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PR01683

Identifier
EP450ICYP1A  [View Relations]  [View Alignment]  
Accession
PR01683
No. of Motifs
5
Creation Date
13-MAR-2002
Title
CYP1A P450 family signature
Database References
PRINTS; PR00385 P450; PR00463 EP450I
Literature References
1. NOMENCLATURE COMMITTEE OF THE INTERNATIONAL UNION OF BIOCHEMISTRY
Nomenclature of electron-transfer proteins. Recommendations 1989.
EUR.J.BIOCHEMISTRY 200 599-611 (1991).
 
2. NEBERT, D.W. AND GONZALEZ, F.J.
P450 genes: structure, evolution, and regulation.
ANNU.REV.BIOCHEMISTRY 56 945-993 (1987).
 
3. NELSON, D.R., KAMATAKI, T., WAXMAN, D.J., GUENGERICH, F.P., ESTABROOK,
R.W., FEYEREISEN, R., GONZALEZ, F.J., COON, M.J., GUNSALUS, I.C., GOTOH, O.,
OKUDA, K. AND NEBERT, D.W.
The P450 superfamily: update on new sequences, gene mapping, accession
numbers, early trivial names of enzymes, and nomenclature.
DNA CELL BIOL. 12 1-51 (1993).
 
4. GOTOH, O.
Evolution and differentiation of P-450 genes.
IN BIOCHEMISTRY T., 2ND ED., ISHIMURA, Y. AND FUJII-KURIYAMA, Y., EDS., 
KODANSHA, TOKYO, 1993, PP.255-272.
 
5. SZKLARZ, G.D., HE, Y.A. AND HALPERT, J.R.
Site-directed mutagenesis as a tool for molecular modeling of cytochrome
P450 2B1.
BIOCHEMISTRY 34 14312-14322 (1995).
 
6. NELSON, D.R.
Cytochrome P450 homepage.
http://drnelson.utmem.edu/CytochromeP450.html
 
7. NELSON, D.R.
Metazoan cytochrome P450 evolution.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY PART C 121 15-22 (1998).
 
8. LEWIS, D.F.V.
P450 substrate specificity and metabolism.
IN CYTOCHROMES P450: STRUCTURE, FUNCTION AND MECHANISM, TAYLOR AND FRANCIS
LTD., LONDON, 1996, PP.115-167.

Documentation
P450 enzymes constitute a superfamily of haem-thiolate proteins [1], widely
distributed in bacteria, fungi, plants and animals. The enzymes are involved
in metabolism of a plethora of both exogenous and endogenous compounds [2].
Usually, they act as terminal oxidases in multi-component electron transfer
chains, called P450-containing monooxygenase systems.
 
Current P450 nomenclature, based on divergent evolution of the P450
superfamily, was proposed and developed by Nebert et al. [3]. On the basis
of sequence similarity, all P450s can be categorised into 2 main classes,
the so-called B- and E-classes: P450 proteins of prokaryotic 3-component
systems and fungal P450nor (CYP55) belong to the B-class; all other known
P450s from distinct systems are of the E-class [4]. E-class P450s may be
further divided into 5 subclasses (groups) according to protein sequence
similarities. The data suggest that divergence of the P450 superfamily 
into B- and E-classes, and further divergence into stable P450 groups 
within the E-class, must be very ancient and had occured before the 
appearance of eukaryotes. 
 
Due to the rapid increase in numbers of P450s, Nelson introduced the concept
of a higher order classification of P450 families into clans [6,7] based on
sequence similarity. This is similar to the previous grouping into B- and
E-classes; both classifications are still used. According to Nelson's
system, clan 2 contains the CYP1 plus CYP2, 17, 18, 21 and 71 families, and
corresponds to the E-class group I proteins [7]. Members of the first 4
families are of vertebrate origin, while those from CYP71 derive from plants.
 
CYP1 enzymes mainly metabolise exogenous substrates and are found in 
mammalia (1A, 1B), bony fishes (1A), sharks, skates, rays (1A) and birds
(1A). CYP1A contains five proteins, namely, CYP1A1, 1A2, 1A3, 1A4 and 1A5.
CYP1A1 and CYP1A2 have been found in all classes of the animal kingdom [3];
the proteins are highly similar between mammalian species (human and rat
CYP1A1 are 80% identical) and CYP1A1 and CYP1A2 are themselves closely
related. CYP1 family members are closely associated with the metabolic
activation of pro-carcinogens and mutagens [8]. The mechanisms of activation
have been extensively studied, and are known to involve 'bay-region' 
epoxidation in conformationally hindered positions, often followed by a 
second epoxidation step on the subsequent 'bay-region' diol to give rise to
electrophilic diol epoxides capable of interacting covalently with DNA. This
causes mutagenesis and utimately, carcinogenesis. Clearly, the CYP1 family
has a role in toxic activation, but it may also possess important endogenous
functions, in addition to mediating several detoxifying pathways.
 
