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PR01686

Identifier
EP450ICYP2D  [View Relations]  [View Alignment]  
Accession
PR01686
No. of Motifs
5
Creation Date
13-MAR-2002
Title
CYP2D P450 family signature
Database References
PRINTS; PR00385 P450; PR00463 EP450I
Literature References
1. NOMENCLATURE COMMITTEE OF THE INTERNATIONAL UNION OF BIOCHEMISTRY
Nomenclature of electron-transfer proteins. Recommendations 1989.
EUR.J.BIOCHEMISTRY 200 599-611 (1991).
 
2. NEBERT, D.W. AND GONZALEZ, F.J.
P450 genes: structure, evolution, and regulation.
ANNU.REV.BIOCHEMISTRY 56 945-993 (1987).
 
3. NELSON, D.R., KAMATAKI, T., WAXMAN, D.J., GUENGERICH, F.P., ESTABROOK,
R.W., FEYEREISEN, R., GONZALEZ, F.J., COON, M.J., GUNSALUS, I.C., GOTOH, O.,
OKUDA, K. AND NEBERT, D.W.
The P450 superfamily: update on new sequences, gene mapping, accession
numbers, early trivial names of enzymes, and nomenclature.
DNA CELL BIOL. 12 1-51 (1993).
 
4. GOTOH, O.
Evolution and differentiation of P-450 genes.
IN BIOCHEMISTRY T., 2ND ED., ISHIMURA, Y. AND FUJII-KURIYAMA, Y., EDS., 
KODANSHA, TOKYO, 1993, PP.255-272.
 
5. NELSON, D.R.
Cytochrome P450 homepage.
http://drnelson.utmem.edu/CytochromeP450.html
 
6. NELSON, D.R.
Metazoan Cytochrome P450 evolution.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY PART C 121 15-22 (1998).
 
7. LEWIS, D.F.V.
P450 substrate specificity and metabolism.
IN CYTOCHROMES P450: STRUCTURE, FUNCTION AND MECHANISM, TAYLOR AND FRANCIS
LTD., LONDON, 1996, PP.115-167.
 
8. DE GROOT, M.J., VERMEULEN, N.P.E. KRAMER, J.D., VAN ACKER, F.A.A. AND
DONNE-OP DEN KELDER, G.M. 
A three-dimensional protein model for human cytochrome P450 2D6 based on the
crystal structures of P450 101, P450 102, and P450 108.
CHEM.RES.TOXICOL. 9 1079-1091 (1996).

Documentation
P450 enzymes constitute a superfamily of haem-thiolate proteins [1], widely
distributed in bacteria, fungi, plants and animals. The enzymes are involved
in metabolism of a plethora of both exogenous and endogenous compounds [2].
Usually, they act as terminal oxidases in multi-component electron transfer
chains, called P450-containing monooxygenase systems.
 
Current P450 nomenclature, based on divergent evolution of the P450
superfamily, was proposed and developed by Nebert et al. [3]. On the basis
of sequence similarity, all P450s can be categorised into 2 main classes,
the so-called B- and E-classes: P450 proteins of prokaryotic 3-component
systems and fungal P450nor (CYP55) belong to the B-class; all other known
P450s from distinct systems are of the E-class [4]. E-class P450s may be
further divided into 5 subclasses (groups) according to protein sequence
similarities. The data suggest that divergence of the P450 superfamily 
into B- and E-classes, and further divergence into stable P450 groups 
within the E-class, must be very ancient and had occured before the 
appearance of eukaryotes. 
 
Due to the rapid increase in numbers of P450s, Nelson introduced the concept
of a higher order classification of P450 families into clans [3] based on
sequence similarity. This is similar to the previous grouping into B- and
E-classes; both classifications are still used. According to Nelson's
system, clan 2 contains the CYP2 plus CYP1, 17, 18, 21 and 71 families, and
corresponds to the E-class group I proteins [5,6]. Members of the first 4
families are of vertebrate origin, while those from CYP71 derive from plants.
CYP1 and CYP2 enzymes mainly metabolise exogenous substrates, whereas CYP17
and CYP21 are involved in metabolism of endogenous physiologically-active
compounds. 
 
