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PR01077

Identifier
CLAUDIN  [View Relations]  [View Alignment]  
Accession
PR01077
No. of Motifs
3
Creation Date
30-OCT-2002
Title
Claudin family signature
Database References
PRINTS; PR01377 CLAUDIN1; PR01383 CLAUDIN10; PR01384 CLAUDIN11
PRINTS; PR01872 CLAUDIN12; PR01385 CLAUDIN14; PR01718 CLAUDIN15
PRINTS; PR01447 CLAUDIN16; PR01448 CLAUDIN18; PR01589 CLAUDIN2
PRINTS; PR01378 CLAUDIN3; PR01379 CLAUDIN4; PR01380 CLAUDIN5
PRINTS; PR01445 CLAUDIN6; PR01381 CLAUDIN7; PR01446 CLAUDIN8
PRINTS; PR01382 CLAUDIN9
PROSITE; PS01346 CLAUDIN
INTERPRO; IPR006188
Literature References
1. TSUKITA, S. AND FURUSE, M.
Occludin and claudins in tight-junction strands: leading or supporting
players?
TRENDS CELL BIOL. 9 268-273 (1999).
 
2. FURUSE, M., FUJITA, K., HIIRAGI, T., FUJIMOTO, K. AND TSUKITA, S.
Claudin-1 and -2: novel integral membrane proteins localizing at tight
junctions with no sequence similarity to occludin.
J.CELL BIOL. 141 1539-1550 (1998).
 
3. FURUSE, M., SASAKI, H., FUJIMOTO, K. AND TSUKITA, S.
A single gene product, claudin-1 or -2, reconstitutes tight junction
strands and recruits occludin in fibroblasts.
J.CELL BIOL. 143 391-401 (1998).
 
4. MORITA, K., FURUSE, M., FUJIMOTO, K. AND TSUKITA, S.
Claudin multigene family encoding four-transmembrane domain protein
components of tight junction strands.
PROC.NATL.ACAD.SCI.U.S.A. 96 511-516 (1999).
 
5. HEISKALA, M., PETERSON, P.A. AND YANG, Y.
The Roles of the Claudin Superfamily Proteins in Paracellular Transport.
TRAFFIC 2 92-98 (2001).

Documentation
Tight junctions (TJs) are specialised membrane domains found at the
most apical region of polarised epithelial and endothelial cells. They
create a primary barrier, preventing paracellular transport of solutes and 
restricting lateral diffusion of membrane lipids and proteins. They also
act as diffusion barriers within plasma membranes, creating and maintaining 
apical and basolateral membrane domains.
 
Recently, the molecular architecture of tight junctions has begun to be
elucidated. One group of proteins thought to be major components of TJs is
the claudin family [1]. Immunofluorescence studies have shown that claudins
are targeted to and incorporated into tight junctions [2]. Furthermore,
when claudins are introduced into cells that lack tight junctions, networks
of strands and grooves form at cell-cell contact sites that closely
resemble native TJs [3].
 
The claudin protein family is encoded by at least 18 human genes, with
many homologues cloned from other species. Tissue distribution patterns for
the claudin family members are distinct [4]: claudin 11, for example, is
found predominantly in the CNS; and claudin 16 mRNA is expressed in the
kidney. Defects in claudin genes therefore give rise to diseases in a
tissue-specific manner: alterations in claudin 11 have been implicated in
multiple sclerosis; and mutations in the claudin 16 gene affect the
re-uptake of magnesium ions in the kidney, leading to renal failure [5].
 
The claudins are believed to share a common topology, comprising four
membrane-spanning helices (TM1 to 4) with the N- and C-termini located in
the cytoplasm. The first extracellular loop is longer and more hydrophobic
than the second, and is believed to bridge the extracellular space. Among
claudins, the greatest level of sequence conservation is observed in TM1
and 4, as well as the extracellular loops. The sequences of TM2, TM3 and,
in particular, the C-terminus display the greatest level of diversity in
primary structure. Many claudin family members feature a -Y-V motif at the
C-terminus; this sequence interacts with the PDZ domain, a module of 80-90
residues found in other tight junction-associated membrane proteins, such
as ZO-1 [4].
 
