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PR00756

Identifier
ALADIPTASE  [View Relations]  [View Alignment]  
Accession
PR00756
No. of Motifs
5
Creation Date
18-JUN-1997  (UPDATE 28-JUL-1999)
Title
Membrane alanyl dipeptidase (M1) family signature
Database References

PROSITE; PS00142 ZINC_PROTEASE
BLOCKS; BL00142
INTERPRO; IPR001930
Literature References
1. RAWLINGS, N.D. AND BARRETT, A.J.
Evolutionary families of metallopeptidases.
METHODS ENZYMOL. 248 183-228 (1995).
 
2. HAEGGSTROM, J.Z., WETTERHOLM, A., SHAPIRO, R., VALLEE, B.L.
AND SAMUELSSON, B.
Leukotriene A4 hydrolase: a zinc metalloenzyme.
BIOCHEM.BIOPHYS.RES.COMMUN. 172 965-970 (1990).

Documentation
Metalloproteases are the most diverse of the four main types of protease,
with more than 30 families identified to date [1]. Of these, around
half contain the HEXXH motif, which has been shown in crystallographic
studies to form part of the metal-binding site [1]. The HEXXH motif is 
relatively common, but can be more stringently defined for metallo-
proteases as abXHEbbHbc, where a is most often valine or threonine and 
forms part of the S1' subsite in thermolysin and neprilysin, b is an
uncharged residue, and c a hydrophobic residue. Proline is never found
in this site, possibly because it would break the helical structure 
adopted by this motif in metalloproteases [1].
 
Metalloproteases can be split into five groups on the basis of their metal-
binding residues: the first three contain the HEXXH motif, the other two
do not [1]. In the first group, a glutamic acid completes the active site -
these are termed HEXXH+E: all families in this group show some sequence
relationship and have been assigned to clan MA [1]. The second group, which
have a third histidine as the extra metal-binding residue, are termed
HEXXH+H and are grouped into clan MB on the basis of their inter-relation-
ship[1]. In the third group, the additional metal-binding residues are
unidentified. The fourth group is diverse - the metal-binding residues are
known but do not form the HEXXH motif. And the fifth group comprises the
remaining families where the metal-binding residues are as yet unknown [1].
 
The membrane alanyl aminopeptidase family (M1) is part of the HEXXH+E
group; it consists entirely of aminopeptidases, spread across a wide
variety of species [1]. The enzymes are varied in specificity, removing
N-terminal neutral, acidic and basic residues; one family member (leuko-
triene-A4 hydrolase) is known to hydrolyse the epoxide leukotriene-A4
to form an inflammatory mediator [1]. This hydrolase has been shown to
have aminopeptidase activity [2], and the zinc ligands of the M1 family
were identified by site-directed mutagenesis on this enzyme [1].
 
ALADIPTASE is a 5-element fingerprint that provides a signature for the
membrane alanyl dipeptidase (M1) family of metallopeptidases. The
fingerprint was derived from an initial alignment of 12 sequences: the
motifs were drawn from conserved regions within the central portion of
the alignment - motif 4 includes the region encoded by PROSITE pattern
ZINC_PROTEASE (PS00142), which contains the HEXXH motif, the 2 histidines
of which are zinc ligands and the glutamate of which is the catalytic
residue; motif 5 also contains a conserved glutamate, which provides the
third zinc ligand. Three iterations on OWL29.3 were required to reach
convergence, at which point a true set comprising 51 sequences was
identified. Four partial matches were also found: D909165 is a protein from
Synechocystis that fails to make significant matches with motifs 2 and 3;
and SSAPN, I57748 and AMPE_RAT are fragments that match only 2 motifs.
 