The CYP2 family, comprising 15 subfamilies (A-H, J-N, P and Q), is the most
dominant in clan 2. Six of these subfamilies are non-mammalian: 2H derives
from chicken; 2K, 2M, 2N and 2P are from fish; 2L is from lobster; and 2Q
from Xenopus [5]. The first five (A-E) are present in mammalian liver, but
in differing amounts and with different inducibilities [7]. These five 
subfamilies show varied substrate specificities, with some degree of 
overlap. The 2D subfamily is generally regarded as being involved in 
detoxifying pathways of metabolism. There is considerable interest in the
2D subfamilies, due to the fact that about 30% of all currently-used
drugs are metabolised in man by the 2D6 orthologue. As the constitutive
levels of 2D6 are low (1-2% of human hepatic P450 complement) and the enzyme
is non-inducible, any defect in 2D6-dependent metabolism may have serious
consequences with respect to an undesirable accumulation of pharmaceutical
agents, leading to potential toxicity and possible adverse drug reactions
[7]. The CYP2D gene is located on chromosome 22 in mouse and man [3].
 
EP450ICYP2D is a 5-element fingerprint that provides a signature for the
CYP2D P450 family. The fingerprint was derived from an initial alignment of 
18 sequences: the motifs were drawn from conserved regions spanning the
N-terminal half of the alignment, focusing on those sections that
characterise the CYP2D proteins but distinguish them from the rest of the
CYP2 family - using the model of de Groot et al. [8], motif 1 lies in the
N-terminal membrane anchor domain; motif 2 encodes the E helix; motif 3 
spans part of the N-terminus of the G helix, and lies between substrate
recognition site (SRS) 2 and SRS 3; motif 4 spans the I helix and
part of SRS 4; and motif 5 encodes the haem-binding domain, including the
"aromatic region" typical of E-class P450s [4]. Two iterations on SPTR40_18f
were required to reach convergence, at which point a true set comprising 26
sequences was identified. A single partial match was also found, Q9DBF6,
a murine P450 that matches motifs 1, 3 and 4.
Summary Information
  26 codes involving  5 elements
0 codes involving 4 elements
1 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
52626262626
400000
310110
200000
12345
True Positives
CPD1_RAT      CPD2_RAT      CPD3_RAT      CPD4_RAT      
CPD5_RAT CPD6_HUMAN CPD9_MOUSE CPDA_MOUSE
CPDB_MOUSE CPDF_CANFA CPDG_CAVPO CPDH_MACFA
CPDI_RAT CPDJ_CALJA CPDK_MESAU CPDP_PIG
CPDR_MESAU CPDS_MESAU Q16753 Q29454
Q64529 Q64530 Q9DBJ5 Q9JKY7
Q9TUJ4 Q9TUJ5
True Positive Partials
Codes involving 3 elements
Q9DBF6
Sequence Titles
