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PR01095

Identifier
TASKCHANNEL  [View Relations]  [View Alignment]  
Accession
PR01095
No. of Motifs
3
Creation Date
11-FEB-1999  (UPDATE 08-MAY-2008)
Title
TASK K+ channel signature
Database References
PRINTS; PR00169 KCHANNEL; PR01333 2POREKCHANEL; PR01584 TASK1CHANNEL
PRINTS; PR01585 TASK3CHANNEL; PR01690 TASK5CHANNEL
PFAM; PF07885 Ion_trans_2
INTERPRO; IPR003092; IPR003280; IPR005406; IPR005407; IPR008073; IPR013099

MIM; 603220; 603493; 605874; 607368
Literature References
1. KETCHUM, K.A., JOINER, W.J., SELLERS, A.J., KACZMAREK, L.K. AND
GOLDSTEIN, S.A.N.
A new family of outwardly rectifying potassium channel proteins with two
pore domains in tandem.
NATURE 376 690-695 (1995).
 
2. GOLDSTEIN, S.A.N., PRICE, L.A., ROSENTHAL, D.N. AND PAUSCH, M.H.
ORK1, a potassium-selective leak channel with two pore domains cloned from
Drosophila melanogaster by expression in Saccharomyces cerevisiae.
PROC.NATL.ACAD.SCI.U.S.A. 93 13256-13261 (1996).
 
3. FINK, M. DUPRAT, F., LESAGE, F., REYES, R., ROMEY, G., HEURTEAUX, C. AND
LAZDUNSKI, M.
Cloning, functional expression and brain localization of a novel
unconventional outward rectifier K+ channel.
EMBO J. 15 6854-6862 (1996).
 
4. LESAGE, F., GUILLEMARE, E., FINK, M., DUPRAT, F., LAZDUNSKI, M., ROMEY,
G. AND BARHANIN, J.
TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with novel
structure.
EMBO J. 15 1004-1011 (1996).
 
5. DUPRAT, F., LESAGE, F., FINK, M., REYES, R., HEURTEAUX, C. AND
LAZDUNSKI, M.
TASK, a human background K+ channel to sense external pH variations near
physiological pH.
EMBO J. 16 5464-5471 (1997).
 
6. FINK, M., LESAGE, F., DUPRAT, F., HEURTEAUX, C., REYES, R., FOSSET, M.
AND LAZDUNSKI, M.
A neuronal two P domain K+ channel stimulated by arachidonic acid and
polyunsaturated fatty acids.
EMBO J. 17 3297-3308 (1998).
 
7. PATEL, A.J. AND HONORE, E.
Properties and modulation of mammalian 2P-domain K+ channels.
TRENDS NEUROSCI. 24(6) 339-346 (2001).

Documentation
Potassium (K+) channels play a key role in many cellular functions, in both
excitable and non-excitable tissues. Among the ion channels, they form the
largest family in terms of both structure and function. K+ channel subunits
contain a conserved pore-forming motif, the P-domain, which is considered to
be an essential element of the aqueous K+-selective pore. Shaker-type and
Kir K+ channel subunits both contain a single P-domain, and four such
subunits are thought to associate to form a multimer, together with 
associated auxillary (regulatory) subunits. Recently, a new class of K+ 
channel subunits was cloned, which is clearly distinct from the Shaker and
Kir families; the new class contains not one but two P-domains in each 
subunit, and evidence suggests a complete channel may be formed by the 
dimerisation of two such subunits.
 
The first member of this family (TOK1) cloned from S.cerevisiae [1] was
predicted to have eight potential transmembrane (TM) helices. However,
subsequently-cloned two P-domain family members from Drosophila and
mammalian species are predicted to have only four TM segments. They are
usually referred to as TWIK-related channels (Tandem of P-domains in a 
Weakly Inward rectifying K+ channel) [2-6]. Functional characterisation of
these channels has revealed a diversity of properties in that they may show 
inward or outward rectification, their activity may be modulated in 
different directions by protein phosphorylation, and their sensitivity to
changes in intracellular or extracellular pH varies. Despite these disparate
properties, they are all thought to share the same topology of four TM 
segments, including two P-domains. That TWIK-related K+ channels all produce
instantaneous and non-inactivating K+ currents, which do not display a
voltage-dependent activation threshold, suggests that they are background 
(leak) K+ channels involved in the generation and modulation of the resting
membrane potential in various cell types. Further studies have revealed that
they may be found in many species, including: plants, invertebrates and 
mammals.
 
