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PR01549

Identifier
AUTOINDCRSYN  [View Relations]  [View Alignment]  
Accession
PR01549
No. of Motifs
7
Creation Date
02-JUN-2001
Title
Autoinducer synthesis protein signature 
Database References

PROSITE; PS00949 AUTOINDUCERS_SYNTH
BLOCKS; BL00949
PFAM; PF00765 Autoind_synth
INTERPRO; IPR001690 Autoi
Literature References
1. BASSLER, B.L. 
How bacteria talk to each other: regulation of gene expression by quorum 
sensing.
CURR.OPIN.MICROBIOL. 2 582-587 (1999).
 
2. SURETTE, M.G., MILLER, M.B. AND BASSLER, B.L.
Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio 
harveyi: A new family of genes responsible for autoinducer production.
PROC.NATL.ACAD.SCI.U.S.A. 96 1639-1644 (1999).
 
3. FUQUA W.C. AND WINANS S.C.
A LuxR-LuxI type regulatory system activates Agrobacterium Ti plasmid 
conjugal transfer in the presence of a plant tumor metabolite.
J.BACTERIOL. 176 2796-2806 (1994). 
 
4. ENGEBRECHT, J. AND SILVERMAN, M.
Nucleotide sequence of the regulatory locus controlling expression of 
bacterial genes for bioluminescence. 
NUCLEIC ACIDS RES. 15 10455-10467 (1987). 
 
5. SWIFT, S., WINSON, M.K., CHAN, P.F., BAINTON, N.J., BIRDSALL, M.,
REEVES, P.J., REES, C.E.D., CHHABRA, S.R., HILL, P.J., THROUP, J.P.,
BYCROFT, B.W., SALMOND, G.P.C., WILLIAMS, P. AND STEWART, G.S.A.B.
A novel strategy for the isolation of luxI homologues: evidence for the
widespread distribution of a LuxR:LuxI superfamily in enteric bacteria.
MOL.MICROBIOL. 10 511-520 (1993). 
 
6. LATIFI, A., WINSON, M.K., FOGLINO, M., BYCROFT, B.W., STEWART, G.S.A.B.,
LAZDUNSKI, A. AND WILLIAMS, P.
Multiple homologues of LuxR and LuxI control expression of virulence
determinants and secondary metabolites through quorum sensing in
Pseudomonas aeruginosa PAO1.
MOL.MICROBIOL. 17 333-343 (1995). 

Documentation
Bacterial species have many methods of controlling gene expression and cell
growth. Regulation of gene expression in response to changes in cell density
is termed quorum sensing [1,2]. Quorum-sensing bacteria produce, release and
respond to hormone-like molecules (autoinducers) that accumulate in the 
external environment as the cell population grows. Once a threshold of these
molecules is reached, a signal transduction cascade is triggered that 
ultimately leads to behavioural changes in the bacterium [2]. Autoinducers
are thus clearly important mediators of molecular communication. 
 
Conjugal transfer of Agrobacterium octopine-type Ti plasmids is activated 
by octopine, a metabolite released from plant tumours [3]. Octopine causes 
conjugal donors to secrete a pheromone, Agrobacterium autoinducer (AAI),
and exogenous AAI further stimulates conjugation [3]. The putative AAI 
synthase and an AAI-responsive transcriptional regulator have been found 
to be encoded by the Ti plasmid traI and traR genes, respectively [3]. TraR
and TraI are similar to the LuxR and LuxI regulatory proteins of Vibrio
fischeri, and AAI is similar in structure to the diffusable V.fischeri
autoinducer, the inducing ligand of LuxR [3]. TraR activates target genes
in the presence of AAI and also activates traR and traI themselves, creating
two positive-feedback loops [3]. TraR-AAI-mediated activation in wild-type
Agrobacterium strains is enhanced by culturing on solid media, suggesting a
possible role in cell density sensing [3]. 
 
Production of light by the marine bacterium Vibrio fischeri and by
recombinant hosts containing cloned lux genes is controlled by the density
of the culture [4]. Density-dependent regulation of lux gene expression has
been shown to require a locus consisting of the luxR and luxI genes [4].
 
In these and other Gram-negative bacteria, N-(3-oxohexanoyl)-L-homoserine 
lactone (OHHL) acts as the autoinducer by binding to transcriptional
regulatory proteins and activating them [5,6]. OHHL and related molecules,
such as N-butanoyl- (BHL), N-hexanoyl- (HHL) and N-oxododecanoyl- (PAI) 
homoserine lactones, are produced by a family of proteins that share a high
level of sequence similarity.
 
