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PR01101

Identifier
5HTRECEPTOR  [View Relations]  [View Alignment]  
Accession
PR01101
No. of Motifs
4
Creation Date
03-APR-1999
Title
5-hydroxytryptamine receptor signature
Database References
PRINTS; PR90007 7TM; PR90006 GPCRCLAN; PR00237 GPCRRHODOPSN
PRINTS; PR00512 5HT1ARECEPTR; PR00513 5HT1BRECEPTR; PR00514 5HT1DRECEPTR
PRINTS; PR00515 5HT1FRECEPTR; PR00516 5HT2ARECEPTR; PR00651 5HT2BRECEPTR
PRINTS; PR00517 5HT2CRECEPTR; PR01059 5HT4RECEPTR; PR00518 5HT5ARECEPTR
PRINTS; PR00519 5HT5BRECEPTR; PR01102 5HT6RECEPTR; PR00652 5HT7RECEPTR

INTERPRO; IPR002231
GCRDB; GCR_0087; GCR_0381; GCR_0624; GCR_0109; GCR_0286; GCR_0282

GCRDB; GCR_0311
Literature References
1. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
 
2. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
G protein-coupled receptor fingerprints.
7TM, VOLUME 2, EDS. G.VRIEND AND B.BYWATER (1993).
 
3. BIRNBAUMER, L.
G proteins in signal transduction.
ANNU.REV.PHARMACOL.TOXICOL. 30 675-705 (1990).
 
4. CASEY, P.J. AND GILMAN, A.G.
G protein involvement in receptor-effector coupling.
J.BIOL.CHEM. 263(6) 2577-2580 (1988).
 
5. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Design of a discriminating fingerprint for G protein-coupled receptors.
PROTEIN ENG. 6(2) 167-176 (1993).
 
6. WATSON, S. AND ARKINSTALL, S.
5-Hydroxytryptamine.
IN THE G PROTEIN-LINKED RECEPTOR FACTSBOOK, ACADEMIC PRESS, 1994, PP.159-180.

Documentation
G protein-coupled receptors (GPCRs) constitute a vast protein family that 
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the 
sequence level, on the basis of which they can be separated into distinct 
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship, 
but between which there is no statistically significant similarity in 
sequence [1]. The currently known clan members include the rhodopsin-like 
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
 
The rhodopsin-like GPCRs themselves represent a widespread protein family 
that includes hormone, neurotransmitter and light receptors, all of
which transduce extracellular signals through interaction with guanine
nucleotide-binding (G) proteins. Although their activating ligands vary 
widely in structure and character, the amino acid sequences of the 
receptors are very similar and are believed to adopt a common structural 
framework comprising 7 transmembrane (TM) helices [3-5]. 
 
5-Hydroxytryptamine (or serotonin) is ubiquitous in plants and animals.
It is an important neurotransmitter and local hormone in the CNS and
instestine, and is implicated in a vast array of physiological and patho-
physiological pathways [6]. In the periphery, 5HT contracts a number of
smooth muscles, and induces endothelium-dependent vasodilation through
the formation of NO [6]. It is a mediator of peristalsis, and may be
involved in platelet aggregation and homeostasis. In the CNS, 5HT is
believed to be involved in a wide range of functions, including the
control of appetite, mood, anxiety, hallucinations, sleep, vomiting and
pain perception [6]. 5HT receptor ligands are of clinical use in the
treatment of depression, migraine and post-operative vomiting.
 
Numerous receptor subtypes have been classified according to their
antagonist susceptibilities and their affinities for 5HT. Five 5HT1
subtypes and at least three 5HT2 subtypes have now been identified, in
addition to subtypes 5HT3-7 [6]. All share a high degree of sequence
similarity, and have overlapping pharmacological specificities.
 
