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PR00710

Identifier
NATPEPTIDES  [View Relations]  [View Alignment]  
Accession
PR00710
No. of Motifs
2
Creation Date
01-JUN-1996  (UPDATE 21-JUN-1999)
Title
Natriuretic peptide family signature
Database References
PRINTS; PR00711 ANATPEPTIDE; PR00712 BNATPEPTIDE; PR00713 CNATPEPTIDE

PROSITE; PS00263 NATRIURETIC_PEPTIDE
BLOCKS; BL00263
INTERPRO; IPR000663
Literature References
1. INAGAMI, T.
Atrial natriuretic factor.
J.BIOL.CHEM. 264 3043-3046 (1989).
 
2. SAGNELLA, G.A. AND MCGREGOR, G.A.
Structural and functional features of atrial natriuretic peptides.
TRENDS BIOCHEM.SCI. 11 299-302 (1986).
 
3. ROSENZWEIG, A. AND SEIDMAN, C.E.
Atrial natriuretic factor and related peptide hormones.
ANNU.REV.BIOCHEMISTRY 60 229-255 (1991).
 
4. TAKEI, Y., TAKAHASHI, A., WATANABE, T.X., NAKAJIMA, K.
AND SAKAKIBARA, S.
A novel natriuretic peptide isolated from eel cardiac ventricles.
FEBS LETT. 282 317-320 (1991).
 
5. SCHWEITZ, H., WIGNE, P., MOINIER, D., FRELIN, C. AND LAZDUNSKI, M.
A new member of the natriuretic peptide family is present in the venom of
the green mamba (Dendroaspis angusticeps). 
J.BIOL.CHEM. 267 13928-13932 (1992). 

Documentation
Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an
important role in the control of cardiovascular homeostatis, and sodium
and water balance in general [1-3]. There are different NPs that vary in
length but share a common core. All are processed from a single precursor.
A disulphide bond resident in the C-terminal section is required for full
activity of atriopeptins.
 
The family of NPs includes structurally-related peptides that elicit 
similar pharmacological spectra: amongst these are brain natriuretic
peptide (BNP); C-type natriuretic peptide (CNP); ventricular natriuretic
peptide (VNP) [4]; and green mamba natriuretic peptide (DNP) [5]. 
 
NATPEPTIDES is a 2-element fingerprint that provides a signature for the
natriuretic peptide family. The fingerprint was derived from an initial
alignment of 21 sequences: the motifs were drawn from the common conserved
C-terminal region, spanning the section encoded by PROSITE pattern
NATRIURETIC_PEPTIDE (PS00263), which includes the two functionally important
cysteines and two conserved glycines, which may be important for the
conformation of the peptides. Two iterations on OWL29.3 were required to
reach convergence, at which point a true set comprising 46 sequences was
identified. 
 