EP450ICYP1A is a 5-element fingerprint that provides a signature for the
CYP1A P450 family. The fingerprint was derived from an initial alignment of
32 sequences: the motifs were drawn from conserved regions spanning the
N-terminal half of the alignment, focusing on those sections that
characterise the CYP1A proteins but distinguish them from the rest of the
P450 superfamily - using the model of Szklarz et al. [5], motif 1 spans the
N-terminal membrane anchor domain; motif 2 encodes the B' helix, and 
represents the first of the substrate recognition sites (SRS) 1; motif 3
lies between the F and G helices; motif 4 encodes the well-conserved H 
helix; and motif 5 spans the C-terminus of helix I. Two iterations on
SPTR40_18f were required to reach convergence, at which point a true set
comprising 43 sequences was identified. Two partial matches were also found:
Q28716 and Q9YI88, both of which are close family members that fail to make
significant matches with one of the motifs.
Summary Information
  43 codes involving  5 elements
2 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
54343434343
411222
300000
200000
12345
True Positives
CP11_CANFA    CP11_CAVPO    CP11_HUMAN    CP11_LIZSA    
CP11_MACFA CP11_MESAU CP11_MICTO CP11_MOUSE
CP11_OPSTA CP11_PAGMA CP11_PLAFE CP11_PLEPL
CP11_RABIT CP11_RAT CP11_SHEEP CP11_SPAAU
CP11_STECH CP12_CANFA CP12_CAVPO CP12_HUMAN
CP12_MESAU CP12_MOUSE CP12_RABIT CP12_RAT
CP14_CHICK CP15_CHICK O42231 O42430
O77809 O77810 P79716 Q92039
Q92109 Q92110 Q9BXX7 Q9PRH3
Q9PT96 Q9PTY4 Q9PTY6 Q9PTY7
Q9UK49 Q9YI64 Q9YI89
True Positive Partials
Codes involving 4 elements
Q28716 Q9YI88
Sequence Titles
CP11_CANFA  Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (DAH1) - Canis familiaris (Dog). 
CP11_CAVPO Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) - Cavia porcellus (Guinea pig).
CP11_HUMAN Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450-P1) (P450 form 6) (P450-C) - Homo sapiens (Human).
CP11_LIZSA Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) - Liza saliens (Leaping mullet).
CP11_MACFA Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
CP11_MESAU Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P-450MC) - Mesocricetus auratus (Golden hamster).
CP11_MICTO Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) - Microgadus tomcod (Atlantic tomcod).
CP11_MOUSE Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450-P1) - Mus musculus (Mouse).
CP11_OPSTA Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) - Opsanus tau (Oyster toadfish).
CP11_PAGMA Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) - Pagrus major (Red sea bream) (Chrysophrys major).
CP11_PLAFE Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) - Platichthys flesus (European flounder).
CP11_PLEPL Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) - Pleuronectes platessa (Plaice).
CP11_RABIT Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450 isozyme 6) (P-450 PHPAH1) (P450 LM6) - Oryctolagus cuniculus (Rabbit).
CP11_RAT Cytochrome P450 1A1 (EC 1.14.14.1) (CYP1A1) (CYPIA1) (P450-C) (P450MT2) - Rattus norvegicus (Rat).
CP11_SHEEP Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450-C) (P4501A1) - Ovis aries (Sheep).
CP11_SPAAU Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) - Sparus aurata (Gilthead sea bream).
CP11_STECH Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) - Stenotomus chrysops (Scup).
CP12_CANFA Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (DAH2) (Cytochrome P450- D2) - Canis familiaris (Dog).
CP12_CAVPO Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) - Cavia porcellus (Guinea pig).
CP12_HUMAN Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (P450-P3) (P(3)450) (P450 4) - Homo sapiens (Human).
CP12_MESAU Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (P450-MC4) (Hepatic cytochrome P-450MC1) - Mesocricetus auratus (Golden hamster).
CP12_MOUSE Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (P450-P2/P450-P3) - Mus musculus (Mouse).
CP12_RABIT Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (P450 isozyme 4) (P450- PM4) (P450 LM4) - Oryctolagus cuniculus (Rabbit).
CP12_RAT Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (P450-D) (P-448) - Rattus norvegicus (Rat).
CP14_CHICK Cytochrome P450 1A4 (EC 1.14.14.1) (CYPIA4) (P450 TCDDAHH) - Gallus gallus (Chicken).
CP15_CHICK Cytochrome P450 1A5 (EC 1.14.14.1) (CYPIA5) (P450 TCDDAA) - Gallus gallus (Chicken).
O42231 CYTOCHROME P4501A1 - LIZA AURATA.
O42430 CYP1A - LIMANDA LIMANDA (DAB).
O77809 CYTOCHROME P-450 - Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
O77810 CYTOCHROME P-450 - Callithrix jacchus (Common marmoset).
P79716 CYTOCHROME P450 1A1 (EC 1.14.14.1) (CYPIA1) - DICENTRARCHUS LABRAX (EUROPEAN SEA BASS).
Q92039 CYTOCHROME P450 (EC 1.14.14.1) - CHAETODON CAPISTRATUS (FOUR-EYE BUTTERFLYFISH).
Q92109 CYP1A1=3-METHYLCHOLANTHRENE RESPONSIVE GENE (EC 1.14.14.1) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI).
Q92110 CYTOCHROME P450 (CYP1A2) (EC 1.14.14.1) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI).
Q9BXX7 CYTOCHROME P450 - Homo sapiens (Human).
Q9PRH3 CYTOCHROME P450 1A3 - Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
Q9PT96 CYTOCHROME P450 1A - Dicentrarchus labrax (European sea bass).
Q9PTY4 CYTOCHROME P450 1A - Anguilla japonica (Japanese eel).
Q9PTY6 CYTOCHROME P4501A1 - Anguilla japonica (Japanese eel).
Q9PTY7 CYTOCHROME P450 1A1 - Anguilla japonica (Japanese eel).
Q9UK49 CYTOCHROME P450-1A2 (EC 1.14.14.1) - Homo sapiens (Human).
Q9YI64 CYP1A - Fundulus heteroclitus (Killifish) (Mummichog).
Q9YI89 CYTOCHROME P450 - Xenopus laevis (African clawed frog).

