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PR01011

Identifier
GLUTPROXDASE  [View Relations]  [View Alignment]  
Accession
PR01011
No. of Motifs
3
Creation Date
02-OCT-1998  (UPDATE 07-JUN-1999)
Title
Glutathione peroxidase family signature
Database References

PROSITE; PS00460 GLUTATHIONE_PEROXID_1; PS00763 GLUTATHIONE_PEROXID_2
BLOCKS; BL00460 GLUTATH
PFAM; PF00255 GSHPx
INTERPRO; IPR000889
PDB; 1GP1
SCOP; 1GP1
CATH; 1GP1
Literature References
1. ESHDAT, Y., HOLLAND, D., FALTIN, Z. AND BENHAYYIM, G.
Plant glutathione peroxidases.
PHYSIOLOGIA PLANTARUM 100 234-240 (1997).
 
2. BARNETT, Y.A. AND KING, C.M.
Investigation of antioxidant status, DNA-repair capacity and mutation as a
function of age in humans.
MUTATION RESEARCH-DNAGING GENETIC INSTABILITY AND AGING 338 115-128 (1995).
 
3. COOKSON, E., BLAXTER, M.L. AND SELKIRK, M.E.
Identification of the major soluble cuticular glycoprotein of lymphatic
filarial nematode parasites (gp29) as a secretory homolog of glutathione-
peroxidase.
PROC.NATL.ACAD.SCI.U.S.A. 89(13) 5837-5841 (1992).
 
4. EPP, O., LADENSTEIN, R. AND WENDEL, A.
The refined structure of the selenoenzyme glutathione peroxidase at 0.2nm
resolution.
EUR.J.BIOCHEMISTRY 133 51-69 (1983). 

Documentation
Glutathione peroxidase (GSHPx), an enzyme whose principal function is to
protect against damage from endogenously-formed hydroxyperoxides, catalyses
the reduction of hydroxyperoxides by glutathione [1,2]:
 
2 Glutathione + H(2)O(2) = oxidised Glutathione + 2H(2)O
 
In higher vertebrates, several forms of GSHPx are known, including: a
ubiquitous cytosolic form (GSHPx-1); a gastrointestinal cytosolic form
(GSHPx-GI); a plasma secreted form (GSHPx-P); and an epididymal secretory
form (GSHPx-EP). 
 
In filarial nematode parasites, the major soluble cuticular protein (gp29)
is a secreted GSHPx, which may provide a mechanism of resistance to the 
immune reaction of the mammalian host by neutralising the products of the
oxidative burst of leukocytes [3].
 
The E.coli protein btuE, a periplasmic protein involved in vitamin B12
transport, is evolutionarily related to GSHPxs, although the significance
of this relationship is unclear.
 
The structure of bovine seleno-glutathione peroxidase has been determined
[4]. The protein belongs to the alpha-beta class, with a 3-layer(aba)
sandwich architecture. 
 
GLUTPROXDASE is a 3-element fingerprint that provides a signature for the
glutathione peroxidase family. The fingerprint was derived from an initial
alignment of 19 sequences: the motifs were drawn from conserved regions
spanning the full alignment length - motif 1 spans the C-terminal end of
helix 2, strand 3 and the N-terminus of helix 3, and includes the region
encoded by PROSITE pattern GLUTATHIONE_PEROXID_1 (PS00460), which contains
the catalytic cysteine; motif 2 encompasses strand 4 and the N-terminus of
the following loop, and includes the region encoded by PROSITE pattern 
GLUTATHIONE_PEROXID_2 (PS00763); and motif 3 spans strand 6 and half of 
the preceding loop. Three iterations on OWL30.2 were required to reach 
convergence, at which point a true set comprising 66 sequences was
identified. Several partial matches were also found, all of which are
fragments or homologues that fail to match one of the motifs.
 
