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PR01573

Identifier
SUPERTUBBY  [View Relations]  [View Alignment]  
Accession
PR01573
No. of Motifs
7
Creation Date
19-AUG-2001
Title
Tubby superfamily signature
Database References
PRINTS; PR01574 TUBBYPROTEIN
PFAM; PF01167 Tub
INTERPRO; IPR000007
PDB; 1C8Z
SCOP; 1C8Z
CATH; 1C8Z
MIM; 602280; 600132; 601197; 602309
Literature References
1. KLEYN, P.W., FAN, W., KOVATS, S.G., LEE, J.L., PULIDO, J.C., WU, Y., 
BERKEMEIER, L.R., MISUMI, D.J., HOLMGREN, L., CHARLAT, O., WOOLF, E.A., 
TAYBER, O., BRODY, T., SHU, P., HAWKINS, F., KENNEDY, B., BALDINI, L., 
EBELING, C., ALPERIN, G.D., DEEDS, J., LAKEY, N.D., CULPEPPER, J., CHEN, 
H., GLUECKSMANN-KUIS, M.A., CARLSON, G.A., DUYK, G.M. AND MOORE, K.J. 
Identification and characterization of the mouse obesity gene tubby: a 
member of a novel gene family. 
CELL 85 281-290 (1996). 
 
2. NOBEN-TRAUTH, K., NAGGERT, J.K., NORTH, M.A. AND NISHINA, P.M.
A candidate gene for the mouse mutation tubby.
NATURE 380 534-538 (1996). 
 
3. BOGGON, T.J., SHAN, W.S., SANTAGATA, S., MYERS, S.C. AND SHAPIRO, L. 
Implication of tubby proteins as transcription factors by structure- based 
functional analysis. 
SCIENCE 286 2119-2125 (1999).  
 
4. NORTH, M.A., NAGGERT, J.K., YAN, Y., NOBEN-TRAUTH, K. AND NISHINA, P.M. 
Molecular characterization of TUB, TULP1, and TULP2, members of the novel 
tubby gene family and their possible relation to ocular diseases. 
PROC.NATL.ACAD.SCI.U.S.A. 94 3128-3133 (1997). 
 
5. NISHINA, P.M., NORTH, M.A., IKEDA, A., YAN, Y. AND NAGGERT, J.K. 
Molecular characterization of a novel tubby gene family member, TULP3, in 
mouse and humans. 
GENOMICS 54 215-220 (1998).

Documentation
A mutation in the mouse tub gene causes maturity-onset obesity, insulin 
resistance and sensory deficits [1,2]. By contrast with the rapid juvenile-
onset weight gain seen in diabetes (db) and obese (ob) mice, obesity in
tubby mice develops gradually, and strongly resembles the late-onset obesity
observed in the human population [2]. Excessive deposition of adipose tissue
culminates in a two-fold increase of body weight. Tubby mice also suffer
retinal degeneration and neurosensory hearing loss [2]. The tripartite
character of the tubby phenotype is highly similar to human obesity
syndromes, such as Alstrom and Bardet-Biedl [2]. Although these phenotypes
indicate a vital role for tubby proteins, no biochemical function has yet
been ascribed to any family member [3], although it has been suggested that
the phenotypic features of tubby mice may be the result of cellular 
apoptosis triggered by expression of the mutuated tub gene [2].
 
Tubby-like proteins (TULPs) are found in a wide range of multicellular
organisms [2]: for example, human TULP1 [4], which is involved in retinis
pigmentosa 14 (RP14); human TULP2 [4]; mammalian TULP3 [5]; mouse protein
p4-6, whose function is unknown; Caenorhabditis elegans hypothetical protein
F10B5.4; and a variety of other proteins from plants and Drosophila.
 
Mammalian tub is a hydrophilic protein of ~500 residues. The N-terminal
portion of the protein is conserved neither in length nor sequence, but the 
C-terminal 250 residues are highly conserved. The C-terminal extremity
contains a cysteine residue that might play an important role in the normal
functioning of these proteins.
 
