| Literature References | 1. ALLEN, J.E., CERRONE, M.C., BEATTY, P.R. AND STEPHENS, R.S.
Cysteine-rich outer membrane proteins of Chlamydia trachomatis display
compensatory sequence changes between biovariants.
MOL.MICROBIOL. 4 1543-1550 (1990).
2. ALLEN, J.E. AND STEPHENS, R.S.
An intermolecular mechanism of T cell help for the production of antibodies
to the bacterial pathogen, Chlamydia trachomatis.
EUR.J.IMMUNOL. 23 1169-1172 (1993).
3. BACHMAIER, K., NEU, N., DE LA MAZA, L.M., PAL, S., HESSEL, A. AND
PENNINGER, J.M.
Chlamydia infections and heart disease linked through antigenic mimicry.
SCIENCE 283 1335-1339 (1999).
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| Documentation | Three cysteine-rich proteins (also believed to be lipoproteins) make up the
extracellular matrix of the Chlamydial outer membrane [1]. They are involved
in the essential structural integrity of both the elementary body (EB) and
recticulate body (RB) phase. As these bacteria lack the peptidoglycan layer
common to most Gram-negative microbes, such proteins are highly important
in the pathogenicity of the organism.
The largest of these is the major outer membrane protein (MOMP), and
constitutes around 60% of the total protein for the membrane [2]. OMP2
is the second largest, with a molecular mass of 58kDa, while the OMP3
protein is ~15kDa [1]. MOMP is believed to elicit the strongest immune
response, and has recently been linked to heart disease through its sequence
similarity to a murine heart-muscle specific alpha myosin [3].
The MOMP family plays a structural role in the outer membrane during the
EB stage of the Chlamydial cell, and different biovars show a small, yet
highly significant, change at peptide charge level [1]. Members of this
family include C.trachomatis, C.pneumoniae, and C.psittaci.
CHLAMIDIAOMP is a 6-element fingerprint that provides a signature for
the Chlamydial major outer membrane protein (MOMP) family. The fingerprint
was derived from an initial alignment of 7 sequences: the motifs were drawn
from conserved regions spanning the full alignment length (~500 amino acids).
Two iterations on SPTR37_10f were required to reach convergence, at which
point a true set comprising 40 sequences was identified.
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| Sequence Titles | O06020 MAJOR OUTER MEMBRANE PROTEIN - CHLAMYDIA TRACHOMATIS.
O69088 MAJOR OUTER MEMBRANE PROTEIN - CHLAMYDIA TRACHOMATIS.
O69089 MAJOR OUTER MEMBRANE PROTEIN - CHLAMYDIA TRACHOMATIS.
O69090 MAJOR OUTER MEMBRANE PROTEIN - CHLAMYDIA TRACHOMATIS.
O69091 MAJOR OUTER MEMBRANE PROTEIN - CHLAMYDIA TRACHOMATIS.
O69092 MAJOR OUTER MEMBRANE PROTEIN - CHLAMYDIA TRACHOMATIS.
O69093 MAJOR OUTER MEMBRANE PROTEIN - CHLAMYDIA TRACHOMATIS.
O69094 MAJOR OUTER MEMBRANE PROTEIN - CHLAMYDIA TRACHOMATIS.
O69095 MAJOR OUTER MEMBRANE PROTEIN - CHLAMYDIA TRACHOMATIS.
OMP1_CHLPN MAJOR OUTER MEMBRANE PROTEIN PRECURSOR (MOMP) - CHLAMYDIA PNEUMONIAE (CHLAMYDOPHILA PNEUMONIAE).
OMP1_CHLPS MAJOR OUTER MEMBRANE PROTEIN PRECURSOR (MOMP) - CHLAMYDIA PSITTACI.
OMP2_CHLPS MAJOR OUTER MEMBRANE PROTEIN PRECURSOR (MOMP) - CHLAMYDIA PSITTACI.
OMP3_CHLPS MAJOR OUTER MEMBRANE PROTEIN PRECURSOR (MOMP) - CHLAMYDIA PSITTACI.
OMPA_CHLTR MAJOR OUTER MEMBRANE PROTEIN, SEROVAR A PRECURSOR (MOMP) - CHLAMYDIA TRACHOMATIS.
