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PR01543

Identifier
ANATRNSFRASE  [View Relations]  [View Alignment]  
Accession
PR01543
No. of Motifs
10
Creation Date
10-APR-2001
Title
Arylamine N-acetyltransferase signature
Database References

PFAM; PF00797 Acetyltransf2
INTERPRO; IPR001447 Acety
UMBBD; e0341
MIM; 243400
Literature References
1. BLUM, M., GRANT, D.M., MCBRIDE, W., HEIM, M. AND MEYER, U.A.
Human arylamine N-acetyltransferase genes: isolation, chromosomal 
localization, and functional expression.
DNA CELL BIOL. 9 193-203 (1990). 
 
2. VATSIS, K.P., MARTELL, K.J. AND WEBER, W.W.
Diverse point mutations in the human gene for polymorphic N-acetyltransferase.
PROC.NATL.ACAD.SCI.U.S.A. 88 6333-6337 (1991).
 
3. LIN, H.J., HAN, C.Y., LIN, B.K. AND HARDY, S.
Ethnic distribution of slow acetylator mutations in the polymorphic
N-acetyltransferase (NAT2) gene.
PHARMACOGENETICS 4 125-134 (1994). 

Documentation
N-acetylation by hepatic arylamine N-acetyltransferase (NAT) is a major 
route in the metabolism and detoxification of various drugs and foreign 
chemicals [1]. NAT catalyses the reaction:
 
           Acetyl-coA + arylamine = coA + N-acetylarylamine
 
NAT is the target of a common genetic polymorphism of clinical relevance in
humans [1]. The N-acetylation polymorphism is determined by low or high NAT
activity in liver [2]. NAT has been implicated in the action and toxicity 
of amine-containing drugs, and in the susceptibility to cancer [3] and
systematic lupus erythematosus. Two highly similar human genes for NAT, 
termed NAT1 and NAT2, encode genetically invariant and variant NAT proteins,
respectively [2].
 