An update on SPTR37_9f identified a true set of 56 sequences, and 2
partial matches.
Summary Information
  56 codes involving  5 elements
0 codes involving 4 elements
1 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
55656565656
400000
310011
210001
12345
True Positives
AAP1_YEAST    AMPB_RAT      AMPE_HUMAN    AMPE_MOUSE    
AMPM_HELVI AMPN_ECOLI AMPN_FELCA AMPN_HAECO
AMPN_HAEIN AMPN_HUMAN AMPN_LACDL AMPN_LACHE
AMPN_LACLA AMPN_LACLC AMPN_MANSE AMPN_MOUSE
AMPN_PIG AMPN_PLUXY AMPN_RABIT AMPN_RAT
AMPN_STRLI APE2_YEAST LKHA_CAVPO LKHA_HUMAN
LKHA_MOUSE LKHA_RAT LKHA_YEAST O00769
O16851 O17484 O17485 O44183
O44969 O46156 O53194 O57579
O62582 O76151 O76803 O93268
P74527 P95928 P97629 PSA_HUMAN
PSA_MOUSE Q10836 Q11009 Q15145
Q20627 Q21673 Q22317 Q22433
Q22530 Q22531 Q95334 YIN7_YEAST
True Positive Partials
Codes involving 3 elements
O69971
Codes involving 2 elements
T2D2_DROME
Sequence Titles
AAP1_YEAST  ALANINE/ARGININE AMINOPEPTIDASE (EC 3.4.11.-) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). 
AMPB_RAT AMINOPEPTIDASE B (EC 3.4.11.6) (ARGINYL AMINOPEPTIDASE) (ARGININE AMINOPEPTIDASE) (CYTOSOL AMINOPEPTIDASE IV) (AP-B) - RATTUS NORVEGICUS (RAT).
AMPE_HUMAN GLUTAMYL AMINOPEPTIDASE (EC 3.4.11.7) (EAP) (AMINOPEPTIDASE A) (APA) (DIFFERENTIATION ANTIGEN GP160) - HOMO SAPIENS (HUMAN).
AMPE_MOUSE GLUTAMYL AMINOPEPTIDASE (EC 3.4.11.7) (EAP) (AMINOPEPTIDASE A) (APA) (BP-1/6C3 ANTIGEN) - MUS MUSCULUS (MOUSE).
AMPM_HELVI MEMBRANE ALANYL AMINOPEPTIDASE PRECURSOR (EC 3.4.11.-) (AMINOPEPTIDASE N-LIKE PROTEIN) (CRYIA(C) RECEPTOR) (BTBP1) - HELIOTHIS VIRESCENS (NOCTUID MOTH) (OWLET MOTH).
AMPN_ECOLI AMINOPEPTIDASE N (EC 3.4.11.2) (ALPHA-AMINOACYLPEPTIDE HYDROLASE) - ESCHERICHIA COLI.
AMPN_FELCA AMINOPEPTIDASE N (EC 3.4.11.2) (MICROSOMAL AMINOPEPTIDASE) (CD13) - FELIS SILVESTRIS CATUS (CAT).
AMPN_HAECO AMINOPEPTIDASE N (EC 3.4.11.2) (MICROSOMAL AMINOPEPTIDASE) (MEMBRANE GLYCOPROTEIN H11) - HAEMONCHUS CONTORTUS.
AMPN_HAEIN AMINOPEPTIDASE N (EC 3.4.11.2) (ALPHA-AMINOACYLPEPTIDE HYDROLASE) - HAEMOPHILUS INFLUENZAE.
AMPN_HUMAN AMINOPEPTIDASE N (EC 3.4.11.2) (MICROSOMAL AMINOPEPTIDASE) (GP150) (MYELOID PLASMA MEMBRANE GLYCOPROTEIN CD13) - HOMO SAPIENS (HUMAN).
AMPN_LACDL AMINOPEPTIDASE N (EC 3.4.11.2) (LYSYL AMINOPEPTIDASE) (LYS-AP) (ALANINE AMINOPEPTIDASE) - LACTOBACILLUS DELBRUECKII (SUBSP. LACTIS).
AMPN_LACHE AMINOPEPTIDASE N (EC 3.4.11.2) (LYSYL AMINOPEPTIDASE) (LYS-AP) (ALANINE AMINOPEPTIDASE) - LACTOBACILLUS HELVETICUS.
AMPN_LACLA AMINOPEPTIDASE N (EC 3.4.11.2) (LYSYL AMINOPEPTIDASE) (LYS-AP) (ALANINE AMINOPEPTIDASE) - LACTOCOCCUS LACTIS (SUBSP. LACTIS) (STREPTOCOCCUS LACTIS).
AMPN_LACLC AMINOPEPTIDASE N (EC 3.4.11.2) (LYSYL AMINOPEPTIDASE) (LYS-AP) (ALANINE AMINOPEPTIDASE) - LACTOCOCCUS LACTIS (SUBSP. CREMORIS) (STREPTOCOCCUS CREMORIS).
AMPN_MANSE AMINOPEPTIDASE N (EC 3.4.11.2) (MICROSOMAL AMINOPEPTIDASE) - MANDUCA SEXTA (TOBACCO HAWKMOTH) (TOBACCO HORNWORM).
AMPN_MOUSE AMINOPEPTIDASE N (EC 3.4.11.2) (MICROSOMAL AMINOPEPTIDASE) (CD13) (P161 MEMBRANE PROTEIN) - MUS MUSCULUS (MOUSE).
AMPN_PIG AMINOPEPTIDASE N (EC 3.4.11.2) (MICROSOMAL AMINOPEPTIDASE) (GP 130) - SUS SCROFA (PIG).
AMPN_PLUXY AMINOPEPTIDASE N (EC 3.4.11.2) (MICROSOMAL AMINOPEPTIDASE) - PLUTELLA XYLOSTELLA (DIAMONDBACK MOTH).
AMPN_RABIT AMINOPEPTIDASE N (EC 3.4.11.2) (MICROSOMAL AMINOPEPTIDASE) (LEUKEMIA ANTIGEN CD13) - ORYCTOLAGUS CUNICULUS (RABBIT).
