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PR01079

Identifier
GABAARALPHA  [View Relations]  [View Alignment]  
Accession
PR01079
No. of Motifs
8
Creation Date
25-JAN-1999  (UPDATE 10-JUN-1999)
Title
Gamma-aminobutyric-acid A receptor alpha subunit signature
Database References
PRINTS; PR00252 NRIONCHANNEL; PR00253 GABAARECEPTR; PR01614 GABAARALPHA1
PRINTS; PR01615 GABAARALPHA2; PR01616 GABAARALPHA3; PR01617 GABAARALPHA4
PRINTS; PR01618 GABAARALPHA5; PR01619 GABAARALPHA6
INTERPRO; IPR001390
Literature References
1. KOFUJI, P., WANG, J.B., MOSS, S.J., HUGANIR, R.L. AND BURT, D.R.
Generation of two forms of the gamma-aminobutyric acid A receptor gamma
2-subunit in mice by alternative splicing.
J.NEUROCHEM. 56 713-715 (1991).
 
2. WANG, J.B., KOFUJI, P., FERNANDO, J.C., MOSS, S.J., HUGANIR, R.L.
AND BURT, D.R.
The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison
in seizure-prone and -resistant mice and during development.
J.MOL.NEUROSCIENCE 3 177-184 (1992).
 
3. LEVITAN, E.S., SCHOFIELD, P.R., BURT, D.R., RHEE, L.M., WISDEN, W.,
KOHLER, M., FUJITA, N., RODRIGUEZ, H.F., STEPHENSON, A., DARLISON, M.G., 
BARNARD, E.A. AND SEEBURG, P.H.
Structural and functional basis for GABAA receptor heterogeneity.
NATURE 335 76-79 (1988).
 
4. KHRESTCHATISKY, M., MACLENNAN, A.J., TILLAKARATNE, N.J., CHIANG, M.Y.
AND TOBIN, A.J.
Sequence and regional distribution of the mRNA encoding the alpha 2
polypeptide of rat gamma-aminobutyric acid A receptors.
J.NEUROCHEM. 56 1717-1722 (1991).
 
5. THOMPSON, M., SHOTKOSKI, F. AND FFRENCH-CONSTANT, R.
Cloning and sequencing of the cyclodiene insecticide resistance gene from
the yellow fever mosquito Aedes aegypti. Conservation of the gene and 
resistance associated mutation with Drosophila.
FEBS LETT. 325(3) 187-90 (1993). 
 
6. SIGEL, E., BAUR, R., KELLENBERGER, S. AND MALHERBE, P.
Point mutations affecting antagonist affinity and agonist dependent gating 
of GABAA receptor channels.
EMBO J. 11 2017-2023 (1992). 

Documentation
Gamma-aminobutyric acid (GABA) receptors are members of the neurotransmitter
ligand-gated ion channels: they mediate neuronal inhibition by opening 
chloride channels on binding GABA [1,2]. There are 5 classes of receptor
subunit (alpha, beta, gamma, delta and rho), with variants in each class
[3]. Each subunit contains 4 proposed transmembrane (TM) domains, with a
large intracellular loop between the third and fourth domain. Active
receptors contain 5 subunits of varying classes and variants - the use
of highly similar receptor subtypes, which differ in functionality, is a
common feature of brain receptors [3].
 
The neurotransmitter action of the subtype A receptor (GABAA) is
potentiated by both benzodiazepines and barbiturates [3]. Alpha subunits
largely determine benzodiazepine binding properties [4], and gamma-2
subunits appear to be essential for benzodiazepine modulation of receptor
function [1]. In insects, cyclodiene (an insecticide) resistence is due to
insensitivity of the cyclodiene/picrotoxinin binding site on the GABAA
receptor-chloride ionophore complex [5].
 
Mutagenesis and agonist/antagonist binding studies have suggested a close
functional and structural association of alpha-subunits with the agonist/
antagonist binding site, and involvement of N-terminal portions of the 
extracellular domains of all subunits in the gating of the channel [6].
 