ANATRNSFRASE is a 10-element fingerprint that provides a signature for 
arylamine N-acetyltransferases. The fingerprint was derived from an initial
alignment of 14 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length - motif 3 includes the active
site cysteine residue. A single iteration on SPTR39_15f was required to
reach convergence, no further sequences being identified beyond the starting
set. Two true partial matches were found: NAT_MYCSM is an arylamine
N-acetyltransferase from Mycobacterium smegmatis that matches motifs 1-4
and 7; and NAT_MYCTU is an arylamine N-acetyltransferase from Mycobacterium
tuberculosis that matches motifs 1 and 2.
Summary Information
  14 codes involving 10 elements
0 codes involving 9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
1 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
1014141414141414141414
90000000000
80000000000
70000000000
60000000000
51111001000
40000000000
30000000000
21100000000
12345678910
True Positives
ARY1_CHICK    ARY1_HUMAN    ARY1_MESAU    ARY1_MOUSE    
ARY1_RABIT ARY1_RAT ARY2_CHICK ARY2_HUMAN
ARY2_MESAU ARY2_MOUSE ARY2_RABIT ARY2_RAT
ARY3_MOUSE ARYL_CHICK
True Positive Partials
Codes involving 5 elements
NAT_MYCSM
Codes involving 2 elements
NAT_MYCTU
Sequence Titles
ARY1_CHICK  ARYLAMINE N-ACETYLTRANSFERASE, PINEAL GLAND ISOZYME NAT-10 (EC 2.3.1.5) (ARYLAMINE ACETYLASE) - Gallus gallus (Chicken). 
ARY1_HUMAN ARYLAMINE N-ACETYLTRANSFERASE 1 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 1) (ARYLAMINE N-ACETYLTRANSFERASE, MONOMORPHIC) (MNAT) (N- ACETYLTRANSFERASE TYPE 1) (NAT-1) - Homo sapiens (Human).
ARY1_MESAU ARYLAMINE N-ACETYLTRANSFERASE 1 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 1) (ARYLAMINE N-ACETYLTRANSFERASE, MONOMORPHIC) (MNAT) (N- ACETYLTRANSFERASE TYPE 1) (NAT-1) (AT-1) - Mesocricetus auratus (Golden hamster).
ARY1_MOUSE ARYLAMINE N-ACETYLTRANSFERASE 1 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 1) (N-ACETYLTRANSFERASE TYPE 1) (NAT-1) - Mus musculus (Mouse).
ARY1_RABIT ARYLAMINE N-ACETYLTRANSFERASE 1 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 1) (ARYLAMINE N-ACETYLTRANSFERASE, MONOMORPHIC) (MNAT) (N- ACETYLTRANSFERASE TYPE 1) (NAT-1) - Oryctolagus cuniculus (Rabbit).
ARY1_RAT ARYLAMINE N-ACETYLTRANSFERASE 1 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 1) (N-ACETYLTRANSFERASE TYPE 1) (NAT-1) (AT-1) - Rattus norvegicus (Rat).
ARY2_CHICK ARYLAMINE N-ACETYLTRANSFERASE, PINEAL GLAND ISOZYME NAT-3 (EC 2.3.1.5) (ARYLAMINE ACETYLASE) - Gallus gallus (Chicken).
ARY2_HUMAN ARYLAMINE N-ACETYLTRANSFERASE 2 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 2) (ARYLAMINE N-ACETYLTRANSFERASE, POLYMORPHIC) (PNAT) (N- ACETYLTRANSFERASE TYPE 2) (NAT-2) - Homo sapiens (Human).
ARY2_MESAU ARYLAMINE N-ACETYLTRANSFERASE 2 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 2) (ARYLAMINE N-ACETYLTRANSFERASE, POLYMORPHIC) (PNAT) (N- ACETYLTRANSFERASE TYPE 2) (NAT-2) (AT-2) - Mesocricetus auratus (Golden hamster).
ARY2_MOUSE ARYLAMINE N-ACETYLTRANSFERASE 2 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 2) (N-ACETYLTRANSFERASE TYPE 2) (NAT-2) - Mus musculus (Mouse).
ARY2_RABIT ARYLAMINE N-ACETYLTRANSFERASE 2 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 2) (ARYLAMINE N-ACETYLTRANSFERASE, POLYMORPHIC) (PNAT) (N- ACETYLTRANSFERASE TYPE 2) (NAT-2) - Oryctolagus cuniculus (Rabbit).
ARY2_RAT ARYLAMINE N-ACETYLTRANSFERASE 2 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 2) (N-ACETYLTRANSFERASE TYPE 2) (NAT-2) (AT-2) - Rattus norvegicus (Rat).
ARY3_MOUSE ARYLAMINE N-ACETYLTRANSFERASE 3 (EC 2.3.1.5) (ARYLAMIDE ACETYLASE 3) (N-ACETYLTRANSFERASE TYPE 3) (NAT-3) - Mus musculus (Mouse).
ARYL_CHICK ARYLAMINE N-ACETYLTRANSFERASE, LIVER ISOZYME (EC 2.3.1.5) (ARYLAMINE ACETYLASE) - Gallus gallus (Chicken).

NAT_MYCSM ARYLAMINE N-ACETYLTRANSFERASE (EC 2.3.1.5) - Mycobacterium smegmatis.

NAT_MYCTU ARYLAMINE N-ACETYLTRANSFERASE (EC 2.3.1.5) - Mycobacterium tuberculosis.
Scan History
SPTR39_15f 1  80   NSINGLE    
Initial Motifs
Motif 1  width=24
Element Seqn Id St Int Rpt
DLQTLTEILQHQIRAIPFENLNIH ARY2_MESAU 20 20 -
DLKTLTEILQHQIRAIPFENLNIH ARY2_MOUSE 20 20 -
DLEELTEILQHQIRAIPFENLNIH ARY2_RAT 20 20 -
DLATLTEVLQHQMRAVPFENLSMH ARY1_RAT 20 20 -
DLETLTDILQHQIRAVPFENLNIH ARY1_HUMAN 20 20 -
DLATLTEVLQHQMRAVPFENLNMH ARY1_MOUSE 20 20 -
DLATLTEVLQHQMRTIPFENLNMH ARY1_MESAU 20 20 -
DLESLTDIFQHQIRTVPYENLSIH ARY2_RABIT 20 20 -
DLESLTDIFQHQIRTVPYENLSIH ARY1_RABIT 20 20 -
DLETLTDILEHQIRAVPFENLNMH ARY2_HUMAN 20 20 -
DLQTLTEILQHQIRAIPFENLNIH ARY3_MOUSE 20 20 -
DLETLTDIFQHHIRAVPFENLSIH ARY1_CHICK 20 20 -
DLETLTEIFQHHIQAVPFENLSIH ARY2_CHICK 20 20 -
DLQTLTAIFQHHIQAIPFENLSMH ARYL_CHICK 20 20 -

