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PR00896

Identifier
VASOPRESSINR  [View Relations]  [View Alignment]  
Accession
PR00896
No. of Motifs
8
Creation Date
16-APR-1998  (UPDATE 10-JUN-1999)
Title
Vasopressin receptor signature
Database References
PRINTS; PR90007 7TM; PR90006 GPCRCLAN; PR00237 GPCRRHODOPSN
PRINTS; PR00665 OXYTOCINR; PR00752 VASOPRSNV1AR; PR00897 VASOPRSNV1BR
PRINTS; PR00898 VASOPRSNV2R
INTERPRO; IPR001817
GCRDB; GCR_0360; GCR_0942; GCR_0364; GCR_0798; GCR_0383; GCR_0026

GCRDB; GCR_0033
Literature References
1. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
 
2. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
G protein-coupled receptor fingerprints.
7TM, VOLUME 2, EDS. G.VRIEND AND B.BYWATER (1993).
 
3. BIRNBAUMER, L.
G proteins in signal transduction.
ANNU.REV.PHARMACOL.TOXICOL. 30 675-705 (1990).
 
4. CASEY, P.J. AND GILMAN, A.G.
G protein involvement in receptor-effector coupling.
J.BIOL.CHEM. 263(6) 2577-2580 (1988).
 
5. ATTWOOD, T.K. AND FINDLAY, J.B.C. 
Design of a discriminating fingerprint for G protein-coupled receptors.
PROTEIN ENG. 6(2) 167-176 (1993).
 
6. WATSON, S. AND ARKINSTALL, S.
Vasopressin and oxytocin.
IN THE G PROTEIN-LINKED RECEPTOR FACTSBOOK, ACADEMIC PRESS, 1994, PP.284-291.

Documentation
G protein-coupled receptors (GPCRs) constitute a vast protein family that 
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the 
sequence level, on the basis of which they can be separated into distinct 
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship, 
but between which there is no statistically significant similarity in 
sequence [1]. The currently known clan members include the rhodopsin-like 
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
 
The rhodopsin-like GPCRs themselves represent a widespread protein family 
that includes hormone, neurotransmitter and light receptors, all of
which transduce extracellular signals through interaction with guanine
nucleotide-binding (G) proteins. Although their activating ligands vary 
widely in structure and character, the amino acid sequences of the 
receptors are very similar and are believed to adopt a common structural 
framework comprising 7 transmembrane (TM) helices [3-5]. 
 
Vasopressin and oxytocin are members of the neurohypophyseal hormone family
found in all mammalian species [6]. They are present in high levels in the
posterior pituitary. Vasopressin has an essential role in the control of 
the water content of the body, acting in the kidney to increase water and
sodium absorption [6]. In higher concentrations, vasopressin stimulates
contraction of vascular smooth muscle, stimulates glycogen breakdown in the
liver, induces platelet activation, and evokes release of corticotrophin 
from the anterior pituitary [6]. Vasopressin and its analogues are used
clinically to treat diabetes insipidus [6]. Oxytocin stimulates contraction 
of uterine smooth muscle, and stimulates milk secretion in response to 
suckling by inducing contraction of myoepithelial cells in the mammary gland
[6]. Clinically, it is used to induce labour and promote lactation.
 
VASOPRESSINR is an 8-element fingerprint that provides a signature for the
vasopressin receptor family. The fingerprint was derived from an initial
alignment of 19 sequences: the motifs were drawn from conserved sections
spanning the full alignment length, focusing on those regions that
characterise the vasopressin family of receptors but distinguish them from
the rest of the rhodopsin-like GPCRs - motif 1 lies at the N-terminus,
leading into the first TM domain; motif 2 spans the C-terminus of the first
cytoplasmic loop, leading into TM domain 2; motif 3 lies in the first
external loop; motif 4 lies in the second external loop; motif 5 lies at 
the C-terminus of TM domain 5, leading into the third cytoplasmic loop; 
motif 6 lies at the C-terminus of the third cytoplasmic loop, leading into
TM domain 6; motif 7 lies in the third external loop; and motif 8 resides
at the C-terminus of TM domain 7. Two iterations on OWL30.1 were required
to reach convergence, at which point a true set comprising 25 sequences was
identified. Several partial matches were also found, all of which are
fragments, or closely related rhodopsin-like GPCRs that fail to match one
or more motifs.
 
