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PR00798

Identifier
TOGAVIRIN  [View Relations]  [View Alignment]  
Accession
PR00798
No. of Motifs
6
Creation Date
21-JUN-1997  (UPDATE 07-JUN-1999)
Title
Togavirin (S3) serine protease family signature
Database References

PFAM; PF00944 Alpha_core
INTERPRO; IPR000930
Literature References
1. RAWLINGS, N.D. AND BARRETT, A.J.
Families of serine peptidases.
METHODS ENZYMOL. 244 19-61 (1994).
 
2. RAWLINGS, N.D AND BARRETT, A.J.
Evolutionary families of peptidases.
BIOCHEM.J. 290 205-218 (1993).
 
3. CHOI, H.K., TONG, L., MINOR, W., DUMAS, P., BOEGE, U., ROSSMANN, M.G.
AND WENGLER, G.
Structure of sindbis virus core protein reveals a chymotrypsin-like serine
proteinase and the organization of the virion.
NATURE 354 37-43 (1991).

Documentation
Proteolytic enzymes that use serine in their catalytic machinery are 
widespread and numerous, being found in viruses, bacteria and eukaryotes
[1]. They encompass a range of peptidase activity, including exopeptidase,
endopeptidase, oligopeptidase and omega-peptidase. More than 20 serine
protease families (denoted S1 - S27) have been identified, which have been
grouped into 6 clans (SA, SB, SC, SE, SF and SG) on the basis of structural
and functional similarities [1]. Structures are known for four of the clans
(SA, SB, SC and SE): these appear to be unrelated, suggesting at least four
evolutionary origins of serine peptidase, and possibly many more [1].
 
There are similarities in the reaction mechanisms of several peptidases
from different evolutionary origins. Chymotrypsin, subtilisin and
carboxypeptidase C clans exploit a catalytic triad of serine, aspartate
and histidine, in which serine acts as a nucleophile, aspartate as an
electrophile and histidine as a base [1]. The geometric orientations of
the catalytic residues are similar between families, despite different 
protein folds [1]. The linear arrangement of the catalytic residues
commonly reflect clan relationships. For example, in the chymotrypsin clan
(SA), the catalytic triad is ordered HDS, whereas it is ordered DHS in the
subtilisin clan (SB), and SDH in the carboxypeptidase clan (SC) [1,2].
 
Togavirin, also known as sindbis virus core endopeptidase, is a serine 
protease resident at the N-terminus of the p130 polyprotein of togaviruses
[1]. The polyprotein also includes structural proteins for the nucleocapsid
core and for the glycoprotein spikes [1]. Togavirin is only active while
part of the polyprotein, cleavage at a Trp-Ser bond resulting in total lack
of activity [1]. Mutagenesis studies have identified the location of the
His-Asp-Ser catalytic triad, and X-ray studies have revealed the protein
fold to be similar to that of chymotrypsin [1,3].
 
TOGAVIRIN is a 6-element fingerprint that provides a signature for the 
togavirin (sindbis virus core endopeptidase) (S3) family of serine
proteases. The fingerprint was derived from an initial alignment of 7
sequences: the motifs were drawn from conserved regions spanning virtually
the full length of the protease - motifs 2, 3 and 5 contain the catalytic
His, Asp and Ser residues respectively. Two iterations on OWL29.3 were
required to reach convergence, at which point a true set comprising 41
sequences was identified.
 