Q28716 CYTOCHROME P450 - Oryctolagus cuniculus (Rabbit).
Q9YI88 CYTOCHROME P450 - Xenopus laevis (African clawed frog).
Scan History
SPTR40_18f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
LVAMTTVCLVYLI O42430 18 18 -
LVALVTVCLVYLI O42231 18 18 -
LVAMTTMCLVYLI CP11_PLAFE 18 18 -
LVAMTTMCLVYLI CP11_PLEPL 18 18 -
LVAVVTVCLVYLI CP11_LIZSA 18 18 -
LLAVTTFCLGFWV CP11_RAT 17 17 -
LVAIITMCLVYMI CP11_SPAAU 18 18 -
LLASLIFCLVFWV CP11_MACFA 13 13 -
LLASVIFCLVFWV CP11_HUMAN 13 13 -
LVAMITMCLAYLI CP11_STECH 18 18 -
LLAVTVFCLGFWV CP11_MOUSE 17 17 -
LVALTAVCLVYLI Q92039 18 18 -
LVAIVTLCLVYML Q92110 18 18 -
LLASAVFCLVFWV CP11_SHEEP 20 20 -
LLAITVFCLGFWV CP11_MESAU 17 17 -
LLASAVFCLVFWV CP11_RABIT 17 17 -
LLTATIFCLVLWV CP11_CAVPO 9 9 -
LVAMVTLCLVYMI Q92109 18 18 -
LLASTVFCLVLWV CP11_CANFA 17 17 -
LVAMITVCMIYML CP11_MICTO 18 18 -
LLASAIFCLVFWV CP12_HUMAN 15 15 -
LVAAATFCLLLLL CP15_CHICK 22 22 -
LVAAATFCLLLLL CP15_CHICK 22 22 -
LVALITICVVYLI CP11_OPSTA 18 18 -
LLVSAVFCLVFWA CP12_RABIT 14 14 -
LLATAIFCLVFWV CP12_RAT 14 14 -
LLATAIFCLVFWM CP12_MOUSE 14 14 -
LLASTIFCLILWV CP12_CANFA 10 10 -
LLTATIFYLVLWV CP12_CAVPO 15 15 -
VLATAIFCIVFWV CP12_MESAU 14 14 -
LVAAATFCLLLLL CP14_CHICK 24 24 -

