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PR00711

Identifier
ANATPEPTIDE  [View Relations]  [View Alignment]  
Accession
PR00711
No. of Motifs
7
Creation Date
01-JUN-1996  (UPDATE 13-JUN-1999)
Title
Atrial natriuretic peptide signature
Database References
PRINTS; PR00710 NATPEPTIDES
PFAM; PF00212 ANP
INTERPRO; IPR002407
Literature References
1. INAGAMI, T.
Atrial natriuretic factor.
J.BIOL.CHEM. 264 3043-3046 (1989).
 
2. SAGNELLA, G.A. AND MCGREGOR, G.A.
Structural and functional features of atrial natriuretic peptides.
TRENDS BIOCHEM.SCI. 11 299-302 (1986).
 
3. ROSENZWEIG, A. AND SEIDMAN, C.E.
Atrial natriuretic factor and related peptide hormones.
ANNU.REV.BIOCHEMISTRY 60 229-255 (1991).
 
4. TAKEI, Y., TAKAHASHI, A., WATANABE, T.X., NAKAJIMA, K.
AND SAKAKIBARA, S.
A novel natriuretic peptide isolated from eel cardiac ventricles.
FEBS LETT. 282 317-320 (1991).
 
5. SCHWEITZ, H., WIGNE, P., MOINIER, D., FRELIN, C. AND LAZDUNSKI, M.
A new member of the natriuretic peptide family is present in the venom of
the green mamba (Dendroaspis angusticeps. 
J.BIOL.CHEM. 267 13928-13932 (1992). 

Documentation
Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an
important role in the control of cardiovascular homeostatis, and sodium
and water balance in general [1-3]. There are different NPs that vary in
length but share a common core. All are processed from a single precursor.
A disulphide bond resident in the C-terminal section is required for full
activity of atriopeptins.
 
The family of NPs includes structurally-related peptides that elicit 
similar pharmacological spectra: amongst these are brain natriuretic
peptide (BNP); C-type natriuretic peptide (CNP); ventricular natriuretic
peptide (VNP) [4]; and green mamba natriuretic peptide (DNP) [5]. 
 
ANATPEPTIDE is a 7-element fingerprint that provides a signature for atrial
natriuretic peptides. The fingerprint was derived from an initial alignment
of 8 sequences: the motifs were drawn from conserved regions spanning the
full alignment length - motif 7 spans the C-terminal region encoded by
PROSITE pattern NATRIURETIC_PEPTIDE (PS00263), which includes the two
functionally important cysteines and two conserved glycines, which may be
important for the conformation of the peptides. Two iterations on OWL29.3
were required to reach convergence, at which point a true set comprising
10 sequences was identified. Several partial matches were also found, all
of which are natriuretic peptide fragments.
 
An update on SPTR37_9f identified a true set of 10 sequences, and 3
partial matches.
Summary Information
  10 codes involving  7 elements
1 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
1 codes involving 3 elements
1 codes involving 2 elements
Composite Feature Index
710101010101010
61111011
50000000
40000000
30100011
21000001
1234567
True Positives
ANF_BOVIN     ANF_CANFA     ANF_HORSE     ANF_HUMAN     
ANF_MOUSE ANF_PIG ANF_RABIT ANF_RAT
Q13766 Q29130
True Positive Partials
Codes involving 6 elements
O46540
Codes involving 3 elements
ANF_RANCA
Codes involving 2 elements
ANF_CHICK
Sequence Titles
ANF_BOVIN   ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - BOS TAURUS (BOVINE). 
ANF_CANFA ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - CANIS FAMILIARIS (DOG).
ANF_HORSE ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - EQUUS CABALLUS (HORSE).
ANF_HUMAN ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - HOMO SAPIENS (HUMAN).
ANF_MOUSE ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - MUS MUSCULUS (MOUSE).
ANF_PIG ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - SUS SCROFA (PIG).
ANF_RABIT ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - ORYCTOLAGUS CUNICULUS (RABBIT).
ANF_RAT ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) [CONTAINS: AURICULINS; ATRIOPEPTINS] - RATTUS NORVEGICUS (RAT).
Q13766 ATRIAL NATRIURETIC FACTOR PRECURSOR - HOMO SAPIENS (HUMAN).
Q29130 CARDIODILATIN, ATRIAL NATRIURETIC PEPTIDE - TUPAIA BELANGERI.