CPD1_RAT    Cytochrome P450 2D1 (EC 1.14.14.1) (CYPIID1) (P450-DB1) (P450-CMF1A) (P450-UT-7) (Debrisoquine 4-hydroxylase) - Rattus norvegicus (Rat). 
CPD2_RAT Cytochrome P450 2D2 (EC 1.14.14.1) (CYPIID2) (P450-DB2) (P450-CMF2) (Debrisoquine 4-hydroxylase) - Rattus norvegicus (Rat).
CPD3_RAT Cytochrome P450 2D3 (EC 1.14.14.1) (CYPIID3) (P450-DB3) (Debrisoquine 4-hydroxylase) - Rattus norvegicus (Rat).
CPD4_RAT Cytochrome P450 2D4 (EC 1.14.14.1) (CYPIID4) (P450-DB4) (P450-CMF3) (Debrisoquine 4-hydroxylase) - Rattus norvegicus (Rat).
CPD5_RAT Cytochrome P450 2D5 (EC 1.14.14.1) (CYPIID5) (P450-DB5) (P450-CMF1B) (Debrisoquine 4-hydroxylase) - Rattus norvegicus (Rat).
CPD6_HUMAN Cytochrome P450 2D6 (EC 1.14.14.1) (CYPIID6) (P450-DB1) (Debrisoquine 4-hydroxylase) - Homo sapiens (Human).
CPD9_MOUSE Cytochrome P450 2D9 (EC 1.14.14.1) (CYPIID9) (P450-16-alpha) (CA) (Testosterone 16-alpha hydroxylase) - Mus musculus (Mouse).
CPDA_MOUSE Cytochrome P450 2D10 (EC 1.14.14.1) (CYPIID10) (P450-16-alpha) (P450CB) (Testosterone 16-alpha hydroxylase) - Mus musculus (Mouse).
CPDB_MOUSE Cytochrome P450 2D11 (EC 1.14.14.1) (CYPIID11) (P450-16-alpha) (CC) (Testosterone 16-alpha hydroxylase) - Mus musculus (Mouse).
CPDF_CANFA Cytochrome P450 2D15 (EC 1.14.14.1) (CYPIID15) (P450 DUT2) - Canis familiaris (Dog).
CPDG_CAVPO Cytochrome P450 2D16 (EC 1.14.14.1) (CYPIID16) - Cavia porcellus (Guinea pig).
CPDH_MACFA Cytochrome P450 2D17 (EC 1.14.14.1) (CYPIID17) - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
CPDI_RAT Cytochrome P450 2D18 (EC 1.14.14.1) (CYPIID18) (P450 2D-29/2D-35) - Rattus norvegicus (Rat).
CPDJ_CALJA Cytochrome P450 2D19 (EC 1.14.14.1) (CYPIID19) (P450 CM2D-1) - Callithrix jacchus (Common marmoset).
CPDK_MESAU Cytochrome P450 2D20 (EC 1.14.14.-) (CYPIID20) - Mesocricetus auratus (Golden hamster).
CPDP_PIG Cytochrome P450 2D25 (EC 1.14.14.-) (CYPIID25) (Vitamin D(3) 25- hydroxylase) - Sus scrofa (Pig).
CPDR_MESAU Cytochrome P450 2D27 (EC 1.14.14.-) (CYPIID27) - Mesocricetus auratus (Golden hamster).
CPDS_MESAU Cytochrome P450 2D28 (EC 1.14.14.-) (CYPIID28) - Mesocricetus auratus (Golden hamster).
Q16753 DEBRISOQUINE 4-HYDROXYLASE MUTANT ALLELE (EC 1.14.14.1) - Homo sapiens (Human).
Q29454 CYTOCHROME P450 IID (EC 1.14.14.1) - Bos taurus (Bovine).
Q64529 CYTOCHROME P450 16A-MS1 (EC 1.14.14.1) - Mus spretus (Western wild mouse).
Q64530 CYTOCHROME P450 16A-MS2 (EC 1.14.14.1) - Mus spretus (Western wild mouse).
Q9DBJ5 1300006E06RIK PROTEIN - Mus musculus (Mouse).
Q9JKY7 CYTOCHROME P450 CYP2D22 - Mus musculus (Mouse).
Q9TUJ4 CYTOCHROME P450 2D/II - Oryctolagus cuniculus (Rabbit).
Q9TUJ5 CYTOCHROME P450 2D/I - Oryctolagus cuniculus (Rabbit).