GABAARALPHA is an 8-element fingerprint that provides a signature for GABAA
alpha subunit precursors. The fingerprint was derived from an initial 
alignment of 12 sequences: the motifs were drawn from short conserved
regions spanning virtually the full alignment length, focusing on those
sections that characterise the alpha subunits but distinguish them from 
the rest of the GABA receptor superfamily - motifs 1-5 lie withing the
N-terminal extracellular domain; motif 6 spans part of the extracellular
loop and the N-terminus of putative TM domain 3; and motifs 7 and 8 span
the cytoplasmic loop and putative TM domain 4. Two iterations on OWL31.1 
were required to reach convergence, at which point a true set comprising 24
sequences was identified. Several partial matches were also found: HSGABAA
and MMAJ2970 and fragments that lack portions of sequence bearing the
C-terminal motifs; and GAC3_HUMAN, GAC3_MOUSE and GAC3_RAT are GABA
receptor gamma subunit precursors.
 
An update on SPTR37_9f identified a true set of 22 sequences, and 3
partial matches.
Summary Information
  22 codes involving  8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
3 codes involving 2 elements
Composite Feature Index
82222222222222222
700000000
600000000
500000000
400000000
300000000
200003300
12345678
True Positives
GAA1_BOVIN    GAA1_CHICK    GAA1_HUMAN    GAA1_MOUSE    
GAA2_BOVIN GAA2_HUMAN GAA2_MOUSE GAA2_RAT
GAA3_BOVIN GAA3_HUMAN GAA3_MOUSE GAA3_RAT
GAA4_BOVIN GAA4_HUMAN GAA4_RAT GAA5_HUMAN
GAA5_RAT GAA6_CHICK GAA6_HUMAN GAA6_MOUSE
GAA6_RAT Q90288
True Positive Partials
Codes involving 2 elements
GAC3_HUMAN GAC3_MOUSE GAC3_RAT
Sequence Titles
GAA1_BOVIN  Gamma-aminobutyric-acid receptor alpha-1 subunit precursor (GABA(A) receptor) - Bos taurus (Bovine). 
GAA1_CHICK Gamma-aminobutyric-acid receptor alpha-1 subunit precursor (GABA(A) receptor) - Gallus gallus (Chicken).
GAA1_HUMAN Gamma-aminobutyric-acid receptor alpha-1 subunit precursor (GABA(A) receptor) - Homo sapiens (Human).
GAA1_MOUSE Gamma-aminobutyric-acid receptor alpha-1 subunit precursor (GABA(A) receptor) - Mus musculus (Mouse), and Rattus norvegicus (Rat).
GAA2_BOVIN Gamma-aminobutyric-acid receptor alpha-2 subunit precursor (GABA(A) receptor) - Bos taurus (Bovine).
GAA2_HUMAN Gamma-aminobutyric-acid receptor alpha-2 subunit precursor (GABA(A) receptor) - Homo sapiens (Human).
GAA2_MOUSE Gamma-aminobutyric-acid receptor alpha-2 subunit precursor (GABA(A) receptor) - Mus musculus (Mouse).
GAA2_RAT Gamma-aminobutyric-acid receptor alpha-2 subunit precursor (GABA(A) receptor) - Rattus norvegicus (Rat).
GAA3_BOVIN Gamma-aminobutyric-acid receptor alpha-3 subunit precursor (GABA(A) receptor) - Bos taurus (Bovine).
GAA3_HUMAN Gamma-aminobutyric-acid receptor alpha-3 subunit precursor (GABA(A) receptor) - Homo sapiens (Human).
GAA3_MOUSE Gamma-aminobutyric-acid receptor alpha-3 subunit precursor (GABA(A) receptor) - Mus musculus (Mouse).
GAA3_RAT Gamma-aminobutyric-acid receptor alpha-3 subunit precursor (GABA(A) receptor) - Rattus norvegicus (Rat).
GAA4_BOVIN Gamma-aminobutyric-acid receptor alpha-4 subunit precursor (GABA(A) receptor) - Bos taurus (Bovine).
GAA4_HUMAN Gamma-aminobutyric-acid receptor alpha-4 subunit precursor (GABA(A) receptor) - Homo sapiens (Human).
GAA4_RAT Gamma-aminobutyric-acid receptor alpha-4 subunit precursor (GABA(A) receptor) - Rattus norvegicus (Rat).
GAA5_HUMAN Gamma-aminobutyric-acid receptor alpha-5 subunit precurso (GABA(A) receptor) - Homo sapiens (Human).
GAA5_RAT Gamma-aminobutyric-acid receptor alpha-5 subunit precurso (GABA(A) receptor) - Rattus norvegicus (Rat).
GAA6_CHICK Gamma-aminobutyric-acid receptor alpha-6 subunit precursor (GABA(A) receptor) - Gallus gallus (Chicken).
GAA6_HUMAN Gamma-aminobutyric-acid receptor alpha-6 subunit precursor (GABA(A) receptor) - Homo sapiens (Human).
GAA6_MOUSE Gamma-aminobutyric-acid receptor alpha-6 subunit precursor (GABA(A) receptor) - Mus musculus (Mouse).
GAA6_RAT Gamma-aminobutyric-acid receptor alpha-6 subunit precursor (GABA(A) receptor) - Rattus norvegicus (Rat).
Q90288 NEUROTRANSMITTER RECEPTOR ALPHA SUBUNIT PRECURSOR - CARASSIUS AURATUS (GOLDFISH).