AMPN_RAT AMINOPEPTIDASE N (EC 3.4.11.2) (MICROSOMAL AMINOPEPTIDASE) - RATTUS NORVEGICUS (RAT).
AMPN_STRLI AMINOPEPTIDASE N (EC 3.4.11.2) (LYSYL AMINOPEPTIDASE) (LYS-AP) (ALANINE AMINOPEPTIDASE) - STREPTOMYCES LIVIDANS.
APE2_YEAST AMINOPEPTIDASE II (EC 3.4.11.-) (YSCII) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
LKHA_CAVPO LEUKOTRIENE A-4 HYDROLASE (EC 3.3.2.6) (LTA-4 HYDROLASE) (LEUKOTRIENE A(4) HYDROLASE) - CAVIA PORCELLUS (GUINEA PIG).
LKHA_HUMAN LEUKOTRIENE A-4 HYDROLASE (EC 3.3.2.6) (LTA-4 HYDROLASE) (LEUKOTRIENE A(4) HYDROLASE) - HOMO SAPIENS (HUMAN).
LKHA_MOUSE LEUKOTRIENE A-4 HYDROLASE (EC 3.3.2.6) (LTA-4 HYDROLASE) (LEUKOTRIENE A(4) HYDROLASE) - MUS MUSCULUS (MOUSE).
LKHA_RAT LEUKOTRIENE A-4 HYDROLASE (EC 3.3.2.6) (LTA-4 HYDROLASE) (LEUKOTRIENE A(4) HYDROLASE) - RATTUS NORVEGICUS (RAT).
LKHA_YEAST PROBABLE LEUKOTRIENE A-4 HYDROLASE (EC 3.3.2.6) (LTA-4 HYDROLASE) (LEUKOTRIENE A(4) HYDROLASE) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
O00769 OXYTOCINASE (EC 3.4.11.3) (CYSTINYL AMINOPEPTIDASE) - HOMO SAPIENS (HUMAN).
O16851 AMINOPEPTIDASE N - PLUTELLA XYLOSTELLA (DIAMONDBACK MOTH).
O17484 AMINOPEPTIDASE - PLODIA INTERPUNCTELLA (INDIAN MEAL MOTH).
O17485 AMINOPEPTIDASE - PLODIA INTERPUNCTELLA (INDIAN MEAL MOTH).
O44183 ZC416.6 PROTEIN - CAENORHABDITIS ELEGANS.
O44969 C42C1.11 PROTEIN - CAENORHABDITIS ELEGANS.
O46156 AMINOPEPTIDASE N PRECURSOR (EC 3.4.11.2) (MEMBRANE ALANINE AMINOPEPTIDASE) (MICROSOMAL AMINOPEPTIDASE) (AMINOPEPTIDASE M) (PARTICLE-BOUND AMINOPEPTIDASE) (AMINO-OLIGOPEPTIDASE) (MEMBRANE AMINOPEPTIDASE I) (PEPTIDASE E) - PLUTELLA XYLOSTELLA (DIAMONDBACK MOTH).
O53194 AMINOPEPTIDASE - MYCOBACTERIUM TUBERCULOSIS.
O57579 AMINOPEPTIDASE EY - GALLUS GALLUS (CHICKEN).
O62582 AMINOPEPTIDASE (EC 3.4.11.7) - ENCEPHALITOZOON CUNICULI.
O76151 AMINOPEPTIDASE N - BOMBYX MORI (SILK MOTH).
O76803 AMINOPEPTIDASE N - BOMBYX MORI (SILK MOTH).
O93268 AMINOPEPTIDASE N (EC 3.4.11.2) - PLEURONECTES AMERICANUS.
P74527 AMINOPEPTIDASE - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
P95928 AMINOPEPTIDASE - SULFOLOBUS SOLFATARICUS.
P97629 INSULIN-REGULATED MEMBRANE AMINOPEPTIDASE IRAP - RATTUS NORVEGICUS (RAT).
PSA_HUMAN PUROMYCIN-SENSITIVE AMINOPEPTIDASE (EC 3.4.11.-) (PSA) - HOMO SAPIENS (HUMAN).
PSA_MOUSE PUROMYCIN-SENSITIVE AMINOPEPTIDASE (EC 3.4.11.-) (PSA) - MUS MUSCULUS (MOUSE).
Q10836 THYROTROPIN-RELEASING HORMONE DEGRADING ENZYME - RATTUS NORVEGICUS (RAT).
Q11009 INSULIN-REGULATED MEMBRANE AMINOPEPTIDASE VP165 (EC. 3.4.11.-) (VESICLE PROTEIN 165) (GP160) - RATTUS NORVEGICUS (RAT).
Q15145 PLACENTAL LEUCINE AMINOPEPTIDASE - HOMO SAPIENS (HUMAN).
Q20627 CODED FOR BY C. ELEGANS CDNA YK2G1.3 - CAENORHABDITIS ELEGANS.
Q21673 R03G8.4 PROTEIN - CAENORHABDITIS ELEGANS.
Q22317 T07F10.1 PROTEIN - CAENORHABDITIS ELEGANS.
Q22433 SIMILAR TO ZINC METALLOPROTEASE - CAENORHABDITIS ELEGANS.
Q22530 T16G12.2 PROTEIN - CAENORHABDITIS ELEGANS.
Q22531 T16G12.1 PROTEIN - CAENORHABDITIS ELEGANS.
Q95334 AMINOPEPTIDASE A (EC 3.4.11.7) (GLUTAMYL AMINOPEPTIDASE) (ASPARTATE AMINOPEPTIDASE) (ANGIOTENSINASE A) (GLUTAMYL PEPTIDASE) (MEMBRANE AMINOPEPTIDASE II) - SUS SCROFA (PIG).
YIN7_YEAST HYPOTHETICAL ZINC AMINOPEPTIDASE YIL137C (EC 3.4.11.-) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).