An update on SPTR37_9f identified a true set of 24 sequences, and 2
partial matches.
Summary Information
  24 codes involving  8 elements
1 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
82424242424242424
711111110
600000000
500000000
400000000
300000000
211000000
12345678
True Positives
O77808        O88721        OXYR_BOVIN    OXYR_HUMAN    
OXYR_MACMU OXYR_MOUSE OXYR_PIG OXYR_RAT
OXYR_SHEEP Q25396 Q25397 Q90252
Q90334 Q90352 V1AR_HUMAN V1AR_MOUSE
V1AR_RAT V1AR_SHEEP V1BR_HUMAN V1BR_RAT
V2R_BOVIN V2R_HUMAN V2R_PIG V2R_RAT
True Positive Partials
Codes involving 7 elements
O43192
Codes involving 2 elements
O70501
Sequence Titles
O77808      VASOPRESSIN V2 RECEPTOR - CANIS FAMILIARIS (DOG). 
O88721 VASOPRESSIN RECEPTOR TYPE II - MUS MUSCULUS (MOUSE).
OXYR_BOVIN Oxytocin receptor (OT-R) - Bos taurus (Bovine).
OXYR_HUMAN Oxytocin receptor (OT-R) - Homo sapiens (Human).
OXYR_MACMU Oxytocin receptor (OT-R) - Macaca mulatta (Rhesus macaque).
OXYR_MOUSE Oxytocin receptor (OT-R) - Mus musculus (Mouse).
OXYR_PIG Oxytocin receptor (OT-R) - Sus scrofa (Pig).
OXYR_RAT Oxytocin receptor (OT-R) - Rattus norvegicus (Rat).
OXYR_SHEEP Oxytocin receptor (OT-R) - Ovis aries (Sheep).
Q25396 CONOPRESSIN RECEPTOR - LYMNAEA STAGNALIS (GREAT POND SNAIL).
Q25397 CONOPRESSIN RECEPTOR 2 - LYMNAEA STAGNALIS (GREAT POND SNAIL).
Q90252 MESOTOCIN RECEPTOR (MTR) - BUFO MARINUS (GIANT TOAD) (CANE TOAD).
Q90334 ISOTOCIN RECEPTOR - CATOSTOMUS COMMERSONI (WHITE SUCKER).
Q90352 VASOSTOCIN-RECEPTOR - CATOSTOMUS COMMERSONI (WHITE SUCKER).
V1AR_HUMAN Vasopressin V1a receptor (V1aR) (Vascular/hepatic-type arginine vasopressin receptor) (Antidiuretic hormone receptor 1a) (AVPR V1a) - Homo sapiens (Human).
V1AR_MOUSE Vasopressin V1a receptor (V1aR) (Vascular/hepatic-type arginine vasopressin receptor) (Antidiuretic hormone receptor 1a) (AVPR V1a) - Mus musculus (Mouse).
V1AR_RAT Vasopressin V1a receptor (V1aR) (Vascular/hepatic-type arginine vasopressin receptor) (Antidiuretic hormone receptor 1a) (AVPR V1a) - Rattus norvegicus (Rat).
V1AR_SHEEP Vasopressin V1a receptor (V1aR) (Vascular/hepatic-type arginine vasopressin receptor) (Antidiuretic hormone receptor 1a) (AVPR V1a) - Ovis aries (Sheep).
V1BR_HUMAN Vasopressin V1b receptor (V1bR) (AVPR V1b) (Vasopressin V3 receptor) (AVPR V3) (Antidiuretic hormone receptor 1b) - Homo sapiens (Human).
V1BR_RAT Vasopressin V1b receptor (V1bR) (AVPR V1b) (Vasopressin V3 receptor) (AVPR V3) (Antidiuretic hormone receptor 1b) - Rattus norvegicus (Rat).
V2R_BOVIN Vasopressin V2 receptor (Renal-type arginine vasopressin receptor) (Antidiuretic hormone receptor) (AVPR V2) - Bos taurus (Bovine).
V2R_HUMAN Vasopressin V2 receptor (Renal-type arginine vasopressin receptor) (Antidiuretic hormone receptor) (AVPR V2) - Homo sapiens (Human).
V2R_PIG Vasopressin V2 receptor (Renal-type arginine vasopressin receptor) (Antidiuretic hormone receptor) (AVPR V2) - Sus scrofa (Pig).
V2R_RAT Vasopressin V2 receptor (Renal-type arginine vasopressin receptor) (Antidiuretic hormone receptor) (AVPR V2) - Rattus norvegicus (Rat).

