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PR00724

Identifier
CRBOXYPTASEC  [View Relations]  [View Alignment]  
Accession
PR00724
No. of Motifs
4
Creation Date
12-MAR-1995  (UPDATE 07-JUN-1999)
Title
Carboxypeptidase C serine protease (S10) family signature
Database References

PROSITE; PS00131 CARBOXYPEPT_SER_SER; PS00560 CARBOXYPEPT_SER_HIS
BLOCKS; BL00131
INTERPRO; IPR001563
PDB; 1WHT
SCOP; 1WHT
CATH; 1WHT
Literature References
1. RAWLINGS, N.D. AND BARRETT, A.J.
Families of serine peptidases.
METHODS ENZYMOL. 244 19-61 (1994).
 
2. RAWLINGS, N.D AND BARRETT, A.J.
Evolutionary families of peptidases.
BIOCHEM.J. 290 205-218 (1993).

Documentation
Proteolytic enzymes that exploit serine in their catalytic activity are
ubiquitous, being found in viruses, bacteria and eukaryotes [1]. They 
include a wide range of peptidase activity, including exopeptidase, endo-
peptidase, oligopeptidase and omega-peptidase activity. Over 20 families
(denoted S1 - S27) of serine protease have been identified, these being
grouped into 6 clans (SA, SB, SC, SE, SF and SG) on the basis of structural
similarity and other functional evidence [1]. Structures are known for four
of the clans (SA, SB, SC and SE): these appear to be totally unrelated,
suggesting at least four evolutionary origins of serine peptidases and
possibly many more [1].
 
Notwithstanding their different evolutionary origins, there are similarities
in the reaction mechanisms of several peptidases. Chymotrypsin, subtilisin
and carboxypeptidase C clans have a catalytic triad of serine, aspartate and 
histidine in common: serine acts as a nucleophile, aspartate as an
electrophile, and histidine as a base [1]. The geometric orientations of
the catalytic residues are similar between families, despite different 
protein folds [1]. The linear arrangements of the catalytic residues
commonly reflect clan relationships. For example the catalytic triad in 
the chymotrypsin clan (SA) is ordered HDS, but is ordered DHS in the
subtilisin clan (SB) and SDH in the carboxypeptidase clan (SC) [1,2].
 
The carboxypeptidase C family comprises a number of serine carboxy-
peptidases, which are unusual in that their optimium activity occurs in
acidic conditions [1]. They are eukaryotic proteins that are located in the
lysosome in animals and the vacuole in plants and fungi [1]. The mammalian
enzyme is also refered to as `protective protein', as it complexes 
beta-galactosidase and neurominidase in the lysosome, protecting them from
proteolytic degradation. Absence of the enzyme results in the lysosomal
storage disease galactosialidosis [1].
 
All members of the family are synthesised with N-terminal signal peptides,
which is consistent with their lysosomal and vacuolar locations. Each has 
a glutamate immediately preceding the catalyic serine, which is believed
to be responsible for the acidic pH optimum [1]. The 3D structures of a
number of family members are known; they show no fold similarities to
chymotrypsin, subtilisin or D-Ala-D-Ala peptidases [1]. However, there does
appear to be some similarity to the folds of other non-peptidase enzymes,
which fall into the alpha/beta hydrolase fold clan [1].
 
CRBOXYPTASEC is a 4-element fingerprint that provides a signature for the
carboxypeptidase C (S10) family of serine proteases. The fingerprint
was derived from an initial alignment of 16 sequences: the motifs were
largely drawn from conserved regions surrounding the active site - motif 3
includes the region encoded by PROSITE pattern CARBOXYPEPT_SER_SER
(PS00131), which contains the catalytic Ser; and motif 4 spans the region
encoded by PROSITE pattern CARBOXYPEPT_SER_HIS (PS00560), which contains the
catalytic His (the region around the active Asp was not sufficiently well
conserved to be used as a diagnostic motif). Three iterations on OWL29.1
were required to reach convergence, at which point a true set comprising 38
sequences was identified. Two partial matches were also found, A41612 and
VRU49382, both of which are fragments that lack portions of sequence
bearing one or more motifs. 
 