AUTOINDCRSYN is a 7-element fingerprint that provides a signature for 
autoinducer synthesis proteins. The fingerprint was derived from an initial
alignment of 18 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length. Two iterations on SPTR39_15f
were required to reach convergence, at which point a true set comprising 30
sequences was identified. Several partial matches were also found, all of
which are autoinducer synthesis proteins that fail to make significant
matches with one or more motifs.
Summary Information
  30 codes involving  7 elements
1 codes involving 6 elements
3 codes involving 5 elements
1 codes involving 4 elements
1 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
730303030303030
61111011
53333030
41111000
31110000
21010000
1234567
True Positives
AHYI_AERHY    ASAI_AERSA    CARI_ERWCA    EAGI_ENTAG    
ECHI_ERWCH ESAI_ERWST EXPI_ERWCA EXPI_ERWCH
LUXI_VIBFI LUXJ_VIBFI O30345 O66168
O85693 O85823 PHZI_PSEAR PHZI_PSEFL
PSYI_PSESZ Q9L3I9 Q9L6U6 Q9R9G9
Q9RH44 Q9XDD0 RHLI_PSEAE SWRI_SERLI
TRAI_AGRT5 TRAI_AGRT6 TRAI_RHISN VANI_VIBAN
YENI_YEREN YUKI_YERRU
True Positive Partials
Codes involving 6 elements
LASI_PSEAE
Codes involving 5 elements
Q9L6U4 Q9ZIU1 SOLI_BURSO
Codes involving 4 elements
O30761
Codes involving 3 elements
Q9KJ70
Codes involving 2 elements
RAII_RHIET
Sequence Titles
AHYI_AERHY  AUTOINDUCER SYNTHESIS PROTEIN AHYI - Aeromonas hydrophila. 
ASAI_AERSA AUTOINDUCER SYNTHESIS PROTEIN ASAI - Aeromonas salmonicida.
CARI_ERWCA AUTOINDUCER SYNTHESIS PROTEIN CARI - Erwinia carotovora.
EAGI_ENTAG AUTOINDUCER SYNTHESIS PROTEIN EAGI - Enterobacter agglomerans.
ECHI_ERWCH AUTOINDUCER SYNTHESIS PROTEIN ECHI - Erwinia chrysanthemi.
ESAI_ERWST AUTOINDUCER SYNTHESIS PROTEIN ESAI - Erwinia stewartii.
EXPI_ERWCA AUTOINDUCER SYNTHESIS PROTEIN EXPI - Erwinia carotovora.
EXPI_ERWCH AUTOINDUCER SYNTHESIS PROTEIN EXPI - Erwinia chrysanthemi.
LUXI_VIBFI AUTOINDUCER SYNTHESIS PROTEIN LUXI - Vibrio fischeri.
LUXJ_VIBFI AUTOINDUCER SYNTHESIS PROTEIN LUXI - Vibrio fischeri.
O30345 LUXI HOMOLOG - Erwinia carotovora subsp. betavasculorum.
O66168 TRAI - Agrobacterium tumefaciens.
O85693 ACYL HOMOSERINE LACTONE BIOSYNTHETIC PROTEIN - Pseudomonas syringae (pv. syringae).
O85823 N-ACYLHOMOSERINE LACTONE SYNTHASE YSPI - Yersinia pseudotuberculosis.
PHZI_PSEAR AUTOINDUCER SYNTHESIS PROTEIN PHZI - Pseudomonas aureofaciens.
PHZI_PSEFL AUTOINDUCER SYNTHESIS PROTEIN PHZI - Pseudomonas fluorescens.
PSYI_PSESZ AUTOINDUCER SYNTHESIS PROTEIN PSYI - Pseudomonas syringae (pv. tabaci).
Q9L3I9 N-ACYL HOMOSERINE LACTONE SYNTHASE, SMAI - Serratia sp. ATCC39006.
Q9L6U6 PUTATIVE ACYLHOMOSERINE LACTONE SYNTHASE - Pseudomonas fluorescens.
Q9R9G9 AUTOINDUCER SYNTHASE PHZI - Pseudomonas chlororaphis (Pseudomonas fluorescens biotype D).
Q9RH44 HOMOSERINE LACTONE SYNTHASE YPEI - Yersinia pestis.
Q9XDD0 N-ACYLHOMOSERINE LACTONE SYNTHASE YPSI - Yersinia pseudotuberculosis.
RHLI_PSEAE AUTOINDUCER SYNTHESIS PROTEIN RHLI - Pseudomonas aeruginosa.
SWRI_SERLI AUTOINDUCER SYNTHESIS PROTEIN SWRI - Serratia liquefaciens.
TRAI_AGRT5 AUTOINDUCER SYNTHESIS PROTEIN TRAI - Agrobacterium tumefaciens.
TRAI_AGRT6 AUTOINDUCER SYNTHESIS PROTEIN TRAI - Agrobacterium tumefaciens.
TRAI_RHISN PROBABLE AUTOINDUCER SYNTHESIS PROTEIN TRAI - Rhizobium sp. (strain NGR234).
VANI_VIBAN AUTOINDUCER SYNTHESIS PROTEIN VANI - Vibrio anguillarum.
YENI_YEREN AUTOINDUCER SYNTHESIS PROTEIN YENI - Yersinia enterocolitica.
YUKI_YERRU AUTOINDUCER SYNTHESIS PROTEIN YUKI - Yersinia ruckeri.

LASI_PSEAE AUTOINDUCER SYNTHESIS PROTEIN LASI - Pseudomonas aeruginosa.