O43192 VASOPRESSIN RECEPTOR TYPE 2 - HOMO SAPIENS (HUMAN).

O70501 VASOPRESSIN V1B RECEPTOR VARIANT - RATTUS NORVEGICUS (RAT).
Scan History
OWL30_1    2  600  NSINGLE    
SPTR37_9f 2 38 NSINGLE
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
RDPLLAQAELALL V2R_BOVIN 32 32 -
RDEELAKVEIGIL V1BR_RAT 29 29 -
RDEELAKVEIGVL V1BR_HUMAN 29 29 -
RNEELAKLEIAVL V1AR_SHEEP 45 45 -
RNEELAKLEIAVL V1AR_HUMAN 46 46 -
RNEELAKLEIAVL V1AR_RAT 46 46 -
RNEALARVEVAVL OXYR_PIG 34 34 -
RNEALARVEVAVL OXYR_HUMAN 34 34 -
RNEALARVEVAVL D86599 34 34 -
RNEELAKLEVTVL MUSV1AAVRA 46 46 -
RNEELAKLEFTVL MUSV1AAVRB 46 46 -
RNEELAKLEIAVL S71837 46 46 -
RDEELAKVEIGIL RNU27322 29 29 -
RNEEVAKMEITVL I50132 19 19 -
RDESLARIEILVQ LSU40491 45 45 -
VDEDLLKIEIAVQ LSU27464 65 65 -
RDPLLARAELALL V2R_HUMAN 32 32 -
RDPLLVRAELALL V2R_RAT 32 32 -
RDPLLARVELALL V2R_PIG 31 31 -

Motif 2 width=12
Element Seqn Id St Int Rpt
KTSRMHLFIRHL V1AR_SHEEP 81 23 -
KTSRMHLFIRHL V1AR_HUMAN 82 23 -
KTSRMHLFIRHL V1AR_RAT 82 23 -
KHSRLFFFMKHL OXYR_PIG 70 23 -
KHSRLFFFMKHL OXYR_HUMAN 70 23 -
HWAPIHVFIGHL V2R_HUMAN 70 25 -
RWAPMHVFISHL V2R_RAT 70 25 -
RWAPMHVFIGHL V2R_BOVIN 70 25 -
KTSRMHLFIRHL S71837 82 23 -
KHSRLFFFMKHL D86599 70 23 -
KTSRMHLFIRHL MUSV1AAVRA 82 23 -
KTSRMHLFIRHL MUSV1AAVRB 82 23 -
KPSRMHLFVLHL RNU27322 65 23 -
KSSRMHLFIKHL I50132 55 23 -
AASRMHLFIFHL LSU40491 81 23 -
KLTRMQWFIAHL LSU27464 101 23 -
RWAPMHVFIGHL V2R_PIG 69 25 -
KRSRMHLFVLHL V1BR_RAT 65 23 -
KRSRMHLFVLHL V1BR_HUMAN 65 23 -

