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PR01653

Identifier
TCTPROTEIN  [View Relations]  [View Alignment]  
Accession
PR01653
No. of Motifs
3
Creation Date
17-DEC-2001
Title
Translationally controlled tumour protein signature
Database References

PROSITE; PS01002 TCTP_1; PS01003 TCTP_2
PFAM; PF00838 TCTP
INTERPRO; IPR001983
PDB; 1H7Y
SCOP; 1H7Y
CATH; 1H7Y
Literature References
1. THIELE, H., BERGER, M., SKALWEIT, A. AND THIELE, B-J.
Expression of the gene and processed pseudogenes encoding the human and
rabbit translationally controlled tumour protein (TCTP).
EUR.J.BIOCHEM. 267 5473-5481 (2000).
 
2. THAW, P., BAXTER, N.J., HOUNSLOW, A.M., PRICE, C., WALTHO, J.P. AND
CRAVEN, C.J.
Structure of TCTP reveals unexpected relationship with guanine
nucleotide-free chaperones.
NAT.STRUCT.BIOL. 8(8) 701-704 (2001).

Documentation
Translationally controlled tumour protein (TCTP) is a well-conserved,
ubiquitously expressed protein, found in species throughout the eukaryotic
kingdom. Nevertheless, the function of the protein is poorly understood. It
was first identified as a histamine-releasing factor, acting in IgE +-
dependent allergic reactions. In addition, TCTP has been shown to bind to
tubulin in the cytoskeleton, has a high affinity for calcium, is the binding
target for the antimalarial compound artemisinin, and is induced in vitamin
D-dependent apoptosis. TCTP production is thought to be controlled at the
translational as well as the transcriptional level [1].
 
TCTPs do not share significant sequence similarity with any other class of
proteins. Recently, the structure of TCTP was determined and exhibited
significant structural similarity to the human protein Mss4, which is a
guanine nucleotide-free chaperone of the Rab protein [2].
 