The crystal structure of the C-terminal core domain from mouse tubby has
been determined to 1.9A resolution [3], revealing an alpha-beta protein with
a barrel architecture. Structural analyses suggest that TULPs constitute a
unique family of bipartite transcription factors [3]. 
 
SUPERTUBBY is a 7-element fingerprint that provides a signature for the
tubby-like protein family. The fingerprint was derived from an initial
alignment of 7 sequences: the motifs were drawn from conserved regions
spanning the C-terminal half of the alignment - motif 1 spans the C-terminus
of beta strand 4 and helix 2; motif 2 encompasses strands 5 and 6 and helix
3; motif 3 spans strands 7 and 8; motif 4 spans the C-terminus of strand 9 
and strands 10 and 11; motif 5 encompasses strands 12 and 13; motif 6 spans
strands 14 and 15; and motif 7, which includes the C-terminal cysteine
residue, encodes helix 6. Five iterations on SPTR39.22_17.3f were required
to reach convergence, at which point a true set comprising 22 sequences was
identified. Several partial matches were also found, all of which are tubby-
like proteins that fail to make significant matches with one or more motifs.
Summary Information
  22 codes involving  7 elements
2 codes involving 6 elements
0 codes involving 5 elements
2 codes involving 4 elements
3 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
722222222222222
61222221
50000000
40202220
30002331
20000101
1234567
True Positives
O82257        P46_MOUSE     Q9C6B4        Q9FRH7        
Q9M3H9 Q9MAG9 Q9SQU1 Q9ST78
Q9SXI3 Q9UB22 Q9W2L5 Q9XIF9
Q9YH17 Q9Z273 Q9ZP59 TUB_HUMAN
TUB_MOUSE TUB_RAT TUL1_HUMAN TUL3_HUMAN
TUL3_MOUSE YQQ4_CAEEL
True Positive Partials
Codes involving 6 elements
Q9ZPW1 TUL2_HUMAN
Codes involving 4 elements
Q9JIL5 Q9NRJ4
Codes involving 3 elements
Q9BL53 Q9N995 Q9VB18
Codes involving 2 elements
Q9S9M8
Sequence Titles
O82257      TUBBY-LIKE PROTEIN - Arabidopsis thaliana (Mouse-ear cress). 
P46_MOUSE P4-6 PROTEIN - Mus musculus (Mouse).
Q9C6B4 HYPOTHETICAL 43.3 KDA PROTEIN - Arabidopsis thaliana (Mouse-ear cress).
Q9FRH7 HYPOTHETICAL 50.0 KDA PROTEIN - Arabidopsis thaliana (Mouse-ear cress).
Q9M3H9 TUBBY-LIKE PROTEIN - Cicer arietinum (Chickpea) (Garbanzo).
Q9MAG9 F12M16.22 - Arabidopsis thaliana (Mouse-ear cress).
Q9SQU1 F24P17.15 PROTEIN - Arabidopsis thaliana (Mouse-ear cress).
Q9ST78 CAA303719.1 PROTEIN - Oryza sativa (Rice).
Q9SXI3 TUBBY-LIKE PROTEIN - Lemna paucicostata.
Q9UB22 TUBBY HOMOLOG - Caenorhabditis elegans.
Q9W2L5 CG9398 PROTEIN - Drosophila melanogaster (Fruit fly).
Q9XIF9 T10P12.9 PROTEIN - Arabidopsis thaliana (Mouse-ear cress).
Q9YH17 TUBBY-LIKE PROTEIN - Gallus gallus (Chicken).
Q9Z273 TUBBY LIKE PROTEIN 1 - Mus musculus (Mouse).
Q9ZP59 F22K20.1 PROTEIN (TUB FAMILY PROTEIN, PUTATIVE) - Arabidopsis thaliana (Mouse-ear cress).
TUB_HUMAN TUBBY PROTEIN HOMOLOG - Homo sapiens (Human).
TUB_MOUSE TUBBY PROTEIN - Mus musculus (Mouse).
TUB_RAT TUBBY PROTEIN HOMOLOG - Rattus norvegicus (Rat).
TUL1_HUMAN TUBBY RELATED PROTEIN 1 (TUBBY-LIKE PROTEIN 1) - Homo sapiens (Human).
TUL3_HUMAN TUBBY RELATED PROTEIN 3 (TUBBY-LIKE PROTEIN 3) - Homo sapiens (Human).
TUL3_MOUSE TUBBY RELATED PROTEIN 3 (TUBBY-LIKE PROTEIN 3) - Mus musculus (Mouse).
YQQ4_CAEEL HYPOTHETICAL 46.2 KDA PROTEIN F10B5.4 IN CHROMOSOME III - Caenorhabditis elegans.