5HTRECEPTOR is a 4-element fingerprint that provides a signature for the
5HT receptors. The fingerprint was derived from an initial alignment of
31 sequences: the motifs were drawn from conserved sections within either
TM or C-terminal regions, focusing on those areas of the alignment that
characterise the 5HT receptors but distinguish them from the rest of the
rhodopsin-like superfamily - motif 1 lies in the C-terminal portion of TM
domain 1; motif 2 spans the N-terminal portion of TM domain 5; motif 3 lies
in the C-terminal portion of TM domain 6; and motif 4 resides at the
C-terminus. Three iterations on SPTR37_9f were required to reach convergence,
at which point a true set comprising 48 sequences was identified. Numerous
partial matches were also found, all of which are 5HT receptors and closely-
related members of the superfamily that fail to match one or more motifs. 
Summary Information
  48 codes involving  4 elements
6 codes involving 3 elements
38 codes involving 2 elements
Composite Feature Index
448484848
35661
230181810
1234
True Positives
5H1A_HUMAN    5H1A_MOUSE    5H1A_RAT      5H1B_CAVPO    
5H1B_CRIGR 5H1B_HUMAN 5H1B_MOUSE 5H1B_RABIT
5H1B_RAT 5H1D_CANFA 5H1D_CAVPO 5H1D_FUGRU
5H1D_HUMAN 5H1D_MOUSE 5H1D_RABIT 5H1D_RAT
5H1E_HUMAN 5H1F_CAVPO 5H1F_HUMAN 5H1F_MOUSE
5H1F_RAT 5H2A_CRIGR 5H2A_HUMAN 5H2A_MACMU
5H2A_MOUSE 5H2A_PIG 5H2A_RAT 5H2B_HUMAN
5H2B_MOUSE 5H2B_RAT 5H2C_HUMAN 5H2C_MOUSE
5H2C_RAT 5H5A_HUMAN 5H5A_MOUSE 5H5A_RAT
5H5B_MOUSE 5H5B_RAT 5H7_CAVPO 5H7_HUMAN
5H7_MOUSE 5H7_RAT 5H7_XENLA O42384
O42385 P78336 P97842 Q98998
True Positive Partials
Codes involving 3 elements
5H1B_DIDMA 5H1B_SPAEH 5HT_LYMST O18512
O76267 Q62842
Codes involving 2 elements
5HTA_DROME 5HTB_DROME 5HT_BOMMO 5HT_HELVI
A2AA_CAVPO A2AA_HUMAN A2AA_PIG A2AB_RAT
A2AC_HUMAN A2AC_MOUSE A2AC_RAT A2AD_HUMAN
A2AR_CARAU A2AR_LABOS B1AR_MELGA B3AR_BOVIN
D2D1_XENLA D2DR_BOVIN D2DR_CERAE D2DR_FUGRU
D2DR_HUMAN D2DR_MOUSE D3DR_CERAE D3DR_HUMAN
D3DR_MOUSE D3DR_RAT DOP2_DROME O15969
O73810 O77254 O77408 OAR2_LYMST
OAR_BOMMO OAR_DROME OAR_HELVI Q93126
Q93128 YDBM_CAEEL
Sequence Titles
5H1A_HUMAN  5-HYDROXYTRYPTAMINE 1A RECEPTOR (5-HT-1A) (SEROTONIN RECEPTOR) (5- HT1A) (G-21) - HOMO SAPIENS (HUMAN). 
5H1A_MOUSE 5-HYDROXYTRYPTAMINE 1A RECEPTOR (5-HT-1A) (SEROTONIN RECEPTOR) (5- HT1A) - MUS MUSCULUS (MOUSE).
5H1A_RAT 5-HYDROXYTRYPTAMINE 1A RECEPTOR (5-HT-1A) (SEROTONIN RECEPTOR) (5- HT1A) - RATTUS NORVEGICUS (RAT).
5H1B_CAVPO 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR) (5-HT1B RECEPTOR) - CAVIA PORCELLUS (GUINEA PIG).
5H1B_CRIGR 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR) - CRICETULUS GRISEUS (CHINESE HAMSTER).
5H1B_HUMAN 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR) (5-HT-1D-BETA) (S12) - HOMO SAPIENS (HUMAN).
5H1B_MOUSE 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR) - MUS MUSCULUS (MOUSE).
5H1B_RABIT 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR) (5-HT-1D-BETA) - ORYCTOLAGUS CUNICULUS (RABBIT).
5H1B_RAT 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR) - RATTUS NORVEGICUS (RAT).
5H1D_CANFA 5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTOR) - CANIS FAMILIARIS (DOG).
5H1D_CAVPO 5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTOR) - CAVIA PORCELLUS (GUINEA PIG).
5H1D_FUGRU 5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTOR) - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
5H1D_HUMAN 5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTOR) (5-HT-1D-ALPHA) - HOMO SAPIENS (HUMAN).
5H1D_MOUSE 5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTOR) - MUS MUSCULUS (MOUSE).