TCTPROTEIN is a 3-element fingerprint that provides a signature for the
translationally controlled tumour proteins. The fingerprint was derived from
an initial alignment of 11 sequences: the motifs were drawn from conserved
regions spanning the N-terminal half of the alignment - motif 1 includes
beta-strands 1 and 2; motif 2 lies in the loop between beta-strands 5 and 6;
and motif 3 encompasses beta-strand 6, helix 1 and beta-strand 7. Two
iterations on SPTR40_18f were required to reach convergence, at which point
a true set comprising 28 sequences was identified.
Summary Information
28 codes involving  3 elements
0 codes involving 2 elements
Composite Feature Index
3282828
2000
123
True Positives
Q98SJ7        Q9DGK4        Q9HAU6        Q9M5G3        
Q9M5I8 Q9M9V9 Q9UP43 TCTP_ARATH
TCTP_BRUMA TCTP_CAEEL TCTP_CHICK TCTP_DROME
TCTP_FRAAN TCTP_HEVBR TCTP_HUMAN TCTP_HYDAT
TCTP_LUMRU TCTP_MEDSA TCTP_MOUSE TCTP_ORYSA
TCTP_PEA TCTP_PSEMZ TCTP_RABIT TCTP_SCHJA
TCTP_SCHPO TCTP_SOLTU TCTP_TOBAC TCTP_YEAST
Sequence Titles
Q98SJ7      TRANSLATIONALLY CONTROLLED TUMOR PROTEIN - Labeo rohita. 
Q9DGK4 TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN - Brachydanio rerio (Zebrafish) (Zebra danio).
Q9HAU6 APOPTOSIS INHIBITOR - Homo sapiens (Human).
Q9M5G3 HUMAN TUMOR PROTEIN-LIKE PROTEIN - Hordeum vulgare (Barley).
Q9M5I8 TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED PROTEIN - Cucumis melo (Muskmelon).
Q9M9V9 PUTATIVE TRANSLATIONALLY CONTROLLED TUMOR PROTEIN - Arabidopsis thaliana (Mouse-ear cress).
Q9UP43 HDCMB21P - Homo sapiens (Human).
TCTP_ARATH Translationally controlled tumor protein homolog (TCTP) - Arabidopsis thaliana (Mouse-ear cress).
TCTP_BRUMA Translationally controlled tumor protein homolog (TCTP) (TPH-1) - Brugia malayi.
TCTP_CAEEL Translationally controlled tumor protein homolog (TCTP) - Caenorhabditis elegans.
TCTP_CHICK Translationally controlled tumor protein (TCTP) (p23) (pCHK23) - Gallus gallus (Chicken).
TCTP_DROME Translationally controlled tumor protein homolog (TCTP) - Drosophila melanogaster (Fruit fly).
TCTP_FRAAN Translationally controlled tumor protein homolog (TCTP) - Fragaria ananassa (Strawberry).
TCTP_HEVBR Translationally controlled tumor protein homolog (TCTP) - Hevea brasiliensis (Para rubber tree).
TCTP_HUMAN Translationally controlled tumor protein (TCTP) (p23) (Histamine- releasing factor) (HRF) - Homo sapiens (Human).
TCTP_HYDAT Translationally controlled tumor protein homolog (TCTP) - Hydra attenuata (Hydra) (Hydra vulgaris).
TCTP_LUMRU Translationally controlled tumor protein homolog (TCTP) - Lumbricus rubellus (Humus earthworm).
TCTP_MEDSA Translationally controlled tumor protein homolog (TCTP) - Medicago sativa (Alfalfa).
TCTP_MOUSE Translationally controlled tumor protein (TCTP) (p23) (21 kDa polypeptide) (p21) (Lens epithelial protein) - Mus musculus (Mouse), and Rattus norvegicus (Rat).
TCTP_ORYSA Translationally controlled tumor protein homolog (TCTP) - Oryza sativa (Rice).
TCTP_PEA Translationally controlled tumor protein homolog (TCTP) (23 kDa callus protein) (P23) - Pisum sativum (Garden pea).
TCTP_PSEMZ Translationally controlled tumor protein homolog (TCTP) - Pseudotsuga menziesii (Douglas-fir).
TCTP_RABIT Translationally controlled tumor protein (TCTP) - Oryctolagus cuniculus (Rabbit).
TCTP_SCHJA Translationally controlled tumor protein homolog (TCTP) - Schistosoma japonicum (Blood fluke).
TCTP_SCHPO Translationally controlled tumor protein homolog (TCTP) - Schizosaccharomyces pombe (Fission yeast).
TCTP_SOLTU Translationally controlled tumor protein homolog (TCTP) (P23) - Solanum tuberosum (Potato).
TCTP_TOBAC Translationally controlled tumor protein homolog (TCTP) - Nicotiana tabacum (Common tobacco).
TCTP_YEAST Translationally controlled tumor protein homolog (TCTP) - Saccharomyces cerevisiae (Baker's yeast).
Scan History
SPTR40_18f 2  300  NSINGLE    
Initial Motifs
Motif 1  width=21
Element Seqn Id St Int Rpt
MLVYQDLLTGDELLSDSFPYT TCTP_SOLTU 1 1 -
MLVYQDLLTGDELLSDSFPYR TCTP_ORYSA 1 1 -
MLVYQDILTGDELLSDSFPYK Q9M9V9 1 1 -
MIIYRDLISHDELFSDIYKIR TCTP_MOUSE 1 1 -
MIIYRDLISHDEMFSDIYKIR Q9UP43 1 1 -
MIIYRDCISQDEMFSDIYKIR TCTP_CHICK 1 1 -
MIIYKDIFSNDELLSDAYDAK TCTP_YEAST 1 1 -
MLIYKDIFTDDELSSDSFPMK TCTP_CAEEL 1 1 -
MLLYKDVISGDELVSDAYDLK TCTP_SCHPO 1 1 -
MIIFQDLISHNEMFSDIYKIW Q9HAU6 1 1 -
MYIYNCIFTGKEVFSDAYPHK TCTP_HYDAT 1 1 -

Motif 2 width=12
Element Seqn Id St Int Rpt
GANPSAEGGGED TCTP_SOLTU 46 24 -
GANPSAEGGGDD TCTP_ORYSA 46 24 -
GKNPSGEEGGED Q9M9V9 33 11 -
GGNASAEGPEGE TCTP_MOUSE 49 27 -
GGNASAEGPEGE Q9UP43 49 27 -
GGNASAEGPEGE TCTP_CHICK 49 27 -
GANPSAEGGDDD TCTP_YEAST 45 23 -
GSNPSAEEGAED TCTP_CAEEL 46 24 -
GANPSAEDAEEN TCTP_SCHPO 46 24 -
GRNSSSESTEDE Q9HAU6 49 27 -
GGNKSAEGEDDE TCTP_HYDAT 49 27 -