An update on SPTR37_9f identified a true set of 48 sequences.
Summary Information
48 codes involving  6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
6484848484848
5000000
4000000
3000000
2000000
123456
True Positives
O41516        O72768        O90164        O90369        
O90371 O91628 P89913 P89946
POLS_EEEV POLS_EEEV3 POLS_EEVV3 POLS_EEVV8
POLS_EEVVE POLS_EEVVM POLS_EEVVP POLS_EEVVT
POLS_ONNVG POLS_RRVN POLS_RRVT POLS_SFV
POLS_SINDO POLS_SINDV POLS_WEEV Q08359
Q66579 Q66593 Q66595 Q86925
Q87048 Q87049 Q88430 Q88432
Q88613 Q88614 Q88628 Q88678
Q88691 Q88696 Q88790 Q88792
Q88793 Q88794 Q88795 Q88796
Q88797 Q88798 Q88799 Q88979
Sequence Titles
O41516      STRUCTURAL PROTEIN PRECURSOR - VENEZUELAN EQUINE ENCEPHALITIS VIRUS. 
O72768 POLYPROTEIN PRECURSOR - EASTERN EQUINE ENCEPHALITIS VIRUS (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
O90164 STRUCTURAL POLYPROTEIN - VENEZUELAN EQUINE ENCEPHALITIS VIRUS.
O90369 STRUCTURAL POLYPROTEIN - O'NYONG-NYONG VIRUS.
O90371 STRUCTURAL POLYPROTEIN - IGBO ORA VIRUS.
O91628 STRUCTURAL POLYPROTEIN - VENEZUELAN EQUINE ENCEPHALITIS VIRUS.
P89913 STRUCTURAL POLYPROTEIN - SINDBIS VIRUS.
P89946 STRUCTURAL POLYPROTEIN - BARMAH FOREST VIRUS.
POLS_EEEV STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - EASTERN EQUINE ENCEPHALITIS VIRUS (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
POLS_EEEV3 STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - EASTERN EQUINE ENCEPHALITIS VIRUS (STRAIN VA33[TEN BROECK]) (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
POLS_EEVV3 STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN 3880).
POLS_EEVV8 STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN TC-83).
POLS_EEVVE STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN EVERGLADES FE3-7C).
POLS_EEVVM STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN MENA II).
POLS_EEVVP STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN P676).
POLS_EEVVT STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN TRINIDAD DONKEY).
POLS_ONNVG STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - O'NYONG-NYONG VIRUS (STRAIN GULU) (ONN).
POLS_RRVN STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - ROSS RIVER VIRUS (STRAIN NB5092) (RRV).
POLS_RRVT STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - ROSS RIVER VIRUS (STRAIN T48) (RRV).
POLS_SFV STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - SEMLIKI FOREST VIRUS (SFV).
POLS_SINDO STRUCTURAL POLYPROTEIN (P130) [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - SINDBIS VIRUS (SUBTYPE OCKELBO / STRAIN EDSBYN 82-5).
POLS_SINDV STRUCTURAL POLYPROTEIN (P130) [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - SINDBIS VIRUS (STRAINS HRSP AND HRLP).
POLS_WEEV STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - WESTERN EQUINE ENCEPHALITIS VIRUS.
Q08359 STRUCTURAL POLYPROTEIN (CONTAINS: COAT PROTEIN C; SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE) - EASTERN EQUINE ENCEPHALITIS VIRUS (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
Q66579 RNA SEQUENCE - EASTERN EQUINE ENCEPHALITIS VIRUS (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
Q66593 STRUCTURAL POLYPROTEIN - VENEZUELAN EQUINE ENCEPHALITIS VIRUS.
Q66595 STRUCTURAL POLYPROTEIN - VENEZUELAN EQUINE ENCEPHALITIS VIRUS.
Q86925 POLYPROTEIN 2 - AURA VIRUS.
Q87048 CAPSID PROTEIN - SEMLIKI FOREST VIRUS (SFV).
Q87049 VIRION PROTEIN - SEMLIKI FOREST VIRUS (SFV).
Q88430 STRUCTURAL POLYPROTEIN - SINDBIS-LIKE VIRUS.
Q88432 STRUCTURAL POLYPROTEIN - SINDBIS-LIKE VIRUS.
Q88613 STRUCTURAL POLYPROTEIN - ROSS RIVER VIRUS.
Q88614 STRUCTURAL POLYPROTEIN - ROSS RIVER VIRUS.
Q88628 POLYPROTEIN - CHIKUNGUNYA VIRUS.
Q88678 POLYPROTEIN - EASTERN EQUINE ENCEPHALITIS VIRUS (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
Q88691 STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - VENEZUELAN EQUINE ENCEPHALITIS VIRUS (STRAIN TRINIDAD DONKEY).
Q88696 STRUCTURAL POLYPROTEIN [CONTAINS: COAT PROTEIN C (EC 3.4.21.-); SPIKE GLYCOPROTEINS E3, E2 AND E1; 6 KD PEPTIDE] - WESTERN EQUINE ENCEPHALITIS VIRUS.
Q88790 STRUCTURAL POLYPROTEIN - EASTERN EQUINE ENCEPHALITIS VIRUS (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
Q88792 STRUCTURAL POLYPROTEIN - EASTERN EQUINE ENCEPHALITIS VIRUS (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
Q88793 STRUCTURAL POLYPROTEIN - EASTERN EQUINE ENCEPHALITIS VIRUS (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
Q88794 STRUCTURAL POLYPROTEIN - EASTERN EQUINE ENCEPHALITIS VIRUS (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
Q88795 STRUCTURAL POLYPROTEIN - EASTERN EQUINE ENCEPHALITIS VIRUS (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
Q88796 STRUCTURAL POLYPROTEIN - EASTERN EQUINE ENCEPHALITIS VIRUS (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
Q88797 STRUCTURAL POLYPROTEIN - EASTERN EQUINE ENCEPHALITIS VIRUS (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
Q88798 STRUCTURAL POLYPROTEIN - EASTERN EQUINE ENCEPHALITIS VIRUS (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
Q88799 STRUCTURAL POLYPROTEIN - EASTERN EQUINE ENCEPHALITIS VIRUS (EASTERN EQUINE ENCEPHALOMYELITIS VIRUS).
Q88979 STRUCTURAL POLYPROTEIN - VENEZUELAN EQUINE ENCEPHALITIS VIRUS.
Scan History
OWL29_3    2  100  NSINGLE    
SPTR37_9f 2 49 NSINGLE
Initial Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
RMCMKLESDKTFPI POLS_EEEV3 102 102 -
RMCMKLESDKTFPI POLS_EEEV 101 101 -
RMCMKLESDKTFPI POLS_WEEV 101 101 -
RMVMKLESDKTFPI POLS_EEVVE 116 116 -
RMCMKIENDCIFEV POLS_RRVT 113 113 -
RMCMKIENDCIFEV POLS_ONNVG 103 103 -
RMALKLEADRLFDV POLS_SINDO 105 105 -

