| Literature References | 1. BLUM, M., GRANT, D.M., MCBRIDE, W., HEIM, M. AND MEYER, U.A.
Human arylamine N-acetyltransferase genes: isolation, chromosomal
localization, and functional expression.
DNA CELL BIOL. 9 193-203 (1990).
2. VATSIS, K.P., MARTELL, K.J. AND WEBER, W.W.
Diverse point mutations in the human gene for polymorphic N-acetyltransferase.
PROC.NATL.ACAD.SCI.U.S.A. 88 6333-6337 (1991).
3. LIN, H.J., HAN, C.Y., LIN, B.K. AND HARDY, S.
Ethnic distribution of slow acetylator mutations in the polymorphic
N-acetyltransferase (NAT2) gene.
PHARMACOGENETICS 4 125-134 (1994).
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| Documentation | N-acetylation by hepatic arylamine N-acetyltransferase (NAT) is a major
route in the metabolism and detoxification of various drugs and foreign
chemicals [1]. NAT catalyses the reaction:
Acetyl-coA + arylamine = coA + N-acetylarylamine
NAT is the target of a common genetic polymorphism of clinical relevance in
humans [1]. The N-acetylation polymorphism is determined by low or high NAT
activity in liver [2]. NAT has been implicated in the action and toxicity
of amine-containing drugs, and in the susceptibility to cancer [3] and
systematic lupus erythematosus. Two highly similar human genes for NAT,
termed NAT1 and NAT2, encode genetically invariant and variant NAT proteins,
respectively [2].
ANATRNSFRASE is a 10-element fingerprint that provides a signature for
arylamine N-acetyltransferases. The fingerprint was derived from an initial
alignment of 14 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length - motif 3 includes the active
site cysteine residue. A single iteration on SPTR39_15f was required to
reach convergence, no further sequences being identified beyond the starting
set. Two true partial matches were found: NAT_MYCSM is an arylamine
N-acetyltransferase from Mycobacterium smegmatis that matches motifs 1-4
and 7; and NAT_MYCTU is an arylamine N-acetyltransferase from Mycobacterium
tuberculosis that matches motifs 1 and 2.
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| Sequence Titles | ARY1_CHICK ARYLAMINE N-ACETYLTRANSFERASE, PINEAL GLAND ISOZYME NAT-10 (EC 2.3.1.5) (ARYLAMINE ACETYLASE) - Gallus gallus (Chicken).
ARY1_HUMAN ARYLAMINE N-ACETYLTRANSFERASE 1 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 1) (ARYLAMINE N-ACETYLTRANSFERASE, MONOMORPHIC) (MNAT) (N- ACETYLTRANSFERASE TYPE 1) (NAT-1) - Homo sapiens (Human).
ARY1_MESAU ARYLAMINE N-ACETYLTRANSFERASE 1 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 1) (ARYLAMINE N-ACETYLTRANSFERASE, MONOMORPHIC) (MNAT) (N- ACETYLTRANSFERASE TYPE 1) (NAT-1) (AT-1) - Mesocricetus auratus (Golden hamster).
ARY1_MOUSE ARYLAMINE N-ACETYLTRANSFERASE 1 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 1) (N-ACETYLTRANSFERASE TYPE 1) (NAT-1) - Mus musculus (Mouse).
ARY1_RABIT ARYLAMINE N-ACETYLTRANSFERASE 1 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 1) (ARYLAMINE N-ACETYLTRANSFERASE, MONOMORPHIC) (MNAT) (N- ACETYLTRANSFERASE TYPE 1) (NAT-1) - Oryctolagus cuniculus (Rabbit).
ARY1_RAT ARYLAMINE N-ACETYLTRANSFERASE 1 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 1) (N-ACETYLTRANSFERASE TYPE 1) (NAT-1) (AT-1) - Rattus norvegicus (Rat).
ARY2_CHICK ARYLAMINE N-ACETYLTRANSFERASE, PINEAL GLAND ISOZYME NAT-3 (EC 2.3.1.5) (ARYLAMINE ACETYLASE) - Gallus gallus (Chicken).
ARY2_HUMAN ARYLAMINE N-ACETYLTRANSFERASE 2 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 2) (ARYLAMINE N-ACETYLTRANSFERASE, POLYMORPHIC) (PNAT) (N- ACETYLTRANSFERASE TYPE 2) (NAT-2) - Homo sapiens (Human).
ARY2_MESAU ARYLAMINE N-ACETYLTRANSFERASE 2 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 2) (ARYLAMINE N-ACETYLTRANSFERASE, POLYMORPHIC) (PNAT) (N- ACETYLTRANSFERASE TYPE 2) (NAT-2) (AT-2) - Mesocricetus auratus (Golden hamster).
ARY2_MOUSE ARYLAMINE N-ACETYLTRANSFERASE 2 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 2) (N-ACETYLTRANSFERASE TYPE 2) (NAT-2) - Mus musculus (Mouse).
ARY2_RABIT ARYLAMINE N-ACETYLTRANSFERASE 2 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 2) (ARYLAMINE N-ACETYLTRANSFERASE, POLYMORPHIC) (PNAT) (N- ACETYLTRANSFERASE TYPE 2) (NAT-2) - Oryctolagus cuniculus (Rabbit).
ARY2_RAT ARYLAMINE N-ACETYLTRANSFERASE 2 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 2) (N-ACETYLTRANSFERASE TYPE 2) (NAT-2) (AT-2) - Rattus norvegicus (Rat).
ARY3_MOUSE ARYLAMINE N-ACETYLTRANSFERASE 3 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 3) (N-ACETYLTRANSFERASE TYPE 3) (NAT-3) - Mus musculus (Mouse).
ARYL_CHICK ARYLAMINE N-ACETYLTRANSFERASE, LIVER ISOZYME (EC 2.3.1.5) (ARYLAMINE ACETYLASE) - Gallus gallus (Chicken).
NAT_MYCSM ARYLAMINE N-ACETYLTRANSFERASE (EC 2.3.1.5) - Mycobacterium smegmatis.
NAT_MYCTU ARYLAMINE N-ACETYLTRANSFERASE (EC 2.3.1.5) - Mycobacterium tuberculosis.
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