Q9DBF6 1300013D18RIK PROTEIN - Mus musculus (Mouse).
Scan History
SPTR40_18f 2  125  NSINGLE    
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
VIFILLVDLMHRR CPD3_RAT 17 17 -
VIFILLVDLMHRR CPD1_RAT 17 17 -
AIFLLLVDLMHRR CPDH_MACFA 14 14 -
ALFLLLVDLMHRR CPDR_MESAU 17 17 -
AIFLLLVDLMHRR CPD6_HUMAN 14 14 -
IIFLLLVDLMHRR CPD4_RAT 17 17 -
IIFLLLVDLMHRR CPDI_RAT 17 17 -
VIFILLVDLMHRH CPD5_RAT 17 17 -
AIFLLLVDLVHRH CPD2_RAT 17 17 -
AIFVLLVDLMHRR CPDJ_CALJA 14 14 -
VIFILLVDLMHRH CPDA_MOUSE 17 17 -
ALFLLLVDLMHRR CPDK_MESAU 17 17 -
AIFLLLVDLMHRR CPDG_CAVPO 17 17 -
VIFLLLVDLMHRR CPDP_PIG 16 16 -
VIFILLVDLMHRH CPDB_MOUSE 17 17 -
VILILLVDLLHRR CPDS_MESAU 17 17 -
VIFILLVDLTHQR CPD9_MOUSE 17 17 -
AIFLLLVDLMHRR CPDF_CANFA 16 16 -

Motif 2 width=13
Element Seqn Id St Int Rpt
LLNKAVCNVIASL CPD3_RAT 180 150 -
MLNKALCNVIASL CPD1_RAT 180 150 -
LLDKAVSNVIASL CPDH_MACFA 177 150 -
LLNKSVCNVISSL CPDR_MESAU 180 150 -
LLDKAVSNVIASL CPD6_HUMAN 177 150 -
LLDKAVCNVIASL CPD4_RAT 180 150 -
LLDKAVCNVIASL CPDI_RAT 180 150 -
MLNKALCNVIASL CPD5_RAT 180 150 -
LLSKAVSNVIASL CPD2_RAT 180 150 -
LLDKAVSNVIASL CPDJ_CALJA 177 150 -
MLNNAVCNVIASL CPDA_MOUSE 180 150 -
LLNKSVCNVISSL CPDK_MESAU 180 150 -
LLNKAVCNVISSL CPDG_CAVPO 180 150 -
LLNKAVSNVIASL CPDP_PIG 179 150 -
MLNKSTCNVIASL CPDB_MOUSE 180 150 -
LLNKAVCNVITSL CPDS_MESAU 180 150 -
MLNKSTCNVIASL CPD9_MOUSE 180 150 -
LLNKAVSNVISSL CPDF_CANFA 179 150 -

Motif 3 width=14
Element Seqn Id St Int Rpt
VLNMFPVLLRIPGL CPD3_RAT 226 33 -
VLNTFPALLRIPGL CPD1_RAT 226 33 -
VLNAIPLLLRIPGL CPDH_MACFA 223 33 -
VLNAVPVLLRIPGL CPDR_MESAU 226 33 -
VLNAVPVLLHIPAL CPD6_HUMAN 223 33 -
LLNVFPMLLHIPGL CPD4_RAT 226 33 -
LLNVFPMLLHIPGL CPDI_RAT 226 33 -
VLNTFPALLRIPGL CPD5_RAT 226 33 -
VLNAIPILLQIPGL CPD2_RAT 226 33 -
VLNAIPVLLRIPGL CPDJ_CALJA 223 33 -
VLNMFPILLRIPGL CPDA_MOUSE 226 33 -
VLNAVPVLLRIPGL CPDK_MESAU 226 33 -
VLNSIPLLLRIPCV CPDG_CAVPO 226 33 -
VLEAMPVLRHIPGL CPDP_PIG 225 33 -
VLNEFPIFLRIPGL CPDB_MOUSE 226 33 -
ILNTFPVLLHIPGL CPDS_MESAU 226 33 -
VLNAFPILLRIPRL CPD9_MOUSE 226 33 -
ALNSIPVLLHIPGL CPDF_CANFA 225 33 -

