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PR01535

Identifier
VOMERONASL2R  [View Relations]  [View Alignment]  
Accession
PR01535
No. of Motifs
9
Creation Date
17-MAY-2001
Title
Vomeronasal type 2 receptor family signature
Database References
PRINTS; PR90007 7TM; PR90006 GPCRCLAN; PR00248 GPCRMGR
Literature References
1. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
 
2. MASU, M., TANABE, Y., TSUCHIDA, K., SHIGEMOTO, R. AND NAKANISHI, S.
Sequence and expression of a metabotropic glutamate receptor.
NATURE 349 760-765 (1991).
 
3. HOUAMED, K.M., KUIJPER, J.L., GILBERT, T.L., HALDEMAN, B.A., O'HARA, P.J.,
MULVIHILL, E.R., ALMERS, W. AND HAGEN, F.S.
Cloning, expression and gene structure of a G protein-coupled glutamate
receptor from rat brain.
SCIENCE 252 1318-1321 (1991).
 
4. ABE, T., SUGIHARA, H., NAWA, H., SHIGEMOTO, R., MIZUNO, N. AND 
NAKANISHI, S.
Molecular characterisation of a novel metabotropic glutamate receptor MGLUR5
coupled to inositol phosphate/Ca2+ signal transduction.
J.BIOL.CHEM. 267(19) 13361-13368 (1992).
 
5. TANABE, Y., MASU, M., ISHII, T., SHIGEMOTO, R. AND NAKANISHI, S.
A family of metabotropic glutamate receptors.
NEURON 8(1) 169-179 (1992).
 
6. BROWN, E.M., GAMBA, G., RICCARDI, D., LOMBARDI, M., BUTTERS, R.,
KIFOR, O., SUN, A., HEDIGER, M.A., LYTTON, J. AND HEBERT, S.C.
Cloning an characterisation of an extracellular Ca(2+)-sensing receptor from
bovine parathyroid.
NATURE 366 575-580 (1993).
 
7. KEVERNE, E.B.
The vomeronasal organ.
SCIENCE 286 716-720 (1999).
 
8. PANTAGES, E. AND DULAC, C.
A novel family of candidate pheromone receptors in mammals.
NEURON 28 835-845 (2000).
 
9. RYBA, N.J.P. AND TIRINDELLI, R.
A new multigene family of putative pheromone receptors.
NEURON 19(2) 371-379 (1997).
 
10. NAITO T., SAITO, Y., YAMAMOTO, J., NOZAKI, Y., TOMURA, K., HAZAMA, M.,
NAKANISHI, S. AND BRENNER, S.
Putative pheromone receptors related to the Ca2+ sensing receptor in Fugu.
PROC.NATL.ACAD.SCI.U.S.A. 95 5178-5181 (1998).
 
11. SPECA, D.J., LIN, D.M., SORENSEN, P.W., ISACOFF, E.Y., NGAI, J.
AND DITTMAN, A.H.
Functional identification of a goldfish odorant receptor.
NEURON 23(3) 487-498 (1999).

Documentation
G protein-coupled receptors (GPCRs) constitute a vast protein family that
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the
sequence level, on the basis of which they can be separated into distinct
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship,
but between which there is no statistically significant similarity in
sequence [1]. The currently known clan members include the rhodopsin-like
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
 
The metabotropic glutamate receptors are functionally and pharmacologically
distinct from the ionotropic glutamate receptors. They are coupled to
G proteins and stimulate the inositol phosphate/Ca2+ intracellular
signalling pathway [2-5]. The amino acid sequences of the receptors contain
high proportions of hydrophobic residues grouped into 7 domains, in a manner
reminiscent of the rhodopsins and other receptors believed to interact with
G proteins. However, while a similar 3D framework has been proposed to
account for this, there is no significant sequence identity between these
and receptors of the rhodopsin-type family: the metabotropic glutamate
receptors thus bear their own distinctive `7TM' signature.
 