An update on SPTR37_9f identified a true set of 52 sequences.
Summary Information
52 codes involving  4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
452525252
30000
20000
1234
True Positives
CBP1_HORVU    CBP1_ORYSA    CBP2_HORVU    CBP2_WHEAT    
CBP3_HORVU CBP3_ORYSA CBP3_WHEAT CBPX_ARATH
CBPX_ORYSA CBPY_CANAL CBPY_PICPA CBPY_YEAST
CP23_HORVU CPS1_PENJA KEX1_YEAST NF31_NAEFO
O04084 O13849 O14414 O22732
O22803 O23364 O45916 O60123
O60790 O64807 O64808 O64809
O64810 O64811 O65568 O74702
O76725 O81009 O82228 O82229
P93177 P93178 PEPF_ASPNG PEPS_ASPSA
PRTP_HUMAN PRTP_MOUSE Q12569 Q94269
SXA2_SCHPO VCP_AEDAE YBY9_YEAST YSS2_CAEEL
YUA6_CAEEL YUW5_CAEEL YXD2_CAEEL YYP3_CAEEL
Sequence Titles
CBP1_HORVU  SERINE CARBOXYPEPTIDASE I PRECURSOR (EC 3.4.16.5) (CARBOXYPEPTIDASE C) (CP-MI) - HORDEUM VULGARE (BARLEY). 
CBP1_ORYSA SERINE CARBOXYPEPTIDASE I PRECURSOR (EC 3.4.16.5) (CARBOXYPEPTIDASE C) - ORYZA SATIVA (RICE).
CBP2_HORVU SERINE CARBOXYPEPTIDASE II CHAINS A AND B (EC 3.4.16.6) (CARBOXYPEPTIDASE D) (CP-MII) - HORDEUM VULGARE (BARLEY).
CBP2_WHEAT SERINE CARBOXYPEPTIDASE II CHAINS A AND B (EC 3.4.16.6) (CARBOXYPEPTIDASE D) (CPDW-II) (CP-WII) - TRITICUM AESTIVUM (WHEAT).
CBP3_HORVU SERINE CARBOXYPEPTIDASE III PRECURSOR (EC 3.4.16.5) (CP-MIII) - HORDEUM VULGARE (BARLEY).
CBP3_ORYSA SERINE CARBOXYPEPTIDASE III PRECURSOR (EC 3.4.16.5) - ORYZA SATIVA (RICE).
CBP3_WHEAT SERINE CARBOXYPEPTIDASE III PRECURSOR (EC 3.4.16.5) (CP-WIII) - TRITICUM AESTIVUM (WHEAT).
CBPX_ARATH SERINE CARBOXYPEPTIDASE PRECURSOR (EC 3.4.16.-) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
CBPX_ORYSA SERINE CARBOXYPEPTIDASE-LIKE PRECURSOR (EC 3.4.16.-) - ORYZA SATIVA (RICE).
CBPY_CANAL CARBOXYPEPTIDASE Y PRECURSOR (EC 3.4.16.5) (CARBOXYPEPTIDASE YSCY) - CANDIDA ALBICANS (YEAST).
CBPY_PICPA CARBOXYPEPTIDASE Y PRECURSOR (EC 3.4.16.5) (CARBOXYPEPTIDASE YSCY) - PICHIA PASTORIS (YEAST).
CBPY_YEAST CARBOXYPEPTIDASE Y PRECURSOR (EC 3.4.16.5) (CARBOXYPEPTIDASE YSCY) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
CP23_HORVU SERINE CARBOXYPEPTIDASE II-3 PRECURSOR (EC 3.4.16.6) (CP-MII.3) - HORDEUM VULGARE (BARLEY).
CPS1_PENJA CARBOXYPEPTIDASE S1 (EC 3.4.16.6) - PENICILLIUM JANTHINELLUM (PENICILLIUM VITALE).
KEX1_YEAST CARBOXYPEPTIDASE KEX1 PRECURSOR (EC 3.4.16.6) (CARBOXYPEPTIDASE D) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
NF31_NAEFO VIRULENCE-RELATED PROTEIN NF314 (EC 3.4.16.-) - NAEGLERIA FOWLERI.
O04084 SERINE CARBOXYPEPTIDASE ISOLOG - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O13849 CARBOXYPEPTIDASE Y - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O14414 CARBOXYPEPTIDASE Y - PICHIA ANGUSTA (YEAST) (HANSENULA POLYMORPHA).
O22732 SIMILAR TO SERINE CARBOXYPEPTIDASES - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O22803 PUTATIVE SERINE CARBOXYPEPTIDASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O23364 HYDROXYNITRILE LYASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O45916 F22E12.1 PROTEIN - CAENORHABDITIS ELEGANS.
O60123 SERINE CARBOXYPETIDASE FAMILY PROTEIN - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O60790 DJ337O18.2 (LYSOSOMAL PROTECTIVE PROTEIN PRECURSOR (EC 3.4.16.5, CATHEPSIN A, CARBOXYPEPTIDASE C)) - HOMO SAPIENS (HUMAN).