Q9ZPW1 PUTATIVE TUBBY PROTEIN - Arabidopsis thaliana (Mouse-ear cress).
TUL2_HUMAN TUBBY RELATED PROTEIN 2 (TUBBY-LIKE PROTEIN 2) - Homo sapiens (Human).

Q9JIL5 TUBBY SUPER-FAMILY PROTEIN - Mus musculus (Mouse).
Q9NRJ4 TUBBY SUPER-FAMILY PROTEIN - Homo sapiens (Human).

Q9BL53 HYPOTHETICAL PROTEIN Y71G12A.3 - Caenorhabditis elegans.
Q9N995 POSSIBLE TUBBY-RELATED PROTEIN - Leishmania major.
Q9VB18 CG5586 PROTEIN - Drosophila melanogaster (Fruit fly).

Q9S9M8 T24D18.17 PROTEIN - Arabidopsis thaliana (Mouse-ear cress).
Scan History
SPTR39.22_17.3f 5  50   NSINGLE    
Initial Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
YLISVDPTDLSRGGDSY TUB_HUMAN 312 312 -
YLISVDPTDLSRGGDSY TUB_MOUSE 311 311 -
YLVSTDPTDLSREGESY TUL3_MOUSE 267 267 -
YLISIDPVDLSREGESY TUL3_HUMAN 249 249 -
YLISIDPTNLSRGGENF TUL1_HUMAN 350 350 -
YLLSTDPTNLSREGEGY YQQ4_CAEEL 213 213 -
YLISLDPKDMSRNGSNF P46_MOUSE 78 78 -

Motif 2 width=25
Element Seqn Id St Int Rpt
YIGKLRSNLMGTKFTVYDNGVNPQK TUB_HUMAN 328 -1 -
YIGKLRSNLMGTKFTVYDNGVNPQK TUB_MOUSE 327 -1 -
YIGKLRSNLMGTKFTVYDHGVNPVK TUL3_MOUSE 283 -1 -
YVGKLRSNLMGTKFTVYDRGICPMK TUL3_HUMAN 265 -1 -
FIGKLRSNLLGNRFTVFDNGQNPQR TUL1_HUMAN 366 -1 -
YCAKVRSNALGTQFTVYDSGQNPKK YQQ4_CAEEL 229 -1 -
FVGKVRSNVLGTKFTIFDNGVNPER P46_MOUSE 94 -1 -

Motif 3 width=28
Element Seqn Id St Int Rpt
RQELAAVCYETNVLGFKGPRKMSVIVPG TUB_HUMAN 364 11 -
RQELAAVCYETNVLGFKGPRKMSVIVPG TUB_MOUSE 363 11 -
RQELAAICYETNVLGFKGPRKMSVIIPG TUL3_MOUSE 318 10 -
RQELAAISYETNVLGFKGPRKMSVIIPG TUL3_HUMAN 300 10 -
RQELAAVIYETNVLGFRGPRRMTVIIPG TUL1_HUMAN 400 9 -
RQELAAVIYETNVLGFKGPRKMTIVMPG YQQ4_CAEEL 261 7 -
REELGVVCYETNVLGFRGPRKMTVILPG P46_MOUSE 129 10 -

