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PR01682

Identifier
FMRFAMIDEPEP  [View Relations]  [View Alignment]  
Accession
PR01682
No. of Motifs
6
Creation Date
28-MAR-2002
Title
FMRFamide-related peptide precursor signature
Database References
Literature References
1. PANULA, P., AARNISALO, A.A. AND WASOWICZ, K.
Neuropeptide FF, a mammalian neuropeptide with multiple functions.
PROG.NEUROBIOL. 48(4-5) 461-487 (1996).
 
2. KOTANI, M., MOLLEREAU, C., DETHEUX, M., LE POUL, E., BREZILLON, S.,
VAKILI, J., MAZARGUIL, H., VASSART, G., ZAJAC, J.M. AND PARMENTIER, M.
Functional characterization of a human receptor for neuropeptide FF and
related peptides.
BR.J.PHARMACOL. 133 138-144 (2001).

Documentation
Neuropeptide FF (together with neuropeptides AF and SF, which are derived
from the same precursor) belongs to a family of neuropeptides containing an 
RF-amide motif at their C-termini [1]. Neuropeptide FF is found at high
concentrations in the posterior pituitary, spinal cord, hypothalamus and 
medulla, and is believed to be involved in pain modulation, opioid tolerance,
cardiovascular regulation, memory and neuroendocrine regulation [1,2].
 
FMRFAMIDEPEP is a 6-element fingerprint that provides a signature for the
FMRFamide-related peptide precursor. The fingerprint was derived from an
initial alignment of 4 sequences: the motifs were drawn from conserved
sections spanning the full alignment length - motif 1 encodes the putative
signal peptide; motif 4 spans the region of the precursor that encodes
neuropeptides SF and FF; and motif 6 encodes neuropeptide AF. A single
iteration on SPTR40_18f was required to reach convergence, no further 
sequences being identified beyond the starting set.
Summary Information
4 codes involving  6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
6444444
5000000
4000000
3000000
2000000
123456
True Positives
NPFF_BOVIN    NPFF_HUMAN    NPFF_MOUSE    NPFF_RAT      
Sequence Titles
NPFF_BOVIN  FMRFamide-related peptides precursor [Contains: Neuropeptide SF (NPSF); Neuropeptide FF (NPFF); Neuropeptide AF (NPAF)] - Bos taurus (Bovine). 
NPFF_HUMAN FMRFamide-related peptides precursor [Contains: Neuropeptide SF (NPSF); Neuropeptide FF (NPFF); Neuropeptide AF (NPAF)] - Homo sapiens (Human).
NPFF_MOUSE FMRFamide-related peptides precursor [Contains: Neuropeptide SF (NPSF); Neuropeptide FF (NPFF); Neuropeptide AF-like (NPAF)] - Mus musculus (Mouse).
NPFF_RAT FMRFamide-related peptides precursor [Contains: Neuropeptide SF (NPSF); Neuropeptide FF (NPFF); Neuropeptide AF-like (NPAF)] - Rattus norvegicus (Rat).
Scan History
SPTR40_18f 1  120  NSINGLE    
Initial Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
MDSKWAAVLLLLLLL NPFF_RAT 1 1 -
MDSKWAALLLLLLLL NPFF_MOUSE 1 1 -
MDARQAAALLLVLLL NPFF_BOVIN 1 1 -
MDSRQAAALLVLLLL NPFF_HUMAN 1 1 -

Motif 2 width=15
Element Seqn Id St Int Rpt
GEDQVFAEEDKGPHP NPFF_RAT 28 12 -
GEDQVFAGEDKGPHP NPFF_MOUSE 28 12 -
GGDQIFMEEDSGAHP NPFF_BOVIN 30 14 -
QEDQLSAEEDSEPLP NPFF_HUMAN 28 12 -

Motif 3 width=17
Element Seqn Id St Int Rpt
QTPGSLMRVLLQAMERP NPFF_RAT 53 10 -
QTPGSLFRVLLQAMDTP NPFF_MOUSE 53 10 -
QTPRSLLRSLLQAMQRP NPFF_BOVIN 49 4 -
QTSGSLLHYLLQAMERP NPFF_HUMAN 47 4 -

Motif 4 width=17
Element Seqn Id St Int Rpt
PRRNPAFLFQPQRFGRN NPFF_RAT 69 -1 -
PRRSPAFLFQPQRFGRS NPFF_MOUSE 69 -1 -
PGRSPAFLFQPQRFGRN NPFF_BOVIN 65 -1 -
PGRSQAFLFQPQRFGRN NPFF_HUMAN 63 -1 -

Motif 5 width=17
Element Seqn Id St Int Rpt
NAWGPWSKEQLSPQARE NPFF_RAT 85 -1 -
SAWGSWSKEQLNPQARQ NPFF_MOUSE 85 -1 -
NTRGSWSNKRLSPRAGE NPFF_BOVIN 81 -1 -
NTQGSWRNEWLSPRAGE NPFF_HUMAN 79 -1 -

Motif 6 width=13
Element Seqn Id St Int Rpt
FWSLAAPQRFGKK NPFF_RAT 102 0 -
FWSLAAPQRFGKK NPFF_MOUSE 102 0 -
FWSLAAPQRFGKK NPFF_BOVIN 103 5 -
FWSLAAPQRFGKK NPFF_HUMAN 101 5 -
Final Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
MDSKWAAVLLLLLLL NPFF_RAT 1 1 -
MDSKWAALLLLLLLL NPFF_MOUSE 1 1 -
MDARQAAALLLVLLL NPFF_BOVIN 1 1 -
MDSRQAAALLVLLLL NPFF_HUMAN 1 1 -

Motif 2 width=15
Element Seqn Id St Int Rpt
GEDQVFAEEDKGPHP NPFF_RAT 28 12 -
GEDQVFAGEDKGPHP NPFF_MOUSE 28 12 -
GGDQIFMEEDSGAHP NPFF_BOVIN 30 14 -
QEDQLSAEEDSEPLP NPFF_HUMAN 28 12 -

Motif 3 width=17
Element Seqn Id St Int Rpt
QTPGSLMRVLLQAMERP NPFF_RAT 53 10 -
QTPGSLFRVLLQAMDTP NPFF_MOUSE 53 10 -
QTPRSLLRSLLQAMQRP NPFF_BOVIN 49 4 -
QTSGSLLHYLLQAMERP NPFF_HUMAN 47 4 -

Motif 4 width=17
Element Seqn Id St Int Rpt
PRRNPAFLFQPQRFGRN NPFF_RAT 69 -1 -
PRRSPAFLFQPQRFGRS NPFF_MOUSE 69 -1 -
PGRSPAFLFQPQRFGRN NPFF_BOVIN 65 -1 -
PGRSQAFLFQPQRFGRN NPFF_HUMAN 63 -1 -

Motif 5 width=17
Element Seqn Id St Int Rpt
NAWGPWSKEQLSPQARE NPFF_RAT 85 -1 -
SAWGSWSKEQLNPQARQ NPFF_MOUSE 85 -1 -
NTRGSWSNKRLSPRAGE NPFF_BOVIN 81 -1 -
NTQGSWRNEWLSPRAGE NPFF_HUMAN 79 -1 -

Motif 6 width=13
Element Seqn Id St Int Rpt
FWSLAAPQRFGKK NPFF_RAT 102 0 -
FWSLAAPQRFGKK NPFF_MOUSE 102 0 -
FWSLAAPQRFGKK NPFF_BOVIN 103 5 -
FWSLAAPQRFGKK NPFF_HUMAN 101 5 -