SPRINT Home UMBER Home Contents Standard Search Advanced Search Relation Search

==SPRINT==> PRINTS View



  selected as


PR00713

Identifier
CNATPEPTIDE  [View Relations]  [View Alignment]  
Accession
PR00713
No. of Motifs
3
Creation Date
01-JUN-1996  (UPDATE 27-JUN-1999)
Title
C-type natriuretic peptide signature
Database References
PRINTS; PR00710 NATPEPTIDES
INTERPRO; IPR002406
Literature References
1. INAGAMI, T.
Atrial natriuretic factor.
J.BIOL.CHEM. 264 3043-3046 (1989).
 
2. SAGNELLA, G.A. AND MCGREGOR, G.A.
Structural and functional features of atrial natriuretic peptides.
TRENDS BIOCHEM.SCI. 11 299-302 (1986).
 
3. ROSENZWEIG, A. AND SEIDMAN, C.E.
Atrial natriuretic factor and related peptide hormones.
ANNU.REV.BIOCHEMISTRY 60 229-255 (1991).
 
4. TAKEI, Y., TAKAHASHI, A., WATANABE, T.X., NAKAJIMA, K.
AND SAKAKIBARA, S.
A novel natriuretic peptide isolated from eel cardiac ventricles.
FEBS LETT. 282 317-320 (1991).
 
5. SCHWEITZ, H., WIGNE, P., MOINIER, D., FRELIN, C. AND LAZDUNSKI, M.
A new member of the natriuretic peptide family is present in the venom of
the green mamba (Dendroaspis angusticeps. 
J.BIOL.CHEM. 267 13928-13932 (1992). 

Documentation
Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an
important role in the control of cardiovascular homeostatis, and sodium
and water balance in general [1-3]. There are different NPs that vary in
length but share a common core. All are processed from a single precursor.
A disulphide bond resident in the C-terminal section is required for full
activity of atriopeptins.
 
The family of NPs includes structurally-related peptides that elicit 
similar pharmacological spectra: amongst these are brain natriuretic
peptide (BNP); C-type natriuretic peptide (CNP); ventricular natriuretic
peptide (VNP) [4]; and green mamba natriuretic peptide (DNP) [5]. 
 
CNATPEPTIDE is a 3-element fingerprint that provides a signature for
C-type natriuretic peptides. The fingerprint was derived from an initial
alignment of 5 sequences: the motifs were drawn from the C-terminal region,
motif 3 spanning the section encoded by PROSITE pattern NATRIURETIC_PEPTIDE
(PS00263), which includes the two functionally important cysteines and two
conserved glycines, which may be important for the conformation of the
peptides. Two iterations on OWL29.3 were required to reach convergence, at
which point a true set comprising 9 sequences was identified. A single
partial match was also found, D85843, a natriuretic peptide homologue that
fails to make a significant match with motif 1.
 
An update on SPTR37_9f identified a true set of 11 sequences, and 1
partial match.
Summary Information
11 codes involving  3 elements
0 codes involving 2 elements
Composite Feature Index
3111111
2000
123
True Positives
ANFC_BOVIN    ANFC_HUMAN    ANFC_MOUSE    ANFC_PIG      
ANFC_RANCA ANFC_RAT ANFC_SCYCA ANFC_SHEEP
ANFC_SQUAC ANFC_TRISC ANFD_RANCA
Sequence Titles
ANFC_BOVIN  C-TYPE NATRIURETIC PEPTIDE PRECURSOR (SVSP15) [CONTAINS: CNP-22; CNP- 29; CNP-53] - BOS TAURUS (BOVINE). 
ANFC_HUMAN C-TYPE NATRIURETIC PEPTIDE PRECURSOR [CONTAINS: CNP-22; CNP-29; CNP- 53] - HOMO SAPIENS (HUMAN).
ANFC_MOUSE C-TYPE NATRIURETIC PEPTIDE PRECURSOR [CONTAINS: CNP-22; CNP-29; CNP- 53] - MUS MUSCULUS (MOUSE).
ANFC_PIG C-TYPE NATRIURETIC PEPTIDE PRECURSOR [CONTAINS: CNP-22; CNP-29; CNP- 53] - SUS SCROFA (PIG).
ANFC_RANCA C-TYPE NATRIURETIC PEPTIDE 1 PRECURSOR (CNP I) - RANA CATESBEIANA (BULL FROG).
ANFC_RAT C-TYPE NATRIURETIC PEPTIDE PRECURSOR [CONTAINS: CNP-22; CNP-29; CNP- 53] - RATTUS NORVEGICUS (RAT).
ANFC_SCYCA C-TYPE NATRIURETIC PEPTIDE (CNP-115) - SCYLIORHINUS CANICULA (SPOTTED DOGFISH) (SPOTTED CATSHARK).
ANFC_SHEEP C-TYPE NATRIURETIC PEPTIDE PRECURSOR [CONTAINS: CNP-22; CNP-29; CNP- 53] - OVIS ARIES (SHEEP).
ANFC_SQUAC C-TYPE NATRIURETIC PEPTIDE PRECURSOR - SQUALUS ACANTHIAS (SPINY DOGFISH).
ANFC_TRISC C-TYPE NATRIURETIC PEPTIDE (CNP-115) - TRIAKIS SCYLLIUM (LEOPARD SHARK) (TRIAKIS SCYLLIA).
ANFD_RANCA C-TYPE NATRIURETIC PEPTIDE 2 PRECURSOR (CNP II) - RANA CATESBEIANA (BULL FROG).
Scan History
OWL29_3    2  50   NSINGLE    
SPTR37_9f 2 200 NSINGLE
Initial Motifs
Motif 1  width=11
Element Seqn Id St Int Rpt
SRAAWARLLHE ANFC_PIG 81 81 -
SRAAWARLLQE ANFC_HUMAN 81 81 -
QEAVLARLLKD ANFC_SCYCA 69 69 -
QEALLARLLQD ANFC_SQUAC 89 89 -
NEMTLQQLLND ANFC_RANCA 83 83 -