Motif 4 width=18
Element Seqn Id St Int Rpt
LQNKTPVWNDDTQSYVLN TUB_HUMAN 425 33 -
LQNKTPVWNDDTQSYVLN TUB_MOUSE 424 33 -
LHNKAPVWNDDTQSYVLN TUL3_MOUSE 379 33 -
LHNKAPVWNSDTQSYVLN TUL3_HUMAN 361 33 -
LHNKPPVWNDDSGSYTLN TUL1_HUMAN 461 33 -
LSNKSPQWNDETQSYVLN YQQ4_CAEEL 327 38 -
LQNKAPSWSDESGAYVLN P46_MOUSE 190 33 -

Motif 5 width=17
Element Seqn Id St Int Rpt
FHGRVTQASVKNFQIIH TUB_HUMAN 443 0 -
FHGRVTQASVKNFQIIH TUB_MOUSE 442 0 -
FHGRVTQASVKNFQIVH TUL3_MOUSE 397 0 -
FRGRVTQASVKNFQLVH TUL3_HUMAN 379 0 -
FQGRVTQASVKNFQIVH TUL1_HUMAN 479 0 -
FHGRVTQASVKNFQIIH YQQ4_CAEEL 345 0 -
FHGRVSRASVKNFQIVH P46_MOUSE 208 0 -

Motif 6 width=20
Element Seqn Id St Int Rpt
PDYIVMQFGRVAEDVFTMDY TUB_HUMAN 463 3 -
PDYIVMQFGRVAEDVFTMDY TUB_MOUSE 462 3 -
PDYIVMQFGRVADDVFTLDY TUL3_MOUSE 417 3 -
PDYIVMQFGRVADDVFTLDY TUL3_HUMAN 399 3 -
PDYIVLQFGRVAEDAFTLDY TUL1_HUMAN 499 3 -
PEYIVMQFGRISDDEFTMDF YQQ4_CAEEL 365 3 -
PDHLVLQFGRVAPNIFTMDF P46_MOUSE 228 3 -

Motif 7 width=23
Element Seqn Id St Int Rpt
YPLCALQAFAIALSSFDSKLACE TUB_HUMAN 484 1 -
YPLCALQAFAIALSSFDSKLACE TUB_MOUSE 483 1 -
YPLCALQAFAIGLSSFDSKLACE TUL3_MOUSE 438 1 -
YPLCAVQAFAISLSSFDSKLACE TUL3_HUMAN 420 1 -
YPLCALQAFAIALSSFDGKLACE TUL1_HUMAN 520 1 -
YPLSAVQAFGIAMTSFHGKLACE YQQ4_CAEEL 386 1 -
YPLCPLQAFAICLSSFDGKLACE P46_MOUSE 249 1 -
Final Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
YLISVDPTDLSRGGDSY TUB_HUMAN 312 312 -
YLISVDPTDLSRGGDSY TUB_MOUSE 311 311 -
YLISVDPTDLSRGGDSY TUB_RAT 311 311 -
YLVSTDPTDLSREGESY TUL3_MOUSE 267 267 -
YLISIDPTDLSRGGENF Q9YH17 167 167 -
YLISIDPVDLSREGESY TUL3_HUMAN 249 249 -
YLISIDPTNLSRGGENF TUL1_HUMAN 350 350 -
YLISSDPTNLSRGGENF Q9Z273 351 351 -
YIISMDADNISRSSNSY Q9FRH7 175 175 -
YVISMHADTISRSSNTY Q9ZP59 173 173 -
YIISMDSKNISRSSSGY Q9ST78 172 172 -
YIISLNCDDVSRGSNTY O82257 169 169 -
YLLSTDPTNLSREGEGY Q9UB22 231 231 -
YLLSTDPTNLSREGEGY YQQ4_CAEEL 213 213 -
YIVSCDPTDLSRNADGF Q9W2L5 256 256 -
TSSPWNADDISRSSSTY Q9SXI3 177 177 -
FVVSLSGNDFSRSSSNY Q9C6B4 160 160 -
YLISLDPKDMSRNGSNF P46_MOUSE 78 78 -
IVISLAADDFSRASNNY Q9M3H9 168 168 -
YVISMDADNISRSSSTY Q9XIF9 157 157 -
YIISLRSDDISKRSNAY Q9SQU1 149 149 -
YIISLDADDFSQGSNAY Q9MAG9 326 326 -