An update on SPTR37_9f identified a true set of 63 sequences, and 2
partial matches.
Summary Information
  63 codes involving  3 elements
2 codes involving 2 elements
Composite Feature Index
3636363
2121
123
True Positives
BSAA_BACSU    BTUE_ECOLI    GPXA_NEIME    GSHC_BOVIN    
GSHC_HUMAN GSHC_MOUSE GSHC_RABIT GSHC_RAT
GSHC_SCHMA GSHE_MACFA GSHE_MOUSE GSHE_RAT
GSHG_HUMAN GSHH_HUMAN GSHH_PIG GSHH_RAT
GSHH_YEAST GSHI_YEAST GSHJ_YEAST GSHP_BOVIN
GSHP_HUMAN GSHP_MOUSE GSHP_RAT GSHU_BRUMA
GSHU_DIRIM GSHU_WUCBA GSHY_ARATH GSHY_HELAN
GSHZ_CITSI GSHZ_HELAN GSHZ_NICSY O02621
O04922 O08368 O18994 O19985
O22448 O22850 O23814 O24031
O24296 O32770 O35560 O43381
O43787 O45183 O46607 O48646
O49069 O59858 O62327 O65156
O70325 O75715 O81717 P73824
P74250 Q21666 Q27742 Q64625
Q93204 Q95003 Q98234
True Positive Partials
Codes involving 2 elements
GSHX_HUMAN O43725
Sequence Titles
BSAA_BACSU  GLUTATHIONE PEROXIDASE HOMOLOG BSAA - BACILLUS SUBTILIS. 
BTUE_ECOLI VITAMIN B12 TRANSPORT PERIPLASMIC PROTEIN BTUE - ESCHERICHIA COLI.
GPXA_NEIME GLUTATHIONE PEROXIDASE HOMOLOG - NEISSERIA MENINGITIDIS.
GSHC_BOVIN GLUTATHIONE PEROXIDASE (EC 1.11.1.9) (GSHPX-1) (CELLULAR GLUTATHIONE PEROXIDASE) - BOS TAURUS (BOVINE).
GSHC_HUMAN GLUTATHIONE PEROXIDASE (EC 1.11.1.9) (GSHPX-1) (CELLULAR GLUTATHIONE PEROXIDASE) - HOMO SAPIENS (HUMAN).
GSHC_MOUSE GLUTATHIONE PEROXIDASE (EC 1.11.1.9) (GSHPX-1) (CELLULAR GLUTATHIONE PEROXIDASE) - MUS MUSCULUS (MOUSE).
GSHC_RABIT GLUTATHIONE PEROXIDASE (EC 1.11.1.9) (GSHPX-1) (CELLULAR GLUTATHIONE PEROXIDASE) - ORYCTOLAGUS CUNICULUS (RABBIT).
GSHC_RAT GLUTATHIONE PEROXIDASE (EC 1.11.1.9) (GSHPX-1) (CELLULAR GLUTATHIONE PEROXIDASE) - RATTUS NORVEGICUS (RAT).
GSHC_SCHMA GLUTATHIONE PEROXIDASE (EC 1.11.1.9) (GPX) - SCHISTOSOMA MANSONI (BLOOD FLUKE).
GSHE_MACFA EPIDIDYMAL SECRETORY GLUTATHIONE PEROXIDASE PRECURSOR (EC 1.11.1.9) - MACACA FASCICULARIS (CRAB EATING MACAQUE) (CYNOMOLGUS MONKEY).
GSHE_MOUSE EPIDIDYMAL SECRETORY GLUTATHIONE PEROXIDASE PRECURSOR (EC 1.11.1.9) (MAJOR ANDROGEN-REGULATED PROTEIN) (ARMEP24) - MUS MUSCULUS (MOUSE).
GSHE_RAT EPIDIDYMAL SECRETORY GLUTATHIONE PEROXIDASE PRECURSOR (EC 1.11.1.9) - RATTUS NORVEGICUS (RAT).
GSHG_HUMAN GLUTATHIONE PEROXIDASE-GASTROINTESTINAL (EC 1.11.1.9) (GSHPX-GI) (GLUTATHIONE PEROXIDASE-RELATED PROTEIN 2) (GPRP) - HOMO SAPIENS (HUMAN).
GSHH_HUMAN PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE (EC 1.11.1.9) (PHGPX) - HOMO SAPIENS (HUMAN).
GSHH_PIG PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE (EC 1.11.1.9) (PHGPX) - SUS SCROFA (PIG).
GSHH_RAT PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE (EC 1.11.1.9) (PHGPX) - RATTUS NORVEGICUS (RAT).
GSHH_YEAST GLUTATHIONE PEROXIDASE HOMOLOG YKL026C (EC 1.11.1.9) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
GSHI_YEAST GLUTATHIONE PEROXIDASE HOMOLOG YBR244W (EC 1.11.1.9) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
GSHJ_YEAST GLUTATHIONE PEROXIDASE HYR1 (EC 1.11.1.9) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
GSHP_BOVIN PLASMA GLUTATHIONE PEROXIDASE PRECURSOR (EC 1.11.1.9) (GSHPX-P) - BOS TAURUS (BOVINE).
GSHP_HUMAN PLASMA GLUTATHIONE PEROXIDASE PRECURSOR (EC 1.11.1.9) (GSHPX-P) - HOMO SAPIENS (HUMAN).
GSHP_MOUSE PLASMA GLUTATHIONE PEROXIDASE PRECURSOR (EC 1.11.1.9) (GSHPX-P) - MUS MUSCULUS (MOUSE).
GSHP_RAT PLASMA GLUTATHIONE PEROXIDASE PRECURSOR (EC 1.11.1.9) (GSHPX-P) - RATTUS NORVEGICUS (RAT).