Pheromones have evolved in all animal phyla, to signal sex and dominance
status, and are responsible for stereotypical social and sexual behaviour
among members of the same species. In mammals, these chemical signals are
believed to be detected primarily by the vomeronasal organ (VNO), a
chemosensory organ located at the base of the nasal septum [8]. The VNO is
present in most amphibia, reptiles and non-primate mammals but is absent in
birds, adult catarrhine monkeys and apes [7]. An active role for the human
VNO in the detection of pheromones is disputed; the VNO is present in the
foetus but appears to be atrophied or absent in adults [7]. Three distinct 
families of putative pheromone receptors have been identified in the 
vomeronasal organ (V1Rs, V2Rs and V3Rs). All are G protein-coupled receptors 
but are only distantly related to the receptors of the main olfactory 
system, highlighting their different role [8].
 
The V2 receptors are members of the metabotropic glutamate receptor-like 
family of GPCRs and have close similarity to the extracellular Ca2+-sensing 
receptors [9]. Rodents appear to have around 100 functional V2 receptors and 
many pseudogenes [8]. These receptors are expressed in the basal regions of 
the VNO, where they couple to Go proteins to mediate inositol trisphosphate
responses [7]. Homologues have also been identified in fish [10], and the
ligand specificity of one such receptor has been determined: a receptor from
goldfish olfactory epithelium has been reported to bind basic amino acids,
which are odorants for fish [11].
 
VOMERONASL2R is a 9-element fingerprint that provides a signature for the
vomeronasal type 2 receptor family. The fingerprint was derived from an
initial alignment of 11 sequences: the motifs were drawn from conserved
sections within N-terminal and external loop regions, focusing on those
areas of the alignment that characterise the vomeronasal type 2 receptors
but distinguish them from the rest of the metabotropic glutamate receptor
superfamily - motifs 1-6 lie within the large N-terminal domain; motif 7
spans part of TM domain 2, leading into the first external loop; and motifs
8 and 9 span the second external loop. Two iterations on SPTR39_15f were
required to reach convergence, at which point a true set comprising 14
sequences was identified. Several partial matches were also found, all of
which are vomeronasal type 2 receptors or members of the closely related 
extracellular Ca2+-sensing receptor family. Many of the vomeronasal 
receptors that fail to match a number of motifs are pseudogenes.
Summary Information
  14 codes involving  9 elements
1 codes involving 8 elements
3 codes involving 7 elements
1 codes involving 6 elements
1 codes involving 5 elements
6 codes involving 4 elements
3 codes involving 3 elements
2 codes involving 2 elements
Composite Feature Index
9141414141414141414
8111011111
7213222333
6111111000
5100011101
4616650000
3323010000
2210001000
123456789
True Positives
O35189        O35192        O35202        O35266        
O35268 O35269 O35271 O73636
O73637 O73638 O73639 O93552
O93553 Q9QWK0
True Positive Partials
Codes involving 8 elements
O35267
Codes involving 7 elements
O35190 O35265 O70409
Codes involving 6 elements
O35270
Codes involving 5 elements
O73640
Codes involving 4 elements
CASR_BOVIN CASR_HUMAN CASR_RAT O35199
O70410 Q9QY96
Codes involving 3 elements
O35197 O35198 O73635
Codes involving 2 elements
O35200 Q9PW88
Sequence Titles
O35189      PUTATIVE PHEROMONE RECEPTOR - Mus musculus (Mouse). 
O35192 PUTATIVE PHEROMONE RECEPTOR - Mus musculus (Mouse).
O35202 PUTATIVE PHEROMONE RECEPTOR - Mus musculus (Mouse).
O35266 PUTATIVE PHEROMONE RECEPTOR - Rattus norvegicus (Rat).
O35268 PUTATIVE PHEROMONE RECEPTOR - Rattus norvegicus (Rat).
O35269 PUTATIVE PHEROMONE RECEPTOR - Rattus norvegicus (Rat).
O35271 PUTATIVE PHEROMONE RECEPTOR - Rattus norvegicus (Rat).
O73636 PHEROMONE RECEPTOR - Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).
O73637 PHEROMONE RECEPTOR - Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).
O73638 PHEROMONE RECEPTOR - Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).
O73639 PHEROMONE RECEPTOR - Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).
O93552 PUTATIVE ODORANT RECEPTOR - Carassius auratus (Goldfish).
O93553 PUTATIVE ODORANT RECEPTOR - Carassius auratus (Goldfish).
Q9QWK0 PUTATIVE PHEROMONE RECEPTOR - Rattus norvegicus (Rat).

