP3H_CAVPO 173 67 -
KDVLGAYSIDVI Q9JMA7 173 67 -
KEILGAYSMDVI CP3A_MESAU 173 67 -
KDFFGAYTMDVI Q9HB53 173 67 -
KDFFGAYTMDVI Q9HB54 173 67 -
KDFFGAYTMDVI Q9HB55 173 67 -
KEIFGAYGMDII CP3F_CAVPO 173 67 -
KDVLGAYSMDVI CP3G_MOUSE 173 67 -
KDVLGAYSMDVI Q9EQW4 173 67 -
KDHFGPYSMDVV Q9DE99 173 67 -
KEFFGSYSMDVV Q9PVE8 172 67 -
KEYFGPYSMDVV Q98T91 173 67 -
KEFFGPYSMDVV CP3R_ONCMY 174 67 -

Motif 4 width=11
Element Seqn Id St Int Rpt
FGVNIDSLNNP CP34_HUMAN 188 4 -
FGVNIDSLNNP CP3L_CALJA 189 4 -
FGVNVDSLNNP CP33_HUMAN 188 4 -
FGVNIDSLNNP CP35_HUMAN 189 4 -
FGVNIDSLGNP CP3O_SHEEP 189 4 -
FGVNIDSLNNP CP3D_MOUSE 189 4 -
FGVNVDSLNNP Q06884 187 4 -
FGVNVDSLNNP CP31_RAT 189 4 -
FGVSVDSLNNP CP3V_MESAU 189 4 -
FGVNIDSLRNP CP36_RABIT 187 4 -
FGVNVDSLNNP CP3I_RAT 189 4 -
FGVNVDSLNNP CP32_RAT 189 4 -
FGVNVDSLNNP CP3P_MOUSE 189 4 -
FGVNVDSLNNP Q9QXK4 189 4 -
FGVNIDSLNHP CP3C_CANFA 189 4 -
FGVNVDSLNNP CP3B_MOUSE 189 4 -
FGVNIDSLNNP CP38_MACFA 189 4 -
FGVNIDSLNNP CP3T_PIG 189 4 -
FGVNTDFLNNP O97689 189 4 -
FGVNVDSLNNP CP39_RAT 189 4 -
FGVNIDSLNNP CP3S_BOVIN 189 4 -
FGVSIDSLNNP CP37_HUMAN 189 4 -
FGVSIDSLNNP Q9H241 189 4 -
FGVNVDSLNNP CP3E_CAVPO 189 4 -
FGVNVDSLNNP CP3H_CAVPO 189 4 -
FGVNVDSLNNP Q9JMA7 189 4 -
FGVNVDSLNNP CP3A_MESAU 189 4 -
FGVNLDSLNNP Q9HB53 189 4 -
FGVNLDSLNNP Q9HB54 189 4 -
FGVNLDSLNNP Q9HB55 189 4 -
FGVNVDSLNNP CP3F_CAVPO 189 4 -
FGVNIDSLNNP CP3G_MOUSE 189 4 -
FGVNVDSLNNP Q9EQW4 189 4 -
FSVDIDSLNNP Q9DE99 189 4 -
FSVDIDSLNNP Q9PVE8 188 4 -
FSVDIDSLNNP Q98T91 189 4 -
FSVDIDSLNNP CP3R_ONCMY 190 4 -