O46540 ATRIAL NATRIURETIC PEPTIDE - OVIS ARIES (SHEEP).

ANF_RANCA ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) - RANA CATESBEIANA (BULL FROG).

ANF_CHICK ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - GALLUS GALLUS (CHICKEN).
Scan History
OWL29_3    2  50   NSINGLE    
SPTR37_9f 2 30 NSINGLE
Initial Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
FLLLLAFQLLGQTRANPMY ANF_HUMAN 11 11 -
FLLFLAFQLQGQTRANPVY ANF_HORSE 11 11 -
FLLVLVFQFPGQTRANPVY ANF_PIG 10 10 -
FLLFLAVQLLGQTGANPVY ANF_CANFA 9 9 -
FFLFLAFWLPGHIGANPVY ANF_RAT 10 10 -
FLLFLAFQLPGQTGANPVY ANF_BOVIN 10 10 -
FFLVLAFWLPGHIGANPVY ANF_MOUSE 10 10 -
FLFCLAFWHPDQIGANPVY ANF_RABIT 11 11 -

Motif 2 width=19
Element Seqn Id St Int Rpt
VSNADLMDFKNLLDHLEEK ANF_HUMAN 32 2 -
VSNGDLMDFKNLLDRLEDK ANF_HORSE 32 2 -
VSNADLMDFKNLLDHLEDK ANF_PIG 31 2 -
VSNADLLDFKNLLDRLEDK ANF_CANFA 30 2 -
VSNTDLMDFKNLLDHLEEK ANF_RAT 31 2 -
VSNADLMDFKNLLDRLEDK ANF_BOVIN 31 2 -
VSNTDLMDFKNLLDHLEEK ANF_MOUSE 31 2 -
MSNADLMDFKNLLDHLEDR ANF_RABIT 32 2 -

Motif 3 width=19
Element Seqn Id St Int Rpt
MPLEDEVVPPQVLSEPNEE ANF_HUMAN 51 0 -
MPLEDEVMPPQVLSDQSEE ANF_HORSE 51 0 -
MPLEDEAMPPQVLSEQNEE ANF_PIG 50 0 -
MPLEDEAESPQALSEQNAE ANF_CANFA 49 0 -
MPVEDEVMPPQALSEQTDE ANF_RAT 50 0 -
MPLEDEAVPSQVLSEQNEE ANF_BOVIN 50 0 -
MPVEDEVMPPQALSEQTEE ANF_MOUSE 50 0 -
MPFEDEAVPPQALSEQSDE ANF_RABIT 51 0 -

Motif 4 width=18
Element Seqn Id St Int Rpt
AALSPLPEVPPWTGEVSP ANF_HUMAN 72 2 -
AALSPLPEVPPWTGEVNP ANF_HORSE 72 2 -
APLSPLLEVPPWTGEVNP ANF_PIG 71 2 -
AALSPLPEVPPWTGEVSP ANF_CANFA 70 2 -
AALSSLSEVPPWTGEVNP ANF_RAT 71 2 -
APLSPLSEMPPWMGEVNP ANF_BOVIN 71 2 -
AALSSLPEVPPWTGEVNP ANF_MOUSE 71 2 -
AALSPLPEVPPWTGEVSP ANF_RABIT 72 2 -

Motif 5 width=17
Element Seqn Id St Int Rpt
RDGGALGRGPWDSSDRS ANF_HUMAN 92 2 -
RDGGALGRGSWDSSDRS ANF_HORSE 92 2 -
RDGGALGRGPWDASDRS ANF_PIG 91 2 -
RDGGALGRSPWDSSDRS ANF_CANFA 90 2 -
RDGGALGRGPWDPSDRS ANF_RAT 91 2 -
REGGVLGRGPWESSDRS ANF_BOVIN 91 2 -
RDGSASRRSPWDPSDRS ANF_MOUSE 91 2 -
RDGEALGRSTWEASERS ANF_RABIT 92 2 -

