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PR01367

Identifier
BGCRYSTALLIN  [View Relations]  [View Alignment]  
Accession
PR01367
No. of Motifs
4
Creation Date
25-AUG-2000
Title
Beta- and gamma-crystallin family signature
Database References
PRINTS; PR90008 CRYSTALLIN
PROSITE; PS00225 CRYSTALLIN_BETAGAMMA
PFAM; PF00030 crystall
INTERPRO; IPR001064
PDB; 1A45; 1A5D; 1BLB; 1GCS; 2BB2; 4GCR; 1AMM; 1ELP

PDB; 1DSL
SCOP; 1A45; 1A5D; 1BLB; 1GCS; 2BB2; 4GCR; 1AMM; 1ELP

SCOP; 1DSL
CATH; 1A45; 1A5D; 1BLB; 1GCS; 2BB2; 4GCR; 1AMM; 1ELP

CATH; 1DSL
Literature References
1. DE JONG, W.W., HENDRIKS, W., MULDERS, J.W.M. AND BLOEMENDAL, H.
Evolution of eye lens crystallins: the stress connection.
TRENDS BIOCHEM.SCI. 14 365-369 (1989).
 
2. SIMPSON, A., BATEMAN, O., DRIESSEN, H., LINDLEY, P., MOSS, D.,
YLVAGANAM, S., NAREBOR, E. AND SLINGSBY, C.
The structure of avian eye lens delta-crystallin reveals a new fold for a
superfamily of oligomeric enzymes.
STRUCT.BIOL. 1(10) 724-733 (1994).
 
3. CARVER, J.A.
Probing the structure and interactions of crystallin proteins by NMR
spectroscopy.
PROG.RETIN.EYE RES. 18(4) 431-462 (1999).
 
4. KROONE, R.C., ELLIOTT, G.S., FERSZT, A., SLINGSBY, C., LUBSEN, N.H. AND
SCHOENMAKERS, J.G.
The role of the sequence extensions in beta-crystallin assembly.
PROTEIN ENG. 7(11) 1395-9 (1994).
 
5. SLINGSBY, C. AND BATEMAN, O.A.
Quaternary interactions in eye lens beta-crystallins: basic and acidic
subunits of beta-crystallins favor heterologous association.
BIOCHEMISTRY 29(28) 6592-6599 (1990).
 
6. PALME, S., JAENICKE, R. AND SLINGSBY, C.
X-ray structures of three interface mutants of gammaB-crystallin from 
bovine eye lens.
PROTEIN SCI. 7(3) 611-618 (1998).

Documentation
The crystallins are water-soluble structural proteins that occur in high
concentration in the cytoplasm of eye lens fibre cells. Four major groups
of crystallin have been distinguished on the basis of size, charge and
immunological properties: alpha-, beta- and gamma-crystallins occur in all
vertebrate classes (though gamma-crystallins are low or absent in avian
lenses); and delta-crystallin is found exclusively in reptiles and birds
[1,2].
 
Both beta- and gamma-crystallins belong to the same family of highly
conserved proteins. They are found in high concentrations in the lens and
are responsible for its transparency. Beta- and gamma-crystallins display
high stability, characterised by their lack of turnover during the
life of the organism [3]. 
 
Structurally, each beta- and gamma-crystallin monomer is composed of two
domains that fold into `Greek key' structures [4]. Beta-crystallins
differ from gamma-crystallins by virtue of their N- and C-terminal
extensions. Those beta-crystallins with acidic extensions are termed beta-A
crystallins, while those with basic extensions are termed beta-B crystallins
[5].
 
Beta-crystallins form dimers, whereas gamma-crystallins exist as monomers,
although the C- and N-terminal extensions are not involved in this.
Misfolding, aggregation and dissolution are believed to be responsible
for the formation of cataracts [6].
 