O64807 PUTATIVE SERINE CARBOXYPEPTIDASE I - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O64808 PUTATIVE SERINE CARBOXYPEPTIDASE I - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O64809 PUTATIVE SERINE CARBOXYPEPTIDASE I - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O64810 PUTATIVE SERINE CARBOXYPEPTIDASE I - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O64811 PUTATIVE SERINE CARBOXYPEPTIDASE I - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O65568 SERINE CARBOXYPEPTIDASE II - LIKE PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O74702 CARBOXYPEPTIDASE KEX1 PRECURSOR - PICHIA PASTORIS (YEAST).
O76725 Y40D12A.2 PROTEIN - CAENORHABDITIS ELEGANS.
O81009 PUTATIVE SERINE CARBOXYPEPTIDASE I - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O82228 PUTATIVE SERINE CARBOXYPEPTIDASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O82229 PUTATIVE SERINE CARBOXYPEPTIDASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P93177 SERINE CARBOXYPEPTIDASE II, CP-MII PRECURSOR - HORDEUM VULGARE (BARLEY).
P93178 SERINE CARBOXYPEPTIDASE III, CP-MIII PRECURSOR.
PEPF_ASPNG SERINE-TYPE CARBOXYPEPTIDASE F PRECURSOR (EC 3.4.16.-) (PROTEINASE F) (CPD-II) - ASPERGILLUS NIGER.
PEPS_ASPSA CARBOXYPEPTIDASE CPDS PRECURSOR (EC 3.4.16.-) - ASPERGILLUS SAITOI (ASPERGILLUS PHOENICIS).
PRTP_HUMAN LYSOSOMAL PROTECTIVE PROTEIN PRECURSOR (EC 3.4.16.5) (CATHEPSIN A) (CARBOXYPEPTIDASE C) - HOMO SAPIENS (HUMAN).
PRTP_MOUSE LYSOSOMAL PROTECTIVE PROTEIN PRECURSOR (EC 3.4.16.5) (CATHEPSIN A) (CARBOXYPEPTIDASE C) (MO54) - MUS MUSCULUS (MOUSE).
Q12569 PREPRO-CARBOXYPEPTIDASE Z (EC 3.4.16.5) (CARBOXYPEPTIDASE C) (SERINE-TYPE CARBOXYPEPTIDASE I) (CATHESPIN A) (CARBOXYPEPTIDASE Y) (LYSOSOMAL PROTECTIVE PROTEIN) - ABSIDIA ZYCHAE.
Q94269 SIMILAR TO SERINE CARBOXYPEPTIDASE - CAENORHABDITIS ELEGANS.
SXA2_SCHPO CARBOXYPEPTIDASE SXA2 PRECURSOR (EC 3.4.16.-) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
VCP_AEDAE VITELLOGENIC CARBOXYPEPTIDASE PRECURSOR (EC 3.4.16.-) - AEDES AEGYPTI (YELLOWFEVER MOSQUITO).
YBY9_YEAST PUTATIVE SERINE CARBOXYPEPTIDASE IN ESR1-IRA1 INTERGENIC REGION (EC 3.4.16.-) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
YSS2_CAEEL PUTATIVE SERINE CARBOXYPEPTIDASE K10B2.2 PRECURSOR (EC 3.4.16.-) - CAENORHABDITIS ELEGANS.
YUA6_CAEEL PUTATIVE SERINE CARBOXYPEPTIDASE F13S12.6 PRECURSOR (EC 3.4.16.-) - CAENORHABDITIS ELEGANS.
YUW5_CAEEL PUTATIVE SERINE CARBOXYPEPTIDASE F41C3.5 PRECURSOR (EC 3.4.16.-) - CAENORHABDITIS ELEGANS.
YXD2_CAEEL PUTATIVE SERINE CARBOXYPEPTIDASE C08H9.1 (EC 3.4.16.-) - CAENORHABDITIS ELEGANS.
YYP3_CAEEL PUTATIVE SERINE CARBOXYPEPTIDASE F32A5.3 PRECURSOR (EC 3.4.16.-) - CAENORHABDITIS ELEGANS.
Scan History
OWL29_1    3  100  NSINGLE    
SPTR37_9f 2 66 NSINGLE
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
NEYRWNKVANVLF CBP2_WHEAT 91 91 -
NPYSWNLIANVLY PRTP_HUMAN 113 113 -
NPYSWNRVSNILY NF31_NAEFO 96 96 -
NEYAWNKFANVLF YSS2_CAEEL 104 104 -
NPYSWNGNASIIY CBPY_PICPA 186 186 -
NPYAWSKVSTMIY CBP1_HORVU 92 92 -
NEYGWDQVSNLLY CBPX_ARATH 163 163 -
NENSWNNYANMIY CPS1_PENJA 80 80 -
NDFGWDQESNLIY CBPX_ORYSA 82 82 -
NEYSWNKMASVVY YUW5_CAEEL 97 97 -
NPYSWTNLTNVVY PEPS_ASPSA 143 143 -
NEGSWISKGDLLF KEX1_YEAST 125 125 -
REYSWHQNHHMIY VCP_AEDAE 141 141 -
NPYSWVNLTNVLW PEPF_ASPNG 149 149 -
NPESWTNFANMLW SXA2_SCHPO 136 136 -

