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PR00937

Identifier
TBOX  [View Relations]  [View Alignment]  
Accession
PR00937
No. of Motifs
6
Creation Date
18-SEP-1998  (UPDATE 18-JUN-1999)
Title
T-Box domain signature
Database References
PRINTS; PR00938 BRACHYURY
PROSITE; PS01283 TBOX_1; PS01264 TBOX_2
BLOCKS; BL01283
PFAM; PF00907 T-box
INTERPRO; IPR001699
PDB; 1XBR
SCOP; 1XBR
CATH; 1XBR
Literature References
1. PAPAIOANNOU, V. E. AND SILVER L.M.
The T-box gene family.
BIOESSAYS 20(1) 9-19 (1998).
 
2. WATTLER, S., RUSS, A., EVANS, M. AND NEHLS, M.
A combined analysis of genomic and primary protein structure defines the
phylogenetic relationship of new members of the T-box family.
GENOMICS 48 24-33 (1998).
 
3. KAVKA, A.I. AND GREEN, J.B.A.
Tales of Tails: Brachyury and the T-box genes.
BIOCHIM.BIOPHYS.ACTA 1333 f73-f84 (1997).
 
4. PAPAIOANNOU, V.E.
T-box family reunion.
TRENDS GENET. 13(6) 212-213 (1997).

Documentation
The T-box gene family is an ancient group of putative transcription
factors that appear to play a critical role in the development of all
animal species.
 
These genes were uncovered on the basis of similarity to the DNA binding
domain [1] of murine Brachyury (T) gene product, which similarity is the
defining feature of the family. The Brachyury gene is named for its
phenotype, which was identified 70 years ago as a mutant mouse strain with
a short blunted tail. The gene, and its paralogues, have become a well-
studied model for the family, and hence much of what is known about the
T-box family is derived from the murine Brachyury gene.
 
Consistent with its nuclear location, Brachyury protein has a sequence-
specific DNA-binding activity and can act as a transcriptional regulator
[2]. Homozygous mutants for the gene undergo extensive developmental
anomalies, thus rendering the mutation lethal [3]. The postulated role of
Brachyury is as a transcription factor, regulating the specification and
differentiation of posterior mesoderm during gastrulation in a dose-
dependent manner [1].
 
Common features shared by T-box family members are, DNA-binding and
transcriptional regulatory activity, a role in development and conserved
expression patterns, most of the known genes in all species being expressed
in mesoderm of mesoderm precursors [4].
 
TBOX is a 6-element fingerprint that provides a signature for the T-box
domain. The fingerprint was derived from an initial alignment of 23
sequences: the motifs were drawn from conserved regions spanning the 
DNA-binding domain - motif 1 spans beta-strands 2-4 and includes part of
the region encoded by PROSITE pattern TBOX_1 (PS01283); motifs 2 and 3 span
part of the sequence encoded by PROSITE pattern TBOX_2 (PS01264), including
strands 8-11 and helix 2; motif 4 includes strand 13; and motif 5 spans
strand 15 and the N-terminal residues of helix 4. Two iterations on OWL30.2
were required to reach convergence, at which point a true set comprising 50
sequences was identified. Several partial matches were also found, all of
which are fragments.
 