Motif 2 width=24
Element Seqn Id St Int Rpt
CGESMELSLETIFDQIVRKKRGGW ARY2_MESAU 44 0 -
CGESMELSLEAIFDQIVRKKRGGW ARY2_MOUSE 44 0 -
CGESMELNLEVIFDQVVRKKRGGW ARY2_RAT 44 0 -
CGEAMCLGLEATFDHIVRKKRGGW ARY1_RAT 44 0 -
CGDAMDLGLEAIFDQVVRRNRGGW ARY1_HUMAN 44 0 -
CGEAMHLDLQDIFDHIVRKKRGGW ARY1_MOUSE 44 0 -
CGEAMDLGLEATFDQIVRKKRGGW ARY1_MESAU 44 0 -
CGESMELDLEAIFDQIVRRNRGGW ARY2_RABIT 44 0 -
CGESMELDLEAIFDQIVRRNRGGW ARY1_RABIT 44 0 -
CGQAMELGLEAIFDHIVRRNRGGW ARY2_HUMAN 44 0 -
CGKTMELSLEDTFHQIVRKKRGGW ARY3_MOUSE 44 0 -
CGEKITLELEHVYNKIVHKKRGGW ARY1_CHICK 44 0 -
CGETIELDLAATYDKIVRKKRGGW ARY2_CHICK 44 0 -
CGETIDLDLQATYNKIVKKKRGGW ARYL_CHICK 44 0 -

Motif 3 width=23
Element Seqn Id St Int Rpt
CLQVNHLLYWALTKMGFETTMLG ARY2_MESAU 68 0 -
CLQVNHLLYWALTKLGFETTMLG ARY2_MOUSE 68 0 -
CLQVNHLLYWALTKMGFEATMLG ARY2_RAT 68 0 -
CLQVNHLLYWALTKMGFETTMLG ARY1_RAT 68 0 -
CLQVNHLLYWALTTIGFETTMLG ARY1_HUMAN 68 0 -
CLQVNHLLYWALTKMGFETTMLG ARY1_MOUSE 68 0 -
CLQVNHLLYWALTQMGFETTMLG ARY1_MESAU 68 0 -
CLQVNYLLYWALTTTGFETTMLG ARY2_RABIT 68 0 -
CLQVNYLLYWALTTTGFETTMLG ARY1_RABIT 68 0 -
CLQVNQLLYWALTTIGFQTTMLG ARY2_HUMAN 68 0 -
CLQVNHLLYWALAMIGFETTMLG ARY3_MOUSE 68 0 -
CMENNQLLGWVLKCLGYDTSFLG ARY1_CHICK 68 0 -
CMENNHLLSWALKTLGYNVTLLG ARY2_CHICK 68 0 -
CMETNYLLFWALKEMGYDICVLG ARYL_CHICK 68 0 -

Motif 4 width=26
Element Seqn Id St Int Rpt
YSSGMIHLLVQVTISDRNYIVDAGFG ARY2_MESAU 101 10 -
YSSGMIHLLVQVTISGKDYIVDAGFG ARY2_MOUSE 101 10 -
YSSGMIHLLVQVTLSGKDYIVDAGFG ARY2_RAT 101 10 -
YSSEMVHLLVQVTISDRNYIVDSAYG ARY1_RAT 101 10 -
YSTGMIHLLLQVTIDGRNYIVDAGFG ARY1_HUMAN 101 10 -
YSSEMVHLLVQVTISDRKYIVDSAYG ARY1_MOUSE 101 10 -
YSSEMIHLLVQVTISDRNYIVDAAYG ARY1_MESAU 101 10 -
YSTGMIHLIVQVTINGRNYIVDAGFG ARY2_RABIT 101 10 -
YSTGMIHLIVQVTINGRNYIVDAGFG ARY1_RABIT 101 10 -
YSTGMVHLLLQVTIDGRNYIVDAGSG ARY2_HUMAN 101 10 -
YSNTMIHLLLQVTISGKTYIVDSAFP ARY3_MOUSE 101 10 -
YATIMTHLLVKVVIEGKAYIVDAGFG ARY1_CHICK 101 10 -
YADDIDHLLLKVVLHDKSYIVDGGFG ARY2_CHICK 101 10 -
YTDEINHILLKVVIKGSSYIVDAGFG ARYL_CHICK 101 10 -