Motif 3 width=20
Element Seqn Id St Int Rpt
VDDQAVKVVDIVDTFRLQEQ TCTP_SOLTU 60 2 -
VDDQAVKVVDIVDTFRLQEQ TCTP_ORYSA 60 2 -
VDDQAVKVVDIIDTFRLQEQ Q9M9V9 47 2 -
TESTVVTGVDIVMNHHLQET TCTP_MOUSE 62 1 -
TESTVITGVDIVMNHHLQET Q9UP43 62 1 -
TEATVITGVDIVINHHLQET TCTP_CHICK 62 1 -
VEEGAEMVNNVVHSFRLQQT TCTP_YEAST 57 0 -
SDEHVERGIDIVLNHKLVEM TCTP_CAEEL 60 2 -
AEEGTETVNNLVYSFRLSPT TCTP_SCHPO 58 0 -
TESTIITSVDIVTNHHLQES Q9HAU6 62 1 -
STEYKPVVNTLLRAFRLEEP TCTP_HYDAT 64 3 -
Final Motifs
Motif 1  width=21
Element Seqn Id St Int Rpt
MLVYQDLLTGDELLSDSFPYK TCTP_HEVBR 1 1 -
MLVYQDLVSGDELLSDSFPYK Q9M5I8 1 1 -
MLVYQDLLTGDELLSDSFPYT TCTP_SOLTU 1 1 -
MLVYQDLLTGDELLSDSYPYK TCTP_PEA 1 1 -
MLVYQDKLSGDELLSDSFPYR Q9M5G3 1 1 -
MLVYQDLLTGDELLSDSFPYR TCTP_ORYSA 1 1 -
MLVYQDLLTGDELLSDSYPYK TCTP_MEDSA 1 1 -
MLVYQDLLSGDELLSDSFPYK TCTP_FRAAN 1 1 -
MIVYQDLLSGDELLSDSFPYK TCTP_PSEMZ 1 1 -
MLVYQDLLTGDELLSDSFPYK TCTP_ARATH 1 1 -
MLVYQDLLSGDELPSDSFSYT TCTP_TOBAC 1 1 -
MLVYQDILTGDELLSDSFPYK Q9M9V9 1 1 -
MIIYRDLISHDELFSDIYKIR TCTP_MOUSE 1 1 -
MIIYRDLISHDEMFSDIYKIR Q9UP43 1 1 -
MIIYRDLISHDEMFSDIYKIR TCTP_RABIT 1 1 -
MIIYRDLISHDEMFSDIYKIR TCTP_HUMAN 1 1 -
MIIYKDIITGDEMFSDIYKIK Q9DGK4 1 1 -
MIIYKDIITGDEMFSDIYKIK Q98SJ7 1 1 -
MIIYRDCISQDEMFSDIYKIR TCTP_CHICK 1 1 -
MLIFKDAFTDDELASDSFPMK TCTP_BRUMA 1 1 -
MIIYKDIFSNDELLSDAYDAK TCTP_YEAST 1 1 -
MLIYKDIFTDDELSSDSFPMK TCTP_CAEEL 1 1 -
MKIYKDIITGDEMFADTYKMK TCTP_DROME 1 1 -
MIIFKDVFPGVELFSDSFPVS TCTP_LUMRU 1 1 -
MLLYKDVISGDELVSDAYDLK TCTP_SCHPO 1 1 -
MIIFQDLISHNEMFSDIYKIW Q9HAU6 1 1 -
MRVFKDAISGDEMFSDSHSPQ TCTP_SCHJA 1 1 -
MYIYNCIFTGKEVFSDAYPHK TCTP_HYDAT 1 1 -