BGCRYSTALLIN is a 4-element fingerprint that provides a signature for the
beta- and gamma-crystallin family. The fingerprint was derived from an
initial alignment of 6 sequences: the motifs were drawn from conserved
regions spanning the first and second greek keys. Three iterations on 
SPTR37_10f were required to reach convergence, at which point a true set 
comprising 73 sequences was identified. 
Summary Information
73 codes involving  4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
473737373
30000
20000
1234
True Positives
CB11_RANCA    CB12_RANCA    CB31_RANCA    CB32_RANCA    
CRB1_BOVIN CRB1_CHICK CRB1_HUMAN CRB1_RAT
CRB2_BOVIN CRB2_CHICK CRB2_HUMAN CRB2_MOUSE
CRB2_RANCA CRB2_RAT CRB3_BOVIN CRB3_CHICK
CRB3_HUMAN CRB3_RAT CRBA_BOVIN CRBA_CHICK
CRBA_HUMAN CRBA_MOUSE CRBA_RANTE CRBB_BOVIN
CRBB_CHICK CRBD_BOVIN CRBD_CHICK CRBD_HUMAN
CRBD_RAT CRBS_BOVIN CRBS_CHICO CRBS_CYPCA
CRBS_HUMAN CRBT_CHICO CRG1_CHICO CRG1_CYPCA
CRG1_RANCA CRG1_XENLA CRG2_CHICO CRG2_CYPCA
CRG2_RANCA CRG2_XENLA CRG3_CYPCA CRG3_XENLA
CRGA_BOVIN CRGA_HUMAN CRGA_MOUSE CRGA_RAT
CRGB_BOVIN CRGB_HUMAN CRGB_MOUSE CRGB_RAT
CRGC_HUMAN CRGC_MOUSE CRGC_RAT CRGD_BOVIN
CRGD_HUMAN CRGD_MOUSE CRGD_RAT CRGE_BOVIN
CRGE_MOUSE CRGE_RAT CRGF_BOVIN CRGF_RAT
O35486 O93615 Q31554 Q31555
Q90360 Q90361 Q90362 Q90363
Q90364
Sequence Titles
CB11_RANCA  BETA CRYSTALLIN A1-1 - RANA CATESBEIANA (BULL FROG). 
CB12_RANCA BETA CRYSTALLIN A1-2 - RANA CATESBEIANA (BULL FROG).
CB31_RANCA BETA CRYSTALLIN A3-1 - RANA CATESBEIANA (BULL FROG).
CB32_RANCA BETA CRYSTALLIN A3-2 - RANA CATESBEIANA (BULL FROG).
CRB1_BOVIN BETA CRYSTALLIN B1 - BOS TAURUS (BOVINE).
CRB1_CHICK BETA CRYSTALLIN B1 (BETA-35) - GALLUS GALLUS (CHICKEN).
CRB1_HUMAN BETA CRYSTALLIN B1 - HOMO SAPIENS (HUMAN).
CRB1_RAT BETA CRYSTALLIN B1 [CONTAINS: BETA B1B CRYSTALLIN] - RATTUS NORVEGICUS (RAT).
CRB2_BOVIN BETA CRYSTALLIN B2 (BP) - BOS TAURUS (BOVINE).
CRB2_CHICK BETA CRYSTALLIN B2 (BP) - GALLUS GALLUS (CHICKEN).
CRB2_HUMAN BETA CRYSTALLIN B2 (BP) - HOMO SAPIENS (HUMAN).
CRB2_MOUSE BETA CRYSTALLIN B2 (BP) - MUS MUSCULUS (MOUSE), AND MESOCRICETUS AURATUS (GOLDEN HAMSTER).
CRB2_RANCA BETA CRYSTALLIN B2 (BP) - RANA CATESBEIANA (BULL FROG).
CRB2_RAT BETA CRYSTALLIN B2 (BP) - RATTUS NORVEGICUS (RAT).
CRB3_BOVIN BETA CRYSTALLIN B3 - BOS TAURUS (BOVINE).
CRB3_CHICK BETA CRYSTALLIN B3 - GALLUS GALLUS (CHICKEN).
CRB3_HUMAN BETA CRYSTALLIN B3 - HOMO SAPIENS (HUMAN).
CRB3_RAT BETA CRYSTALLIN B3 - RATTUS NORVEGICUS (RAT).
CRBA_BOVIN BETA CRYSTALLIN A3 [CONTAINS: BETA CRYSTALLIN A1] - BOS TAURUS (BOVINE).
CRBA_CHICK BETA CRYSTALLIN A3 [CONTAINS: BETA CRYSTALLIN A1] - GALLUS GALLUS (CHICKEN).
CRBA_HUMAN BETA CRYSTALLIN A3 [CONTAINS: BETA CRYSTALLIN A1] - HOMO SAPIENS (HUMAN).
CRBA_MOUSE BETA CRYSTALLIN A1 - MUS MUSCULUS (MOUSE).
CRBA_RANTE BETA CRYSTALLIN A1 - RANA TEMPORARIA (EUROPEAN COMMON FROG).
CRBB_BOVIN BETA CRYSTALLIN A2 - BOS TAURUS (BOVINE).
CRBB_CHICK BETA CRYSTALLIN A2 - GALLUS GALLUS (CHICKEN).
CRBD_BOVIN BETA CRYSTALLIN A4 - BOS TAURUS (BOVINE).
CRBD_CHICK BETA CRYSTALLIN A4 - GALLUS GALLUS (CHICKEN).
CRBD_HUMAN BETA CRYSTALLIN A4 - HOMO SAPIENS (HUMAN).
CRBD_RAT BETA CRYSTALLIN A4 - RATTUS NORVEGICUS (RAT).
CRBS_BOVIN BETA CRYSTALLIN S (GAMMA CRYSTALLIN S) - BOS TAURUS (BOVINE).