GAC3_HUMAN Gamma-aminobutyric-acid receptor gamma-3 subunit precursor (GABA(A) receptor) - Homo sapiens (Human).
GAC3_MOUSE Gamma-aminobutyric-acid receptor gamma-3 subunit precursor (GABA(A) receptor) - Mus musculus (Mouse).
GAC3_RAT Gamma-aminobutyric-acid receptor gamma-3 subunit precursor (GABA(A) receptor) - Rattus norvegicus (Rat).
Scan History
OWL31_1    2  100  NSINGLE    
SPTR37_9f 2 34 NSINGLE
Initial Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
TVFTRILDRLLD GAA1_BOVIN 40 40 -
TVFTRILDRLLD GAA1_HUMAN 40 40 -
TIFTRILDRLLD GAA2_HUMAN 40 40 -
TIFTRILDRLLD GAA2_MOUSE 40 40 -
TIFTRILDRLLD GAA3_HUMAN 65 65 -
TIFTRILDRLLD GAA3_BOVIN 65 65 -
TIFTRILDGLLD GAA5_HUMAN 47 47 -
TIFTRILDGLLD GAA5_RAT 47 47 -
ENFTRILDSLLD GAA4_BOVIN 46 46 -
ENFTRILDSLLD GAA4_HUMAN 46 46 -
ENVSRILDNLLE GAA6_MOUSE 30 30 -
ENVSRILDNLLE GAA6_RAT 30 30 -

Motif 2 width=18
Element Seqn Id St Int Rpt
GLGERVTEVKTDIFVTSF GAA1_BOVIN 60 8 -
GLGERVTEVKTDIFVTSF GAA1_HUMAN 60 8 -
GLGDSITEVFTNIYVTSF GAA2_HUMAN 60 8 -
GLGDSITEVFTNIYVTSF GAA2_MOUSE 60 8 -
GLGDAVTEVKTDIYVTSF GAA3_HUMAN 85 8 -
GLGDAVTEVKTDIYVTSF GAA3_BOVIN 85 8 -
GLGERITQVRTDIYVTSF GAA5_HUMAN 67 8 -
GLGERITQVRTDIYVTSF GAA5_RAT 67 8 -
GFGGPVTEVKTDIYVTSF GAA4_BOVIN 66 8 -
GFGGPVTEVKTDIYVTSF GAA4_HUMAN 66 8 -
GFGGAVTEVKTDIYVTSF GAA6_MOUSE 50 8 -
GFGGAVTEVKTDIYVTSF GAA6_RAT 50 8 -

