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PR00860

Identifier
MTVERTEBRATE  [View Relations]  [View Alignment]  
Accession
PR00860
No. of Motifs
3
Creation Date
06-MAR-1998  (UPDATE 27-JUN-1999)
Title
Vertebrate metallothionein signature
Database References

PROSITE; PS00203 METALLOTHIONEIN_VRT
BLOCKS; BL00203
PFAM; PF00131 metalthio
INTERPRO; IPR000006
PDB; 1MHU; 2MHU
SCOP; 1MHU; 2MHU
Literature References
1. KAGI, J.H.R.
Overview of Metallothioneins.
METHODS ENZYMOL. 205 613-626 (1991).
 
2. KAGI, J.H.R. AND KOJIMA, Y.
Chemistry and biochemistry of metallothionein.
EXPERIENTIA SUPPL. 52 25-61 (1987).
 
3. KAGI, J.H.R. AND SCHAFFER, A.
Biochemistry of metallothionein.
BIOCHEMISTRY 27 8509-8515 (1988).
 
4. FOWLER, B.A., HILDEBRAND, C.E., KOJIMA, Y. AND WEBB, M.
Nomenclature of metallothionein.
EXPERIENTIA SUPPL. 52 21 (1987).
 
5. KOJIMA, Y.
Definitions and nomenclature of metallothioneins.
METHODS ENZYMOL. 205 8-10 (1991).
 
6. BINZ, P.-A. AND KAGI, J.H.R.
Molecular evolution of the metallothionein. Suggestions for a natural 
classification system.
FOURTH INTERNATIONAL MEETING ON METALLOTHIONEIN, KANSAS CITY (USA), 1997.

Documentation
Metallothioneins (MT) are small proteins that bind heavy metals, such as
zinc, copper, cadmium, nickel, etc.. They have a high content of cysteine
residues that bind the metal ions through clusters of thiolate bonds [1-3]
(http://www.unizh.ch/~mtpage/MT.html). An empirical classification into
three classes has been proposed by Fowler et al. [4] and Kojima [5]. Members
of class I are defined to include polypeptides related in the positions of
their cysteines to equine MT-1B, and include mammalian MTs as well as MTs 
from crustaceans and molluscs. Class II groups MTs from a variety of 
species, including sea urchins, fungi, insects and cyanobacteria. Class
III MTs are atypical polypeptides composed of gamma-glutamylcysteinyl
units [4]. 
 
This original classification system has been found to be limited, in the
sense that it does not allow clear differentiation of patterns of structural
similarities, either between or within classes. Consequently, all class I
and class II MTs (the proteinaceous sequences) have now been grouped into
families of phylogenetically-related and thus alignable sequences [6]
(http://www.unizh.ch/~mtpage/classif.html). This system subdivides the MT
superfamily into families, subfamilies, subgroups, and isolated isoforms
and alleles. 
 
The metallothionein superfamily comprises all polypeptides that resemble
equine renal metallothionein in several respects [4]: e.g., low molecular
weight; high metal content; amino acid composition with high Cys and low
aromatic residue content; unique sequence with characteristic distribution
of cysteines, and spectroscopic manifestations indicative of metal thiolate
clusters. A MT family subsumes MTs that share particular sequence-specific 
features and are thought to be evolutionarily related. The inclusion of a
MT within a family presupposes that its amino acid sequence is alignable 
with that of all members. Fifteen MT families have been characterised, each
family being identified by its number and its taxonomic range: e.g., Family
1: vertebrate MTs. 
 
Vertebrate family 1 MTs are 60-68 residue proteins, in which 19 totally-
conserved cysteines bind 7 bivalent metal ions. The protein comprises two
structural domains (designated alpha and beta), which contain 9 and 11
cysteines that bind 3 and 4 bivalent metal ions, respectively. There are 7
metal-binding sites, denoted CD1-CD7, each comprising several Cys residues.
 
MTVERTEBRATE is a 3-element fingerprint that provides a signature for
family 1 metallothioneins. The fingerprint was derived from an initial
alignment of 6 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length and encode a number of
residues involved in metal binding - motif 1 lies in the beta domain and
includes Cys residues involved in the CD3 and CD4 metal-binding sites;
motif 2, which spans the alpha and beta domains, includes part of the first 
alpha-helix and the CD2, CD3, CD5 and CD7 sites (motifs 1 and 2 span the
region encoded by the PROSITE pattern METALLOTHIONEIN_VRT (PS00203)); and
motif 3 lies in the alpha domain, spanning the second helix - it includes
the CD1, CD5, CD6 and CD7 sites. Two iterations on OWL30.0 were required to
reach convergence, at which point a true set comprising 8 sequences was
identified. Five partial matches were also found, all of which are fragments
that lack either the first or the last motif.
 