O69971 ZINC METALLOPROTEASE - STREPTOMYCES COELICOLOR.

T2D2_DROME TRANSCRIPTION INITIATION FACTOR TFIID 150 KD SUBUNIT (TAFII-150) (TAFII150) - DROSOPHILA MELANOGASTER (FRUIT FLY).
Scan History
OWL29_3    3  120  NSINGLE    
SPTR37_9f 3 200 NSINGLE
Initial Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
RKSFPCFDEPAMKATF AMPN_PIG 212 212 -
RRAFPCFDEPNLKATF AAP1_YEAST 137 137 -
RRAFPCFDEPNLKASF APE2_YEAST 142 142 -
RKSFPCFDEPNKKATY AMPE_HUMAN 228 228 -
REAFPCVDEPEAKATF AMPN_LACDL 124 124 -
RRVFASFEQPDLKATF AMPN_STRLI 135 135 -
RAFLPCQDTPSVKLTY LKHA_CAVPO 141 141 -
RAILPCQDTPSVKLTY LKHA_HUMAN 141 141 -
RSLFPCFDTPSVKSTF LKHA_YEAST 191 191 -
SNIFPCIDEPSNKSTF YIN7_YEAST 160 160 -
RQITYMLDRPDVLARY AMPN_HAEIN 127 127 -
RHITYYLDRPDVLARF AMPN_ECOLI 125 125 -

Motif 2 width=16
Element Seqn Id St Int Rpt
FETTPVMSTYLLAYIV AMPN_PIG 263 35 -
FNTTPKMSTYLVAFIV AAP1_YEAST 184 31 -
FNTTPKMSTYLVAFIV APE2_YEAST 189 31 -
FEKSVPMSTYLVCFAV AMPE_HUMAN 276 32 -
FKETVRMSSYLVAFAF AMPN_LACDL 169 29 -
FEPTPRISSYVTALIV AMPN_STRLI 178 27 -
FSQKVPIPCYLIALVV LKHA_CAVPO 191 34 -
FIQKVPIPCYLIALVV LKHA_HUMAN 191 34 -
FEQKVPIPAYLIGIAS LKHA_YEAST 235 28 -
FAKTPLMTTSVFGFSI YIN7_YEAST 209 33 -
WNDPFPKPSYLFALVA AMPN_HAEIN 177 34 -
WQDPFPKPCYLFALVA AMPN_ECOLI 175 34 -

Motif 3 width=11
Element Seqn Id St Int Rpt
FNAGAMENWGL AMPN_PIG 343 64 -
FSAGAMENWGL AAP1_YEAST 261 61 -
FSAGAMENWGL APE2_YEAST 266 61 -
FGTGAMENWGL AMPE_HUMAN 354 62 -
FSAGAMENWGL AMPN_LACDL 248 63 -
FNAGAMENAGA AMPN_STRLI 261 67 -
FSYGGMENPCL LKHA_CAVPO 265 58 -
FPYGGMENPCL LKHA_HUMAN 265 58 -
YPYGGMESPNM LKHA_YEAST 310 59 -
LSDMAMENFGM YIN7_YEAST 290 65 -
FNMGAMENKGL AMPN_HAEIN 259 66 -
FNMGAMENKGL AMPN_ECOLI 257 66 -

Motif 4 width=16
Element Seqn Id St Int Rpt
VIAHELAHQWFGNLVT AMPN_PIG 379 25 -
VIQHELAHQWFGNLVT AAP1_YEAST 297 25 -
VVQHELAHQWFGNLVT APE2_YEAST 302 25 -
VVAHELVHQWFGNIVT AMPE_HUMAN 390 25 -
VVTHELAHQWFGDLVT AMPN_LACDL 284 25 -
TILHELAHMWFGDLVT AMPN_STRLI 295 23 -
VIAHEISHTWTGNLVT LKHA_CAVPO 292 16 -
VIAHEISHSWTGNLVT LKHA_HUMAN 292 16 -
VIAHELAHSWSGNLVT LKHA_YEAST 337 16 -
LIVHELVHQWMGNYIS YIN7_YEAST 327 26 -
VIAHEYFHNWTGNRVT AMPN_HAEIN 295 25 -
VIGHEYFHNWTGNRVT AMPN_ECOLI 293 25 -