Motif 3 width=13
Element Seqn Id St Int Rpt
FKGPMTVLRLNNL GAA1_BOVIN 104 26 -
FKGPMTVLRLNNL GAA1_HUMAN 104 26 -
FKGPMNILRLNNL GAA2_HUMAN 104 26 -
FKGPMNILRLNNL GAA2_MOUSE 104 26 -
FDGPMKILPLNNL GAA3_HUMAN 129 26 -
FDGPMKILPLNNL GAA3_BOVIN 129 26 -
FKGPMQRLPLNNL GAA5_HUMAN 111 26 -
FKGPMQRLPLNNL GAA5_RAT 111 26 -
YDGPIEILRLNNM GAA4_BOVIN 110 26 -
YDGPIEILRLNNM GAA4_HUMAN 110 26 -
FKGPAEILSLNNL GAA6_MOUSE 84 16 -
FKGPAEILSLNNL GAA6_RAT 94 26 -

Motif 4 width=13
Element Seqn Id St Int Rpt
YEWTREPARSVVV GAA1_BOVIN 196 79 -
YEWTREPARSVVV GAA1_HUMAN 196 79 -
YIWTYNASDSVQV GAA2_HUMAN 196 79 -
YIWTYNASDSVQV GAA2_MOUSE 196 79 -
YSWTLGKNKSVEV GAA3_HUMAN 221 79 -
YSWTLGKNKSVEV GAA3_BOVIN 221 79 -
YVWTNGSTKSVVV GAA5_HUMAN 203 79 -
YVWTNGSTKSVVV GAA5_RAT 203 79 -
YTWTKGPEKSVEV GAA4_BOVIN 202 79 -
YTWTKGPEKSVEV GAA4_HUMAN 202 79 -
YTWKKGPLYSVEV GAA6_MOUSE 176 79 -
YTWKKGPLYSVEV GAA6_RAT 186 79 -

Motif 5 width=23
Element Seqn Id St Int Rpt
SRLNQYDLLGQTVDSGIVQSSTG GAA1_BOVIN 213 4 -
SRLNQYDLLGQTVDSGIVQSSTG GAA1_HUMAN 213 4 -
SRLNQYDLLGQSIGKETIKSSTG GAA2_HUMAN 213 4 -
SRLNQYDLLGQSIGKETIKSSTG GAA2_MOUSE 213 4 -
SRLNQYDLLGHVVGTEIIRSSTG GAA3_HUMAN 238 4 -
SRLNQYDLLGHVVGTEIIRSSTG GAA3_BOVIN 238 4 -
SRLNQYHLMGQTVGTENISTSTG GAA5_HUMAN 220 4 -
SRLNQYHLMGQTVGTENISTSTG GAA5_RAT 220 4 -
SSLVQYDLIGQTVSSETIKSITG GAA4_BOVIN 219 4 -
SSLVQYDLIGQTVSSETIKSITG GAA4_HUMAN 219 4 -
SSLLQYDLIGQTVSSETIKSNTG GAA6_MOUSE 193 4 -
SSLLQYDLIGQTVSSETIKSNTG GAA6_RAT 203 4 -

Motif 6 width=14
Element Seqn Id St Int Rpt
KVAYATAMDWFIAV GAA1_BOVIN 306 70 -
KVAYATAMDWFIAV GAA1_HUMAN 306 70 -
KVAYATAMDWFIAV GAA2_HUMAN 306 70 -
KVAYATAMDWFIAV GAA2_MOUSE 306 70 -
KVAYATAMDWFIAV GAA3_HUMAN 331 70 -
KVAYATAMDWFMAV GAA3_BOVIN 331 70 -
KVAYATAMDWFIAV GAA5_HUMAN 313 70 -
KVAYATAMDWFIAV GAA5_RAT 313 70 -
KVSYATAMDWFIAV GAA4_BOVIN 313 71 -
KVSYLTAMDWFIAV GAA4_HUMAN 312 70 -
KVSYATAMDWFIAV GAA6_MOUSE 286 70 -
KVSYATAMDWFIAV GAA6_RAT 296 70 -