5H1D_RABIT 5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTOR) (5-HT-1D-ALPHA) - ORYCTOLAGUS CUNICULUS (RABBIT).
5H1D_RAT 5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTOR) - RATTUS NORVEGICUS (RAT).
5H1E_HUMAN 5-HYDROXYTRYPTAMINE 1E RECEPTOR (5-HT-1E) (SEROTONIN RECEPTOR) (5- HT1E) (S31) - HOMO SAPIENS (HUMAN).
5H1F_CAVPO 5-HYDROXYTRYPTAMINE 1F RECEPTOR (5-HT-1F) (SEROTONIN RECEPTOR) (5- HT1F) - CAVIA PORCELLUS (GUINEA PIG).
5H1F_HUMAN 5-HYDROXYTRYPTAMINE 1F RECEPTOR (5-HT-1F) (SEROTONIN RECEPTOR) - HOMO SAPIENS (HUMAN).
5H1F_MOUSE 5-HYDROXYTRYPTAMINE 1F RECEPTOR (5-HT-1F) (SEROTONIN RECEPTOR) (5-HT-1E-BETA) - MUS MUSCULUS (MOUSE).
5H1F_RAT 5-HYDROXYTRYPTAMINE 1F RECEPTOR (5-HT-1F) (SEROTONIN RECEPTOR) - RATTUS NORVEGICUS (RAT).
5H2A_CRIGR 5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTOR) (5-HT-2) - CRICETULUS GRISEUS (CHINESE HAMSTER).
5H2A_HUMAN 5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTOR) (5-HT-2) - HOMO SAPIENS (HUMAN).
5H2A_MACMU 5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTOR) (5-HT-2) - MACACA MULATTA (RHESUS MACAQUE).
5H2A_MOUSE 5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTOR) (5-HT-2) - MUS MUSCULUS (MOUSE).
5H2A_PIG 5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTOR) (5-HT-2) (5-HT2A) - SUS SCROFA (PIG).
5H2A_RAT 5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTOR) (5-HT-2) - RATTUS NORVEGICUS (RAT).
5H2B_HUMAN 5-HYDROXYTRYPTAMINE 2B RECEPTOR (5-HT-2B) (SEROTONIN RECEPTOR) - HOMO SAPIENS (HUMAN).
5H2B_MOUSE 5-HYDROXYTRYPTAMINE 2B RECEPTOR (5-HT-2B) (SEROTONIN RECEPTOR) (5-HT-2F) (NP75 PROTEIN) - MUS MUSCULUS (MOUSE).
5H2B_RAT 5-HYDROXYTRYPTAMINE 2B RECEPTOR (5-HT-2B) (SEROTONIN RECEPTOR) (5-HT-2F) (STOMACH FUNDUS SEROTONIN RECEPTOR) - RATTUS NORVEGICUS (RAT).
5H2C_HUMAN 5-HYDROXYTRYPTAMINE 2C RECEPTOR (5-HT-2C) (SEROTONIN RECEPTOR) (5HT-1C) - HOMO SAPIENS (HUMAN).
5H2C_MOUSE 5-HYDROXYTRYPTAMINE 2C RECEPTOR (5-HT-2C) (SEROTONIN RECEPTOR) (5HT-1C) - MUS MUSCULUS (MOUSE).
5H2C_RAT 5-HYDROXYTRYPTAMINE 2C RECEPTOR (5-HT-2C) (SEROTONIN RECEPTOR) (5HT-1C) - RATTUS NORVEGICUS (RAT).
5H5A_HUMAN 5-HYDROXYTRYPTAMINE 5A RECEPTOR (5-HT-5A) (SEROTONIN RECEPTOR) (5-HT-5) - HOMO SAPIENS (HUMAN).
5H5A_MOUSE 5-HYDROXYTRYPTAMINE 5A RECEPTOR (5-HT-5A) (SEROTONIN RECEPTOR) (5-HT-5) - MUS MUSCULUS (MOUSE).
5H5A_RAT 5-HYDROXYTRYPTAMINE 5A RECEPTOR (5-HT-5A) (SEROTONIN RECEPTOR) (REC17) - RATTUS NORVEGICUS (RAT).
5H5B_MOUSE 5-HYDROXYTRYPTAMINE 5B RECEPTOR (5-HT-5B) (SEROTONIN RECEPTOR) - MUS MUSCULUS (MOUSE).
5H5B_RAT 5-HYDROXYTRYPTAMINE 5B RECEPTOR (5-HT-5B) (SEROTONIN RECEPTOR) (MR22) - RATTUS NORVEGICUS (RAT).
5H7_CAVPO 5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (5-HT-X) (SEROTONIN RECEPTOR) - CAVIA PORCELLUS (GUINEA PIG).
5H7_HUMAN 5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (5-HT-X) (SEROTONIN RECEPTOR) (5HT7) - HOMO SAPIENS (HUMAN).
5H7_MOUSE 5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (5-HT-X) (SEROTONIN RECEPTOR) (5HT7) - MUS MUSCULUS (MOUSE).
5H7_RAT 5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (5-HT-X) (SEROTONIN RECEPTOR) (5HT7) (GPRFO) - RATTUS NORVEGICUS (RAT).
5H7_XENLA 5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (SEROTONIN RECEPTOR) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O42384 SEROTONIN RECEPTOR - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
O42385 SEROTONIN RECEPTOR - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
P78336 5-HYDROXYTRYPTAMINE7 RECEPTOR ISOFORM D - HOMO SAPIENS (HUMAN).
P97842 5-HYDROXYTRYPTAMINE7 RECEPTOR ISOFORM C - RATTUS NORVEGICUS (RAT).
Q98998 5-HT1A RECEPTOR - XENOPUS LAEVIS (AFRICAN CLAWED FROG).

