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PR01145

Identifier
TSHRECEPTOR  [View Relations]  [View Alignment]  
Accession
PR01145
No. of Motifs
15
Creation Date
21-MAR-1999
Title
Thyrotropin receptor precursor signature 
Database References
PRINTS; PR90007 7TM; PR90006 GPCRCLAN; PR00237 GPCRRHODOPSN
PRINTS; PR00373 GLYCHORMONER
INTERPRO; IPR002274
GCRDB; GCR_1225; GCR_2587; GCR_0020; GCR_0021; GCR_0022; GCR_0224

GCRDB; GCR_0163
Literature References
1. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
 
2. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
G protein-coupled receptor fingerprints.
7TM, VOLUME 2, EDS. G.VRIEND AND B.BYWATER (1993).
 
3. BIRNBAUMER, L.
G proteins in signal transduction.
ANNU.REV.PHARMACOL.TOXICOL. 30 675-705 (1990).
 
4. CASEY, P.J. AND GILMAN, A.G.
G protein involvement in receptor-effector coupling.
J.BIOL.CHEM. 263(6) 2577-2580 (1988).
 
5. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Design of a discriminating fingerprint for G protein-coupled receptors.
PROTEIN ENG. 6(2) 167-176 (1993).
 
6. WATSON, S. AND ARKINSTALL, S.
Glycoprotein hormones.
In THE G-PROTEIN-LINKED RECEPTOR FACTSBOOK, ACADEMIC PRESS, 1994, pp142-149.
 
7. JIANG, X., DREANO, M., BUCKLER, D.R., CHENG, S., YTHIER, A., WU, H.,
HENDRICKSON, W.A. AND EL TAYAR, N.
Structural predictions for the ligand-binding region of glycoprotein hormone
receptors and the nature of hormone-receptor interactions.
STRUCTURE 3 1341-1353 (1995).
 
8. KOPP, P., MUIRHEAD, S., JOURDAIN, N., GU, W.X., JAMESON, J.L. 
AND RODD, C.
Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a
novel somatic mutation (serine281-->isoleucine) in the extracellular domain 
of the thyrotropin receptor
J.CLIN.INVEST. 100 1634-1639 (1997). 

Documentation
G protein-coupled receptors (GPCRs) constitute a vast protein family that 
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the 
sequence level, on the basis of which they can be separated into distinct 
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship, 
but between which there is no statistically significant similarity in 
sequence [1]. The currently known clan members include the rhodopsin-like 
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
 
The rhodopsin-like GPCRs themselves represent a widespread protein family 
that includes hormone, neurotransmitter and light receptors, all of
which transduce extracellular signals through interaction with guanine
nucleotide-binding (G) proteins. Although their activating ligands vary 
widely in structure and character, the amino acid sequences of the 
receptors are very similar and are believed to adopt a common structural 
framework comprising 7 transmembrane (TM) helices [3-5]. 
 
The gonadotrophins (luteinising hormone, choriogonadotrophin, follicle-
stimulating hormone) and thyroid-stimulating hormone are heterotrimeric
glycoproteins composed of a common alpha-subunit and distinct beta-subunits
[6]. The carbohydrate moiety of the glycoproteins has an essential role in
receptor recognition. The receptors share close sequence similarity, and
are characterised by large extracellular domains believed to be involved
in hormone binding via leucine-rich repeats (LRR) [7]. Modelling of this
portion of the receptors suggests that they contain three-dimensional
structures similar to that of porcine ribonuclease inhibitor [7].
 
TSHR (also known as thyrotrophin) is synthesised in the thyrotroph cells of
the anterior pituitary under the influence of TRH and thyroid hormones [6].
It acts on the thyroid gland, stimulating iodine uptake, synthesis and
release of thyroid hormones, hypertrophy and hyperplasia [6]. Graves disease
is caused by stimulatory anti-TSH receptor antibodies [6]. The receptor is
found in thyroid follicular cells and related cell lines, its predominant
effector pathway being via activation of adenylyl cyclase through Gs [6]. 
 