The TASK (TWIK-related acid-sensitive K+ channel) family contains five
members (TASK1-5), which share no more than 54% amino acid identity. These
form functional K+ channels in various cell types and encode background
K+ channels, thereby helping to set the resting membrane potential. All
members are very sensitive to variations in extracellular pH in the
physiological range, changing from fully-open to closed in approximately
0.5pH units around pH7.4. Thus, they may well constitute biological sensors
of external pH variations [7].
 
TASKCHANNEL is a 3-element fingerprint that provides a signature for the
TASK K+ channel. The fingerprint was derived from an initial alignment of 5
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length, focusing on those sections that characterise
TASK channel proteins but distinguish them from related two P-domain K+
channel sequences - motif 1 is situated in the N-terminus; motif 2 spans 
the second putative TM domain; and motif 3 is located in the fourth TM
domain. Three iterations on SPTR39.22_17.3f were required to reach 
convergence, at which point a true set comprising 16 sequences was
identified. Several partial matches were also found, all of which are
members of the TASK family.
 
An update on SPTR55_38f identified a true set comprising 41 sequences, 
together with 4 partial matches.
Summary Information
  41 codes involving  3 elements
4 codes involving 2 elements
Composite Feature Index
3414141
2224
123
True Positives
A2AHD2_MOUSE  A5WW77_DANRE  A6YQS3_LYMST  A8KB52_DANRE  
A8X4U9_CAEBR A8XVW8_CAEBR CIW9_CAVPO CIW9_HUMAN
KCNK9_MOUSE KCNK9_RAT KCNK9_XENLA KCNKF_RAT
O14649 O17185 O35111 O54912
O76790 O95279 Q058Y1_DROME Q16NN0_AEDAE
Q172H0_AEDAE Q2KTA6_RAT Q32PR9_DANRE Q3T9D4_MOUSE
Q3ZZY0_DROME Q3ZZY1_DROME Q4RQY2_TETNG Q4SDP6_TETNG
Q52LL3_HUMAN Q53SU2_HUMAN Q5HZL7_XENLA Q5RGB0_DANRE
Q5TZ59_DANRE Q5UE95_RABIT Q5VV76_HUMAN Q6PFU3_DANRE
Q7QC61_ANOGA Q9H427 Q9JK62 Q9VFS9
Q9VHE0
True Positive Partials
Codes involving 2 elements
KCNKG_HUMAN Q6X6Z5_HUMAN Q9ESM4 Q9ESM5
Sequence Titles
A2AHD2_MOUSE Potassium channel, subfamily K, member 15 - Mus musculus (Mouse). 
A5WW77_DANRE Novel protein similar to vertebrate potassium channel, subfamily K, member 9 (KCNK9) - Danio rerio (Zebrafish) (Brachydanio rerio).
A6YQS3_LYMST TASK two-pore domain potassium channel - Lymnaea stagnalis (Great pond snail).
A8KB52_DANRE Putative uncharacterized protein - Danio rerio (Zebrafish) (Brachydanio rerio).
A8X4U9_CAEBR Putative uncharacterized protein - Caenorhabditis briggsae.
A8XVW8_CAEBR Putative uncharacterized protein - Caenorhabditis briggsae.
CIW9_CAVPO POTASSIUM CHANNEL SUBFAMILY K MEMBER 9 (ACID-SENSITIVE POTASSIUM CHANNEL PROTEIN TASK-3) (TWIK-RELATED ACID-SENSITIVE K+ CHANNEL 3) - Cavia porcellus (Guinea pig).
CIW9_HUMAN POTASSIUM CHANNEL SUBFAMILY K MEMBER 9 (ACID-SENSITIVE POTASSIUM CHANNEL PROTEIN TASK-3) (TWIK-RELATED ACID-SENSITIVE K+ CHANNEL 3) - Homo sapiens (Human).
