| Literature References | 1. INAGAMI, T.
Atrial natriuretic factor.
J.BIOL.CHEM. 264 3043-3046 (1989).
2. SAGNELLA, G.A. AND MCGREGOR, G.A.
Structural and functional features of atrial natriuretic peptides.
TRENDS BIOCHEM.SCI. 11 299-302 (1986).
3. ROSENZWEIG, A. AND SEIDMAN, C.E.
Atrial natriuretic factor and related peptide hormones.
ANNU.REV.BIOCHEMISTRY 60 229-255 (1991).
4. TAKEI, Y., TAKAHASHI, A., WATANABE, T.X., NAKAJIMA, K.
AND SAKAKIBARA, S.
A novel natriuretic peptide isolated from eel cardiac ventricles.
FEBS LETT. 282 317-320 (1991).
5. SCHWEITZ, H., WIGNE, P., MOINIER, D., FRELIN, C. AND LAZDUNSKI, M.
A new member of the natriuretic peptide family is present in the venom of
the green mamba (Dendroaspis angusticeps.
J.BIOL.CHEM. 267 13928-13932 (1992).
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| Documentation | Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an
important role in the control of cardiovascular homeostatis, and sodium
and water balance in general [1-3]. There are different NPs that vary in
length but share a common core. All are processed from a single precursor.
A disulphide bond resident in the C-terminal section is required for full
activity of atriopeptins.
The family of NPs includes structurally-related peptides that elicit
similar pharmacological spectra: amongst these are brain natriuretic
peptide (BNP); C-type natriuretic peptide (CNP); ventricular natriuretic
peptide (VNP) [4]; and green mamba natriuretic peptide (DNP) [5].
ANATPEPTIDE is a 7-element fingerprint that provides a signature for atrial
natriuretic peptides. The fingerprint was derived from an initial alignment
of 8 sequences: the motifs were drawn from conserved regions spanning the
full alignment length - motif 7 spans the C-terminal region encoded by
PROSITE pattern NATRIURETIC_PEPTIDE (PS00263), which includes the two
functionally important cysteines and two conserved glycines, which may be
important for the conformation of the peptides. Two iterations on OWL29.3
were required to reach convergence, at which point a true set comprising
10 sequences was identified. Several partial matches were also found, all
of which are natriuretic peptide fragments.
An update on SPTR37_9f identified a true set of 10 sequences, and 3
partial matches.
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