An update on SPTR37_9f identified a true set of 46 sequences, and 7
partial matches.
Summary Information
  46 codes involving  6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
2 codes involving 2 elements
Composite Feature Index
6464646464646
5000000
4000000
3000000
2210010
123456
True Positives
BRA1_BRAFL    BRA2_BRAFL    BRAC_BRARE    BRAC_CHICK    
BRAC_HALRO BRAC_HEMPU BRAC_MOUSE BRAC_XENLA
BRC2_HALRO BYN_DROME EOMD_XENLA H15_DROME
O13161 O15178 O15301 O17212
O17276 O42100 O43435 O43436
O43891 O54840 O57386 O62535
O70306 O73718 O73719 O93288
O93303 O93389 OMB_DROME Q23467
TBR1_HUMAN TBR1_MOUSE TBX2_CAEEL TBX2_HUMAN
TBX2_MOUSE TBX5_HUMAN TBX6_BRARE TBX6_MOUSE
TBX8_CAEEL TBX9_CAEEL TBXT_CHICK TX12_CAEEL
VEGT_XENLA YPX4_CAEEL
True Positive Partials
Codes involving 2 elements
O02073 YS4A_CAEEL
Sequence Titles
BRA1_BRAFL  BRACHYURY PROTEIN HOMOLOG 1 (AMBRA-1) - BRANCHIOSTOMA FLORIDAE (FLORIDA LANCELET) (AMPHIOXUS). 
BRA2_BRAFL BRACHYURY PROTEIN HOMOLOG 2 (AMBRA-2) - BRANCHIOSTOMA FLORIDAE (FLORIDA LANCELET) (AMPHIOXUS).
BRAC_BRARE BRACHYURY PROTEIN HOMOLOG (T PROTEIN HOMOLOG) (T-BOX PROTEIN ZFT) (ZF- T) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
BRAC_CHICK BRACHYURY PROTEIN (T PROTEIN) - GALLUS GALLUS (CHICKEN).
BRAC_HALRO BRACHYURY PROTEIN HOMOLOG (T PROTEIN) (AS-T) - HALOCYNTHIA RORETZI (SEA SQUIRT).
BRAC_HEMPU BRACHYURY PROTEIN HOMOLOG (T PROTEIN) (HPTA) - HEMICENTROTUS PULCHERRIMUS (SEA URCHIN).
BRAC_MOUSE BRACHYURY PROTEIN (T PROTEIN) - MUS MUSCULUS (MOUSE).
BRAC_XENLA BRACHYURY PROTEIN (T PROTEIN) (XBRA) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
BRC2_HALRO T-BOX CONTAINING PROTEIN 2 (AS-T2) - HALOCYNTHIA RORETZI (SEA SQUIRT).
BYN_DROME T-RELATED PROTEIN (TRP) (BRACHYENTERON PROTEIN) - DROSOPHILA MELANOGASTER (FRUIT FLY).
EOMD_XENLA EOMESODERMIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
H15_DROME T-BOX PROTEIN H15 - DROSOPHILA MELANOGASTER (FRUIT FLY).
O13161 T-BOX PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O15178 BRACHYURY PROTEIN (T PROTEIN) - HOMO SAPIENS (HUMAN).
O15301 TRANSCRIPTION FACTOR TBX5 - HOMO SAPIENS (HUMAN).
O17212 H14A12.4 PROTEIN - CAENORHABDITIS ELEGANS.
O17276 T27A1.6 PROTEIN - CAENORHABDITIS ELEGANS.
O42100 ME-TAM - ORYZIAS LATIPES (MEDAKA FISH).
O43435 TBX1 PROTEIN (T-BOX PROTEIN 1) (TESTIS-SPECIFIC T-BOX PROTEIN) - HOMO SAPIENS (HUMAN).
O43436 TBX1 PROTEIN (T-BOX PROTEIN 1) (TESTIS-SPECIFIC T-BOX PROTEIN) - HOMO SAPIENS (HUMAN).
O43891 TRANSCRIPTION FACTOR T-BOX 5.
O54840 TBX15 PROTEIN (T-BOX PROTEIN 15) - MUS MUSCULUS (MOUSE).
O57386 BRACHYURY - CYNOPS PYRRHOGASTER (JAPANESE COMMON NEWT).
O62535 OPTOMOTOR-BLIND-RELATED PROTEIN-1 - DROSOPHILA MELANOGASTER (FRUIT FLY).
O70306 TBX15 PROTEIN (T-BOX PROTEIN 15) - MUS MUSCULUS (MOUSE).
O73718 T-BOX PROTEIN 3 (T-BOX TRANSCRIPTION FACTOR TBX3) - GALLUS GALLUS (CHICKEN).
O73719 T-BOX PROTEIN 5 (T-BOX TRANSCRIPTION FACTOR TBX5) - GALLUS GALLUS (CHICKEN).
O93288 T-BOX PROTEIN 4 (T-BOX TRANSCRIPTION FACTOR TBX4) - GALLUS GALLUS (CHICKEN).
O93303 T-BOX CONTAINING PROTEIN - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
O93389 SPADETAIL - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
OMB_DROME OPTOMOTOR-BLIND PROTEIN (LETHAL(1)OPTOMOTOR-BLIND) (L(1)OMB) (BIFID PROTEIN) - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q23467 COSMID ZK328 - CAENORHABDITIS ELEGANS.
TBR1_HUMAN T-BRAIN-1 PROTEIN (T-BOX BRAIN PROTEIN 1) (TBR-1) (TES-56) - HOMO SAPIENS (HUMAN).
TBR1_MOUSE T-BRAIN-1 PROTEIN (T-BOX BRAIN PROTEIN 1) (TBR-1) (TES-56) - MUS MUSCULUS (MOUSE).
TBX2_CAEEL T-BOX PROTEIN 2 - CAENORHABDITIS ELEGANS.
TBX2_HUMAN TBX2 PROTEIN (T-BOX PROTEIN 2) - HOMO SAPIENS (HUMAN).
TBX2_MOUSE TBX2 PROTEIN (T-BOX PROTEIN 2) - MUS MUSCULUS (MOUSE).
TBX5_HUMAN TBX5 PROTEIN (T-BOX PROTEIN 5) - HOMO SAPIENS (HUMAN).
TBX6_BRARE TBX6 PROTEIN (T-BOX PROTEIN 6) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
TBX6_MOUSE TBX6 PROTEIN (T-BOX PROTEIN 6) - MUS MUSCULUS (MOUSE).
TBX8_CAEEL T-BOX PROTEIN 8 - CAENORHABDITIS ELEGANS.
TBX9_CAEEL T-BOX PROTEIN 9 - CAENORHABDITIS ELEGANS.
TBXT_CHICK T-BOX CONTAINING PROTEIN TBXT - GALLUS GALLUS (CHICKEN).
TX12_CAEEL T-BOX PROTEIN 12 - CAENORHABDITIS ELEGANS.
VEGT_XENLA T-BOX PROTEIN VEGT (T-BOX PROTEIN BRAT) (T-BOX PROTEIN ANTIPODEAN) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
YPX4_CAEEL HYPOTHETICAL 36.5 KD PROTEIN F40H6 IN CHROMOSOME III - CAENORHABDITIS ELEGANS.