KCNK9_MOUSE Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3) - Mus musculus (Mouse).
KCNK9_RAT Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3) (Two pore potassium channel KT3.2) - Rattus norvegicus (Rat).
KCNK9_XENLA Potassium channel subfamily K member 9 - Xenopus laevis (African clawed frog).
KCNKF_RAT Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (rTASK-5) - Rattus norvegicus (Rat).
O14649 TWIK-RELATED ACID-SENSITIVE K+ CHANNEL - HOMO SAPIENS (HUMAN).
O17185 F34D6.3 PROTEIN - Caenorhabditis elegans.
O35111 CTBAK - MUS MUSCULUS (MOUSE).
O54912 TWIK-RELATED ACID-SENSITIVE K+ CHANNEL - RATTUS NORVEGICUS (RAT).
O76790 PUTATIVE POTASSIUM CHANNEL SUBUNIT N2P20 - Caenorhabditis elegans.
O95279 TWO PORE DOMAIN K+ CHANNEL - HOMO SAPIENS (HUMAN).
Q058Y1_DROME IP11279p - Drosophila melanogaster (Fruit fly).
Q16NN0_AEDAE Putative uncharacterized protein - Aedes aegypti (Yellowfever mosquito).
Q172H0_AEDAE Putative uncharacterized protein - Aedes aegypti (Yellowfever mosquito).
Q2KTA6_RAT Potassium channel, subfamily K, member 5 (Similar to potassium channel TASK2) - Rattus norvegicus (Rat).
Q32PR9_DANRE Zgc:123271 - Danio rerio (Zebrafish) (Brachydanio rerio).
Q3T9D4_MOUSE Activated spleen cDNA, RIKEN full-length enriched library, clone:F830219D13 product:potassium channel, subfamily K, member 5, full insert sequence - Mus musculus (Mouse).
Q3ZZY0_DROME Acid-sensitive two pore domain K+ channel dTASK-7 - Drosophila melanogaster (Fruit fly).
Q3ZZY1_DROME Acid-sensitive two pore domain K+ channel dTASK-6 - Drosophila melanogaster (Fruit fly).
Q4RQY2_TETNG Chromosome 14 SCAF15003, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer).
Q4SDP6_TETNG Chromosome 10 SCAF14634, whole genome shotgun sequence - Tetraodon nigroviridis (Green puffer).
Q52LL3_HUMAN Potassium channel, subfamily K, member 15 - Homo sapiens (Human).
Q53SU2_HUMAN Putative uncharacterized protein KCNK3 (Potassium channel, subfamily K, member 3, isoform CRA_a) - Homo sapiens (Human).
Q5HZL7_XENLA LOC496362 protein - Xenopus laevis (African clawed frog).
Q5RGB0_DANRE Novel protein (Zgc:63921) - Danio rerio (Zebrafish) (Brachydanio rerio).
Q5TZ59_DANRE Novel protein similar to vertebrate potassium channel, subfamily K, member 3 (KCNK3) - Danio rerio (Zebrafish) (Brachydanio rerio).
Q5UE95_RABIT Potassium channel, subfamily K, member 5 - Oryctolagus cuniculus (Rabbit).
Q5VV76_HUMAN Potassium channel, subfamily K, member 5 (Potassium channel, subfamily K, member 5, isoform CRA_a) - Homo sapiens (Human).
Q6PFU3_DANRE Potassium channel, subfamily K, member 5 - Danio rerio (Zebrafish) (Brachydanio rerio).
Q7QC61_ANOGA AGAP002466-PA - Anopheles gambiae str. PEST.
Q9H427 DJ781B1.1 (A NOVEL PROTEIN SIMILAR TO THE ACID-SENSITIVE POTASSIUM CHANNEL PROTEIN TASK (KCNK3)) - Homo sapiens (Human).
Q9JK62 POTASSIUM CHANNEL TASK2 (TASK2 POTASSIUM CHANNEL) - Mus musculus (Mouse).
Q9VFS9 CG9637 PROTEIN - Drosophila melanogaster (Fruit fly).
Q9VHE0 CG9361 PROTEIN - Drosophila melanogaster (Fruit fly).