Motif 2 width=25
Element Seqn Id St Int Rpt
GYACVVGGRVFKPLHVEGRIDNEQL POLS_EEEV3 123 7 -
GYACVVGGRVFKPLHVEGRIDNEQL POLS_EEEV 122 7 -
GYACVVGGRLMKPLHVEGKIDNEQL POLS_WEEV 122 7 -
GYACVVGGKLFRPMHVEGKIDNDVL POLS_EEVVE 137 7 -
GYACLVGDKVMKPAHVKGTIDNPDL POLS_RRVT 134 7 -
GYACLVGDKVMKPAHVKGTIDNADL POLS_ONNVG 124 7 -
GHALAMEGKVMKPLHVKGTIDHPVL POLS_SINDO 127 8 -

Motif 3 width=25
Element Seqn Id St Int Rpt
AAIKLKKASIYDLEYGDVPQCMKSD POLS_EEEV3 148 0 -
AAIKLKKASIYDLEYGDVPQCMKSD POLS_EEEV 147 0 -
AAVKLKKASMYDLEYGDVPQNMKSD POLS_WEEV 147 0 -
AALKTKKASKYDLEYADVPQNMRAD POLS_EEVVE 162 0 -
AKLTYKKSSKYDLECAQIPVHMKSD POLS_RRVT 159 0 -
AKLAFKRSSKYDLECAQIPVHMKSD POLS_ONNVG 149 0 -
SKLKFTKSSAYDMEFAQLPVNMRSE POLS_SINDO 152 0 -

Motif 4 width=25
Element Seqn Id St Int Rpt
TLQYTSDKPPGFYNWHHGAVQYENN POLS_EEEV3 173 0 -
TLQYTSDKPPGFYNWHHGAVQYENN POLS_EEEV 172 0 -
TLQYTSDKPPGFYNWHHGAVQYENG POLS_WEEV 172 0 -
TFKYTHEKPQGYYSWHHGAVQYENG POLS_EEVVE 187 0 -
ASKYTHEKPEGHYNWHHGAVQYSGG POLS_RRVT 184 0 -
ASKFTHEKPEGYYNWHHGAVQYSGG POLS_ONNVG 174 0 -
AFTYTSEHPEGFYNWHHGAVQYSGG POLS_SINDO 177 0 -

Motif 5 width=25
Element Seqn Id St Int Rpt
RFTVPRGVGGKGDSGRPILDNKGRV POLS_EEEV3 198 0 -
RFTVPRGVGGKGDSGRPILDNKGRV POLS_EEEV 197 0 -
RFTVPRGVGGKGDSGRPILDNRGRV POLS_WEEV 197 0 -
RFTVPRGVGARGDSGRPILDNQGRV POLS_EEVVE 212 0 -
RFTIPTGAGKPGDSGRPIFDNKGRV POLS_RRVT 209 0 -
RFTIPTGAGKPGDSGRPIFDNKGRV POLS_ONNVG 199 0 -
RFTIPRGVGGRGDSGRPIMDNSGRV POLS_SINDO 202 0 -