Motif 2 width=10
Element Seqn Id St Int Rpt
PDLYSFRFIN O42430 112 81 -
PDLYSFRFIS O42231 112 81 -
PDLYSFRFIN CP11_PLAFE 112 81 -
PDLYSFRFIN CP11_PLEPL 112 81 -
PDLYSFRFIS CP11_LIZSA 112 81 -
PDLYSFTLIA CP11_RAT 111 81 -
PDLYSFRFIN CP11_SPAAU 112 81 -
PNLYSFTLIS CP11_MACFA 107 81 -
PDLYTFTLIS CP11_HUMAN 107 81 -
PDLYSFRFIN CP11_STECH 112 81 -
PDLYSFTLIT CP11_MOUSE 111 81 -
PDLYSFTFIN Q92039 112 81 -
PDLYSFKFIN Q92110 112 81 -
PDLYSFTLVS CP11_SHEEP 114 81 -
PDFYSFTLIT CP11_MESAU 111 81 -
PDLYSFSFVT CP11_RABIT 111 81 -
PDLYSFTFIS CP11_CAVPO 103 81 -
SDLYSFKFIN Q92109 112 81 -
PDLYSFSLVT CP11_CANFA 111 81 -
PDLYSFQFIN CP11_MICTO 109 78 -
PDLYTSTLIT CP12_HUMAN 109 81 -
PDLYSFRHIT CP15_CHICK 116 81 -
PDLYSFRHIT CP15_CHICK 116 81 -
PDLYTFQFIS CP11_OPSTA 112 81 -
PDLYSSSFIT CP12_RABIT 108 81 -
PDLYSFTLIT CP12_RAT 108 81 -
PDLYSFTLIT CP12_MOUSE 108 81 -
PDLYSLSLIT CP12_CANFA 104 81 -
PDLYSSTFIS CP12_CAVPO 109 81 -
PDLYSFTLIT CP12_MESAU 108 81 -
PDLPSWQYVS CP14_CHICK 118 81 -

Motif 3 width=11
Element Seqn Id St Int Rpt
DFIPILQYLPS O42430 240 118 -
DFIPILQYLPN O42231 240 118 -
DFIPILQYLPS CP11_PLAFE 240 118 -
DFIPILQYLPS CP11_PLEPL 240 118 -
DFIPILQYLPN CP11_LIZSA 240 118 -
DFIPILRYLPN CP11_RAT 239 118 -
DFIPILQYLPS CP11_SPAAU 240 118 -
DFIPILRYLPN CP11_MACFA 235 118 -
DFIPILRYLPN CP11_HUMAN 235 118 -
DFIPILQYLPS CP11_STECH 240 118 -
DFIPVLRYLPN CP11_MOUSE 239 118 -
DFINILRFLPS Q92039 240 118 -
DFIPILRYLPN Q92110 240 118 -
DFIPVLRYLPN CP11_SHEEP 242 118 -
DFIPILRYLPN CP11_MESAU 239 118 -
DFFLILRYLPN CP11_RABIT 239 118 -
DFIPILRYLPS CP11_CAVPO 231 118 -
DFIPILRYLPN Q92109 240 118 -
DFFPILRYLPN CP11_CANFA 239 118 -
DFIPLLRFLPN CP11_MICTO 236 117 -
DFFPILRYLPN CP12_HUMAN 237 118 -
DFIPLLRYLPS CP15_CHICK 244 118 -
DFIPLLRYLPS CP15_CHICK 244 118 -
DFIPVLRFLPS CP11_OPSTA 240 118 -
DFFPILRYLPN CP12_RABIT 236 118 -
DFFPVLRYLPN CP12_RAT 236 118 -
DFFPVLRYLPN CP12_MOUSE 236 118 -
DFFPILQYMPN CP12_CANFA 232 118 -
DFFPILRYLPN CP12_CAVPO 237 118 -
DFFPILRYLPN CP12_MESAU 236 118 -
DFIPLLRYLPN CP14_CHICK 246 118 -