An update on SPTR37_9f identified a true set of 78 sequences.
Summary Information
78 codes involving  3 elements
0 codes involving 2 elements
Composite Feature Index
3787878
2000
123
True Positives
MT1A_BOVIN    MT1A_HORSE    MT1A_HUMAN    MT1A_RABIT    
MT1B_HORSE MT1B_HUMAN MT1B_SHEEP MT1C_SHEEP
MT1E_HUMAN MT1F_HUMAN MT1G_HUMAN MT1H_BOVIN
MT1H_HUMAN MT1I_HUMAN MT1K_HUMAN MT1L_HUMAN
MT1R_HUMAN MT1_CANFA MT1_CERAE MT1_COLLI
MT1_CRIGR MT1_MOUSE MT1_PIG MT1_RAT
MT2A_RABIT MT2B_RABIT MT2C_RABIT MT2D_RABIT
MT2E_RABIT MT2H_BOVIN MT2_BOVIN MT2_CERAE
MT2_COLLI MT2_CRIGR MT2_HUMAN MT2_MESAU
MT2_MOUSE MT2_RAT MT2_STECO MT3_BOVIN
MT3_HORSE MT3_HUMAN MT3_MOUSE MT3_PIG
MT3_RAT MT4_HUMAN MT4_MOUSE MTA_ONCMY
MTA_SPAAU MTA_THECR MTB_ONCMY MTB_SALSA
MT_BRARE MT_CARAU MT_CHAAC MT_CHICK
MT_ESOLU MT_GADMO MT_NOEBA MT_OREMO
MT_PERFL MT_PLEPL MT_PSEAM MT_RUTRU
MT_TREBE MT_XENLA MT_ZOAVI O13257
O13258 O13259 O13269 O42152
O73914 O93450 O93571 O93593
O93609 Q92044
Sequence Titles
MT1A_BOVIN  METALLOTHIONEIN-IA (MT-1A) (MTC) - BOS TAURUS (BOVINE), AND OVIS ARIES (SHEEP). 
MT1A_HORSE METALLOTHIONEIN-IA (MT-1A) - EQUUS CABALLUS (HORSE).
MT1A_HUMAN METALLOTHIONEIN-IA (MT-1A) - HOMO SAPIENS (HUMAN).
MT1A_RABIT METALLOTHIONEIN-IA (MT-1A) - ORYCTOLAGUS CUNICULUS (RABBIT).
MT1B_HORSE METALLOTHIONEIN-IB (MT-IB) - EQUUS CABALLUS (HORSE).
MT1B_HUMAN METALLOTHIONEIN-IB (MT-1B) - HOMO SAPIENS (HUMAN).
MT1B_SHEEP METALLOTHIONEIN-IB - OVIS ARIES (SHEEP).
MT1C_SHEEP METALLOTHIONEIN-IC - OVIS ARIES (SHEEP).
MT1E_HUMAN METALLOTHIONEIN-IE (MT-1E) - HOMO SAPIENS (HUMAN).
MT1F_HUMAN METALLOTHIONEIN-IF (MT-1F) - HOMO SAPIENS (HUMAN).
MT1G_HUMAN METALLOTHIONEIN-IG (MT-1G) - HOMO SAPIENS (HUMAN).
MT1H_BOVIN METALLOTHIONEIN-I, HIPPOCAMPAL (MT-1) - BOS TAURUS (BOVINE).
MT1H_HUMAN METALLOTHIONEIN-IH (MT-1H) (METALLOTHIONEIN-0) (MT-0) - HOMO SAPIENS (HUMAN).
MT1I_HUMAN METALLOTHIONEIN-II (MT-1I) - HOMO SAPIENS (HUMAN).
MT1K_HUMAN METALLOTHIONEIN-IK (MT-1K) - HOMO SAPIENS (HUMAN).
MT1L_HUMAN METALLOTHIONEIN-IL (MT-1L) (MT1X) - HOMO SAPIENS (HUMAN).
MT1R_HUMAN METALLOTHIONEIN-IR (MT-1R) - HOMO SAPIENS (HUMAN).
MT1_CANFA METALLOTHIONEIN-I (MT-I) - CANIS FAMILIARIS (DOG).
MT1_CERAE METALLOTHIONEIN-I (MT-I) - CERCOPITHECUS AETHIOPS (GREEN MONKEY) (GRIVET).
MT1_COLLI METALLOTHIONEIN-I (MT-1) - COLUMBA LIVIA (DOMESTIC PIGEON).
MT1_CRIGR METALLOTHIONEIN-I (MT-I) - CRICETULUS GRISEUS (CHINESE HAMSTER).
MT1_MOUSE METALLOTHIONEIN-I (MT-I) - MUS MUSCULUS (MOUSE).
MT1_PIG METALLOTHIONEIN-I (MT-I) - SUS SCROFA (PIG).
MT1_RAT METALLOTHIONEIN-I (MT-I) - RATTUS NORVEGICUS (RAT).