Motif 2 width=11
Element Seqn Id St Int Rpt
LDSPAGVGFSY CBP2_WHEAT 104 0 -
LESPAGVGFSY PRTP_HUMAN 126 0 -
IEQPVGVGFSY NF31_NAEFO 109 0 -
LESPAGVGYSY YSS2_CAEEL 117 0 -
LDQPVNVGFSY CBPY_PICPA 199 0 -
LDSPAGVGLSY CBP1_HORVU 105 0 -
VDQPVGTGFSY CBPX_ARATH 176 0 -
IDQPIGVGFSY CPS1_PENJA 93 0 -
VDQPTGTGFSY CBPX_ORYSA 95 0 -
IESPAGVGYSY YUW5_CAEEL 110 0 -
IDQPAGTGFSP PEPS_ASPSA 156 0 -
IDQPTGTGFSV KEX1_YEAST 138 0 -
IDNPVGTGFSF VCP_AEDAE 154 0 -
VDQPVGTGFSL PEPF_ASPNG 162 0 -
LDQPFGTGYSQ SXA2_SCHPO 149 0 -

Motif 3 width=26
Element Seqn Id St Int Rpt
WFERFPHYKYRDFYIAGESYAGHYVP CBP2_WHEAT 140 25 -
FFRLFPEYKNNKLFLTGESYAGIYIP PRTP_HUMAN 160 23 -
FLTRFPQFIGRETYLAGESYGGVYVP NF31_NAEFO 145 25 -
FLSKFPEYKGRDFWITGESYAGVYIP YSS2_CAEEL 151 23 -
FFQHFPEYQTNDFHIAGESYAGHYIP CBPY_PICPA 231 21 -
WFQLYPEFLSNPFYIAGESYAGVYVP CBP1_HORVU 140 24 -
FFAEHPKLAKNDFYITGESYAGHYIP CBPX_ARATH 211 24 -
FYAQRPEYESRDFAIFTESYGGHYGP CPS1_PENJA 125 21 -
FFTEHPNFAKNDFYITGESYAGHYIP CBPX_ORYSA 130 24 -
FFTEFPQFRHHQTFIMGESYGGVYVP YUW5_CAEEL 144 23 -
HFVDTFDLHGRKVYITGESYAGMYVP PEPS_ASPSA 187 20 -
YFKIFPEDLTRKIILSGESYAGQYIP KEX1_YEAST 180 31 -
FFVLFPNLLKHPFYISGESYGGKFVP VCP_AEDAE 189 24 -
NWQQIFGIKNFKIYVTGESYAGRYVP PEPF_ASPNG 193 20 -
FYQKFPHLMKKKLYLVGESYGSIWSA SXA2_SCHPO 182 22 -