O02073 SIMILAR TO THE BRACHYURY PROTEIN - CAENORHABDITIS ELEGANS.
YS4A_CAEEL HYPOTHETICAL 21.5 KD PROTEIN ZK177.10 IN CHROMOSOME II - CAENORHABDITIS ELEGANS.
Scan History
OWL30_2    2  250  NSINGLE    
SPTR37_9f 3 200 NSINGLE
Initial Motifs
Motif 1  width=25
Element Seqn Id St Int Rpt
GTEMIITKSGRRMFPTVRVSFSGPL H15_DROME 178 178 -
DNEMVITVNGRRIFPTLEYTVTGLD YPX4_CAEEL 24 24 -
GTEMIVTKAGRRMFPTFQVKLFGMD TBX1_MOUSE 9 9 -
VNEMIVTKNGRKLFPKLEYIVEGLD YNS6_CAEEL 108 108 -
KNEMIVTKSGRKMFPKLEYVVRGLT YNS2_CAEEL 137 137 -
GTEMIITKKGRRMFPLVKLKLSGLD CELZK3286 410 410 -
GTEMVITKSGRRMFPPFKVRCSGLD TBX3_MOUSE 9 9 -
GTEMVITKSGRRMFPPFKVRVSGLD TBX2_HUMAN 112 112 -
GTEMVITKSGRRMFPPFKVRVSGLD TBX2_MOUSE 112 112 -
TNEMIVTKSGRRMFPVLKVNVSGLD BRA2_BRAFL 52 52 -
TNEMIVTKNGRRMFPVLKVNVSGLD BRA1_BRAFL 62 62 -
VTEMIITKAGRRMFPSYKVKVTGIN TBX5_HUMAN 68 68 -
TNEMIVTKTGRRMFPVLRASVTGLD BRAC_BRARE 52 52 -
QTEMIITKQGRRMFPFLSFNISGLD TBR1_HUMAN 221 221 -
GTEMVITKSGRQMFPQMKFRVSGLD OMB_DROME 345 345 -
GTEMIITKAGRRMFPACRVSVTGLD TBX6_MOUSE 108 108 -
GTEMLITKSGRRMFPSCKVTVTGLN TBX6_BRARE 51 51 -
QTEMIITKQGRRMFPFLSFNITGLN EOMD_XENLA 271 271 -
TNEMIVTKNGRRMFPVVKISASGLD BYN_DROME 104 104 -
TNEMIVTKSGRRMFPVLSASIAGLD BRAC_HEMPU 58 58 -
GTEMIITKSGRRMFPQCKIRLFGLH VEGT_XENLA 65 65 -
GTEMIITKSGRRMFPTVKVSFTNVI TX12_CAEEL 94 94 -
GTEMIVTKTGRRMFPGYRIKISGLD BRC2_HALRO 157 157 -

Motif 2 width=14
Element Seqn Id St Int Rpt
YVHPESPNTGAHWM EOMD_XENLA 337 41 -
FIHPDSPAPGQKWM TBX6_BRARE 116 40 -
YIHPDSPATGEQWM TBX2_HUMAN 177 40 -
YIHPDSPATGEQWM TBX2_MOUSE 177 40 -
YIHPDSPNFGAHWM BRA2_BRAFL 117 40 -
YIHPDSPNFGAHWM BRA1_BRAFL 127 40 -
HYHPDSPAKGAQWM TBX1_MOUSE 76 42 -
MWHADGVRKGSDWM YNS6_CAEEL 173 40 -
LWHADGVRSGKEWM YNS2_CAEEL 202 40 -
FVHPQSPRSGEWWM CELZK3286 475 40 -
YIHPDSPATGAHWM TBX6_MOUSE 173 40 -
YIHPDSPTTGEQWM OMB_DROME 410 40 -
YMHPDSPNTGAHWM TBR1_HUMAN 287 41 -
YIHPDSPNFGAHWM BRAC_BRARE 117 40 -
YIHPDSPATGEQWM TBX3_MOUSE 73 39 -
YVHPDSPATGAHWM TBX5_HUMAN 133 40 -
VWHHNGSQTGKDWM YPX4_CAEEL 89 40 -
YAHPDCPLSPEALR H15_DROME 249 46 -
FLHPNSPANGSKWM BRC2_HALRO 222 40 -
YLHPDSPFTGDQLL TX12_CAEEL 161 42 -
YVHPDSPAPGAHWM VEGT_XENLA 130 40 -
YIHPDSPNFGAHWM BRAC_HEMPU 123 40 -
YVHPESPNFGAHWM BYN_DROME 169 40 -