KCNKG_HUMAN Potassium channel subfamily K member 16 (TWIK-related alkaline pH- activated K(+) channel 1) (2P domain potassium channel Talk-1) - Homo sapiens (Human).
Q6X6Z5_HUMAN Pancreatic potassium channel TALK-1b - Homo sapiens (Human).
Q9ESM4 TWIK-RELATED ACID-SENSITIVE K+ CHANNEL SPRICE VARIANT (TASK1C) - Rattus norvegicus (Rat).
Q9ESM5 TASK1 SPLICE BVARIANT (TASK1B) - Rattus norvegicus (Rat).
Scan History
SPTR39.22_17.3f 3  100  NSINGLE    
SPTR55_38f 3 300 NSINGLE
Initial Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
LIVCTFTYLLVGAAVFDALESEP CIW3_HUMAN 11 11 -
LIVCTFTYLLVGAAVFDALESEP CIW3_RAT 11 11 -
LTSAIIFYLAIGAAIFEVLEEPH CIW5_HUMAN 8 8 -
LIACTFTYLLVGAAVFDALESDH CIW9_CAVPO 11 11 -
LVLCTLCYLLVGAAVFDALESEA Q9HBC8 11 11 -

Motif 2 width=17
Element Seqn Id St Int Rpt
LVMFQSLGERINTLVRY CIW3_HUMAN 122 88 -
LVMFQSLGERINTFVRY CIW3_RAT 122 88 -
LTWISALGKFFGGRAKR CIW5_HUMAN 127 96 -
LVMFQSLGERMNTFVRY CIW9_CAVPO 122 88 -
LVTFQSLGERLNAVVRR Q9HBC8 122 88 -

Motif 3 width=15
Element Seqn Id St Int Rpt
FSFVYILTGLTVIGA CIW3_HUMAN 223 84 -
FSFVYILTGLTVIGA CIW3_RAT 223 84 -
FVELWIYLGLAWLSL CIW5_HUMAN 226 82 -
FSFMYILVGLTVIGA CIW9_CAVPO 223 84 -
FSFLYILLGLTVIGA Q9HBC8 223 84 -
Final Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
LIVCTFTYLLVGAAVFDALESEP O35111 11 11 -
LIVCTFTYLLVGAAVFDALESEP O54912 11 11 -
LIVCTFTYLLVGAAVFDALESDH CIW9_HUMAN 11 11 -
LIACTFTYLLVGAAVFDALESDH CIW9_CAVPO 11 11 -
LIACTFTYLLVGAAVFDALESDH KCNK9_RAT 11 11 -
LIACTFTYLLVGAAVFDALESDH KCNK9_MOUSE 11 11 -
LIVCTFTYLLVGAAVFDALESDF A5WW77_DANRE 11 11 -
LIVCTFTYLLVGAAVFDALESEP O14649 11 11 -
LIVCTFTYLLVGAAVFDALESEP Q53SU2_HUMAN 11 11 -
LIICTFTYLLVGAAVFDALESDY KCNK9_XENLA 11 11 -
LIICTFTYLLVGAAVFDALESKM Q5TZ59_DANRE 11 11 -
LILCILSYLLVGAAVFDALESEA A2AHD2_MOUSE 11 11 -
LILCIFSYLLVGAAVFVALESDT A8KB52_DANRE 11 11 -
LVLCTLCYLLVGAAVFDALESEA Q9H427 11 11 -
LVLCTLCYLLVGAAVFDALESEA Q52LL3_HUMAN 11 11 -
LILCILSYLLVGAAVFDALESEA KCNKF_RAT 11 11 -
LIICTFTYLIAGAAIFDALESQT Q4RQY2_TETNG 11 11 -
LIVCTLTYLLVGAAVFDALETEN A8XVW8_CAEBR 11 11 -
LIVCTLTYLLVGAAVFDALETEN O17185 11 11 -
LIVCTFTYLLVGAAVFDALESEF A6YQS3_LYMST 11 11 -
LVVCTFTYLLIGAAVFDALESET Q172H0_AEDAE 11 11 -
LVVCTFTYLLIGAAVFDALESET Q7QC61_ANOGA 11 11 -
LVVCTFTYLLIGAAVFDSLESPT Q3ZZY0_DROME 11 11 -
LVVCTFTYLLIGAAVFDSLESPT Q9VHE0 12 12 -
LIVCTFTYLLIGAAVFDALESET Q16NN0_AEDAE 11 11 -
LIISILTYLVVGAAVFETLESKQ Q4SDP6_TETNG 11 11 -
LIVCTFTYLLVGAAVFDALESET Q058Y1_DROME 11 11 -
LIVCTFTYLLVGAAVFDALESET Q3ZZY1_DROME 11 11 -
LILSTFTYLLFGAMIFDKLESED A8X4U9_CAEBR 14 14 -
LILSTFTYLLFGAMVFDKLESEK O76790 14 14 -
LIVCTFTYLLVGAAVFDALESET Q9VFS9 11 11 -
LTSAIIFYLAIGAAIFEVLEEPH O95279 8 8 -
LTSAIIFYLAIGAAIFEVLEEPH Q9JK62 8 8 -
LTSAIIFYLAIGAAIFEVLEEPH Q5VV76_HUMAN 8 8 -
LTSAIIFYLAIGAAIFEVLEEPH Q5UE95_RABIT 8 8 -
LTSAIIFYLAIGAAIFEVLEEPH Q3T9D4_MOUSE 8 8 -
LTSAIIFYLAIGAAIFEVLEEPH Q2KTA6_RAT 8 8 -
LTSAVIFYLSIGAAIFQVLEEPN Q5HZL7_XENLA 8 8 -
LTSVIIFYLSIGAAIFQILEEPN Q5RGB0_DANRE 8 8 -
LTSVIIFYLSIGAAIFQILEEPN Q6PFU3_DANRE 8 8 -
LTSAIIFYLSIGAAIFQVIEEPN Q32PR9_DANRE 8 8 -