CRBS_CHICO BETA CRYSTALLIN S-1 (GAMMA CRYSTALLIN S-1) - CHILOSCYLLIUM COLAX (LIP SHARK).
CRBS_CYPCA BETA CRYSTALLIN S (GAMMA CRYSTALLIN S) - CYPRINUS CARPIO (COMMON CARP).
CRBS_HUMAN BETA CRYSTALLIN S (GAMMA CRYSTALLIN S) - HOMO SAPIENS (HUMAN).
CRBT_CHICO BETA CRYSTALLIN S-2 (GAMMA CRYSTALLIN S-2) - CHILOSCYLLIUM COLAX (LIP SHARK).
CRG1_CHICO GAMMA CRYSTALLIN M1 (GAMMA-M1) - CHILOSCYLLIUM COLAX (LIP SHARK).
CRG1_CYPCA GAMMA CRYSTALLIN M1 (GAMMA-M1) - CYPRINUS CARPIO (COMMON CARP).
CRG1_RANCA GAMMA CRYSTALLIN M1-1 (GAMMA M1-1) - RANA CATESBEIANA (BULL FROG).
CRG1_XENLA GAMMA CRYSTALLIN I (GAMMA-1-CRY) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
CRG2_CHICO GAMMA CRYSTALLIN M2 (GAMMA-M2) - CHILOSCYLLIUM COLAX (LIP SHARK).
CRG2_CYPCA GAMMA CRYSTALLIN M2 (GAMMA-M2) - CYPRINUS CARPIO (COMMON CARP).
CRG2_RANCA GAMMA CRYSTALLIN M1-2 (GAMMA M1-2) - RANA CATESBEIANA (BULL FROG).
CRG2_XENLA GAMMA CRYSTALLIN II (GAMMA-2-CRY) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
CRG3_CYPCA GAMMA CRYSTALLIN M3 (GAMMA-M3) - CYPRINUS CARPIO (COMMON CARP).
CRG3_XENLA GAMMA CRYSTALLIN III (GAMMA-3-CRY) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
CRGA_BOVIN GAMMA CRYSTALLIN A (IVB) - BOS TAURUS (BOVINE).
CRGA_HUMAN GAMMA CRYSTALLIN A (GAMMA CRYSTALLIN 5) - HOMO SAPIENS (HUMAN).
CRGA_MOUSE GAMMA CRYSTALLIN A (4) - MUS MUSCULUS (MOUSE).
CRGA_RAT GAMMA CRYSTALLIN A (1-1) - RATTUS NORVEGICUS (RAT).
CRGB_BOVIN GAMMA CRYSTALLIN B (II) - BOS TAURUS (BOVINE).
CRGB_HUMAN GAMMA CRYSTALLIN B (GAMMA CRYSTALLIN 1-2) - HOMO SAPIENS (HUMAN).
CRGB_MOUSE GAMMA CRYSTALLIN B (3) - MUS MUSCULUS (MOUSE).
CRGB_RAT GAMMA CRYSTALLIN B (1-2) - RATTUS NORVEGICUS (RAT).
CRGC_HUMAN GAMMA CRYSTALLIN C (GAMMA CRYSTALLIN 2 OR 1/3) - HOMO SAPIENS (HUMAN).
CRGC_MOUSE GAMMA CRYSTALLIN C - MUS MUSCULUS (MOUSE).
CRGC_RAT GAMMA CRYSTALLIN C (2-1) - RATTUS NORVEGICUS (RAT).
CRGD_BOVIN GAMMA CRYSTALLIN D (IIIB) - BOS TAURUS (BOVINE).
CRGD_HUMAN GAMMA CRYSTALLIN D (GAMMA CRYSTALLIN 4) - HOMO SAPIENS (HUMAN).
CRGD_MOUSE GAMMA CRYSTALLIN D (1) - MUS MUSCULUS (MOUSE).
CRGD_RAT GAMMA CRYSTALLIN D (2-2) - RATTUS NORVEGICUS (RAT).
CRGE_BOVIN GAMMA CRYSTALLIN E (IIIA) (GAMMA-C-CRYSTALLIN) - BOS TAURUS (BOVINE).
CRGE_MOUSE GAMMA CRYSTALLIN E - MUS MUSCULUS (MOUSE).
CRGE_RAT GAMMA CRYSTALLIN E (3-1) (GAMMA-2) - RATTUS NORVEGICUS (RAT), AND MUS MUSCULUS (MOUSE).
CRGF_BOVIN GAMMA CRYSTALLIN F (IVA) - BOS TAURUS (BOVINE).
CRGF_RAT GAMMA CRYSTALLIN F (4-1) - RATTUS NORVEGICUS (RAT).
O35486 GAMMAS-CRYSTALLIN - MUS MUSCULUS (MOUSE).
O93615 GAMMA-CRYSTALLIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q31554 GAMMA-CRYSTALLIN M1-1 - PETENIA SPLENDIDA X CICHLASOMA SYNSPILUM.
Q31555 GAMMA-CRYSTALLIN M2-1 - PETENIA SPLENDIDA X CICHLASOMA SYNSPILUM.
Q90360 G-CRYSTALLIN - CLARIAS FUSCUS.
Q90361 G-CRYSTALLIN - CLARIAS FUSCUS.
Q90362 G-CRYSTALLIN - CLARIAS FUSCUS.
Q90363 G-CRYSTALLIN GAMMA S1 - CLARIAS FUSCUS.
Q90364 G-CRYSTALLIN GAMMA S2 - CLARIAS FUSCUS.
Scan History
SPTR37_10f 3  200  NSINGLE    
Initial Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
VESDWWVLYEKPNYMGYQHV CRBT_CHICO 37 37 -
VESGAWVIYERPNFMGYQYV CRBS_CYPCA 37 37 -
VECGAWIGYEHTSFCGQQFV CB11_RANCA 51 51 -
VQAGPWVGYEQANCKGEQFV CRB2_HUMAN 53 53 -
VQAGPWVGYEQANCKGEQFV CRB2_BOVIN 53 53 -
VESGPWVGFEYPEYQGQQFI CRBB_CHICK 49 49 -