Motif 4 width=11
Element Seqn Id St Int Rpt
IRDITDSLIDH O42430 283 32 -
IRDITDSLIDH O42231 283 32 -
IRDITDSLIDH CP11_PLAFE 283 32 -
IRDITDSLIDH CP11_PLEPL 283 32 -
IRDITDSLIDH CP11_LIZSA 283 32 -
IRDITDSLIEH CP11_RAT 282 32 -
IRDITDSLIDH CP11_SPAAU 283 32 -
IRDITDSLIEH CP11_MACFA 278 32 -
IRDITDSLIEH CP11_HUMAN 278 32 -
IRDITDSLIDH CP11_STECH 283 32 -
IRDITDSLIEH CP11_MOUSE 282 32 -
IRDITDSLIDH Q92039 283 32 -
IRDITDSLIDH Q92110 283 32 -
IRDITDSLIEH CP11_SHEEP 285 32 -
IRDITDSLIEH CP11_MESAU 282 32 -
IRDITDSLIKH CP11_RABIT 282 32 -
IRDITDSLIEH CP11_CAVPO 274 32 -
IRDITDSLIDH Q92109 283 32 -
IRDVTDSLIEH CP11_CANFA 282 32 -
IRDITDSLIDH CP11_MICTO 279 32 -
VRDITGALFKH CP12_HUMAN 280 32 -
IRDVTDSLIEQ CP15_CHICK 287 32 -
IRDVTDSLIEQ CP15_CHICK 287 32 -
IRDITDSLIDH CP11_OPSTA 283 32 -
IQDITGALFKH CP12_RABIT 279 32 -
IQDITGALFKH CP12_RAT 279 32 -
IQDITSALFKH CP12_MOUSE 279 32 -
VQDITGALLKH CP12_CANFA 275 32 -
VQDIASALFKH CP12_CAVPO 280 32 -
IQDITGALFKH CP12_MESAU 279 32 -
IRDVTDSLIGH CP14_CHICK 289 32 -

Motif 5 width=11
Element Seqn Id St Int Rpt
ALSWSVMYLVA O42430 330 36 -
ALSWSVMYLVA O42231 330 36 -
ALSWSVMYLVA CP11_PLAFE 330 36 -
ALSWSVMYLVA CP11_PLEPL 330 36 -
ALSWSVMYLVA CP11_LIZSA 330 36 -
AISWSLMYLVT CP11_RAT 329 36 -
ALSWSVMYLVA CP11_SPAAU 330 36 -
AISWSLMYLVT CP11_MACFA 325 36 -
AISWSLMYLVM CP11_HUMAN 325 36 -
ALSWSVMYLVA CP11_STECH 330 36 -
AISWSLMYLVT CP11_MOUSE 329 36 -
ALSWSVMYLVA Q92039 330 36 -
ALSWAVVYLVA Q92110 330 36 -
AISWSLLYLVT CP11_SHEEP 332 36 -
AISWSLMYLVT CP11_MESAU 329 36 -
AISWSLMYLVT CP11_RABIT 329 36 -
AISWSLLYLVM CP11_CAVPO 321 36 -
ALSWAVVYLVA Q92109 330 36 -
AISWSLLYLVT CP11_CANFA 329 36 -
ALSWSVMYLVA CP11_MICTO 326 36 -
AISWSLMYLVT CP12_HUMAN 325 34 -
ALSWSLMYLVT CP15_CHICK 334 36 -
ALSWSLMYLVT CP15_CHICK 334 36 -
GLSWSVMYLVA CP11_OPSTA 330 36 -
ALSWSLMYLVT CP12_RABIT 324 34 -
AIFWSILLLVT CP12_RAT 323 33 -
AITWSILLLVT CP12_MOUSE 323 33 -
AISWSLMYLVA CP12_CANFA 320 34 -
AISWSLLYLVT CP12_CAVPO 325 34 -
AITLSILLLVT CP12_MESAU 323 33 -
ALSWCMMYAAL CP14_CHICK 336 36 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
LVAMTTVCLVYLI O42430 18 18 -
LVALVTVCLVYLI O42231 18 18 -
LVAMTTMCLVYLI CP11_PLAFE 18 18 -
LVAMTTMCLVYLI CP11_PLEPL 18 18 -
LVAVVTVCLVYLI CP11_LIZSA 18 18 -
LLAVTTFCLGFWV CP11_RAT 17 17 -
LVAIITMCLVYMI CP11_SPAAU 18 18 -
LVALTTVCLVYLI P79716 18 18 -
LVALTTVCLVYLI Q9PT96 18 18 -
LLASLIFCLVFWV CP11_MACFA 13 13 -
LLASVIFCLVFWV CP11_HUMAN 13 13 -
LVAMITMCLAYLI CP11_STECH 18 18 -
LLAVTVFCLGFWV CP11_MOUSE 17 17 -
LVAMITMCLAYLI CP11_PAGMA 18 18 -
LVAMVTLCLVYMI Q9PRH3 18 18 -
LVALTAVCLVYLI Q92039 18 18 -
LVAIVTLCLVYML Q92110 18 18 -
LLASAVFCLVFWV CP11_SHEEP 20 20 -
LLAITVFCLGFWV CP11_MESAU 17 17 -
LLASAVFCLVFWV CP11_RABIT 17 17 -
LLTATIFCLVLWV CP11_CAVPO 9 9 -
LLASAIFCLVFWV O77809 15 15 -
LVAMVTLCLVYMI Q92109 18 18 -
LIALVTVCLVYLT Q9YI64 18 18 -
LLASTVFCLVLWV CP11_CANFA 17 17 -
LVAMITVCMIYML CP11_MICTO 18 18 -
LLAMATVCIVYLL Q9PTY6 18 18 -
LLAMATVCIVYLL Q9PTY7 18 18 -
LLTSTVFCLVFWV O77810 15 15 -
LLASAIFCLVFWV CP12_HUMAN 15 15 -
LLASAIFCLVFWV Q9UK49 15 15 -
LLASAIFCLVFWV Q9BXX7 15 15 -
LVAAATFCLLLLL CP15_CHICK 22 22 -
LVAAATFCLLLLL CP15_CHICK 22 22 -
LVALITICVVYLI CP11_OPSTA 18 18 -
LLVSAVFCLVFWA CP12_RABIT 14 14 -
LLATAIFCLVFWV CP12_RAT 14 14 -
LVAVVTVCVVYLL Q9PTY4 18 18 -
LLATAIFCLVFWM CP12_MOUSE 14 14 -
LLASTIFCLILWV CP12_CANFA 10 10 -
LLTATIFYLVLWV CP12_CAVPO 15 15 -
VLATAIFCIVFWV CP12_MESAU 14 14 -
LLVSTVFAIVFLV Q9YI89 21 21 -
LVAAATFCLLLLL CP14_CHICK 24 24 -