O35267 PUTATIVE PHEROMONE RECEPTOR - Rattus norvegicus (Rat).

O35190 PUTATIVE PHEROMONE RECEPTOR - Mus musculus (Mouse).
O35265 PUTATIVE PHEROMONE RECEPTOR - Rattus norvegicus (Rat).
O70409 PUTATIVE PHEROMONE RECEPTOR V2R1 - Mus musculus (Mouse).

O35270 PUTATIVE PHEROMONE RECEPTOR - Rattus norvegicus (Rat).

O73640 PHEROMONE RECEPTOR - Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).

CASR_BOVIN EXTRACELLULAR CALCIUM-SENSING RECEPTOR PRECURSOR (CASR) (PARATHYROID CELL CALCIUM-SENSING RECEPTOR) - Bos taurus (Bovine).
CASR_HUMAN EXTRACELLULAR CALCIUM-SENSING RECEPTOR PRECURSOR (CASR) (PARATHYROID CELL CALCIUM-SENSING RECEPTOR) - Homo sapiens (Human).
CASR_RAT EXTRACELLULAR CALCIUM-SENSING RECEPTOR PRECURSOR (CASR) (PARATHYROID CELL CALCIUM-SENSING RECEPTOR) - Rattus norvegicus (Rat).
O35199 PUTATIVE PHEROMONE RECEPTOR - Mus musculus (Mouse).
O70410 PUTATIVE PHEROMONE RECEPTOR V2R2 - Mus musculus (Mouse).
Q9QY96 EXTRACELLULAR CALCIUM-SENSING RECEPTOR PRECURSOR (CASR) (CAR) (PARATHYROID CELL CALCIUM-SENSING RECEPTOR) - Mus musculus (Mouse).

O35197 PUTATIVE PHEROMONE RECEPTOR - Mus musculus (Mouse).
O35198 PUTATIVE PHEROMONE RECEPTOR - Mus musculus (Mouse).
O73635 CALCIUM2+ SENSING RECEPTOR - Fugu rubripes (Japanese pufferfish) (Takifugu rubripes).

O35200 PUTATIVE PHEROMONE RECEPTOR - Mus musculus (Mouse).
Q9PW88 ODORANT RECEPTOR 5.24 - Carassius auratus (Goldfish).
Scan History
SPTR39_15f 2  150  NSINGLE    
Initial Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
KETQNKEICFAFVNMMSI O35266 146 146 -
KQSENKEICFAFVKMISV O35192 230 230 -
REMEKNTVCFAFVNIIPV O35268 239 239 -
NEMDKNGVCTAFVEMIPV O35269 150 150 -
EESQRHGICLAFVNMIPE O35189 227 227 -
KVAEQMGICLEYSLPFFR O93553 233 233 -
HAAQKEGICVEYSESFYR O73636 258 258 -
KTVQEEGICVEYSVKFYR O93552 230 230 -
MAAEQEGVCVEYSEGFSW O73638 233 233 -
DLVQSGQGCLAYLEVLPW O73637 240 240 -
NEVRRLGACIALYEMIPK O73639 249 249 -

Motif 2 width=13
Element Seqn Id St Int Rpt
KTEMYYNQIVMSS O35266 171 7 -
KTEINYKQIVKSL O35192 255 7 -
RAEVYYSQVMTSS O35268 264 7 -
KSWKNHVQILESS O35269 175 7 -
RATIYDKHIMTSS O35189 252 7 -
KVIRIIEQIKSST O93553 256 5 -
RIKRVADVIRRST O73636 281 5 -
KLKKVVDTIKKGT O93552 252 4 -
QIARVVTVIKSGS O73638 256 5 -
ENRRIVHVIKEST O73637 263 5 -
AISSIISNIRSSG O73639 272 5 -

Motif 3 width=12
Element Seqn Id St Int Rpt
HHHGEISGFTNF O35266 241 57 -
PHHGEISGFKNF O35192 325 57 -
HRHSEISGFKYF O35268 334 57 -
HHREEIPNFTDF O35269 245 57 -
HHRFEIPKLNKF O35189 322 57 -
IPKTQVTGLQEF O93553 327 58 -
IQRSVIPGLRDF O73636 349 55 -
MKKINIEGFAEY O93552 323 58 -
IRKTKITGLQEF O73638 327 58 -
IRRGEITGLRDF O73637 334 58 -
IRRADIPGLQDF O73639 344 59 -