Motif 3 width=15
Element Seqn Id St Int Rpt
PQLCWDITYRFRGPD MUSV1AAVRB 107 13 -
PQLCWDITSSFRGPD S71837 107 13 -
PQLLWDITFRFYGPD D86599 95 13 -
PQLCWDITYRFRGPD MUSV1AAVRA 107 13 -
PQLLWDITYRFQGSD RNU27322 90 13 -
PQLCWEITFRFYGPD I50132 80 13 -
PQLIWDITERFYGGD LSU40491 106 13 -
PQLISDVTIVFHGDD LSU27464 126 13 -
PQLLWDITFRFYGPD OXYR_HUMAN 95 13 -
PQLLWDITFRFYGPD OXYR_PIG 95 13 -
PQLCWDITYRFRGPD V1AR_RAT 107 13 -
PQMCWDITYRFRGPD V1AR_HUMAN 107 13 -
PQLGWDITYRFRGPD V1AR_SHEEP 106 13 -
PQLLWDITYRFQGPD V1BR_HUMAN 90 13 -
PQLLWDITYRFQGSD V1BR_RAT 90 13 -
PQLAWDATYRFRGPD V2R_PIG 94 13 -
PQLAWDATDRFRGPD V2R_BOVIN 95 13 -
PQLAWDATDRFHGPD V2R_RAT 95 13 -
PQLAWKATDRFRGPD V2R_HUMAN 95 13 -

Motif 4 width=15
Element Seqn Id St Int Rpt
DCWADFGFPWGPRAY V1BR_HUMAN 185 80 -
DCWANFIHPWGLPAY V1AR_SHEEP 201 80 -
DCWAVFIQPWGPKAY OXYR_HUMAN 186 76 -
DCWAVFIQPWGPKAY OXYR_PIG 186 76 -
DCWATFIQPWGTRAY V1AR_RAT 204 82 -
DCWATFIQPWGSRAY V1AR_HUMAN 202 80 -
DCLATFEPDWGMQAY LSU27464 219 78 -
ECWGRFEPPWTLNLY LSU40491 202 81 -
DCWGHFIEPWGIRAY I50132 175 80 -
DCWADFYFSWGPRAY RNU27322 185 80 -
DCWATFIPPWGTRAY MUSV1AAVRB 204 82 -
DCWATFIPPWGTRAY MUSV1AAVRA 204 82 -
DCWAVFIQPWGPKAY D86599 186 76 -
DCWATFIQPWGTRAY S71837 204 82 -
DCWACFAEPWGRRTY V2R_HUMAN 191 81 -
DCWARFAEPWGLRAY V2R_RAT 191 81 -
DCWARFAEPWGLRAY V2R_BOVIN 190 80 -
DCWASFAEPWGLRAY V2R_PIG 190 81 -
DCWADFYFSWGPRAY V1BR_RAT 185 80 -

Motif 5 width=13
Element Seqn Id St Int Rpt
CYGLISFKIWQNL D86599 219 18 -
CYGFICYHIWRNI S71837 237 18 -
CYGFICYNIWCNV V1AR_HUMAN 235 18 -
CYGFICYHIWRNI V1AR_RAT 237 18 -
CYGLISFKIWQNL OXYR_PIG 219 18 -
CYGLISFKIWQNL OXYR_HUMAN 219 18 -
CYSLICHEICKNL V1BR_HUMAN 218 18 -
CQVLIFREIHASL V2R_HUMAN 224 18 -
CQVLIFREIHASL V2R_RAT 224 18 -
CQVLIFREIHASL V2R_BOVIN 223 18 -
CQVLIFREIHTSL V2R_PIG 223 18 -
CYGFICYHIWRKV V1AR_SHEEP 234 18 -
CYGLICHEIYKNL V1BR_RAT 218 18 -
CYGRICHVVWMSV LSU27464 252 18 -
AYVSICCTIWRKY LSU40491 235 18 -
CYGFICHSIWKNI I50132 208 18 -
CYGLICHEIYKNL RNU27322 218 18 -
CYGFICYHIWRNV MUSV1AAVRB 237 18 -
CYGFICYHIWRNV MUSV1AAVRA 237 18 -