Motif 7 width=13
Element Seqn Id St Int Rpt
TFNSVSKIDRLSR GAA1_BOVIN 412 92 -
TFNSVSKIDRLSR GAA1_HUMAN 412 92 -
TFNSVSKIDRMSR GAA2_HUMAN 410 90 -
TFNSVSKIDRMSR GAA2_MOUSE 410 90 -
TYNSVSKVDKISR GAA3_HUMAN 448 103 -
TYNSVSKVDKISR GAA3_BOVIN 448 103 -
TYNSISKIDKMSR GAA5_HUMAN 418 91 -
TYNSISKIDKMSR GAA5_RAT 420 93 -
SGSGTSKIDKYAR GAA4_BOVIN 513 186 -
SGSGTSKIDKYAR GAA4_HUMAN 511 185 -
ATGGTSKIDQYSR GAA6_MOUSE 400 100 -
AIGGTSKIDQYSR GAA6_RAT 410 100 -

Motif 8 width=12
Element Seqn Id St Int Rpt
VYWATYLNREPQ GAA1_BOVIN 437 12 -
VYWATYLNREPQ GAA1_HUMAN 437 12 -
VYWATYLNREPV GAA2_HUMAN 435 12 -
VYWATYLNREPV GAA2_MOUSE 435 12 -
VYWATYVNRESA GAA3_HUMAN 473 12 -
VYWATYVNRESA GAA3_BOVIN 473 12 -
VYWATYLNREPV GAA5_HUMAN 443 12 -
VYWATYLNREPV GAA5_RAT 445 12 -
VYWVVYLSKDTM GAA4_BOVIN 538 12 -
VYWVVYLSKDTM GAA4_HUMAN 536 12 -
VYWIVYLSKDTM GAA6_MOUSE 425 12 -
VYWIVYLSKDTM GAA6_RAT 435 12 -
Final Motifs
Motif 1  width=12
Element Seqn Id St Int Rpt
TVFTRILDRLLD GAA1_BOVIN 40 40 -
TVFTRILDRLLD GAA1_CHICK 40 40 -
TVFTRILDRLLD GAA1_HUMAN 40 40 -
TVFTRILDRLLD GAA1_MOUSE 39 39 -
TIFTRILDRLLD GAA2_HUMAN 40 40 -
TIFTRILDRLLD GAA2_MOUSE 40 40 -
TIFTRILDRLLD GAA2_RAT 40 40 -
TIFTRILDRLLD GAA2_BOVIN 40 40 -
TIFTRILDRLLD GAA3_HUMAN 65 65 -
TIFTRILDRLLD GAA3_MOUSE 65 65 -
TIFTRILDRLLD GAA3_BOVIN 65 65 -
TIFTRILDRLLD GAA3_RAT 65 65 -
TIFTRILDGLLD GAA5_HUMAN 47 47 -
TIFTRILDGLLD GAA5_RAT 47 47 -
ENFTRILDSLLD GAA4_BOVIN 46 46 -
ENFTRILDSLLD GAA4_RAT 46 46 -
ENITRILDKLLD GAA6_CHICK 30 30 -
ENFTRILDSLLD GAA4_HUMAN 46 46 -
ENVSRILDNLLE GAA6_HUMAN 30 30 -
ENVSRILDNLLE GAA6_MOUSE 30 30 -
ENVSRILDNLLE GAA6_RAT 30 30 -
DNITRILDRLLD Q90288 29 29 -