An update on SPTR37_9f identified a true set of 39 sequences.
Summary Information
39 codes involving  2 elements
Composite Feature Index
23939
12
True Positives
ANFB_BOVIN    ANFB_CANFA    ANFB_HUMAN    ANFB_MOUSE    
ANFB_PIG ANFB_RAT ANFC_ANGJA ANFC_BOVIN
ANFC_CHICK ANFC_HUMAN ANFC_MOUSE ANFC_PIG
ANFC_RANCA ANFC_RAT ANFC_SCYCA ANFC_SHEEP
ANFC_SQUAC ANFC_TRISC ANFD_RANCA ANFV_ANGJA
ANF_ANGJA ANF_BOVIN ANF_CANFA ANF_CHICK
ANF_HORSE ANF_HUMAN ANF_MOUSE ANF_PIG
ANF_RABIT ANF_RANCA ANF_RANRI ANF_RAT
DNP_DENAN O46540 O46541 O55086
P79799 Q13766 Q29130
Sequence Titles
ANFB_BOVIN  BRAIN NATRIURETIC PEPTIDE PRECURSOR (BNP) (ALDOSTERONE SECRETION INHIBITORY FACTOR) (ASIF) - BOS TAURUS (BOVINE). 
ANFB_CANFA BRAIN NATRIURETIC PEPTIDE PRECURSOR (BNP) - CANIS FAMILIARIS (DOG).
ANFB_HUMAN BRAIN NATRIURETIC PEPTIDE PRECURSOR (BNP) - HOMO SAPIENS (HUMAN).
ANFB_MOUSE BRAIN NATRIURETIC PEPTIDE PRECURSOR (BNP) - MUS MUSCULUS (MOUSE).
ANFB_PIG BRAIN NATRIURETIC PEPTIDE PRECURSOR (BNP) - SUS SCROFA (PIG).
ANFB_RAT BRAIN NATRIURETIC PEPTIDE PRECURSOR (BNP) (5 KD CARDIAC NATRIURETIC PEPTIDE) (ISO-ANP) - RATTUS NORVEGICUS (RAT).
ANFC_ANGJA C-TYPE NATRIURETIC PEPTIDE PRECURSOR (BNP-LIKE PEPTIDE) - ANGUILLA JAPONICA (JAPANESE EEL).
ANFC_BOVIN C-TYPE NATRIURETIC PEPTIDE PRECURSOR (SVSP15) [CONTAINS: CNP-22; CNP- 29; CNP-53] - BOS TAURUS (BOVINE).
ANFC_CHICK C-TYPE NATRIURETIC PEPTIDE (CNP) - GALLUS GALLUS (CHICKEN).
ANFC_HUMAN C-TYPE NATRIURETIC PEPTIDE PRECURSOR [CONTAINS: CNP-22; CNP-29; CNP- 53] - HOMO SAPIENS (HUMAN).
ANFC_MOUSE C-TYPE NATRIURETIC PEPTIDE PRECURSOR [CONTAINS: CNP-22; CNP-29; CNP- 53] - MUS MUSCULUS (MOUSE).
ANFC_PIG C-TYPE NATRIURETIC PEPTIDE PRECURSOR [CONTAINS: CNP-22; CNP-29; CNP- 53] - SUS SCROFA (PIG).
ANFC_RANCA C-TYPE NATRIURETIC PEPTIDE 1 PRECURSOR (CNP I) - RANA CATESBEIANA (BULL FROG).
ANFC_RAT C-TYPE NATRIURETIC PEPTIDE PRECURSOR [CONTAINS: CNP-22; CNP-29; CNP- 53] - RATTUS NORVEGICUS (RAT).
ANFC_SCYCA C-TYPE NATRIURETIC PEPTIDE (CNP-115) - SCYLIORHINUS CANICULA (SPOTTED DOGFISH) (SPOTTED CATSHARK).
ANFC_SHEEP C-TYPE NATRIURETIC PEPTIDE PRECURSOR [CONTAINS: CNP-22; CNP-29; CNP- 53] - OVIS ARIES (SHEEP).
ANFC_SQUAC C-TYPE NATRIURETIC PEPTIDE PRECURSOR - SQUALUS ACANTHIAS (SPINY DOGFISH).
ANFC_TRISC C-TYPE NATRIURETIC PEPTIDE (CNP-115) - TRIAKIS SCYLLIUM (LEOPARD SHARK) (TRIAKIS SCYLLIA).
ANFD_RANCA C-TYPE NATRIURETIC PEPTIDE 2 PRECURSOR (CNP II) - RANA CATESBEIANA (BULL FROG).
ANFV_ANGJA VENTRICULAR NATRIURETIC PEPTIDE (VNP) - ANGUILLA JAPONICA (JAPANESE EEL).
ANF_ANGJA ATRIAL NATRIURETIC FACTOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) - ANGUILLA JAPONICA (JAPANESE EEL).
ANF_BOVIN ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - BOS TAURUS (BOVINE).
ANF_CANFA ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - CANIS FAMILIARIS (DOG).
ANF_CHICK ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - GALLUS GALLUS (CHICKEN).
ANF_HORSE ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - EQUUS CABALLUS (HORSE).
ANF_HUMAN ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - HOMO SAPIENS (HUMAN).
ANF_MOUSE ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - MUS MUSCULUS (MOUSE).
ANF_PIG ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - SUS SCROFA (PIG).
ANF_RABIT ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) - ORYCTOLAGUS CUNICULUS (RABBIT).
ANF_RANCA ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) - RANA CATESBEIANA (BULL FROG).
ANF_RANRI ATRIAL NATRIURETIC FACTOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) - RANA RIDIBUNDA (LAUGHING FROG) (MARSH FROG).
ANF_RAT ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETIC PEPTIDE) (ANP) (PREPRONATRIODILATIN) [CONTAINS: AURICULINS; ATRIOPEPTINS] - RATTUS NORVEGICUS (RAT).
DNP_DENAN NATRIURETIC PEPTIDE (DNP) - DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
O46540 ATRIAL NATRIURETIC PEPTIDE - OVIS ARIES (SHEEP).
O46541 BRAIN NATRIURETIC PEPTIDE - OVIS ARIES (SHEEP).
O55086 BRAIN NATRIURETIC PEPTIDE - MUS MUSCULUS (MOUSE).
P79799 NATRIURETIC PEPTIDE - MICRURUS CORALLINUS.
Q13766 ATRIAL NATRIURETIC FACTOR PRECURSOR - HOMO SAPIENS (HUMAN).
Q29130 CARDIODILATIN, ATRIAL NATRIURETIC PEPTIDE - TUPAIA BELANGERI.
Scan History
OWL29_3    2  100  NSINGLE    
SPTR37_9f 2 300 NSINGLE
Initial Motifs
Motif 1  width=10
Element Seqn Id St Int Rpt
RSSCFGGRID ANF_MOUSE 126 126 -
RSSCFGGRID ANF_RAT 126 126 -
RSSCFGGRID ANF_RABIT 127 127 -
RSSCFGGRMD ANF_BOVIN 126 126 -
RSSCFGGRMD ANF_CANFA 125 125 -
RSSCFGGRMD ANF_HORSE 127 127 -
RSSCFGGRMD ANF_HUMAN 127 127 -
RSSCFGGRMD ANF_PIG 126 126 -
SKGCFGLKLD ANFC_PIG 107 107 -
SKGCFGLKLD ANFC_HUMAN 107 107 -
SRSCFGLKLD ANFC_SQUAC 116 116 -
DSGCFGRRLD ANFB_PIG 106 106 -
DSGCFGRRLD ANFB_BOVIN 78 78 -
KSGCFGRRLD ANFB_CANFA 115 115 -
SRGCFGVKLD ANFC_SCYCA 96 96 -
SRSCFGVKLD ANFC_CHICK 3 3 -
SRGCFGVKLD ANFC_RANCA 110 110 -
NRGCFGLKLD ANFC_ANGJA 3 3 -
SSSCFGQKID ANFB_RAT 96 96 -
ISSCFGHKID ANFB_MOUSE 96 96 -
GSGCFGRKMD ANFB_HUMAN 109 109 -

