Identifier | BUTYPHLNCDUF  [View Relations]  [View Alignment]  
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Accession | PR01407 |
No. of Motifs | 6 |
Creation Date | 25-APR-2000 |
Title | Butyrophylin C-terminal DUF signature |
Database References | PRINTS; PR01406 BBOXZNFINGER PFAM; PF00622 SPRY INTERPRO; IPR000107 |
Literature References | 1. BORDEN, K.L.
RING fingers and B-boxes: zinc-binding protein-protein interaction domains.
BIOCHEM.CELL BIOL. 76 351-358 (1998).
2. BORDEN, K.L., LALLY, J.M., MARTIN, S.R., O'REILLY, N.J., ETKIN, L.D.
AND FREEMONT, P.S.
Novel topology of a zinc-binding domain from a protein involved in
regulating early Xenopus development.
EMBO J. 14(23) 5947-5956 (1995).
3. PONTING, C., SCHULTZ, J. AND BORK, P
SPRY domains in ryanodine receptors (Ca(2+)-release channels).
TRENDS BIOCHEM.SCI. 22 193-194 (1997).
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Documentation | Several proteins that contain RING fingers also contain a well-conserved
40-residue cysteine-rich domain termed a B-box zinc finger. Often, one or
two copies of the B-box are associated with a coiled coil domain in addition
to the ring finger, forming a tripartite motif. The tripartite motif is
found in transcription factors, ribonucleoproteins and proto-oncoproteins,
but no function has yet been ascribed to the domain [1].
The solution structure of the B-box motif has been determined by NMR [2].
The protein is a monomer, with 2 beta-strands, 2 helical turns and 3
extended loop regions packed in a novel topology [2]. Of 7 potential zinc
ligands, only 4 are used, binding a single zinc atom in a C2-H2 tetrahedral
arrangement [2]. The B-box structure differs in tertiary fold from all
other known zinc-binding motifs.
A group of proteins that contain the B-box motif also host a well conserved
domain of unknown function (DUF). Proteins that include this domain are,
e.g.: butyrophilin, the RET finger protein, the 52kDa Ro protein and the
Xenopus nuclear factor protein. The C-terminal portion of this region has
been termed the SPRY domain (after SPla and the RYanodine Receptor) [1].
BUTYPHLNCDUF is a 6-element fingerprint that provides a signature for the
butyrophilin C-terminal domain and related proteins. The fingerprint was
derived from an initial alignment of 7 proteins: the motifs were drawn from
short conserved regions spanning the C-terminal portion of the alignment -
motifs 1-3 lie N-terminal to the SPRY domain, and motifs 4-6 reside within
it. Five iterations on SPTR37_10f were required to reach convergence, at
which point a true set comprising 26 sequences was identified. Several
partial matches were also found, all of which are related DNA-binding
proteins that fail to match one or more motifs.
