| Literature References | 1. WO, Y.Y., MCCORMACK, A.L., SHABANOWITZ, J., HUNT, D.F., DAVIS, J.P.,
MITCHELL, G.L. AND VAN ETTEN, R.L.
Sequencing, cloning, and expression of human red cell-type acid phosphatase,
a cytoplasmic phosphotyrosyl protein phosphatase.
J.BIOL.CHEM. 267(15) 10856-10865 (1992).
2. SHEKELS, L.L., SMITH, A.J., VAN ETTEN, R.L. AND BERNLOHR, D.A.
Identification of the adipocyte acid phosphatase as a PAO-sensitive
tyrosyl phosphatase.
PROTEIN SCI. 1(6) 710-721 (1992).
3. LOGAN, T.M., ZHOU, M.M., NETTESHEIM, D.G., MEADOWS, R.P., VANETTEN, R.L.
AND FESIK, S.W.
Solution structure of a low-molecular-weight protein-tyrosine-phosphatase.
BIOCHEMISTRY 33(37) 11087-11096 (1994).
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| Documentation | Low molecular weight (LMW) phosphotyrosine protein phosphatase (or acid
phosphatase) acts on tyrosine phosphorylated proteins, low-MW aryl
phosphates and natural and synthetic acyl phosphates [1,2]. It is a
cytoplasmic enzyme that catalyses the reaction:
protein tyrosine phosphate + H(2)O = protein tyrosine + orthophosphate.
The structure of the protein has been solved by NMR [3]. It belongs to the
alpha/beta class, with 6 alpha-helices and 4 beta-strands forming a 3-layer
alpha-beta-alpha sandwich architecture.
MAMMALPTPASE is a 5-element fingerprint that provides a signature for
mammalian low molecular weight phosphotyrosine protein phosphatases. The
fingerprint was derived from an initial alignment of 6 sequences: the
motifs were drawn from conserved regions spanning virtually the full
alignment length - motif 1 spans the C-terminus of helix 1 and helix 2;
motif 2 includes helix 4; motif 3 spans the third beta-strand and helix 5;
motif 4 includes the second beta-strand; and motif 5 encompasses helix 6.
Two iterations on OWL29.0 were required to reach convergence, at which
point a true set comprising 7 sequences was identified.
An update on SPTR37_9f identified a true set of 6 sequences.
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| Sequence Titles | O88739 PROTEIN-TYROSINE-PHOSPHATASE (EC 3.1.3.48) (PHOSPHOTYROSINE PHOSPHATASE) (PTPASE) - MUS MUSCULUS (MOUSE).
O88740 PROTEIN-TYROSINE-PHOSPHATASE (EC 3.1.3.48) (PHOSPHOTYROSINE PHOSPHATASE) (PTPASE) - MUS MUSCULUS (MOUSE).
PA1F_HUMAN RED CELL ACID PHOSPHATASE 1, ISOZYME F (EC 3.1.3.2) (ACP1) (LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE) (EC 3.1.3.48) (ADIPOCYTE ACID PHOSPHATASE, ISOZYME ALPHA) - HOMO SAPIENS (HUMAN).
PA1S_HUMAN RED CELL ACID PHOSPHATASE 1, ISOZYME S (EC 3.1.3.2) (ACP1) (LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE) (EC 3.1.3.48) (ADIPOCYTE ACID PHOSPHATASE, ISOZYME BETA) - HOMO SAPIENS (HUMAN).
PPAC_BOVIN LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE (EC 3.1.3.48) (LOW MOLECULAR WEIGHT CYTOSOLIC ACID PHOSPHATASE) (EC 3.1.3.2) (PTPASE) - BOS TAURUS (BOVINE).
PPAC_RAT LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE ACP1/ACP2 (EC 3.1.3.48) (LOW MOLECULAR WEIGHT CYTOSOLIC ACID PHOSPHATASE) (EC 3.1.3.2) (PTPASE) - RATTUS NORVEGICUS (RAT).
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