Motif 3 width=10
Element Seqn Id St Int Rpt
VSFSKVKLTN BRA1_BRAFL 144 3 -
VTFHKLKLTN TBX3_MOUSE 90 3 -
VSFDKLKLTN TBX1_MOUSE 93 3 -
ICFDRVKISN YNS6_CAEEL 190 3 -
VCFDRVKITN YNS2_CAEEL 219 3 -
VDFKMAKLSN CELZK3286 492 3 -
VAFHKLKLTN TBX2_HUMAN 194 3 -
VAFHKLKLTN TBX2_MOUSE 194 3 -
VSFSKVKLTN BRA2_BRAFL 134 3 -
VSFQKLKLTN TBX5_HUMAN 150 3 -
VSFSKVKLSN BRAC_BRARE 134 3 -
ISFGKLKLTN TBR1_HUMAN 304 3 -
VSFHKLKLTN OMB_DROME 427 3 -
VSFHRVKLTN TBX6_MOUSE 190 3 -
ISFHKLKLTN TBX6_BRARE 133 3 -
ISFGKLKLTN EOMD_XENLA 354 3 -
ISFAKVKLTN BYN_DROME 186 3 -
VNFSKVKLSN BRAC_HEMPU 140 3 -
ICFQKLKLTN VEGT_XENLA 147 3 -
ISFEKTKLTN TX12_CAEEL 178 3 -
ISFHKVKLTN BRC2_HALRO 239 3 -
VSFEKVKLTN H15_DROME 266 3 -
VSFDQIRITN YPX4_CAEEL 106 3 -

Motif 4 width=15
Element Seqn Id St Int Rpt
ILHSMHKYQPRIHLV TBX6_MOUSE 209 9 -
ILNSMHRYQPRFHVV TBX1_MOUSE 112 9 -
YLNSMHKYIPVLTIY YNS6_CAEEL 210 10 -
FLHSMHKYTPVMSIY YNS2_CAEEL 239 10 -
VLNSMHRYNPRFHIV CELZK3286 511 9 -
ILNSMHKYQPRFHIV TBX3_MOUSE 109 9 -
HLLTQHRYIPVLTIY YPX4_CAEEL 128 12 -
VLNSMHRYQPRIHLV H15_DROME 285 9 -
VLNSMHRYQPRVHIV BRC2_HALRO 259 10 -
ILNSMHKYQPRIHIV TX12_CAEEL 197 9 -
ILHSMHRYKPRFHVV VEGT_XENLA 166 9 -
MLNSLHKYEPRIHII BRAC_HEMPU 158 8 -
MLNSLHKYEPRVHLV BYN_DROME 204 8 -
VLQSLHKYQPRLHIV EOMD_XENLA 376 12 -
VLHSMHKYQPRLHIV TBX6_BRARE 152 9 -
ILNSMHKYQPRFHIV TBX2_HUMAN 213 9 -
ILNSMHKYQPRFHIV TBX2_MOUSE 213 9 -
MLNSLHKYEPRIHIV BRA2_BRAFL 153 9 -
MLNSLHKYEPRLHII BRA1_BRAFL 162 8 -
ILNSMHKYQPRLHIV TBX5_HUMAN 169 9 -
MLNSLHKYEPRIHIV BRAC_BRARE 152 8 -
VLQSLHKYQPRLHVV TBR1_HUMAN 326 12 -
ILNSMHKYQPRFHLV OMB_DROME 449 12 -

Motif 5 width=14
Element Seqn Id St Int Rpt
AAFIAVTAYQNQEI TBX6_BRARE 188 21 -
TDFIAVTAYQNDKI TBX2_HUMAN 248 20 -
TDFIAVTAYQNDKI TBX2_MOUSE 248 20 -
TQFIAVTAYQNEEL BRA2_BRAFL 186 18 -
TQFIAVTAYQNEEI BRA1_BRAFL 195 18 -
TAFIAVTSYQNHKI TBX5_HUMAN 206 22 -
TQFIAVTAYQNEEI BRAC_BRARE 183 16 -
TQFIAVTAYQNTDI TBR1_HUMAN 364 23 -
TEFIAVTAYQNEKI OMB_DROME 484 20 -
TTFISVTAYQNPRI TBX6_MOUSE 244 20 -
NQFIAVTAYQNTDI EOMD_XENLA 414 23 -
TQFIAVTAYQNEEV BYN_DROME 235 16 -
TRFIAVTAYQNEDI BRAC_HEMPU 191 18 -
TEFTSVTAYQNEKI VEGT_XENLA 201 20 -
TQFMAVTAYQNQLI TX12_CAEEL 239 27 -
TVFITVTAYQNSEV BRC2_HALRO 294 20 -
TVFTAVTAYQNQLI H15_DROME 327 27 -
SQFISVTAYHKGEL YPX4_CAEEL 156 13 -
TEFIAVTAYQNDVV CELZK3286 546 20 -
TEFIAVTAYQNDAV YNS2_CAEEL 279 25 -
TEFIAVTAYQNQKI YNS6_CAEEL 250 25 -
TRFTAVTAYQNHRI TBX1_MOUSE 150 23 -
TEFIAVTAYQNDKI TBX3_MOUSE 144 20 -