CLAUDIN is a 3-element fingerprint that provides a signature for the
claudin family. The fingerprint was derived from an initial alignment
of 62 proteins: motifs were drawn from the central portion of the alignment,
focusing on those sections that characterise the claudins but distinguish 
them from closely related proteins, such as calcium channel gamma subunits -
the motifs span the first, second and fourth putative TM domains,
respectively. Three iterations on SPTR40_20f were required to reach
convergence, at which point a true set comprising 71 sequences was obtained.
A single partial match was also found, Q8VC62, a hypothetical mouse protein 
that matches motifs 1 and 2.
Summary Information
  71 codes involving  3 elements
1 codes involving 2 elements
Composite Feature Index
3717171
2110
123
True Positives
CLD1_RAT      CLD2_HUMAN    CLD6_HUMAN    CLD6_MOUSE    
CLD8_HUMAN CLD8_MOUSE CLDD_MOUSE CLDF_HUMAN
CLDG_BOVIN CLDG_HUMAN CLDH_HUMAN CLDI_HUMAN
CLDI_MOUSE CLDJ_HUMAN CLDX_BRARE CLDY_BRARE
CLDZ_BRARE O00501 O14493 O15551
O19005 O35054 O54942 O75508
O88551 O88552 O95471 O95484
O95500 O95832 P78369 Q60771
Q63400 Q90XQ8 Q90XQ9 Q90XR0
Q90XR2 Q90XR4 Q90XR5 Q90XR6
Q90XR7 Q90XR8 Q90XR9 Q90XS0
Q90XS1 Q91X40 Q91Y55 Q91ZY9
Q91ZZ0 Q91ZZ1 Q925N4 Q96N78
Q96PH4 Q98SR1 Q98SR2 Q99P82
Q9CX57 Q9D7D7 Q9D7U6 Q9D7Z0
Q9D8A6 Q9DB65 Q9DE12 Q9N9W1
Q9N9W2 Q9TUF7 Q9Z0G9 Q9Z0S3
Q9Z0S6 Q9Z0S7 Q9Z261
True Positive Partials
Codes involving 2 elements
Q8VC62
Sequence Titles
CLD1_RAT    Claudin-1 - Rattus norvegicus (Rat).          
CLD2_HUMAN Claudin-2 - Homo sapiens (Human).
CLD6_HUMAN Claudin-6 - Homo sapiens (Human).
CLD6_MOUSE Claudin-6 - Mus musculus (Mouse).
CLD8_HUMAN Claudin-8 - Homo sapiens (Human).
CLD8_MOUSE Claudin-8 - Mus musculus (Mouse).
CLDD_MOUSE Claudin-13 - Mus musculus (Mouse).
CLDF_HUMAN Claudin-15 - Homo sapiens (Human).
CLDG_BOVIN Claudin-16 (CL-16) - Bos taurus (Bovine).
CLDG_HUMAN Claudin-16 (Paracellin-1) (PCLN-1) - Homo sapiens (Human).
CLDH_HUMAN Claudin-17 - Homo sapiens (Human).
CLDI_HUMAN Claudin-18 - Homo sapiens (Human).
CLDI_MOUSE Claudin-18 - Mus musculus (Mouse).
CLDJ_HUMAN Claudin-20 - Homo sapiens (Human).
CLDX_BRARE Claudin-like protein ZF4A22 (Clausin 7) - Brachydanio rerio (Zebrafish) (Zebra danio).
CLDY_BRARE Claudin-like protein ZF-A89 - Brachydanio rerio (Zebrafish) (Zebra danio).
CLDZ_BRARE Claudin-like protein ZF-A9 - Brachydanio rerio (Zebrafish) (Zebra danio).
O00501 TRANSMEMBRANE PROTEIN DELETED IN VCFS - HOMO SAPIENS (HUMAN).
O14493 CPE-RECEPTOR - HOMO SAPIENS (HUMAN).
O15551 RAT VENTRAL PROSTATE.1 HOMOLOG - HOMO SAPIENS (HUMAN).
O19005 CPE-RECEPTOR - CERCOPITHECUS AETHIOPS (GREEN MONKEY) (GRIVET).
O35054 CPE-RECEPTOR - MUS MUSCULUS (MOUSE).
O54942 BEC1 PROTEIN - MUS MUSCULUS (MOUSE).
O75508 OLIGODENDROCYTE-SPECIFIC PROTEIN - HOMO SAPIENS (HUMAN).
O88551 CLAUDIN-1 - MUS MUSCULUS (MOUSE).
O88552 CLAUDIN-2 - MUS MUSCULUS (MOUSE).
O95471 CLAUDIN-9 - HOMO SAPIENS (HUMAN).
O95484 CLAUDIN-6 PROTEIN - HOMO SAPIENS (HUMAN).
O95500 CLAUDIN-14 - HOMO SAPIENS (HUMAN).
O95832 SENESCENCE-ASSOCIATED EPITHELIAL MEMBRANE PROTEIN - HOMO SAPIENS (HUMAN).
P78369 PUTATIVE OSP LIKE PROTEIN - HOMO SAPIENS (HUMAN).
Q60771 OLIGODENDROCYTE SPECIFIC PROTEIN - MUS MUSCULUS (MOUSE).
Q63400 RAT ORF, COMPLETE CDS - RATTUS NORVEGICUS (RAT).
Q90XQ8 CLAUDIN 19 - Brachydanio rerio (Zebrafish) (Zebra danio).
Q90XQ9 CLAUDIN A - Xenopus laevis (African clawed frog).
Q90XR0 CLAUDIN H - Brachydanio rerio (Zebrafish) (Zebra danio).
Q90XR2 CLAUDIN C - Brachydanio rerio (Zebrafish) (Zebra danio).
Q90XR4 CLAUDIN J - Brachydanio rerio (Zebrafish) (Zebra danio).
Q90XR5 CLAUDIN 11 - Brachydanio rerio (Zebrafish) (Zebra danio).
Q90XR6 CLAUDIN I - Brachydanio rerio (Zebrafish) (Zebra danio).
Q90XR7 CLAUDIN 10 - Brachydanio rerio (Zebrafish) (Zebra danio).
Q90XR8 CLAUDIN B - Brachydanio rerio (Zebrafish) (Zebra danio).
Q90XR9 CLAUDIN E - Brachydanio rerio (Zebrafish) (Zebra danio).
Q90XS0 CLAUDIN F - Brachydanio rerio (Zebrafish) (Zebra danio).
Q90XS1 CLAUDIN A - Brachydanio rerio (Zebrafish) (Zebra danio).
Q91X40 SIMILAR TO CLAUDIN 3 - Mus musculus (Mouse).
Q91Y55 PARACELLIN-1 - Rattus norvegicus (Rat).
Q91ZY9 CLAUDIN-18A2.2 - Mus musculus (Mouse).
Q91ZZ0 CLAUDIN-18A2.1 - Mus musculus (Mouse).
Q91ZZ1 CLAUDIN-18A1.2 - Mus musculus (Mouse).
Q925N4 PARACELLIN-1 - Mus musculus (Mouse).
Q96N78 CDNA FLJ31293 FIS, CLONE KIDNE2007569, MODERATELY SIMILAR TO CLAUDIN-10 - Homo sapiens (Human).
Q96PH4 CLAUDIN-18A2.1 - Homo sapiens (Human).
Q98SR1 CLAUDIN-5 - Gallus gallus (Chicken).
Q98SR2 CLAUDIN-3 - Gallus gallus (Chicken).
Q99P82 CLAUDIN-11 - Rattus norvegicus (Rat).
Q9CX57 6720456I16RIK PROTEIN - Mus musculus (Mouse).
Q9D7D7 2310014B08RIK PROTEIN (RIKEN CDNA 2310014B08 GENE) - Mus musculus (Mouse).
Q9D7U6 2210404A22RIK PROTEIN - Mus musculus (Mouse).
Q9D7Z0 2210009B08RIK PROTEIN - Mus musculus (Mouse).
Q9D8A6 2210009B08RIK PROTEIN - Mus musculus (Mouse).
Q9DB65 CLAUDIN 11 - Mus musculus (Mouse).
Q9DE12 TRANSMEMBRANE TIGHT JUNCTION PROTEIN CLAUDIN - Xenopus laevis (African clawed frog).
Q9N9W1 CLAUDIN - Halocynthia roretzi (Sea squirt).
Q9N9W2 PUTATIVE CLAUDIN - Halocynthia roretzi (Sea squirt).
Q9TUF7 PARACELLIN-1 - Bos taurus (Bovine).
Q9Z0G9 CPETR2 - MUS MUSCULUS (MOUSE).
Q9Z0S3 CLAUDIN-14 - MUS MUSCULUS (MOUSE).
Q9Z0S6 CLAUDIN-10 - MUS MUSCULUS (MOUSE).
Q9Z0S7 CLAUDIN-9 - MUS MUSCULUS (MOUSE).
Q9Z261 CLAUDIN-7 - MUS MUSCULUS (MOUSE).