MT2A_RABIT METALLOTHIONEIN-IIA (MT-2A) - ORYCTOLAGUS CUNICULUS (RABBIT).
MT2B_RABIT METALLOTHIONEIN-IIB (MT-2B) - ORYCTOLAGUS CUNICULUS (RABBIT).
MT2C_RABIT METALLOTHIONEIN-IIC (MT-2C) - ORYCTOLAGUS CUNICULUS (RABBIT).
MT2D_RABIT METALLOTHIONEIN-IID (MT-2D) - ORYCTOLAGUS CUNICULUS (RABBIT).
MT2E_RABIT METALLOTHIONEIN-IIE (MT-2E) - ORYCTOLAGUS CUNICULUS (RABBIT).
MT2H_BOVIN METALLOTHIONEIN-II, HIPPOCAMPAL (MT-2) - BOS TAURUS (BOVINE).
MT2_BOVIN METALLOTHIONEIN-II (MT-II) - BOS TAURUS (BOVINE), AND OVIS ARIES (SHEEP).
MT2_CERAE METALLOTHIONEIN-II (MT-II) - CERCOPITHECUS AETHIOPS (GREEN MONKEY) (GRIVET), AND MACACA FASCICULARIS (CRAB EATING MACAQUE) (CYNOMOLGUS MONKEY).
MT2_COLLI METALLOTHIONEIN-II (MT-2) - COLUMBA LIVIA (DOMESTIC PIGEON).
MT2_CRIGR METALLOTHIONEIN-II (MT-II) - CRICETULUS GRISEUS (CHINESE HAMSTER).
MT2_HUMAN METALLOTHIONEIN-II (MT-II) - HOMO SAPIENS (HUMAN).
MT2_MESAU METALLOTHIONEIN-II (MT-II) - MESOCRICETUS AURATUS (GOLDEN HAMSTER).
MT2_MOUSE METALLOTHIONEIN-II (MT-II) - MUS MUSCULUS (MOUSE).
MT2_RAT METALLOTHIONEIN-II (MT-II) - RATTUS NORVEGICUS (RAT).
MT2_STECO METALLOTHIONEIN-II (MT-II) - STENELLA COERULEOALBA (STRIPED DOLPHIN).
MT3_BOVIN METALLOTHIONEIN-III (MT-III) (GROWTH INHIBITORY FACTOR) (GIF) - BOS TAURUS (BOVINE).
MT3_HORSE METALLOTHIONEIN-III (MT-III) (GROWTH INHIBITORY FACTOR) (GIF) - EQUUS CABALLUS (HORSE).
MT3_HUMAN METALLOTHIONEIN-III (MT-III) (GROWTH INHIBITORY FACTOR) (GIF) (GIFB) - HOMO SAPIENS (HUMAN).
MT3_MOUSE METALLOTHIONEIN-III (MT-III) (GROWTH INHIBITORY FACTOR) (GIF) - MUS MUSCULUS (MOUSE).
MT3_PIG METALLOTHIONEIN-III (MT-III) (GROWTH INHIBITORY FACTOR) (GIF) - SUS SCROFA (PIG).
MT3_RAT METALLOTHIONEIN-III (MT-III) (GROWTH INHIBITORY FACTOR) (GIF) - RATTUS NORVEGICUS (RAT).
MT4_HUMAN METALLOTHIONEIN-IV (MT-IV) - HOMO SAPIENS (HUMAN).
MT4_MOUSE METALLOTHIONEIN-IV (MT-IV) - MUS MUSCULUS (MOUSE).
MTA_ONCMY METALLOTHIONEIN A (MT-A) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI), SALMO SALAR (ATLANTIC SALMON), AND SALVELINUS ALPINUS (ARCTIC CHAR).
MTA_SPAAU METALLOTHIONEIN A (MT A) - SPARUS AURATA (GILTHEAD SEA BREAM).
MTA_THECR METALLOTHIONEIN A (MT-A) - THERMARCES CERBERUS.
MTB_ONCMY METALLOTHIONEIN B (MT-B) - ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI), AND SALVELINUS ALPINUS (ARCTIC CHAR).
MTB_SALSA METALLOTHIONEIN B (MT-B) - SALMO SALAR (ATLANTIC SALMON).
MT_BRARE METALLOTHIONEIN (MT) - BRACHYDANIO RERIO (ZEBRAFISH) (ZEBRA DANIO).
MT_CARAU METALLOTHIONEIN (MT) - CARASSIUS AURATUS (GOLDFISH).