Motif 4 width=12
Element Seqn Id St Int Rpt
SSFNDANLRLVV CPD3_RAT 291 51 -
SSFNDENLRMVV CPD1_RAT 291 51 -
SSFNEENLRMVV CPDH_MACFA 288 51 -
SSFNDENLRMVV CPDR_MESAU 291 51 -
SSFNDENLRIVV CPD6_HUMAN 288 51 -
SSFNDENLRVVV CPD4_RAT 291 51 -
SSFNDENLRVVV CPDI_RAT 291 51 -
SSFNDENLRMVV CPD5_RAT 291 51 -
SSFNDENLRLVV CPD2_RAT 291 51 -
SSFNDENLHLVV CPDJ_CALJA 288 51 -
SSFNDENLRMVV CPDA_MOUSE 291 51 -
SSFNDENLHVVV CPDK_MESAU 291 51 -
SSFNDENLRLLV CPDG_CAVPO 291 51 -
SSFNDENLRLVV CPDP_PIG 290 51 -
SSFNDENLRMVV CPDB_MOUSE 291 51 -
SSFNDQNLRMVV CPDS_MESAU 291 51 -
SSFNDENLLMVV CPD9_MOUSE 291 51 -
TSFNEENLCMVT CPDF_CANFA 290 51 -

Motif 5 width=15
Element Seqn Id St Int Rpt
NLSSVLKDETVWEKP CPD3_RAT 401 98 -
NLSSVLKDETVWEKP CPD1_RAT 401 98 -
NLSSVLKDEAVWEKP CPDH_MACFA 398 98 -
NLSSVLKDETVWEKP CPDR_MESAU 401 98 -
NLSSVLKDEAVWEKP CPD6_HUMAN 398 98 -
NLSSVLKDETVWEKP CPD4_RAT 401 98 -
NLSSVLKDETVWEKP CPDI_RAT 401 98 -
NLSSVLKDETVWEKP CPD5_RAT 401 98 -
NLSSVLKDETVWEKP CPD2_RAT 401 98 -
NLSSVLKDEANWEKP CPDJ_CALJA 398 98 -
NMSSVLKDETVWEKP CPDA_MOUSE 401 98 -
NLSSVLKDETVWEKP CPDK_MESAU 401 98 -
NLSSVLKDETVWEKP CPDG_CAVPO 401 98 -
NLTSVLKDETVWKKP CPDP_PIG 400 98 -
NLSSVLKGETVWEKP CPDB_MOUSE 402 99 -
NLSSVLKDETVWEKP CPDS_MESAU 401 98 -
NMSSMLKDESVWEKP CPD9_MOUSE 401 98 -
NLSSVLKDEKVWKKP CPDF_CANFA 400 98 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
VIFILLVDLMHRR CPD3_RAT 17 17 -
VIFILLVDLMHRR CPD1_RAT 17 17 -
AIFLLLVDLMHRR CPDH_MACFA 14 14 -
ALFLLLVDLMHRR CPDR_MESAU 17 17 -
AIFLLLVDLMHKR Q9TUJ4 17 17 -
AIFLLLVDLMHRR CPD6_HUMAN 14 14 -
AIFLLLVDLMHRR Q16753 14 14 -
IIFLLLVDLMHRR CPD4_RAT 17 17 -
IIFLLLVDLMHRR CPDI_RAT 17 17 -
VIFILLVDLMHRH CPD5_RAT 17 17 -
AIFLLLVDLVHRH CPD2_RAT 17 17 -
AIFLLLVDLVHRR Q9DBJ5 17 17 -
AIFVLLVDLMHRR CPDJ_CALJA 14 14 -
VIFILLVDLMHRH CPDA_MOUSE 17 17 -
ALFLLLVDLMHRR CPDK_MESAU 17 17 -
AIFLLLVDLMHKR Q9TUJ5 17 17 -
AIFLLLVDLMHRR CPDG_CAVPO 17 17 -
VIFLLLVDLMHRR CPDP_PIG 16 16 -
LIFLLLLDLMHRR Q29454 17 17 -
VIFILLVDLTHQR Q64530 17 17 -
VIFILLVDLMHRH CPDB_MOUSE 17 17 -
VILILLVDLLHRR CPDS_MESAU 17 17 -
VIFLILVNLMHWR Q9JKY7 17 17 -
VIFILLVDLTHQR CPD9_MOUSE 17 17 -
VIFILLVVLTHQR Q64529 17 17 -
AIFLLLVDLMHRR CPDF_CANFA 16 16 -