Activating somatic mutations in the TSH receptor have been identified as a
cause of hyperfunctioning thyroid adenomas, and germline mutations have been
found in familial non-autoimmune hyperthyroidism and sporadic congenital
hyperthyroidism [8]. To date, all reported mutations have been located in
the TM domain. Now, an example of an activating mutation in the extra-
cellular, TSH-binding domain, has been found in a male infant with
congenital hyperthyroidism due to a toxic adenoma [8]. The results indicate
that activating mutations can also occur in the extracellular domain of the
TSH receptor, and support a model in which this domain serves to restrain
receptor function in the absence of TSH or antibody-induced conformational
changes [8]. 
 
TSHRECEPTOR is a 15-element fingerprint that provides a signature for the
thyrotropin receptors. The fingerprint was derived from an initial alignment
of 6 sequences: the motifs were drawn from conserved regions spanning 
virtually the full alignment length, focusing on those sections that 
characterise the TSH receptors but distinguish them from the rest of the
glycoprotein hormone receptor family - motifs 1-13 reside within the 
N-terminal half of the alignment, prior to the TM domains; and motifs 14 and
15 lie at the C-terminus. A single iteration on SPTR37_9f was required to
reach convergence, no further sequences being identfied beyond the starting
set. Three partial matches were found, all of which are thyrotropin receptor
variants.
Summary Information
   6 codes involving 15 elements
0 codes involving 14 elements
0 codes involving 13 elements
0 codes involving 12 elements
0 codes involving 11 elements
0 codes involving 10 elements
0 codes involving 9 elements
0 codes involving 8 elements
2 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
1 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
15666666666666666
14000000000000000
13000000000000000
12000000000000000
11000000000000000
10000000000000000
9000000000000000
8000000000000000
7222222200000000
6000000000000000
5000000000000000
4000000000000000
3111111111111100
2000000000000000
123456789101112131415
True Positives
TSHR_BOVIN    TSHR_CANFA    TSHR_HUMAN    TSHR_MOUSE    
TSHR_RAT TSHR_SHEEP
True Positive Partials
Codes involving 7 elements
O35517 Q16503
Codes involving 3 elements
Q27986
Sequence Titles
TSHR_BOVIN  Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormone receptor) - Bos taurus (Bovine). 
TSHR_CANFA Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormone receptor) - Canis familiaris (Dog).
TSHR_HUMAN Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormone receptor) - Homo sapiens (Human).
TSHR_MOUSE Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormone receptor) - Mus musculus (Mouse).
TSHR_RAT Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormone receptor) - Rattus norvegicus (Rat).
TSHR_SHEEP Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormone receptor) - Ovis aries (Sheep).

O35517 TRUNCATED TSH RECEPTOR - RATTUS SORDIDUS (AUSTRALIAN DUSKY FIELD RAT).
Q16503 THYROTROPIN RECEPTOR-I - HOMO SAPIENS (HUMAN).

Q27986 THYROTROPIN (TSH) RECEPTOR VARIANT (TSH) - BOS TAURUS (BOVINE).
Scan History
SPTR37_9f  1  9    NSINGLE    
Initial Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
RPADLLQLVLLLDLPRDLGG TSHR_HUMAN 2 2 -
RPGSLLQLTLLLALPRSLWG TSHR_RAT 2 2 -
RPTPLLRLALLLVLPSSLWG TSHR_SHEEP 2 2 -
RPTPLLRLALFLVLPSSLGG TSHR_BOVIN 2 2 -
RPPPLLHLALLLALPRSLGG TSHR_CANFA 2 2 -
RPGSLLLLVLLLALSRSLRG TSHR_MOUSE 2 2 -

Motif 2 width=20
Element Seqn Id St Int Rpt
CTSPPCECHQEDDFRVTCKE TSHR_RAT 24 2 -
CPSPPCECRQEDDFRVTCKD TSHR_BOVIN 24 2 -
CPSPPCECRQEDDFRVTCKD TSHR_SHEEP 24 2 -
CPSPPCECHQEDDFRVTCKD TSHR_CANFA 24 2 -
CASPPCECHQEDDFRVTCKE TSHR_MOUSE 24 2 -
CSSPPCECHQEEDFRVTCKD TSHR_HUMAN 24 2 -