Motif 2 width=17
Element Seqn Id St Int Rpt
LVMFQSLGERINTFVRY O35111 122 88 -
LVMFQSLGERINTFVRY O54912 122 88 -
LVMFQSLGERMNTFVRY CIW9_HUMAN 122 88 -
LVMFQSLGERMNTFVRY CIW9_CAVPO 122 88 -
LVMFQSLGERMNTFVRY KCNK9_RAT 122 88 -
LVMFQSLGERMNTFVRY KCNK9_MOUSE 122 88 -
LVMFQSLGERMNTFVKY A5WW77_DANRE 122 88 -
LVMFQSLGERINTLVRY O14649 122 88 -
LVMFQSLGERINTLVRY Q53SU2_HUMAN 122 88 -
LVMFQSLGERMNTFVKY KCNK9_XENLA 122 88 -
LVMFQSLGERINTFVKY Q5TZ59_DANRE 122 88 -
LVTFQSLGERLNTLVRC A2AHD2_MOUSE 122 88 -
LVMFQSLGERMNTGVRF A8KB52_DANRE 122 88 -
LVTFQSLGERLNAVVRR Q9H427 122 88 -
LVTFQSLGERLNAVVRR Q52LL3_HUMAN 122 88 -
LVTFQSLGERLNALVRC KCNKF_RAT 122 88 -
LVMFQSVGERINTCVRY Q4RQY2_TETNG 208 174 -
LIMFQSIGERMNTFAAK A8XVW8_CAEBR 122 88 -
LIMFQSIGERMNTFAAK O17185 122 88 -
IVMFQSVGERLNTFVTF A6YQS3_LYMST 122 88 -
LVMFQSIGERLNKFASV Q172H0_AEDAE 122 88 -
LVMFQSIGERLNKFASV Q7QC61_ANOGA 122 88 -
LVMFQSIGERLNKFASV Q3ZZY0_DROME 122 88 -
LVMFQSIGERLNKFASV Q9VHE0 123 88 -
LVMFQSIGERVNRLSSV Q16NN0_AEDAE 122 88 -
LVMFQSLGERINTFVRY Q4SDP6_TETNG 122 88 -
LVMFQSIGERVNRLSSY Q058Y1_DROME 122 88 -
LVMFQSIGERVNRLSSY Q3ZZY1_DROME 122 88 -
LVMFQSIGERVNTFIAY A8X4U9_CAEBR 125 88 -
LIMFQSIGERVNTFIAY O76790 125 88 -
LVMFQSIGERAVRSSLR Q9VFS9 122 88 -
LTWISALGKFFGGRAKR O95279 127 96 -
LTWISALGKFFGGRAKR Q9JK62 127 96 -
LTWISALGKFFGGRAKR Q5VV76_HUMAN 127 96 -
LTWISALGKFFGGRAKR Q5UE95_RABIT 127 96 -
LTWISALGKFFGGRAKR Q3T9D4_MOUSE 127 96 -
LTWISALGKFFGGRAKR Q2KTA6_RAT 127 96 -
LTWISALGKFFGGRAKR Q5HZL7_XENLA 127 96 -
LTWISELGTFFGSRTKR Q5RGB0_DANRE 127 96 -
LTWISELGTFFGSRTKR Q6PFU3_DANRE 127 96 -
FTWISELGKFFGGRAKH Q32PR9_DANRE 127 96 -