Motif 5 width=13
Element Seqn Id St Int Rpt
WNDLWLNEGFASY AMPN_PIG 398 3 -
WEGLWLNEGFATW AAP1_YEAST 316 3 -
WEGLWLNEGFATW APE2_YEAST 321 3 -
WEDLWLNEGFASF AMPE_HUMAN 409 3 -
WDNLWLNESFANM AMPN_LACDL 303 3 -
WNDLWLNESFATY AMPN_STRLI 314 3 -
WDHFWLNEGHTVY LKHA_CAVPO 311 3 -
WDHFWLNEGHTVY LKHA_HUMAN 311 3 -
WNHFWLNEGWTVY LKHA_YEAST 356 3 -
WESLWFNESFATW YIN7_YEAST 346 3 -
WFQLSLKEGLTVF AMPN_HAEIN 314 3 -
WFQLSLKEGLTVF AMPN_ECOLI 312 3 -
Final Motifs
Motif 1  width=16
Element Seqn Id St Int Rpt
RKSFPCFDEPAMKATF AMPN_PIG 212 212 -
RKSFPCFDEPAMKATF AMPN_FELCA 216 216 -
RKSFPCFDEPAMKATF AMPN_RABIT 214 214 -
RKSFPCFDEPAMKAEF AMPN_HUMAN 217 217 -
RKAFPCFDEPAMKAVF O57579 217 217 -
RKAFPCFDEPAMKATF O93268 226 226 -
RKSFPCFDEPAMKASF AMPN_RAT 217 217 -
RKSFPCFDEPAMKAMF AMPN_MOUSE 217 217 -
RSAFPCFDEPAFKATF Q15145 219 219 -
RSAFPCFDEPAFKATF Q11009 299 299 -
RSAFPCFDEPAFKATF P97629 300 300 -
RSAFPCFDEPAFKATF O00769 300 300 -
RRAFPCFDEPNLKATF AAP1_YEAST 137 137 -
RRAFPCFDEPNLKASF APE2_YEAST 142 142 -
RRAFPCWDEPAIKATF PSA_HUMAN 185 185 -
RRAFPCWDEPAIKATF PSA_MOUSE 186 186 -
RQAFPCYDEPGFKATF O76803 189 189 -
REAFPCVDEPEAKATF AMPN_LACLA 127 127 -
RRAFPCYDEPSFKATF O17484 205 205 -
RRAFPCYDEPSFKATF O17485 205 205 -
RYAFPCFDEPIYKATF Q20627 147 147 -
RKAFPCYDEPGFKALF O16851 193 193 -
RRMVPCFDEPAYKATW Q22317 231 231 -
RRAFPCFDQPDMKATF O62582 154 154 -
RQAFPCVDEPEAKATF AMPN_LACHE 125 125 -
RYAFPCYDEPGFKAKF AMPM_HELVI 201 201 -
RKSFPCFDEPNKKATY AMPE_HUMAN 228 228 -
RKSFPCFDEPNKKATY Q95334 218 218 -
REAFPCVDEPEAKATF AMPN_LACDL 124 124 -
RQAFPSIDEPEAKATF AMPN_LACLC 124 124 -
RRMVPCMDEPKYKANW AMPN_HAECO 212 212 -
RKSFPCFDEPNKKSTY AMPE_MOUSE 220 220 -
RKVFPSLDEPSYKAKF Q22530 225 225 -
RFMVPCFDEPEFKAIW Q21673 169 169 -
RDFIPCFDHPAMKARF P95928 111 111 -
RRAFPCYDEPALKAVF AMPN_PLUXY 174 174 -
RRAFPCYDEPALKAVF AMPN_MANSE 170 170 -
RRAFPCYDEPAIKAIF O76151 170 170 -
KRMFACFDQPDLKATF O53194 136 136 -
RKAFPCFDEPIYKATF Q10836 274 274 -
RSLLPCWDEPSYKGQF Q22531 233 233 -
RRVFASFEQPDLKATF AMPN_STRLI 135 135 -
RQLFPSFDEPGFKSTF O46156 190 190 -
RSIVPCMDTPSVKSTY O44969 344 344 -
RAFFPCFDTPAVKCTY AMPB_RAT 175 175 -
RAFLPCQDTPSVKLTY LKHA_CAVPO 141 141 -
RAILPCQDTPSVKLTY LKHA_MOUSE 141 141 -
RAILPCQDTPSVKLTY LKHA_HUMAN 141 141 -
RSIVPCMDTPSVKSTY O44183 110 110 -
RSLFPCFDTPSVKSTF LKHA_YEAST 191 191 -
RAILPCQDTSVKLTYT LKHA_RAT 141 141 -
RRLFPCIDHPAVKALF Q22433 59 59 -
RYWFPCFDYPGQLATS P74527 149 149 -
SNIFPCIDEPSNKSTF YIN7_YEAST 160 160 -
RQITYMLDRPDVLARY AMPN_HAEIN 127 127 -
RHITYYLDRPDVLARF AMPN_ECOLI 125 125 -