Motif 2 width=10
Element Seqn Id St Int Rpt
DRIGAQSGLG ANF_MOUSE 135 -1 -
DRIGAQSGLG ANF_RAT 135 -1 -
DRIGAQSGLG ANF_RABIT 136 -1 -
DRIGAQSGLG ANF_BOVIN 135 -1 -
DRIGAQSGLG ANF_CANFA 134 -1 -
DRIGAQSGLG ANF_HORSE 136 -1 -
DRIGAQSGLG ANF_HUMAN 136 -1 -
DRIGAQSGLG ANF_PIG 135 -1 -
DRIGSMSGLG ANFC_PIG 116 -1 -
DRIGSMSGLG ANFC_HUMAN 116 -1 -
DRIGAMSGLG ANFC_SQUAC 125 -1 -
DRIGSLSGLG ANFB_PIG 115 -1 -
DRIGSLSGLG ANFB_BOVIN 87 -1 -
DRIGSLSGLG ANFB_CANFA 124 -1 -
DRIGAMSGLG ANFC_SCYCA 105 -1 -
DRIGSMSGLG ANFC_CHICK 12 -1 -
DRIGAFSGLG ANFC_RANCA 119 -1 -
DRIGSLSGLG ANFC_ANGJA 12 -1 -
DRIGAVSRLG ANFB_RAT 105 -1 -
DRIGSVSRLG ANFB_MOUSE 105 -1 -
DRISSSSGLG ANFB_HUMAN 118 -1 -
Final Motifs
Motif 1  width=10
Element Seqn Id St Int Rpt
RSSCFGGRID ANF_MOUSE 126 126 -
RSSCFGGRID ANF_RAT 126 126 -
RSSCFGGRID ANF_RABIT 127 127 -
RSSCFGGRMD ANF_BOVIN 126 126 -
RSSCFGGRMD ANF_CANFA 125 125 -
RSSCFGGRMD ANF_HORSE 127 127 -
RSSCFGGRMD ANF_HUMAN 127 127 -
RSSCFGGRMD ANF_PIG 126 126 -
RSSCFGGRMD O46540 126 126 -
RSSCFGGRMD Q13766 127 127 -
RSSCFGGRMD Q29130 129 129 -
SKGCFGLKLD ANFD_RANCA 99 99 -
SKGCFGLKLD ANFC_BOVIN 107 107 -
SKGCFGLKLD ANFC_SHEEP 107 107 -
SKGCFGLKLD ANFC_RAT 107 107 -
SKGCFGLKLD ANFC_PIG 107 107 -
SKGCFGLKLD ANFC_MOUSE 107 107 -
SKGCFGLKLD ANFC_HUMAN 107 107 -
SRSCFGLKLD ANFC_SQUAC 116 116 -
DSGCFGRRLD O46541 104 104 -
DSGCFGRRLD ANFB_PIG 106 106 -
DSGCFGRRLD ANFB_BOVIN 78 78 -
SSPCFGGKLD ANF_ANGJA 4 4 -
KSGCFGRRLD ANFB_CANFA 115 115 -
SRGCFGVKLD ANFC_TRISC 96 96 -
SRGCFGVKLD ANFC_SCYCA 96 96 -
SRSCFGVKLD ANFC_CHICK 3 3 -
SRGCFGVKLD ANFC_RANCA 110 110 -
NRGCFGLKLD ANFC_ANGJA 3 3 -
SSSCFGQKID ANFB_RAT 96 96 -
DSGCFGRRID ANF_CHICK 115 115 -
SSDCFGSRID ANF_RANCA 122 122 -
SSDCFGSRID ANF_RANRI 8 8 -
ISSCFGHKID ANFB_MOUSE 96 96 -
ISSCFGHKID O55086 96 96 -
GSGCFGRKMD ANFB_HUMAN 109 109 -
FNSCFGTRMD ANFV_ANGJA 3 3 -
GDGCFGQRID P79799 83 83 -
YDPCFGHKID DNP_DENAN 4 4 -