Motif 6 width=9
Element Seqn Id St Int Rpt
NPFAKGFRD TBX2_MOUSE 269 7 -
NPYSTGSRK YPX4_CAEEL 177 7 -
NPFAKGFRD H15_DROME 348 7 -
NPFAKGFRE BRC2_HALRO 315 7 -
NPFAKGFRD TX12_CAEEL 260 7 -
NPFAKGFRE VEGT_XENLA 222 7 -
NPFAKAFLD BRAC_HEMPU 212 7 -
NPFAKAFLD BYN_DROME 256 7 -
NPFAKGFRD EOMD_XENLA 435 7 -
NPFAKGFRD TBX6_BRARE 209 7 -
NPFAKAFLD BRA2_BRAFL 207 7 -
NPFAKAFLD BRA1_BRAFL 216 7 -
NPFAKGLRD OMB_DROME 505 7 -
NPFAKGFRD TBR1_HUMAN 385 7 -
NPFAKGFRD TBX2_HUMAN 269 7 -
NPFAKGFRN CELZK3286 567 7 -
NPFAKGFRE YNS2_CAEEL 300 7 -
NSFAKGFRD YNS6_CAEEL 271 7 -
NPFAKGFRD TBX1_MOUSE 171 7 -
NPFAKGFRE TBX6_MOUSE 265 7 -
NPFAKGFRD TBX3_MOUSE 165 7 -
NPFAKAFLD BRAC_BRARE 204 7 -
NPFAKGFRG TBX5_HUMAN 227 7 -
Final Motifs
Motif 1  width=25
Element Seqn Id St Int Rpt
TNEMIVTKNGRRMFPVLKVNVSGLD BRAC_MOUSE 59 59 -
TNEMIVTKNGRRMFPVLKVNVSGLD O15178 59 59 -
TNEMIVTKNGRRMFPVLKVSMSGLD BRAC_XENLA 57 57 -
GTEMIITKAGRRMFPSYKVKVTGLN O73719 88 88 -
GTEMIITKAGRRMFPSYKVKVTGLN O43891 71 71 -
GTEMIITKAGRRMFPSYKVKVTGLN O15301 71 71 -
TNEMIVTKNGRRMFPVLKLNVSGLD O57386 61 61 -
TNEMIVTKNGRRMFPVLKVSVSGLD BRAC_CHICK 57 57 -
GTEMVITKSGRRMFPPFKVRVSGLD TBX2_HUMAN 112 112 -
GTEMVITKSGRRMFPPFKVRVSGLD TBX2_MOUSE 112 112 -
TNEMIVTKSGRRMFPVLKVNVSGLD BRA2_BRAFL 52 52 -
TNEMIVTKNGRRMFPVLKVNVSGLD BRA1_BRAFL 62 62 -
GTEMVITKSGRRMFPPFKVRCTGLD O73718 122 122 -
VTEMIITKAGRRMFPSYKVKVTGIN TBX5_HUMAN 68 68 -
GTEMIITKAGRRMFPSYKVKVTGMN O93288 74 74 -
TNEMIVTKTGRRMFPVLRASVSGLD O42100 52 52 -
TNEMIVTKTGRRMFPVLRASVTGLD BRAC_BRARE 52 52 -
TNEMIVTKNGRRMFPVLKISVSGLD TBXT_CHICK 56 56 -
QTEMIITKQGRRMFPFLSFNISGLD TBR1_MOUSE 221 221 -
QTEMIITKQGRRMFPFLSFNISGLD TBR1_HUMAN 221 221 -
GTEMVITKSGRQMFPQMKFRVSGLD OMB_DROME 345 345 -
GTEMIITKPGRRMFPHCKISLSGLV O93303 48 48 -
GTEMIITKPGRRMFPHCKISLSGLV O93389 48 48 -
GTEMIITKAGRRMFPACRVSVTGLD TBX6_MOUSE 108 108 -
GTEMIVTKAGRRMFPTFQVKLFGMD O43436 127 127 -
GTEMIVTKAGRRMFPTFQVKLFGMD O43435 127 127 -
GTEMVITKSGRRIFPAYRVKISGLD TBX2_CAEEL 78 78 -
GTEMLITKSGRRMFPSCKVTVTGLN TBX6_BRARE 51 51 -
QTEMIITKQGRRMFPFLSFNITGLN EOMD_XENLA 271 271 -
GTEMIITKTGRRMFPTFQVRIGGLD O62535 213 213 -
TNEMIVTKSGRRMFPVLKLTASGLE BRAC_HALRO 32 32 -
TNEMIVTKNGRRMFPVVKISASGLD BYN_DROME 104 104 -
GTEMIITKSGRRMFPQCKIRLFGLH O13161 65 65 -
GTEMIITKAGRRMFPAMRVKITGLD O70306 130 130 -
GTEMIITKAGRRMFPAMRVKITGLD O54840 87 87 -
TNEMIVTKSGRRMFPVLSASIAGLD BRAC_HEMPU 58 58 -
GTEMIVTKSGRRMFPTLSVIIAGLD O17212 48 48 -
GTEMIITKSGRRMFPQCKIRLFGLH VEGT_XENLA 65 65 -
GTEMIITKSGRRMFPTVKVSFTNVI TX12_CAEEL 94 94 -
GTEMIITKSGRRMFPTVKVSFTNVI O17276 94 94 -
GTEMIVTKTGRRMFPGYRIKISGLD BRC2_HALRO 157 157 -
GTEMIITKSGRRMFPTVRVSFSGPL H15_DROME 178 178 -
GTEMIITKKGRRMFPLVKLKLSGLD Q23467 410 410 -
KNEMIVTKSGRKMFPKLEYVVRGLT TBX8_CAEEL 137 137 -
VNEMIVTKNGRKLFPKLEYIVEGLD TBX9_CAEEL 108 108 -
DNEMVITVNGRRIFPTLEYTVTGLD YPX4_CAEEL 24 24 -