5H1B_DIDMA 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR) - DIDELPHIS MARSUPIALIS VIRGINIANA (NORTH AMERICAN OPOSSUM).
5H1B_SPAEH 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR) - SPALAX LEUCODON EHRENBERGI (EHRENBERG'S MOLE RAT).
5HT_LYMST 5-HYDROXYTRYPTAMINE RECEPTOR (5-HT RECEPTOR) (SEROTONIN RECEPTOR) - LYMNAEA STAGNALIS (GREAT POND SNAIL).
O18512 SEROTONIN RECEPTOR PRECURSOR - CAENORHABDITIS ELEGANS.
O76267 G-PROTEIN-COUPLED 5-HYDROXYTRYPTAMINE RECEPTOR - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE).
Q62842 SEROTONIN 5-HT2C - RATTUS NORVEGICUS (RAT).

5HTA_DROME 5-HYDROXYTRYPTAMINE RECEPTOR 2A (5-HT RECEPTOR) (SEROTONIN RECEPTOR) - DROSOPHILA MELANOGASTER (FRUIT FLY).
5HTB_DROME 5-HYDROXYTRYPTAMINE RECEPTOR 2B (5-HT RECEPTOR) (SEROTONIN RECEPTOR) - DROSOPHILA MELANOGASTER (FRUIT FLY).
5HT_BOMMO 5-HYDROXYTRYPTAMINE RECEPTOR (5-HT RECEPTOR) (SEROTONIN RECEPTOR) - BOMBYX MORI (SILK MOTH).
5HT_HELVI 5-HYDROXYTRYPTAMINE RECEPTOR (5-HT RECEPTOR) (SEROTONIN RECEPTOR) - HELIOTHIS VIRESCENS (NOCTUID MOTH) (OWLET MOTH).
A2AA_CAVPO ALPHA-2A ADRENERGIC RECEPTOR (ALPHA-2A ADRENOCEPTOR) (ALPHA-2AAR) - CAVIA PORCELLUS (GUINEA PIG).
A2AA_HUMAN ALPHA-2A ADRENERGIC RECEPTOR (ALPHA-2A ADRENOCEPTOR) (ALPHA-2AAR SUBTYPE C10) - HOMO SAPIENS (HUMAN).
A2AA_PIG ALPHA-2A ADRENERGIC RECEPTOR (ALPHA-2A ADRENOCEPTOR) (ALPHA-2AAR) - SUS SCROFA (PIG).
A2AB_RAT ALPHA-2B ADRENERGIC RECEPTOR (ALPHA-2B ADRENOCEPTOR) - RATTUS NORVEGICUS (RAT).
A2AC_HUMAN ALPHA-2C-1 ADRENERGIC RECEPTOR (ALPHA-2C-1 ADRENOCEPTOR) (SUBTYPE C4) - HOMO SAPIENS (HUMAN).
A2AC_MOUSE ALPHA-2C ADRENERGIC RECEPTOR (ALPHA-2C ADRENOCEPTOR) (SUBTYPE C4) - MUS MUSCULUS (MOUSE).
A2AC_RAT ALPHA-2C ADRENERGIC RECEPTOR (ALPHA-2C ADRENOCEPTOR) (SUBTYPE C4) - RATTUS NORVEGICUS (RAT).
A2AD_HUMAN ALPHA-2C-2 ADRENERGIC RECEPTOR (ALPHA-2C-2 ADRENOCEPTOR) - HOMO SAPIENS (HUMAN).
A2AR_CARAU ALPHA-2 ADRENERGIC RECEPTOR (ALPHA-2 ADRENOCEPTOR) - CARASSIUS AURATUS (GOLDFISH).
A2AR_LABOS ALPHA-2 ADRENERGIC RECEPTOR (ALPHA-2 ADRENOCEPTOR) - LABRUS OSSIFAGUS (CUCKOO WRASSE).
B1AR_MELGA BETA-1 ADRENERGIC RECEPTOR (BETA-T) - MELEAGRIS GALLOPAVO (COMMON TURKEY).
B3AR_BOVIN BETA-3 ADRENERGIC RECEPTOR - BOS TAURUS (BOVINE).
D2D1_XENLA D(2) DOPAMINE RECEPTOR 1 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
D2DR_BOVIN D(2) DOPAMINE RECEPTOR - BOS TAURUS (BOVINE).
D2DR_CERAE D(2) DOPAMINE RECEPTOR - CERCOPITHECUS AETHIOPS (GREEN MONKEY) (GRIVET).
D2DR_FUGRU D(2)-LIKE DOPAMINE RECEPTOR - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TAKIFUGU RUBRIPES).
D2DR_HUMAN D(2) DOPAMINE RECEPTOR - HOMO SAPIENS (HUMAN).
D2DR_MOUSE D(2) DOPAMINE RECEPTOR - MUS MUSCULUS (MOUSE), AND RATTUS NORVEGICUS (RAT).
D3DR_CERAE D(3) DOPAMINE RECEPTOR - CERCOPITHECUS AETHIOPS (GREEN MONKEY) (GRIVET).
D3DR_HUMAN D(3) DOPAMINE RECEPTOR - HOMO SAPIENS (HUMAN).
D3DR_MOUSE D(3) DOPAMINE RECEPTOR - MUS MUSCULUS (MOUSE).
D3DR_RAT D(3) DOPAMINE RECEPTOR - RATTUS NORVEGICUS (RAT).
DOP2_DROME DOPAMINE RECEPTOR 2 - DROSOPHILA MELANOGASTER (FRUIT FLY).
O15969 SEROTONIN RECEPTOR-LIKE PLANARIAN RECEPTOR 4 - DUGESIA JAPONICA (PLANARIAN).
O73810 D2 DOPAMINE RECEPTOR - MELEAGRIS GALLOPAVO (COMMON TURKEY).
O77254 G-PROTEIN COUPLED RECEPTOR - BOOPHILUS MICROPLUS (CATTLE TICK).
O77408 OCTOPAMINE RECEPTOR 1 (OA1) - LYMNAEA STAGNALIS (GREAT POND SNAIL).
OAR2_LYMST Octopamine receptor 2 (OA2) - Lymnaea stagnalis (Great pond snail).
OAR_BOMMO Octopamine receptor - Bombyx mori (Silk moth).
OAR_DROME Tyramine/octopamine receptor precursor (Tyr/Oct-Dro) - Drosophila melanogaster (Fruit fly).
OAR_HELVI Octopamine receptor - Heliothis virescens (Noctuid moth) (Owlet moth).
Q93126 G PROTEIN-COUPLED RECEPTOR - BALANUS AMPHITRITE.
Q93128 G PROTEIN-COUPLED RECEPTOR - BALANUS AMPHITRITE.
YDBM_CAEEL PROBABLE G PROTEIN-COUPLED RECEPTOR F01E11.5 - CAENORHABDITIS ELEGANS.
Scan History
SPTR37_9f  3  607  NSINGLE    
Initial Motifs
Motif 1  width=9
Element Seqn Id St Int Rpt
VVISVCFVK 5H7_RAT 105 105 -
VVISVCFVK 5H7_MOUSE 105 105 -
VVISVCFVK 5H7_HUMAN 102 102 -
VLTTILLTK 5H1D_RAT 56 56 -
VLTTILLTR 5H1D_RABIT 59 59 -
VVAAIALER 5H1A_HUMAN 57 57 -
VVAAIALER 5H1A_RAT 57 57 -
VITAIIVTR 5H1F_RAT 44 44 -
VIAAIIVTR 5H1F_MOUSE 44 44 -
VLTTILLTR 5H1D_HUMAN 59 59 -
VIAAIIVTR 5H1F_HUMAN 44 44 -
VIATVYRTR 5H1B_HUMAN 70 70 -
VIATVYRTR 5H1B_MOUSE 66 66 -
VIATVYRTR 5H1B_CRIGR 66 66 -
VLTTIFLTR 5H1D_CANFA 59 59 -
VIMAVSLEK 5H2A_CRIGR 95 95 -
VIMAVSLEK 5H2A_RAT 95 95 -
VIMAVSLEK 5H2A_MOUSE 95 95 -
VLATILRVR 5H5A_RAT 61 61 -
VLATILRVR 5H5A_HUMAN 61 61 -
VLATILKVR 5H5A_MOUSE 61 61 -
VLVTILRVR 5H5B_RAT 73 73 -
VIMAVSLEK 5H2A_HUMAN 95 95 -
VLVTILRVR 5H5B_MOUSE 73 73 -
VIMAVSMEK 5H2C_MOUSE 75 75 -
VIMAVSMEK 5H2C_RAT 75 75 -
VIMAVSMEK 5H2C_HUMAN 74 74 -
VILAVALEK 5H2B_MOUSE 74 74 -
VILAVSLEK 5H2B_HUMAN 75 75 -
VILAVSLEK 5H2B_RAT 74 74 -
VVISVCFVK 5H7_CAVPO 103 103 -