Motif 4 width=14
Element Seqn Id St Int Rpt
LTLVSVRGAGHEVP CBP2_WHEAT 382 216 -
IAFLTIKGAGHMVP PRTP_HUMAN 447 261 -
LTFITVRGAGHMVP NF31_NAEFO 449 278 -
VDFLTVRGSGHFVP YSS2_CAEEL 431 254 -
FTYLRVYDAGHMAP CBPY_PICPA 488 231 -
LTFATIKGAGHTVP CBP1_HORVU 436 270 -
LSFLKVRDAGHMVP CBPX_ARATH 464 227 -
FSFLKVYGAGHEVP CPS1_PENJA 387 236 -
LSFLKVHDAGHMVP CBPX_ORYSA 383 227 -
LSFITIRGAGHMAP YUW5_CAEEL 436 266 -
LTFSSVYLSGHEIP PEPS_ASPSA 478 265 -
LTFVSVYNASHMVP KEX1_YEAST 460 254 -
LQEVLIRNAGHMVP VCP_AEDAE 438 223 -
LMWAETFQSGHMQP PEPF_ASPNG 496 277 -
LAFTLSNSVGHMAP SXA2_SCHPO 477 269 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
NEYRWNKVANVLF CBP2_WHEAT 91 91 -
NPYAWNKEANMLF O04084 131 131 -
NPYAWNKEANILF O22732 112 112 -
NEYRWNKVANVLF P93177 123 123 -
NEYRWNKVANVLF CBP2_HORVU 89 89 -
NPYAWNKEVNMLF O23364 44 44 -
NNFSWNTEANLLF O82228 122 122 -
NPYSWNHAANVLF CP23_HORVU 169 169 -
NPYSWNLIANVLY O60790 113 113 -
NPYSWNLIANVLY PRTP_HUMAN 113 113 -
NKFTWNTEANILF O82229 82 82 -
NPYSWNKNASILT YUA6_CAEEL 103 103 -
NPYSWNRVSNILY NF31_NAEFO 96 96 -
NPYAWNLIANVLY PRTP_MOUSE 108 108 -
NPYSWNNNASMIF YBY9_YEAST 156 156 -
NPYSWSKVSSVIY CBP1_ORYSA 128 128 -
NEYAWNKFANVLF YSS2_CAEEL 104 104 -
NQYSWNQAANILF O65568 119 119 -
NVYSWNKAANVIF Q94269 679 679 -
NPYSWNGNASIIY CBPY_PICPA 186 186 -
NQHSWNQEANMLY O22803 112 112 -
NPYAWSKVSTMIY CBP1_HORVU 92 92 -
NEYGWDQVSNLLY CBPX_ARATH 163 163 -
NPHSWNANASVIF CBPY_CANAL 206 206 -
NKFGWDKISNIIF CBP3_HORVU 157 157 -
NKFGWDKISNIIF P93178 157 157 -
NPYSWNSNATVIF O14414 196 196 -
NKFGWDTISNIIF CBP3_ORYSA 150 150 -
NPYAWNAKANVLY YYP3_CAEEL 104 104 -
NENSWNNYANMIY CPS1_PENJA 80 80 -
NDFGWDQESNLIY CBPX_ORYSA 82 82 -
NEYSWNKMASVVY YUW5_CAEEL 97 97 -
NPHSWHHSSNMLF Q12569 123 123 -
NPYSWNSNATVIF CBPY_YEAST 191 191 -
NKFGWDKISNIIF CBP3_WHEAT 150 150 -
TTYSWTKTANIIF O64811 110 110 -
TTYSWTKMANIIY O64810 110 110 -
TTYSWTKTANIIF O64807 110 110 -
NPWTWNRIANIIY O76725 100 100 -
TTYSWTKTANIIF O81009 110 110 -
NPHSWNSNASVIF O13849 652 652 -
TTYSWTKMANIIF O64809 108 108 -
TTYSWTKMANIIF O64808 111 111 -
NVHSWYHKANILF YXD2_CAEEL 104 104 -
NPYSWTNLTNVVY PEPS_ASPSA 143 143 -
NPGRWDELGNLLF O60123 110 110 -
NEGSWISKGDLLF KEX1_YEAST 125 125 -
REYSWHQNHHMIY VCP_AEDAE 141 141 -
NEGTWVEAADVVF O74702 114 114 -
NPYSWVNLTNVLW PEPF_ASPNG 149 149 -
NPATWLQVADMVY O45916 850 850 -
NPESWTNFANMLW SXA2_SCHPO 136 136 -