OMPB_CHLTR MAJOR OUTER MEMBRANE PROTEIN, SEROVAR B PRECURSOR (MOMP) - CHLAMYDIA TRACHOMATIS.
OMPC_CHLTR MAJOR OUTER MEMBRANE PROTEIN, SEROVAR C PRECURSOR (MOMP) - CHLAMYDIA TRACHOMATIS.
OMPE_CHLTR MAJOR OUTER MEMBRANE PROTEIN, SEROVAR E PRECURSOR (MOMP) - CHLAMYDIA TRACHOMATIS.
OMPF_CHLTR MAJOR OUTER MEMBRANE PROTEIN, SEROVAR F PRECURSOR (MOMP) - CHLAMYDIA TRACHOMATIS.
OMPH_CHLTR MAJOR OUTER MEMBRANE PROTEIN, SEROVAR H PRECURSOR (MOMP) - CHLAMYDIA TRACHOMATIS.
OMPL_CHLTR MAJOR OUTER MEMBRANE PROTEIN, SEROVAR L1 PRECURSOR (MOMP) - CHLAMYDIA TRACHOMATIS.
OMPM_CHLTR MAJOR OUTER MEMBRANE PROTEIN, SEROVAR L2 PRECURSOR (MOMP) - CHLAMYDIA TRACHOMATIS.
OMPN_CHLTR MAJOR OUTER MEMBRANE PROTEIN PRECURSOR, SEROVAR L3 (MOMP) - CHLAMYDIA TRACHOMATIS.
P75024 MAJOR OUTER MEMBRANE PROTEIN PRECURSOR - CHLAMYDIA TRACHOMATIS.
Q04063 MAJOR OUTER MEMBRANE PROTEIN PRECURSOR (MOMP) - CHLAMYDIA TRACHOMATIS.
Q07430 MAJOR OUTER MEMBRANE PROTEIN PRECURSOR (MOMP) - CHLAMYDIA PNEUMONIAE.
Q08085 MAJOR OUTER MEMBRANE PROTEIN PRECURSOR (MOMP) - CHLAMYDIA PSITTACI.
Q46193 MAJOR OUTER MEMBRANE PROTEIN PRECURSOR - CHLAMYDIA PSITTACI.
Q46203 MAJOR OUTER MEMBRANE PROTEIN PRECURSOR - CHLAMYDIA PSITTACI.
Q46235 MAJOR OUTER MEMBRANE PROTEIN PRECURSOR - CHLAMYDIA PSITTACI.
Q46236 MAJOR OUTER MEMBRANE PROTEIN PRECURSOR - CHLAMYDIA PSITTACI.
Q46406 MAJOR OUTER MEMBRANE PROTEIN - CHLAMYDIA TRACHOMATIS.
Q46407 MAJOR OUTER MEMBRANE PROTEIN PRECURSOR - CHLAMYDIA TRACHOMATIS.
Q46408 MAJOR OUTER MEMBRANE PROTEIN SEROVAR B PRECURSOR - CHLAMYDIA TRACHOMATIS.
Q46409 MAJOR OUTER MEMBRANE PROTEIN (MOMP) PRECURSOR (MOMP) - CHLAMYDIA TRACHOMATIS.
Q46410 MAJOR OUTER MEMBRANE PROTEIN (MOMP) PRECURSOR (MOMP) - CHLAMYDIA TRACHOMATIS.
Q46411 (INDIVIDUAL ISOLATE 98) - CHLAMYDIA TRACHOMATIS.
Q46412 MAJOR OUTER MEMBRANE PROTEIN (MOMP) PRECURSOR (MOMP) - CHLAMYDIA TRACHOMATIS.
Q46413 (INDIVIDUAL ISOLATE 115) - CHLAMYDIA TRACHOMATIS.
Q46414 MAJOR OUTER MEMBRANE PROTEIN (MOMP) PRECURSOR (MOMP) - CHLAMYDIA TRACHOMATIS.
Q46415 MAJOR OUTER MEMBRANE PROTEIN (MOMP) - CHLAMYDIA TRACHOMATIS.
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