Motif 2 width=25
Element Seqn Id St Int Rpt
YIGKLRSNLMGTKFTVYDNGVNPQK TUB_HUMAN 328 -1 -
YIGKLRSNLMGTKFTVYDNGVNPQK TUB_MOUSE 327 -1 -
YIGKLRSNLMGTKFTVYDNGVNPQK TUB_RAT 327 -1 -
YIGKLRSNLMGTKFTVYDHGVNPVK TUL3_MOUSE 283 -1 -
FIGKLRSNLMGTKFTVFDNGANPDR Q9YH17 183 -1 -
YVGKLRSNLMGTKFTVYDRGICPMK TUL3_HUMAN 265 -1 -
FIGKLRSNLLGNRFTVFDNGQNPQR TUL1_HUMAN 366 -1 -
FIGKLRSNLLGNRFTVFDNGQNPQR Q9Z273 367 -1 -
YLGKLRSNFLGTKFLVYDTQPPPNT Q9FRH7 191 -1 -
YIGKIRSNFLGTKFIIYDTQPAYNS Q9ZP59 189 -1 -
YIGKLRSNFLGTKFIIYDTQPPYNA Q9ST78 188 -1 -
YIGKLRSNFLGTKFTVYDAQPTNPG O82257 185 -1 -
YCAKVRSNALGTQFTVYDSGQNPKK Q9UB22 247 -1 -
YCAKVRSNALGTQFTVYDSGQNPKK YQQ4_CAEEL 229 -1 -
FCGKLRSNVFGTSFTVFDNGNKEST Q9W2L5 272 -1 -
YIGKLRSNFLGTKFIMFDTQPPTRH Q9SXI3 193 -1 -
YIGKLRSNFLGTKFTVYENQPPPFN Q9C6B4 176 -1 -
FVGKVRSNVLGTKFTIFDNGVNPER P46_MOUSE 94 -1 -
YVGKLRSNFWGTKFTIYDSQPPHDI Q9M3H9 184 -1 -
YIGKLKSNFLGTKFIVYDTAPAYNS Q9XIF9 173 -1 -
YLGRMRSNFLGTKFTVFDGSQTGAA Q9SQU1 165 -1 -
FGNFNRSDFLGTNFTVYDSQPPHNG Q9MAG9 375 32 -

Motif 3 width=28
Element Seqn Id St Int Rpt
RQELAAVCYETNVLGFKGPRKMSVIVPG TUB_HUMAN 364 11 -
RQELAAVCYETNVLGFKGPRKMSVIVPG TUB_MOUSE 363 11 -
RQELAAVCYETNVLGFKGPRKMSVIVPG TUB_RAT 363 11 -
RQELAAICYETNVLGFKGPRKMSVIIPG TUL3_MOUSE 318 10 -
RQELSAVVYETNVLGFKGPRKMTVIIPG Q9YH17 216 8 -
RQELAAISYETNVLGFKGPRKMSVIIPG TUL3_HUMAN 300 10 -
RQELAAVIYETNVLGFRGPRRMTVIIPG TUL1_HUMAN 400 9 -
RQELAAVVYETNVLGFRGPRRMTVIIPG Q9Z273 401 9 -
SYNIAQITYELNVLGTRGPRRMHCIMNS Q9FRH7 243 27 -
SYKIAQVSYELNVLGTRGPRRMHCAMNS Q9ZP59 241 27 -
CYPIVQVNYELNVLGTRGPRRMQCAMHS Q9ST78 238 25 -
NYPVAHISYELNVLGSRGPRRMQCVMDA O82257 234 24 -
RQELAAVIYETNVLGFKGPRKMTIVMPG Q9UB22 279 7 -
RQELAAVIYETNVLGFKGPRKMTIVMPG YQQ4_CAEEL 261 7 -
RLDLAVIIYDTNILGFKGPRNMTVILPG Q9W2L5 300 3 -
NYAIAQVTYELNVLGKRGPRRMHCTMNS Q9SXI3 243 25 -
SYNIASILYELNVLRTRGPRRMQCIMHS Q9C6B4 219 18 -
REELGVVCYETNVLGFRGPRKMTVILPG P46_MOUSE 129 10 -
SYLVSSISYELNTLWTRGPRRMHCVMNS Q9M3H9 232 23 -
SYNIAQVTYELNLLGTRGPRRMNCIMHS Q9XIF9 223 25 -
SYPIAHISYELNVLGSRGPRRMRCIMDT Q9SQU1 210 20 -
NFEVGHVSYKFNLLKSRGPRRMVSTLRC Q9MAG9 424 24 -