Motif 2 width=17
Element Seqn Id St Int Rpt
NARKYKGGNKKGLSKGC ANFC_PIG 94 2 -
NARKYKGANKKGLSKGC ANFC_HUMAN 94 2 -
NPLRFRGRSKKGPSRGC ANFC_SCYCA 83 3 -
NPLRFKGRSKKGPSRSC ANFC_SQUAC 103 3 -
TSRRYRQRNKKGYSRGC ANFC_RANCA 97 3 -

Motif 3 width=16
Element Seqn Id St Int Rpt
CFGLKLDRIGSMSGLG ANFC_PIG 110 -1 -
CFGLKLDRIGSMSGLG ANFC_HUMAN 110 -1 -
CFGVKLDRIGAMSGLG ANFC_SCYCA 99 -1 -
CFGLKLDRIGAMSGLG ANFC_SQUAC 119 -1 -
CFGVKLDRIGAFSGLG ANFC_RANCA 113 -1 -
Final Motifs
Motif 1  width=11
Element Seqn Id St Int Rpt
SRAAWARLLHE ANFC_MOUSE 81 81 -
SRAAWARLLHE ANFC_RAT 81 81 -
SRAAWARLLHE ANFC_PIG 81 81 -
SRAAWTRLLHE ANFC_SHEEP 81 81 -
SRAAWTRLLHE ANFC_BOVIN 81 81 -
SRAAWARLLQE ANFC_HUMAN 81 81 -
SRAAWTRLLNE ANFD_RANCA 73 73 -
QEAVLARLLKD ANFC_SCYCA 69 69 -
QEAVLARLLKD ANFC_TRISC 69 69 -
QEALLARLLQD ANFC_SQUAC 89 89 -
NEMTLQQLLND ANFC_RANCA 83 83 -

Motif 2 width=17
Element Seqn Id St Int Rpt
NARKYKGGNKKGLSKGC ANFC_MOUSE 94 2 -
NARKYKGGNKKGLSKGC ANFC_RAT 94 2 -
NARKYKGGNKKGLSKGC ANFC_PIG 94 2 -
NARKYKGGNKKGLSKGC ANFC_SHEEP 94 2 -
NARKYKGGNKKGLSKGC ANFC_BOVIN 94 2 -
NARKYKGANKKGLSKGC ANFC_HUMAN 94 2 -
NSRKIKGINKKGTSKGC ANFD_RANCA 86 2 -
NPLRFRGRSKKGPSRGC ANFC_SCYCA 83 3 -
NPLRFRGRSKKGPSRGC ANFC_TRISC 83 3 -
NPLRFKGRSKKGPSRSC ANFC_SQUAC 103 3 -
TSRRYRQRNKKGYSRGC ANFC_RANCA 97 3 -

Motif 3 width=16
Element Seqn Id St Int Rpt
CFGLKLDRIGSMSGLG ANFC_MOUSE 110 -1 -
CFGLKLDRIGSMSGLG ANFC_RAT 110 -1 -
CFGLKLDRIGSMSGLG ANFC_PIG 110 -1 -
CFGLKLDRIGSMSGLG ANFC_SHEEP 110 -1 -
CFGLKLDRIGSMSGLG ANFC_BOVIN 110 -1 -
CFGLKLDRIGSMSGLG ANFC_HUMAN 110 -1 -
CFGLKLDRIGAMSGLG ANFD_RANCA 102 -1 -
CFGVKLDRIGAMSGLG ANFC_SCYCA 99 -1 -
CFGVKLDRIGAMSGLG ANFC_TRISC 99 -1 -
CFGLKLDRIGAMSGLG ANFC_SQUAC 119 -1 -
CFGVKLDRIGAFSGLG ANFC_RANCA 113 -1 -