| Literature References | 1. LEITERMANN, K. AND OHMAN, J.L.
Cat allergen 1: biochemical, antigenic, and allergenic properties.
J.ALLERGY CLIN.IMMUNOL. 74 147-153 (1984).
2. MORGENSTERN, J.P., GRIFFITH, I.J., BRAUER, A.W., ROGERS, B.L., BOND, J.F.,
CHAPMAN, M.D. AND KUO, M.C.
Amino acid sequence of Fel dI, the major allergen of the domestic cat:
protein sequence analysis and cDNA cloning.
PROC.NATL.ACAD.SCI.U.S.A. 88 9690-9694(1991).
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| Documentation | Allergen 1 from the domestic cat, Felis domesticus, is an important agent
in human allergic reactions [1]. The protein is expressed in saliva and
sebaceous glands. The complete primary structure of Fel dI has been
determined [2]. The allergen is composed of two polypeptide chains, which
have been shown to be encoded by different genes [2]. The protein exists as
a heterotetramer of non-covalently linked disulphide-linked heterodimers of
chains 1 and 2. Fel dI chain 1 shares sequence similarity with rabbit
uteroglobin; chain 2 is a glycoprotein with N-linked oligosaccharides [2].
FELALLERGEN is a 4-element fingerprint that provides a signature for
feline Fel dI allergens. The fingerprint was derived from an initial
alignment of 5 sequences: the motifs were drawn from short conserved regions
spanning virtually the full alignment length - motifs 1 and 4 reside at the
N- and C-termini respectively, and include the regions encoded by PROSITE
patterns UTEROGLOBIN_1 (PS00403) and UTEROGLOBIN_2 (PS00404), each of which
contains a Cys residue that is thought to be involved in interchain
disulphide bond formation. Two iterations on OWL29.6 were required to reach
convergence, at which point a true set comprising 6 sequences was identified.
A single partial match was also found, a mouse salivary androgen-binding
protein that matches motifs 1,2 and 4.
An update on SPTR37_9f identified a true set of 3 sequences.
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