Motif 6 width=27
Element Seqn Id St Int Rpt
VAIVLGGVNEGSRTALSVVTWNQKGVT POLS_EEEV3 223 0 -
VAIVQGGVNEGSRTALSVVTWNQKGVT POLS_EEEV 222 0 -
VAIVLGGANEGTRTALSVVTWNQKGVT POLS_WEEV 222 0 -
VAIVLGGVNEGSRTALSVVMWNEKGVT POLS_EEVVE 237 0 -
VAIVLGGANEGARTALSVVTWTKDMVT POLS_RRVT 234 0 -
VAIVLGGANEGTRTALSVVTWNKDIVT POLS_ONNVG 224 0 -
VAIVLGGADEGTRTALSVVTWNSKGKT POLS_SINDO 227 0 -
Final Motifs
Motif 1  width=14
Element Seqn Id St Int Rpt
RMCMKLESDKTFPI POLS_EEEV3 102 102 -
RMCMKLESDKTFPI Q08359 103 103 -
RMCMKLESDKTFPI Q66579 102 102 -
RMCMKLESDKTFPI Q88678 103 103 -
RMCMKLESDKTFPI Q88790 103 103 -
RMCMKLESDKTFPI Q88792 103 103 -
RMCMKLESDKTFPI Q88793 103 103 -
RMCMKLESDKTFPI Q88794 103 103 -
RMCMKLESDKTFPI Q88795 103 103 -
RMCMKLESDKTFPI Q88796 103 103 -
RMCMKLESDKTFPI Q88797 103 103 -
RMCMKLESDKTFPI Q88798 103 103 -
RMCMKLESDKTFPI Q88799 103 103 -
RMCMKLESDKTFPI O72768 100 100 -
RMCMKLESDKTFPI POLS_EEEV 101 101 -
RMCMKLESDKTFPI POLS_WEEV 101 101 -
RMCMKLESDKTFPI Q88696 101 101 -
RMVMKLESDKTFPI O90164 117 117 -
RMVMKLESDKTFPI Q88691 117 117 -
RMVMKLESDKTFPI Q66595 117 117 -
RMVMKLESDKTFPI Q66593 117 117 -
RMVMKLESDKTFPI POLS_EEVVT 117 117 -
RMVMKLESDKTFPI POLS_EEVVP 117 117 -
RMVMKLESDKTFPI POLS_EEVV8 117 117 -
RMVMKLESDKTFPI POLS_EEVV3 117 117 -
RMVMKLESDKTFPI O91628 117 117 -
RMVMKLESDKTFPI POLS_EEVVE 116 116 -
RMVMKLESDKTFPI POLS_EEVVM 116 116 -
RMVMKLESDKTFPI Q88979 116 116 -
RMVMKLESDKTFPI O41516 117 117 -
RMCMKIENDCIFEV POLS_SFV 110 110 -
RMCMKIENDCIFEV Q87048 110 110 -
RMCMKIENDCIFEV Q87049 2 2 -
RMCMKIENDCIFEV POLS_RRVT 113 113 -
RMCMKIENDCIFEV Q88613 113 113 -
RMCMKIENDCIFEV Q88614 113 113 -
RMCMKIENDCIFEV POLS_RRVN 113 113 -
RMCMKIENDCIFEV O90369 103 103 -
RMCMKIENDCIFEV O90371 103 103 -
RMCMKIENDCIFEV POLS_ONNVG 103 103 -
RMCMKIENDCIFEV Q88628 104 104 -
RNCMKIENDCIFPV P89946 96 96 -
RMALKLEADRLFDV POLS_SINDO 105 105 -
RMALKLEADRLFDV Q88432 105 105 -
RMALKLEADRLFDV Q88430 105 105 -
RMALKLEADRLFDV POLS_SINDV 105 105 -
RMALKLEADRLFDV P89913 107 107 -
RTALKFEADRTFVG Q86925 108 108 -

Motif 2 width=25
Element Seqn Id St Int Rpt
GYACVVGGRVFKPLHVEGRIDNEQL POLS_EEEV3 123 7 -
GYACVVGGRVFKPLHVEGRIDNEQL Q08359 124 7 -
GYACVVGGRVFKPLHVEGRIDNEQL Q66579 123 7 -
GYACVVGGRVFKPLHVEGRIDNEQL Q88678 124 7 -
GYACVVGGRVFKPLHVEGRIDNEQL Q88790 124 7 -
GYACVVGGRVFKPLHVEGRIDNEQL Q88792 124 7 -
GYACVVGGRVFKPLHVEGRIDNEQL Q88793 124 7 -
GYACVVGGRVFKPLHVEGRIDNEQL Q88794 124 7 -
GYACVVGGRVFKPLHVEGRIDNEQL Q88795 124 7 -
GYACVVGGRVFKPLHVEGRIDNEQL Q88796 124 7 -
GYACVVGGRVFKPLHVEGRIDNEQL Q88797 124 7 -
GYACVVGGRVFKPLHVEGRIDNEQL Q88798 124 7 -
GYACVVGGRVFKPLHVEGRIDNEQL Q88799 124 7 -
GYACVVGGRVFKPLHVEGRIDNEQL O72768 121 7 -
GYACVVGGRVFKPLHVEGRIDNEQL POLS_EEEV 122 7 -
GYACVVGGRLMKPLHVEGKIDNEQL POLS_WEEV 122 7 -
GYACVVGGRLMKPLHVEGKIDNEQL Q88696 122 7 -
GYACVVGGKLFRPMHVEGKIDNDVL O90164 138 7 -
GYACVVGGKLFRPMHVEGKIDNDVL Q88691 138 7 -
GYACVVGGKLFRPMHVEGKIDNDVL Q66595 138 7 -
GYACVVGGKLFRPMHVEGKIDNDVL Q66593 138 7 -
GYACVVGGKLFRPMHVEGKIDNDVL POLS_EEVVT 138 7 -
GYACVVGGKLFRPMHVEGKIDNDVL POLS_EEVVP 138 7 -
GYACVVGGKLFRPMHVEGKIDNDVL POLS_EEVV8 138 7 -
GYACVVGGKLFRPMHVEGKIDNDVL POLS_EEVV3 138 7 -
GYACVVGGKLFRPMHVEGKIDNDVL O91628 138 7 -
GYACVVGGKLFRPMHVEGKIDNDVL POLS_EEVVE 137 7 -
GYACVVGGKLFRPLHVEGKIDNDVL POLS_EEVVM 137 7 -
GYACVVGGKLFRPLHVEGKIDNDVL Q88979 137 7 -
GYACVVGGKLFRPMHVEGKIDNETL O41516 138 7 -
GYACLVGDKVMKPAHVKGVIDNADL POLS_SFV 131 7 -
GYACLVGDKVMKPAHVKGVIDNADL Q87048 131 7 -
GYACLVGDKVMKPAHVKGVIDNADL Q87049 23 7 -
GYACLVGDKVMKPAHVKGTIDNPDL POLS_RRVT 134 7 -
GYACLVGDKVMKPAHVKGTIDNPDL Q88613 134 7 -
GYACLVGDKVMKPAHVKGTIDNPDL Q88614 134 7 -
GYACLVGDKVMKPAHVKGTIDNPDL POLS_RRVN 134 7 -
GYACLVGDKVMKPAHVKGTIDNADL O90369 124 7 -
GYACLVGDKVMKPAHVKGTIDNADL O90371 124 7 -
GYACLVGDKVMKPAHVKGTIDNADL POLS_ONNVG 124 7 -
GYACLVGDKVMKPAHVKGTIDNADL Q88628 125 7 -
GYACLVGDKVMKPAHVKGTIDNPEL P89946 117 7 -
GHALAMEGKVMKPLHVKGTIDHPVL POLS_SINDO 127 8 -
GHALAMEGKVMKPLHVKGTIDHPVL Q88432 127 8 -
GHALAMEGKVMKPLHVKGTIDHPVL Q88430 127 8 -
GHALAMEGKVMKPLHVKGTIDHPVL POLS_SINDV 127 8 -
GHALAMEGKVMKPLHVKGTIDHPVL P89913 129 8 -
GYAVAMEGKVIKPLYVKGTIDHPAL Q86925 130 8 -

