Identifier | INTRLEUKIN10  [View Relations]  [View Alignment]  
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Accession | PR01294 |
No. of Motifs | 4 |
Creation Date | 08-MAR-2000 |
Title | Interleukin-10 signature |
Database References | PROSITE; PS00520 INTERLEUKIN_10 BLOCKS; BL00520 PFAM; PF00726 IL10 PDB; 1ILK SCOP; 1ILK CATH; 1ILK
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Literature References | 1. NICOLA N.A.
Interleukin-10 (IL-10).
IN GUIDEBOOK TO CYTOKINES AND THEIR RECEPTORS (NEW YORK), 1994, PP.83-85
2. ZDANOV A., SCHALK-HIHI C., GUSTCHINA A., TSANG M., WEATHERBEE J.
AND WLODAWER A.
Crystal structure of interleukin-10 reveals the functional dimer with an
unexpected topological similarity to interferon gamma.
STRUCTURE 3 591-601 (1995).
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Documentation | Interleukin 10 (IL-10) is a secreted 17-21kDa protein that is non-
glycosylated in humans but exists as a non-covalent homodimer. IL-10 is
secreted by some types of T-lymphocyte, B-lymphocytes and macrophages late
after antigen activation.
Generally, IL-10 inhibits T-cell and natural killer cell synthesis of other
cytokines at the transcriptional level, indirectly, by affecting
macrophages. These cytokines include interferon-gamma, IL-2, IL-3, tumour
necrosis factor and granulocyte-macrophage colony-stimulating factor
(GM-CSF). The mechanism of IL-10 induced inhibition appears to involve a
reduction in the abundance of the macrophage surface molecules that directly
stimulate T-cells and natural killer cells [1].
Proteins encoded by viruses such as Epstein-Barr virus and equine herpes
virus show a high degree of sequence identity to IL-10. These proteins are
thought to be involved in evasion of host immune responses. The IL-10
molecule is a tight dimer of 2 interpenetrating subunits that form a
V-shaped structure. Each half of the structure consists of 6 alpha-helices
(4 from 1 subunit and 2 from the other). Four of the helices form an
up-up-down-down bundle, which is observed in all other helical cytokines.
The overall topology resembles interferon-gamma [2].
INTRLEUKIN10 is a 4-element fingerprint that provides a signature for
interleukin-10. The fingerprint was derived from an initial alignment of 6
sequences: the motifs were drawn from conserved regions spanning the full
alignment length - motif 1 spans alpha-helix 1; motif 2 contains helix 3 and
the preceding loop; motif 3 contains helix 7 and the preceding loop; and
motif 4 spans helix 9 and the N-terminal portion of helix 10. Two iterations
on SPTR37_10f were required to reach convergence, at which point a true set
comprising 21 sequences was identified.
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Summary Information | 21 codes involving 4 elements 0 codes involving 3 elements 0 codes involving 2 elements
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Composite Feature Index | |
True Positives | BCRF_EBV I10H_HSVE2 IL10_BOVIN IL10_CANFA IL10_CEREL IL10_CERTO IL10_FELCA IL10_HORSE IL10_HUMAN IL10_MACFA IL10_MACMU IL10_MACNE IL10_MERUN IL10_MOUSE IL10_PIG IL10_RAT IL10_SHEEP O11386 O11387 O97798 Q9Z1Y5 |
Sequence Titles | BCRF_EBV BCRF1 PROTEIN PRECURSOR (20 KD PROTEIN) - EPSTEIN-BARR VIRUS (STRAIN B95-8) (HUM I10H_HSVE2 INTERLEUKIN-10 HOMOLOG PRECURSOR - EQUINE HERPESVIRUS TYPE 2 (STRAIN 86/87) (EHV IL10_BOVIN INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - IL10_CANFA INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - IL10_CEREL INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - IL10_CERTO INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - IL10_FELCA INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - IL10_HORSE INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - IL10_HUMAN INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - IL10_MACFA INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - IL10_MACMU INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - IL10_MACNE INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - IL10_MERUN INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - IL10_MOUSE INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - IL10_PIG INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - IL10_RAT INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - IL10_SHEEP INTERLEUKIN-10 PRECURSOR (IL-10) (CYTOKINE SYNTHESIS INHIBITORY FACTOR) (CSIF) - O11386 INTERLEUKIN-10 - ORF VIRUS. O11387 PUTATIVE INTERLEUKIN-10 - ORF VIRUS. O97798 INTERLEUKIN-10 - TRICHOSURUS VULPECULA (BRUSH-TAILED POSSUM). Q9Z1Y5 INTERLEUKIN 10 - CAVIA PORCELLUS (GUINEA PIG).