MT_CHAAC METALLOTHIONEIN (MT) - CHAENOCEPHALUS ACERATUS.
MT_CHICK METALLOTHIONEIN (MT) - GALLUS GALLUS (CHICKEN), MELEAGRIS GALLOPAVO (COMMON TURKEY), PHASIANUS COLCHICUS COLCHICUS (RING-NECKED PHEASANT), ANAS PLATYRHYNCHOS (DOMESTIC DUCK), AND CAIRINA MOSCHATA (MUSCOVY DUCK).
MT_ESOLU METALLOTHIONEIN (MT) - ESOX LUCIUS (NORTHERN PIKE).
MT_GADMO METALLOTHIONEIN (MT) - GADUS MORHUA (ATLANTIC COD).
MT_NOEBA METALLOTHIONEIN (MT) - NOEMACHEILUS BARBATULUS (STONE LOACH).
MT_OREMO METALLOTHIONEIN (MT) - OREOCHROMIS MOSSAMBICUS (MOZAMBIQUE TILAPIA) (TILAPIA MOSSAMBICA).
MT_PERFL METALLOTHIONEIN (MT) - PERCA FLUVIATILIS (PERCH).
MT_PLEPL METALLOTHIONEIN (MT) - PLEURONECTES PLATESSA (PLAICE).
MT_PSEAM METALLOTHIONEIN (MT) - PSEUDOPLEURONECTA AMERICANUS (WINTER FLOUNDER).
MT_RUTRU METALLOTHIONEIN (MT) - RUTILUS RUTILUS (ROACH).
MT_TREBE METALLOTHIONEIN (MT) - TREMATOMUS BERNACCHII, AND CHIONODRACO RASTROSPINOSUS.
MT_XENLA METALLOTHIONEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
MT_ZOAVI METALLOTHIONEIN (MT) - ZOARCES VIVIPARUS.
O13257 METALLOTHIONEIN (MT) - LIZA AURATA.
O13258 METALLOTHIONEIN (MT) - CHIONODRACO HAMATUS, AND GYMNODRACO ACUTICEPS (ANTARCTIC DRAGONFISH).
O13259 METALLOTHIONEIN (MT) - CHIONODRACO HAMATUS, AND MORONE SAXATILIS (STRIPED BASS).
O13269 METALLOTHIONEIN (MT) - CYPRINUS CARPIO (COMMON CARP).
O42152 METALLOTHIONEIN (MT) - AMBYSTOMA MEXICANUM (AXOLOTL).
O73914 METALLOTHIONEIN (MT) - NOTOTHENIA CORIICEPS NEGLECTA (BLACK ROCKCOD) (YELLOWBELLY ROCKCOD), AND CHIONODRACO RASTROSPINOSUS.
O93450 METALLOTHIONEIN (MT) - PARACHAENICHTHYS CHARCOTI.
O93571 METALLOTHIONEIN (MT) - ICTALURUS PUNCTATUS (CHANNEL CATFISH).
O93593 METALLOTHIONEIN (MT) - CHAENOCEPHALUS ACERATUS.
O93609 METALLOTHIONEIN (MT) - TREMATOMUS BERNACCHII.
Q92044 METALLOTHIONEIN (MT) - CYPRINODON SP.
Scan History
OWL30_0    2  100  NSINGLE    
SPTR37_9f 2 100 NSINGLE
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
CSCPTGGSCSCAG MT1A_BOVIN 5 5 -
CECSKTGSCNCGG MTB_SALSA 4 4 -
CECSKTGSCNCGG MT_ESOLU 4 4 -
CSCPTGGSCTCAG MT1A_HORSE 5 5 -
CSCSPVGSCACAG MT1L_HUMAN 5 5 -
CSCVAGESCTCAG MT1B_HORSE 5 5 -
CSCSTGSSCSCAG MT1C_SHEEP 5 5 -
CSCPTGGSCSCAG MT1_PIG 5 5 -
CSCATGNSCTCAS MT1A_RABIT 5 5 -
CSCATGGSCTCTG MT1A_HUMAN 5 5 -
CECSKTGTCNCGG MT_ZOAVI 4 4 -
CSCSTGSTCTCSS MT1_CRIGR 5 5 -
CPCAAGGTCTCGD MT1_COLLI 6 6 -
CSCATDGSCSCSG MT2_MESAU 5 5 -
CECSKTGTCKCGD MTA_THECR 4 4 -
CPCPSGGSCTCAD MT3_HUMAN 6 6 -
SCAAAGVSCTCAS MT1K_HUMAN 6 6 -
CTCAAGDSCSCAG MT_CHICK 6 6 -
CKCETGASCSCGT MT_XENLA 6 6 -
CVCMSGGICMCGD MT4_HUMAN 6 6 -