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Summary Information | 26 codes involving 6 elements 0 codes involving 5 elements 1 codes involving 4 elements 2 codes involving 3 elements 7 codes involving 2 elements
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Composite Feature Index | 6 | 26 | 26 | 26 | 26 | 26 | 26 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 1 | 1 | 1 | 1 | 3 | 1 | 0 | 2 | 1 | 2 | 0 | 2 | 2 | 0 | 6 | 0 | 4 | 2 | | 1 | 2 | 3 | 4 | 5 | 6 |
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True Positives | A33_PLEWA BUTY_BOVIN BUTY_HUMAN BUTY_MOUSE O00475 O00478 O00480 O00481 O00635 O15553 O75656 O75657 O75658 O75677 O75678 O75679 O95604 P78408 P78409 Q12899 Q91431 Q92021 RFP_HUMAN RFP_MOUSE RO52_HUMAN RO52_MOUSE |
True Positive Partials | |
Sequence Titles | A33_PLEWA ZINC-BINDING PROTEIN A33 - PLEURODELES WALTLII (IBERIAN RIBBED NEWT). BUTY_BOVIN BUTYROPHILIN PRECURSOR (BT) - BOS TAURUS (BOVINE). BUTY_HUMAN BUTYROPHILIN PRECURSOR (BT) - HOMO SAPIENS (HUMAN). BUTY_MOUSE BUTYROPHILIN PRECURSOR (BT) - MUS MUSCULUS (MOUSE). O00475 BUTYROPHILIN - HOMO SAPIENS (HUMAN). O00478 BUTYROPHILIN - HOMO SAPIENS (HUMAN). O00480 BUTYROPHILIN (BTF2) (BUTYROPHILIN) - HOMO SAPIENS (HUMAN). O00481 BUTYROPHILIN - HOMO SAPIENS (HUMAN). O00635 SIMILAR TO THE 52KD RO/SSA PROTEIN AND RFP - HOMO SAPIENS (HUMAN). O15553 PYRIN - HOMO SAPIENS (HUMAN). O75656 DJ45P21.2 (BUTYROPHILIN) - HOMO SAPIENS (HUMAN). O75657 BTF5 (BUTYROPHILIN) - HOMO SAPIENS (HUMAN). O75658 BTF4 (BUTYROPHILIN) - HOMO SAPIENS (HUMAN). O75677 RFPL1L - HOMO SAPIENS (HUMAN). O75678 RET FINGER PROTEIN-LIKE 2 - HOMO SAPIENS (HUMAN). O75679 RET FINGER PROTEIN-LIKE 3 - HOMO SAPIENS (HUMAN). O95604 ZINC FINGER PROTEIN - HOMO SAPIENS (HUMAN). P78408 BUTYROPHILIN PROTEIN - HOMO SAPIENS (HUMAN). P78409 BUTYROPHILIN - HOMO SAPIENS (HUMAN). Q12899 ACID FINGER PROTEIN - HOMO SAPIENS (HUMAN). Q91431 NUCLEAR FACTOR 7 - XENOPUS LAEVIS (AFRICAN CLAWED FROG). Q92021 XNF7=ZINC FINGER NUCLEAR PHOSPHOPROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG). RFP_HUMAN ZINC-FINGER PROTEIN RFP (RET FINGER PROTEIN) - HOMO SAPIENS (HUMAN). RFP_MOUSE ZINC-FINGER PROTEIN RFP (RET FINGER PROTEIN) - MUS MUSCULUS (MOUSE). RO52_HUMAN 52 KD RO PROTEIN (SJOGREN SYNDROME TYPE A ANTIGEN (SS-A)) (RO(SS-A)) - HOMO SAPIENS (HUMAN). RO52_MOUSE 52 KD RO PROTEIN (SJOGREN SYNDROME TYPE A ANTIGEN (SS-A)) (RO(SS-A)) (RO52) - MUS MUSCULUS (MOUSE). Q91885 RING FINGER PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG). O95361 ESTROGEN-RESPONSIVE B BOX PROTEIN - HOMO SAPIENS (HUMAN). Q91884 RING FINGER PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG). O15344 PUTATIVE TRANSCRIPTION FACTOR XPRF (MIDLINE 1 FETAL KIDNEY ISOFORM 3) - HOMO SAPIENS (HUMAN). O35418 MIDLINE 1 (RING FINGER PROTEIN) - MUS MUSCULUS (MOUSE). O70583 MIDLINE 1 (MIDLINE 1 PROTEIN) - MUS MUSCULUS (MOUSE). Q14258 ESTROGEN RESPONSIVE FINGER PROTEIN (EFP) - HOMO SAPIENS (HUMAN). Q61510 ESTROGEN-RESPONSIVE FINGER PROTEIN - MUS MUSCULUS (MOUSE). Q91453 STONUSTOXIN BETA-SUBUNIT - SYNANCEIA HORRIDA. Y129_HUMAN HYPOTHETICAL PROTEIN KIAA0129 - HOMO SAPIENS (HUMAN).