Q9L6U4 PUTATIVE ACYLHOMOSERINE LACTONE SYNTHASE - Pseudomonas fluorescens.
Q9ZIU1 PUTATIVE ACYL HOMOSERINE LACTONE SYNTHASE - Burkholderia cepacia (Pseudomonas cepacia).
SOLI_BURSO AUTOINDUCER SYNTHESIS PROTEIN SOLI - Burkholderia solanacearum (Pseudomonas solanacearum).

O30761 AUTOINDUCER SYNTHASE - Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides).

Q9KJ70 AHL-SYNTHASE CINI - Rhizobium leguminosarum.

RAII_RHIET AUTOINDUCER SYNTHESIS PROTEIN RAII - Rhizobium etli.
Scan History
SPTR39_15f 2  185  NSINGLE    
Initial Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
ELFTLRKETFKDRLNWAVQC CARI_ERWCA 19 19 -
EVFTLRKDTFKDRLDWAVNC ECHI_ERWCH 19 19 -
EVFALRKGTFKDRLDWTVNC EXPI_ERWCH 19 19 -
DLYKLRKITFKDRLDWAVNC EAGI_ENTAG 19 19 -
ELFTLRKETFKDRLNWAVKC EXPI_ERWCA 19 19 -
EIFSLREITFKDRLDWKVTC YENI_YEREN 19 19 -
ELFSLRKKTFKDRLDWLVNC SWRI_SERLI 19 19 -
ELYKLRKKTFSDRLGWEVIC ESAI_ERWST 19 19 -
QMHRLRATVFGGRLEWDVSI TRAI_AGRT5 20 20 -
TLYSMRKKIFSDRLEWKVRV PSYI_PSESZ 22 22 -
QMHRLRAEVFGNRLKWDVAI TRAI_AGRT6 20 20 -
GILSLRYQVFKRRLEWDLVS LUXJ_VIBFI 20 20 -
SHHELRARVFSDRLGWEVNV TRAI_RHISN 20 20 -
GILSLRYQVFKQRLEWDLVV LUXI_VIBFI 20 20 -
MLGRFRHEQFVEKLGWRLPA PHZI_PSEAR 18 18 -
MLGRFRHEQFVEKLGWRLPI PHZI_PSEFL 18 18 -
ELYRFRNRVFSDRLGWDVES ASAI_AERSA 19 19 -
ELGRYRHQVFIEKLGWDVVS RHLI_PSEAE 19 19 -

Motif 2 width=23
Element Seqn Id St Int Rpt
TDGMEFDQYDNNNTTYLFGIKDN CARI_ERWCA 39 0 -
INGMEFDEYDNEHTTYLLGVKEG ECHI_ERWCH 39 0 -
INGMEFDEYDNEHTTYLLGVKEG EXPI_ERWCH 39 0 -
SNDMEFDEFDNSGTRYMLGIYDN EAGI_ENTAG 39 0 -
INGMEFDQYDDDNATYLFGVEGD EXPI_ERWCA 39 0 -
IDGKESDQYDDENTNYILGTIDD YENI_YEREN 39 0 -
ENNMEFDEYDNRHATYIFGTYQN SWRI_SERLI 39 0 -
SQGMESDEFDGPGTRYILGICEG ESAI_ERWST 39 0 -
IAGEERDQYDNFKPSYLLAITDS TRAI_AGRT5 40 0 -
SHAFEFDEYDNAATTYLVGSWNG PSYI_PSESZ 42 0 -
EDGGERDQYDELSPTYILATFGG TRAI_AGRT6 40 0 -
EDNLESDEYDNSNAEYIYACDDA LUXJ_VIBFI 40 0 -
VGGCESDTFDDLQPTYILAVSSN TRAI_RHISN 40 0 -
ENNLESDEYDNSNAEYIYACDDT LUXI_VIBFI 40 0 -
QAGCEWDQYDTEHARYLLAFNED PHZI_PSEAR 41 3 -
QAGYEWDQYDTEHARYLLAFNEH PHZI_PSEFL 41 3 -
HRGLEQDSFDTPDTHWVLIEDEE ASAI_AERSA 39 0 -
VRDQEFDQFDHPQTRYIVAMSRQ RHLI_PSEAE 42 3 -

Motif 3 width=19
Element Seqn Id St Int Rpt
TVICSLRFIETKYPNMITG CARI_ERWCA 62 0 -
KVICSVRFIEIKYPNMITG ECHI_ERWCH 62 0 -
KIICSVRFIEMKYPNMITG EXPI_ERWCH 62 0 -
QLVCSVRFIDLRLPNMITH EAGI_ENTAG 62 0 -
QVICSSRLIETKYPNMITG EXPI_ERWCA 62 0 -
TIVCSVRFIDMKYPTMITG YENI_YEREN 62 0 -
HVICSLRFIETKYPNMISD SWRI_SERLI 62 0 -
QLVCSVRFTSLDRPNMITH ESAI_ERWST 62 0 -
RVAGCVRLLPACGPTMLEQ TRAI_AGRT5 64 1 -
VPLAGLRLINTCDPYMLEG PSYI_PSESZ 65 0 -
RVVGCARLLAPSGPTMLER TRAI_AGRT6 64 1 -
EVNGCWRLLPTTGDYMLKT LUXJ_VIBFI 64 1 -
RVVGCARLLPALGPTMVAN TRAI_RHISN 64 1 -
NVSGCWRLLPTTGDYMLKS LUXI_VIBFI 64 1 -
AIVGCARLIPTTFPNLLEG PHZI_PSEAR 65 1 -
SIVGCARLIPTTFPNLLEG PHZI_PSEFL 65 1 -
GLCGCIRLLSCAQDYMLPS ASAI_AERSA 62 0 -
GICGCARLLPTTDAYLLKD RHLI_PSEAE 65 0 -