Motif 2 width=9
Element Seqn Id St Int Rpt
VLIGSFVAF 5H2A_RAT 235 131 -
TIYSTCGAF 5H1D_RAT 195 130 -
TIYSTCGAF 5H1D_RABIT 198 130 -
TIYSTFGAF 5H1A_HUMAN 196 130 -
TIYSTFGAF 5H1A_RAT 196 130 -
TIYSTFGAF 5H1F_RAT 182 129 -
TIYSTFGAF 5H1F_MOUSE 182 129 -
TIYSTCGAF 5H1D_HUMAN 198 130 -
TIYSTFGAF 5H1F_HUMAN 182 129 -
TVYSTVGAF 5H1B_HUMAN 209 130 -
TVYSTVGAF 5H1B_MOUSE 205 130 -
TVYSTGGAF 5H1B_CRIGR 205 130 -
TIYSTCGAF 5H1D_CANFA 198 130 -
VLIGSFVAF 5H2A_CRIGR 235 131 -
VLIGSFVAF 5H2A_MOUSE 235 131 -
TVFSTVGAF 5H5A_RAT 201 131 -
AVFSTVGAF 5H5A_HUMAN 201 131 -
TVFSTVGAF 5H5A_MOUSE 201 131 -
AVFSTCGAF 5H5B_RAT 214 132 -
VLIGSFVSF 5H2A_HUMAN 235 131 -
AVFSTCGAF 5H5B_MOUSE 214 132 -
VLIGSFVAF 5H2C_MOUSE 216 132 -
VLIGSFVAF 5H2C_RAT 216 132 -
VLIGSFVAF 5H2C_HUMAN 215 132 -
MVFGSLAAF 5H2B_MOUSE 217 134 -
MLFGSLAAF 5H2B_HUMAN 218 134 -
MLFGSLAAF 5H2B_RAT 217 134 -
TIYSTAVAF 5H7_CAVPO 241 129 -
TIYSTAVAF 5H7_RAT 243 129 -
TIYSTAVAF 5H7_HUMAN 240 129 -
TIYSTAVAF 5H7_MOUSE 243 129 -