Motif 4 width=18
Element Seqn Id St Int Rpt
LQNKTPVWNDDTQSYVLN TUB_HUMAN 425 33 -
LQNKTPVWNDDTQSYVLN TUB_MOUSE 424 33 -
LQNKTPVWNDDTQSYVLN TUB_RAT 424 33 -
LHNKAPVWNDDTQSYVLN TUL3_MOUSE 379 33 -
LHNKAPVWNDETQSYVLN Q9YH17 277 33 -
LHNKAPVWNSDTQSYVLN TUL3_HUMAN 361 33 -
LHNKPPVWNDDSGSYTLN TUL1_HUMAN 461 33 -
LHNKPPIWNEDSGSYTLN Q9Z273 462 33 -
LKNKQPRWHEQLQCWCLN Q9FRH7 344 73 -
LKNKPPRWHEQLQCWCLN Q9ZP59 349 80 -
LRNKAPRWHEQLQCWCLN Q9ST78 345 79 -
LKNKAPRWHEQLQCWCLN O82257 319 57 -
LSNKSPQWNDETQSYVLN Q9UB22 345 38 -
LSNKSPQWNDETQSYVLN YQQ4_CAEEL 327 38 -
LHNKTPVWNDETQSYVLN Q9W2L5 362 34 -
LKNKAPRWHEQLQCWCLN Q9SXI3 337 66 -
LKNKSPRWHEQLQCWCLN Q9C6B4 295 48 -
LQNKAPSWSDESGAYVLN P46_MOUSE 190 33 -
LKNKAPRWHEQLQCWCLN Q9M3H9 321 61 -
LKTKPPRWLQPLRCWCLN Q9XIF9 307 56 -
LSNKAPRWHEQLRCWCLN Q9SQU1 293 55 -
LKNKAPRWHEHLQCWCLN Q9MAG9 489 37 -

Motif 5 width=17
Element Seqn Id St Int Rpt
FHGRVTQASVKNFQIIH TUB_HUMAN 443 0 -
FHGRVTQASVKNFQIIH TUB_MOUSE 442 0 -
FHGRVTQASVKNFQIIH TUB_RAT 442 0 -
FHGRVTQASVKNFQIVH TUL3_MOUSE 397 0 -
FHGRVTHASVKNFQIVH Q9YH17 295 0 -
FRGRVTQASVKNFQLVH TUL3_HUMAN 379 0 -
FQGRVTQASVKNFQIVH TUL1_HUMAN 479 0 -
FQGRVTQASVKNFQIVH Q9Z273 480 0 -
FRGRVTVASVKNFQLVA Q9FRH7 362 0 -
FRGRVTVASVKNFQLIA Q9ZP59 367 0 -
FRGRVTVASVKNFQLIA Q9ST78 363 0 -
FNGRVTVASVKNFQLVA O82257 337 0 -
FHGRVTQASVKNFQIIH Q9UB22 363 0 -
FHGRVTQASVKNFQIIH YQQ4_CAEEL 345 0 -
FHGRVTQASVKNFQLVH Q9W2L5 380 0 -
FRGRVTVASVKNFQLIA Q9SXI3 355 0 -
FKGRVTVASVKNFQLVA Q9C6B4 313 0 -
FHGRVSRASVKNFQIVH P46_MOUSE 208 0 -
FVGRVTVASVKNFQLVA Q9M3H9 339 0 -
FKGRVTVASVKNFQLMS Q9XIF9 325 0 -
FHGRVTVASVKNFQLVA Q9SQU1 311 0 -
FHGRVTVASVKNFQLVA Q9MAG9 507 0 -