Motif 2 width=13
Element Seqn Id St Int Rpt
LLNKAVCNVIASL CPD3_RAT 180 150 -
MLNKALCNVIASL CPD1_RAT 180 150 -
LLDKAVSNVIASL CPDH_MACFA 177 150 -
LLNKSVCNVISSL CPDR_MESAU 180 150 -
LLNKAVCNVIASL Q9TUJ4 180 150 -
LLDKAVSNVIASL CPD6_HUMAN 177 150 -
LLDKAVSNVIASL Q16753 180 153 -
LLDKAVCNVIASL CPD4_RAT 180 150 -
LLDKAVCNVIASL CPDI_RAT 180 150 -
MLNKALCNVIASL CPD5_RAT 180 150 -
LLSKAVSNVIASL CPD2_RAT 180 150 -
LLSKAVSNVIASL Q9DBJ5 180 150 -
LLDKAVSNVIASL CPDJ_CALJA 177 150 -
MLNNAVCNVIASL CPDA_MOUSE 180 150 -
LLNKSVCNVISSL CPDK_MESAU 180 150 -
LLNKAIGNVIASL Q9TUJ5 180 150 -
LLNKAVCNVISSL CPDG_CAVPO 180 150 -
LLNKAVSNVIASL CPDP_PIG 179 150 -
LLNKAVSNVIASL Q29454 180 150 -
MLNNAVCNVIASL Q64530 180 150 -
MLNKSTCNVIASL CPDB_MOUSE 180 150 -
LLNKAVCNVITSL CPDS_MESAU 180 150 -
LLDKAVCNVIASL Q9JKY7 180 150 -
MLNKSTCNVIASL CPD9_MOUSE 180 150 -
MLNKSTCNVIASL Q64529 180 150 -
LLNKAVSNVISSL CPDF_CANFA 179 150 -

Motif 3 width=14
Element Seqn Id St Int Rpt
VLNMFPVLLRIPGL CPD3_RAT 226 33 -
VLNTFPALLRIPGL CPD1_RAT 226 33 -
VLNAIPLLLRIPGL CPDH_MACFA 223 33 -
VLNAVPVLLRIPGL CPDR_MESAU 226 33 -
VLNVIPILLRIPGL Q9TUJ4 226 33 -
VLNAVPVLLHIPAL CPD6_HUMAN 223 33 -
VLNAVPVLLHIPAL Q16753 226 33 -
LLNVFPMLLHIPGL CPD4_RAT 226 33 -
LLNVFPMLLHIPGL CPDI_RAT 226 33 -
VLNTFPALLRIPGL CPD5_RAT 226 33 -
VLNAIPILLQIPGL CPD2_RAT 226 33 -
VLNAIPMLLHIPGL Q9DBJ5 226 33 -
VLNAIPVLLRIPGL CPDJ_CALJA 223 33 -
VLNMFPILLRIPGL CPDA_MOUSE 226 33 -
VLNAVPVLLRIPGL CPDK_MESAU 226 33 -
VLNVIPILLRIPGL Q9TUJ5 226 33 -
VLNSIPLLLRIPCV CPDG_CAVPO 226 33 -
VLEAMPVLRHIPGL CPDP_PIG 225 33 -
VVEAVPVLLSIPGL Q29454 226 33 -
VLNAFPIFLRIPGL Q64530 226 33 -
VLNEFPIFLRIPGL CPDB_MOUSE 226 33 -
ILNTFPVLLHIPGL CPDS_MESAU 226 33 -
FLNVFPMLLRIPGL Q9JKY7 226 33 -
VLNAFPILLRIPRL CPD9_MOUSE 226 33 -
VLNAFPILLRIPRL Q64529 226 33 -
ALNSIPVLLHIPGL CPDF_CANFA 225 33 -