Motif 2 width=10
Element Seqn Id St Int Rpt
PDLYSFRFIN O42430 112 81 -
PDLYSFRFIS O42231 112 81 -
PDLYSFRFIN CP11_PLAFE 112 81 -
PDLYSFRFIN CP11_PLEPL 112 81 -
PDLYSFRFIS CP11_LIZSA 112 81 -
PDLYSFTLIA CP11_RAT 111 81 -
PDLYSFRFIN CP11_SPAAU 112 81 -
PDLYSFRFIN P79716 112 81 -
PDLYSFRFIN Q9PT96 112 81 -
PNLYSFTLIS CP11_MACFA 107 81 -
PDLYTFTLIS CP11_HUMAN 107 81 -
PDLYSFRFIN CP11_STECH 112 81 -
PDLYSFTLIT CP11_MOUSE 111 81 -
PDLYSFKFIN CP11_PAGMA 112 81 -
PDLYSFKFIN Q9PRH3 112 81 -
PDLYSFTFIN Q92039 112 81 -
PDLYSFKFIN Q92110 112 81 -
PDLYSFTLVS CP11_SHEEP 114 81 -
PDFYSFTLIT CP11_MESAU 111 81 -
PDLYSFSFVT CP11_RABIT 111 81 -
PDLYSFTFIS CP11_CAVPO 103 81 -
PDLYSFTFIT O77809 109 81 -
SDLYSFKFIN Q92109 112 81 -
PDLYSFRFIN Q9YI64 112 81 -
PDLYSFSLVT CP11_CANFA 111 81 -
PDLYSFQFIN CP11_MICTO 109 78 -
PDLYSFQFIN Q9PTY6 112 81 -
PDLYSFQFIN Q9PTY7 112 81 -
PDLYSFTLIT O77810 109 81 -
PDLYTSTLIT CP12_HUMAN 109 81 -
PDLYTSTLIT Q9UK49 109 81 -
PDLYTSTLIT Q9BXX7 109 81 -
PDLYSFRHIT CP15_CHICK 116 81 -
PDLYSFRHIT CP15_CHICK 116 81 -
PDLYTFQFIS CP11_OPSTA 112 81 -
PDLYSSSFIT CP12_RABIT 108 81 -
PDLYSFTLIT CP12_RAT 108 81 -
PDLHSFQYIS Q9PTY4 112 81 -
PDLYSFTLIT CP12_MOUSE 108 81 -
PDLYSLSLIT CP12_CANFA 104 81 -
PDLYSSTFIS CP12_CAVPO 109 81 -
PDLYSFTLIT CP12_MESAU 108 81 -
PDLFTFRLVG Q9YI89 115 81 -
PDLPSWQYVS CP14_CHICK 118 81 -