Motif 6 width=15
Element Seqn Id St Int Rpt
ISKAKIRTVKMTFII D86599 265 33 -
ISRAKLRTVKMTLVI I50132 247 26 -
ISRAKIRTVKMTFVI RNU27322 269 38 -
ISRAKIRTVKMTFVI MUSV1AAVRB 287 37 -
ISRAKIRTVKMTFVI MUSV1AAVRA 287 37 -
ISRAKIRTVKMTFVI S71837 288 38 -
ISKAKIRTVKMTFII OXYR_HUMAN 266 34 -
ISKAKIRTVKMTFII OXYR_PIG 268 36 -
ISRAKIRTVKMTFVI V1AR_RAT 288 38 -
ISRAKIRTVKMTFVI V1AR_HUMAN 282 34 -
ISRAKIRTVKMTFVI V1AR_SHEEP 282 35 -
ISRAKIRTVKMTFVI V1BR_HUMAN 272 41 -
ISRAKIRTVKMTFVI V1BR_RAT 273 42 -
VSAAMAKTARMTLVI V2R_PIG 261 25 -
VSAAVAKTVKMTLVI V2R_BOVIN 261 25 -
VSAAMAKTVRMTLVI V2R_RAT 262 25 -
VSAAVAKTVRMTLVI V2R_HUMAN 262 25 -
FSRAKLKTVKLTFVV LSU40491 313 65 -
VSKSKMKTIKLTLTV LSU27464 329 64 -

Motif 7 width=8
Element Seqn Id St Int Rpt
IQMWSVWD V1AR_HUMAN 310 13 -
IQMWSAWD V1AR_SHEEP 310 13 -
VQMWSVWD V1BR_HUMAN 300 13 -
VQMWSVWD V1BR_RAT 301 13 -
VQLWSVWD V2R_PIG 289 13 -
VQLWAAWD V2R_BOVIN 289 13 -
VQLWAAWD V2R_HUMAN 290 13 -
VQMWSAFD LSU27464 357 13 -
VQLWAAWD V2R_RAT 290 13 -
VQMWSVWD S71837 316 13 -
VQMWSVWD D86599 293 13 -
VQMWSVWD MUSV1AAVRA 315 13 -
VQMWSVWD MUSV1AAVRB 315 13 -
VQMWSVWD RNU27322 297 13 -
VQMWSVWD I50132 275 13 -
SQLWWLYD LSU40491 341 13 -
VQMWSVWD OXYR_HUMAN 294 13 -
VQMWSVWD OXYR_PIG 296 13 -
VQMWSVWD V1AR_RAT 316 13 -

Motif 8 width=9
Element Seqn Id St Int Rpt
LLASLNSCT LSU27464 379 14 -
LLASLNSCC I50132 300 17 -
LLGNLSSCC RNU27322 322 17 -
LLASLNSCC MUSV1AAVRB 340 17 -
LLASLNSCC MUSV1AAVRA 340 17 -
LLASLNSCC S71837 341 17 -
LLASLNSCT V2R_HUMAN 312 14 -
LLASLNSCT V2R_RAT 312 14 -
LLASLNSCT V2R_BOVIN 311 14 -
LLASLNSCT V2R_PIG 311 14 -
LLGNLSSCC V1BR_RAT 326 17 -
LLGNLNSCC V1BR_HUMAN 325 17 -
LLASLNSCC V1AR_SHEEP 335 17 -
LLGSLNSCC V1AR_HUMAN 335 17 -
LLASLNSCC V1AR_RAT 341 17 -
LLASLNSCC OXYR_PIG 318 14 -
LLASLNSCC OXYR_HUMAN 316 14 -
LLASLNSCC D86599 315 14 -
LLASLNSCC LSU40491 362 13 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
RNEALARVEVAVL OXYR_HUMAN 34 34 -
RNEALARVEVAVL OXYR_MACMU 34 34 -
RNEALARVEVAVL OXYR_MOUSE 34 34 -
RNEALARVEVAVL OXYR_PIG 34 34 -
RNEALARVEVAVL OXYR_RAT 34 34 -
RNEALARVEVAVL OXYR_BOVIN 34 34 -
RNEALARVEVAVL OXYR_SHEEP 34 34 -
RNEELAKLEVTVL V1AR_MOUSE 46 46 -
RNEELAKLEIAVL V1AR_RAT 46 46 -
RNEEVAKVEVTVL Q90252 39 39 -
RNEELAKLEIAVL V1AR_HUMAN 46 46 -
RNEELAKLEIAVL V1AR_SHEEP 45 45 -
RNEEVAKMEITVL Q90352 19 19 -
RDEELAKVEIGVL V1BR_HUMAN 29 29 -
RNEEVAKVEVTVL Q90334 38 38 -
RDEELAKVEIGIL V1BR_RAT 29 29 -
RDPLLARVELALL V2R_PIG 31 31 -
RDPLLAQAELALL V2R_BOVIN 32 32 -
RDPLLVRAELALL O88721 32 32 -
RDPLLVRAELALL V2R_RAT 32 32 -
RDPLLVQAELALL O77808 31 31 -
RDPLLARAELALL V2R_HUMAN 32 32 -
RDESLARIEILVQ Q25397 45 45 -
VDEDLLKIEIAVQ Q25396 65 65 -