Motif 5 width=12
Element Seqn Id St Int Rpt
PFFLSITVFPFL CP34_HUMAN 217 18 -
PFFLSITIFPFL CP3L_CALJA 218 18 -
PFFLSITVFPFL CP33_HUMAN 217 18 -
PLFLSIILFPFL CP35_HUMAN 218 18 -
PFLLSVVLFPFL CP3O_SHEEP 218 18 -
PLFLSVTLFPFL CP3D_MOUSE 218 18 -
PLFLSVVLFPFL Q06884 216 18 -
PLFLSVVLFPFL CP31_RAT 218 18 -
PLFLSVVLFPFL CP3V_MESAU 217 17 -
PLLLSITLFPFL CP36_RABIT 216 18 -
PFLLSVVLFPFL CP3I_RAT 218 18 -
PLFLSVVLFPFL CP32_RAT 218 18 -
PFLLSIILFPFL CP3P_MOUSE 218 18 -
PFLLSIILFPFL Q9QXK4 218 18 -
PFFFSILLFPFL CP3C_CANFA 218 18 -
PLLFSVVLFPFL CP3B_MOUSE 218 18 -
PFFLSITIFPFI CP38_MACFA 218 18 -
PFLLSLIFFPFL CP3T_PIG 218 18 -
PLFLSIIFFPFL O97689 218 18 -
PLFLSVTLFPFL CP39_RAT 218 18 -
PFILSIILFPFL CP3S_BOVIN 218 18 -
PFVLSIKVFPFL CP37_HUMAN 218 18 -
PFVLSIKVFPFL Q9H241 218 18 -
PFLLSIVMFPFL CP3E_CAVPO 218 18 -
PFLLSVVIFPFL CP3H_CAVPO 218 18 -
PLVFSVVLFPFL Q9JMA7 218 18 -
PFILSIILFPFL CP3A_MESAU 218 18 -
PFLLLISLFPFL Q9HB53 218 18 -
PFLLLISLFPFL Q9HB54 218 18 -
PFLLLISLFPFL Q9HB55 218 18 -
PFLLSTVMFPFL CP3F_CAVPO 218 18 -
PLSLSVALFPFL CP3G_MOUSE 218 18 -
PLLFSVVLFPLL Q9EQW4 218 18 -
PLFLLVAFFPFL Q9DE99 218 18 -
PLFLAVAFFPFL Q9PVE8 217 18 -
PLFLAVAFFPFL Q98T91 218 18 -
PLFLLVALFPFT CP3R_ONCMY 219 18 -

Motif 6 width=11
Element Seqn Id St Int Rpt
KHRVDFLQLMI CP34_HUMAN 265 36 -
KHRVDFLQLMI CP3L_CALJA 266 36 -
KHRVDFLQLMI CP33_HUMAN 265 36 -
KHRLDFLQLMI CP35_HUMAN 266 36 -
KPRVDFLQLMI CP3O_SHEEP 266 36 -
KQRVDFLQLMI CP3D_MOUSE 266 36 -
KHRVDFLQLMM Q06884 264 36 -
KHRVDFLQLMM CP31_RAT 266 36 -
KHRVDFLQLMM CP3V_MESAU 265 36 -
KRRVDFLQLMI CP36_RABIT 264 36 -
KNRVDFLQLMM CP3I_RAT 266 36 -
KHRVDFLQLML CP32_RAT 266 36 -
KNRVDFLQLMM CP3P_MOUSE 266 36 -
KNRVDFLQLMM Q9QXK4 266 36 -
KHRVDFLQLMI CP3C_CANFA 266 36 -
KHRVDFLQLMM CP3B_MOUSE 266 36 -
KHRVDFLQLMI CP38_MACFA 266 36 -
KRRVDLLQLMI CP3T_PIG 266 36 -
THRVDFLQLMI O97689 266 36 -
KQRMDFLQLMI CP39_RAT 266 36 -
MNRVDLLQLMI CP3S_BOVIN 266 36 -
KHRVDFLQLMI CP37_HUMAN 266 36 -
KHRVDFLQLMI Q9H241 266 36 -
KQRVDFLQMML CP3E_CAVPO 266 36 -
KQRVNFLQMML CP3H_CAVPO 266 36 -
KHRVDFLQLMM Q9JMA7 266 36 -
KTRMDFFQLMM CP3A_MESAU 266 36 -
KHRVDFFQQMI Q9HB53 266 36 -
KHRVDFFQQMI Q9HB54 266 36 -
KHRVDFFQQMI Q9HB55 266 36 -
KQRVNFLQMML CP3F_CAVPO 266 36 -
KHRVDFIYLMM CP3G_MOUSE 266 36 -
KHRVDFLQLMM Q9EQW4 266 36 -
KSRIDFLQLMI Q9DE99 266 36 -
KSRVDFLQLMI Q9PVE8 265 36 -
KSRIDFLQLMI Q98T91 266 36 -
TNRVDFLQLMI CP3R_ONCMY 267 36 -