Motif 3 width=25
Element Seqn Id St Int Rpt
AAIKLKKASIYDLEYGDVPQCMKSD POLS_EEEV3 148 0 -
AAIKLKKASIYDLEYGDVPQCMKSD Q08359 149 0 -
AAIKLKKASIYDLEYGDVPQCMKSD Q66579 148 0 -
AAIKLKKASIYDLEYGDVPQCMKSD Q88678 149 0 -
AAIKLKKASIYDLEYGDVPQCMKSD Q88790 149 0 -
AAIKLKKASIYDLEYGDVPQCMKSD Q88792 149 0 -
AAIKLKKASIYDLEYGDVPQCMKSD Q88793 149 0 -
AAIKLKKASIYDLEYGDVPQCMKSD Q88794 149 0 -
AAIKLKKASIYDLEYGDVPQCMKSD Q88795 149 0 -
AAIKLKKASIYDLEYGDVPQCMKSD Q88796 149 0 -
AAIKLKKASIYDLEYGDVPQCMKSD Q88797 149 0 -
AAIKLKKASIYDLEYGDVPQCMKSD Q88798 149 0 -
AAIKLKKASIYDLEYGDVPQCMKSD Q88799 149 0 -
AAIKLKKASIYDLEYGDVPQCMKSD O72768 146 0 -
AAIKLKKASIYDLEYGDVPQCMKSD POLS_EEEV 147 0 -
AAVKLKKASMYDLEYGDVPQNMKSD POLS_WEEV 147 0 -
AAVKLKKASMYDLEYGDVPQNMKSD Q88696 147 0 -
AALKTKKASKYDLEYADVPQNMRAD O90164 163 0 -
AALKTKKASKYDLEYADVPQNMRAD Q88691 163 0 -
AALKTKKASKYDLEYADVPQNMRAD Q66595 163 0 -
AALKTKKASKYDLEYADVPQNMRAD Q66593 163 0 -
AALKTKKASKYDLEYADVPQNMRAD POLS_EEVVT 163 0 -
AALKTKKASKYDLEYADVPQNMRAD POLS_EEVVP 163 0 -
AALKTKKASKYDLEYADVPQNMRAD POLS_EEVV8 163 0 -
AALKTKKASKYDLEYADVPQNMRAD POLS_EEVV3 163 0 -
AALKTKKASKYDLEYADVPQNMRAD O91628 163 0 -
AALKTKKASKYDLEYADVPQNMRAD POLS_EEVVE 162 0 -
SSLKTKKASKYDLEYADVPQSMRAD POLS_EEVVM 162 0 -
SSLKTKKASKYDLEYADVPQSMRAD Q88979 162 0 -
ASLKTKKASKYDLEYADVPQSMRAD O41516 163 0 -
AKLAFKKSSKYDLECAQIPVHMRSD POLS_SFV 156 0 -
AKLAFKKSSKYDLECAQIPVHMRSD Q87048 156 0 -
AKLAFKKSSKYDLECAQIPVHMRSD Q87049 48 0 -
AKLTYKKSSKYDLECAQIPVHMKSD POLS_RRVT 159 0 -
AKLTYKKSSKYDLECAQIPVHMKSD Q88613 159 0 -
AKLTYKKSSKYDLECAQIPVHMKSD Q88614 159 0 -
AKLTYKKSSKYDLECAQIPVHMKSD POLS_RRVN 159 0 -
AKLAFKRSSKYDLECAQIPVHMKSD O90369 149 0 -
AKLAFKRSSKYDLECAQIPVHMKSD O90371 149 0 -
AKLAFKRSSKYDLECAQIPVHMKSD POLS_ONNVG 149 0 -
AKLAFKRSSKYDLECAQIPVHMKSD Q88628 150 0 -
AKLTFKKSSKYDLECAQVPVCMKSD P89946 142 0 -
SKLKFTKSSAYDMEFAQLPVNMRSE POLS_SINDO 152 0 -
SKLKFTKSSAYDMEFAQLPVNMRSE Q88432 152 0 -
SKLKFTKSSAYDMEFAQLPVNMRSE Q88430 152 0 -
SKLKFTKSSAYDMEFAQLPVNMRSE POLS_SINDV 152 0 -
SKLKFTKSSAYDMEFAQLPTNMRSE P89913 154 0 -
AKLKFTKSSSYDMEFAKLPTEMKSD Q86925 155 0 -