Q8VC62 SIMILAR TO RIKEN CDNA 6720456I16 GENE - Mus musculus (Mouse).
Scan History
SPTR40_20f 3  300  NSINGLE    
Initial Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
ALCVIALLLALLGLLVAITGAQC O95484 82 82 -
ALCVVALLLALLGLLVAITGAQC Q9Z0S7 82 82 -
ALIVVAILLAAFGLLVALVGAQC O15551 81 81 -
ALIVVSILLAAFGLLVALVGAQC Q9Z0G9 81 81 -
ALVIISIIVAALGVLLSVVGGKC O19005 82 82 -
ALCVIALLVALFGLLVYLAGAKC CLD6_HUMAN 82 82 -
ALLVVAIVLAVLGLMVAIVGAQC Q98SR2 81 81 -
ALIVVSILLAAFGLLVALVGAQC Q63400 81 81 -
ALVIISIIVAALGVLLSVVGGKC O14493 82 82 -
ALMVISIIVGALGMLLSVVGGKC O35054 82 82 -
ALMVVSLVLGFLAMFVATMGMKC Q9Z261 82 82 -
ALTVICILVALLAMLVGIVGAKC Q90XQ9 82 82 -
ALCIISILVGVVGILLAAAGGKC Q90XS1 82 82 -
ALTVISIVIGVMGIMLSMAGGKC Q90XR8 82 82 -
ALMVVSLVLGFLAMFVATMGMKC O95471 82 82 -
ALCVVTLLIVLLGLLVYLAGAKC CLD6_MOUSE 82 82 -
ALTVICILVALLAMFIGIVGAKC Q9DE12 82 82 -
ALMVVGILLGVIAIFVATVGMKC O95832 82 82 -
ALMITAILLGFLGLLLGIAGLRC CLDF_HUMAN 80 80 -
ALVVIAIIVSFFALILGIAGGKC Q90XR9 82 82 -
ALTVSAVLLAFVALFVTLAGAQC O00501 82 82 -
ALVVISIIVTFMGVFLTIAGGKC CLDY_BRARE 82 82 -
ALMVIGILLGLIAIFVSTIGMKC O88551 82 82 -
ALMIVGIVLGVIGILVSIFALKC CLDI_MOUSE 81 81 -
ALMVIGILLGLIAIFVSTIGMKC CLD1_RAT 82 82 -
GLMIAAVSLGFFGSIFALFGMKC P78369 81 81 -
GLMIAAVSLGFFGSIFALFGMKC Q9Z0S6 81 81 -
ALTVGAVLLALVALFVTLTGAQC O54942 82 82 -
ALVVVAIIVGVLALFVAIVGAKC Q90XR2 82 82 -
ALMIVGIVLGAIGLLVSIFALKC CLDI_HUMAN 81 81 -
AMTVIAIILAVLGVMISVMGAKC Q90XR0 81 81 -
ALMCVAVALSLIALLIGICGMKQ CLDH_HUMAN 82 82 -
ALVIISILIGFMGMLLTFIGGQC Q90XS0 82 82 -
ALTVIVALLGLVALMVTVVGAQC Q98SR1 82 82 -
ALMVISCLLSGIACACAVIGMKC O95500 82 82 -
ALMVISCLLSGMACACAVVGMKC Q9Z0S3 82 82 -
GLMCAASVLAFLAFMTAILGMKC CLD8_MOUSE 82 82 -
GLMLTGIFLCGLSTLVSFVGMKC Q90XQ8 82 82 -
GLMCAASVMSFLAFMMAILGMKC CLD8_HUMAN 82 82 -
ALVIIALLLGLVGLVLSTMGLNC Q90XR7 80 80 -
AILVISAIVGLIAMFASFAGGKC CLDZ_BRARE 81 81 -
ALMVVAILLTVAGLGVASMGMKC CLDX_BRARE 82 82 -
GLIVTTMALASLAFLIFLIGADC Q90XR4 79 79 -
ALMIAASVLGLPAILLLLTVLPC O75508 83 83 -
AMMVTSSAISSLACIISVVGMRC CLD2_HUMAN 82 82 -
ALMIAASVLGLPAILLLLTVLPC Q60771 83 83 -
AMMVTSSAMSSLACIISVVGMRC O88552 82 82 -
AMTIISCMLSVLSLLILCGGADF Q90XR6 82 82 -
ALMITADILAGFGFLTLLLGLDC CLDG_HUMAN 150 150 -
ALMITADILAGFGFITLLLGLDC CLDG_BOVIN 99 99 -
ATTLLSLLLGFFGILLAIFGLSC Q9N9W1 82 82 -
ATMVLACVLSALGICTSTVGMKC CLDJ_HUMAN 82 82 -
VFMVICTIGTWLGLLLCVLGDWR CLDD_MOUSE 81 81 -
VLMVSASLLGLPALALLLLAMPC Q90XR5 83 83 -