Motif 4 width=13
Element Seqn Id St Int Rpt
GNYLESSRFFVDK CARI_ERWCA 94 13 -
GNYIESSRFFVDR ECHI_ERWCH 94 13 -
GNYIESSRFFVDR EXPI_ERWCH 94 13 -
GDYIESSRFFVDK EAGI_ENTAG 94 13 -
GKYIESSRFFVDK EXPI_ERWCA 94 13 -
DGFIESSRFFVEK YENI_YEREN 94 13 -
GNYVEASRLFIDK SWRI_SERLI 95 14 -
AYGTESSRFFVDK ESAI_ERWST 93 12 -
SGMVESSRFCVDT TRAI_AGRT5 97 14 -
AAMAESSRFFVDT PSYI_PSESZ 97 13 -
TAMIETSRFCVDT TRAI_AGRT6 97 14 -
PNIVELSRFAVGK LUXJ_VIBFI 97 14 -
SSMVESSRFCVDT TRAI_RHISN 97 14 -
PNIVELSRFAVGK LUXI_VIBFI 97 14 -
PAIWEMTRFTTRE PHZI_PSEAR 97 13 -
PAIWEMTRFTTRE PHZI_PSEFL 97 13 -
SDVWELTRLAIDA ASAI_AERSA 95 14 -
PSVWELSRYAASA RHLI_PSEAE 97 13 -

Motif 5 width=22
Element Seqn Id St Int Rpt
ISSMLFLSMINYSKDKGYDGIY CARI_ERWCA 119 12 -
ACVTLFLAMINYARKYHYDGIL ECHI_ERWCH 119 12 -
ACLTLFLAMINYARKYHYDGIL EXPI_ERWCH 119 12 -
ISYVLFLSMINYARHHGHTGIY EAGI_ENTAG 119 12 -
VSTMFFLATVNYSKSKGYDGVY EXPI_ERWCA 119 12 -
LSTILFLAMVNYARDRGHKGIL YENI_YEREN 119 12 -
ISAMLFLSMINYARNCGYEGIY SWRI_SERLI 120 12 -
ISQVLFLAMVNWAQNNAYGNIY ESAI_ERWST 118 12 -
ATLTLFAGIIEWSMASGYTEIV TRAI_AGRT5 123 13 -
LTEMLLFSMHNHAALSGLQSII PSYI_PSESZ 122 12 -
ATLTMFAGIIEWSMANGYDEIV TRAI_AGRT6 123 13 -
ITMKLFQAIYKHAVSQGITEYV LUXJ_VIBFI 121 11 -
ATLTMFAGIIEWSVANRYTEIV TRAI_RHISN 123 13 -
ITMKLFEAIYKHAVSQGITEYV LUXI_VIBFI 121 11 -
LAMPLFWRSLKTASLAGADAIV PHZI_PSEAR 112 2 -
LAMPLFWKTLKTASLAGADAIV PHZI_PSEFL 112 2 -
LTCVIFREVYAFARAKGIRELV ASAI_AERSA 120 12 -
LAMKIFWSSLQCAWYLGASSVV RHLI_PSEAE 115 5 -

Motif 6 width=22
Element Seqn Id St Int Rpt
TIVSHPMLTILKRSGWGIRVVE CARI_ERWCA 141 0 -
TIVSHPMLTLLKRSGWRISIIQ ECHI_ERWCH 141 0 -
TIVSHPMLTLLKRSGWRISIIQ EXPI_ERWCH 141 0 -
TIVSRAMLTIAKRSGWEIEVIK EAGI_ENTAG 141 0 -
TIVSHPMLTILKRSGWKISIVE EXPI_ERWCA 141 0 -
TVVSRGMFILLKRSGWNITVLN YENI_YEREN 141 0 -
AIISHPMRIIFQRSGWHISVVK SWRI_SERLI 142 0 -
TIVSRAMLKILTRSGWQIKVIK ESAI_ERWST 140 0 -
TATDLRFERILKRAGWPMRRLG TRAI_AGRT5 145 0 -
TVVSKAMARIVRKSGWEHHVLS PSYI_PSESZ 144 0 -
TATDLRFERILKRAGWPMTRLG TRAI_AGRT6 145 0 -
TVTSIAIERFLKRIKVPCHRIG LUXJ_VIBFI 143 0 -
TVTDLRFERILARVGWPLQRIG TRAI_RHISN 145 0 -
TVTSTAIERFLKRIKVPCHRIG LUXI_VIBFI 143 0 -
GIVNSTMERYYKINGVHYERLG PHZI_PSEAR 134 0 -
GIVNSTMERYYKINGVKYERLG PHZI_PSEFL 134 0 -
AVVSLPVERIFRRLGLPIERLG ASAI_AERSA 142 0 -
AVTTTAMERYFVRNGVILQRLG RHLI_PSEAE 137 0 -