Motif 5 width=21
Element Seqn Id St Int Rpt
QMWEPLELVSGKDHPQVPAIF ARY2_MESAU 130 3 -
QMWEPLELTSGKDQPQVPAIF ARY2_MOUSE 130 3 -
QMWEPLELTSGKDQPQVPAIF ARY2_RAT 130 3 -
QMWEPLELTSGKDQPQVPAIF ARY1_RAT 130 3 -
QMWQPLELISGKDQPQVPCVF ARY1_HUMAN 130 3 -
QMWEPLELTSGKDQPQVPAIF ARY1_MOUSE 130 3 -
QMWEPVELASGKDQPQVPAIF ARY1_MESAU 130 3 -
QMWQPVELISGKDQPQVPSIF ARY2_RABIT 130 3 -
QMWQPVELISGKDQPQVPSIF ARY1_RABIT 130 3 -
QMWQPLELISGKDQPQVPCIF ARY2_HUMAN 130 3 -
QLWEPLELTSGKDQPQVPAIF ARY3_MOUSE 130 3 -
QMWQPMELVSGKDQPQAPGIF ARY1_CHICK 130 3 -
QLWQPMELISGKDQPQTPGIF ARY2_CHICK 130 3 -
QTWLPMLLISGKDQPQIPGIF ARYL_CHICK 131 4 -

Motif 6 width=20
Element Seqn Id St Int Rpt
LTEENETWYLDQIRREQYVP ARY2_MESAU 152 1 -
LTEENGTWYLDQIRREQYVP ARY2_MOUSE 152 1 -
LTEENGTWYLDQIRREQYVP ARY2_RAT 152 1 -
LTEENGTWYLDQIRREQDVP ARY1_RAT 152 1 -
LTEENGFWYLDQIRREQYIP ARY1_HUMAN 152 1 -
LTEENGTWYLDQIRREQYVP ARY1_MOUSE 152 1 -
LTEENETWYLDQIRREQHVP ARY1_MESAU 152 1 -
LREEGETWYLDQIRRQQHVP ARY2_RABIT 152 1 -
LREEGETWYLDQIRRQQHVP ARY1_RABIT 152 1 -
LTEERGIWYLDQIRREQYIT ARY2_HUMAN 152 1 -
LREENGTWYLEQTKRQEYVS ARY3_MOUSE 152 1 -
FTEKNAIWYLEKMRRKQYIP ARY1_CHICK 152 1 -
FVEENGTWYLEKVKRKQYVP ARY2_CHICK 152 1 -
FIEDNGIWYLEKVKRKHYVP ARYL_CHICK 153 1 -

Motif 7 width=23
Element Seqn Id St Int Rpt
KIYSFTLEPRTIEDFESMNTYLQ ARY2_MESAU 188 16 -
KIYSFTLEPRTIEDFESMNTYLQ ARY2_MOUSE 188 16 -
KIYSFTLEPRTIEDFESINTYLQ ARY2_RAT 188 16 -
KIYSFTLEPRTIEDFEYVNTYLQ ARY1_RAT 188 16 -
KIYSFTLKPRTIEDFESMNTYLQ ARY1_HUMAN 188 16 -
KIYSFTLEPRVIEDFEYVNSYLQ ARY1_MOUSE 188 16 -
KIYSFTLQPRTIEDFEYANTYLQ ARY1_MESAU 188 16 -
KLYCFTLQPRTIEEFESANTYLQ ARY2_RABIT 188 16 -
KLYCFTLQPRTIEEFESANTYLQ ARY1_RABIT 188 16 -
KIYLFTLEPRTIEDFESMNTYLQ ARY2_HUMAN 188 16 -
KIYSFTLEPRTIEDFWSISTYYQ ARY3_MOUSE 188 16 -
KVYMFSLEPRTVEDFCFQCTYLQ ARY1_CHICK 188 16 -
RVYLFTLQPRDIEEFRARNLHLQ ARY2_CHICK 188 16 -
KLYSFTLEPKHIDDFQELNAYLQ ARYL_CHICK 189 16 -