Motif 3 width=12
Element Seqn Id St Int Rpt
FFVASLVLPICR 5H1D_CANFA 317 110 -
FFVVSLVLPICR 5H1D_RAT 314 110 -
FFVASLVLPICR 5H1D_RABIT 317 110 -
FFIVALVLPFCE 5H1A_HUMAN 361 156 -
FFIVALVLPFCE 5H1A_RAT 361 156 -
FFVKELVVNICE 5H1F_RAT 309 118 -
FFVKELVVNVCE 5H1F_MOUSE 309 118 -
FFVVSLVLPICR 5H1D_HUMAN 317 110 -
FFVKELVVNVCD 5H1F_HUMAN 309 118 -
FFIISLVMPICK 5H1B_HUMAN 330 112 -
FFIISLVMPICK 5H1B_MOUSE 326 112 -
FFIISLVMPICK 5H1B_CRIGR 326 112 -
FFITNIMAVICK 5H2A_CRIGR 339 95 -
FFITNIMAVICK 5H2A_RAT 339 95 -
FFITNIMAVICK 5H2A_MOUSE 339 95 -
FFVTELISPLCS 5H5A_RAT 301 91 -
FFLTELISPLCS 5H5A_HUMAN 301 91 -
FFVTELISPLCS 5H5A_MOUSE 301 91 -
FFLTELVSPLCA 5H5B_RAT 314 91 -
FFITNIMAVICK 5H2A_HUMAN 339 95 -
FFLTELISPLCA 5H5B_MOUSE 314 91 -
FFITNILSVLCG 5H2C_MOUSE 328 103 -
FFITNILSVLCG 5H2C_RAT 329 104 -
FFITNILSVLCE 5H2C_HUMAN 327 103 -
FFITNLTLALCD 5H2B_MOUSE 339 113 -
FFITNITLVLCD 5H2B_HUMAN 340 113 -
FFITNVTLALCD 5H2B_RAT 339 113 -
FLLSTARPFICG 5H7_CAVPO 345 95 -
FLLSTARPFICG 5H7_RAT 347 95 -
FLLSTARPFICG 5H7_HUMAN 344 95 -
FLLSTARPFICG 5H7_MOUSE 347 95 -

Motif 4 width=6
Element Seqn Id St Int Rpt
TLFNKT 5H2B_HUMAN 381 29 -
AFFNRD 5H7_HUMAN 385 29 -
SFFNRD 5H7_MOUSE 388 29 -
AYFNKD 5H1A_RAT 401 28 -
AYFNKD 5H1A_HUMAN 401 28 -
TLFNKT 5H2B_RAT 380 29 -
AFFNRD 5H7_CAVPO 386 29 -
TVFNED 5H1D_RAT 354 28 -
TIFNED 5H1F_RAT 348 27 -
TIFNED 5H1F_MOUSE 348 27 -
TVFNEE 5H1D_HUMAN 357 28 -
TIFNED 5H1F_HUMAN 348 27 -
TMSNED 5H1B_HUMAN 370 28 -
TMSNED 5H1B_MOUSE 366 28 -
AFFNRD 5H7_RAT 388 29 -
TMSNED 5H1B_CRIGR 366 28 -
TVFNEE 5H1D_CANFA 357 28 -
TLFNKT 5H2A_CRIGR 381 30 -
TLFNKT 5H2A_RAT 381 30 -
TVFNED 5H1D_RABIT 357 28 -
TLFNKT 5H2A_MOUSE 381 30 -
TAFNRS 5H5A_RAT 339 26 -
TAFNKN 5H5A_HUMAN 339 26 -
TAFNRS 5H5A_MOUSE 339 26 -
TAFNKN 5H5B_RAT 352 26 -
TLFNKT 5H2A_HUMAN 381 30 -
TAFNKN 5H5B_MOUSE 352 26 -
TLFNKI 5H2C_MOUSE 370 30 -
TLFNKI 5H2C_RAT 371 30 -
TLFNKI 5H2C_HUMAN 369 30 -
TLFNKT 5H2B_MOUSE 380 29 -
Final Motifs
Motif 1  width=9
Element Seqn Id St Int Rpt
VVISVCFVK P78336 102 102 -
VVISVCFVK 5H7_MOUSE 105 105 -
VVISVCFVK 5H7_HUMAN 102 102 -
VVISVCFVK 5H7_RAT 105 105 -
VIAAIALER Q98998 51 51 -
VLTTILLTR 5H1D_CAVPO 59 59 -
VLTTILLTK 5H1D_MOUSE 56 56 -
VLTTILLTK 5H1D_RAT 56 56 -
VLTTILLTR 5H1D_RABIT 59 59 -
VVAAIALER 5H1A_HUMAN 57 57 -
VVAAIALER 5H1A_RAT 57 57 -
VVAAIALER 5H1A_MOUSE 57 57 -
VVAAIALER O42385 66 66 -
VVAAIALER O42384 54 54 -
VITAIIVTR 5H1F_RAT 44 44 -
VIAAIIVTR 5H1F_CAVPO 44 44 -
VIAAIIVTR 5H1F_MOUSE 44 44 -
VLTTILLTR 5H1D_HUMAN 59 59 -
VIAAIIVTR 5H1F_HUMAN 44 44 -
VIATVYRTR 5H1B_HUMAN 70 70 -
VIATVYRTR 5H1B_RAT 66 66 -
VIATVYRTR 5H1B_MOUSE 66 66 -
VIATVYRTR 5H1B_CAVPO 69 69 -
VIATVYRTR 5H1B_CRIGR 66 66 -
VLTTIFLTR 5H1D_CANFA 59 59 -
VVATVYRTR 5H1B_RABIT 70 70 -
VIATIFLTR 5H1D_FUGRU 57 57 -
VIMAVSLEK 5H2A_CRIGR 95 95 -
VIMAVSLEK 5H2A_RAT 95 95 -
VIMAVSLEK 5H2A_MOUSE 95 95 -
VIMAIGTTK 5H1E_HUMAN 43 43 -
VLATILRVR 5H5A_RAT 61 61 -
VLATILRVR 5H5A_HUMAN 61 61 -
VLATILKVR 5H5A_MOUSE 61 61 -
VLVTILRVR 5H5B_RAT 73 73 -
VIMAVSLEK 5H2A_HUMAN 95 95 -
VIMAVSLEK 5H2A_PIG 95 95 -
VIMAVSLEK 5H2A_MACMU 95 95 -
VLVTILRVR 5H5B_MOUSE 73 73 -
VIMAVSMEK 5H2C_MOUSE 75 75 -
VIMAVSMEK 5H2C_RAT 75 75 -
VIMAVSMEK 5H2C_HUMAN 74 74 -
VILAVALEK 5H2B_MOUSE 74 74 -
VILAVSLEK 5H2B_HUMAN 75 75 -
VILAVSLEK 5H2B_RAT 74 74 -
VIISVCIVK 5H7_XENLA 91 91 -
VVISVCFVK 5H7_CAVPO 103 103 -
VVISVCFVK P97842 105 105 -