Motif 4 width=18
Element Seqn Id St Int Rpt
YDIVHIQNFSQHLRIKMK O35266 380 127 -
YDIVHFANLSQHLGIKMK O35192 464 127 -
YDIFYNWNFPQGLGFKVK O35268 473 127 -
YDILNFWNFPKGLGLNVK O35269 385 128 -
YDIFIIWNFPQGLGLKVK O35189 461 127 -
YDIINWHPSKKQHYEFVT O93553 463 124 -
YELVNWKKSGSGSIEVVP O73636 483 122 -
YEVVNWQQDSDGTYQFKS O93552 448 113 -
YELVNWQRSPEGNTVFVV O73638 468 129 -
YDILNWQWLPDGRTQVQN O73637 478 132 -
YDLINWQLTPGGDMDFVT O73639 490 134 -

Motif 5 width=14
Element Seqn Id St Int Rpt
SPGFRKSWKEGMAP O35266 437 39 -
SPGFRRLWKEGMAA O35192 521 39 -
GPGFRKVWKNGMPA O35268 530 39 -
HPGFRKTHQEGRVA O35269 442 39 -
TAGFRKIYQKETAD O35189 519 40 -
PPGTRKGVKKGKPI O93553 520 39 -
PQGTRKVLQKGKPI O73636 539 38 -
PPGTRKAAQKGRPF O93552 505 39 -
IPGFRQAVIKGKPI O73638 525 39 -
PPGTRMSRKKGQPV O73637 535 39 -
PPGTRKAIRPNYPI O73639 548 40 -

Motif 6 width=13
Element Seqn Id St Int Rpt
PENEISNETNMDQ O35266 459 8 -
PENEISNETNMDQ O35192 543 8 -
PENEISNETNVEL O35268 552 8 -
PENEISNETDVDQ O35269 464 8 -
PENEISNETDMEQ O35189 541 8 -
TEGEISNTTDSVT O93553 542 8 -
PEGEISNVTDSPE O73636 561 8 -
AEGEISNETRFIN O93552 527 8 -
AAGEISNSSNSAE O73638 547 8 -
SEGKISNTTDSME O73637 557 8 -
TAGEISNQTDAIE O73639 570 8 -

Motif 7 width=10
Element Seqn Id St Int Rpt
MFCFLCSFFF O35266 549 77 -
MFCFLCSFFF O35192 633 77 -
IFCFLCPLFF O35268 642 77 -
MLCFLCPLLF O35269 554 77 -
VFCFLCSLLF O35189 631 77 -
MLCFLCSLTF O93553 632 77 -
TLCFLCSLTF O73636 651 77 -
TLCFLCSLTF O93552 617 77 -
TLCFLCSLTF O73638 637 77 -
KLCFLCSLLF O73637 647 77 -
TLCFLCSLTF O73639 660 77 -

Motif 8 width=16
Element Seqn Id St Int Rpt
FVDIDEHSEHGHIMIV O35266 639 80 -
FVDIDEHSQHGHIIIV O35192 723 80 -
SVDIDAQSEHGHIIIA O35268 732 80 -
FIDKDAHSEHGHIIII O35269 644 80 -
FIDRDIQSEHGKIVIL O35189 721 80 -
FPFKNLNYFKEKIILE O93553 722 80 -
FPVRNLTTYKERIILE O73636 741 80 -
FPYKNMKYYKEKIILE O93552 707 80 -
HPHKNTAHAKERIILE O73638 726 79 -
KPHKNIQYHKDKIVFE O73637 738 81 -
TPRQYMPRESAIIILL O73639 750 80 -