Motif 4 width=25
Element Seqn Id St Int Rpt
TLQYTSDKPPGFYNWHHGAVQYENN POLS_EEEV3 173 0 -
TLQYTSDKPPGFYNWHHGAVQYENN Q08359 174 0 -
TLQYTSDKPPGFYNWHHGAVQYENN Q66579 173 0 -
TLQYTSDKPPGFYNWHHGAVQYENN Q88678 174 0 -
TLQYTSDKPPGFYNWHHGAVQYENN Q88790 174 0 -
TLQYTSDKPPGFYNWHHGAVQYENN Q88792 174 0 -
TLQYTSDKPPGFYNWHHGAVQYENN Q88793 174 0 -
TLQYTSDKPPGFYNWHHGAVQYENN Q88794 174 0 -
TLQYTSDKPPGFYNWHHGAVQYENN Q88795 174 0 -
TLQYTSDKPPGFYNWHHGAVQYENN Q88796 174 0 -
TLQYTSDKPPGFYNWHHGAVQYENN Q88797 174 0 -
TLQYTSDKPPGFYNWHHGAVQYENN Q88798 174 0 -
TLQYTSDKPPGFYNWHHGAVQYENN Q88799 174 0 -
TLQYTSDKPPGFYNWHHGAVQYENN O72768 171 0 -
TLQYTSDKPPGFYNWHHGAVQYENN POLS_EEEV 172 0 -
TLQYTSDKPPGFYNWHHGAVQYENG POLS_WEEV 172 0 -
TLQYTSDKPPGFYNWHHGAVQYENG Q88696 172 0 -
TFKYTHEKPQGYYSWHHGAVQYENG O90164 188 0 -
TFKYTHEKPQGYYSWHHGAVQYENG Q88691 188 0 -
TFKYTHEKPQGYYSWHHGAVQYENG Q66595 188 0 -
TFKYTHEKPQGYYSWHHGAVQYENG Q66593 188 0 -
TFKYTHEKPQGYYSWHHGAVQYENG POLS_EEVVT 188 0 -
TFKYTHEKPQGYYSWHHGAVQYENG POLS_EEVVP 188 0 -
TFKYTHEKPQGYYSWHHGAVQYENG POLS_EEVV8 188 0 -
TFKYTHEKPQGYYSWHHGAVQYENG POLS_EEVV3 188 0 -
TFKYTHEKPQGYYSWHHGAVQYENG O91628 188 0 -
TFKYTHEKPQGYYSWHHGAVQYENG POLS_EEVVE 187 0 -
TFKYTHEKPQGYYSWHHGAVQYENG POLS_EEVVM 187 0 -
TFKYTHEKPQGYYSWHHGAVQYENG Q88979 187 0 -
TFKYTHDKPQGYYNWHHGAVQYENG O41516 188 0 -
ASKYTHEKPEGHYNWHHGAVQYSGG POLS_SFV 181 0 -
ASKYTHEKPEGHYNWHHGAVQYSGG Q87048 181 0 -
ASKYTHEKPEGHYNWHHGAVQYSGG Q87049 73 0 -
ASKYTHEKPEGHYNWHHGAVQYSGG POLS_RRVT 184 0 -
ASKYTHEKPEGHYNWHHGAVQYSGG Q88613 184 0 -
ASKYTHEKPEGHYNWHHGAVQYSGG Q88614 184 0 -
ASKYTHEKPEGHYNWHHGAVQYSXG POLS_RRVN 184 0 -
ASKFTHEKPEGYYNWHHGAVQYSGG O90369 174 0 -
ASKFTHEKPEGYYNWHHGAVQYSGG O90371 174 0 -
ASKFTHEKPEGYYNWHHGAVQYSGG POLS_ONNVG 174 0 -
ASKFTHEKPEGYYNWHHGAVQYSGG Q88628 175 0 -
ASKFTHEKPEGHYNWHHGAVQFSNG P89946 167 0 -
AFTYTSEHPEGFYNWHHGAVQYSGG POLS_SINDO 177 0 -
AFTYTSEHPEGFYNWHHGAVQYSGG Q88432 177 0 -
AFTYTSEHPEGFYNWHHGAVQYSGG Q88430 177 0 -
AFTYTSEHPEGFYNWHHGAVQYSGG POLS_SINDV 177 0 -
AFSYTSEHPEGFYNWHHGAVQYSGG P89913 179 0 -
AFGYTTEHPEVFYNWHHGAVQFSGG Q86925 180 0 -