Motif 2 width=12
Element Seqn Id St Int Rpt
KHSRLFFFMKHL OXYR_HUMAN 70 23 -
KHSRLFFFMKHL OXYR_MACMU 70 23 -
KHSRLFFFMKHL OXYR_MOUSE 70 23 -
KHSRLFFFMKHL OXYR_PIG 70 23 -
KHSRLFFFMKHL OXYR_RAT 70 23 -
KHSRLFFFMKHL OXYR_BOVIN 70 23 -
KHSRLFFFMKHL OXYR_SHEEP 70 23 -
KTSRMHLFIRHL V1AR_MOUSE 82 23 -
KTSRMHLFIRHL V1AR_RAT 82 23 -
KHSRMYFFMKHL Q90252 75 23 -
KTSRMHLFIRHL V1AR_HUMAN 82 23 -
KTSRMHLFIRHL V1AR_SHEEP 81 23 -
KSSRMHLFIKHL Q90352 55 23 -
KRSRMHLFVLHL V1BR_HUMAN 65 23 -
TQSRMYYLMKHL Q90334 74 23 -
KRSRMHLFVLHL V1BR_RAT 65 23 -
RWAPMHVFIGHL V2R_PIG 69 25 -
RWAPMHVFIGHL V2R_BOVIN 70 25 -
RWAPMHVFISHL O88721 70 25 -
RWAPMHVFISHL V2R_RAT 70 25 -
RWAPMHVFIGHL O77808 69 25 -
HWAPIHVFIGHL V2R_HUMAN 70 25 -
AASRMHLFIFHL Q25397 81 23 -
KLTRMQWFIAHL Q25396 101 23 -

Motif 3 width=15
Element Seqn Id St Int Rpt
PQLLWDITFRFYGPD OXYR_HUMAN 95 13 -
PQLLWDITFRFYGPD OXYR_MACMU 95 13 -
PQLLWDITFRFYGPD OXYR_MOUSE 95 13 -
PQLLWDITFRFYGPD OXYR_PIG 95 13 -
PQLLWDITFRFYGPD OXYR_RAT 95 13 -
PQLLWDITFRFYGPD OXYR_BOVIN 95 13 -
PQLLWDITFRFYGPD OXYR_SHEEP 95 13 -
PQLCWDITYRFRGPD V1AR_MOUSE 107 13 -
PQLCWDITYRFRGPD V1AR_RAT 107 13 -
PQLIWDITFRFYAPD Q90252 100 13 -
PQMCWDITYRFRGPD V1AR_HUMAN 107 13 -
PQLGWDITYRFRGPD V1AR_SHEEP 106 13 -
PQLCWEITFRFYGPD Q90352 80 13 -
PQLLWDITYRFQGPD V1BR_HUMAN 90 13 -
PQLIWDITFRFYGPD Q90334 99 13 -
PQLLWDITYRFQGSD V1BR_RAT 90 13 -
PQLAWDATYRFRGPD V2R_PIG 94 13 -
PQLAWDATDRFRGPD V2R_BOVIN 95 13 -
PQLAWDATDRFHGPD O88721 95 13 -
PQLAWDATDRFHGPD V2R_RAT 95 13 -
PQLAWDATDRFRGPD O77808 94 13 -
PQLAWKATDRFRGPD V2R_HUMAN 95 13 -
PQLIWDITERFYGGD Q25397 106 13 -
PQLISDVTIVFHGDD Q25396 126 13 -