Motif 2 width=16
Element Seqn Id St Int Rpt
FETTPVMSTYLLAYIV AMPN_PIG 263 35 -
FETTPIMSTYLLAYIV AMPN_FELCA 267 35 -
FHTTPKMSTYLLAYIV AMPN_RABIT 264 34 -
FHTTPKMSTYLLAFIV AMPN_HUMAN 268 35 -
FDPTPRMSTYLLAFIV O57579 268 35 -
FEQTEKMSTYLLAFIV O93268 277 35 -
FHPTPKMSTYLLAYIV AMPN_RAT 267 34 -
FHSTPKMSTYLLAYIV AMPN_MOUSE 267 34 -
FSESVKMSTYLVAFIV Q15145 267 32 -
FSESVKMSTYLVAFIV Q11009 347 32 -
FSESVKMSTYLVAFIV P97629 348 32 -
FSESVKMSTYLVAFIV O00769 348 32 -
FNTTPKMSTYLVAFIV AAP1_YEAST 184 31 -
FNTTPKMSTYLVAFIV APE2_YEAST 189 31 -
FARTPVMSTYLVAFVV PSA_HUMAN 235 34 -
FARTPVMSTYLVAFVV PSA_MOUSE 236 34 -
FWTTPVTSTYLLAFIV O76803 238 33 -
FETTPRMSTYLLAFGF AMPN_LACLA 176 33 -
FYRTPIMSTYLLAIIV O17484 256 35 -
FYRTPIMSTYLLAIIV O17485 256 35 -
FATSPKMSSYLVAFAV Q20627 196 33 -
FYTTPLTSSYLVAFIV O16851 242 33 -
FKPTPRMSSYLLAIFI Q22317 279 32 -
FEETCKMSTYLVAFVV O62582 203 33 -
FEETVRMSSYLVAFAF AMPN_LACHE 171 30 -
YHTTPTMSTYLLALIV AMPM_HELVI 250 33 -
FEKSVPMSTYLVCFAV AMPE_HUMAN 276 32 -
FQKSVPMSTYLVCFAV Q95334 266 32 -
FKETVRMSSYLVAFAF AMPN_LACDL 169 29 -
FERTVKMSSYLLAFVF AMPN_LACLC 169 29 -
FLTTPRMSSYLLAVMV AMPN_HAECO 261 33 -
FVKSVPMSTYLVCFAV AMPE_MOUSE 268 32 -
FPQTPKMSSYLIAFAV Q22530 273 32 -
FESTLKMSSYILAIFV Q21673 217 32 -
FDETPKMSTYLLYLGI P95928 158 31 -
FQDTLVMSSYLLAYLV AMPN_PLUXY 225 35 -
FEDTLVMSTYLIAYLV AMPN_MANSE 221 35 -
FEDTLVMSTYLLAYLV O76151 221 35 -
FATTPRMSTYLVALIA O53194 179 27 -
FSQTPLMSTYYLAWAI Q10836 322 32 -
FATTNQMSTYLLALCV Q22531 281 32 -
FEPTPRISSYVTALIV AMPN_STRLI 178 27 -
FYTTPRMSAYLVTIHI O46156 239 33 -
FKQPVSIPSYLLAIVV O44969 393 33 -
FQMSQPIPSYLIALAI AMPB_RAT 219 28 -
FSQKVPIPCYLIALVV LKHA_CAVPO 191 34 -
FNQRVPIPCYLIALVV LKHA_MOUSE 191 34 -
FIQKVPIPCYLIALVV LKHA_HUMAN 191 34 -
YKQPVAIPSYLIAIVV O44183 157 31 -
FEQKVPIPAYLIGIAS LKHA_YEAST 235 28 -
FNQRVPIPCYLIALVV LKHA_RAT 190 33 -
FQATPLLPAYLVAFSV Q22433 107 32 -
WSQSQIHPTYLMTLAI P74527 196 31 -
FAKTPLMTTSVFGFSI YIN7_YEAST 209 33 -
WNDPFPKPSYLFALVA AMPN_HAEIN 177 34 -
WQDPFPKPCYLFALVA AMPN_ECOLI 175 34 -