Motif 2 width=15
Element Seqn Id St Int Rpt
LTRGEYPDYQRWMGF CRBT_CHICO 57 0 -
LTRGEYPDYQRWMGL CRBS_CYPCA 57 0 -
LERGEYPPWDAWSAT CB11_RANCA 71 0 -
FEKGEYPRWDSWTSS CRB2_HUMAN 73 0 -
FEKGEYPRWDSWTSS CRB2_BOVIN 73 0 -
LEKGDYPRWEAWSGN CRBB_CHICK 69 0 -

Motif 3 width=20
Element Seqn Id St Int Rpt
MRIYERPDFGGQMMEFMDVC CRBT_CHICO 90 18 -
IQLYDKGDFTGQVYESTEDC CRBS_CYPCA 91 19 -
LVIFEKENFIGRQWELRDDY CB11_RANCA 109 23 -
IILYENPNFTGKKMEIIDDD CRB2_HUMAN 108 20 -
ITLYENPNFTGKKMEVIDDD CRB2_BOVIN 108 20 -
AILYEAENFQGHKFELSDDY CRBB_CHICK 107 23 -

Motif 4 width=10
Element Seqn Id St Int Rpt
PGEYRRYSDW CRBT_CHICO 148 38 -
KGEYRKPVDW CRBS_CYPCA 149 38 -
GGEYKHWREW CB11_RANCA 172 43 -
KGDYKDSSDF CRB2_HUMAN 167 39 -
KGDYKDSGDF CRB2_BOVIN 167 39 -
NGEFKKYSEY CRBB_CHICK 170 43 -
Final Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
VDSGCWMLYERPNYQGHQYF CRGB_MOUSE 37 37 -
VDSGCWMLYERPNYQGHQYF CRGB_BOVIN 37 37 -
VDSGCWMLYERPNYQGHQYF CRGB_RAT 37 37 -
VDSGCWMLYEQPNFTGCQYF CRGE_RAT 37 37 -
VDSGCWMLYEQPNFTGCQYF CRGD_RAT 37 37 -
VDSGCWMIYEQPNYLGPQYF CRGD_BOVIN 37 37 -
VDSGCWMLYEQPNFQGPQYF CRGF_BOVIN 37 37 -
VDSGCWMLYQQPNFTGCQYF CRGE_MOUSE 37 37 -
VDSGCWMLYEQPNFAGCQYF CRGD_MOUSE 37 37 -
VESDWWVLYEKPNYMGYQYV CRBS_CHICO 37 37 -
VDSGCWMLYEQPNFTGCQYF CRGF_RAT 37 37 -
VEGGCWVLYEKPNYMGYQYF CRG2_CHICO 37 37 -
VDSGCWMLYERPNYQGYQYF CRGA_MOUSE 37 37 -
VESGCWMIYERPNYQGHQYF CRGB_HUMAN 37 37 -
VDSGCWMLYERPNYQGYQYF CRGA_RAT 37 37 -
VDSGCWMLYERPNYQGHQYF CRGC_MOUSE 37 37 -
VDSGCWMLYERPNYQGHQYF CRGC_RAT 37 37 -
VESGCWMLYERPNYQGQQYL CRGC_HUMAN 37 37 -
VESDWWVLYEKPNYMGYQHV CRBT_CHICO 37 37 -
VDSGCWMLYERPNYQGHQYF CRGA_HUMAN 37 37 -
VDSGCWMLYERPNYQGHQYF CRGE_BOVIN 37 37 -
VDSGCWMLYEQPNYSGLQYF CRGD_HUMAN 37 37 -
VESGNWILYEQPSYRGHQYY CRG3_XENLA 38 38 -
VESGNWILYEQPSYRGHQYY O93615 38 38 -
VEGGNWILYEHPSYKGNQYY CRG1_XENLA 38 38 -
VENGNWILYEQPSYRGHQYY CRG2_XENLA 38 38 -