Motif 4 width=15
Element Seqn Id St Int Rpt
DCWAVFIQPWGPKAY OXYR_HUMAN 186 76 -
DCWAVFIQPWGPKAY OXYR_MACMU 186 76 -
DCWAVFIQPWGPKAY OXYR_MOUSE 186 76 -
DCWAVFIQPWGPKAY OXYR_PIG 186 76 -
DCWAVFIQPWGPKAY OXYR_RAT 186 76 -
DCWAVFIQPWGPKAY OXYR_BOVIN 186 76 -
DCWAVFIQPWGPKAY OXYR_SHEEP 186 76 -
DCWATFIPPWGTRAY V1AR_MOUSE 204 82 -
DCWATFIQPWGTRAY V1AR_RAT 204 82 -
DCRADFIQPWGPKAY Q90252 191 76 -
DCWATFIQPWGSRAY V1AR_HUMAN 202 80 -
DCWANFIHPWGLPAY V1AR_SHEEP 201 80 -
DCWGHFIEPWGIRAY Q90352 175 80 -
DCWADFGFPWGPRAY V1BR_HUMAN 185 80 -
DCWGDFVQPWGAKAY Q90334 190 76 -
DCWADFYFSWGPRAY V1BR_RAT 185 80 -
DCWASFAEPWGLRAY V2R_PIG 190 81 -
DCWARFAEPWGLRAY V2R_BOVIN 190 80 -
DCWARFAEPWGLRAY O88721 191 81 -
DCWARFAEPWGLRAY V2R_RAT 191 81 -
DCWAHFAEPWGLRAY O77808 190 81 -
DCWACFAEPWGRRTY V2R_HUMAN 191 81 -
ECWGRFEPPWTLNLY Q25397 202 81 -
DCLATFEPDWGMQAY Q25396 219 78 -

Motif 5 width=13
Element Seqn Id St Int Rpt
CYGLISFKIWQNL OXYR_HUMAN 219 18 -
CYGLISFKIWQNL OXYR_MACMU 219 18 -
CYGLISFKIWQNL OXYR_MOUSE 219 18 -
CYGLISFKIWQNL OXYR_PIG 219 18 -
CYGLISFKIWQNL OXYR_RAT 219 18 -
CYGLISFKIWQNL OXYR_BOVIN 219 18 -
CYGLISFKIWQNL OXYR_SHEEP 219 18 -
CYGFICYHIWRNV V1AR_MOUSE 237 18 -
CYGFICYHIWRNI V1AR_RAT 237 18 -
CYGLISYKIWQNI Q90252 224 18 -
CYGFICYNIWCNV V1AR_HUMAN 235 18 -
CYGFICYHIWRKV V1AR_SHEEP 234 18 -
CYGFICHSIWKNI Q90352 208 18 -
CYSLICHEICKNL V1BR_HUMAN 218 18 -
CYGLISFKIWQNF Q90334 223 18 -
CYGLICHEIYKNL V1BR_RAT 218 18 -
CQVLIFREIHTSL V2R_PIG 223 18 -
CQVLIFREIHASL V2R_BOVIN 223 18 -
CQVLIFREIHASL O88721 224 18 -
CQVLIFREIHASL V2R_RAT 224 18 -
CQVLIFREIHSSL O77808 223 18 -
CQVLIFREIHASL V2R_HUMAN 224 18 -
AYVSICCTIWRKY Q25397 235 18 -
CYGRICHVVWMSV Q25396 252 18 -