Motif 2 width=22
Element Seqn Id St Int Rpt
ARIVLTAGVILLLAGILVLIPV O95484 115 10 -
ARIVLTAGVLLLLSGILVLIPV Q9Z0S7 115 10 -
AKITIVAGVLFLLAALLTLVPV O15551 114 10 -
AKITIVAGVLFLLAALLTLVPV Q9Z0G9 114 10 -
AKTMIVAGVVFLLAGLLVIVPV O19005 115 10 -
ARLVLTSGIVFVISGVLTLIPV CLD6_HUMAN 115 10 -
AKITIVSGVIFLLSGIMTLIPV Q98SR2 114 10 -
AKITIVAGVLFLLAAVLTLVPV Q63400 114 10 -
AKTMIVAGVVFLLAGLMVIVPV O14493 115 10 -
AKIMITAGAVFIVASMLIMVPV O35054 115 10 -
ARIAMTGGIVFIVAGLAALVAC Q9Z261 116 11 -
AKVSMVSGVVFLVAGILMLIPV Q90XQ9 115 10 -
AKVCVISGAIFIVAGVLCLIPV Q90XS1 115 10 -
AKVGITAGVIFIISGVLCLVPV Q90XR8 115 10 -
ARIAMGGGIIFIVAGLAALVAC O95471 116 11 -
SRLVLISGIIFVISGVLTLIPV CLD6_MOUSE 115 10 -
AKVSMVSGIVFLVAGILMLIPV Q9DE12 115 10 -
MRMAVIGGAIFLLAGLAILVAT O95832 116 11 -
AKLAATAGALHILAGICGMVAI CLDF_HUMAN 114 11 -
AKVSIASGVIFIIAGVLVLVPV Q90XR9 115 10 -
ARVALTGGVLYLFCGLLALVPL O00501 115 10 -
AKVVVAAGVFFLVGGILCLIPV CLDY_BRARE 115 10 -
MWMAVIGGIIFLISGLATLVAT O88551 116 11 -
AKMTLTSGILFIISGICAIIGV CLDI_MOUSE 115 11 -
MWMAVIGGIIFVISGLAILVAT CLD1_RAT 116 11 -
AKIACLAGIVFILSGLCSMTGC P78369 114 10 -
AKIACLAGIVFILSGLCSMTGC Q9Z0S6 114 10 -
ARVALTGGALYAVCGLLALVPL O54942 115 10 -
ARVMISSGAAFITASVLQLIPV Q90XR2 115 10 -
ANMTLTSGIMFIVSGLCAIAGV CLDI_HUMAN 115 11 -
AKVMIVSGIMFIIAGILDLIPS Q90XR0 114 10 -
AYLLGTSGVLFILTGIFVLIPV CLDH_HUMAN 116 11 -
AKVLILGGILCIVAGVLLLIPV Q90XS0 115 10 -
SRIVIAGGTIYILCGVLVLVPL Q98SR1 115 10 -
TTFAILGGTLFILAGLLCMVAV O95500 115 10 -
TTFAVLGGALFLLAGLLCMVAV Q9Z0S3 115 10 -
SRILLTAGIIFFITGLVVLIPV CLD8_MOUSE 116 11 -
SKVALAGGVLFITGGLFALIAT Q90XQ8 116 11 -
AHILLTAGIIFIITGMVVLIPV CLD8_HUMAN 116 11 -
GKNMFIGGIIYLIGGLCTMVGV Q90XR7 114 11 -
ALVATTGGVAFIIAGILGLVPP CLDZ_BRARE 114 10 -
SRIAMTGGIILSVGALCSIVAC CLDX_BRARE 116 11 -
GRIVVVSGITFMLSGLTTVVPV Q90XR4 112 10 -
YRRAQLAGVLLILLALCALVAT O75508 117 11 -
DRVAVAGGVFFILGGLLGFIPV CLD2_HUMAN 115 10 -
YRRAQLAGVLLILLALCAIVAT Q60771 117 11 -
DRVAVVGGVFFILGGILGFIPV O88552 115 10 -
PKVTLVSAIGLILAGLLVIIPV Q90XR6 115 10 -
VRICFVAGATLLIAGTPGIIGS CLDG_HUMAN 184 11 -
VRISFVAGTTLLIAGAPGIIGS CLDG_BOVIN 133 11 -
ARMVVASGMLHVAGGVSLGTGV Q9N9W1 116 11 -
SHASFAGGVCFMSAGISSLIST CLDJ_HUMAN 115 10 -
ENLLKVAGGMFLSVGLLMLVPL CLDD_MOUSE 114 10 -
HRRAVQGGLIILVISLCGMVST Q90XR5 117 11 -