Motif 8 width=24
Element Seqn Id St Int Rpt
CSLQTPEGVHCLVGCTLTYRRFSY ARY2_MESAU 223 12 -
CSLQTPEGVHCLVGSTLTYRRFSY ARY2_MOUSE 223 12 -
CSLQTLEGVHCLVGSTLTYRRFSY ARY2_RAT 223 12 -
CSLQTSEGVCCLIGSTLTSRRFSY ARY1_RAT 223 12 -
CSLQTPDGVHCLVGFTLTHRRFNY ARY1_HUMAN 223 12 -
CSLQTSEGVHCLVGSTFTSRRFSY ARY1_MOUSE 223 12 -
CSLQTSEGVCCLIGSTIARRKFSY ARY1_MESAU 223 12 -
CSLQTPEGVHCLVGLTLTSRTYNY ARY2_RABIT 223 12 -
CSLQTPEGVHCLVGLILTFRTYNY ARY1_RABIT 223 12 -
CSLQTPEGVYCLVGFILTYRKFNY ARY2_HUMAN 223 12 -
CSLHTKDGVHGLMGTILAYKKFNY ARY3_MOUSE 223 12 -
CTLQTTDGFRALIGWTLTETKYNY ARY1_CHICK 223 12 -
CSLQTPDGVRALVGWKLTEIKYNY ARY2_CHICK 223 12 -
CSLQTTDGFYALVGWTFSEMKYKY ARYL_CHICK 224 12 -

Motif 9 width=22
Element Seqn Id St Int Rpt
KDNVDLVEFKSLKEEEIEDVLK ARY2_MESAU 247 0 -
KDNVDLVEFKSLTEEEIEDVLR ARY2_MOUSE 247 0 -
KDNIDLVEFKSLTEEEIEDVLK ARY2_RAT 247 0 -
KDNVDLVEFKSLTEEEIEDVLK ARY1_RAT 247 0 -
KDNTDLIEFKTLSEEEIEKVLK ARY1_HUMAN 247 0 -
KDDVDLVEFKYVNEEEIEDVLK ARY1_MOUSE 247 0 -
KENVDLVEFKNVSEEEIEDVLK ARY1_MESAU 247 0 -
KENTDLVEFKVLTEEEVEGVLK ARY2_RABIT 247 0 -
KENTDLVEFKVLTEEEVEEVLK ARY1_RABIT 247 0 -
KDNTDLVEFKTLTEEEVEEVLK ARY2_HUMAN 247 0 -
KDNIDLVEFKTLKEEEIEEVLK ARY3_MOUSE 247 0 -
KENMDLVEFITLKDEEVEKTLK ARY1_CHICK 247 0 -
KDNMDLVEIRILADEEMEKTLK ARY2_CHICK 247 0 -
KEDADLLQTTTLTDEEVEKTLK ARYL_CHICK 248 0 -

Motif 10 width=14
Element Seqn Id St Int Rpt
KTIFGISLEKKLVP ARY2_MESAU 268 -1 -
RTIFGVSLERKLVP ARY2_MOUSE 268 -1 -
KTIFGVSLERKLVP ARY2_RAT 268 -1 -
KTTFGISLEKKFVP ARY1_RAT 268 -1 -
KNIFNISLQRKLVP ARY1_HUMAN 268 -1 -
KTAFGISLERKFVP ARY1_MOUSE 268 -1 -
KTAFGVSLERKFVP ARY1_MESAU 268 -1 -
KTIFNISLGKKLVS ARY2_RABIT 268 -1 -
KTIFNISLGKKLVS ARY1_RABIT 268 -1 -
KNIFKISLGRNLVP ARY2_HUMAN 268 -1 -
KSVFGIHLETKLVP ARY3_MOUSE 268 -1 -
KDKFNITLERKLVP ARY1_CHICK 268 -1 -
KEKFNITLDKKFVP ARY2_CHICK 268 -1 -
KDKFNIVLENKLIP ARYL_CHICK 269 -1 -
Final Motifs
Motif 1  width=24
Element Seqn Id St Int Rpt
DLQTLTEILQHQIRAIPFENLNIH ARY2_MESAU 20 20 -
DLKTLTEILQHQIRAIPFENLNIH ARY2_MOUSE 20 20 -
DLEELTEILQHQIRAIPFENLNIH ARY2_RAT 20 20 -
DLATLTEVLQHQMRAVPFENLSMH ARY1_RAT 20 20 -
DLETLTDILQHQIRAVPFENLNIH ARY1_HUMAN 20 20 -
DLATLTEVLQHQMRAVPFENLNMH ARY1_MOUSE 20 20 -
DLATLTEVLQHQMRTIPFENLNMH ARY1_MESAU 20 20 -
DLESLTDIFQHQIRTVPYENLSIH ARY2_RABIT 20 20 -
DLESLTDIFQHQIRTVPYENLSIH ARY1_RABIT 20 20 -
DLETLTDILEHQIRAVPFENLNMH ARY2_HUMAN 20 20 -
DLQTLTEILQHQIRAIPFENLNIH ARY3_MOUSE 20 20 -
DLETLTDIFQHHIRAVPFENLSIH ARY1_CHICK 20 20 -
DLETLTEIFQHHIQAVPFENLSIH ARY2_CHICK 20 20 -
DLQTLTAIFQHHIQAIPFENLSMH ARYL_CHICK 20 20 -