Motif 3 width=15
Element Seqn Id St Int Rpt
IPSLPPSTQTLKLIE TSHR_HUMAN 47 3 -
IPSLPPSTQTLKFIE TSHR_SHEEP 47 3 -
IPSLPPSTQTLKLIE TSHR_RAT 47 3 -
IPSLPPSTQTLKFIE TSHR_BOVIN 47 3 -
IPTLPPSTQTLKFIE TSHR_CANFA 47 3 -
IPSLPPSTQTLKLIE TSHR_MOUSE 47 3 -

Motif 4 width=19
Element Seqn Id St Int Rpt
FSNLPNISRIYLSIDATLQ TSHR_CANFA 72 10 -
FSNLPNISRIYLSIDATLQ TSHR_BOVIN 72 10 -
FSNLPNISRIYLSIDATLQ TSHR_SHEEP 72 10 -
FSSLPNISRIYLSIDATLQ TSHR_RAT 72 10 -
FSSLPNISRIYLSIDATLQ TSHR_MOUSE 72 10 -
FSNLPNISRIYVSIDVTLQ TSHR_HUMAN 72 10 -

Motif 5 width=17
Element Seqn Id St Int Rpt
LSKVTHIEIRNTRSLTY TSHR_BOVIN 100 9 -
LSKVTHIEIRNTRSLTY TSHR_SHEEP 100 9 -
LSKMTHIEIRNTRSLTY TSHR_RAT 100 9 -
LSKMTHIEIRNTRSLTS TSHR_CANFA 100 9 -
LSKMTHIEIRNTRSLTY TSHR_MOUSE 100 9 -
LSKVTHIEIRNTRNLTY TSHR_HUMAN 100 9 -

Motif 6 width=19
Element Seqn Id St Int Rpt
GLRVFPDLTKIYSTDVFFI TSHR_BOVIN 137 20 -
GLRVFPDLTKIYSTDVFFI TSHR_SHEEP 137 20 -
GLRIFPDLTKIYSTDVFFI TSHR_RAT 137 20 -
GLGVFPDVTKVYSTDVFFI TSHR_CANFA 137 20 -
GLRIFPDLTKIYSTDIFFI TSHR_MOUSE 137 20 -
GLKMFPDLTKVYSTDIFFI TSHR_HUMAN 137 20 -

Motif 7 width=26
Element Seqn Id St Int Rpt
TKLDAVYLNKNKYLTVIGQDAFAGVY TSHR_BOVIN 200 44 -
TKLDAVYLNKNKYLTVIDQDAFAGVY TSHR_SHEEP 200 44 -
TKLDAVYLNKNKYLTAIDKDAFGGVY TSHR_RAT 200 44 -
TKLDAVYLNKNKYLSAIDKDAFGGVY TSHR_CANFA 200 44 -
TKLDAVYLNKNKYLTAIDNDAFGGVY TSHR_MOUSE 200 44 -
TKLDAVYLNKNKYLTVIDKDAFGGVY TSHR_HUMAN 200 44 -

Motif 8 width=16
Element Seqn Id St Int Rpt
PLSLSFLHLTRADLSY TSHR_CANFA 264 38 -
PLSLSFLHLTRADLSY TSHR_BOVIN 264 38 -
PLSLSFLHLTRADLSY TSHR_SHEEP 264 38 -
PLSLSFLHLTRADLSY TSHR_RAT 264 38 -
PLSLSFLHLTRADLSY TSHR_MOUSE 264 38 -
PLSLSFLHLTRADLSY TSHR_HUMAN 264 38 -

Motif 9 width=17
Element Seqn Id St Int Rpt
KNQKKIRGILQSLMCNE TSHR_BOVIN 287 7 -
KNQKNIRGILQSLMCNE TSHR_SHEEP 287 7 -
KNQKKIRGILESLMCNE TSHR_RAT 287 7 -
KNQKKIRGILESLMCNE TSHR_CANFA 287 7 -
KNQKKIRGILESLMCNE TSHR_MOUSE 287 7 -
KNQKKIRGILESLMCNE TSHR_HUMAN 287 7 -