VESGCFMVYERPNFMGMQFF Q31554 38 38 -
VENGCWMIYERPNYMGHQYF CRG2_RANCA 38 38 -
VESGAWVIYERPNFMGYQYV CRBS_CYPCA 37 37 -
VGRGCWMVYDRPNFMGNQFF Q90364 38 38 -
VENGCWMIYERPNYMGHPYF CRG1_RANCA 38 38 -
VDVHSWFVYQRPDYRGHQYM CRGA_BOVIN 37 37 -
VESGCFMVYERPNFMGMQFF CRG1_CHICO 37 37 -
VECGAWIGYEHTSFCGQQFV CB31_RANCA 68 68 -
VECGAWIGYEHTSFCGQQFV CB32_RANCA 68 68 -
VESGAWIGYEHTSFCGQQFI CRBA_HUMAN 68 68 -
VECGAWIGYEHTSFCGQQFV CB12_RANCA 51 51 -
VECGAWVGYEHTSFCGQQFV CRBA_BOVIN 67 67 -
VECGGWIGYEHTSFCGQQFV CRBA_RANTE 51 51 -
VESGCFMVYERNSYMGNQFF CRG1_CYPCA 37 37 -
VECGAWVGYEHTGFCGQQFI CRBA_CHICK 68 68 -
VECGAWIGYEHTSFCGQQFV CB11_RANCA 51 51 -
VLSGAWVGFEHAGFQGQQYV CRBD_BOVIN 62 62 -
VERGCWMVYDRPNFMGNQYF Q90362 38 38 -
VECGAWIGYEHTSFCGQQFI CRBA_MOUSE 51 51 -
VHSGCWMMYDQPNYMGNQYF CRG2_CYPCA 37 37 -
VESGCFVVYDVPNYMGNQFF CRG3_CYPCA 37 37 -
VESGPWLAFERRAFRGEQYV CRB3_BOVIN 60 60 -
IESGAWVGFEHCGFQGQQFV CRBD_CHICK 49 49 -
VESGCFVVCDRPNYMGSQYL Q31555 38 38 -
VLSGAWVGFEHAGFQGQQYI CRBD_HUMAN 48 48 -
VEGGTWAVYERPNFAGYMYI CRBS_BOVIN 41 41 -
VLSGAWVGFEHAGFQGQQYV CRBD_RAT 48 48 -
VESGPWLGFERQAFAGEQFV CRB3_CHICK 61 61 -
VEGGTWAVYERPNFAGYMYI CRBS_HUMAN 41 41 -
VESGFWMVYDRPNFMGNQYF Q90360 38 38 -
VEGGTWAVYERPNFSGHMYI O35486 42 42 -
VESGPWLAFESRAFRGEQFV CRB3_HUMAN 61 61 -
VESGCWMVYDRTNFMGNQYF Q90363 38 38 -
VESGPWLAFERRAFRGEQFV CRB3_RAT 61 61 -
VTSGPWVAFEQSNFRGEMFV CRB1_BOVIN 96 96 -
VHSGPWVGYEQQNCKGEQFV CRB2_RANCA 53 53 -
VERGCWMVYDRPNFMGNQYF Q90361 38 38 -
VQAGPWVGYEQANCKGEQFV CRB2_HUMAN 53 53 -
VQAGPWVGYEQANCKGEQFV CRB2_MOUSE 53 53 -
VLSGPWVAFEQSAFRGEMFV CRB1_RAT 92 92 -
VENGAWVAFEYPDFQGQQFI CRBB_BOVIN 49 49 -
VQAGPWVGYEQANCKGEQFV CRB2_BOVIN 53 53 -
VESGPWVGFEYPEYQGQQFI CRBB_CHICK 49 49 -
VSSGPWVAYEQANMRGEMFI CRB1_CHICK 83 83 -
VSAGPWVAFEQSNFRGEMFI CRB1_HUMAN 95 95 -
VHSGPWVGYEQASCKGEQFV CRB2_CHICK 53 53 -
VQAGPWVGYEQAKCKGEQFV CRB2_RAT 53 53 -