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Scan History | SPTR37_10f 5 75 NSINGLE
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Initial Motifs | Motif 1 width=18 Element Seqn Id St Int Rpt GLAPLTLDPNTAHPNLVL A33_PLEWA 444 444 - HAVDVTLDPDTAHPHLFL BUTY_HUMAN 301 301 - YSVDVTLDPDTAYPSLIL RFP_MOUSE 323 323 - YSVDVTLDPDTAYPSLIL RFP_HUMAN 314 314 - CAVHITLDPDTANPWLIL RO52_HUMAN 285 285 - HAVDVTLDPDTAHPHLFL BUTY_BOVIN 301 301 - HEVDVTLDPDTAHPHLFL BUTY_MOUSE 302 302 - Motif 2 width=18 Element Seqn Id St Int Rpt LYEDSKSVRLEDSRQKLP BUTY_BOVIN 318 -1 - LYEDSKSVRLEDSRQILP BUTY_MOUSE 319 -1 - LYEDSKSVRLEDSRQKLP BUTY_HUMAN 318 -1 - LSEGLTSVKYTDTKQQLP A33_PLEWA 461 -1 - LSDNLRQVRYSYLQQDLP RFP_MOUSE 340 -1 - LSDNLRQVRYSYLQQDLP RFP_HUMAN 331 -1 - LSEDRRQVRLGDTQQSIP RO52_HUMAN 302 -1 - Motif 3 width=25 Element Seqn Id St Int Rpt RFSQCILVLGAEGFDSGKHYWEVEV A33_PLEWA 483 4 - RFDSWPCVLGRETFTSGRHYWEVEV BUTY_HUMAN 340 4 - RFDSWPCVLGRETFTSGRHYWEVEV BUTY_MOUSE 341 4 - RFDSWPCVMGREAFTSGRHYWEVEV BUTY_BOVIN 340 4 - RFDSYPMVLGAQHFHSGKHYWEVDV RO52_HUMAN 324 4 - RFNLFPCVLGSPCFIAGRHYWEVEV RFP_HUMAN 353 4 - RFNLFPCVLGSPCFIAGRHYWEVEV RFP_MOUSE 362 4 - Motif 4 width=14 Element Seqn Id St Int Rpt WAIGVCRENVVKKG BUTY_MOUSE 371 5 - WAIGVCRENVMKKG BUTY_HUMAN 370 5 - WAIGVCRENVMKKG BUTY_BOVIN 370 5 - WDLGVCRDSVRRKG RO52_HUMAN 354 5 - WTIGVCEDSVCRKG RFP_HUMAN 383 5 - WTIGVCEDSVCRKG RFP_MOUSE 392 5 - WDVGMASESSNRKG A33_PLEWA 513 5 - Motif 5 width=25 Element Seqn Id St Int Rpt LPLRTPLQRVGIFLDYDAGEVSFYN RFP_MOUSE 436 30 - LPLRTPLQRVGIFLDYDAGEVSFYN RFP_HUMAN 427 30 - LHLQVPPCQVGIFLDYEAGMVSFYN RO52_HUMAN 398 30 - LPLAGPPRRVGVFLDYESGDIFFYN BUTY_BOVIN 413 29 - LRLAGPPRRVGVFLDYDAGDISFYN BUTY_MOUSE 414 29 - LPLAGPPRRVGIFLDYESGDISFYN BUTY_HUMAN 413 29 - LNLTSKPSKIGVYLDYEGGQVSFYN A33_PLEWA 557 30 - Motif 6 width=19 Element Seqn Id St Int Rpt PIYTFNGSFTEKLYPYLSP A33_PLEWA 587 5 - TFTFSHATFCGPVRPYFSL RFP_MOUSE 467 6 - TFTFSHATFCGPVRPYFSL RFP_HUMAN 458 6 - IYSFSECAFTGPLRPFFSP RO52_HUMAN 430 7 - IYTFSKASFSGPLRPFFCL BUTY_BOVIN 444 6 - IYTFPSISFSGPLRPFFCL BUTY_MOUSE 445 6 - IYTFSNVTFSGPLRPFFCL BUTY_HUMAN 444 6 -