Motif 7 width=18
Element Seqn Id St Int Rpt
QGLSEKEERVYLVFLPVD CARI_ERWCA 163 0 -
QGLSEKQERIYLLHLPTD ECHI_ERWCH 163 0 -
QGLSEKQEKIYLLHLPTD EXPI_ERWCH 163 0 -
EGFVSENEPIYLLRLPID EAGI_ENTAG 163 0 -
QGMSEKHERVYLLFLPVD EXPI_ERWCA 163 0 -
QGESEKNEVIYLLHLGID YENI_YEREN 163 0 -
TGCSEKNKNIYLIYMPID SWRI_SERLI 164 0 -
EAFLTEKERIYLLTLPAG ESAI_ERWST 162 0 -
EPTAIGNTIAIAGRLPAD TRAI_AGRT5 167 0 -
TGEASPGETVLLLEMPVT PSYI_PSESZ 166 0 -
EPVAIGNTVAVAGHLPAD TRAI_AGRT6 167 0 -
EIHLLGNTRSVVLSMPIN LUXJ_VIBFI 167 2 -
EPRPIGATVAVAGTLPAK TRAI_RHISN 167 0 -
EIHVLGDTKSVVLSMPIN LUXI_VIBFI 167 2 -
PVTVHQNEKILAIKLSAH PHZI_PSEAR 156 0 -
SVIDHQNEKILAIKLSAH PHZI_PSEFL 156 0 -
QAVDLGAVRGVGIRFHLD ASAI_AERSA 166 2 -
PPQKVKGETLVAISFPAY RHLI_PSEAE 159 0 -
Final Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
ELYKLRKKTFSDRLGWEVIC ESAI_ERWST 19 19 -
QMHRLRATVFGGRLEWDVSI O66168 20 20 -
QMHRLRATVFGGRLEWDVSI TRAI_AGRT5 20 20 -
DLYGLRKEVFADRLNWKVNV Q9L6U6 21 21 -
EIFTLRKITFKDRLDWKVTC Q9XDD0 19 19 -
TLYSMRKKIFSDRLEWKVRV PSYI_PSESZ 22 22 -
QMHRLRAEVFGNRLKWDVAI TRAI_AGRT6 20 20 -
TLYALRKKIFSDRLEWKVRV O85693 22 22 -
GILSLRYQVFKRRLEWDLVS LUXJ_VIBFI 20 20 -
SHHELRARVFSDRLGWEVNV TRAI_RHISN 20 20 -
GILSLRYQVFKQRLEWDLVV LUXI_VIBFI 20 20 -
ELFTLRKETFKDRLNWAVQC CARI_ERWCA 19 19 -
MLGRFRHEQFVEKLGWRLPA PHZI_PSEAR 18 18 -
MLGRFRHEQFVEKLGWRLPA Q9R9G9 18 18 -
MLGRFRHEQFVEKLGWRLPI PHZI_PSEFL 18 18 -
ELYRFRNRVFSDRLGWDVES ASAI_AERSA 19 19 -
ELYRFRNRVFSDRLGWDVES AHYI_AERHY 19 19 -
ELGRYRHQVFIEKLGWDVVS RHLI_PSEAE 19 19 -
DLYRLRKKTFKDRLQWAVNC YUKI_YERRU 19 19 -
ELFTLRKETFKDRLNWAVKC EXPI_ERWCA 19 19 -
EIFTLRKITFKDRLDWKVTC Q9RH44 19 19 -
SLLKLRYKVFSQRLQWELKT VANI_VIBAN 20 20 -
EIFSLREITFKDRLDWKVTC YENI_YEREN 19 19 -
DLYKLRKITFKDRLDWAVNC EAGI_ENTAG 19 19 -
ELFSLRKKTFKDRLDWLVNC SWRI_SERLI 19 19 -
ELFSLRKKTFKDRLNWRVSC Q9L3I9 19 19 -
DLYKLRKKTFKDRLNWEVNC O85823 19 19 -
EVFALRKGTFKDRLDWTVNC EXPI_ERWCH 19 19 -
EVFTLRKDTFKDRLDWAVNC ECHI_ERWCH 19 19 -
ELFTLRKETFKDRLNWAVQC O30345 19 19 -