Motif 2 width=9
Element Seqn Id St Int Rpt
TIYSTCGAF 5H1D_CANFA 198 130 -
TIYSTFGAF Q98998 190 130 -
TIYSTCGAF 5H1D_CAVPO 198 130 -
TIYSTCGAF 5H1D_MOUSE 195 130 -
TIYSTCGAF 5H1D_RAT 195 130 -
TIYSTCGAF 5H1D_RABIT 198 130 -
TIYSTFGAF 5H1A_HUMAN 196 130 -
TIYSTFGAF 5H1A_RAT 196 130 -
TIYSTFGAF 5H1A_MOUSE 196 130 -
TIYSTFGAF O42385 205 130 -
TIYSTFGAF O42384 198 135 -
TIYSTFGAF 5H1F_RAT 182 129 -
TIYSTFGAF 5H1F_CAVPO 182 129 -
TIYSTFGAF 5H1F_MOUSE 182 129 -
TIYSTCGAF 5H1D_HUMAN 198 130 -
TIYSTFGAF 5H1F_HUMAN 182 129 -
TVYSTVGAF 5H1B_HUMAN 209 130 -
TVYSTVGAF 5H1B_RAT 205 130 -
TVYSTVGAF 5H1B_MOUSE 205 130 -
TVYSTGGAF 5H1B_CAVPO 208 130 -
TVYSTGGAF 5H1B_CRIGR 205 130 -
TVYSTVGAF 5H1B_RABIT 209 130 -
TLYSTFGAF 5H1D_FUGRU 196 130 -
VLIGSFVAF 5H2A_CRIGR 235 131 -
VLIGSFVAF 5H2A_RAT 235 131 -
VLIGSFVAF 5H2A_MOUSE 235 131 -
TIYSTLGAF 5H1E_HUMAN 183 131 -
TVFSTVGAF 5H5A_RAT 201 131 -
AVFSTVGAF 5H5A_HUMAN 201 131 -
TVFSTVGAF 5H5A_MOUSE 201 131 -
AVFSTCGAF 5H5B_RAT 214 132 -
VLIGSFVSF 5H2A_HUMAN 235 131 -
VLIGSFVSF 5H2A_PIG 235 131 -
VLIGSFVSF 5H2A_MACMU 235 131 -
AVFSTCGAF 5H5B_MOUSE 214 132 -
VLIGSFVAF 5H2C_MOUSE 216 132 -
VLIGSFVAF 5H2C_RAT 216 132 -
VLIGSFVAF 5H2C_HUMAN 215 132 -
MVFGSLAAF 5H2B_MOUSE 217 134 -
MLFGSLAAF 5H2B_HUMAN 218 134 -
MLFGSLAAF 5H2B_RAT 217 134 -
TVYSTAVAF 5H7_XENLA 229 129 -
TIYSTAVAF 5H7_CAVPO 241 129 -
TIYSTAVAF P97842 243 129 -
TIYSTAVAF P78336 240 129 -
TIYSTAVAF 5H7_RAT 243 129 -
TIYSTAVAF 5H7_HUMAN 240 129 -
TIYSTAVAF 5H7_MOUSE 243 129 -