Motif 3 width=25
Element Seqn Id St Int Rpt
KRELGASLYLGWAAAALLMLGGGLL O95484 157 20 -
KRELGASLYLGWAAAALLMLGGGLL Q9Z0S7 157 20 -
KREMGAGLYVGWAAAALQLLGGALL O15551 156 20 -
KREMGAGLYVGWAAAALQLLGGALL Q9Z0G9 156 20 -
KREMGASLYVGWAASGLLLLGGGLL O19005 157 20 -
KRELGASLYLGWAASGLLLLGGGLL CLD6_HUMAN 157 20 -
KRELGTSLYVGWAASALLLFGGALL Q98SR2 156 20 -
KREMGTGLYVGWAAAALQLLGGALL Q63400 156 20 -
KREMGASLYVGWAASGLLLLGGGLL O14493 157 20 -
KREMGASLYVGWAASGLLLLGGGLL O35054 157 20 -
KYEFGPAIFIGWAGSALVLLGGALL Q9Z261 158 20 -
KRELGAAIYIGWASSALMLLGGGLL Q90XQ9 157 20 -
KRELGASLFIGWGASALLIIGGSLL Q90XS1 157 20 -
KREIGASLYIGWGASALLIIGGSLL Q90XR8 157 20 -
KYEFGPAIFIGWAGSALVILGGALL O95471 158 20 -
KRELGASLYLGWAASGLLLLGGGLL CLD6_MOUSE 157 20 -
KRELGAALYIRWASSALLLLGGSLL Q9DE12 157 20 -
RYEFGQALFTGWAAASLCLLGGALL O95832 158 20 -
KYELGPALYLGWSASLISILGGLCL CLDF_HUMAN 155 19 -
RREMGASLYIGWGVAALLIIGGGIL Q90XR9 157 20 -
KYELGAALYIGWAATALLMVGGCLL O00501 157 20 -
KRELGASLFIGWCASGLLLLGGALL CLDY_BRARE 157 20 -
RYEFGQALFTGWAAASLCLLGGVLL O88551 158 20 -
RYTFGAALFVGWVAGGLTLIGGVMM CLDI_MOUSE 171 34 -
RYEFGQALFTGWAAASLCLLGGALL CLD1_RAT 158 20 -
KYELGAALFIGWAGASLCIIGGVIF P78369 155 19 -
KYELGAALFIGWAGASLCIIGGVIF Q9Z0S6 155 19 -
KYELGAALYIGWAASALLMCGGGLV O54942 157 20 -
KMEIGASLYLGWAASAMLLVGGSIL Q90XR2 157 20 -
RYTFGAALFVGWVAGGLTLIGGVMM CLDI_HUMAN 168 31 -
QRELGASIYIGFAAAALLIIGGAML Q90XR0 156 20 -
KRELGAALFLGWASAAVLFIGGGLL CLDH_HUMAN 158 20 -
KRELGASIYVGWGASAFLLFGGIIL Q90XS0 157 20 -
KREIGAALYIGWAATALLLFGGCLI Q98SR1 157 20 -
KFEIGQALYLGFISSSLSLIGGTLL O95500 157 20 -
KFEIGQALYLGFISSSLSLIGGTLL Q9Z0S3 157 20 -
KRELGEALYIGWTTALVLIAGGALF CLD8_MOUSE 158 20 -
RYEFGKALYVGWGSSALSIIGGSLL Q90XQ8 158 20 -
KRELGEALYLGWTTALVLIVGGALF CLD8_HUMAN 158 20 -
RFELGSGLYIGWAGAALCMLGGGFQ Q90XR7 155 19 -
KREFGAAIFICWGAAVLLVIGGGLL CLDZ_BRARE 156 20 -
KYEFGAAIFIAWAGAFLDIMGGGML CLDX_BRARE 158 20 -
KREMGAALYVGWLTAGFLFVGGAIL Q90XR4 154 20 -
IVSFGYSLYAGWIGAVLCLVGGCVI O75508 151 12 -
KFEIGEALYLGIISSLFSLIAGIIL CLD2_HUMAN 157 20 -
IVSFGYSLYAGWIGAVMCLVGGCVI Q60771 151 12 -
KFEIGEALYLGIISALFSLVAGVIL O88552 157 20 -
KRELGPCIYIGWASGVLLILAGGLL Q90XR6 157 20 -
QYKFGWSCWLGMAGSLGCFLAGAVL CLDG_HUMAN 229 23 -
QYKFGWSCWLGMAGSLGCFLAGAIL CLDG_BOVIN 178 23 -
RYVYGEALFVGWAAMVVGILGGIAM Q9N9W1 159 21 -
KHEPGGAIYIGFISAMLLFISGMIF CLDJ_HUMAN 157 20 -
KVQMGSSLSLAWTSSLLLLLGGILL CLDD_MOUSE 156 20 -
LMSFGFSLYAGWVGSALCFFAGSVM Q90XR5 149 10 -
Final Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
ALCVIALLLALLGLLVAITGAQC O95484 82 82 -
ALCVVALLLALLGLLVAITGAQC Q9Z0S7 82 82 -
ALIVVAILLAAFGLLVALVGAQC O15551 81 81 -
ALIVVSILLAAFGLLVALVGAQC Q9Z0G9 81 81 -
ALVIISIIVAALGVLLSVVGGKC O19005 82 82 -