Motif 2 width=23
Element Seqn Id St Int Rpt
IDGKESDQYDDENTNYLLGTIDD Q9RH44 39 0 -
SNDMEFDEYDNPNTRYLLGIYGN YUKI_YERRU 39 0 -
NRGMETDEYDVPEAHYLYAKEEQ VANI_VIBAN 40 0 -
TDGMEFDQYDNNNTTYLFGIKDN CARI_ERWCA 39 0 -
TDGMEFDQYDNNNTTYLFGIKDN O30345 39 0 -
INGMEFDEYDNEHTTYLLGVKEG ECHI_ERWCH 39 0 -
INGMEFDEYDNEHTTYLLGVKEG EXPI_ERWCH 39 0 -
SNGMEFDEYDNSDTRYLLGIYQG O85823 39 0 -
SNDMEFDEFDNSGTRYMLGIYDN EAGI_ENTAG 39 0 -
IDGKESDQYDDENTNYLLGTIDD Q9XDD0 39 0 -
INGMEFDQYDDDNATYLFGVEGD EXPI_ERWCA 39 0 -
IDGKESDQYDDENTNYILGTIDD YENI_YEREN 39 0 -
ENNMEFDEYDNRHATYIFGTYQN SWRI_SERLI 39 0 -
EQNMEFDVYDNKNTTYIFGVYEG Q9L3I9 39 0 -
SQGMESDEFDGPGTRYILGICEG ESAI_ERWST 39 0 -
IAGEERDQYDNFKPSYLLAITDS O66168 40 0 -
IAGEERDQYDNFKPSYLLAITDS TRAI_AGRT5 40 0 -
RDDIEFDEYDNERTTYLVGTWKN Q9L6U6 41 0 -
SHAFEFDEYDNAATTYLVGSWNG PSYI_PSESZ 42 0 -
EDGGERDQYDELSPTYILATFGG TRAI_AGRT6 40 0 -
SQAFEFDDYDSAAATYLIGSWNG O85693 42 0 -
EDNLESDEYDNSNAEYIYACDDA LUXJ_VIBFI 40 0 -
VGGCESDTFDDLQPTYILAVSSN TRAI_RHISN 40 0 -
ENNLESDEYDNSNAEYIYACDDT LUXI_VIBFI 40 0 -
QAGCEWDQYDTEHARYLLAFNED PHZI_PSEAR 41 3 -
QPGCEWDQYDTEHARYLLAFNED Q9R9G9 41 3 -
QAGYEWDQYDTEHARYLLAFNEH PHZI_PSEFL 41 3 -
HRGLEQDSFDTPDTHWVLIEDEE ASAI_AERSA 39 0 -
HRGLEQDSFDTPDTHWVLIEDEE AHYI_AERHY 39 0 -
VRDQEFDQFDHPQTRYIVAMSRQ RHLI_PSEAE 42 3 -

Motif 3 width=19
Element Seqn Id St Int Rpt
QLICSVRFIELHLPNMITH O85823 62 0 -
QLVCSVRFIDLRLPNMITH EAGI_ENTAG 62 0 -
TLVCSVRFVEMQYPTMITG Q9RH44 62 0 -
TLVCSVRFVEMQYPTMITG Q9XDD0 62 0 -
QVICSSRLIETKYPNMITG EXPI_ERWCA 62 0 -
TIVCSVRFIDMKYPTMITG YENI_YEREN 62 0 -
HVICSLRFIETKYPNMISD SWRI_SERLI 62 0 -
SIICSLRFIETRFPNMIID Q9L3I9 62 0 -
QLVCSVRFTSLDRPNMITH ESAI_ERWST 62 0 -
RVAGCVRLLPACGPTMLEQ O66168 64 1 -
RVAGCVRLLPACGPTMLEQ TRAI_AGRT5 64 1 -
VPLAGLRLINTLDPYMVEG Q9L6U6 64 0 -
VPLAGLRLINTCDPYMLEG PSYI_PSESZ 65 0 -
RVVGCARLLAPSGPTMLER TRAI_AGRT6 64 1 -
VPLAGLRLINTCDPYMLDG O85693 65 0 -
EVNGCWRLLPTTGDYMLKT LUXJ_VIBFI 64 1 -
RVVGCARLLPALGPTMVAN TRAI_RHISN 64 1 -
NVSGCWRLLPTTGDYMLKS LUXI_VIBFI 64 1 -
AIVGCARLIPTTFPNLLEG PHZI_PSEAR 65 1 -
AIVGCARLIPTTFPNLLEG Q9R9G9 65 1 -
SIVGCARLIPTTFPNLLEG PHZI_PSEFL 65 1 -
GLCGCIRLLSCAQDYMLPS ASAI_AERSA 62 0 -
GLCGCIRLLSCAKDYMLPS AHYI_AERHY 62 0 -
GICGCARLLPTTDAYLLKD RHLI_PSEAE 65 0 -
KIICSVRFIEMKYPNMITG EXPI_ERWCH 62 0 -
KVICSVRFIEIKYPNMITG ECHI_ERWCH 62 0 -
TVICSLRFIETKYPNMITG O30345 62 0 -
TVICSLRFIETKYPNMITG CARI_ERWCA 62 0 -
HLVGCWRILPTTSRYMLKD VANI_VIBAN 64 1 -
QLICSVRFIELHRPNMITH YUKI_YERRU 62 0 -