Motif 2 width=14
Element Seqn Id St Int Rpt
PSCKKSCCSCCPVG MT1A_BOVIN 27 9 -
TSCKKSCCPCCPSG MTB_SALSA 26 9 -
TSCKKSCCSCCPSG MT_ESOLU 26 9 -
TSCKKSCCSCCPGG MT1A_HORSE 27 9 -
TSCKKSCCSCCPVG MT1L_HUMAN 27 9 -
ASCKKSCCSCCPVG MT1B_HORSE 27 9 -
PSCKKSCCSCCPVG MT1C_SHEEP 27 9 -
TSCKKSCCSCCPAG MT1_PIG 27 9 -
TSCKKSCCSCCPAG MT1A_RABIT 27 9 -
NSCKKSCCSCCPMS MT1A_HUMAN 27 9 -
TTCKKSCCPCCPSG MT_ZOAVI 26 9 -
TSCKKSCCSCCPVG MT1_CRIGR 27 9 -
TSCKKGCCSCCPAG MT1_COLLI 28 9 -
TTCKKSCCSCCPVG MT2_MESAU 27 9 -
TTCKKSCCPCCPSG MTA_THECR 26 9 -
TSCKKSCCSCCPAE MT3_HUMAN 28 9 -
TSCKKSCCSCCPVG MT1K_HUMAN 28 9 -
RSCRKSCCSCCPAG MT_CHICK 28 9 -
TSCKKSCCSCCPAE MT_XENLA 28 9 -
KTCRKSCCPCCPPG MT4_HUMAN 28 9 -