Motif 2 width=14
Element Seqn Id St Int Rpt
YIHPDSPNFGAHWM BRAC_MOUSE 124 40 -
YIHPDSPNFGAHWM O15178 124 40 -
YIHPDSPNFGAHWM BRAC_XENLA 122 40 -
YVHPDSPATGAHWM O73719 153 40 -
YVHPDSPATGAHWM O43891 136 40 -
YVHPDSPATGAHWM O15301 136 40 -
YIHPDSPNFGAHWM O57386 126 40 -
YIHPDSPNFGAHWM BRAC_CHICK 122 40 -
YIHPDSPATGEQWM TBX2_HUMAN 177 40 -
YIHPDSPATGEQWM TBX2_MOUSE 177 40 -
YIHPDSPNFGAHWM BRA2_BRAFL 117 40 -
YIHPDSPNFGAHWM BRA1_BRAFL 127 40 -
YIHPDSPATGEQWM O73718 187 40 -
YVHPDSPATGAHWM TBX5_HUMAN 133 40 -
YVHPDSPATGAHWM O93288 139 40 -
YIHPDSPNFGAHWM O42100 117 40 -
YIHPDSPNFGAHWM BRAC_BRARE 117 40 -
YIHPDSPNFGAHWM TBXT_CHICK 121 40 -
YMHPDSPNTGAHWM TBR1_MOUSE 287 41 -
YMHPDSPNTGAHWM TBR1_HUMAN 287 41 -
YIHPDSPTTGEQWM OMB_DROME 410 40 -
YLHPDSPAPGSHWM O93303 113 40 -
YLHPDSPAPGSHWM O93389 113 40 -
YIHPDSPATGAHWM TBX6_MOUSE 173 40 -
HYHPDSPAKGAQWM O43436 194 42 -
HYHPDSPAKGAQWM O43435 194 42 -
YIHPDSPSTGEHWM TBX2_CAEEL 143 40 -
FIHPDSPAPGQKWM TBX6_BRARE 116 40 -
YVHPESPNTGAHWM EOMD_XENLA 337 41 -
HVHPDSPAVGSNWM O62535 280 42 -
YVHPDSPNFGSHWM BRAC_HALRO 97 40 -
YVHPESPNFGAHWM BYN_DROME 169 40 -
YVHPDSPASGAHWM O13161 130 40 -
YIHPDSLASGDTWM O70306 197 42 -
YIHPDSLASGDTWM O54840 154 42 -
YIHPDSPNFGAHWM BRAC_HEMPU 123 40 -
FVHTDSPARGAHWM O17212 115 42 -
YVHPDSPAPGAHWM VEGT_XENLA 130 40 -
YLHPDSPFTGDQLL TX12_CAEEL 161 42 -
YLHPDSPFTGDQLL O17276 161 42 -
FLHPNSPANGSKWM BRC2_HALRO 222 40 -
YAHPDCPLSPEALR H15_DROME 249 46 -
FVHPQSPRSGEWWM Q23467 475 40 -
LWHADGVRSGKEWM TBX8_CAEEL 202 40 -
MWHADGVRKGSDWM TBX9_CAEEL 173 40 -
VWHHNGSQTGKDWM YPX4_CAEEL 89 40 -

Motif 3 width=10
Element Seqn Id St Int Rpt
VSFSKVKLTN BRAC_MOUSE 141 3 -
VSFSKVKLTN O15178 141 3 -
VSFSKVKLTN BRAC_XENLA 139 3 -
VSFQKLKLTN O73719 170 3 -
VSFQKLKLTN O43891 153 3 -
VSFQKLKLTN O15301 153 3 -
VSFSKVKLTN O57386 143 3 -
VSFSKVKLTN BRAC_CHICK 139 3 -
VAFHKLKLTN TBX2_HUMAN 194 3 -
VAFHKLKLTN TBX2_MOUSE 194 3 -
VSFSKVKLTN BRA2_BRAFL 134 3 -
VSFSKVKLTN BRA1_BRAFL 144 3 -
VTFHKLKLTN O73718 204 3 -
VSFQKLKLTN TBX5_HUMAN 150 3 -
VSFQKLKLTN O93288 156 3 -
VSFSKVKLSN O42100 134 3 -
VSFSKVKLSN BRAC_BRARE 134 3 -
ISFSKVKLTN TBXT_CHICK 138 3 -
ISFGKLKLTN TBR1_MOUSE 304 3 -
ISFGKLKLTN TBR1_HUMAN 304 3 -
VSFHKLKLTN OMB_DROME 427 3 -
VSFLKLKLTN O93303 130 3 -
VSFLKLKLTN O93389 130 3 -
VSFHRVKLTN TBX6_MOUSE 190 3 -
VSFDKLKLTN O43436 211 3 -
VSFDKLKLTN O43435 211 3 -
ANFHKLKLTN TBX2_CAEEL 160 3 -
ISFHKLKLTN TBX6_BRARE 133 3 -
ISFGKLKLTN EOMD_XENLA 354 3 -
VSFDKLKLTN O62535 297 3 -
VSFNKVKLTN BRAC_HALRO 114 3 -
ISFAKVKLTN BYN_DROME 186 3 -
ICFQKLKLTN O13161 147 3 -
VSFDKLKLTN O70306 214 3 -
VSFDKLKLTN O54840 171 3 -
VNFSKVKLSN BRAC_HEMPU 140 3 -
VSFDKMKLTN O17212 132 3 -
ICFQKLKLTN VEGT_XENLA 147 3 -
ISFEKTKLTN TX12_CAEEL 178 3 -
ISFEKTKLTN O17276 178 3 -
ISFHKVKLTN BRC2_HALRO 239 3 -
VSFEKVKLTN H15_DROME 266 3 -
VDFKMAKLSN Q23467 492 3 -
VCFDRVKITN TBX8_CAEEL 219 3 -
ICFDRVKISN TBX9_CAEEL 190 3 -
VSFDQIRITN YPX4_CAEEL 106 3 -