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Final Motifs | Motif 1 width=18 Element Seqn Id St Int Rpt FQVDMTLDADTANNFLLI O75679 94 94 - KTVSVTLDPQSASGYLQL Q12899 311 311 - DSGVITLDPQTASRSLVL O95604 292 292 - SLTPMLLDPTSAHPNLHL Q92021 430 430 - SLTPMLLDPNSAHPNLHL Q91431 431 431 - GLAPLTLDPNTAHPNLVL A33_PLEWA 444 444 - FQVDMTLDANTANNFLLI O75678 94 94 - HAVDVTLDPDTAHPHLFL BUTY_HUMAN 301 301 - CWVHITLDRNTANSWLII RO52_MOUSE 289 289 - FQVDMTLDADTANNFLLI O75677 94 94 - HAVNVILDAETAYPNLIF O15553 596 596 - HQVSVTLDPDTAHHELIL O00635 290 290 - HAANVVLDQDTGHPYLFV O75656 243 243 - LTPDVILYPDMANAILLV O75658 311 311 - SAADVILYPDMANAILLV P78409 496 496 - YSVDVTLDPDTAYPSLIL RFP_MOUSE 323 323 - YSVDVTLDPDTAYPSLIL RFP_HUMAN 314 314 - HAVDVVLDPDTAHPDLFL P78408 312 312 - KPADVILDPKTANPILLV O75657 320 320 - KPADVILDPKTANPILLV O00481 338 338 - CAVHITLDPDTANPWLIL RO52_HUMAN 285 285 - KPADVILDPDTANAILLV O00478 338 338 - HAVDVVLDPDTAHPDLFL O00475 326 326 - HAVDVTLDPDTAHPHLFL BUTY_BOVIN 301 301 - HAADVVLDPDTAHPELFL O00480 325 325 - HEVDVTLDPDTAHPHLFL BUTY_MOUSE 302 302 - Motif 2 width=18 Element Seqn Id St Int Rpt VSEDQRSVQRAKEPQDLP O75657 337 -1 - LSEDRRQVRLGDTQQSIP RO52_HUMAN 302 -1 - VSEDQRSVQRAEEPRDLP O00478 355 -1 - LSEDRRSVRRCPFRHLGE O00475 343 -1 - LYEDSKSVRLEDSRQKLP BUTY_BOVIN 318 -1 - LSEDRRSVRRGPYRQRVP O00480 342 -1 - LYEDSKSVRLEDSRQILP BUTY_MOUSE 319 -1 - LYEDSKSVRLEDSRQKLP BUTY_HUMAN 318 -1 - LSEDWKCVTYTSLYKSAY Q12899 328 -1 - LSEDRKSVRYTRQKKSLP O95604 309 -1 - LSDGLTSVRYGENKLSLP Q92021 447 -1 - LSDGLTSVRYGENKLSLP Q91431 448 -1 - LSEGLTSVKYTDTKQQLP A33_PLEWA 461 -1 - ISDDLRSVRSGRIRQNRQ O75678 111 -1 - ISDDLRSVRSGLITQNRQ O75679 111 -1 - ISKDRRQVRMGDTHQNVS RO52_MOUSE 306 -1 - ISDDLRSVRSGCITQNRQ O75677 111 -1 - FSDDLKSVRLGNKWERLP O15553 613 -1 - LSEDRRQVTRGYTQENQD O00635 307 -1 - VSEDKRSVTLDPSRESIP O75656 260 -1 - VSEDQRSVQRAEEPHDLP O75658 328 -1 - VSEDQRSVQRAEEPHDLP P78409 513 -1 - LSDNLRQVRYSYLQQDLP RFP_MOUSE 340 -1 - LSDNLRQVRYSYLQQDLP RFP_HUMAN 331 -1 - LSEDRRSVRRCPFRHLGE P78408 329 -1 - VSEDQRSVQRAKEPQDLP O00481 355 -1 - Motif 3 width=25 