Motif 3 width=11
Element Seqn Id St Int Rpt
DFIPILQYLPS O42430 240 118 -
DFIPILQYLPN O42231 240 118 -
DFIPILQYLPS CP11_PLAFE 240 118 -
DFIPILQYLPS CP11_PLEPL 240 118 -
DFIPILQYLPN CP11_LIZSA 240 118 -
DFIPILRYLPN CP11_RAT 239 118 -
DFIPILQYLPS CP11_SPAAU 240 118 -
DFIPVLQFLPS P79716 241 119 -
DFIPVLQFLPS Q9PT96 240 118 -
DFIPILRYLPN CP11_MACFA 235 118 -
DFIPILRYLPN CP11_HUMAN 235 118 -
DFIPILQYLPS CP11_STECH 240 118 -
DFIPVLRYLPN CP11_MOUSE 239 118 -
DFIPILQYLPS CP11_PAGMA 237 115 -
DFIPILRYLPN Q9PRH3 240 118 -
DFINILRFLPS Q92039 240 118 -
DFIPILRYLPN Q92110 240 118 -
DFIPVLRYLPN CP11_SHEEP 242 118 -
DFIPILRYLPN CP11_MESAU 239 118 -
DFFLILRYLPN CP11_RABIT 239 118 -
DFIPILRYLPS CP11_CAVPO 231 118 -
DFFPILRYLPN O77809 237 118 -
DFIPILRYLPN Q92109 240 118 -
DFIPALQFLPN Q9YI64 240 118 -
DFFPILRYLPN CP11_CANFA 239 118 -
DFIPLLRFLPN CP11_MICTO 236 117 -
DFIPFLRFLPS Q9PTY6 240 118 -
DFIPFLRFLPS Q9PTY7 240 118 -
DFFPILRYLPN O77810 237 118 -
DFFPILRYLPN CP12_HUMAN 237 118 -
DFFPILRYLPN Q9UK49 237 118 -
DFFPILRYLPN Q9BXX7 237 118 -
DFIPLLRYLPS CP15_CHICK 244 118 -
DFIPLLRYLPS CP15_CHICK 244 118 -
DFIPVLRFLPS CP11_OPSTA 240 118 -
DFFPILRYLPN CP12_RABIT 236 118 -
DFFPVLRYLPN CP12_RAT 236 118 -
DFIPFLRFLPS Q9PTY4 240 118 -
DFFPVLRYLPN CP12_MOUSE 236 118 -
DFFPILQYMPN CP12_CANFA 232 118 -
DFFPILRYLPN CP12_CAVPO 237 118 -
DFFPILRYLPN CP12_MESAU 236 118 -
DFIPILQYLPS Q9YI89 243 118 -
DFIPLLRYLPN CP14_CHICK 246 118 -