Motif 2 width=11
Element Seqn Id St Int Rpt
LDSPAGVGFSY CBP2_WHEAT 104 0 -
LESPVGVGFSY O04084 144 0 -
LESPAGVGFSY O22732 125 0 -
LDSPAGVGFSY P93177 136 0 -
LDSPAGVGFSY CBP2_HORVU 102 0 -
LESPVGVGFSY O23364 57 0 -
LESPVGVGFSY O82228 135 0 -
LESPAGVGYSY CP23_HORVU 182 0 -
LESPAGVGFSY O60790 126 0 -
LESPAGVGFSY PRTP_HUMAN 126 0 -
LESPAGVGFSY O82229 95 0 -
LEAPAGVGYSY YUA6_CAEEL 116 0 -
IEQPVGVGFSY NF31_NAEFO 109 0 -
IESPAGVGFSY PRTP_MOUSE 121 0 -
LEQPLGVGFSY YBY9_YEAST 169 0 -
LDSPAGVGLSY CBP1_ORYSA 141 0 -
LESPAGVGYSY YSS2_CAEEL 117 0 -
LDAPVGVGYSY O65568 132 0 -
LESPRGVGFSV Q94269 692 0 -
LDQPVNVGFSY CBPY_PICPA 199 0 -
LETPVGVGFSY O22803 125 0 -
LDSPAGVGLSY CBP1_HORVU 105 0 -
VDQPVGTGFSY CBPX_ARATH 176 0 -
LDQPINVGYSY CBPY_CANAL 219 0 -
VDQPTGTGFSY CBP3_HORVU 170 0 -
VDQPTGTGFSY P93178 170 0 -
LDQPVNVGFSY O14414 209 0 -
VDQPTGTGFSY CBP3_ORYSA 163 0 -
LESPIGVGYSY YYP3_CAEEL 117 0 -
IDQPIGVGFSY CPS1_PENJA 93 0 -
VDQPTGTGFSY CBPX_ORYSA 95 0 -
IESPAGVGYSY YUW5_CAEEL 110 0 -
FDQPDGVGFSY Q12569 136 0 -
LDQPVNVGFSY CBPY_YEAST 204 0 -
VDPATGTGFSY CBP3_WHEAT 163 0 -
LDQPVGSGFSY O64811 123 0 -
LDQPVGSGFSY O64810 123 0 -
LDQPVGAGFSY O64807 123 0 -
LDAPAGVGFSY O76725 113 0 -
LDQPIGAGFSY O81009 123 0 -
LDQPINTGFSN O13849 665 0 -
LDQPVGSGFSY O64809 121 0 -
LDQPVGSGFSY O64808 124 0 -
LESPIGVGFSY YXD2_CAEEL 117 0 -
IDQPAGTGFSP PEPS_ASPSA 156 0 -
VDQPLGTGYSY O60123 123 0 -
IDQPTGTGFSV KEX1_YEAST 138 0 -
IDNPVGTGFSF VCP_AEDAE 154 0 -
VDQPGGTGFSS O74702 127 0 -
VDQPVGTGFSL PEPF_ASPNG 162 0 -
VDNPVGAGFSY O45916 863 0 -
LDQPFGTGYSQ SXA2_SCHPO 149 0 -