Element Seqn Id St Int Rpt RFDVSICILGSPRFTCGRHYWEVDV O75677 133 4 - RFSNYPMVLGAQRFSSGKMYWEVDV RO52_MOUSE 328 4 - RFDVSVCILGSPRFTCGRHYWEVDV O75679 133 4 - RFDVSVCILGSPRFTCGRHCWEVDV O75678 133 4 - RFSQCILVLGAEGFDSGKHYWEVEV A33_PLEWA 483 4 - RFSQCILVLGSQGFDSGRHYWEVEV Q91431 470 4 - RFSQCILVLGSQGFDSGRHYWEVEV Q92021 469 4 - RFDGLPAVLGFPGFSSGRHRWQVDL O95604 331 4 - QFDCEPGVLGSKGFTWGKVYWEVEV Q12899 350 4 - RFDSWPCVLGRETFTSGRHYWEVEV BUTY_HUMAN 340 4 - RFDSWPCVLGRETFTSGRHYWEVEV BUTY_MOUSE 341 4 - RFDSQPCVLGWESFASGKHYWEVEV O00480 364 4 - RFDSWPCVMGREAFTSGRHYWEVEV BUTY_BOVIN 340 4 - RFDSQPCVLGRESFASGKHYWEVEV O00475 368 7 - RFEWRYCVLGCENFTSGRHYWEVEV O00478 377 4 - RFDSYPMVLGAQHFHSGKHYWEVDV RO52_HUMAN 324 4 - RFNWHYCVLGCESFISGRHYWEVEV O00481 377 4 - RFNWHYCVLGCESFISGRHYWEVEV O75657 359 4 - RFDSQPCVLGRESFASGKHYWEVEV P78408 354 7 - RFNLFPCVLGSPCFIAGRHYWEVEV RFP_HUMAN 353 4 - RFNLFPCVLGSPCFIAGRHYWEVEV RFP_MOUSE 362 4 - RFEWRYCVLGCESFMSERHYWEVEV P78409 535 4 - RFEWRYCVLGCESFMSERHYWEVEV O75658 350 4 - RFDSQLCVLGQESFASGKHYLEVDV O75656 282 4 - RFTAFPCVLGCEGFTSGRRYFEVDV O00635 329 4 - RFDSCIIVLGSPSFLSGRRYWEVEV O15553 635 4 - Motif 4 width=14 Element Seqn Id St Int Rpt WDLGVCRESVHCKG O75679 163 5 - WDLGVCRDSVQRKG RO52_MOUSE 358 5 - WAIGVCRENVMKKG BUTY_HUMAN 370 5 - WAIGVCRENVVKKG BUTY_MOUSE 371 5 - WTVGVCRHSVERKG O00480 394 5 - WAIGVCRENVMKKG BUTY_BOVIN 370 5 - WTVGVCRDSVERKG O00475 398 5 - WHIGVCSKNVERKK O00478 407 5 - WDLGVCRDSVRRKG RO52_HUMAN 354 5 - WHIGVCSKNVQRKG O00481 407 5 - WHIGVCSKNVQRKG O75657 389 5 - WTVGVCRDSVERKG P78408 384 5 - WTIGVCEDSVCRKG RFP_HUMAN 383 5 - WTIGVCEDSVCRKG RFP_MOUSE 392 5 - WHIGVCSKNVERKK P78409 565 5 - WHIGVCSKNVERKK O75658 380 5 - WTVGICRDNVERKW O75656 312 5 - WDLGVCMENVQRGT O00635 359 5 - WILGACKTSISRKG O15553 665 5 - WDLGVCRESVHRKG O75677 163 5 - WDLGVCRESVHRKG O75678 163 5 - WDVGMASESSNRKG A33_PLEWA 513 5 - WDVGMASESSNRKG Q91431 500 5 - WDVGMASESSNRKG Q92021 499 5 - CTVGVAGEGVRRKG O95604 363 7 - CMVGVARDSVKRKG Q12899 437 62 - Motif 5 width=25 Element Seqn Id St Int Rpt LKLPEPPRKVGVILDYETGHISFYN P78409 610 31 - LPLRTPLQRVGIFLDYDAGEVSFYN