Motif 4 width=12
Element Seqn Id St Int Rpt
SSFNDANLRLVV CPD3_RAT 291 51 -
SSFNDENLRMVV CPD1_RAT 291 51 -
SSFNEENLRMVV CPDH_MACFA 288 51 -
SSFNDENLRMVV CPDR_MESAU 291 51 -
SSFNDDNLRLVV Q9TUJ4 291 51 -
SSFNDENLRIVV CPD6_HUMAN 288 51 -
SSFNDENLRIVV Q16753 291 51 -
SSFNDENLRVVV CPD4_RAT 291 51 -
SSFNDENLRVVV CPDI_RAT 291 51 -
SSFNDENLRMVV CPD5_RAT 291 51 -
SSFNDENLRLVV CPD2_RAT 291 51 -
SSFNDKNLRIVV Q9DBJ5 291 51 -
SSFNDENLHLVV CPDJ_CALJA 288 51 -
SSFNDENLRMVV CPDA_MOUSE 291 51 -
SSFNDENLHVVV CPDK_MESAU 291 51 -
SSFNDDNLRLVV Q9TUJ5 291 51 -
SSFNDENLRLLV CPDG_CAVPO 291 51 -
SSFNDENLRLVV CPDP_PIG 290 51 -
SSFNDENLRLVV Q29454 291 51 -
SSFNHENLRMVV Q64530 291 51 -
SSFNDENLRMVV CPDB_MOUSE 291 51 -
SSFNDQNLRMVV CPDS_MESAU 291 51 -
SSFNDENLRTVV Q9JKY7 291 51 -
SSFNDENLLMVV CPD9_MOUSE 291 51 -
SSFNDENLLIVV Q64529 291 51 -
TSFNEENLCMVT CPDF_CANFA 290 51 -

Motif 5 width=15
Element Seqn Id St Int Rpt
NLSSVLKDETVWEKP CPD3_RAT 401 98 -
NLSSVLKDETVWEKP CPD1_RAT 401 98 -
NLSSVLKDEAVWEKP CPDH_MACFA 398 98 -
NLSSVLKDETVWEKP CPDR_MESAU 401 98 -
NLSSVLKDEAVWEKP Q9TUJ4 401 98 -
NLSSVLKDEAVWEKP CPD6_HUMAN 398 98 -
NLSSVLKDEAVWEKP Q16753 401 98 -
NLSSVLKDETVWEKP CPD4_RAT 401 98 -
NLSSVLKDETVWEKP CPDI_RAT 401 98 -
NLSSVLKDETVWEKP CPD5_RAT 401 98 -
NLSSVLKDETVWEKP CPD2_RAT 401 98 -
NLSSVLKDETVWEKP Q9DBJ5 401 98 -
NLSSVLKDEANWEKP CPDJ_CALJA 398 98 -
NMSSVLKDETVWEKP CPDA_MOUSE 401 98 -
NLSSVLKDETVWEKP CPDK_MESAU 401 98 -
NLSSVLKDEAVWEKP Q9TUJ5 401 98 -
NLSSVLKDETVWEKP CPDG_CAVPO 401 98 -
NLTSVLKDETVWKKP CPDP_PIG 400 98 -
NLSSVLKDETVWEKP Q29454 401 98 -
NLSSVLKDETVWEKP Q64530 401 98 -
NLSSVLKGETVWEKP CPDB_MOUSE 402 99 -
NLSSVLKDETVWEKP CPDS_MESAU 401 98 -
NLSSALKDETVWEKP Q9JKY7 401 98 -
NMSSMLKDESVWEKP CPD9_MOUSE 401 98 -
NMSSMLKDETVWEKP Q64529 401 98 -
NLSSVLKDEKVWKKP CPDF_CANFA 400 98 -