Motif 3 width=10
Element Seqn Id St Int Rpt
CAKCAQGCVC MT1A_BOVIN 41 0 -
CSKCASGCVC MTB_SALSA 40 0 -
CSKCASGCIC MT_ESOLU 40 0 -
CARCAQGCVC MT1A_HORSE 41 0 -
CAKCAQGCIC MT1L_HUMAN 41 0 -
CAKCAQGCVC MT1B_HORSE 41 0 -
CAKCAQGCIC MT1C_SHEEP 41 0 -
CARCAQGCIC MT1_PIG 41 0 -
CTKCAQGCIC MT1A_RABIT 41 0 -
CAKCAQGCIC MT1A_HUMAN 41 0 -
CTKCASGCVC MT_ZOAVI 40 0 -
CSKCAQGCVC MT1_CRIGR 41 0 -
CAKCAQGCVC MT1_COLLI 42 0 -
CAKCSQGCVC MT2_MESAU 41 0 -
CTKCASGCVC MTA_THECR 40 0 -
CEKCAKDCVC MT3_HUMAN 42 0 -
CAKCAQGCIC MT1K_HUMAN 42 0 -
CNNCAKGCVC MT_CHICK 42 0 -
CSKCSQGCHC MT_XENLA 42 0 -
CAKCARGCIC MT4_HUMAN 42 0 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
CSCATGGSCTCAG MT1E_HUMAN 5 5 -
CSCSTGGSCTCAG MT1_CANFA 5 5 -
CSCATGGSCSCAS MT1R_HUMAN 5 5 -
CSCPTGGSCSCAG MT1A_BOVIN 5 5 -
CSCAAGVSCTCAG MT1F_HUMAN 5 5 -
CSCSTGGSCTCSS MT1_RAT 5 5 -
CSCSTGGSCTCTS MT1_MOUSE 5 5 -
CSCAAGDSCTCAG MT2_HUMAN 5 5 -
CSCATGVSCTCAD MT1_CERAE 5 5 -
CSCAAGVSCTCAG MT1I_HUMAN 5 5 -
CECSKTGSCNCGG MTB_SALSA 4 4 -
CECSKTGSCNCGG MT_ESOLU 4 4 -
CSCTTGGSCACAG MT1B_HUMAN 5 5 -
CSCATGGSCTCAN MT2H_BOVIN 5 5 -
CSCPTSGSCSCAG MT1B_SHEEP 5 5 -
CSCEAGGSCACAG MT1H_HUMAN 5 5 -
CECSKTGTCNCGG MTA_SPAAU 4 4 -
CSCPTGGSCTCAG MT1A_HORSE 5 5 -
CSCVAGDSCTCAG MT2_CERAE 5 5 -
CSCSPVGSCACAG MT1L_HUMAN 5 5 -
CSCTAGGSCACPG MT2_STECO 5 5 -
CSCAAGVSCTCAS MT1G_HUMAN 5 5 -
CSCATGDSCACAS MT1H_BOVIN 5 5 -
CSCTAGESCTCAG MT2_BOVIN 5 5 -
CSCVAGESCTCAG MT1B_HORSE 5 5 -
CSCATGDSCTCAS MT2B_RABIT 5 5 -
CSCSTGSSCSCAG MT1C_SHEEP 5 5 -
CSCPTGGSCSCAG MT1_PIG 5 5 -
CSCATGNSCTCAS MT1A_RABIT 5 5 -
CECSKTGSCNCGG MTB_ONCMY 4 4 -
CECSKSGTCNCGG MT_TREBE 4 4 -
CSCATDGSCSCAG MT2_RAT 5 5 -
CECSKGGTCNCGG MT_PERFL 4 4 -
CSCATDGSCSCAG MT2_CRIGR 5 5 -
CDCSKSGTCNCGG O13259 4 4 -
CECSKTGKCSCGG O13257 4 4 -
CSCATGGSCTCTG MT1A_HUMAN 5 5 -
CECSKTGTCNCGG MT_ZOAVI 4 4 -
CSCSTGSTCTCSS MT1_CRIGR 5 5 -
CECTKSGTCNCGG MT_CHAAC 4 4 -
CECAKTGTCNCGG MT_OREMO 4 4 -
CPCAAGGTCTCGD MT1_COLLI 6 6 -
CSCASDGSCSCAG MT2_MOUSE 5 5 -
CECSKSGTCNCGG O73914 4 4 -
CSCATDGSCSCSG MT2_MESAU 5 5 -
CDCSKTGTCNCGA MT_NOEBA 4 4 -
CACATGGSCSCAG O42152 3 3 -
CECAKTGACNCGA MT_BRARE 4 4 -
CDCSKSGTCNCGG O13258 4 4 -
CECSKSGNCNCGG O93593 4 4 -
CECSKSGNCNCGG O93450 4 4 -
CQCSKSGTCNCGG O93609 4 4 -
CSCATRDSCACAS MT2D_RABIT 5 5 -
CSCATRDSCACAS MT2E_RABIT 5 5 -
CDCAKTGACNCGA MT_CARAU 4 4 -
CECSKTGTCNCGT O93571 4 4 -
CDCAKTGTCNCGA MT_RUTRU 4 4 -
CPCPTGGSCTCAG MT3_PIG 6 6 -
CECSKTGTCNCGG MT_PLEPL 4 4 -
CECSKTGTCNCGG MT_PSEAM 4 4 -
CECSKTGTCKCGD MTA_THECR 4 4 -
CECSKTGKCNCGT Q92044 4 4 -
CDCAKTGTCNCGA O13269 4 4 -
CPCPTGGSCTCSG MT3_HORSE 6 6 -
CDCAKTGTCNCGT MT_GADMO 4 4 -
CPCPTGGSCTCSD MT3_MOUSE 6 6 -
CPCPTGGSCTCSD MT3_RAT 6 6 -
CPCPSGGSCTCAD MT3_HUMAN 6 6 -
CECSKTGSCNCGG MTA_ONCMY 4 4 -
SCAAAGVSCTCAS MT1K_HUMAN 6 6 -
SCAAAGDSCTCAN MT2A_RABIT 6 6 -
CPCPTGGSCTCSD MT3_BOVIN 6 6 -
CTCAAGDSCSCAG MT_CHICK 6 6 -
SCATAGDSCTCAN MT2C_RABIT 6 6 -
CKCETGASCSCGT MT_XENLA 6 6 -
CTCAAGDSCSCAG MT2_COLLI 6 6 -
CTCMSGGICICGD MT4_MOUSE 6 6 -
CVCMSGGICMCGD MT4_HUMAN 6 6 -