Motif 9 width=12
Element Seqn Id St Int Rpt
NKGSIMAFYCVL O35266 656 1 -
NKGSVTAFYCVL O35192 740 1 -
NKGSVTAFYCVL O35268 749 1 -
NKGSAVAFHCNL O35269 661 1 -
NKGSVIAFHVVL O35189 738 1 -
NVGSVVGFWAVL O93553 739 1 -
ALGSSVGFWAVL O73636 758 1 -
SLGSTIGFWAVL O93552 724 1 -
NLGSPVWFWVVL O73638 743 1 -
VVGSTVGFAVLL O73637 755 1 -
DEGSTIAFSLVL O73639 767 1 -
Final Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
KETQNKEICFAFVNMMSI O35266 146 146 -
KESQTKDICFAFVNMISV O35271 230 230 -
KQSENKEICFAFVKMISV O35192 230 230 -
KQSENKEICFAFVKMISV O35202 230 230 -
KETHNTEICFAFVNMMAI Q9QWK0 226 226 -
REMEKNTVCFAFVNIIPV O35268 239 239 -
NEMDKNGVCTAFVEMIPV O35269 150 150 -
EESQRHGICLAFVNMIPE O35189 227 227 -
KVAEQMGICLEYSLPFFR O93553 233 233 -
HAAQKEGICVEYSESFYR O73636 258 258 -
KTVQEEGICVEYSVKFYR O93552 230 230 -
MAAEQEGVCVEYSEGFSW O73638 233 233 -
DLVQSGQGCLAYLEVLPW O73637 240 240 -
NEVRRLGACIALYEMIPK O73639 249 249 -

Motif 2 width=13
Element Seqn Id St Int Rpt
KTEMYYNQIVMSS O35266 171 7 -
KTEMYYNQIVMSS O35271 255 7 -
KTEINYKQIVKSL O35192 255 7 -
NTEMYYNQIVMSS O35202 255 7 -
KTDMYYNQIVMST Q9QWK0 251 7 -
RAEVYYSQVMTSS O35268 264 7 -
KSWKNHVQILESS O35269 175 7 -
RATIYDKHIMTSS O35189 252 7 -
KVIRIIEQIKSST O93553 256 5 -
RIKRVADVIRRST O73636 281 5 -
KLKKVVDTIKKGT O93552 252 4 -
QIARVVTVIKSGS O73638 256 5 -
ENRRIVHVIKEST O73637 263 5 -
AISSIISNIRSSG O73639 272 5 -

Motif 3 width=12
Element Seqn Id St Int Rpt
HHHGEISGFTNF O35266 241 57 -
HHYGEISGFKNF O35271 325 57 -
PHHGEISGFKNF O35192 325 57 -
PHHGVISGFKNF O35202 325 57 -
QHHDVISGFKNF Q9QWK0 321 57 -
HRHSEISGFKYF O35268 334 57 -
HHREEIPNFTDF O35269 245 57 -
HHRFEIPKLNKF O35189 322 57 -
IPKTQVTGLQEF O93553 327 58 -
IQRSVIPGLRDF O73636 349 55 -
MKKINIEGFAEY O93552 323 58 -
IRKTKITGLQEF O73638 327 58 -
IRRGEITGLRDF O73637 334 58 -
IRRADIPGLQDF O73639 344 59 -

Motif 4 width=18
Element Seqn Id St Int Rpt
YDIVHIQNFSQHLRIKMK O35266 380 127 -
YNIVHMWNFSQRLGIKVK O35271 464 127 -
YDIVHFANLSQHLGIKMK O35192 464 127 -
YDIVHFVNLSQHLGIKMK O35202 466 129 -
YDIVHLQNCSQHLRIKVK Q9QWK0 460 127 -
YDIFYNWNFPQGLGFKVK O35268 473 127 -
YDILNFWNFPKGLGLNVK O35269 385 128 -
YDIFIIWNFPQGLGLKVK O35189 461 127 -
YDIINWHPSKKQHYEFVT O93553 463 124 -
YELVNWKKSGSGSIEVVP O73636 483 122 -
YEVVNWQQDSDGTYQFKS O93552 448 113 -
YELVNWQRSPEGNTVFVV O73638 468 129 -
YDILNWQWLPDGRTQVQN O73637 478 132 -
YDLINWQLTPGGDMDFVT O73639 490 134 -