Motif 4 width=11
Element Seqn Id St Int Rpt
IRDITDSLIDH O42430 283 32 -
IRDITDSLIDH O42231 283 32 -
IRDITDSLIDH CP11_PLAFE 283 32 -
IRDITDSLIDH CP11_PLEPL 283 32 -
IRDITDSLIDH CP11_LIZSA 283 32 -
IRDITDSLIEH CP11_RAT 282 32 -
IRDITDSLIDH CP11_SPAAU 283 32 -
IRDITDSLIDH P79716 284 32 -
IRDITDSLIDH Q9PT96 283 32 -
IRDITDSLIEH CP11_MACFA 278 32 -
IRDITDSLIEH CP11_HUMAN 278 32 -
IRDITDSLIDH CP11_STECH 283 32 -
IRDITDSLIEH CP11_MOUSE 282 32 -
IRDITDSLIDH CP11_PAGMA 280 32 -
IRDITDSLIDH Q9PRH3 283 32 -
IRDITDSLIDH Q92039 283 32 -
IRDITDSLIDH Q92110 283 32 -
IRDITDSLIEH CP11_SHEEP 285 32 -
IRDITDSLIEH CP11_MESAU 282 32 -
IRDITDSLIKH CP11_RABIT 282 32 -
IRDITDSLIEH CP11_CAVPO 274 32 -
VQDITGALFKH O77809 280 32 -
IRDITDSLIDH Q92109 283 32 -
IRDITDSLIDH Q9YI64 283 32 -
IRDVTDSLIEH CP11_CANFA 282 32 -
IRDITDSLIDH CP11_MICTO 279 32 -
IRDITDSLIDH Q9PTY6 283 32 -
IRDITDSLIDH Q9PTY7 283 32 -
VQDITGALFKH O77810 280 32 -
VRDITGALFKH CP12_HUMAN 280 32 -
VRDITGALFKH Q9UK49 280 32 -
VRDITGALFKH Q9BXX7 280 32 -
IRDVTDSLIEQ CP15_CHICK 287 32 -
IRDVTDSLIEQ CP15_CHICK 287 32 -
IRDITDSLIDH CP11_OPSTA 283 32 -
IQDITGALFKH CP12_RABIT 279 32 -
IQDITGALFKH CP12_RAT 279 32 -
IRDITDSLIDH Q9PTY4 283 32 -
IQDITSALFKH CP12_MOUSE 279 32 -
VQDITGALLKH CP12_CANFA 275 32 -
VQDIASALFKH CP12_CAVPO 280 32 -
IQDITGALFKH CP12_MESAU 279 32 -
IRDITDSLIQH Q9YI89 286 32 -
IRDVTDSLIGH CP14_CHICK 289 32 -

Motif 5 width=11
Element Seqn Id St Int Rpt
ALSWSVMYLVA O42430 330 36 -
ALSWSVMYLVA O42231 330 36 -
ALSWSVMYLVA CP11_PLAFE 330 36 -
ALSWSVMYLVA CP11_PLEPL 330 36 -
ALSWSVMYLVA CP11_LIZSA 330 36 -
AISWSLMYLVT CP11_RAT 329 36 -
ALSWSVMYLVA CP11_SPAAU 330 36 -
ALSWSVMYLVA P79716 331 36 -
ALSWSVMYLVA Q9PT96 330 36 -
AISWSLMYLVT CP11_MACFA 325 36 -
AISWSLMYLVM CP11_HUMAN 325 36 -
ALSWSVMYLVA CP11_STECH 330 36 -
AISWSLMYLVT CP11_MOUSE 329 36 -
ALSWSVMYLVA CP11_PAGMA 324 33 -
ALSWAVVYLVA Q9PRH3 330 36 -
ALSWSVMYLVA Q92039 330 36 -
ALSWAVVYLVA Q92110 330 36 -
AISWSLLYLVT CP11_SHEEP 332 36 -
AISWSLMYLVT CP11_MESAU 329 36 -
AISWSLMYLVT CP11_RABIT 329 36 -
AISWSLLYLVM CP11_CAVPO 321 36 -
AISWSLMYLVT O77809 325 34 -
ALSWAVVYLVA Q92109 330 36 -
ALSWAVMYLVA Q9YI64 330 36 -
AISWSLLYLVT CP11_CANFA 329 36 -
ALSWSVMYLVA CP11_MICTO 326 36 -
ALSWAVVYLVA Q9PTY6 330 36 -
ALSWAVVYLVA Q9PTY7 330 36 -
AISWSLMYLVT O77810 325 34 -
AISWSLMYLVT CP12_HUMAN 325 34 -
AISWSLMYLVT Q9UK49 325 34 -
AISWSLMYLVT Q9BXX7 325 34 -
ALSWSLMYLVT CP15_CHICK 334 36 -
ALSWSLMYLVT CP15_CHICK 334 36 -
GLSWSVMYLVA CP11_OPSTA 330 36 -
ALSWSLMYLVT CP12_RABIT 324 34 -
AIFWSILLLVT CP12_RAT 323 33 -
FLSWAVMYLVT Q9PTY4 330 36 -
AITWSILLLVT CP12_MOUSE 323 33 -
AISWSLMYLVA CP12_CANFA 320 34 -
AISWSLLYLVT CP12_CAVPO 325 34 -
AITLSILLLVT CP12_MESAU 323 33 -
ALSWSLMYLVA Q9YI89 333 36 -
ALSWCMMYAAL CP14_CHICK 336 36 -