Motif 2 width=15
Element Seqn Id St Int Rpt
LRRGEYPDYQQWMGF CRGB_MOUSE 57 0 -
LRRGDYPDYQQWMGF CRGB_BOVIN 57 0 -
LRRGDYPDYQQWMGF CRGB_RAT 57 0 -
LRRGDYPDYQQWMGF CRGE_RAT 57 0 -
LRRGDYPDYQQWMGF CRGD_RAT 57 0 -
LRRGDYPDYQQWMGL CRGD_BOVIN 57 0 -
LRRGDYPDYQQWMGL CRGF_BOVIN 57 0 -
LRRGDYPDYQQWMGF CRGE_MOUSE 57 0 -
LRRGDYPDYQQWMGF CRGD_MOUSE 57 0 -
LTRGEYPDYQRWMGF CRBS_CHICO 57 0 -
LRRGDYPDYQQWMGF CRGF_RAT 57 0 -
LTRGEYPDYQRWMGF CRG2_CHICO 57 0 -
LRRGDYPDYQQWMGF CRGA_MOUSE 57 0 -
LRRGEYPDYQQWMGL CRGB_HUMAN 57 0 -
LRRGDYPDYQQWMGF CRGA_RAT 57 0 -
LRRGEYPDYQQWMGF CRGC_MOUSE 57 0 -
LRRGDYPDYQQWMGF CRGC_RAT 57 0 -
LRRGEYPDYQQWMGL CRGC_HUMAN 57 0 -
LTRGEYPDYQRWMGF CRBT_CHICO 57 0 -
LRRGKYPDYQHWMGL CRGA_HUMAN 57 0 -
LRRGDYPDYQQWMGF CRGE_BOVIN 57 0 -
LRRGDYADHQQWMGL CRGD_HUMAN 57 0 -
LWKGEYPDFQRWMGF CRG3_XENLA 58 0 -
LWKGEYPDFQRWMGF O93615 58 0 -
LWKGEYPDFQRWMGF CRG1_XENLA 58 0 -
LWKGEYPDFQRWMGF CRG2_XENLA 58 0 -
LRRGEYHDMQRMMSM Q31554 58 0 -
LKRGEYPDYQQCQGL CRG2_RANCA 58 0 -
LTRGEYPDYQRWMGL CRBS_CYPCA 57 0 -
IRRGEYPDYMSAWGW Q90364 58 0 -
LKRGEYPDYQQCQGL CRG1_RANCA 58 0 -
LQRGNYPQYGQWMGF CRGA_BOVIN 57 0 -
LRRGEYHDMQRMMSM CRG1_CHICO 57 0 -
LERGEYPRWDAWSGS CB31_RANCA 88 0 -
LERGEYPRWDAWSGS CB32_RANCA 88 0 -
LERGEYPRWDAWSGS CRBA_HUMAN 88 0 -
LERGEYPRWDAWSGS CB12_RANCA 71 0 -
LERGEYPRWDAWSGS CRBA_BOVIN 87 0 -
LERGEYPRWDAWSGS CRBA_RANTE 71 0 -
LRRGEYHDMQRMMSM CRG1_CYPCA 57 0 -
LERGEYPRWDAWSGS CRBA_CHICK 88 0 -
LERGEYPPWDAWSAT CB11_RANCA 71 0 -
LERGEYPSWDAWSGN CRBD_BOVIN 82 0 -
IKRGEYPDYMSMWGW Q90362 58 0 -
LERGEYPRWDAWSGS CRBA_MOUSE 71 0 -
FRRGEYADYMSMFGM CRG2_CYPCA 57 0 -
MRRGEYADYMRMGMS CRG3_CYPCA 57 0 -
LEKGDYPRWDAWSNS CRB3_BOVIN 80 0 -
LERGEYPCWEAWSGS CRBD_CHICK 69 0 -
LRRGEYSDYMSFGMS Q31555 58 0 -
LERGEYPSWDAWGGN CRBD_HUMAN 68 0 -
LPRGEYPEYQHWMGL CRBS_BOVIN 61 0 -
LERGDYPGWDAWGGN CRBD_RAT 68 0 -
LEKGDYPRWDSWSNS CRB3_CHICK 81 0 -
LPQGEYPEYQRWMGL CRBS_HUMAN 61 0 -
LKKGEYNDYIGTWGM Q90360 58 0 -
LPQGEYPEYQRWMGL O35486 62 0 -
LEKGDYPRWDAWSNS CRB3_HUMAN 81 0 -
MRRGEYADYMSMWGW Q90363 58 0 -
LEKGDYPAWDAWSSS CRB3_RAT 81 0 -
LEKGEYPRWDTWSSS CRB1_BOVIN 116 0 -
FEKGEYPRWDSWTNS CRB2_RANCA 73 0 -
IKRGEYPDYMSMWGW Q90361 58 0 -
FEKGEYPRWDSWTSS CRB2_HUMAN 73 0 -
FEKGEYPRWDSWTSS CRB2_MOUSE 73 0 -
LEKGEYPRWDTWTSS CRB1_RAT 112 0 -
LEKGDYPRWSAWSGS CRBB_BOVIN 69 0 -
FEKGEYPRWDSWTSS CRB2_BOVIN 73 0 -
LEKGDYPRWEAWSGN CRBB_CHICK 69 0 -
LEKGEYPRWDTWSSS CRB1_CHICK 103 0 -
LEKGEYPRWNTWSSS CRB1_HUMAN 115 0 -
FEKGEYPRWDSWTNS CRB2_CHICK 73 0 -
FEKGEYHQWDSWTSS CRB2_RAT 73 0 -