GSHU_BRUMA CUTICULAR GLUTATHIONE PEROXIDASE PRECURSOR (EC 1.11.1.9) (CUTICULAR GLYCOPROTEIN GP29) (MAJOR SURFACE ANTIGEN GP29) (GP30) - BRUGIA MALAYI, AND BRUGIA PAHANGI.
GSHU_DIRIM GLUTATHIONE PEROXIDASE PRECURSOR (EC 1.11.1.9) - DIROFILARIA IMMITIS.
GSHU_WUCBA CUTICULAR GLUTATHIONE PEROXIDASE PRECURSOR (EC 1.11.1.9) (CUTICULAR GLYCOPROTEIN GP29) (MAJOR SURFACE ANTIGEN GP29) (GP30) - WUCHERERIA BANCROFTI.
GSHY_ARATH GLUTATHIONE PEROXIDASE HOMOLOG PRECURSOR (EC 1.11.1.9) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
GSHY_HELAN GLUTATHIONE PEROXIDASE 2 (EC 1.11.1.9) - HELIANTHUS ANNUUS (COMMON SUNFLOWER).
GSHZ_CITSI GLUTATHIONE PEROXIDASE HOMOLOG (EC 1.11.1.9) (SALT-ASSOCIATED PROTEIN) - CITRUS SINENSIS (SWEET ORANGE).
GSHZ_HELAN GLUTATHIONE PEROXIDASE 1 (EC 1.11.1.9) - HELIANTHUS ANNUUS (COMMON SUNFLOWER).
GSHZ_NICSY GLUTATHIONE PEROXIDASE HOMOLOG 6P229 (EC 1.11.1.9) - NICOTIANA SYLVESTRIS (WOOD TOBACCO).
O02621 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - CAENORHABDITIS ELEGANS.
O04922 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O08368 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - PSEUDOMONAS WISCONSINENSIS.
O18994 EPIDIDYMAL SECRETORY GLUTATHIONE PEROXIDASE PRECURSOR (EC 1.11.1.9) - SUS SCROFA (PIG).
O19985 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O22448 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - CHLAMYDOMONAS REINHARDTII.
O22850 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O23814 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - SPINACIA OLERACEA (SPINACH).
O24031 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - LYCOPERSICON ESCULENTUM (TOMATO).
O24296 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - PISUM SATIVUM (GARDEN PEA).
O32770 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - LACTOCOCCUS LACTIS.
O35560 PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE - MUS MUSCULUS (MOUSE).
O43381 GSHH_HUMAN (EC 1.11.1.9) (GLUTATHIONE PEROXIDASE) - HOMO SAPIENS (HUMAN).
O43787 PLASMA GLUTATHIONE PEROXIDASE PRECURSOR (EC 1.11.1.9) (GSHPX-P) - HOMO SAPIENS (HUMAN).
O45183 T09A12.2 PROTEIN - CAENORHABDITIS ELEGANS.
O46607 EPIDIDYMAL SECRETORY GLUTATHIONE PEROXIDASE PRECURSOR (EC 1.11.1.9) - CANIS FAMILIARIS (DOG).
O48646 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O49069 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - GOSSYPIUM HIRSUTUM (UPLAND COTTON).
O59858 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O62327 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - CAENORHABDITIS ELEGANS.
O65156 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - ZANTEDESCHIA AETHIOPICA (WHITE CALLA LILY).
O70325 PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE - MUS MUSCULUS (MOUSE).
O75715 EPIDIDYMAL SECRETORY GLUTATHIONE PEROXIDASE PRECURSOR (EC 1.11.1.9) - HOMO SAPIENS (HUMAN).
O81717 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) PRECURSOR - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P73824 GLUTATHIONE PEROXIDASE - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
P74250 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
Q21666 SIMILAR TO GLUTATHIONE PEROXIDASE. NCBI GI: 1255292 - CAENORHABDITIS ELEGANS.
Q27742 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - PLASMODIUM FALCIPARUM.
Q64625 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - RATTUS NORVEGICUS (RAT).
Q93204 C11E4.1 PROTEIN - CAENORHABDITIS ELEGANS.
Q95003 GLUTATHIONE PEROXIDASE (EC 1.11.1.9) - CAENORHABDITIS ELEGANS.
Q98234 MC066L - MOLLUSCUM CONTAGIOSUM VIRUS SUBTYPE 1 (MCVI).