Motif 2 width=24
Element Seqn Id St Int Rpt
CGESMELSLETIFDQIVRKKRGGW ARY2_MESAU 44 0 -
CGESMELSLEAIFDQIVRKKRGGW ARY2_MOUSE 44 0 -
CGESMELNLEVIFDQVVRKKRGGW ARY2_RAT 44 0 -
CGEAMCLGLEATFDHIVRKKRGGW ARY1_RAT 44 0 -
CGDAMDLGLEAIFDQVVRRNRGGW ARY1_HUMAN 44 0 -
CGEAMHLDLQDIFDHIVRKKRGGW ARY1_MOUSE 44 0 -
CGEAMDLGLEATFDQIVRKKRGGW ARY1_MESAU 44 0 -
CGESMELDLEAIFDQIVRRNRGGW ARY2_RABIT 44 0 -
CGESMELDLEAIFDQIVRRNRGGW ARY1_RABIT 44 0 -
CGQAMELGLEAIFDHIVRRNRGGW ARY2_HUMAN 44 0 -
CGKTMELSLEDTFHQIVRKKRGGW ARY3_MOUSE 44 0 -
CGEKITLELEHVYNKIVHKKRGGW ARY1_CHICK 44 0 -
CGETIELDLAATYDKIVRKKRGGW ARY2_CHICK 44 0 -
CGETIDLDLQATYNKIVKKKRGGW ARYL_CHICK 44 0 -

Motif 3 width=23
Element Seqn Id St Int Rpt
CLQVNHLLYWALTKMGFETTMLG ARY2_MESAU 68 0 -
CLQVNHLLYWALTKLGFETTMLG ARY2_MOUSE 68 0 -
CLQVNHLLYWALTKMGFEATMLG ARY2_RAT 68 0 -
CLQVNHLLYWALTKMGFETTMLG ARY1_RAT 68 0 -
CLQVNHLLYWALTTIGFETTMLG ARY1_HUMAN 68 0 -
CLQVNHLLYWALTKMGFETTMLG ARY1_MOUSE 68 0 -
CLQVNHLLYWALTQMGFETTMLG ARY1_MESAU 68 0 -
CLQVNYLLYWALTTTGFETTMLG ARY2_RABIT 68 0 -
CLQVNYLLYWALTTTGFETTMLG ARY1_RABIT 68 0 -
CLQVNQLLYWALTTIGFQTTMLG ARY2_HUMAN 68 0 -
CLQVNHLLYWALAMIGFETTMLG ARY3_MOUSE 68 0 -
CMENNQLLGWVLKCLGYDTSFLG ARY1_CHICK 68 0 -
CMENNHLLSWALKTLGYNVTLLG ARY2_CHICK 68 0 -
CMETNYLLFWALKEMGYDICVLG ARYL_CHICK 68 0 -

Motif 4 width=26
Element Seqn Id St Int Rpt
YSSGMIHLLVQVTISDRNYIVDAGFG ARY2_MESAU 101 10 -
YSSGMIHLLVQVTISGKDYIVDAGFG ARY2_MOUSE 101 10 -
YSSGMIHLLVQVTLSGKDYIVDAGFG ARY2_RAT 101 10 -
YSSEMVHLLVQVTISDRNYIVDSAYG ARY1_RAT 101 10 -
YSTGMIHLLLQVTIDGRNYIVDAGFG ARY1_HUMAN 101 10 -
YSSEMVHLLVQVTISDRKYIVDSAYG ARY1_MOUSE 101 10 -
YSSEMIHLLVQVTISDRNYIVDAAYG ARY1_MESAU 101 10 -
YSTGMIHLIVQVTINGRNYIVDAGFG ARY2_RABIT 101 10 -
YSTGMIHLIVQVTINGRNYIVDAGFG ARY1_RABIT 101 10 -
YSTGMVHLLLQVTIDGRNYIVDAGSG ARY2_HUMAN 101 10 -
YSNTMIHLLLQVTISGKTYIVDSAFP ARY3_MOUSE 101 10 -
YATIMTHLLVKVVIEGKAYIVDAGFG ARY1_CHICK 101 10 -
YADDIDHLLLKVVLHDKSYIVDGGFG ARY2_CHICK 101 10 -
YTDEINHILLKVVIKGSSYIVDAGFG ARYL_CHICK 101 10 -