Motif 4 width=13
Element Seqn Id St Int Rpt
PNIVELSRFAVGK LUXI_VIBFI 97 14 -
GNYLESSRFFVDK CARI_ERWCA 94 13 -
GNYLESTRFFVDK O30345 94 13 -
GNYIESSRFFVDR ECHI_ERWCH 94 13 -
GNYIESSRFFVDR EXPI_ERWCH 94 13 -
RGYIESSRFFVDK O85823 94 13 -
GDYIESSRFFVDK EAGI_ENTAG 94 13 -
DGFIESSRFFVEK Q9RH44 94 13 -
DGFIESSRFFVEK Q9XDD0 94 13 -
GKYIESSRFFVDK EXPI_ERWCA 94 13 -
DGFIESSRFFVEK YENI_YEREN 94 13 -
GNYVEASRLFIDK SWRI_SERLI 95 14 -
GNHIEASRLFIDK Q9L3I9 94 13 -
AYGTESSRFFVDK ESAI_ERWST 93 12 -
SGMVESSRFCVDT O66168 97 14 -
SGMVESSRFCVDT TRAI_AGRT5 97 14 -
ALMAESSRFFVDK Q9L6U6 96 13 -
AAMAESSRFFVDT PSYI_PSESZ 97 13 -
TAMIETSRFCVDT TRAI_AGRT6 97 14 -
AGMAESSRFFVDT O85693 97 13 -
PNIVELSRFAVGK LUXJ_VIBFI 97 14 -
SSMVESSRFCVDT TRAI_RHISN 97 14 -
PAIWEMTRFTTRE PHZI_PSEAR 97 13 -
PAIWEMTRFTTRE Q9R9G9 97 13 -
PAIWEMTRFTTRE PHZI_PSEFL 97 13 -
SDVWELTRLAIDA ASAI_AERSA 95 14 -
NDVWELTRLAIDA AHYI_AERHY 95 14 -
PSVWELSRYAASA RHLI_PSEAE 97 13 -
KEIYELSRFAVDK VANI_VIBAN 97 14 -
GNYIESSRFFVDK YUKI_YERRU 94 13 -

Motif 5 width=22
Element Seqn Id St Int Rpt
VSTMFFLATVNYSKSKGYDGVY EXPI_ERWCA 119 12 -
LSTILFLAMVNYARDRGHKGIL YENI_YEREN 119 12 -
ISAMLFLSMINYARNCGYEGIY SWRI_SERLI 120 12 -
ISLLLFLSMINYARSLGYEGIY Q9L3I9 119 12 -
ISQVLFLAMVNWAQNNAYGNIY ESAI_ERWST 118 12 -
ATLTLFAGIIEWSMASGYTEIV O66168 123 13 -
ATLTLFAGIIEWSMASGYTEIV TRAI_AGRT5 123 13 -
LTEMLLLCMHNHAAHSGLESII Q9L6U6 121 12 -
LTEMLLFSMHNHAALSGLQSII PSYI_PSESZ 122 12 -
ATLTMFAGIIEWSMANGYDEIV TRAI_AGRT6 123 13 -
LTEMLLFSMHNHAASAGLESII O85693 122 12 -
ITMKLFQAIYKHAVSQGITEYV LUXJ_VIBFI 121 11 -
ATLTMFAGIIEWSVANRYTEIV TRAI_RHISN 123 13 -
ITMKLFEAIYKHAVSQGITEYV LUXI_VIBFI 121 11 -
LAMPLFWRSLKTASLAGADAIV PHZI_PSEAR 112 2 -
LAMPLFWRSLKTASLAGADAIV Q9R9G9 112 2 -
LAMPLFWKTLKTASLAGADAIV PHZI_PSEFL 112 2 -
LTCVIFREVYAFARAKGIRELV ASAI_AERSA 120 12 -
LTCIIFREVYAFAKAQGIRELV AHYI_AERHY 120 12 -
LAMKIFWSSLQCAWYLGASSVV RHLI_PSEAE 115 5 -
VTLQMFQSLYHHAQQYHINAYV VANI_VIBAN 121 11 -
ISSMLFLSMINYSRDKGYDGIY O30345 119 12 -
ISYVLFLSMINYARHHGHTGIY EAGI_ENTAG 119 12 -
ISYLFFLSIINYSRHNGYTGIY O85823 119 12 -
ACLTLFLAMINYARKYHYDGIL EXPI_ERWCH 119 12 -
ISYVLFLAVINYTRHHKHTGIY YUKI_YERRU 119 12 -
ISSMLFLSMINYSKDKGYDGIY CARI_ERWCA 119 12 -
ACVTLFLAMINYARKYHYDGIL ECHI_ERWCH 119 12 -
LSAILFLSMVNYARNRGYKGIL Q9RH44 119 12 -
LSAILFLSMVNYARNCGYKGIL Q9XDD0 119 12 -