Motif 4 width=15
Element Seqn Id St Int Rpt
MLNSLHKYEPRIHIV BRAC_MOUSE 159 8 -
MLNSLHKYEPRIHIV O15178 159 8 -
MLNSLHKYEPRIHIV BRAC_XENLA 157 8 -
ILNSMHKYQPRLHIV O73719 189 9 -
ILNSMHKYQPRLHIV O43891 172 9 -
ILNSMHKYQPRLHIV O15301 172 9 -
MLNSLHKYEPRIHIV O57386 161 8 -
MLNSLHKYEPRIHIV BRAC_CHICK 157 8 -
ILNSMHKYQPRFHIV TBX2_HUMAN 213 9 -
ILNSMHKYQPRFHIV TBX2_MOUSE 213 9 -
MLNSLHKYEPRIHIV BRA2_BRAFL 153 9 -
MLNSLHKYEPRLHII BRA1_BRAFL 162 8 -
ILNSMHKYQPRFHIV O73718 223 9 -
ILNSMHKYQPRLHIV TBX5_HUMAN 169 9 -
ILNSMHKYQPRLHIV O93288 175 9 -
MLNSLHKYEPRIHIV O42100 152 8 -
MLNSLHKYEPRIHIV BRAC_BRARE 152 8 -
MLNSLHKYEPQVHIV TBXT_CHICK 156 8 -
VLQSLHKYQPRLHVV TBR1_MOUSE 326 12 -
VLQSLHKYQPRLHVV TBR1_HUMAN 326 12 -
ILNSMHKYQPRFHLV OMB_DROME 449 12 -
ILHSMHRYHPRFHIV O93303 149 9 -
ILHSMHRYHPRFHIV O93389 149 9 -
ILHSMHKYQPRIHLV TBX6_MOUSE 209 9 -
ILNSMHRYQPRFHVV O43436 230 9 -
ILNSMHRYQPRFHVV O43435 230 9 -
ILNSMHKYQPRLHVV TBX2_CAEEL 179 9 -
VLHSMHKYQPRLHIV TBX6_BRARE 152 9 -
VLQSLHKYQPRLHIV EOMD_XENLA 376 12 -
ILNSMHRYQPRFHLV O62535 316 9 -
MLNSLHKYEPRIHVV BRAC_HALRO 133 9 -
MLNSLHKYEPRVHLV BYN_DROME 204 8 -
ILHSMHRYKPRFHVV O13161 166 9 -
ILHSMHKYQPRVHVI O70306 233 9 -
ILHSMHKYQPRVHVI O54840 190 9 -
MLNSLHKYEPRIHII BRAC_HEMPU 158 8 -
IVNSMHKYRPRVHII O17212 151 9 -
ILHSMHRYKPRFHVV VEGT_XENLA 166 9 -
ILNSMHKYQPRIHIV TX12_CAEEL 197 9 -
ILNSMHKYQPRIHIV O17276 197 9 -
VLNSMHRYQPRVHIV BRC2_HALRO 259 10 -
VLNSMHRYQPRIHLV H15_DROME 285 9 -
VLNSMHRYNPRFHIV Q23467 511 9 -
FLHSMHKYTPVMSIY TBX8_CAEEL 239 10 -
YLNSMHKYIPVLTIY TBX9_CAEEL 210 10 -
HLLTQHRYIPVLTIY YPX4_CAEEL 128 12 -