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Scan History | SPTR37_10f 2 200 NSINGLE
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Initial Motifs | Motif 1 width=17 Element Seqn Id St Int Rpt MLRDLRDAFSRVKTFFQ IL10_MACNE 40 40 - MLRDLRDAFSRVKTFFQ BCRF_EBV 33 33 - MLRDLRDAFSRVKTFFQ IL10_HUMAN 40 40 - MLRELRAAFGRVKIFFQ IL10_CANFA 41 41 - MLLELRTAFSQVKTFFQ IL10_MOUSE 40 40 - MLRELRAAFSSVKTYFQ O97798 36 36 - Motif 2 width=17 Element Seqn Id St Int Rpt KGYLGCQALSEMIQFYL IL10_MACNE 75 18 - KGYLGCQALSEMIQFYL BCRF_EBV 68 18 - KGYLGCQALSEMIQFYL IL10_HUMAN 75 18 - KSYLGCQALSEMIQFYL IL10_CANFA 76 18 - KGYLGCQALSEMIQFYL IL10_MOUSE 75 18 - KSYLGCQALSEMIKFYL O97798 71 18 - Motif 3 width=10 Element Seqn Id St Int Rpt RRCHRFLPCE IL10_MACNE 124 32 - RRCHRFLPCE BCRF_EBV 117 32 - RRCHRFLPCE IL10_HUMAN 124 32 - RRCHRFLPCE IL10_CANFA 127 34 - RRCHRFLKCE IL10_MOUSE 124 32 - KRCHRFLPCE O97798 120 32 - Motif 4 width=17 Element Seqn Id St Int Rpt LQEKGVYKAMSEFDIFI IL10_MACNE 149 15 - LQEKGIYKAMSEFDIFI BCRF_EBV 142 15 - LQEKGIYKAMSEFDIFI IL10_HUMAN 149 15 - LQEKGVYKAMSEFDIFI IL10_CANFA 152 15 - LEDQGVYKAMNEFDIFI IL10_MOUSE 149 15 - LQEQGVYKAMGDFDIFI O97798 145 15 -
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Final Motifs | Motif 1 width=17 Element Seqn Id St Int Rpt MLRDLRDAFSRVKTFFQ IL10_MACFA 40 40 - MLRDLRDAFSRVKTFFQ IL10_MACNE 40 40 - MLRDLRDAFSRVKTFFQ IL10_MACMU 40 40 - MLHELRAAFSRVKTFFQ I10H_HSVE2 40 40 - MLHELRAAFSRVKTFFQ IL10_HORSE 40 40 - MLRELRAAFSQVKTFFQ IL10_MERUN 40 40 - MLRELRAAFGKVKTFFQ O11386 50 50 - MLRELRAAFGKVKTFFQ O11387 50 50 - MLRDLRDAFSRVKTFFQ BCRF_EBV 33 33 - MLRDLRDAFSRVKTFFQ IL10_HUMAN 40 40 - MLRDLRDVFSRVKTFFQ IL10_CERTO 40 40 - MLRELRTAFSRVKNFFQ IL10_CEREL 41 41 - MLRELRAAFGRVKTFFQ Q9Z1Y5 40 40 - MLRELRAAFGRVKIFFQ IL10_CANFA 41 41 - MLXELRAAFGKVKTFFQ IL10_FELCA 40 40 - MLRELRAAFGEAKTFFQ IL10_BOVIN 40 40 - MLRDVRAAFGKVKTFFQ IL10_SHEEP 41 41 - MLRELRAAFSQVKTFFQ IL10_RAT 40 40 - MLRELRAAFGPVKSFFQ IL10_PIG 36 36 - MLLELRTAFSQVKTFFQ IL10_MOUSE 40 40 - MLRELRAAFSSVKTYFQ O97798 36 36 - Motif 2 width=17 Element Seqn Id St Int Rpt KGYLGCQALSEMIQFYL IL10_MACFA 75 18 - KGYLGCQALSEMIQFYL IL10_MACNE 75 18 - KGYLGCQALSEMIQFYL IL10_MACMU 75 18 - KGYLGCQALSEMIQFYL I10H_HSVE2 75 18 - KGYLGCQALSEMIQFYL IL10_HORSE 75 18 - KGYLGCQALSEMIQFYL IL10_MERUN 75 18 - KGYLGCQALSEMIQFYL O11386 85 18 - KGYLGCQALSEMIQFYL O11387 85 18 - KGYLGCQALSEMIQFYL BCRF_EBV 68 18 - KGYLGCQALSEMIQFYL IL10_HUMAN 75 18 - KGYLGCQALSEMIQFYL IL10_CERTO 75 18 - KGYLGCQALSEMIQFYL IL10_CEREL 76 18 - KGYLGCQALSEMIQFYL Q9Z1Y5 75 18 - KSYLGCQALSEMIQFYL IL10_CANFA 76 18 - KGYLGCQALSEMIQFYL IL10_FELCA 75 18 - KGYLGCQALSEMIQFYL IL10_BOVIN 75 18 - KGYLGCQALSEMIQFYL IL10_SHEEP 76 18 - KGYLGCQALSEMIKFYL IL10_RAT 75 18 - KGYLGCQALSEMIQFYL IL10_PIG 71 18 - KGYLGCQALSEMIQFYL IL10_MOUSE 75 18 - KSYLGCQALSEMIKFYL O97798 71 18 - Motif 3 width=10 Element Seqn Id St Int Rpt RRCHRFLPCE IL10_MACFA 124 32 - RRCHRFLPCE IL10_MACNE 124 32 - RRCHRFLPCE IL10_MACMU 124 32 - RRCHRFLPCE I10H_HSVE2 125 33 - RRCHRFLPCE IL10_HORSE 124 32 - RRCHRFLPCE IL10_MERUN 124 32 - RRCHRFLPCE O11386 134 32 - RRCHRFLPCE O11387 134 32 - RRCHRFLPCE BCRF_EBV 117 32 - RRCHRFLPCE IL10_HUMAN 124 32 - RRCHRFLPCE IL10_CERTO 124 32 - RRCHRFLPCE IL10_CEREL 125 32 - RRCHRFLPCE Q9Z1Y5 124 32 - RRCHRFLPCE IL10_CANFA 127 34 - RRCHRFLPCE IL10_FELCA 124 32 - RRCHRFLPCE IL10_BOVIN 124 32 - RRCHRFLPCE IL10_SHEEP 125 32 - RRCHRFLPCE IL10_RAT 124 32 - RRCHQFLPCE IL10_PIG 120 32 - RRCHRFLKCE IL10_MOUSE 124 32 - KRCHRFLPCE O97798 120 32 - Motif 4 width=17 Element Seqn Id St Int Rpt LQEKGVYKAMSEFDIFI IL10_MACFA 149 15 - LQEKGVYKAMSEFDIFI IL10_MACNE 149 15 - LQEKGVYKAMSEFDIFI IL10_MACMU 149 15 - LQEKGVYKAMSEFDIFI I10H_HSVE2 150 15 - LQEKGVYKAMSEFDIFI IL10_HORSE 149 15 - LQEKGVYKAMNEFDIFI IL10_MERUN 149 15 - LQERGVYKAMSEFDIFI O11386 159 15 - LQERGVYKAMSEFDIFI O11387 159 15 - LQEKGIYKAMSEFDIFI BCRF_EBV 142 15 - LQEKGIYKAMSEFDIFI IL10_HUMAN 149 15 - LQEKGVYKAMSEFDIFI IL10_CERTO 149 15 - LQERGVYKAMSEFDIFI IL10_CEREL 150 15 - LQDQGVYKAMNEFDIFI Q9Z1Y5 149 15 - LQEKGVYKAMSEFDIFI IL10_CANFA 152 15 - LQEKGVYKAMGEFDIFI IL10_FELCA 149 15 - LQERGVYKAMSEFDIFI IL10_BOVIN 149 15 - LQERGVYKAMSEFDIFI IL10_SHEEP 150 15 - LQDKGVYKAMNEFDIFI IL10_RAT 149 15 - LQERGVYKAMGEFDIFI IL10_PIG 145 15 - LEDQGVYKAMNEFDIFI IL10_MOUSE 149 15 - LQEQGVYKAMGDFDIFI O97798 145 15 -
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