Motif 2 width=10
Element Seqn Id St Int Rpt
DRIGAQSGLG ANF_MOUSE 135 -1 -
DRIGAQSGLG ANF_RAT 135 -1 -
DRIGAQSGLG ANF_RABIT 136 -1 -
DRIGAQSGLG ANF_BOVIN 135 -1 -
DRIGAQSGLG ANF_CANFA 134 -1 -
DRIGAQSGLG ANF_HORSE 136 -1 -
DRIGAQSGLG ANF_HUMAN 136 -1 -
DRIGAQSGLG ANF_PIG 135 -1 -
DRIGAQSGLG O46540 135 -1 -
DRIGAQSGLG Q13766 136 -1 -
DRIGAQSGLG Q29130 138 -1 -
DRIGAMSGLG ANFD_RANCA 108 -1 -
DRIGSMSGLG ANFC_BOVIN 116 -1 -
DRIGSMSGLG ANFC_SHEEP 116 -1 -
DRIGSMSGLG ANFC_RAT 116 -1 -
DRIGSMSGLG ANFC_PIG 116 -1 -
DRIGSMSGLG ANFC_MOUSE 116 -1 -
DRIGSMSGLG ANFC_HUMAN 116 -1 -
DRIGAMSGLG ANFC_SQUAC 125 -1 -
DRIGSLSGLG O46541 113 -1 -
DRIGSLSGLG ANFB_PIG 115 -1 -
DRIGSLSGLG ANFB_BOVIN 87 -1 -
DRIGSYSGLG ANF_ANGJA 13 -1 -
DRIGSLSGLG ANFB_CANFA 124 -1 -
DRIGAMSGLG ANFC_TRISC 105 -1 -
DRIGAMSGLG ANFC_SCYCA 105 -1 -
DRIGSMSGLG ANFC_CHICK 12 -1 -
DRIGAFSGLG ANFC_RANCA 119 -1 -
DRIGSLSGLG ANFC_ANGJA 12 -1 -
DRIGAVSRLG ANFB_RAT 105 -1 -
DRIGSLSGMG ANF_CHICK 124 -1 -
DRIGAQSGMG ANF_RANCA 131 -1 -
DRIGAQSGMG ANF_RANRI 17 -1 -
DRIGSVSRLG ANFB_MOUSE 105 -1 -
DRIGSVSRLG O55086 105 -1 -
DRISSSSGLG ANFB_HUMAN 118 -1 -
DRIGSWSGLG ANFV_ANGJA 12 -1 -
DRICNVSGMG P79799 92 -1 -
DRINHVSNLG DNP_DENAN 13 -1 -