Motif 3 width=11
Element Seqn Id St Int Rpt
FNAGAMENWGL AMPN_PIG 343 64 -
FNAGAMENWGL AMPN_FELCA 347 64 -
FNAGAMENWGL AMPN_RABIT 344 64 -
FNAGAMENWGL AMPN_HUMAN 348 64 -
FNAGAMENWGL O57579 347 63 -
FNAGAMENWGL O93268 356 63 -
FNAGAMENWGL AMPN_RAT 347 64 -
FNAGAMENWGL AMPN_MOUSE 347 64 -
FEAGAMENWGL Q15145 344 61 -
FEAGAMENWGL Q11009 424 61 -
FEAGAMENWGL P97629 425 61 -
FEAGAMENWGL O00769 425 61 -
FSAGAMENWGL AAP1_YEAST 261 61 -
FSAGAMENWGL APE2_YEAST 266 61 -
FAAGAMENWGL PSA_HUMAN 313 62 -
FAAGAMENWGL PSA_MOUSE 314 62 -
FSAGAMENWGL O76803 320 66 -
FSAGAMENWGL AMPN_LACLA 255 63 -
FGAGAMENWGL O17484 341 69 -
FGAGAMENWGL O17485 341 69 -
FSMGAMENWGL Q20627 274 62 -
FSAGAMENWGL O16851 324 66 -
FSAGAMENWGL Q22317 357 62 -
FSSGAMENWGL O62582 286 67 -
FSAGAMENWGL AMPN_LACHE 250 63 -
FGAGAMENWGL AMPM_HELVI 335 69 -
FGTGAMENWGL AMPE_HUMAN 354 62 -
FGTGAMENWGL Q95334 344 62 -
FSAGAMENWGL AMPN_LACDL 248 63 -
FSAGAMENWGC AMPN_LACLC 248 63 -
FSAGAMENWGL AMPN_HAECO 339 62 -
FGTGAMENWGL AMPE_MOUSE 346 62 -
FLAGAMENWGL Q22530 351 62 -
FRYGAMENWGL Q21673 295 62 -
FAYGAMENWGA P95928 235 61 -
FAAGAMENWGL AMPN_PLUXY 305 64 -
FAAGAMENWGL AMPN_MANSE 301 64 -
FAAGAMENWGL O76151 301 64 -
FNAGAMENAGA O53194 262 67 -
HPYAAMENWGL Q10836 402 64 -
MNAGAMENWGL Q22531 361 64 -
FNAGAMENAGA AMPN_STRLI 261 67 -
WASGATENWGL O46156 322 67 -
FPFGGMENPCL O44969 467 58 -
FPFGGMENPCL AMPB_RAT 293 58 -
FSYGGMENPCL LKHA_CAVPO 265 58 -
FPYGGMENPCL LKHA_MOUSE 265 58 -
FPYGGMENPCL LKHA_HUMAN 265 58 -
FPFGGMENPCL O44183 231 58 -
YPYGGMESPNM LKHA_YEAST 310 59 -
FPYGGMENPCL LKHA_RAT 264 58 -
EYDGGMENWGH Q22433 184 61 -
FIFGGMENTST P74527 273 61 -
LSDMAMENFGM YIN7_YEAST 290 65 -
FNMGAMENKGL AMPN_HAEIN 259 66 -
FNMGAMENKGL AMPN_ECOLI 257 66 -

Motif 4 width=16
Element Seqn Id St Int Rpt
VIAHELAHQWFGNLVT AMPN_PIG 379 25 -
VIAHELAHQWFGNLVT AMPN_FELCA 383 25 -
VVAHELAHQWFGNLVT AMPN_RABIT 380 25 -
VIAHELAHQWFGNLVT AMPN_HUMAN 384 25 -
VIAHELAHQWFGNLVT O57579 383 25 -
IIAHELAHMWFGNLVT O93268 392 25 -
VIAHELAHQWFGNLVT AMPN_RAT 383 25 -
VIAHELAHQWFGNLVT AMPN_MOUSE 383 25 -
IIAHELAHQWFGNLVT Q15145 380 25 -
IIAHELAHQWFGNLVT Q11009 460 25 -
IIAHELAHQWFGNLVT P97629 461 25 -
IIAHELAHQWFGNLVT O00769 461 25 -
VIQHELAHQWFGNLVT AAP1_YEAST 297 25 -
VVQHELAHQWFGNLVT APE2_YEAST 302 25 -
VVGHELAHQWFGNLVT PSA_HUMAN 349 25 -
VVGHELAHQWFGNLVT PSA_MOUSE 350 25 -
IVAHEIAHMWFGNLVT O76803 356 25 -
VVAHELAHQWFGNLVT AMPN_LACLA 290 24 -
ILSHEIAHMWFGNLVT O17484 377 25 -
ILSHEIAHMWFGNLVT O17485 377 25 -
VVAHELAHLWFGNLVT Q20627 310 25 -
IVAHEIAHMWFGNLVT O16851 360 25 -
VIAHELAHQWFGNLVT Q22317 393 25 -
TVCHELGHMWFGNLVT O62582 322 25 -
VITHELAHQWFGDLVT AMPN_LACHE 286 25 -
ILSHEIAHMWFGNLVT AMPM_HELVI 371 25 -
VVAHELVHQWFGNIVT AMPE_HUMAN 390 25 -
VVAHELVHQWFGNIVT Q95334 380 25 -
VVTHELAHQWFGDLVT AMPN_LACDL 284 25 -
VIAHELAHQWFGDLVT AMPN_LACLC 284 25 -
IVAHELAHQWFGDLVT AMPN_HAECO 375 25 -
VVAHELVHQWFGNTVT AMPE_MOUSE 382 25 -
VMCHELAHQWFGDLVT Q22530 387 25 -
VVAHEIAHQWFGNLVT Q21673 328 22 -
VVAHELAHQWFGNLVT P95928 270 24 -
IISHENTHQWFGNEVG AMPN_PLUXY 341 25 -
IICHENTHMWFGNEVG AMPN_MANSE 337 25 -
IICHENVHMWYGNEVG O76151 337 25 -
TVLHEMAHMWFGDLVT O53194 296 23 -
VIVHEICHQWFGDLVT Q10836 438 25 -
TTAHEVVHQWFGDIVT Q22531 397 25 -
TILHELAHMWFGDLVT AMPN_STRLI 295 23 -
ITAHELGHKWFGNLVT O46156 358 25 -
VIAHEISHSWTGNLVT O44969 494 16 -
VIIHEISHSWFGNLVT AMPB_RAT 320 16 -
VIAHEISHTWTGNLVT LKHA_CAVPO 292 16 -
VIAHEISHSWTGNLVT LKHA_MOUSE 292 16 -
VIAHEISHSWTGNLVT LKHA_HUMAN 292 16 -
VIAHEIAHSWSGNLVT O44183 258 16 -
VIAHELAHSWSGNLVT LKHA_YEAST 337 16 -
VIAHEISHSWTGNLVT LKHA_RAT 291 16 -
LIAHEIAHHWIGNRAT Q22433 213 18 -
LVAHELAHQWFGDLVV P74527 306 22 -
LIVHELVHQWMGNYIS YIN7_YEAST 327 26 -
VIAHEYFHNWTGNRVT AMPN_HAEIN 295 25 -
VIGHEYFHNWTGNRVT AMPN_ECOLI 293 25 -