Motif 2 width=18
Element Seqn Id St Int Rpt
GLGERVTEVKTDIFVTSF GAA1_BOVIN 60 8 -
GLGERVTEVKTDIFVTSF GAA1_CHICK 60 8 -
GLGERVTEVKTDIFVTSF GAA1_HUMAN 60 8 -
GLGERVTEVKTDIFVTSF GAA1_MOUSE 59 8 -
GLGDSITEVFTNIYVTSF GAA2_HUMAN 60 8 -
GLGDSITEVFTNIYVTSF GAA2_MOUSE 60 8 -
GLGDSITEVFTNIYVTSF GAA2_RAT 60 8 -
GLGDSITEVFTNIYVTSF GAA2_BOVIN 60 8 -
GLGDAVTEVKTDIYVTSF GAA3_HUMAN 85 8 -
GLGDAVTEVKTDIYVTSF GAA3_MOUSE 85 8 -
GLGDAVTEVKTDIYVTSF GAA3_BOVIN 85 8 -
GLGDAVTEVKTDIYVTSF GAA3_RAT 85 8 -
GLGERITQVRTDIYVTSF GAA5_HUMAN 67 8 -
GLGERITQVRTDIYVTSF GAA5_RAT 67 8 -
GFGGPVTEVKTDIYVTSF GAA4_BOVIN 66 8 -
GFGGPVTEVKTDIYVTSF GAA4_RAT 66 8 -
GFGGAVTEVKTDIYVTSF GAA6_CHICK 50 8 -
GFGGPVTEVKTDIYVTSF GAA4_HUMAN 66 8 -
GFGGAVTEVKTDIYVTSF GAA6_HUMAN 50 8 -
GFGGAVTEVKTDIYVTSF GAA6_MOUSE 50 8 -
GFGGAVTEVKTDIYVTSF GAA6_RAT 50 8 -
GFGGPVTEVKTDIFVTSF Q90288 49 8 -

Motif 3 width=13
Element Seqn Id St Int Rpt
FKGPMTVLRLNNL GAA1_BOVIN 104 26 -
FKGPMTVLRLNNL GAA1_CHICK 104 26 -
FKGPMTVLRLNNL GAA1_HUMAN 104 26 -
FKGPMTVLRLNNL GAA1_MOUSE 103 26 -
FKGPMNILRLNNL GAA2_HUMAN 104 26 -
FKGPMNILRLNNL GAA2_MOUSE 104 26 -
FKGPMNILRLNNS GAA2_RAT 104 26 -
FKGPMNILRLNNL GAA2_BOVIN 104 26 -
FDGPMKILPLNNL GAA3_HUMAN 129 26 -
FDGPMKILPLNNL GAA3_MOUSE 129 26 -
FDGPMKILPLNNL GAA3_BOVIN 129 26 -
FDGPMKILPLNNL GAA3_RAT 129 26 -
FKGPMQRLPLNNL GAA5_HUMAN 111 26 -
FKGPMQRLPLNNL GAA5_RAT 111 26 -
YDGPIEILRLNNM GAA4_BOVIN 110 26 -
YDGPIEILRLNNM GAA4_RAT 110 26 -
FGGPTEILRLNNL GAA6_CHICK 94 26 -
YDGPIEILRLNNM GAA4_HUMAN 110 26 -
FGGPTEILSLNNL GAA6_HUMAN 94 26 -
FKGPAEILSLNNL GAA6_MOUSE 84 16 -
FKGPAEILSLNNL GAA6_RAT 94 26 -
FEGPIEILRLNNL Q90288 93 26 -