ALCVIALLVALFGLLVYLAGAKC CLD6_HUMAN 82 82 -
ALLVVAIVLAVLGLMVAIVGAQC Q98SR2 81 81 -
ALIVVSILLAAFGLLVALVGAQC Q63400 81 81 -
ALVIISIIVAALGVLLSVVGGKC O14493 82 82 -
ALMVISIIVGALGMLLSVVGGKC O35054 82 82 -
ALMVVSLVLGFLAMFVATMGMKC Q9Z261 82 82 -
ALTVICILVALLAMLVGIVGAKC Q90XQ9 82 82 -
ALCIISILVGVVGILLAAAGGKC Q90XS1 82 82 -
ALTVISIVIGVMGIMLSMAGGKC Q90XR8 82 82 -
ALMVVSLVLGFLAMFVATMGMKC O95471 82 82 -
ALCVVTLLIVLLGLLVYLAGAKC CLD6_MOUSE 82 82 -
ALTVICILVALLAMFIGIVGAKC Q9DE12 82 82 -
ALMVVGILLGVIAIFVATVGMKC O95832 82 82 -
ALMITAILLGFLGLLLGIAGLRC CLDF_HUMAN 80 80 -
ALVVIAIIVSFFALILGIAGGKC Q90XR9 82 82 -
ALTVSAVLLAFVALFVTLAGAQC O00501 82 82 -
ALVVISIIVTFMGVFLTIAGGKC CLDY_BRARE 82 82 -
ALMVIGILLGLIAIFVSTIGMKC O88551 82 82 -
ALMIVGIVLGVIGILVSIFALKC CLDI_MOUSE 81 81 -
ALMIVGIVLGVIGILVSIFALKC Q91ZY9 81 81 -
ALMIVGIVLGVIGILVSIFALKC Q91ZZ0 81 81 -
ALMIVGIVLGVIGILVSIFALKC Q91ZZ1 81 81 -
ALMVIGILLGLIAIFVSTIGMKC CLD1_RAT 82 82 -
GLMIAAVSLGFFGSIFALFGMKC P78369 81 81 -
GLMIAAVSLGFFGSIFALFGMKC Q9Z0S6 81 81 -
GLMIAAVSLGFFGSIFALFGMKC Q96N78 79 79 -
GLMIAAVSLGFFGSIFALFGMKC Q9CX57 79 79 -
ALTVGAVLLALVALFVTLTGAQC O54942 82 82 -
ALVVVAIIVGVLALFVAIVGAKC Q90XR2 82 82 -
ALMITAILLGFLGLFLGMVGLRC Q9D7Z0 80 80 -
ALMITAILLGFLGLFLGMVGLRC Q9D8A6 80 80 -
ALMIVGIVLGAIGLLVSIFALKC CLDI_HUMAN 81 81 -
ALMIVGIVLGAIGLLVSIFALKC Q96PH4 81 81 -
AMTVIAIILAVLGVMISVMGAKC Q90XR0 81 81 -
ALMCVAVALSLIALLIGICGMKQ CLDH_HUMAN 82 82 -
ALVIISILIGFMGMLLTFIGGQC Q90XS0 82 82 -
ALTVIVALLGLVALMVTVVGAQC Q98SR1 82 82 -
ALMVISCLLSGIACACAVIGMKC O95500 82 82 -
ALMVISCLLSGMACACAVVGMKC Q9Z0S3 82 82 -
GLMCAASVLAFLAFMTAILGMKC CLD8_MOUSE 82 82 -
GLMLTGIFLCGLSTLVSFVGMKC Q90XQ8 82 82 -
QCKMYDSLLAAFGLLVALVGAQC Q91X40 62 62 -
GLMCAASVMSFLAFMMAILGMKC CLD8_HUMAN 82 82 -
ALVIIALLLGLVGLVLSTMGLNC Q90XR7 80 80 -
AILVISAIVGLIAMFASFAGGKC CLDZ_BRARE 81 81 -
ALMVVAILLTVAGLGVASMGMKC CLDX_BRARE 82 82 -
GLIVTTMALASLAFLIFLIGADC Q90XR4 79 79 -
ALMIAASVLGLPAILLLLTVLPC O75508 83 83 -
ALMIAASVLGLPGILLLLTVLPC Q99P82 83 83 -
AMMVTSSAISSLACIISVVGMRC CLD2_HUMAN 82 82 -
ALMIAASVLGLPAILLLLTVLPC Q60771 83 83 -
ALMIAASVLGLPAILLLLTVLPC Q9DB65 83 83 -
AMMVTSSAMSSLACIISVVGMRC O88552 82 82 -
VLMSLCNGLGLLGLLASGCGLDC Q9D7U6 82 82 -
AMTIISCMLSVLSLLILCGGADF Q90XR6 82 82 -
ALMITADILAGFGFLTLLLGLDC CLDG_HUMAN 150 150 -
ALMITADILAGFGFITLLLGLDC Q91Y55 80 80 -
ALMITADILAGFGFITLLLGLDC Q925N4 80 80 -
ALMITADILAGFGFITLLLGLDC CLDG_BOVIN 99 99 -
ALMITADILAGFGFITLLLGLDC Q9TUF7 80 80 -
GLMITSLATTALGLLLASLGVRC Q9D7D7 82 82 -
ATTLLSLLLGFFGILLAIFGLSC Q9N9W1 82 82 -
ATTLLSLLLGFFGILLAIFGLSC Q9N9W2 82 82 -
ATMVLACVLSALGICTSTVGMKC CLDJ_HUMAN 82 82 -
VFMVICTIGTWLGLLLCVLGDWR CLDD_MOUSE 81 81 -
VLMVSASLLGLPALALLLLAMPC Q90XR5 83 83 -