GSHX_HUMAN GLUTATHIONE PEROXIDASE-RELATED PROTEIN 1 (EC 1.11.1.9) (GPRP) - HOMO SAPIENS (HUMAN).
O43725 DJ29K1.1 - HOMO SAPIENS (HUMAN).
Scan History
OWL30_2    3  75   NSINGLE    
SPTR37_9f 2 65 NSINGLE
Initial Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
LKGKVVLIVNVASKCGFT GSHI_YEAST 23 23 -
YKGKLLLIVNVASQCGLT GSHZ_CITSI 27 27 -
YAGKYVLFVNVASYCGLT GSHP_HUMAN 59 59 -
YAGKYILFVNVASYCGLT GSHP_BOVIN 59 59 -
YAGKYILFVNVASYCGLT GSHP_RAT 59 59 -
YRGKHVLFVNVATYCGLT GSHE_MOUSE 59 59 -
YAGKHVLFVNVATYCGLT GSHE_RAT 59 59 -
YAGKYILFVNVASYCGLT GSHP_MOUSE 59 59 -
LRGKVLLIENVASLCGTT GSHC_MOUSE 33 33 -
LRGKVLLIENVASLCGTT GSHC_RAT 33 33 -
YRGHVCLIVNVACKCGAT GSHC_SCHMA 29 29 -
YRGFVCIVTNVASQCGKT GSHH_HUMAN 32 32 -
YRGYVCIVTNVASQCGKT GSHH_PIG 32 32 -
YRGCVCIVTNVASQCGKT GSHH_RAT 32 32 -
LRGKVLLIENVASLCGTT GSHC_BOVIN 38 38 -
LRGKVLLIENVASLCGTT GSHC_HUMAN 33 33 -
LRGKVLLIENVASLCGTT GSHC_RABIT 32 32 -
LRNKVVLIVNVASHCAFT GSHH_YEAST 22 22 -
FRGRAVLIENVRSLCGTT GSHG_HUMAN 26 26 -

