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PR00928

Identifier
GRAVESDC  [View Relations]  [View Alignment]  
Accession
PR00928
No. of Motifs
6
Creation Date
15-AUG-1998  (UPDATE 10-JUN-1999)
Title
Graves disease carrier protein signature
Database References
PRINTS; PR00926 MITOCARRIER
PROSITE; PS00215 MITOCH_CARRIER
BLOCKS; BL00215
INTERPRO; IPR002167
Literature References
1. ZARRILLI, R., OATES, E.L., MCBRIDE, O.W., LERMAN, M.I., CHAN, J.Y.,
SANTISTEBAN, P., URSINI, M.V., NOTKINS, A.L. AND KOHN, L.D.
Sequence and chromosomal assignment of a novel cDNA identified by 
immunoscreening of a thyroid expression library: similarity to a family
of mitochondrial solute carrier proteins. 
MOL.ENDOCRINOL. 3 1498-1505 (1989). 
 
2. FIERMONTE, G., RUNSWICK, M.J., WALKER, J.E. AND PALMIERI, F.
Sequence and pattern of expression of a bovine homologue of a human 
mitochondrial transport protein associated with Grave's disease. 
DNA SEQ. 3 71-78(1992).

Documentation
Graves disease carrier protein (GDC) is a protein of as yet uncharacterised
function that belongs to the mitochondrial metabolite carrier family 
(which includes the ADP/ATP translocator, the phosphate carrier and the
hydrogen ion uncoupling protein) [1,2]. The protein is recognised by IgG 
from patients with active Graves disease.
 
GDC is an integral membrane protein thought to reside in the inner
mitochondrial membrane. The predicted amino acid sequence of 348 residues 
comprises three similar domains.
 
GRAVESDC is a 6-element fingerprint that provides a signature for Graves
disease carrier proteins. The fingerprint was derived from an initial
alignment of 4 sequences: the motifs were drawn from short conserved 
regions spanning the full alignment length - motifs 1-3 span the N-terminal
domain; motif 4 lies in the central domain; and motifs 5 and 6 span the
C-terminal domain. A single iteration on OWL30.2 was required to reach
convergence, no further sequences being identified beyond the starting set.
A single partial match was found, YHG2_YEAST, a putative mitochondrial 
carrier protein from S.cerevisiae.
 
An update on SPTR37_9f identified a true set of 2 sequences, and 1
partial match.
Summary Information
   2 codes involving  6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
6222222
5000000
4000000
3000000
2110000
123456
True Positives
GDC_BOVIN     GDC_HUMAN     
True Positive Partials
Codes involving 2 elements
YHG2_YEAST
Sequence Titles
GDC_BOVIN   GRAVE'S DISEASE CARRIER PROTEIN (GDC) (MITOCHONDRIAL SOLUTE CARRIER PROTEIN HOMOLOG) - BOS TAURUS (BOVINE). 
GDC_HUMAN GRAVE'S DISEASE CARRIER PROTEIN (GDC) (MITOCHONDRIAL SOLUTE CARRIER PROTEIN HOMOLOG) - HOMO SAPIENS (HUMAN).

YHG2_YEAST PUTATIVE MITOCHONDRIAL CARRIER YHR002W - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Scan History
OWL30_2    1  50   NSINGLE    
SPTR37_9f 2 4 NSINGLE
Initial Motifs
Motif 1  width=21
Element Seqn Id St Int Rpt
RRDFYWLRSFLAGSIAGCCAK GDC_RAT 31 31 -
RRDFYWLRSFLAGSIAGCCAK HUMMSCA 31 31 -
RRDFYWLRSFLAGGIAGCCAK GDC_BOVIN 29 29 -
RRDFYWLRSFLAGSIAGCCAK GDC_HUMAN 31 31 -

Motif 2 width=21
Element Seqn Id St Int Rpt
PLDRVKVLLQAHNHHYKHLGV HUMMSCA 56 4 -
PLDRVKVLLQAHNHHYRHLGV GDC_BOVIN 54 4 -
PLDRVKVLLQAHNHHYKHLGV GDC_HUMAN 56 4 -
PLDRVKVLLQAHNHHYKHLGV GDC_RAT 56 4 -

Motif 3 width=25
Element Seqn Id St Int Rpt
FEHYKTFITTKLGVSGHVHRLMAGS GDC_RAT 114 37 -
FEHYKTLITTKLGISGHVHRLMAGS HUMMSCA 114 37 -
FEHYKTLITTKLGISGHVHRLMAGS GDC_HUMAN 114 37 -
FEHYKTLITTKLGVSGHVHRLMAGS GDC_BOVIN 112 37 -

Motif 4 width=22
Element Seqn Id St Int Rpt
YTGIIHAFKTIYAKEGGFFGFY HUMMSCA 168 29 -
YTGIIHAFKTIYAKEGGFLGFY GDC_BOVIN 166 29 -
YTGIIHAFKTIYAKEGGFFGFY GDC_HUMAN 168 29 -
YSGIIHAFKTIYAKEGGFLGFY GDC_RAT 171 32 -

Motif 5 width=20
Element Seqn Id St Int Rpt
VLVLKTHINLLCGGVAGAIA GDC_BOVIN 233 45 -
VLVLKTHVNLLCGGVARAIA HUMMSCA 235 45 -
VLVLKTHVNLLCGGVARAIA GDC_HUMAN 235 45 -
VLVLKTHINLLCGGVARAIA GDC_RAT 238 45 -

Motif 6 width=21
Element Seqn Id St Int Rpt
YGHHGIRKGLYRGLSLNYIRC GDC_BOVIN 289 36 -
YGHHGIRRGLYRGLSLNYIRC GDC_RAT 294 36 -
YGHHGIRKGLYRGLSLNYIRC GDC_HUMAN 291 36 -
YGHHGIRKGLYRGLSLNYIRC HUMMSCA 291 36 -
Final Motifs
Motif 1  width=21
Element Seqn Id St Int Rpt
RRDFYWLRSFLAGGIAGCCAK GDC_BOVIN 29 29 -
RRDFYWLRSFLAGSIAGCCAK GDC_HUMAN 31 31 -

Motif 2 width=21
Element Seqn Id St Int Rpt
PLDRVKVLLQAHNHHYRHLGV GDC_BOVIN 54 4 -
PLDRVKVLLQAHNHHYKHLGV GDC_HUMAN 56 4 -

Motif 3 width=25
Element Seqn Id St Int Rpt
FEHYKTLITTKLGVSGHVHRLMAGS GDC_BOVIN 112 37 -
FEHYKTLITTKLGISGHVHRLMAGS GDC_HUMAN 114 37 -

Motif 4 width=22
Element Seqn Id St Int Rpt
YTGIIHAFKTIYAKEGGFLGFY GDC_BOVIN 166 29 -
YTGIIHAFKTIYAKEGGFFGFY GDC_HUMAN 168 29 -

Motif 5 width=20
Element Seqn Id St Int Rpt
VLVLKTHINLLCGGVAGAIA GDC_BOVIN 233 45 -
VLVLKTHVNLLCGGVARAIA GDC_HUMAN 235 45 -

Motif 6 width=21
Element Seqn Id St Int Rpt
YGHHGIRKGLYRGLSLNYIRC GDC_BOVIN 289 36 -
YGHHGIRKGLYRGLSLNYIRC GDC_HUMAN 291 36 -