Motif 5 width=21
Element Seqn Id St Int Rpt
QMWEPLELVSGKDHPQVPAIF ARY2_MESAU 130 3 -
QMWEPLELTSGKDQPQVPAIF ARY2_MOUSE 130 3 -
QMWEPLELTSGKDQPQVPAIF ARY2_RAT 130 3 -
QMWEPLELTSGKDQPQVPAIF ARY1_RAT 130 3 -
QMWQPLELISGKDQPQVPCVF ARY1_HUMAN 130 3 -
QMWEPLELTSGKDQPQVPAIF ARY1_MOUSE 130 3 -
QMWEPVELASGKDQPQVPAIF ARY1_MESAU 130 3 -
QMWQPVELISGKDQPQVPSIF ARY2_RABIT 130 3 -
QMWQPVELISGKDQPQVPSIF ARY1_RABIT 130 3 -
QMWQPLELISGKDQPQVPCIF ARY2_HUMAN 130 3 -
QLWEPLELTSGKDQPQVPAIF ARY3_MOUSE 130 3 -
QMWQPMELVSGKDQPQAPGIF ARY1_CHICK 130 3 -
QLWQPMELISGKDQPQTPGIF ARY2_CHICK 130 3 -
QTWLPMLLISGKDQPQIPGIF ARYL_CHICK 131 4 -

Motif 6 width=20
Element Seqn Id St Int Rpt
LTEENETWYLDQIRREQYVP ARY2_MESAU 152 1 -
LTEENGTWYLDQIRREQYVP ARY2_MOUSE 152 1 -
LTEENGTWYLDQIRREQYVP ARY2_RAT 152 1 -
LTEENGTWYLDQIRREQDVP ARY1_RAT 152 1 -
LTEENGFWYLDQIRREQYIP ARY1_HUMAN 152 1 -
LTEENGTWYLDQIRREQYVP ARY1_MOUSE 152 1 -
LTEENETWYLDQIRREQHVP ARY1_MESAU 152 1 -
LREEGETWYLDQIRRQQHVP ARY2_RABIT 152 1 -
LREEGETWYLDQIRRQQHVP ARY1_RABIT 152 1 -
LTEERGIWYLDQIRREQYIT ARY2_HUMAN 152 1 -
LREENGTWYLEQTKRQEYVS ARY3_MOUSE 152 1 -
FTEKNAIWYLEKMRRKQYIP ARY1_CHICK 152 1 -
FVEENGTWYLEKVKRKQYVP ARY2_CHICK 152 1 -
FIEDNGIWYLEKVKRKHYVP ARYL_CHICK 153 1 -

Motif 7 width=23
Element Seqn Id St Int Rpt
KIYSFTLEPRTIEDFESMNTYLQ ARY2_MESAU 188 16 -
KIYSFTLEPRTIEDFESMNTYLQ ARY2_MOUSE 188 16 -
KIYSFTLEPRTIEDFESINTYLQ ARY2_RAT 188 16 -
KIYSFTLEPRTIEDFEYVNTYLQ ARY1_RAT 188 16 -
KIYSFTLKPRTIEDFESMNTYLQ ARY1_HUMAN 188 16 -
KIYSFTLEPRVIEDFEYVNSYLQ ARY1_MOUSE 188 16 -
KIYSFTLQPRTIEDFEYANTYLQ ARY1_MESAU 188 16 -
KLYCFTLQPRTIEEFESANTYLQ ARY2_RABIT 188 16 -
KLYCFTLQPRTIEEFESANTYLQ ARY1_RABIT 188 16 -
KIYLFTLEPRTIEDFESMNTYLQ ARY2_HUMAN 188 16 -
KIYSFTLEPRTIEDFWSISTYYQ ARY3_MOUSE 188 16 -
KVYMFSLEPRTVEDFCFQCTYLQ ARY1_CHICK 188 16 -
RVYLFTLQPRDIEEFRARNLHLQ ARY2_CHICK 188 16 -
KLYSFTLEPKHIDDFQELNAYLQ ARYL_CHICK 189 16 -