Motif 2 width=17
Element Seqn Id St Int Rpt
FVILGFPCNQFGKQEPG GSHI_YEAST 58 17 -
LEILAFPCNQFGAQEPG GSHZ_CITSI 63 18 -
LVILGFPCNQFGKQEPG GSHP_HUMAN 94 17 -
LVILGFPCNQFGKQEPG GSHP_BOVIN 94 17 -
LVILGFPCNQFGKQEPG GSHP_RAT 94 17 -
LVILGFPCNQFGKQEPG GSHE_MOUSE 94 17 -
LVILGFPCNQFGKQEPG GSHE_RAT 94 17 -
LVILGFPSNQFGKQEPG GSHP_MOUSE 94 17 -
LVVLGFPCNQFGHQENG GSHC_MOUSE 69 18 -
LVVLGFPCNQFGHQENG GSHC_RAT 69 18 -
LRILAFPCNQFGGQEPW GSHC_SCHMA 65 18 -
LRILAFPCNQFGKQEPG GSHH_HUMAN 68 18 -
LRILAFPCNQFGRQEPG GSHH_PIG 68 18 -
LRILAFPCNQFGRQEPG GSHH_RAT 68 18 -
LVVLGFPCNQFGHQENA GSHC_BOVIN 74 18 -
LVVLGFPCNQFGHQENA GSHC_HUMAN 69 18 -
LVVLGFPCNQFGHQENA GSHC_RABIT 68 18 -
LVIVAFPCGQFGNQEFE GSHH_YEAST 57 17 -
LVVLGFPCNQFGHQENC GSHG_HUMAN 61 17 -