Motif 4 width=13
Element Seqn Id St Int Rpt
YEWTREPARSVVV GAA1_BOVIN 196 79 -
YEWTREPARSVVV GAA1_CHICK 196 79 -
YEWTREPARSVVV GAA1_HUMAN 196 79 -
YEWTREPARSVVV GAA1_MOUSE 195 79 -
YIWTYNASDSVQV GAA2_HUMAN 196 79 -
YIWTYNASDSVQV GAA2_MOUSE 196 79 -
YIWTYNPSDSVQV GAA2_RAT 196 79 -
YIWTYNASDSVQV GAA2_BOVIN 196 79 -
YSWTLGKNKSVEV GAA3_HUMAN 221 79 -
YSWTLGKNKSVEV GAA3_MOUSE 221 79 -
YSWTLGKNKSVEV GAA3_BOVIN 221 79 -
YSWTLGKNKSVEV GAA3_RAT 221 79 -
YVWTNGSTKSVVV GAA5_HUMAN 203 79 -
YVWTNGSTKSVVV GAA5_RAT 203 79 -
YTWTKGPEKSVEV GAA4_BOVIN 202 79 -
YTWTKGPEKSVEV GAA4_RAT 202 79 -
YTWKKGPLHSVEV GAA6_CHICK 186 79 -
YTWTKGPEKSVEV GAA4_HUMAN 202 79 -
YTWKKGPLYSVEV GAA6_HUMAN 186 79 -
YTWKKGPLYSVEV GAA6_MOUSE 176 79 -
YTWKKGPLYSVEV GAA6_RAT 186 79 -
YTWKKGPLFSVEV Q90288 185 79 -

Motif 5 width=23
Element Seqn Id St Int Rpt
SRLNQYDLLGQTVDSGIVQSSTG GAA1_BOVIN 213 4 -
SRLNQYDLLGQTVDSGIVQSSTG GAA1_CHICK 213 4 -
SRLNQYDLLGQTVDSGIVQSSTG GAA1_HUMAN 213 4 -
SRLNQYDLLGQTVDSGIVQSSTG GAA1_MOUSE 212 4 -
SRLNQYDLLGQSIGKETIKSSTG GAA2_HUMAN 213 4 -
SRLNQYDLLGQSIGKETIKSSTG GAA2_MOUSE 213 4 -
SRLNQYDLLGQSIGKETIKSSTG GAA2_RAT 213 4 -
SRLNQYDLPGQSIGKETIKSSTG GAA2_BOVIN 213 4 -
SRLNQYDLLGHVVGTEIIRSSTG GAA3_HUMAN 238 4 -
SRLNQYDLLGHVVGTEIIRSSTG GAA3_MOUSE 238 4 -
SRLNQYDLLGHVVGTEIIRSSTG GAA3_BOVIN 238 4 -
SRLNQYDLLGHVVGTEIIRSSTG GAA3_RAT 238 4 -
SRLNQYHLMGQTVGTENISTSTG GAA5_HUMAN 220 4 -
SRLNQYHLMGQTVGTENISTSTG GAA5_RAT 220 4 -
SSLVQYDLIGQTVSSETIKSITG GAA4_BOVIN 219 4 -
SSLVQYDLIGQTVSSETIKSITG GAA4_RAT 219 4 -
SSLLQYDLIGQTVSSETIKSNTG GAA6_CHICK 203 4 -
SSLVQYDLIGQTVSSETIKSITG GAA4_HUMAN 219 4 -
SSLLQYDLIGQTVSSETIKSNTG GAA6_HUMAN 203 4 -
SSLLQYDLIGQTVSSETIKSNTG GAA6_MOUSE 193 4 -
SSLLQYDLIGQTVSSETIKSNTG GAA6_RAT 203 4 -
SSLLQYDLIGQTVSSERLKSNTG Q90288 202 4 -

Motif 6 width=14
Element Seqn Id St Int Rpt
KVAYATAMDWFIAV GAA1_BOVIN 306 70 -
KVAYATAMDWFIAV GAA1_CHICK 306 70 -
KVAYATAMDWFIAV GAA1_HUMAN 306 70 -
KVAYATAMDWFIAV GAA1_MOUSE 305 70 -
KVAYATAMDWFIAV GAA2_HUMAN 306 70 -
KVAYATAMDWFIAV GAA2_MOUSE 306 70 -
KVAYATAMDWFIAV GAA2_RAT 306 70 -
KVAYATAMDWFIAV GAA2_BOVIN 306 70 -
KVAYATAMDWFIAV GAA3_HUMAN 331 70 -
KVAYATAMDWFIAV GAA3_MOUSE 331 70 -
KVAYATAMDWFMAV GAA3_BOVIN 331 70 -
KVAYATAMDWFMAV GAA3_RAT 331 70 -
KVAYATAMDWFIAV GAA5_HUMAN 313 70 -
KVAYATAMDWFIAV GAA5_RAT 313 70 -
KVSYATAMDWFIAV GAA4_BOVIN 313 71 -
KVSYATAMDWFIAV GAA4_RAT 312 70 -
KVSYATAMDWFIAV GAA6_CHICK 296 70 -
KVSYLTAMDWFIAV GAA4_HUMAN 312 70 -
KVSYATAMDWFIAV GAA6_HUMAN 296 70 -
KVSYATAMDWFIAV GAA6_MOUSE 286 70 -
KVSYATAMDWFIAV GAA6_RAT 296 70 -
KVSYATAMDWFIAV Q90288 295 70 -