Motif 5 width=14
Element Seqn Id St Int Rpt
TQFIAVTAYQNEEI BRAC_MOUSE 190 16 -
TQFIAVTAYQNEEI O15178 190 16 -
TQFIAVTAYQNEEI BRAC_XENLA 188 16 -
TAFIAVTSYQNHKI O73719 226 22 -
TAFIAVTSYQNHKI O43891 209 22 -
TAFIAVTSYQNHKI O15301 209 22 -
TQFIAVTAYQNEEI O57386 192 16 -
TQFTAVTAYQNEEI BRAC_CHICK 188 16 -
TDFIAVTAYQNDKI TBX2_HUMAN 248 20 -
TDFIAVTAYQNDKI TBX2_MOUSE 248 20 -
TQFIAVTAYQNEEL BRA2_BRAFL 186 18 -
TQFIAVTAYQNEEI BRA1_BRAFL 195 18 -
TEFIAVTAYQNDKI O73718 258 20 -
TAFIAVTSYQNHKI TBX5_HUMAN 206 22 -
TSFISVTSYQNHKI O93288 212 22 -
TQFIAVTAYQNEEI O42100 183 16 -
TQFIAVTAYQNEEI BRAC_BRARE 183 16 -
TQFIAVTAYQNEEI TBXT_CHICK 187 16 -
TQFIAVTAYQNTDI TBR1_MOUSE 364 23 -
TQFIAVTAYQNTDI TBR1_HUMAN 364 23 -
TEFIAVTAYQNEKI OMB_DROME 484 20 -
TSFTAVTAYQNTKI O93303 184 20 -
TSFTAVTAYQNTKI O93389 184 20 -
TTFISVTAYQNPRI TBX6_MOUSE 244 20 -
TRFTAVTAYQNHRI O43436 268 23 -
TRFTAVTAYQNHRI O43435 268 23 -
TEFIAVTAYQNEKV TBX2_CAEEL 214 20 -
AAFIAVTAYQNQEI TBX6_BRARE 188 21 -
NQFIAVTAYQNTDI EOMD_XENLA 414 23 -
TSFTAVTAYQNQRV O62535 356 25 -
SQFIAVTAYQNEEV BRAC_HALRO 167 19 -
TQFIAVTAYQNEEV BYN_DROME 235 16 -
TEFTAVTAYQNEKI O13161 201 20 -
TVFTTVTAYQNQQI O70306 275 27 -
TVFTTVTAYQNQQI O54840 232 27 -
TRFIAVTAYQNEDI BRAC_HEMPU 191 18 -
TEFIAVTAYQNHRI O17212 181 15 -
TEFTSVTAYQNEKI VEGT_XENLA 201 20 -
TQFMAVTAYQNQLI TX12_CAEEL 239 27 -
TQFMAVTAYQNQLI O17276 239 27 -
TVFITVTAYQNSEV BRC2_HALRO 294 20 -
TVFTAVTAYQNQLI H15_DROME 327 27 -
TEFIAVTAYQNDVV Q23467 546 20 -
TEFIAVTAYQNDAV TBX8_CAEEL 279 25 -
TEFIAVTAYQNQKI TBX9_CAEEL 250 25 -
SQFISVTAYHKGEL YPX4_CAEEL 156 13 -

Motif 6 width=9
Element Seqn Id St Int Rpt
NPFAKAFLD BRAC_MOUSE 211 7 -
NPFAKAFLD O15178 211 7 -
NPFAKAFLD BRAC_XENLA 209 7 -
NPFAKGFRG O73719 247 7 -
NPFAKGFRG O43891 230 7 -
NPFAKGFRG O15301 230 7 -
NPFAKAFLD O57386 213 7 -
NPFAKAFLD BRAC_CHICK 209 7 -
NPFAKGFRD TBX2_HUMAN 269 7 -
NPFAKGFRD TBX2_MOUSE 269 7 -
NPFAKAFLD BRA2_BRAFL 207 7 -
NPFAKAFLD BRA1_BRAFL 216 7 -
NPFAKGFRD O73718 279 7 -
NPFAKGFRG TBX5_HUMAN 227 7 -
NPFAKGFRG O93288 233 7 -
NPFAKAFLD O42100 204 7 -
NPFAKAFLD BRAC_BRARE 204 7 -
NPFAKAFLD TBXT_CHICK 208 7 -
NPFAKGFRD TBR1_MOUSE 385 7 -
NPFAKGFRD TBR1_HUMAN 385 7 -
NPFAKGLRD OMB_DROME 505 7 -
NPFAKGFRD O93303 205 7 -
NPFAKGFRD O93389 205 7 -
NPFAKGFRE TBX6_MOUSE 265 7 -
NPFAKGFRD O43436 289 7 -
NPFAKGFRD O43435 289 7 -
NPFAKGFRD TBX2_CAEEL 235 7 -
NPFAKGFRD TBX6_BRARE 209 7 -
NPFAKGFRD EOMD_XENLA 435 7 -
NPFAKGFRD O62535 377 7 -
NPFAKAFLD BRAC_HALRO 188 7 -
NPFAKAFLD BYN_DROME 256 7 -
NPFAKGFRE O13161 222 7 -
NPFAKGFRD O70306 296 7 -
NPFAKGFRD O54840 253 7 -
NPFAKAFLD BRAC_HEMPU 212 7 -
NPFAKGFRE O17212 202 7 -
NPFAKGFRE VEGT_XENLA 222 7 -
NPFAKGFRD TX12_CAEEL 260 7 -
NPFAKGFRD O17276 260 7 -
NPFAKGFRE BRC2_HALRO 315 7 -
NPFAKGFRD H15_DROME 348 7 -
NPFAKGFRN Q23467 567 7 -
NPFAKGFRE TBX8_CAEEL 300 7 -
NSFAKGFRD TBX9_CAEEL 271 7 -
NPYSTGSRK YPX4_CAEEL 177 7 -