Motif 2 width=14
Element Seqn Id St Int Rpt
TSCKKSCCSCCPVG MT1E_HUMAN 27 9 -
TSCKKSCCSCCPVG MT1_CANFA 27 9 -
TSCKKSCCSCCPMG MT1R_HUMAN 27 9 -
PSCKKSCCSCCPVG MT1A_BOVIN 27 9 -
TSCKKSCCSCCPVG MT1F_HUMAN 27 9 -
TSCKKSCCSCCPVG MT1_RAT 27 9 -
TSCKKSCCSCCPVG MT1_MOUSE 27 9 -
TSCKKSCCSCCPVG MT2_HUMAN 27 9 -
TSCKKSCCSCCPVG MT1_CERAE 27 9 -
TSCKKSCCSCCPVG MT1I_HUMAN 27 9 -
TSCKKSCCPCCPSG MTB_SALSA 26 9 -
TSCKKSCCSCCPSG MT_ESOLU 26 9 -
TSCKKCCCSCCPVG MT1B_HUMAN 27 9 -
ASCKKSCCSCCPVG MT2H_BOVIN 27 9 -
PSCKKSCCSCCPVG MT1B_SHEEP 27 9 -
TSCKKSCCSCCPLG MT1H_HUMAN 27 9 -
TSCKKSCCSCCPAG MTA_SPAAU 26 9 -
TSCKKSCCSCCPGG MT1A_HORSE 27 9 -
TSCKKSCCSCCPVG MT2_CERAE 27 9 -
TSCKKSCCSCCPVG MT1L_HUMAN 27 9 -
TSCKKSCCSCCPVG MT2_STECO 27 9 -
TSCKKSCCSCCPVG MT1G_HUMAN 27 9 -
TSCKKSCCSCCPVG MT1H_BOVIN 27 9 -
ASCKKSCCSCCPVG MT2_BOVIN 27 9 -
ASCKKSCCSCCPVG MT1B_HORSE 27 9 -
TSCKKSCCSCCPAG MT2B_RABIT 27 9 -
PSCKKSCCSCCPVG MT1C_SHEEP 27 9 -
TSCKKSCCSCCPAG MT1_PIG 27 9 -
TSCKKSCCSCCPAG MT1A_RABIT 27 9 -
TSCKKSCCPCCPSD MTB_ONCMY 26 9 -
TSCKKSCCPCCPSG MT_TREBE 26 9 -
TSCKKSCCSCCPVG MT2_RAT 27 9 -
TTCKKSCCPCCPSG MT_PERFL 26 9 -
TTCKKSCCSCCPVG MT2_CRIGR 27 9 -
TSCKKSCCPCCPSG O13259 26 9 -
TSCKKSCCPCCPSG O13257 26 9 -
NSCKKSCCSCCPMS MT1A_HUMAN 27 9 -
TTCKKSCCPCCPSG MT_ZOAVI 26 9 -
TSCKKSCCSCCPVG MT1_CRIGR 27 9 -
TSCKKSCCPCCPSG MT_CHAAC 26 9 -
KSCKKSCCDCCPSG MT_OREMO 26 9 -
TSCKKGCCSCCPAG MT1_COLLI 28 9 -
TSCKKSCCSCCPVG MT2_MOUSE 27 9 -
KSCKKSCCPCCPSG O73914 26 9 -
TTCKKSCCSCCPVG MT2_MESAU 27 9 -
TTCKKSCCSCCPSG MT_NOEBA 26 9 -
TSCKKSCCSCCPSE O42152 25 9 -
TTCKKSCCSCCPSG MT_BRARE 26 9 -
KSCKKSCCPCCPSG O13258 26 9 -
KSCKKSCCPCCPSG O93593 26 9 -
KSCKKSCCPCCPSG O93450 26 9 -
KSCKKSCCPCCPSG O93609 26 9 -
TSCKKSCCSCCPAG MT2D_RABIT 27 9 -
TSCKKSCCSCCPAG MT2E_RABIT 27 9 -
TTCKKSCCSCCPSG MT_CARAU 26 9 -
ACCKKSCCSCCPSG O93571 26 9 -
TTCKKSCCTCCPSG MT_RUTRU 26 9 -
TSCKKSCCSCCPAE MT3_PIG 28 9 -
TTCNKSCCPCCPSG MT_PLEPL 26 9 -
TTCNKSCCPCCPSG MT_PSEAM 26 9 -
TTCKKSCCPCCPSG MTA_THECR 26 9 -
KCCKKSCCSCCPSG Q92044 26 9 -
KTCKKSCCPCCPSG O13269 26 9 -
TSCKKSCCSCCPAE MT3_HORSE 28 9 -
TKCKKSCCECCPSG MT_GADMO 26 9 -
TNCKKSCCSCCPAG MT3_MOUSE 28 9 -
TNCKKSCCSCCPAG MT3_RAT 28 9 -
TSCKKSCCSCCPAE MT3_HUMAN 28 9 -
SCKKASCCDCCPSG MTA_ONCMY 27 10 -
TSCKKSCCSCCPVG MT1K_HUMAN 28 9 -
TSCKKSCCSCCPPG MT2A_RABIT 28 9 -
ASCKKSCCSCCPAE MT3_BOVIN 28 9 -
RSCRKSCCSCCPAG MT_CHICK 28 9 -
TSCKKSCCSCCPPG MT2C_RABIT 28 9 -
TSCKKSCCSCCPAE MT_XENLA 28 9 -
QSCRKSCCSCCPAS MT2_COLLI 28 9 -
KTCRKSCCPCCPPG MT4_MOUSE 28 9 -
KTCRKSCCPCCPPG MT4_HUMAN 28 9 -