Motif 5 width=13
Element Seqn Id St Int Rpt
WNDLWLNEGFASY AMPN_PIG 398 3 -
WNDLWLNEGFASY AMPN_FELCA 402 3 -
WNDLWLNEGFASY AMPN_RABIT 399 3 -
WNDLWLNEGFASY AMPN_HUMAN 403 3 -
WNDLWLNEGFASY O57579 402 3 -
WNDLWLNEGFASY O93268 411 3 -
WNDLWLNEGFASY AMPN_RAT 402 3 -
WNDLWLNEGFASY AMPN_MOUSE 402 3 -
WNDLWLNEGFATF Q15145 399 3 -
WNDLWLNEGFATF Q11009 479 3 -
WNDLWLNEGFATF P97629 480 3 -
WNDLWLNEGFATF O00769 480 3 -
WEGLWLNEGFATW AAP1_YEAST 316 3 -
WEGLWLNEGFATW APE2_YEAST 321 3 -
WTHLWLNEGFASW PSA_HUMAN 368 3 -
WTHLWLNEGFASW PSA_MOUSE 369 3 -
WDNLWLNEGFARF O76803 375 3 -
WDDLWLNESFANM AMPN_LACLA 309 3 -
WDVLWLNEGFAKY O17484 396 3 -
WDVLWLNEGFAKY O17485 396 3 -
WTDLWLKEGFASF Q20627 329 3 -
WDNLWLNEGFARY O16851 379 3 -
WNDLWLNEGFATL Q22317 412 3 -
WDDLWLNEGFATW O62582 341 3 -
WDNLWLNESFANM AMPN_LACHE 305 3 -
WDVLWLNEGFARY AMPM_HELVI 390 3 -
WEDLWLNEGFASF AMPE_HUMAN 409 3 -
WEDLWLNEGFASF Q95334 399 3 -
WDNLWLNESFANM AMPN_LACDL 303 3 -
WDDLWLNESFANN AMPN_LACLC 303 3 -
WDNLWLNEGFARF AMPN_HAECO 394 3 -
WDDLWLNEGFASF AMPE_MOUSE 401 3 -
WDDLFLNEGFADY Q22530 406 3 -
WDQLWLNEGFATY Q21673 347 3 -
WDDLWLNESFATF P95928 289 3 -
WTYTWLNEGFANF AMPN_PLUXY 360 3 -
WTYTWLNEGFANF AMPN_MANSE 356 3 -
WTYTWLNEGFATF O76151 356 3 -
WDDLWLNESFATF O53194 315 3 -
WEDVWLKEGFAHY Q10836 457 3 -
WNDIFLNEGFAQY Q22531 416 3 -
WNDLWLNESFATY AMPN_STRLI 314 3 -
WDNVWINEGYASY O46156 377 3 -
WEHFWLNEGFTVF O44969 513 3 -
WGEFWLNEGFTMY AMPB_RAT 339 3 -
WDHFWLNEGHTVY LKHA_CAVPO 311 3 -
WDHFWLNEGHTVY LKHA_MOUSE 311 3 -
WDHFWLNEGHTVY LKHA_HUMAN 311 3 -
WEHFWLNEGFTMF O44183 277 3 -
WNHFWLNEGWTVY LKHA_YEAST 356 3 -
WDHFWLNEGHTVY LKHA_RAT 310 3 -
WNWICLQEDLTDW Q22433 232 3 -
WSHAWLKEGMASY P74527 325 3 -
WESLWFNESFATW YIN7_YEAST 346 3 -
WFQLSLKEGLTVF AMPN_HAEIN 314 3 -
WFQLSLKEGLTVF AMPN_ECOLI 312 3 -