Motif 5 width=14
Element Seqn Id St Int Rpt
SPGFRKSWKEGMAP O35266 437 39 -
HPGFRRIWKEEMAA O35271 521 39 -
SPGFRRLWKEGMAA O35192 521 39 -
SPGFRRLWKEGMAA O35202 523 39 -
RPGYRKFWKEGMAA Q9QWK0 517 39 -
GPGFRKVWKNGMPA O35268 530 39 -
HPGFRKTHQEGRVA O35269 442 39 -
TAGFRKIYQKETAD O35189 519 40 -
PPGTRKGVKKGKPI O93553 520 39 -
PQGTRKVLQKGKPI O73636 539 38 -
PPGTRKAAQKGRPF O93552 505 39 -
IPGFRQAVIKGKPI O73638 525 39 -
PPGTRMSRKKGQPV O73637 535 39 -
PPGTRKAIRPNYPI O73639 548 40 -

Motif 6 width=13
Element Seqn Id St Int Rpt
PENEISNETNMDQ O35266 459 8 -
PENEISNETMVVF O35271 543 8 -
PENEISNETNMDQ O35192 543 8 -
PENEISNETTVVL O35202 545 8 -
PDNEISNETTVVL Q9QWK0 539 8 -
PENEISNETNVEL O35268 552 8 -
PENEISNETDVDQ O35269 464 8 -
PENEISNETDMEQ O35189 541 8 -
TEGEISNTTDSVT O93553 542 8 -
PEGEISNVTDSPE O73636 561 8 -
AEGEISNETRFIN O93552 527 8 -
AAGEISNSSNSAE O73638 547 8 -
SEGKISNTTDSME O73637 557 8 -
TAGEISNQTDAIE O73639 570 8 -

Motif 7 width=10
Element Seqn Id St Int Rpt
MFCFLCSFFF O35266 549 77 -
MFCFLCSFFF O35271 583 27 -
MFCFLCSFFF O35192 633 77 -
MSCFLCSFFF O35202 585 27 -
MFCFLCSFFF Q9QWK0 579 27 -
IFCFLCPLFF O35268 642 77 -
MLCFLCPLLF O35269 554 77 -
VFCFLCSLLF O35189 631 77 -
MLCFLCSLTF O93553 632 77 -
TLCFLCSLTF O73636 651 77 -
TLCFLCSLTF O93552 617 77 -
TLCFLCSLTF O73638 637 77 -
KLCFLCSLLF O73637 647 77 -
TLCFLCSLTF O73639 660 77 -

Motif 8 width=16
Element Seqn Id St Int Rpt
FVDIDEHSEHGHIMIV O35266 639 80 -
FVDIDEHSEHGHIIIV O35271 673 80 -
FVDIDEHSQHGHIIIV O35192 723 80 -
FVDIDEHTLHGHIIIV O35202 675 80 -
FVDIDEHSEHGHIIIV Q9QWK0 669 80 -
SVDIDAQSEHGHIIIA O35268 732 80 -
FIDKDAHSEHGHIIII O35269 644 80 -
FIDRDIQSEHGKIVIL O35189 721 80 -
FPFKNLNYFKEKIILE O93553 722 80 -
FPVRNLTTYKERIILE O73636 741 80 -
FPYKNMKYYKEKIILE O93552 707 80 -
HPHKNTAHAKERIILE O73638 726 79 -
KPHKNIQYHKDKIVFE O73637 738 81 -
TPRQYMPRESAIIILL O73639 750 80 -

Motif 9 width=12
Element Seqn Id St Int Rpt
NKGSIMAFYCVL O35266 656 1 -
NKGSITAFYCVL O35271 690 1 -
NKGSVTAFYCVL O35192 740 1 -
NKGSVTAFYCIL O35202 692 1 -
NKGSVMAFYCVL Q9QWK0 686 1 -
NKGSVTAFYCVL O35268 749 1 -
NKGSAVAFHCNL O35269 661 1 -
NKGSVIAFHVVL O35189 738 1 -
NVGSVVGFWAVL O93553 739 1 -
ALGSSVGFWAVL O73636 758 1 -
SLGSTIGFWAVL O93552 724 1 -
NLGSPVWFWVVL O73638 743 1 -
VVGSTVGFAVLL O73637 755 1 -
DEGSTIAFSLVL O73639 767 1 -