Motif 3 width=10
Element Seqn Id St Int Rpt
CAKCAQGCVC MT1E_HUMAN 41 0 -
CAKCAQGCIC MT1_CANFA 41 0 -
CAKCAQGCVC MT1R_HUMAN 41 0 -
CAKCAQGCVC MT1A_BOVIN 41 0 -
CSKCAQGCVC MT1F_HUMAN 41 0 -
CSKCAQGCVC MT1_RAT 41 0 -
CSKCAQGCVC MT1_MOUSE 41 0 -
CAKCAQGCIC MT2_HUMAN 41 0 -
CAKCAQGCVC MT1_CERAE 41 0 -
CAKCAQGCIC MT1I_HUMAN 41 0 -
CSKCASGCVC MTB_SALSA 40 0 -
CSKCASGCIC MT_ESOLU 40 0 -
CAKCAQGCVC MT1B_HUMAN 41 0 -
CAKCAQGCIC MT2H_BOVIN 41 0 -
CAKCAQGCVC MT1B_SHEEP 41 0 -
CAKCAQGCIC MT1H_HUMAN 41 0 -
CSKCASGCVC MTA_SPAAU 40 0 -
CARCAQGCVC MT1A_HORSE 41 0 -
CAKCAQGCIC MT2_CERAE 41 0 -
CAKCAQGCIC MT1L_HUMAN 41 0 -
CAKCAQGCIC MT2_STECO 41 0 -
CAKCAQGCIC MT1G_HUMAN 41 0 -
CAKCAQGCIC MT1H_BOVIN 41 0 -
CAKCAQGCVC MT2_BOVIN 41 0 -
CAKCAQGCVC MT1B_HORSE 41 0 -
CTKCAQGCIC MT2B_RABIT 41 0 -
CAKCAQGCIC MT1C_SHEEP 41 0 -
CARCAQGCIC MT1_PIG 41 0 -
CTKCAQGCIC MT1A_RABIT 41 0 -
CSKCASGCVC MTB_ONCMY 40 0 -
CTKCASGCVC MT_TREBE 40 0 -
CAKCSQGCIC MT2_RAT 41 0 -
CPKCASGCVC MT_PERFL 40 0 -
CAKCSQGCVC MT2_CRIGR 41 0 -
CTKCASGCVC O13259 40 0 -
CSKCASGCVC O13257 40 0 -
CAKCAQGCIC MT1A_HUMAN 41 0 -
CTKCASGCVC MT_ZOAVI 40 0 -
CSKCAQGCVC MT1_CRIGR 41 0 -
CTKCASGCVC MT_CHAAC 40 0 -
CSKCASGCVC MT_OREMO 40 0 -
CAKCAQGCVC MT1_COLLI 42 0 -
CAKCSQGCIC MT2_MOUSE 41 0 -
CTKCASGCVC O73914 40 0 -
CAKCSQGCVC MT2_MESAU 41 0 -
CSKCASGCVC MT_NOEBA 40 0 -
CEKCGQGCVC O42152 39 0 -
CSKCASGCVC MT_BRARE 40 0 -
CTKCASGCVC O13258 40 0 -
CTKCASGCVC O93593 40 0 -
CTKCASGCVC O93450 40 0 -
CTKCASGCVC O93609 40 0 -
CTKCAQGCIC MT2D_RABIT 41 0 -
CTKCAQGCIC MT2E_RABIT 41 0 -
CSKCASGCVC MT_CARAU 40 0 -
CSKCASGCVC O93571 40 0 -
CSKCASGCVC MT_RUTRU 40 0 -
CEKCAKDCVC MT3_PIG 42 0 -
CPKCASGCVC MT_PLEPL 40 0 -
CPKCASGCVC MT_PSEAM 40 0 -
CTKCASGCVC MTA_THECR 40 0 -
CSKCASGCVC Q92044 40 0 -
CSKCASGCVC O13269 40 0 -
CEKCAKDCVC MT3_HORSE 42 0 -
CSKCASGCAC MT_GADMO 40 0 -
CEKCAKDCVC MT3_MOUSE 42 0 -
CEKCAKDCVC MT3_RAT 42 0 -
CEKCAKDCVC MT3_HUMAN 42 0 -
CSKCASGCVC MTA_ONCMY 41 0 -
CAKCAQGCIC MT1K_HUMAN 42 0 -
CAKCAQGCIC MT2A_RABIT 42 0 -
CEKCAKDCVC MT3_BOVIN 42 0 -
CNNCAKGCVC MT_CHICK 42 0 -
CAKCAQGCIC MT2C_RABIT 42 0 -
CSKCSQGCHC MT_XENLA 42 0 -
CSNCAKGCVC MT2_COLLI 42 0 -
CAKCARGCIC MT4_MOUSE 42 0 -
CAKCARGCIC MT4_HUMAN 42 0 -