Motif 10 width=20
Element Seqn Id St Int Rpt
LRQRKSASALNGPFYQEYED TSHR_BOVIN 309 5 -
LRQRKSASALNGPFYQEYEE TSHR_SHEEP 309 5 -
LRQRKSVNVMRGPVYQEYEE TSHR_RAT 309 5 -
LRQRKSVNTLNGPFDQEYEE TSHR_CANFA 309 5 -
LRQRKSVNILRGPIYQEYEE TSHR_MOUSE 309 5 -
LRQRKSVNALNSPLHQEYEE TSHR_HUMAN 309 5 -

Motif 11 width=21
Element Seqn Id St Int Rpt
GDGSAGYKENSKFQDTQSNSH TSHR_BOVIN 330 1 -
GDGSAGYKENSKFQDTHSNSH TSHR_SHEEP 331 2 -
GDNHVGYKQNSKFQEGPSNSH TSHR_RAT 331 2 -
GDSHAGYKDNSQFQDTDSNSH TSHR_CANFA 331 2 -
GDNSVGYKQNSKFQESPSNSH TSHR_MOUSE 331 2 -
GDSIVGYKEKSKFQDTHNNAH TSHR_HUMAN 331 2 -

Motif 12 width=23
Element Seqn Id St Int Rpt
HYYVFFEEQEDEIIGFGQQLKNP TSHR_BOVIN 350 -1 -
HYYVFFEDQEDEIIGFGQELKNP TSHR_SHEEP 351 -1 -
HYYVFFEEQEDEIIGFGQELKNP TSHR_RAT 351 -1 -
HYYVFFEEQEDEILGFGQELKNP TSHR_CANFA 351 -1 -
HYYVFFEEQEDEVVGFGQELKNP TSHR_MOUSE 351 -1 -
HYYVFFEEQEDEIIGFGQELKNP TSHR_HUMAN 351 -1 -

Motif 13 width=16
Element Seqn Id St Int Rpt
QEETLQAFDSHYDYTV TSHR_BOVIN 373 0 -
QEETLQAFDNHYDYTV TSHR_SHEEP 374 0 -
QEETLQAFDSHYDYTV TSHR_RAT 374 0 -
QEETLQAFDSHYDYTV TSHR_CANFA 374 0 -
QEETLQAFESHYDYTV TSHR_MOUSE 374 0 -
QEETLQAFDSHYDYTI TSHR_HUMAN 374 0 -

Motif 14 width=22
Element Seqn Id St Int Rpt
YRGQRVSPKNSTGIRVQKVPPD TSHR_BOVIN 705 316 -
YRGQRVSSKNSTGIRVQKVPPD TSHR_SHEEP 706 316 -
YQAQRVCPNNNTGIQIQKIPQD TSHR_RAT 706 316 -
YRGQRVSPKNSAGIQIQKVTRD TSHR_CANFA 706 316 -
YQGQRVCPNNSTGIQIQKIPQD TSHR_MOUSE 706 316 -
YRGQRVPPKNSTDIQVQKVTHD TSHR_HUMAN 706 316 -

Motif 15 width=26
Element Seqn Id St Int Rpt
DVRQSLPNVQDDYELLENSHLTPKQQ TSHR_BOVIN 726 -1 -
DVRQSLPNVQDDYELLGNSHLTPKQQ TSHR_SHEEP 727 -1 -
DTRQSLPNVQDTYEPLGSSHLTPKLQ TSHR_RAT 727 -1 -
DMRQSLPNMQDEYELLENSHLTPNKQ TSHR_CANFA 727 -1 -
DTRQSLPNMQDTYELLGNSQLAPKLQ TSHR_MOUSE 727 -1 -
DMRQGLHNMEDVYELIENSHLTPKKQ TSHR_HUMAN 727 -1 -
Final Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
RPADLLQLVLLLDLPRDLGG TSHR_HUMAN 2 2 -
RPGSLLQLTLLLALPRSLWG TSHR_RAT 2 2 -
RPTPLLRLALLLVLPSSLWG TSHR_SHEEP 2 2 -
RPTPLLRLALFLVLPSSLGG TSHR_BOVIN 2 2 -
RPPPLLHLALLLALPRSLGG TSHR_CANFA 2 2 -
RPGSLLLLVLLLALSRSLRG TSHR_MOUSE 2 2 -