Motif 3 width=26
Element Seqn Id St Int Rpt
WFERFPHYKYRDFYIAGESYAGHYVP CBP2_WHEAT 140 25 -
WFEKFPEHKENTFYIAGESYAGKYVP O04084 180 25 -
WFLRFPAYKEKDFFIAGESYAGKYVP O22732 161 25 -
WFERFPHYKYREFYVAGESYAGHYVP P93177 172 25 -
WFERFPHYKRREFYVAGESYAGHYVP CBP2_HORVU 138 25 -
WFEKFPEHKGNEFYIAGESYAGIYVP O23364 93 25 -
WMSRFPQYRYRDFYIVGESYAGHYVP O82228 171 25 -
WLERFPEYKGREFYITGESYAGHYVP CP23_HORVU 218 25 -
FFRLFPEYKNNKLFLTGESYAGIYIP O60790 160 23 -
FFRLFPEYKNNKLFLTGESYAGIYIP PRTP_HUMAN 160 23 -
WMSRFPQYQYRDFYIVGESYAGHYVP O82229 131 25 -
FFNEFPQYKGNDFYVTGESYGGIYVP YUA6_CAEEL 150 23 -
FLTRFPQFIGRETYLAGESYGGVYVP NF31_NAEFO 145 25 -
FFRLFPEYKDNKLFLTGESYAGIYIP PRTP_MOUSE 155 23 -
FFEAFPHLRSNDFHIAGESYAGHYIP YBY9_YEAST 201 21 -
WFQLYPEFLSNPFYIAGESYAGVYVP CBP1_ORYSA 176 24 -
FLSKFPEYKGRDFWITGESYAGVYIP YSS2_CAEEL 151 23 -
WVERFPEYKGRDFYIVGESYAGNGLM O65568 168 25 -
FFNKFPEYQNRPFYITGESYGGIYVP Q94269 1287 584 -
FFQHFPEYQTNDFHIAGESYAGHYIP CBPY_PICPA 231 21 -
WFLKFPQYLNRSLFITGESYAGHYVP O22803 161 25 -
WFQLYPEFLSNPFYIAGESYAGVYVP CBP1_HORVU 140 24 -
FFAEHPKLAKNDFYITGESYAGHYIP CBPX_ARATH 211 24 -
FFKNFPEYANLDFHIAGESYAGHYIP CBPY_CANAL 251 21 -
FFKKHPEFIKNDFFITGESYAGHYIP CBP3_HORVU 205 24 -
FFKKHPEFIKNDFFITGESYAGHYIP P93178 205 24 -
FYQQFPHLLKNDFHIAGESYGGHYIP O14414 241 21 -
FFKKHPEFAKNDFFITGESYAGHYIP CBP3_ORYSA 198 24 -
FNVAQPKYTNRTFYLSGESYAGIYIP YYP3_CAEEL 154 26 -
FYAQRPEYESRDFAIFTESYGGHYGP CPS1_PENJA 125 21 -
FFTEHPNFAKNDFYITGESYAGHYIP CBPX_ORYSA 130 24 -
FFTEFPQFRHHQTFIMGESYGGVYVP YUW5_CAEEL 144 23 -
FYETFPQYSKLDVHYFGESYGGHYIP Q12569 168 21 -
DQFPEYVNKGQDFHIAGESYAGHYIP CBPY_YEAST 239 24 -
FFKKHPEFVKNDFFITGESYAGHYIP CBP3_WHEAT 198 24 -
WLIKHPQFLSNPFYVVGDSYSGMIVP O64811 157 23 -
WLSKHPQFFSNPFYVTGDSYSGMIVP O64810 157 23 -
WLSKHPQFSSNHFYAGGDSYSGMIVP O64807 158 24 -
WFARFPERKTNDFYIAGESYGGTYVP O76725 147 23 -
WLSKHPQFSSNPFYASGDSYSGMIVP O81009 158 24 -
FFAKFPQYAHLDFHIAGESYAGHYIP O13849 697 21 -
WLSRHPQYFSNPLYVVGDSYSGMIVP O64809 155 23 -
WLSKHQQFFSNPFYVGGDSYSGMIVP O64808 159 24 -
FQRKHSSYVNHDFFIAAESYGGVYGP YXD2_CAEEL 154 26 -
HFVDTFDLHGRKVYITGESYAGMYVP PEPS_ASPSA 187 20 -
FLEEFPERANDEWFIAGESFAGQYIP O60123 157 23 -
YFKIFPEDLTRKIILSGESYAGQYIP KEX1_YEAST 180 31 -
FFVLFPNLLKHPFYISGESYGGKFVP VCP_AEDAE 189 24 -
YFHLFPADVYKKFTLGGESYAGQYVP O74702 159 21 -
NWQQIFGIKNFKIYVTGESYAGRYVP PEPF_ASPNG 193 20 -
FLALHPEYRTRPFYIFCESYGGKMSA O45916 898 24 -
FYQKFPHLMKKKLYLVGESYGSIWSA SXA2_SCHPO 182 22 -