Motif 6 width=20
Element Seqn Id St Int Rpt
PDYIVMQFGRVAEDVFTMDY TUB_HUMAN 463 3 -
PDYIVMQFGRVAEDVFTMDY TUB_MOUSE 462 3 -
PDYIVMQFGRVAEDVFTMDY TUB_RAT 462 3 -
PDYIVMQFGRVADDVFTLDY TUL3_MOUSE 417 3 -
PDYIVMQFGRVADDAFTMDY Q9YH17 315 3 -
PDYIVMQFGRVADDVFTLDY TUL3_HUMAN 399 3 -
PDYIVLQFGRVAEDAFTLDY TUL1_HUMAN 499 3 -
PDYIVLQFGRVAEDAFTLDY Q9Z273 500 3 -
QDKVILQFGKVGKDMFTMDY Q9FRH7 402 23 -
PDKIILQFGKVGKDMFTMDF Q9ZP59 412 28 -
HDTVILQFGKVAKDMFTMDY Q9ST78 419 39 -
HENVILQFGKVGKDVFTMDY O82257 364 10 -
PEYIVMQFGRISDDEFTMDF Q9UB22 383 3 -
PEYIVMQFGRISDDEFTMDF YQQ4_CAEEL 365 3 -
PEYIVMQFGRTSEDVFTMDY Q9W2L5 400 3 -
HDKIILQFGKVGKDTFTMDN Q9SXI3 385 13 -
QDRVILQFGKIGKDIFTMDY Q9C6B4 345 15 -
PDHLVLQFGRVAPNIFTMDF P46_MOUSE 228 3 -
QERVILQFGKIGKDIFTMDY Q9M3H9 368 12 -
HDKIILHFGKVGKDMFTMDY Q9XIF9 372 30 -
SERIILQFGKVGKDMFTMDY Q9SQU1 337 9 -
EETVLLQFGKVGDDTFTMDY Q9MAG9 536 12 -

Motif 7 width=23
Element Seqn Id St Int Rpt
YPLCALQAFAIALSSFDSKLACE TUB_HUMAN 484 1 -
YPLCALQAFAIALSSFDSKLACE TUB_MOUSE 483 1 -
YPLCALQAFAIALSSFDSKLACE TUB_RAT 483 1 -
YPLCALQAFAIGLSSFDSKLACE TUL3_MOUSE 438 1 -
YPLCAVQAFAIALSSFDGKLACE Q9YH17 336 1 -
YPLCAVQAFAISLSSFDSKLACE TUL3_HUMAN 420 1 -
YPLCALQAFAIALSSFDGKLACE TUL1_HUMAN 520 1 -
YPLCALQAFAIALSSFDGKLACE Q9Z273 521 1 -
YPLSAFQAFAICLSSFDTKLACE Q9FRH7 423 1 -
YPLSAFQAFAICLSSFDTKLACE Q9ZP59 433 1 -
YPLSAFQAFAICLTSFDTKLACE Q9ST78 440 1 -
YPISAFQAFTICLSSFDTKIACE O82257 385 1 -
YPLSAVQAFGIAMTSFHGKLACE Q9UB22 404 1 -
YPLSAVQAFGIAMTSFHGKLACE YQQ4_CAEEL 386 1 -
YPLCAMQAFAIALSSFDGKIACE Q9W2L5 421 1 -
YPLSAFQAFAICLSSFDTKLACE Q9SXI3 406 1 -
YPISAFQAFAICLSSFDTKPVCE Q9C6B4 366 1 -
YPLCPLQAFAICLSSFDGKLACE P46_MOUSE 249 1 -
YPLSAFQAFAICLTSFDTKPACE Q9M3H9 389 1 -
YPLSAFQAFAISLSTFDTKLACE Q9XIF9 393 1 -
YPISAFQAFAICLSSFETRIACE Q9SQU1 358 1 -
QPLSAFQAFAICLTSFGTKLACE Q9MAG9 557 1 -