Motif 3 width=15
Element Seqn Id St Int Rpt
FSFVYILTGLTVIGA O35111 223 84 -
FSFVYILTGLTVIGA O54912 223 84 -
FSFMYILVGLTVIGA CIW9_HUMAN 223 84 -
FSFMYILVGLTVIGA CIW9_CAVPO 223 84 -
FSFMYILVGLTVIGA KCNK9_RAT 223 84 -
FSFMYILVGLTVIGA KCNK9_MOUSE 223 84 -
FSFMYILVGLTVIGA A5WW77_DANRE 223 84 -
FSFVYILTGLTVIGA O14649 223 84 -
FSFVYILTGLTVIGA Q53SU2_HUMAN 223 84 -
FSFMYILVGLTVIGA KCNK9_XENLA 223 84 -
FSFMYILTGLTVIGA Q5TZ59_DANRE 223 84 -
FSFLYILLGLTVIGA A2AHD2_MOUSE 223 84 -
FSFIYILLGLTVIGA A8KB52_DANRE 223 84 -
FSFLYILLGLTVIGA Q9H427 223 84 -
FSFLYILLGLTVIGA Q52LL3_HUMAN 223 84 -
FSFLYILLGLTVIGA KCNKF_RAT 223 84 -
FSFIYILTGLAVIGA Q4RQY2_TETNG 309 84 -
FSLVFILFGLTVISA A8XVW8_CAEBR 222 83 -
FSLVFILFGLTVISA O17185 222 83 -
FCLIFILFGLTVISA A6YQS3_LYMST 223 84 -
LSLVFILFGLAVVAA Q172H0_AEDAE 223 84 -
LSLVFILFGLAVVAA Q7QC61_ANOGA 223 84 -
LSLVFILFGLAVVAA Q3ZZY0_DROME 223 84 -
LSLVFILFGLAVVAA Q9VHE0 224 84 -
FALIFILFGLAVVAA Q16NN0_AEDAE 223 84 -
FCFVYILMGLTTLCS Q4SDP6_TETNG 223 84 -
FALIFILFGLAIVAA Q058Y1_DROME 223 84 -
FALIFILFGLAIVAA Q3ZZY1_DROME 223 84 -
ATILFILVGLAVFSA A8X4U9_CAEBR 230 88 -
ATIMFILIGLAVFSA O76790 230 88 -
FALIFILFGLAIVAA Q9VFS9 213 74 -
FVELWIYLGLAWLSL O95279 226 82 -
FVELWIYLGLAWLSL Q9JK62 226 82 -
FVELWIYLGLAWLSL Q5VV76_HUMAN 226 82 -
FVELWIYLGLAWLSL Q5UE95_RABIT 226 82 -
FVELWIYLGLAWLSL Q3T9D4_MOUSE 226 82 -
FVELWIYLGLAWLSL Q2KTA6_RAT 226 82 -
FVEIWIYLGLAWLSL Q5HZL7_XENLA 226 82 -
FVQLWIYLGLAWLSL Q5RGB0_DANRE 226 82 -
FVQLWIYLGLAWLSL Q6PFU3_DANRE 226 82 -
FVEVWIYLGLAWLSL Q32PR9_DANRE 226 82 -