Motif 2 width=20
Element Seqn Id St Int Rpt
CTSPPCECHQEDDFRVTCKE TSHR_RAT 24 2 -
CPSPPCECRQEDDFRVTCKD TSHR_BOVIN 24 2 -
CPSPPCECRQEDDFRVTCKD TSHR_SHEEP 24 2 -
CPSPPCECHQEDDFRVTCKD TSHR_CANFA 24 2 -
CASPPCECHQEDDFRVTCKE TSHR_MOUSE 24 2 -
CSSPPCECHQEEDFRVTCKD TSHR_HUMAN 24 2 -

Motif 3 width=15
Element Seqn Id St Int Rpt
IPSLPPSTQTLKLIE TSHR_HUMAN 47 3 -
IPSLPPSTQTLKFIE TSHR_SHEEP 47 3 -
IPSLPPSTQTLKLIE TSHR_RAT 47 3 -
IPSLPPSTQTLKFIE TSHR_BOVIN 47 3 -
IPTLPPSTQTLKFIE TSHR_CANFA 47 3 -
IPSLPPSTQTLKLIE TSHR_MOUSE 47 3 -

Motif 4 width=19
Element Seqn Id St Int Rpt
FSNLPNISRIYLSIDATLQ TSHR_CANFA 72 10 -
FSNLPNISRIYLSIDATLQ TSHR_BOVIN 72 10 -
FSNLPNISRIYLSIDATLQ TSHR_SHEEP 72 10 -
FSSLPNISRIYLSIDATLQ TSHR_RAT 72 10 -
FSSLPNISRIYLSIDATLQ TSHR_MOUSE 72 10 -
FSNLPNISRIYVSIDVTLQ TSHR_HUMAN 72 10 -

Motif 5 width=17
Element Seqn Id St Int Rpt
LSKVTHIEIRNTRSLTY TSHR_BOVIN 100 9 -
LSKVTHIEIRNTRSLTY TSHR_SHEEP 100 9 -
LSKMTHIEIRNTRSLTY TSHR_RAT 100 9 -
LSKMTHIEIRNTRSLTS TSHR_CANFA 100 9 -
LSKMTHIEIRNTRSLTY TSHR_MOUSE 100 9 -
LSKVTHIEIRNTRNLTY TSHR_HUMAN 100 9 -

Motif 6 width=19
Element Seqn Id St Int Rpt
GLRVFPDLTKIYSTDVFFI TSHR_BOVIN 137 20 -
GLRVFPDLTKIYSTDVFFI TSHR_SHEEP 137 20 -
GLRIFPDLTKIYSTDVFFI TSHR_RAT 137 20 -
GLGVFPDVTKVYSTDVFFI TSHR_CANFA 137 20 -
GLRIFPDLTKIYSTDIFFI TSHR_MOUSE 137 20 -
GLKMFPDLTKVYSTDIFFI TSHR_HUMAN 137 20 -

Motif 7 width=26
Element Seqn Id St Int Rpt
TKLDAVYLNKNKYLTVIGQDAFAGVY TSHR_BOVIN 200 44 -
TKLDAVYLNKNKYLTVIDQDAFAGVY TSHR_SHEEP 200 44 -
TKLDAVYLNKNKYLTAIDKDAFGGVY TSHR_RAT 200 44 -
TKLDAVYLNKNKYLSAIDKDAFGGVY TSHR_CANFA 200 44 -
TKLDAVYLNKNKYLTAIDNDAFGGVY TSHR_MOUSE 200 44 -
TKLDAVYLNKNKYLTVIDKDAFGGVY TSHR_HUMAN 200 44 -

Motif 8 width=16
Element Seqn Id St Int Rpt
PLSLSFLHLTRADLSY TSHR_CANFA 264 38 -
PLSLSFLHLTRADLSY TSHR_BOVIN 264 38 -
PLSLSFLHLTRADLSY TSHR_SHEEP 264 38 -
PLSLSFLHLTRADLSY TSHR_RAT 264 38 -
PLSLSFLHLTRADLSY TSHR_MOUSE 264 38 -
PLSLSFLHLTRADLSY TSHR_HUMAN 264 38 -