Motif 3 width=10
Element Seqn Id St Int Rpt
IKWNFEKFLV GSHI_YEAST 124 49 -
IKWNFSKFLV GSHZ_CITSI 128 48 -
IRWNFEKFLV GSHP_HUMAN 179 68 -
IRWNFEKFLV GSHP_BOVIN 179 68 -
IRWNFEKFLV GSHP_RAT 179 68 -
IRWNFEKFLV GSHE_MOUSE 179 68 -
IRWNFEKFLV GSHE_RAT 179 68 -
IRWNFEKFLV GSHP_MOUSE 179 68 -
IAWNFEKFLV GSHC_MOUSE 158 72 -
ISWNFEKFLV GSHC_RAT 158 72 -
IKWNFSKFLV GSHC_SCHMA 130 48 -
IKWNFTKFLI GSHH_HUMAN 134 49 -
IKWNFTKFLI GSHH_PIG 134 49 -
IKWNFTKFLI GSHH_RAT 134 49 -
VSWNFEKFLV GSHC_BOVIN 163 72 -
VAWNFEKFLV GSHC_HUMAN 158 72 -
VSWSFEKFLV GSHC_RABIT 157 72 -
IKWNFEKFVV GSHH_YEAST 123 49 -
VAWNFEKFLI GSHG_HUMAN 150 72 -
Final Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
YKGKVLIIVNVASQCGLT GSHZ_NICSY 29 29 -
YKGKVLIIVNVASQCGLT O49069 29 29 -
FKGKVLLIVNVASRCGLT O65156 105 105 -
YKGKVLLIVNVASQCGFT GSHY_HELAN 40 40 -
YKGKVLLIVNVASQCGLT O48646 28 28 -
LKGKVVLIVNVASKCGFT GSHI_YEAST 23 23 -
YKGKLLLIVNVASQCGLT GSHZ_CITSI 27 27 -
YAGKYVLFVNVASYCGLT GSHP_HUMAN 59 59 -
YKGKVLLIVNVASQCGLT O23814 30 30 -
YAGKYILFVNVASYCGLT GSHP_BOVIN 59 59 -
YAGKYILFVNVASYCGLT GSHP_RAT 59 59 -
YKGKVLIIVNVASQCGLT O24031 29 29 -
LEGKAVLIVNVASKCGFT O22448 24 24 -
YRGKHVLFVNVATYCGLT GSHE_MOUSE 59 59 -
FKGKVLLIVNVASRCGLT O24296 97 97 -
FTGKVLLIVNVASKCGLT O22850 66 66 -
YAGKHVLFVNVATYCGLT GSHE_RAT 59 59 -
YQGKVLIIVNVASQCGLT O62327 22 22 -
YKGKVVLIVNVASKCGLT GSHZ_HELAN 27 27 -
YKGKTLLVVNVASKCGLT O04922 27 27 -
FKGKVMLIVNVASRCGLT GSHY_ARATH 97 97 -
FKGKVMLIVNVASRCGLT O19985 97 97 -
FKGKVMLIVNVASRCGLT O81717 97 97 -
YAGKYVLFVNVASYXGLT O43787 59 59 -
YAGKHVLFVNVATYCGLT O18994 57 57 -
LKGKVVLIVNVASKCGFT GSHJ_YEAST 22 22 -
YKGKVLIIVNVASQCGLT O02621 22 22 -
YAGKYILFVNVASYCGLT GSHP_MOUSE 59 59 -
YVGKHILFVNVATYCGLT GSHE_MACFA 59 59 -
YVGKHILFVNVATYCGLT O75715 59 59 -
LKGKVVLVVNTASKCGFT O59858 22 22 -
LRGKVLLIENVASLCGTT GSHC_MOUSE 33 33 -
LRGKVLLIENVASLCGTT GSHC_RAT 33 33 -
YAGKHILFVNVASFCGLT Q64625 59 59 -
FEGKVLLIVNTASQCGFT P74250 27 27 -
YRGHVCLIVNVACKCGAT GSHC_SCHMA 29 29 -
FAGNVLLIVNVASKCGLT BTUE_ECOLI 23 23 -
YRGFVCIVTNVASQCGKT GSHH_HUMAN 32 32 -
YPRKHVLFVNVATYCGLT O46607 59 59 -
YRGYVCIVTNVASQCGKT GSHH_PIG 32 32 -
YRGCVCIVTNVASQCGKT GSHH_RAT 32 32 -
YRGKVLLIVNTATRCGLT GPXA_NEIME 21 21 -
LRGKVLLIENVASLCGTT GSHC_BOVIN 38 38 -
LRGKVLLIENVASLCGTT GSHC_HUMAN 33 33 -
FAGKVLMIVNTASKCGFT BSAA_BACSU 21 21 -
YRGFVCIVTNVASQXGKT O43381 59 59 -
YRGFVCIVTNVASQXGKT O35560 59 59 -
YRGFVCIVTNVASQXGKT O70325 59 59 -
YRGKVLLLVNVATYCAYT GSHU_DIRIM 58 58 -
YKGKVVIVVNTASKCGFT O32770 21 21 -
YSGLVVIIVNVASYCGLT Q21666 51 51 -
YRNKVLLIVNVATYCAYT GSHU_BRUMA 60 60 -
YRNKVLLIVNVATYCAYT GSHU_WUCBA 60 60 -
IADKVVLFVNVASKCGLT P73824 20 20 -
LRGKVLLIENVASLCGTT GSHC_RABIT 32 32 -
LRGRVLLIENVASLXGST Q98234 50 50 -
YRDKVVLFTNVASYCGYT O45183 49 49 -
YRGKVILLVNVATFCAYT Q95003 59 59 -
LRNKVVLIVNVASHCAFT GSHH_YEAST 22 22 -
YRGQVLLMVNVATFCAYT Q93204 58 58 -
FRGRAVLIENVRSLCGTT GSHG_HUMAN 26 26 -
FKNKVLIIFNSASKCGLT Q27742 62 62 -
YAGKPLVVVNTASFCGFT O08368 47 47 -