Motif 6 width=19
Element Seqn Id St Int Rpt
ALLKSKLRALLTAPRSLRR ANF_HUMAN 109 0 -
ALLKSKLRALLAAPRSLRR ANF_HORSE 109 0 -
ALLKSKLRALLAAPRSLRR ANF_PIG 108 0 -
ALLKSKLRALLAAPRSLRR ANF_CANFA 107 0 -
ALLKSKLRALLAGPRSLRR ANF_RAT 108 0 -
ALLKSKLRALLTAPRSLRR ANF_BOVIN 108 0 -
ALLKSKLRALLAGPRSLRR ANF_MOUSE 108 0 -
ALLKSKLRALLTAPRSLRR ANF_RABIT 109 0 -

Motif 7 width=23
Element Seqn Id St Int Rpt
SSCFGGRMDRIGAQSGLGCNSFR ANF_HUMAN 128 0 -
SSCFGGRMDRIGAQSGLGCNSFR ANF_HORSE 128 0 -
SSCFGGRMDRIGAQSGLGCNSFR ANF_PIG 127 0 -
SSCFGGRMDRIGAQSGLGCNSFR ANF_CANFA 126 0 -
SSCFGGRIDRIGAQSGLGCNSFR ANF_RAT 127 0 -
SSCFGGRMDRIGAQSGLGCNSFR ANF_BOVIN 127 0 -
SSCFGGRIDRIGAQSGLGCNSFR ANF_MOUSE 127 0 -
SSCFGGRIDRIGAQSGLGCNSFR ANF_RABIT 128 0 -
Final Motifs
Motif 1  width=19
Element Seqn Id St Int Rpt
FLLLLAFQLLGQTRANPMY ANF_HUMAN 11 11 -
FLLLLAFQLLGQTRANPMY Q13766 11 11 -
FLLFLAFQLQGQTRANPVY ANF_HORSE 11 11 -
FLLVLVFQFPGQTRANPVY ANF_PIG 10 10 -
FLLFLAVQLLGQTGANPVY ANF_CANFA 9 9 -
FFLFLAFWLPGHIGANPVY ANF_RAT 10 10 -
FLLFLAFQLPGQTGANPVY ANF_BOVIN 10 10 -
FFLVLAFWLPGHIGANPVY ANF_MOUSE 10 10 -
FLFCLAFWHPDQIGANPVY ANF_RABIT 11 11 -
FLVFLLPGQMGHIGASPVY Q29130 13 13 -

Motif 2 width=19
Element Seqn Id St Int Rpt
VSNADLMDFKNLLDHLEEK ANF_HUMAN 32 2 -
VSNADLMDFKNLLDHLEEK Q13766 32 2 -
VSNGDLMDFKNLLDRLEDK ANF_HORSE 32 2 -
VSNADLMDFKNLLDHLEDK ANF_PIG 31 2 -
VSNADLLDFKNLLDRLEDK ANF_CANFA 30 2 -
VSNTDLMDFKNLLDHLEEK ANF_RAT 31 2 -
VSNADLMDFKNLLDRLEDK ANF_BOVIN 31 2 -
VSNTDLMDFKNLLDHLEEK ANF_MOUSE 31 2 -
MSNADLMDFKNLLDHLEDR ANF_RABIT 32 2 -
MSSADLMDFKDLLDRLEDK Q29130 34 2 -