Motif 2 width=12
Element Seqn Id St Int Rpt
GANPSAEGADED TCTP_HEVBR 46 24 -
GANPSAEGGGED Q9M5I8 46 24 -
GANPSAEGGGED TCTP_SOLTU 46 24 -
GANPSAEGGEDE TCTP_PEA 46 24 -
GANPSAEGGGED Q9M5G3 46 24 -
GANPSAEGGGDD TCTP_ORYSA 46 24 -
GANASAEGGEDE TCTP_MEDSA 46 24 -
GANPSAEGADAD TCTP_FRAAN 46 24 -
GANPSAEGGDEE TCTP_PSEMZ 46 24 -
GANPSAEEGGED TCTP_ARATH 46 24 -
GANPSAEGADED TCTP_TOBAC 46 24 -
GKNPSGEEGGED Q9M9V9 33 11 -
GGNASAEGPEGE TCTP_MOUSE 49 27 -
GGNASAEGPEGE Q9UP43 49 27 -
GGNASAEGPEGE TCTP_RABIT 49 27 -
GGNASAEGPEGE TCTP_HUMAN 49 27 -
GGNASAEVADEG Q9DGK4 49 27 -
GGNASAEVQDEG Q98SJ7 49 27 -
GGNASAEGPEGE TCTP_CHICK 49 27 -
GANPSAEGEDGD TCTP_BRUMA 46 24 -
GANPSAEGGDDD TCTP_YEAST 45 23 -
GSNPSAEEGAED TCTP_CAEEL 46 24 -
GANASAEEADEG TCTP_DROME 46 24 -
GGNASAEGGEEG TCTP_LUMRU 47 25 -
GANPSAEDAEEN TCTP_SCHPO 46 24 -
GRNSSSESTEDE Q9HAU6 49 27 -
AANPSGEEGQEE TCTP_SCHJA 47 25 -
GGNKSAEGEDDE TCTP_HYDAT 49 27 -

Motif 3 width=20
Element Seqn Id St Int Rpt
VDDQAVKVVDIVDTFRLQEQ TCTP_HEVBR 60 2 -
VDDQAVKVVDIVDTFRLQEQ Q9M5I8 60 2 -
VDDQAVKVVDIVDTFRLQEQ TCTP_SOLTU 60 2 -
VDDTAVKVVDIVDVFRLQEQ TCTP_PEA 59 1 -
VDDQAVKVVDIVDTFRLQEQ Q9M5G3 60 2 -
VDDQAVKVVDIVDTFRLQEQ TCTP_ORYSA 60 2 -
VDDTAVKVVDIVDVFRLQEQ TCTP_MEDSA 59 1 -
VDDQTVKVVDIVDTFRLQEQ TCTP_FRAAN 62 4 -
VKIRLVKVVDIVDTFRLQEQ TCTP_PSEMZ 59 1 -
VDDSTQKVVDIVDTFRLQEQ TCTP_ARATH 60 2 -
VDDQAIKVVDIVDTFRLQEQ TCTP_TOBAC 60 2 -
VDDQAVKVVDIIDTFRLQEQ Q9M9V9 47 2 -
TESTVVTGVDIVMNHHLQET TCTP_MOUSE 62 1 -
TESTVITGVDIVMNHHLQET Q9UP43 62 1 -
TESTVITGVDIVMNHHLQET TCTP_RABIT 62 1 -
TESTVITGVDIVMNHHLQET TCTP_HUMAN 62 1 -
CDSTSVSGVDIVLNHKLQET Q9DGK4 61 0 -
CESTTVSGVDIVLNHKLQET Q98SJ7 61 0 -
TEATVITGVDIVINHHLQET TCTP_CHICK 62 1 -
SEECVERGIDFVLNHRLQEM TCTP_BRUMA 60 2 -
VEEGAEMVNNVVHSFRLQQT TCTP_YEAST 57 0 -
SDEHVERGIDIVLNHKLVEM TCTP_CAEEL 60 2 -
TDITSESGVDVVLNHRLTEC TCTP_DROME 58 0 -
TDAASKQGVDIVMNSRLVEY TCTP_LUMRU 59 0 -
AEEGTETVNNLVYSFRLSPT TCTP_SCHPO 58 0 -
TESTIITSVDIVTNHHLQES Q9HAU6 62 1 -
VSDSTERVIDLVHASRLVST TCTP_SCHJA 59 0 -
STEYKPVVNTLLRAFRLEEP TCTP_HYDAT 64 3 -