Motif 3 width=20
Element Seqn Id St Int Rpt
MRIYEKDDFRGQMSEITDDC CRGB_MOUSE 90 18 -
MRIYERDDFRGQMSEITDDC CRGB_BOVIN 90 18 -
MRIYERDDFRGQMSEITDDC CRGB_RAT 90 18 -
IRIYEREDYRGQMVEITDDC CRGE_RAT 89 17 -
IRLYEREDYRGQMVEFTEDC CRGD_RAT 89 17 -
LRLYEREDYRGQMIEITEDC CRGD_BOVIN 89 17 -
LRIYEREDYRGQMVEITEDC CRGF_BOVIN 89 17 -
IKIYEREDYRGQMVEITDDC CRGE_MOUSE 89 17 -
IRLYEREEYRGQVIEFTEDC CRGD_MOUSE 89 17 -
MRIYERLTFGGQMMEIMDDC CRBS_CHICO 90 18 -
IRIYEREDYRGQMVEITDDC CRGF_RAT 89 17 -
MRIYERPDFGGQMMEFMDDC CRG2_CHICO 90 18 -
IRLYERDDYRGLVSELMDDC CRGA_MOUSE 89 17 -
MKIYDRDELRGQMSELTDDC CRGB_HUMAN 90 18 -
IRLYERDDYRGLVSELTEDC CRGA_RAT 89 17 -
MRLYEKEDHKGVMMELSEDC CRGC_MOUSE 89 17 -
MRLYEKEDHKGVMMELSEDC CRGC_RAT 89 17 -
LRLYEREDHKGLMMELSEDC CRGC_HUMAN 89 17 -
MRIYERPDFGGQMMEFMDVC CRBT_CHICO 90 18 -
LRLYERDDYRGLMSELTDDC CRGA_HUMAN 89 17 -
LRLYEREDQKGLIAELSEDC CRGE_BOVIN 89 17 -
IRLYEREDYRGQMIEFTEDC CRGD_HUMAN 89 17 -
MRISERGDFQGQNMEFFEDC CRG3_XENLA 91 18 -
MRISERGDFQGQNMEFFEDC O93615 93 20 -
MRIYERGDYQGQMMEFFDDC CRG1_XENLA 91 18 -
MRIYERGDFQGKMMEFSDDC CRG2_XENLA 91 18 -
MRIYERENFGGQMSELMDDC Q31554 94 21 -
LRVYERGDSKGEMMEFLEDC CRG2_RANCA 93 20 -
IQLYDKGDFTGQVYESTEDC CRBS_CYPCA 91 19 -
MKIYERENFLGQMMEISDDC Q90364 92 19 -
LRVYERGDSKGEMMEFLEDC CRG1_RANCA 93 20 -
MRIYERDDFRGQMSEITDDC CRGA_BOVIN 90 18 -
MRIYEREYFGGQMSELMGDC CRG1_CHICO 90 18 -
LVIFEKENFIGRQRELCDDY CB31_RANCA 126 23 -
LVIFEKENFIGRQRELCDDY CB32_RANCA 126 23 -
MTIFEKENFIGRQWEISDDY CRBA_HUMAN 126 23 -
LVIFEKENFVGPQWELCDDY CB12_RANCA 109 23 -
ITIFEKENFIGRQWEICDDY CRBA_BOVIN 125 23 -
LVIFEKENFIGRQWEMCDDY CRBA_RANTE 109 23 -
MRIYERDNFGGQMHEVMDDC CRG1_CYPCA 93 21 -
ITVYEKDNFIGRQWEISDDY CRBA_CHICK 126 23 -
LVIFEKENFIGRQWELRDDY CB11_RANCA 109 23 -
LTIFEQENFLGRKGELSDDY CRBD_BOVIN 120 23 -
LRMYERENYMGQMMDVTEDC Q90362 92 19 -
ITNFEKENFIGRQWEICDDY CRBA_MOUSE 109 23 -
MRIYERENFMGQMYEMADDC CRG2_CYPCA 90 18 -
MRIYERENFGGQMYDLTDDC CRG3_CYPCA 89 17 -
LHLFENPAFGGRKMEIVDDD CRB3_BOVIN 115 20 -
LLLFEQENFQGRRGELSDDC CRBD_CHICK 107 23 -
MRIYERENFQGQNHELMNDC Q31555 90 17 -
LTIFEQENFLGKKGELSDDY CRBD_HUMAN 106 23 -
LQIFEKGDFNGQMHETTEDC CRBS_BOVIN 95 19 -
LTIFEQENFLGRKGELSDDY CRBD_RAT 106 23 -
IHLFENAGYTGRKMEIVDDD CRB3_CHICK 116 20 -
IQIFEKGDFSGQMYETTEDC CRBS_HUMAN 95 19 -
MRLYPRENFMGQMMEMSDDC Q90360 91 18 -
IQVFEKGDFNGQMYETTEDC O35486 96 19 -
LHLFENPAFSGRKMDIVDDD CRB3_HUMAN 116 20 -
MKVYERENFNGSRQMDVMDD Q90363 92 19 -
LHLFENPAFSGRKMEIVDDD CRB3_RAT 116 20 -
LCLFEGANFKGNTMEIQEDD CRB1_BOVIN 151 20 -
IVLYENPNFTGKKIEIIDDD CRB2_RANCA 108 20 -
TTMYRRENSMAQMMDVIEDC Q90361 92 19 -
IILYENPNFTGKKMEIIDDD CRB2_HUMAN 108 20 -
IILYENPNFTGKKMEIVDDD CRB2_MOUSE 108 20 -
ICLFEGANFKGNTMEIQEDD CRB1_RAT 147 20 -
VTLFEGENFQGCKFELNDDY CRBB_BOVIN 107 23 -
ITLYENPNFTGKKMEVIDDD CRB2_BOVIN 108 20 -
AILYEAENFQGHKFELSDDY CRBB_CHICK 107 23 -
ISLYESADFKGNKMDIQEDD CRB1_CHICK 138 20 -
ISLFEGANFKGNTIEIQGDD CRB1_HUMAN 150 20 -
IVLYENPSFTGKKIEIIDDD CRB2_CHICK 122 34 -
IILYENPNFTGKKMDEIVDD CRB2_RAT 108 20 -