Motif 2 width=22
Element Seqn Id St Int Rpt
ARIVLTAGVILLLAGILVLIPV O95484 115 10 -
ARIVLTAGVLLLLSGILVLIPV Q9Z0S7 115 10 -
AKITIVAGVLFLLAALLTLVPV O15551 114 10 -
AKITIVAGVLFLLAALLTLVPV Q9Z0G9 114 10 -
AKTMIVAGVVFLLAGLLVIVPV O19005 115 10 -
ARLVLTSGIVFVISGVLTLIPV CLD6_HUMAN 115 10 -
AKITIVSGVIFLLSGIMTLIPV Q98SR2 114 10 -
AKITIVAGVLFLLAAVLTLVPV Q63400 114 10 -
AKTMIVAGVVFLLAGLMVIVPV O14493 115 10 -
AKIMITAGAVFIVASMLIMVPV O35054 115 10 -
ARIAMTGGIVFIVAGLAALVAC Q9Z261 116 11 -
AKVSMVSGVVFLVAGILMLIPV Q90XQ9 115 10 -
AKVCVISGAIFIVAGVLCLIPV Q90XS1 115 10 -
AKVGITAGVIFIISGVLCLVPV Q90XR8 115 10 -
ARIAMGGGIIFIVAGLAALVAC O95471 116 11 -
SRLVLISGIIFVISGVLTLIPV CLD6_MOUSE 115 10 -
AKVSMVSGIVFLVAGILMLIPV Q9DE12 115 10 -
MRMAVIGGAIFLLAGLAILVAT O95832 116 11 -
AKLAATAGALHILAGICGMVAI CLDF_HUMAN 114 11 -
AKVSIASGVIFIIAGVLVLVPV Q90XR9 115 10 -
ARVALTGGVLYLFCGLLALVPL O00501 115 10 -
AKVVVAAGVFFLVGGILCLIPV CLDY_BRARE 115 10 -
MWMAVIGGIIFLISGLATLVAT O88551 116 11 -
AKMTLTSGILFIISGICAIIGV CLDI_MOUSE 115 11 -
AKMTLTSGILFIISGICAIIGV Q91ZY9 115 11 -
AKMTLTSGILFIISGICAIIGV Q91ZZ0 115 11 -
AKMTLTSGILFIISGICAIIGV Q91ZZ1 115 11 -
MWMAVIGGIIFVISGLAILVAT CLD1_RAT 116 11 -
AKIACLAGIVFILSGLCSMTGC P78369 114 10 -
AKIACLAGIVFILSGLCSMTGC Q9Z0S6 114 10 -
AKIACLAGIVFILSGLCSMTGC Q96N78 112 10 -
AKIACLAGIVFILSGLCSMTGC Q9CX57 112 10 -
ARVALTGGALYAVCGLLALVPL O54942 115 10 -
ARVMISSGAAFITASVLQLIPV Q90XR2 115 10 -
AKLLAIAGTLHILAGACGMVAI Q9D7Z0 114 11 -
AKLLAIAGTLHILAGACGMVAI Q9D8A6 114 11 -
ANMTLTSGIMFIVSGLCAIAGV CLDI_HUMAN 115 11 -
ANMTLTSGIMFIVSGLCAIAGV Q96PH4 115 11 -
AKVMIVSGIMFIIAGILDLIPS Q90XR0 114 10 -
AYLLGTSGVLFILTGIFVLIPV CLDH_HUMAN 116 11 -
AKVLILGGILCIVAGVLLLIPV Q90XS0 115 10 -
SRIVIAGGTIYILCGVLVLVPL Q98SR1 115 10 -
TTFAILGGTLFILAGLLCMVAV O95500 115 10 -
TTFAVLGGALFLLAGLLCMVAV Q9Z0S3 115 10 -
SRILLTAGIIFFITGLVVLIPV CLD8_MOUSE 116 11 -
SKVALAGGVLFITGGLFALIAT Q90XQ8 116 11 -
AKITIVAGVLFLLAALLTLVPV Q91X40 95 10 -
AHILLTAGIIFIITGMVVLIPV CLD8_HUMAN 116 11 -
GKNMFIGGIIYLIGGLCTMVGV Q90XR7 114 11 -
ALVATTGGVAFIIAGILGLVPP CLDZ_BRARE 114 10 -
SRIAMTGGIILSVGALCSIVAC CLDX_BRARE 116 11 -
GRIVVVSGITFMLSGLTTVVPV Q90XR4 112 10 -
YRRAQLAGVLLILLALCALVAT O75508 117 11 -
YRRAQLAGVLLILLALCAIVAT Q99P82 117 11 -
DRVAVAGGVFFILGGLLGFIPV CLD2_HUMAN 115 10 -
YRRAQLAGVLLILLALCAIVAT Q60771 117 11 -
YRRAQLAGVLLILLALCAIVAT Q9DB65 117 11 -
DRVAVVGGVFFILGGILGFIPV O88552 115 10 -
KRLLTLGGTLLWTSGVMVLVPV Q9D7U6 116 11 -
PKVTLVSAIGLILAGLLVIIPV Q90XR6 115 10 -
VRICFVAGATLLIAGTPGIIGS CLDG_HUMAN 184 11 -
VRLCFVAGTVLLIAGTPGIIGS Q91Y55 114 11 -
VRLCFVAGTTLLIAGTPGIIGS Q925N4 114 11 -
VRISFVAGTTLLIAGAPGIIGS CLDG_BOVIN 133 11 -
VRISFVAGTTLLIAGAPGIIGS Q9TUF7 114 11 -
YGLAGLSGVVFFVAGLFSLIPV Q9D7D7 111 6 -
ARMVVASGMLHVAGGVSLGTGV Q9N9W1 116 11 -
ARMVVASGMLHVAGGVSLGTGV Q9N9W2 116 11 -
SHASFAGGVCFMSAGISSLIST CLDJ_HUMAN 115 10 -
ENLLKVAGGMFLSVGLLMLVPL CLDD_MOUSE 114 10 -
HRRAVQGGLIILVISLCGMVST Q90XR5 117 11 -