RFP_MOUSE 436 30 - LPLRTPLQRVGIFLDYDAGEVSFYN RFP_HUMAN 427 30 - LPLKESLCRVGVFLDYEAGDVSFYN P78408 427 29 - LKLPKPPKKVGVFLDYETGDISFYN O75657 433 30 - LKLPKPPKKVGVFLDYETGDISFYN O00481 451 30 - LHLQVPPCQVGIFLDYEAGMVSFYN RO52_HUMAN 398 30 - LKLPEPPRKVGIFLDYETGEISFYN O00478 452 31 - LPLKESLCRVGVFLDYEAGDVSFYN O00475 441 29 - LPLAGPPRRVGVFLDYESGDIFFYN BUTY_BOVIN 413 29 - LPLKESLCRVGVFLDYEAGDVSFYN O00480 437 29 - LRLAGPPRRVGVFLDYDAGDISFYN BUTY_MOUSE 414 29 - LPLAGPPRRVGIFLDYESGDISFYN BUTY_HUMAN 413 29 - LHIQVPPCQIGIFVDYEAGVVSFYN RO52_MOUSE 401 29 - LFVDRKLQRVGIFLDMGMQNVSFFD O75677 207 30 - LLIKEPPKRVGIFVDYRVGSISFYN O15553 709 30 - LHLHEQPLLVGIFLDYEAGVVSFYN O00635 403 30 - LSLEEPLCQVGIFLDYEAGDVSFYN O75656 355 29 - LKLPEPPRKVGVILDYETGHISFYN O75658 425 31 - LLVDRKLQRVGIFLDMGMQNVSFFD O75679 207 30 - LFPALRPRRVGIALDYEGGTVTFTN Q12899 480 29 - LPLSEIPRGVRVALDYEAGQVTLHN O95604 406 29 - LSLSSHPRKIGVYVDYEGGQISFYN Q92021 543 30 - LSLTSHPRKIGVYVDYEGGQISFYN Q91431 544 30 - LNLTSKPSKIGVYLDYEGGQVSFYN A33_PLEWA 557 30 - LFVDRKLQRVGIFLDMGMQNVSFFD O75678 207 30 - Motif 6 width=19 Element Seqn Id St Int Rpt IYTFSNVTFSGPLRPFFCL BUTY_HUMAN 444 6 - LIYTFTATFTRRLVPFLWL Q12899 510 5 - PIFTFTASFSGKVFPFFAV O95604 436 5 - IIYTFNATFTEKLYPYLSP Q92021 573 5 - IIYTFSATFTEKLYPYLSP Q91431 574 5 - PIYTFNGSFTEKLYPYLSP A33_PLEWA 587 5 - VYTFRSVSAEEPLCPFLAP O75678 238 6 - VYTFRSVSAEEPLRPFLAP O75679 238 6 - IYTFSECVFAGPLRPFFNV RO52_MOUSE 433 7 - VYTFRSVSAEEPLHLFFAP O75677 238 6 - IYTFASCSFSGPLQPIFSP O15553 740 6 - IFTFPKASFSDTLRPYFQV O00635 434 6 - IYTFPHSAFSVPVRPFFSL O75656 386 6 - IYTFLHASSSEPLYPVFRI O75658 456 6 - IYTFLHASSSEPLYPVFRI P78409 641 6 - TFTFSHATFCGPVRPYFSL RFP_MOUSE 467 6 - TFTFSHATFCGPVRPYFSL RFP_HUMAN 458 6 - IYTCPRSAFSGPDTSQSGD P78408 458 6 - IHTFLDVSFSEALYPVFRI O75657 464 6 - IHTFLDVSFSEALYPVFRI O00481 482 6 - IYSFSECAFTGPLRPFFSP RO52_HUMAN 430 7 - IYTFPHASFSEPLYPVFRI O00478 483 6 - IYTCPRSAFSVPVRPFFRL O00475 472 6 - IYTFSKASFSGPLRPFFCL BUTY_BOVIN 444 6 - IYTCPRSAFTVPVRPFFRL O00480 468 6 - IYTFPSISFSGPLRPFFCL BUTY_MOUSE 445 6 -
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