Motif 6 width=22
Element Seqn Id St Int Rpt
GIVNSTMERYYKINGVKYERLG PHZI_PSEFL 134 0 -
AIVSHPMLIIFQRSGWQVSIVE Q9L3I9 141 0 -
TIVSRAMLKILTRSGWQIKVIK ESAI_ERWST 140 0 -
TATDLRFERILKRAGWPMRRLG O66168 145 0 -
TATDLRFERILKRAGWPMRRLG TRAI_AGRT5 145 0 -
TVVSNAMGRIVRNAGWHYEILD Q9L6U6 143 0 -
TVVSKAMARIVRKSGWEHHVLS PSYI_PSESZ 144 0 -
TATDLRFERILKRAGWPMTRLG TRAI_AGRT6 145 0 -
TVVSKAMARIVRKSGWEHRVLA O85693 144 0 -
TVTSIAIERFLKRIKVPCHRIG LUXJ_VIBFI 143 0 -
TVTDLRFERILARVGWPLQRIG TRAI_RHISN 145 0 -
TVTSTAIERFLKRIKVPCHRIG LUXI_VIBFI 143 0 -
GIVNSTMERYYKINGVHYERLG PHZI_PSEAR 134 0 -
GIVNSTMERYYKINGVHYERLG Q9R9G9 134 0 -
AIISHPMRIIFQRSGWHISVVK SWRI_SERLI 142 0 -
AVVSLPVERIFRRLGLPIERLG ASAI_AERSA 142 0 -
AVVSLPVERIFRRLGLPIERLG AHYI_AERHY 142 0 -
AVTTTAMERYFVRNGVILQRLG RHLI_PSEAE 137 0 -
TVTSASVEKLIKRMGIPCERLG VANI_VIBAN 143 0 -
TIVSRAMLTILKRSGWQFDVIK YUKI_YERRU 141 0 -
TIVSHPMLTILKRSGWGIRVVE CARI_ERWCA 141 0 -
TIVSHPMLTILKRSGWGISVVE O30345 141 0 -
TIVSHPMLTLLKRSGWRISIIQ ECHI_ERWCH 141 0 -
TIVSHPMLTLLKRSGWRISIIQ EXPI_ERWCH 141 0 -
TIVSRAMLTILKRSGWQVEVIK O85823 141 0 -
TIVSRAMLTIAKRSGWEIEVIK EAGI_ENTAG 141 0 -
TVVSRGMYTILKRSGWGITVIN Q9RH44 141 0 -
TVVSRGMYTILKRSGWGITVIN Q9XDD0 141 0 -
TIVSHPMLTILKRSGWKISIVE EXPI_ERWCA 141 0 -
TVVSRGMFILLKRSGWNITVLN YENI_YEREN 141 0 -

Motif 7 width=18
Element Seqn Id St Int Rpt
EAFLTEKERIYLLTLPAG ESAI_ERWST 162 0 -
EPTAIGNTIAIAGRLPAD O66168 167 0 -
EPTAIGNTIAIAGRLPAD TRAI_AGRT5 167 0 -
VGEAAPGEKVLLLDMPVS Q9L6U6 165 0 -
TGEASPGETVLLLEMPVT PSYI_PSESZ 166 0 -
EPVAIGNTVAVAGHLPAD TRAI_AGRT6 167 0 -
TGEASPGETVLLLDMPVN O85693 166 0 -
EIHLLGNTRSVVLSMPIN LUXJ_VIBFI 167 2 -
EPRPIGATVAVAGTLPAK TRAI_RHISN 167 0 -
EIHVLGDTKSVVLSMPIN LUXI_VIBFI 167 2 -
PVTVHQNEKILAIKLSAH PHZI_PSEAR 156 0 -
PVTVHQNEKILAIKLSAH Q9R9G9 156 0 -
SVIDHQNEKILAIKLSAH PHZI_PSEFL 156 0 -
QAVDLGAVRGVGIRFHLD ASAI_AERSA 166 2 -
QAVDLGAVRGVGIRFHLD AHYI_AERHY 166 2 -
PPQKVKGETLVAISFPAY RHLI_PSEAE 159 0 -
KVHLLGSTRSVALHIPMN VANI_VIBAN 167 2 -
EAFVSEKERIYLLRLPVD YUKI_YERRU 163 0 -
QGLSEKEERVYLVFLPVD CARI_ERWCA 163 0 -
QGLSEKKERVYLVFLPVD O30345 163 0 -
QGLSEKQERIYLLHLPTD ECHI_ERWCH 163 0 -
QGLSEKQEKIYLLHLPTD EXPI_ERWCH 163 0 -
EAHITEKERIYLLHLPID O85823 163 0 -
EGFVSENEPIYLLRLPID EAGI_ENTAG 163 0 -
QGESEKNEVIYLLHLSID Q9RH44 163 0 -
QGESEKNEVIYLLHLSID Q9XDD0 163 0 -
QGMSEKHERVYLLFLPVD EXPI_ERWCA 163 0 -
QGESEKNEVIYLLHLGID YENI_YEREN 163 0 -
TGCSEKNKNIYLIYMPID SWRI_SERLI 164 0 -
KGLSEKHQNIYLIHMPVD Q9L3I9 163 0 -