Motif 5 width=25
Element Seqn Id St Int Rpt
RFTVPRGVGGKGDSGRPILDNKGRV POLS_EEEV3 198 0 -
RFTVPRGVGGKGDSGRPILDNKGRV Q08359 199 0 -
RFTVPRGVGGKGDSGRPILDNKGRV Q66579 198 0 -
RFTVPRGVGGKGDSGRPILDNKGRV Q88678 199 0 -
RFTVPRGVGGKGDSGRPILDNKGRV Q88790 199 0 -
RFTVPRGVGGKGDSGRPILDNKGRV Q88792 199 0 -
RFTVPRGVGGKGDSGRPILDNKGRV Q88793 199 0 -
RFTVPRGVGGKGDSGRPILDNKGRV Q88794 199 0 -
RFTVPRGVGGKGDSGRPILDNKGRV Q88795 199 0 -
RFTVPRGVGGKGDSGRPILDNKGRV Q88796 199 0 -
RFTVPRGVGGKGDSGRPILDNKGRV Q88797 199 0 -
RFTVPRGVGGKGDSGRPILDNKGRV Q88798 199 0 -
RFTVPRGVGGKGDSGRPILDNKGRV Q88799 199 0 -
RFTVPRGVGGKGDSGRPILDNKGRV O72768 196 0 -
RFTVPRGVGGKGDSGRPILDNKGRV POLS_EEEV 197 0 -
RFTVPRGVGGKGDSGRPILDNRGRV POLS_WEEV 197 0 -
RFTVPRGVGGKGDSGRPILDNRGRV Q88696 197 0 -
RFTVPKGVGAKGDSGRPILDNQGRV O90164 213 0 -
RFTVPKGVGAKGDSGRPILDNQGRV Q88691 213 0 -
RFTVPKGVGAKGDSGRPILDNQGRV Q66595 213 0 -
RFTVPKGVGAKGDSGRPILDNQGRV Q66593 213 0 -
RFTVPKGVGAKGDSGRPILDNQGRV POLS_EEVVT 213 0 -
RFTVPKGVGAKGDSGRPILDNQGRV POLS_EEVVP 213 0 -
RFTVPKGVGAKGDSGRPILDNQGRV POLS_EEVV8 213 0 -
RFTVPKGVGAKGDSGRPILDNQGRV POLS_EEVV3 213 0 -
RFTVPKGVGAKGDSGRPILDNQGRV O91628 213 0 -
RFTVPRGVGARGDSGRPILDNQGRV POLS_EEVVE 212 0 -
RFTVPKGVGAKGDSGRPILDNQGRV POLS_EEVVM 212 0 -
RFTVPKGVGAKGDSGRPILDNQGRV Q88979 212 0 -
RFTVPKGVGAKGDSGRPILDNQGRV O41516 213 0 -
RFTIPTGAGKPGDSGRPIFDNKGRV POLS_SFV 206 0 -
RFTIPTGAGKPGDSGRPIFDNKGRV Q87048 206 0 -
RFTIPTGAGKPGDRGRPIFDNKGRV Q87049 98 0 -
RFTIPTGAGKPGDSGRPIFDNKGRV POLS_RRVT 209 0 -
RFTIPTGAGKPGDSGRPIFDNKGRV Q88613 209 0 -
RFTIPTGAGKPGDSGRPIFDNKGRV Q88614 209 0 -
RFTIPTGAGKPGDSGRPIFDNKGRV POLS_RRVN 209 0 -
RFTIPTGAGKPGDSGRPIFDNKGRV O90369 199 0 -
RFTIPTGAGKPGDSGRPIFDNKGRV O90371 199 0 -
RFTIPTGAGKPGDSGRPIFDNKGRV POLS_ONNVG 199 0 -
RFTIPTGAGKPGDSGRPIFDNKGRV Q88628 200 0 -
RFTIPTGSGKPGDSGRPIFDNTGKV P89946 192 0 -
RFTIPRGVGGRGDSGRPIMDNSGRV POLS_SINDO 202 0 -
RFTIPRGVGGRGDSGRPIMDNSGRV Q88432 202 0 -
RFTIPRGVGGRGDSGRPIMDNSGRV Q88430 202 0 -
RFTIPRGVGGRGDSGRPIMDNSGRV POLS_SINDV 202 0 -
RFTVPKGAGGKGDSGRPIMDNTGKV P89913 204 0 -
RFTIPTGVGGPGDSGRPILDNSGKV Q86925 205 0 -