Motif 2 width=17
Element Seqn Id St Int Rpt
LEILAFPCNQFGGQEPG GSHZ_NICSY 65 18 -
LEILAFPCNQFGGQEPG O49069 65 18 -
FEILAFPCNQFGSQEPG O65156 141 18 -
FEILAFPCNQFGGQEPG GSHY_HELAN 76 18 -
FEILAFPCNQFGNQEPG O48646 64 18 -
FVILGFPCNQFGKQEPG GSHI_YEAST 58 17 -
LEILAFPCNQFGAQEPG GSHZ_CITSI 63 18 -
LVILGFPCNQFGKQEPG GSHP_HUMAN 94 17 -
LEILAFPCNQFGNQEPG O23814 66 18 -
LVILGFPCNQFGKQEPG GSHP_BOVIN 94 17 -
LVILGFPCNQFGKQEPG GSHP_RAT 94 17 -
LEILAFPCNQFGGQEPG O24031 65 18 -
LVILGFPCNQFGGQEPG O22448 59 17 -
LVILGFPCNQFGKQEPG GSHE_MOUSE 94 17 -
LEVLAFPCNQFGMQEPG O24296 133 18 -
FEILAFPCNQFGSQEPG O22850 102 18 -
LVILGFPCNQFGKQEPG GSHE_RAT 94 17 -
LEVLAFPCNQFGGQEPS O62327 58 18 -
FEILAFPCNQFGQQEPG GSHZ_HELAN 63 18 -
LEILAFPCNQFLGQEPG O04922 63 18 -
FEILAFPCNQFGFQEPG GSHY_ARATH 133 18 -
FEILAFPCNQFGFQEPG O19985 133 18 -
FEILAFPCNQFGFQEPG O81717 133 18 -
LVILGFPCNQFGKQEPG O43787 94 17 -
LVVLGFPCNQFGKQEPG O18994 92 17 -
FTIIGFPCNQFGHQEPG GSHJ_YEAST 57 17 -
LEVLAFPCNQFAGQEPS O02621 58 18 -
LVILGFPSNQFGKQEPG GSHP_MOUSE 94 17 -
LVVLGFPCNQFGKQEPG GSHE_MACFA 94 17 -
LVVLGFPCNQFGKQEPG O75715 94 17 -
FIILGFPCNQFGNQEPG O59858 57 17 -
LVVLGFPCNQFGHQENG GSHC_MOUSE 69 18 -
LVVLGFPCNQFGHQENG GSHC_RAT 69 18 -
VSVLGFPCNQFGKQEPG Q64625 94 17 -
FTVLGFPCNQFGQQEPG P74250 62 17 -
LRILAFPCNQFGGQEPW GSHC_SCHMA 65 18 -
FMVLGFPCNQFLEQEPG BTUE_ECOLI 58 17 -
LRILAFPCNQFGKQEPG GSHH_HUMAN 68 18 -
LVVLGFPCNQFGKQGPG O46607 94 17 -
LRILAFPCNQFGRQEPG GSHH_PIG 68 18 -
LRILAFPCNQFGRQEPG GSHH_RAT 68 18 -
LEILDFPCNQFREQAPE GPXA_NEIME 56 17 -
LVVLGFPCNQFGHQENA GSHC_BOVIN 74 18 -
LVVLGFPCNQFGHQENA GSHC_HUMAN 69 18 -
LEILGFPCNQFMNQEPG BSAA_BACSU 56 17 -
LRILAFPCNQFGKQEPG O43381 95 18 -
LRILAFPCNQFGRQEPG O35560 95 18 -
LRILAFPCNQFGRQEPG O70325 95 18 -
LKILAFPCNQFLLQEPA GSHU_DIRIM 93 17 -
LEILGFPCNQFANQDAG O32770 56 17 -
LRVAAFPCNQFGFQACD Q21666 87 18 -
LNILGFPCNQFYLQEPA GSHU_BRUMA 95 17 -
LNILGFPCNQFYLQEPA GSHU_WUCBA 95 17 -
LVIIGVPCNQFGAQEPG P73824 55 17 -
LVVLGFPCNQFGHQENA GSHC_RABIT 68 18 -
LVVLGFPCNQFGHQENA Q98234 86 18 -
FRVAAFPCNQFEKQEPE O45183 85 18 -
LTLVAFPCNQFYLQEPA Q95003 94 17 -
LVIVAFPCGQFGNQEFE GSHH_YEAST 57 17 -
FTLIAFPCNQFYLQEPA Q93204 93 17 -
LVVLGFPCNQFGHQENC GSHG_HUMAN 61 17 -
LEILAFPTSQFLNQEFD Q27742 98 18 -
LEVLGVPSDDFRQESAD O08368 82 17 -