Motif 3 width=19
Element Seqn Id St Int Rpt
MPLEDEVVPPQVLSEPNEE ANF_HUMAN 51 0 -
MPLEDEVVPPQVLSDPNEE Q13766 51 0 -
MPLEDEVMPPQVLSDQSEE ANF_HORSE 51 0 -
MPLEDEAMPPQVLSEQNEE ANF_PIG 50 0 -
MPLEDEAESPQALSEQNAE ANF_CANFA 49 0 -
MPVEDEVMPPQALSEQTDE ANF_RAT 50 0 -
MPLEDEAVPSQVLSEQNEE ANF_BOVIN 50 0 -
MPVEDEVMPPQALSEQTEE ANF_MOUSE 50 0 -
MPFEDEAVPPQALSEQSDE ANF_RABIT 51 0 -
MPLEDEVAPPQILSEQTDE Q29130 53 0 -

Motif 4 width=18
Element Seqn Id St Int Rpt
AALSPLPEVPPWTGEVSP ANF_HUMAN 72 2 -
AALSPLPEVPPWTGEVSP Q13766 72 2 -
AALSPLPEVPPWTGEVNP ANF_HORSE 72 2 -
APLSPLLEVPPWTGEVNP ANF_PIG 71 2 -
AALSPLPEVPPWTGEVSP ANF_CANFA 70 2 -
AALSSLSEVPPWTGEVNP ANF_RAT 71 2 -
APLSPLSEMPPWMGEVNP ANF_BOVIN 71 2 -
AALSSLPEVPPWTGEVNP ANF_MOUSE 71 2 -
AALSPLPEVPPWTGEVSP ANF_RABIT 72 2 -
AALSPLPEVPPWTGEVSP Q29130 74 2 -

Motif 5 width=17
Element Seqn Id St Int Rpt
RDGGALGRGPWDSSDRS ANF_HUMAN 92 2 -
RDGGALGRGPWDSSDRS Q13766 92 2 -
RDGGALGRGSWDSSDRS ANF_HORSE 92 2 -
RDGGALGRGPWDASDRS ANF_PIG 91 2 -
RDGGALGRSPWDSSDRS ANF_CANFA 90 2 -
RDGGALGRGPWDPSDRS ANF_RAT 91 2 -
REGGVLGRGPWESSDRS ANF_BOVIN 91 2 -
RDGSASRRSPWDPSDRS ANF_MOUSE 91 2 -
RDGEALGRSTWEASERS ANF_RABIT 92 2 -
RDGGALGRSPWDSSERS Q29130 94 2 -

Motif 6 width=19
Element Seqn Id St Int Rpt
ALLKSKLRALLTAPRSLRR ANF_HUMAN 109 0 -
ALLKSKLRALLTAPRSLRR Q13766 109 0 -
ALLKSKLRALLAAPRSLRR ANF_HORSE 109 0 -
ALLKSKLRALLAAPRSLRR ANF_PIG 108 0 -
ALLKSKLRALLAAPRSLRR ANF_CANFA 107 0 -
ALLKSKLRALLAGPRSLRR ANF_RAT 108 0 -
ALLKSKLRALLTAPRSLRR ANF_BOVIN 108 0 -
ALLKSKLRALLAGPRSLRR ANF_MOUSE 108 0 -
ALLKSKLRALLTAPRSLRR ANF_RABIT 109 0 -
ALLKSKLRAMLAAPRSLRR Q29130 111 0 -

Motif 7 width=23
Element Seqn Id St Int Rpt
SSCFGGRMDRIGAQSGLGCNSFR ANF_HUMAN 128 0 -
SSCFGGRMDRIGAQSGLGCNSFR Q13766 128 0 -
SSCFGGRMDRIGAQSGLGCNSFR ANF_HORSE 128 0 -
SSCFGGRMDRIGAQSGLGCNSFR ANF_PIG 127 0 -
SSCFGGRMDRIGAQSGLGCNSFR ANF_CANFA 126 0 -
SSCFGGRIDRIGAQSGLGCNSFR ANF_RAT 127 0 -
SSCFGGRMDRIGAQSGLGCNSFR ANF_BOVIN 127 0 -
SSCFGGRIDRIGAQSGLGCNSFR ANF_MOUSE 127 0 -
SSCFGGRIDRIGAQSGLGCNSFR ANF_RABIT 128 0 -
SSCFGGRMDRIGAQSGLGCNSFR Q29130 130 0 -