Motif 9 width=17
Element Seqn Id St Int Rpt
KNQKKIRGILQSLMCNE TSHR_BOVIN 287 7 -
KNQKNIRGILQSLMCNE TSHR_SHEEP 287 7 -
KNQKKIRGILESLMCNE TSHR_RAT 287 7 -
KNQKKIRGILESLMCNE TSHR_CANFA 287 7 -
KNQKKIRGILESLMCNE TSHR_MOUSE 287 7 -
KNQKKIRGILESLMCNE TSHR_HUMAN 287 7 -

Motif 10 width=20
Element Seqn Id St Int Rpt
LRQRKSASALNGPFYQEYED TSHR_BOVIN 309 5 -
LRQRKSASALNGPFYQEYEE TSHR_SHEEP 309 5 -
LRQRKSVNVMRGPVYQEYEE TSHR_RAT 309 5 -
LRQRKSVNTLNGPFDQEYEE TSHR_CANFA 309 5 -
LRQRKSVNILRGPIYQEYEE TSHR_MOUSE 309 5 -
LRQRKSVNALNSPLHQEYEE TSHR_HUMAN 309 5 -

Motif 11 width=21
Element Seqn Id St Int Rpt
GDGSAGYKENSKFQDTQSNSH TSHR_BOVIN 330 1 -
GDGSAGYKENSKFQDTHSNSH TSHR_SHEEP 331 2 -
GDNHVGYKQNSKFQEGPSNSH TSHR_RAT 331 2 -
GDSHAGYKDNSQFQDTDSNSH TSHR_CANFA 331 2 -
GDNSVGYKQNSKFQESPSNSH TSHR_MOUSE 331 2 -
GDSIVGYKEKSKFQDTHNNAH TSHR_HUMAN 331 2 -

Motif 12 width=23
Element Seqn Id St Int Rpt
HYYVFFEEQEDEIIGFGQQLKNP TSHR_BOVIN 350 -1 -
HYYVFFEDQEDEIIGFGQELKNP TSHR_SHEEP 351 -1 -
HYYVFFEEQEDEIIGFGQELKNP TSHR_RAT 351 -1 -
HYYVFFEEQEDEILGFGQELKNP TSHR_CANFA 351 -1 -
HYYVFFEEQEDEVVGFGQELKNP TSHR_MOUSE 351 -1 -
HYYVFFEEQEDEIIGFGQELKNP TSHR_HUMAN 351 -1 -

Motif 13 width=16
Element Seqn Id St Int Rpt
QEETLQAFDSHYDYTV TSHR_BOVIN 373 0 -
QEETLQAFDNHYDYTV TSHR_SHEEP 374 0 -
QEETLQAFDSHYDYTV TSHR_RAT 374 0 -
QEETLQAFDSHYDYTV TSHR_CANFA 374 0 -
QEETLQAFESHYDYTV TSHR_MOUSE 374 0 -
QEETLQAFDSHYDYTI TSHR_HUMAN 374 0 -

Motif 14 width=22
Element Seqn Id St Int Rpt
YRGQRVSPKNSTGIRVQKVPPD TSHR_BOVIN 705 316 -
YRGQRVSSKNSTGIRVQKVPPD TSHR_SHEEP 706 316 -
YQAQRVCPNNNTGIQIQKIPQD TSHR_RAT 706 316 -
YRGQRVSPKNSAGIQIQKVTRD TSHR_CANFA 706 316 -
YQGQRVCPNNSTGIQIQKIPQD TSHR_MOUSE 706 316 -
YRGQRVPPKNSTDIQVQKVTHD TSHR_HUMAN 706 316 -

Motif 15 width=26
Element Seqn Id St Int Rpt
DVRQSLPNVQDDYELLENSHLTPKQQ TSHR_BOVIN 726 -1 -
DVRQSLPNVQDDYELLGNSHLTPKQQ TSHR_SHEEP 727 -1 -
DTRQSLPNVQDTYEPLGSSHLTPKLQ TSHR_RAT 727 -1 -
DMRQSLPNMQDEYELLENSHLTPNKQ TSHR_CANFA 727 -1 -
DTRQSLPNMQDTYELLGNSQLAPKLQ TSHR_MOUSE 727 -1 -
DMRQGLHNMEDVYELIENSHLTPKKQ TSHR_HUMAN 727 -1 -