Motif 6 width=15
Element Seqn Id St Int Rpt
ISKAKIRTVKMTFII OXYR_HUMAN 266 34 -
ISKAKIRTVKMTFII OXYR_MACMU 266 34 -
ISKAKIRTVKMTFII OXYR_MOUSE 265 33 -
ISKAKIRTVKMTFII OXYR_PIG 268 36 -
ISKAKIRTVKMTFII OXYR_RAT 265 33 -
ISKAKIRTVKMTFIV OXYR_BOVIN 268 36 -
ISKAKIRTVKMTFIV OXYR_SHEEP 268 36 -
ISRAKIRTVKMTFVI V1AR_MOUSE 287 37 -
ISRAKIRTVKMTFVI V1AR_RAT 288 38 -
ISKAKIRTVKMTFII Q90252 265 28 -
ISRAKIRTVKMTFVI V1AR_HUMAN 282 34 -
ISRAKIRTVKMTFVI V1AR_SHEEP 282 35 -
ISRAKLRTVKMTLVI Q90352 247 26 -
ISRAKIRTVKMTFVI V1BR_HUMAN 272 41 -
VSKAKITTVKMTFVI Q90334 266 30 -
ISRAKIRTVKMTFVI V1BR_RAT 273 42 -
VSAAMAKTARMTLVI V2R_PIG 261 25 -
VSAAVAKTVKMTLVI V2R_BOVIN 261 25 -
VSAAMAKTVRMTLVI O88721 262 25 -
VSAAMAKTVRMTLVI V2R_RAT 262 25 -
VSAAMAKTVRMTLVI O77808 261 25 -
VSAAVAKTVRMTLVI V2R_HUMAN 262 25 -
FSRAKLKTVKLTFVV Q25397 313 65 -
VSKSKMKTIKLTLTV Q25396 329 64 -

Motif 7 width=8
Element Seqn Id St Int Rpt
VQMWSVWD OXYR_HUMAN 294 13 -
VQMWSVWD OXYR_MACMU 294 13 -
VQMWSVWD OXYR_MOUSE 293 13 -
VQMWSVWD OXYR_PIG 296 13 -
VQMWSVWD OXYR_RAT 293 13 -
VQMWSVWD OXYR_BOVIN 296 13 -
KQMWSVWD OXYR_SHEEP 296 13 -
VQMWSVWD V1AR_MOUSE 315 13 -
VQMWSVWD V1AR_RAT 316 13 -
VQMWSVWD Q90252 293 13 -
IQMWSVWD V1AR_HUMAN 310 13 -
IQMWSAWD V1AR_SHEEP 310 13 -
VQMWSVWD Q90352 275 13 -
VQMWSVWD V1BR_HUMAN 300 13 -
VQMWSAWD Q90334 294 13 -
VQMWSVWD V1BR_RAT 301 13 -
VQLWSVWD V2R_PIG 289 13 -
VQLWAAWD V2R_BOVIN 289 13 -
VQLWAAWD O88721 290 13 -
VQLWAAWD V2R_RAT 290 13 -
VQLWAAWD O77808 289 13 -
VQLWAAWD V2R_HUMAN 290 13 -
SQLWWLYD Q25397 341 13 -
VQMWSAFD Q25396 357 13 -

Motif 8 width=9
Element Seqn Id St Int Rpt
LLASLNSCC OXYR_HUMAN 316 14 -
LLASLNSCC OXYR_MACMU 316 14 -
LLASLNSCC OXYR_MOUSE 315 14 -
LLASLNSCC OXYR_PIG 318 14 -
LLASLNSCC OXYR_RAT 315 14 -
LLASLNSCC OXYR_BOVIN 318 14 -
LLASLNSCC OXYR_SHEEP 318 14 -
LLASLNSCC V1AR_MOUSE 340 17 -
LLASLNSCC V1AR_RAT 341 17 -
LLGSLNSCC Q90252 315 14 -
LLGSLNSCC V1AR_HUMAN 335 17 -
LLASLNSCC V1AR_SHEEP 335 17 -
LLASLNSCC Q90352 300 17 -
LLGNLNSCC V1BR_HUMAN 325 17 -
LLASLNSCC Q90334 316 14 -
LLGNLSSCC V1BR_RAT 326 17 -
LLASLNSCT V2R_PIG 311 14 -
LLASLNSCT V2R_BOVIN 311 14 -
LLASLNSCT O88721 312 14 -
LLASLNSCT V2R_RAT 312 14 -
LLASLNSCT O77808 311 14 -
LLASLNSCT V2R_HUMAN 312 14 -
LLASLNSCC Q25397 362 13 -
LLASLNSCT Q25396 379 14 -