Motif 4 width=14
Element Seqn Id St Int Rpt
LTLVSVRGAGHEVP CBP2_WHEAT 382 216 -
LTFATFRGAGHAVP O04084 428 222 -
LTFATFRGAGHDVP O22732 433 246 -
LTLVSVRGAGHEVP P93177 433 235 -
LTLVSVRGAGHEVP CBP2_HORVU 380 216 -
LTFATFRGAGHTVP O23364 366 247 -
LTFVTVRGAGHEVP O82228 437 240 -
LSLVTVRGAGHEVP CP23_HORVU 474 230 -
IAFLTIKGAGHMVP O60790 447 261 -
IAFLTIKGAGHMVP PRTP_HUMAN 447 261 -
LTFATIRGAGHEVP O82229 388 231 -
VTFATVRGAGHMVP YUA6_CAEEL 421 245 -
LTFITVRGAGHMVP NF31_NAEFO 449 278 -
ITFLTIKGAGHMVP PRTP_MOUSE 441 260 -
FTFLRIYDAGHMVP YBY9_YEAST 464 237 -
LTFATIKGAGHTVP CBP1_ORYSA 477 275 -
VDFLTVRGSGHFVP YSS2_CAEEL 431 254 -
LNFVTVRGAGHEVP O65568 374 180 -
IDLLTVKGAGHMSP Q94269 2138 825 -
FTYLRVYDAGHMAP CBPY_PICPA 488 231 -
LAFATVRGAAHEVP O22803 421 234 -
LTFATIKGAGHTVP CBP1_HORVU 436 270 -
LSFLKVRDAGHMVP CBPX_ARATH 464 227 -
FTFLRVFGGGHMVP CBPY_CANAL 508 231 -
LSFLKVHNAGHMVP CBP3_HORVU 458 227 -
LSFLKVHNAGHMVP P93178 458 227 -
FTFARMFDGGHMVP O14414 499 232 -
LSFLKVHNAGHMVP CBP3_ORYSA 451 227 -
IDLLTVKGAGHMVP YYP3_CAEEL 497 317 -
FSFLKVYGAGHEVP CPS1_PENJA 387 236 -
LSFLKVHDAGHMVP CBPX_ORYSA 383 227 -
LSFITIRGAGHMAP YUW5_CAEEL 436 266 -
LTFVRVYEAGHEVP Q12569 426 232 -
FTYLRVFNGGHMVP CBPY_YEAST 498 233 -
LSFLKVHNAGHMVP CBP3_WHEAT 451 227 -
MTFATVKGGGHTAE O64811 405 222 -
MTFATVKGGGHTAE O64810 405 222 -
MTFATVKGSGHTAE O64807 401 217 -
ITLISIKGGGHFPA O76725 442 269 -
MTFATVKGSGHTAE O81009 403 219 -
FGYLRLYEAGHMVP O13849 968 245 -
MTFATIKGGGHTAE O64809 401 220 -
MTFATIKGSGHTAE O64808 398 213 -
IDVVTVKGSGHFVP YXD2_CAEEL 463 283 -
LTFSSVYLSGHEIP PEPS_ASPSA 478 265 -
LTFARIVEASHMVP O60123 417 234 -
LTFVSVYNASHMVP KEX1_YEAST 460 254 -
LQEVLIRNAGHMVP VCP_AEDAE 438 223 -
LTYVRVYNSSHMVP O74702 431 246 -
LMWAETFQSGHMQP PEPF_ASPNG 496 277 -
LQFWWILRAGHMVA O45916 1170 246 -
LAFTLSNSVGHMAP SXA2_SCHPO 477 269 -