Motif 3 width=10
Element Seqn Id St Int Rpt
IKWNFSKFLV GSHZ_NICSY 130 48 -
IKWNFSKFLV O49069 131 49 -
IKWNFEKFLV O65156 206 48 -
IKWNFTKFLV GSHY_HELAN 141 48 -
IKWNFAKFLV O48646 129 48 -
IKWNFEKFLV GSHI_YEAST 124 49 -
IKWNFSKFLV GSHZ_CITSI 128 48 -
IRWNFEKFLV GSHP_HUMAN 179 68 -
LKWNFTKFLV O23814 131 48 -
IRWNFEKFLV GSHP_BOVIN 179 68 -
IRWNFEKFLV GSHP_RAT 179 68 -
IKWNFSKFLI O24031 130 48 -
IKWNFEKFLV O22448 124 48 -
IRWNFEKFLV GSHE_MOUSE 179 68 -
VKWNFEKFLV O24296 198 48 -
IKWNFAKFLV O22850 167 48 -
IRWNFEKFLV GSHE_RAT 179 68 -
IKWNFTKFLV O62327 123 48 -
IQWNFSKFLV GSHZ_HELAN 128 48 -
IKWNFTKFLV O04922 128 48 -
IKWNFEKFLI GSHY_ARATH 198 48 -
IKWNFEKFLI O19985 198 48 -
IKWNFEKFLI O81717 198 48 -
IRWNFEKFLV O43787 179 68 -
IRWNFEKFLV O18994 177 68 -
IKWNFEKFLV GSHJ_YEAST 123 49 -
IKWNFTKFLV O02621 123 48 -
IRWNFEKFLV GSHP_MOUSE 179 68 -
IRWNFEKFLV GSHE_MACFA 179 68 -
IRWNFEKFLV O75715 179 68 -
IKWNFEKFLV O59858 122 48 -
IAWNFEKFLV GSHC_MOUSE 158 72 -
ISWNFEKFLV GSHC_RAT 158 72 -
IRWNFEKFLV Q64625 179 68 -
IKWNFTKFLV P74250 133 54 -
IKWNFSKFLV GSHC_SCHMA 130 48 -
ILWNFEKFLV BTUE_ECOLI 143 68 -
IKWNFTKFLI GSHH_HUMAN 134 49 -
IRWNFEKFLV O46607 179 68 -
IKWNFTKFLI GSHH_PIG 134 49 -
IKWNFTKFLI GSHH_RAT 134 49 -
IKWNFTKFLV GPXA_NEIME 141 68 -
VSWNFEKFLV GSHC_BOVIN 163 72 -
VAWNFEKFLV GSHC_HUMAN 158 72 -
IKWNFTKFIV BSAA_BACSU 122 49 -
IKWNFTKFLI O43381 161 49 -
IKWNFTKFLI O35560 161 49 -
IKWNFTKFLI O70325 161 49 -
IIWNFEKFLI GSHU_DIRIM 180 70 -
IKWNFTKFLI O32770 121 48 -
IKWNFTKFLV Q21666 152 48 -
VIWNFEKFLV GSHU_BRUMA 182 70 -
VIWNFEKFLV GSHU_WUCBA 182 70 -
ISWNFGKFLI P73824 115 43 -
VSWSFEKFLV GSHC_RABIT 157 72 -
VAWNFEKFLV Q98234 175 72 -
IPWNFSKFLV O45183 150 48 -
ITWNFEKFLI Q95003 181 70 -
IKWNFEKFVV GSHH_YEAST 123 49 -
ITWNFEKFLI Q93204 180 70 -
VAWNFEKFLI GSHG_HUMAN 150 72 -
IGWNFGKFLV Q27742 167 52 -
PRWNFFKYVV O08368 141 42 -