Motif 4 width=10
Element Seqn Id St Int Rpt
PGEYRRYLDW CRGB_MOUSE 148 38 -
PGEYRRYLDW CRGB_BOVIN 148 38 -
PGEYRRYLDW CRGB_RAT 148 38 -
PGEYRRYHDW CRGE_RAT 147 38 -
PGEYRRYHDW CRGD_RAT 147 38 -
PGEYRRYHDW CRGD_BOVIN 147 38 -
PGDYRRYHDW CRGF_BOVIN 147 38 -
PGEYRRYHDW CRGE_MOUSE 147 38 -
PGEYRRYHDW CRGD_MOUSE 147 38 -
PGEYRRYSDW CRBS_CHICO 148 38 -
PREYRRYHDW CRGF_RAT 147 38 -
PGEYKKFSDW CRG2_CHICO 148 38 -
PGDYRRYHDW CRGA_MOUSE 147 38 -
PGEYRRFLDW CRGB_HUMAN 148 38 -
PGDYRRYHDW CRGA_RAT 147 38 -
PQEYRRFQDW CRGC_MOUSE 147 38 -
PQEYRRYHDW CRGC_RAT 147 38 -
PQEYRRCQDW CRGC_HUMAN 147 38 -
PGEYRRYSDW CRBT_CHICO 148 38 -
LGDYRRYHDW CRGA_HUMAN 147 38 -
PQEYRRYQDW CRGE_BOVIN 147 38 -
PGDYRRYQDW CRGD_HUMAN 147 38 -
PGEYRRYSDW CRG3_XENLA 149 38 -
PGEYRRYSDW O93615 151 38 -
PGEYRRYNDW CRG1_XENLA 149 38 -
PGEYRKFSDW CRG2_XENLA 149 38 -
PGEYRSFRDM Q31554 152 38 -
PGEYKRFTDW CRG2_RANCA 151 38 -
KGEYRKPVDW CRBS_CYPCA 149 38 -
PGEYRSFRDF Q90364 151 39 -
PGEYKRFTDW CRG1_RANCA 151 38 -
PGEYRRYLDW CRGA_BOVIN 148 38 -
PGEYRSFRDM CRG1_CHICO 148 38 -
GGEYKHWREW CB31_RANCA 189 43 -
GGEYKHWREW CB32_RANCA 189 43 -
GGDYKHWREW CRBA_HUMAN 189 43 -
GGEYKHWREW CB12_RANCA 172 43 -
GGDYKHWREW CRBA_BOVIN 188 43 -
GGEYKHWREW CRBA_RANTE 172 43 -
PGEYRSFRDM CRG1_CYPCA 151 38 -
GGDYKHWREW CRBA_CHICK 189 43 -
GGEYKHWREW CB11_RANCA 172 43 -
SGDYKHFREW CRBD_BOVIN 183 43 -
PGEYRSFRET Q90362 151 39 -
GGDYKHWPEW CRBA_MOUSE 172 43 -
PGEYRSFSNM CRG2_CYPCA 148 38 -
PGEYRSFRDM CRG3_CYPCA 147 38 -
RGEYRHWNEW CRB3_BOVIN 174 39 -
AGEYKHVREW CRBD_CHICK 170 43 -
PGEYRSFRDM Q31555 148 38 -
SGDYKHFREW CRBD_HUMAN 169 43 -
KKEYRKPVDW CRBS_BOVIN 153 38 -
SGDYKHFREW CRBD_RAT 169 43 -
KGEYRHWNEW CRB3_CHICK 175 39 -
KKEYRKPIDW CRBS_HUMAN 153 38 -
PGQYRSYRHM Q90360 150 39 -
KKEYRKPVDW O35486 154 38 -
RGEYRHWNEW CRB3_HUMAN 175 39 -
PGEYRNFRDY Q90363 152 40 -
RGEFRHWNEW CRB3_RAT 175 39 -
PGDFRHWNEW CRB1_BOVIN 210 39 -
KGDYKDSSDF CRB2_RANCA 167 39 -
PGEYRSFRET Q90361 151 39 -
KGDYKDSSDF CRB2_HUMAN 167 39 -
KGDYKDNSDF CRB2_MOUSE 167 39 -
PGDFRHWNEW CRB1_RAT 206 39 -
SGEFRNYSEF CRBB_BOVIN 170 43 -
KGDYKDSGDF CRB2_BOVIN 167 39 -
NGEFKKYSEY CRBB_CHICK 170 43 -
TGDFRHWNEW CRB1_CHICK 197 39 -
PGDFRHWNEW CRB1_HUMAN 209 39 -
KGDYKDSSEF CRB2_CHICK 181 39 -
KGDYKDNSDF CRB2_RAT 167 39 -