Motif 3 width=25
Element Seqn Id St Int Rpt
KRELGASLYLGWAAAALLMLGGGLL O95484 157 20 -
KRELGASLYLGWAAAALLMLGGGLL Q9Z0S7 157 20 -
KREMGAGLYVGWAAAALQLLGGALL O15551 156 20 -
KREMGAGLYVGWAAAALQLLGGALL Q9Z0G9 156 20 -
KREMGASLYVGWAASGLLLLGGGLL O19005 157 20 -
KRELGASLYLGWAASGLLLLGGGLL CLD6_HUMAN 157 20 -
KRELGTSLYVGWAASALLLFGGALL Q98SR2 156 20 -
KREMGTGLYVGWAAAALQLLGGALL Q63400 156 20 -
KREMGASLYVGWAASGLLLLGGGLL O14493 157 20 -
KREMGASLYVGWAASGLLLLGGGLL O35054 157 20 -
KYEFGPAIFIGWAGSALVLLGGALL Q9Z261 158 20 -
KRELGAAIYIGWASSALMLLGGGLL Q90XQ9 157 20 -
KRELGASLFIGWGASALLIIGGSLL Q90XS1 157 20 -
KREIGASLYIGWGASALLIIGGSLL Q90XR8 157 20 -
KYEFGPAIFIGWAGSALVILGGALL O95471 158 20 -
KRELGASLYLGWAASGLLLLGGGLL CLD6_MOUSE 157 20 -
KRELGAALYIRWASSALLLLGGSLL Q9DE12 157 20 -
RYEFGQALFTGWAAASLCLLGGALL O95832 158 20 -
KYELGPALYLGWSASLISILGGLCL CLDF_HUMAN 155 19 -
RREMGASLYIGWGVAALLIIGGGIL Q90XR9 157 20 -
KYELGAALYIGWAATALLMVGGCLL O00501 157 20 -
KRELGASLFIGWCASGLLLLGGALL CLDY_BRARE 157 20 -
RYEFGQALFTGWAAASLCLLGGVLL O88551 158 20 -
RYTFGAALFVGWVAGGLTLIGGVMM CLDI_MOUSE 171 34 -
RYTFGAALFVGWVAGGLTLIGGVMM Q91ZY9 171 34 -
RYTFGAALFVGWVAGGLTLIGGVMM Q91ZZ0 171 34 -
RYTFGAALFVGWVAGGLTLIGGVMM Q91ZZ1 171 34 -
RYEFGQALFTGWAAASLCLLGGALL CLD1_RAT 158 20 -
KYELGAALFIGWAGASLCIIGGVIF P78369 155 19 -
KYELGAALFIGWAGASLCIIGGVIF Q9Z0S6 155 19 -
KYELGAALFIGWAGASLCIIGGVIF Q96N78 153 19 -
KYELGAALFIGWAGASLCIIGGVIF Q9CX57 153 19 -
KYELGAALYIGWAASALLMCGGGLV O54942 157 20 -
KMEIGASLYLGWAASAMLLVGGSIL Q90XR2 157 20 -
KYELGPALYLGWSASLLSILGGICV Q9D7Z0 155 19 -
KYELGPALYLGWSASLLSILGGICV Q9D8A6 155 19 -
RYTFGAALFVGWVAGGLTLIGGVMM CLDI_HUMAN 168 31 -
RYTFGAALFVGWVAGGLTLIGGVMM Q96PH4 168 31 -
QRELGASIYIGFAAAALLIIGGAML Q90XR0 156 20 -
KRELGAALFLGWASAAVLFIGGGLL CLDH_HUMAN 158 20 -
KRELGASIYVGWGASAFLLFGGIIL Q90XS0 157 20 -
KREIGAALYIGWAATALLLFGGCLI Q98SR1 157 20 -
KFEIGQALYLGFISSSLSLIGGTLL O95500 157 20 -
KFEIGQALYLGFISSSLSLIGGTLL Q9Z0S3 157 20 -
KRELGEALYIGWTTALVLIAGGALF CLD8_MOUSE 158 20 -
RYEFGKALYVGWGSSALSIIGGSLL Q90XQ8 158 20 -
KREMGAGLYVGWAAAALQLLGGALL Q91X40 137 20 -
KRELGEALYLGWTTALVLIVGGALF CLD8_HUMAN 158 20 -
RFELGSGLYIGWAGAALCMLGGGFQ Q90XR7 155 19 -
KREFGAAIFICWGAAVLLVIGGGLL CLDZ_BRARE 156 20 -
KYEFGAAIFIAWAGAFLDIMGGGML CLDX_BRARE 158 20 -
KREMGAALYVGWLTAGFLFVGGAIL Q90XR4 154 20 -
IVSFGYSLYAGWIGAVLCLVGGCVI O75508 151 12 -
IVSFGYSLYAGWIGAVMCLVGGCVI Q99P82 151 12 -
KFEIGEALYLGIISSLFSLIAGIIL CLD2_HUMAN 157 20 -
IVSFGYSLYAGWIGAVMCLVGGCVI Q60771 151 12 -
IVSFGYSLYAGWIGAVMCLVGGCVI Q9DB65 151 12 -
KFEIGEALYLGIISALFSLVAGVIL O88552 157 20 -
RWEFGEALFLGWFAGFCLVLGGCVL Q9D7U6 159 21 -
KRELGPCIYIGWASGVLLILAGGLL Q90XR6 157 20 -
QYKFGWSCWLGMAGSLGCFLAGAVL CLDG_HUMAN 229 23 -
QYKFGWSCWLGMAGSLGCFLAGALL Q91Y55 159 23 -
QYKFGWSCWLGMAGSLGCFLAGALL Q925N4 159 23 -
QYKFGWSCWLGMAGSLGCFLAGAIL CLDG_BOVIN 178 23 -
QYKFGWSCWLGMAGSLGCFLAGAIL Q9TUF7 159 23 -
TVQVSYSLVLGYLGSCLLLLGGFSL Q9D7D7 153 20 -
RYVYGEALFVGWAAMVVGILGGIAM Q9N9W1 159 21 -
RYVYGEALFVGWAAMVVGILGGIAM Q9N9W2 159 21 -
KHEPGGAIYIGFISAMLLFISGMIF CLDJ_HUMAN 157 20 -
KVQMGSSLSLAWTSSLLLLLGGILL CLDD_MOUSE 156 20 -
LMSFGFSLYAGWVGSALCFFAGSVM Q90XR5 149 10 -