Motif 8 width=24
Element Seqn Id St Int Rpt
CSLQTPEGVHCLVGCTLTYRRFSY ARY2_MESAU 223 12 -
CSLQTPEGVHCLVGSTLTYRRFSY ARY2_MOUSE 223 12 -
CSLQTLEGVHCLVGSTLTYRRFSY ARY2_RAT 223 12 -
CSLQTSEGVCCLIGSTLTSRRFSY ARY1_RAT 223 12 -
CSLQTPDGVHCLVGFTLTHRRFNY ARY1_HUMAN 223 12 -
CSLQTSEGVHCLVGSTFTSRRFSY ARY1_MOUSE 223 12 -
CSLQTSEGVCCLIGSTIARRKFSY ARY1_MESAU 223 12 -
CSLQTPEGVHCLVGLTLTSRTYNY ARY2_RABIT 223 12 -
CSLQTPEGVHCLVGLILTFRTYNY ARY1_RABIT 223 12 -
CSLQTPEGVYCLVGFILTYRKFNY ARY2_HUMAN 223 12 -
CSLHTKDGVHGLMGTILAYKKFNY ARY3_MOUSE 223 12 -
CTLQTTDGFRALIGWTLTETKYNY ARY1_CHICK 223 12 -
CSLQTPDGVRALVGWKLTEIKYNY ARY2_CHICK 223 12 -
CSLQTTDGFYALVGWTFSEMKYKY ARYL_CHICK 224 12 -

Motif 9 width=22
Element Seqn Id St Int Rpt
KDNVDLVEFKSLKEEEIEDVLK ARY2_MESAU 247 0 -
KDNVDLVEFKSLTEEEIEDVLR ARY2_MOUSE 247 0 -
KDNIDLVEFKSLTEEEIEDVLK ARY2_RAT 247 0 -
KDNVDLVEFKSLTEEEIEDVLK ARY1_RAT 247 0 -
KDNTDLIEFKTLSEEEIEKVLK ARY1_HUMAN 247 0 -
KDDVDLVEFKYVNEEEIEDVLK ARY1_MOUSE 247 0 -
KENVDLVEFKNVSEEEIEDVLK ARY1_MESAU 247 0 -
KENTDLVEFKVLTEEEVEGVLK ARY2_RABIT 247 0 -
KENTDLVEFKVLTEEEVEEVLK ARY1_RABIT 247 0 -
KDNTDLVEFKTLTEEEVEEVLK ARY2_HUMAN 247 0 -
KDNIDLVEFKTLKEEEIEEVLK ARY3_MOUSE 247 0 -
KENMDLVEFITLKDEEVEKTLK ARY1_CHICK 247 0 -
KDNMDLVEIRILADEEMEKTLK ARY2_CHICK 247 0 -
KEDADLLQTTTLTDEEVEKTLK ARYL_CHICK 248 0 -

Motif 10 width=14
Element Seqn Id St Int Rpt
KTIFGISLEKKLVP ARY2_MESAU 268 -1 -
RTIFGVSLERKLVP ARY2_MOUSE 268 -1 -
KTIFGVSLERKLVP ARY2_RAT 268 -1 -
KTTFGISLEKKFVP ARY1_RAT 268 -1 -
KNIFNISLQRKLVP ARY1_HUMAN 268 -1 -
KTAFGISLERKFVP ARY1_MOUSE 268 -1 -
KTAFGVSLERKFVP ARY1_MESAU 268 -1 -
KTIFNISLGKKLVS ARY2_RABIT 268 -1 -
KTIFNISLGKKLVS ARY1_RABIT 268 -1 -
KNIFKISLGRNLVP ARY2_HUMAN 268 -1 -
KSVFGIHLETKLVP ARY3_MOUSE 268 -1 -
KDKFNITLERKLVP ARY1_CHICK 268 -1 -
KEKFNITLDKKFVP ARY2_CHICK 268 -1 -
KDKFNIVLENKLIP ARYL_CHICK 269 -1 -