Motif 6 width=27
Element Seqn Id St Int Rpt
VAIVLGGVNEGSRTALSVVTWNQKGVT POLS_EEEV3 223 0 -
VAIVLGGVNEGSRTALSVVTWNQKGVT Q08359 224 0 -
VAIVLGGVNEGSRTALSVVTWNQKGVT Q66579 223 0 -
VAIVLGGVNEGSRTALSVVTWNQKGVT Q88678 224 0 -
VAIVLGGVNEGSRTALSVVTWNQKGVT Q88790 224 0 -
VAIVLGGVNEGSRTALSVVTWNQKGVT Q88792 224 0 -
VAIVLGGVNEGSRTALSVVTWNQKGVT Q88793 224 0 -
VAIVLGGVNEGSRTALSVVTWNQKGVT Q88794 224 0 -
VAIVLGGVNEGSRTALSVVTWNQKGVT Q88795 224 0 -
VAIVLGGVNEGSRTALSVVTWNQKGVT Q88796 224 0 -
VAIVLGGVNEGSRTALSVVTWNQKGVT Q88797 224 0 -
VAIVLGGVNEGSRTALSVVTWNQKGVT Q88798 224 0 -
VAIVLGGVNEGSRTALSVVTWNQKGVT Q88799 224 0 -
VAIVQGGVNEGSRTALSVVTWNQKGVT O72768 221 0 -
VAIVQGGVNEGSRTALSVVTWNQKGVT POLS_EEEV 222 0 -
VAIVLGGANEGTRTALSVVTWNQKGVT POLS_WEEV 222 0 -
VAIVLGGANEGTRTALSVVTWNQKGVT Q88696 222 0 -
VAIVLGGVNEGSRTALSVVMWNEKGVT O90164 238 0 -
VAIVLGGVNEGSRTALSVVMWNEKGVT Q88691 238 0 -
VAIVLGGVNEGSRTALSVVMWNEKGVT Q66595 238 0 -
VAIVLGGVNEGSRTALSVVMWNEKGVT Q66593 238 0 -
VAIVLGGVNEGSRTALSVVMWNEKGVT POLS_EEVVT 238 0 -
VAIVLGGVNEGSRTALSVVMWNEKGVT POLS_EEVVP 238 0 -
VAIVLGGVNEGSRTALSVVMWNEKGVT POLS_EEVV8 238 0 -
VAIVLGGVNEGSRTALSVVMWNEKGVT POLS_EEVV3 238 0 -
VAIVLGGVNEGSRTALSVVMWNEKGVT O91628 238 0 -
VAIVLGGVNEGSRTALSVVMWNEKGVT POLS_EEVVE 237 0 -
VAIVLGGVNEGSRTALSVVTWNEKGVT POLS_EEVVM 237 0 -
VAIVLGGVNEGSRTALSVVTWNEKGVT Q88979 237 0 -
VAIVLGGVNEGSKTALSVVMWNEKGVT O41516 238 0 -
VAIVLGGANEGSRTALSVVTWNKDMVT POLS_SFV 231 0 -
VAIVLGGANEGSRTALSVVTWNKDMVT Q87048 231 0 -
VAIVLGGANEGSRTALSVVTWNKDMVT Q87049 123 0 -
VAIVLGGANEGARTALSVVTWTKDMVT POLS_RRVT 234 0 -
VAIVLGGANEGARTALSVVTWTKDMVT Q88613 234 0 -
VAIVLGGANEGARTALSVVTWTKDMVT Q88614 234 0 -
VAIVLGGANEGARTALSVVTWTKDMVT POLS_RRVN 234 0 -
VAIVLGGANEGTRTALSVVTWNKDIVT O90369 224 0 -
VAIVLGGANEGTRTALSVVTWNKDIVT O90371 224 0 -
VAIVLGGANEGTRTALSVVTWNKDIVT POLS_ONNVG 224 0 -
VAIVLGGANEGARTALSVVTWNKDIVT Q88628 225 0 -
VAIVLGGANEGARTALSVVTWNKDMVT P89946 217 0 -
VAIVLGGADEGTRTALSVVTWNSKGKT POLS_SINDO 227 0 -
VAIVLGGADEGTRTALSVVTWNSKGKT Q88432 227 0 -
VAIVLGGADEGTRTALSVVTWNSKGKT Q88430 227 0 -
VAIVLGGADEGTRTALSVVTWNSKGKT POLS_SINDV 227 0 -
VAIVLGGADEGARTALSVVTWNSKGKT P89913 229 0 -
VAIVLGGANEVPGTALSVVTWNKKGAA Q86925 230 0 -