Motif 3 width=12
Element Seqn Id St Int Rpt
FFVASLVLPICR 5H1D_CANFA 317 110 -
FFIVALVLPFCE Q98998 348 149 -
FFVVSLVLPICR 5H1D_CAVPO 316 109 -
FFVVSLVLPICR 5H1D_MOUSE 314 110 -
FFVVSLVLPICR 5H1D_RAT 314 110 -
FFVASLVLPICR 5H1D_RABIT 317 110 -
FFIVALVLPFCE 5H1A_HUMAN 361 156 -
FFIVALVLPFCE 5H1A_RAT 361 156 -
FFIVALVLPFCE 5H1A_MOUSE 361 156 -
FFIVALVLPFCA O42385 362 148 -
FFIVALVMPFCQ O42384 355 148 -
FFVKELVVNICE 5H1F_RAT 309 118 -
FFVKELVVNVCE 5H1F_CAVPO 309 118 -
FFVKELVVNVCE 5H1F_MOUSE 309 118 -
FFVVSLVLPICR 5H1D_HUMAN 317 110 -
FFVKELVVNVCD 5H1F_HUMAN 309 118 -
FFIISLVMPICK 5H1B_HUMAN 330 112 -
FFIISLVMPICK 5H1B_RAT 326 112 -
FFIISLVMPICK 5H1B_MOUSE 326 112 -
FFIISLVMPICK 5H1B_CAVPO 329 112 -
FFIISLVMPICK 5H1B_CRIGR 326 112 -
FFIISLVMPICK 5H1B_RABIT 330 112 -
FFVVTLVWAICK 5H1D_FUGRU 322 117 -
FFITNIMAVICK 5H2A_CRIGR 339 95 -
FFITNIMAVICK 5H2A_RAT 339 95 -
FFITNIMAVICK 5H2A_MOUSE 339 95 -
FFIKELIVGLSI 5H1E_HUMAN 307 115 -
FFVTELISPLCS 5H5A_RAT 301 91 -
FFLTELISPLCS 5H5A_HUMAN 301 91 -
FFVTELISPLCS 5H5A_MOUSE 301 91 -
FFLTELVSPLCA 5H5B_RAT 314 91 -
FFITNIMAVICK 5H2A_HUMAN 339 95 -
FFITNIMAVICK 5H2A_PIG 338 94 -
FFITNIMAVICK 5H2A_MACMU 339 95 -
FFLTELISPLCA 5H5B_MOUSE 314 91 -
FFITNILSVLCG 5H2C_MOUSE 328 103 -
FFITNILSVLCG 5H2C_RAT 329 104 -
FFITNILSVLCE 5H2C_HUMAN 327 103 -
FFITNLTLALCD 5H2B_MOUSE 339 113 -
FFITNITLVLCD 5H2B_HUMAN 340 113 -
FFITNVTLALCD 5H2B_RAT 339 113 -
FLLSTARPFICG 5H7_XENLA 340 102 -
FLLSTARPFICG 5H7_CAVPO 345 95 -
FLLSTARPFICG P97842 347 95 -
FLLSTARPFICG P78336 344 95 -
FLLSTARPFICG 5H7_RAT 347 95 -
FLLSTARPFICG 5H7_HUMAN 344 95 -
FLLSTARPFICG 5H7_MOUSE 347 95 -

Motif 4 width=6
Element Seqn Id St Int Rpt
TLFNKT 5H2B_RAT 380 29 -
AFFNRD 5H7_RAT 388 29 -
AFFNRD 5H7_HUMAN 385 29 -
SFFNRD 5H7_MOUSE 388 29 -
AYFNKD 5H1A_MOUSE 401 28 -
AYFNKD 5H1A_RAT 401 28 -
AYFNKD 5H1A_HUMAN 401 28 -
AFFNRD 5H7_XENLA 381 29 -
AFFNRD 5H7_CAVPO 386 29 -
AFFNRD P97842 388 29 -
AYFNKD Q98998 387 27 -
TVFNED 5H1D_CAVPO 356 28 -
TVFNED 5H1D_MOUSE 354 28 -
TVFNED 5H1D_RAT 354 28 -
AYFNKD O42385 402 28 -
AYFNKD O42384 395 28 -
TIFNED 5H1F_RAT 348 27 -
TIFNED 5H1F_CAVPO 348 27 -
TIFNED 5H1F_MOUSE 348 27 -
TVFNEE 5H1D_HUMAN 357 28 -
TIFNED 5H1F_HUMAN 348 27 -
TMSNED 5H1B_HUMAN 370 28 -
TMSNED 5H1B_RAT 366 28 -
TMSNED 5H1B_MOUSE 366 28 -
AFFNRD P78336 385 29 -
TMSNED 5H1B_CAVPO 369 28 -
TMSNED 5H1B_CRIGR 366 28 -
TVFNEE 5H1D_CANFA 357 28 -
TVFNED 5H1D_RABIT 357 28 -
TMSNED 5H1B_RABIT 370 28 -
TVFNDE 5H1D_FUGRU 361 27 -
TLFNKT 5H2A_CRIGR 381 30 -
TLFNKT 5H2A_RAT 381 30 -
TLFNKT 5H2A_MOUSE 381 30 -
TSFNED 5H1E_HUMAN 345 26 -
TAFNRS 5H5A_RAT 339 26 -
TAFNKN 5H5A_HUMAN 339 26 -
TAFNRS 5H5A_MOUSE 339 26 -
TAFNKN 5H5B_RAT 352 26 -
TLFNKT 5H2A_HUMAN 381 30 -
TLFNKT 5H2A_PIG 380 30 -
TLFNKT 5H2A_MACMU 381 30 -
TAFNKN 5H5B_MOUSE 352 26 -
TLFNKI 5H2C_MOUSE 370 30 -
TLFNKI 5H2C_RAT 371 30 -
TLFNKI 5H2C_HUMAN 369 30 -
TLFNKT 5H2B_MOUSE 380 29 -
TLFNKT 5H2B_HUMAN 381 29 -