| Literature References | 1. STRASSER, P., GIMONA, M., MOESSLER, H., HERZOG, M. AND SMALL, J.V.
Mammalian calponin. Identification and expression of genetic variants.
FEBS LETT. 330 13-18 (1993).
2. APPLEGATE, D., FENG, W., GREEN, R.S.and TAUBMAN, M.B.
Cloning and expression of a novel acidic calponin isoform from rat
aortic vascular smooth muscle.
J.BIOL.CHEM. 269 10683-10690 (1994).
3. SAMAHA, F.F., IP, H.S., MORRISEY, E.E., SELTZER, J., TANG, Z.,
SOLWAY, J. AND PARMACEK, M.S.
Developmental pattern of expression and genomic organization of the
calponin-h1 gene. a contractile smooth muscle cell marker.
J.BIOL.CHEM. 271 395-403 (1996).
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| Documentation | Calponin is a smooth muscle-specific, actin-, tropomyosin- and calmodulin-
binding protein believed to be involved in regulation or modulation of
contraction [1,2]; interaction of the protein with actin inhibits actomyosin
MgATPase activity. Multiple isoforms are found in smooth muscle [2].
Calponin is a basic protein of ~34 Kd [3]. The protein contains three
repeats of a well-conserved 26-residue domain, which is also found in a
variety of proteins whose physiological role is as yet unclear (these
include vertebrate smooth muscle protein, Drosophila synchronous flight
muscle protein, C.elegans unc-87 protein, and rat neuronal protein NP25).
CALPONIN is a 6-element fingerprint that provides a signature for the
calponins. The fingerprint was derived from an initial alignment of 6
sequences: the motifs were drawn from short conserved sections, focusing
on those regions that characterise the calponins but distinguish them from
the rest of the SM22/calponin family - motif 4 includes the C-terminus of
the first calponin domain repeat; motif 5 lies within the second domain
repeat and includes the central part of the region encoded by PROSITE
pattern CALPONIN (PS01052); and motif 6 includes the third repeat. Two
iterations on OWL30.2 were required to reach convergence, at which point
a true set comprising 12 sequences was identified. Several partial matches
were also found, all of which are fragments and/or SM22/calponin family
members that fail to match one or more motifs.
An update on SPTR37_9f identified a true set of 10 sequences.
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| Sequence Titles | CLP1_HUMAN CALPONIN H1, SMOOTH MUSCLE (BASIC CALPONIN) - HOMO SAPIENS (HUMAN).
CLP1_MOUSE CALPONIN H1, SMOOTH MUSCLE (BASIC CALPONIN) - MUS MUSCULUS (MOUSE).
CLP1_PIG CALPONIN H1, SMOOTH MUSCLE (BASIC CALPONIN) - SUS SCROFA (PIG).
CLP1_RAT CALPONIN H1, SMOOTH MUSCLE (BASIC CALPONIN) - RATTUS NORVEGICUS (RAT).
CLP2_MOUSE CALPONIN H2, SMOOTH MUSCLE - MUS MUSCULUS (MOUSE).
CLPA_RAT CALPONIN, ACIDIC ISOFORM (CALPONIN, NON-MUSCLE ISOFORM) - RATTUS NORVEGICUS (RAT).
CLPO_CHICK CALPONIN ALPHA AND BETA, SMOOTH MUSCLE - GALLUS GALLUS (CHICKEN).
O93547 CALPONIN H3 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q15417 ACIDIC CALPONIN - HOMO SAPIENS (HUMAN).
Q92578 NEUTRAL CALPONIN - HOMO SAPIENS (HUMAN).
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