Motif 7 width=13
Element Seqn Id St Int Rpt
TFNSVSKIDRLSR GAA1_BOVIN 412 92 -
TFNSVSKIDRLSR GAA1_CHICK 411 91 -
TFNSVSKIDRLSR GAA1_HUMAN 412 92 -
TFNSVSKIDRLSR GAA1_MOUSE 411 92 -
TFNSVSKIDRMSR GAA2_HUMAN 410 90 -
TFNSVSKIDRMSR GAA2_MOUSE 410 90 -
TFNSVSKIDRMSR GAA2_RAT 410 90 -
TFNSVSKIDRMSR GAA2_BOVIN 410 90 -
TYNSVSKVDKISR GAA3_HUMAN 448 103 -
TYNSVSKVDKISR GAA3_MOUSE 448 103 -
TYNSVSKVDKISR GAA3_BOVIN 448 103 -
TYNSVSKVDKISR GAA3_RAT 449 104 -
TYNSISKIDKMSR GAA5_HUMAN 418 91 -
TYNSISKIDKMSR GAA5_RAT 420 93 -
SGSGTSKIDKYAR GAA4_BOVIN 513 186 -
SGSGTSKIDKYAR GAA4_RAT 509 183 -
PVGGTSKIDQYSR GAA6_CHICK 412 102 -
SGSGTSKIDKYAR GAA4_HUMAN 511 185 -
AFGGTSKIDQYSR GAA6_HUMAN 410 100 -
ATGGTSKIDQYSR GAA6_MOUSE 400 100 -
AIGGTSKIDQYSR GAA6_RAT 410 100 -
NTLTTSIIDKYSR Q90288 397 88 -

Motif 8 width=12
Element Seqn Id St Int Rpt
VYWATYLNREPQ GAA1_BOVIN 437 12 -
VYWATYLNREPQ GAA1_CHICK 436 12 -
VYWATYLNREPQ GAA1_HUMAN 437 12 -
VYWATYLNREPQ GAA1_MOUSE 436 12 -
VYWATYLNREPV GAA2_HUMAN 435 12 -
VYWATYLNREPV GAA2_MOUSE 435 12 -
VYWATYLNREPV GAA2_RAT 435 12 -
VYWATYLNREPV GAA2_BOVIN 435 12 -
VYWATYVNRESA GAA3_HUMAN 473 12 -
VYWATYVNRESA GAA3_MOUSE 473 12 -
VYWATYVNRESA GAA3_BOVIN 473 12 -
VYWATYVNRESA GAA3_RAT 474 12 -
VYWATYLNREPV GAA5_HUMAN 443 12 -
VYWATYLNREPV GAA5_RAT 445 12 -
VYWVVYLSKDTM GAA4_BOVIN 538 12 -
VYWVVYLSKDTM GAA4_RAT 534 12 -
VYWVVYLSKDTM GAA6_CHICK 437 12 -
VYWVVYLSKDTM GAA4_HUMAN 536 12 -
VYWVVYLSKDTM GAA6_HUMAN 435 12 -
VYWIVYLSKDTM GAA6_MOUSE 425 12 -
VYWIVYLSKDTM GAA6_RAT 435 12 -
VYWIVYLTKDTM Q90288 422 12 -