Identifier | ADHESNFAMILY  [View Relations]  [View Alignment]  
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Accession | PR00690 |
No. of Motifs | 6 |
Creation Date | 10-APR-1997  (UPDATE 28-JUL-1999) |
Title | Adhesin family signature |
Database References | PRINTS; PR00691 ADHESINB PROSITE; PS00013 PROKAR_LIPOPROTEIN PFAM; PF01297 Lipoprotein_4 INTERPRO; IPR001987 |
Literature References | 1. SAMPSON, J.S., O'CONNOR, S.P., STINSON, A.R., THARPE, J.A. AND RUSSELL, H.
Cloning and nucleotide sequence analysis of psaA, the Streptococcus
pneumoniae gene encoding a 37-kilodalton protein homologous to previously
reported Streptococcus sp. adhesins.
INFECT.IMMUN. 62(1) 319-324 (1994).
2. GANESHKUMAR, N., HANNAM, P.M., KOLENBRANDER, P.E. AND MCBRIDE, B.C.
Nucleotide sequence of a gene coding for a saliva-binding protein (ssaB)
from Streptococcus sanguis 12 and possible role of the protein in
coaggregation with Actinomyces.
INFECT.IMMUN. 59(3) 1093-1099 (1991).
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Documentation | The Streptococcus pneumoniae psaA gene encodes a protein with significant
similarity to previously-reported Streptococcal proteins, SsaB (80%
similarity) and FimA (92.3% similarity), from S.sanguis and S.parasanguis
[1]. These homologues are associated with bacterial adhesion, and PsaA
may play a similar role [1].
The SsaB protein has a putative hydrophobic 19-amino-acid signal sequence
yielding a 32,620-Mr secreted protein [2]. SsaB is hydrophilic and appears
not to have a hydrophobic membrane anchor in its C-terminal region. A high
degree of similarity exists between S.sanguis ssaB and type 1 fimbrial
genes [2]. Comparison of the gene products reveals close similarity of the
two proteins. It is thought that ssaB adhesion may play a role in oral
colonisation by binding either to a receptor on saliva or to a receptor
on Actinomyces.
ADHESNFAMILY is a 6-element fingerprint that provides a signature for
the adhesins and related periplasmic binding proteins. The fingerprint was
derived from an initial alignment of 15 sequences: the motifs were drawn
from short conserved regions spanning the full alignment length. A single
iteration on OWL29.2 was required to reach convergence, no further sequences
being identified beyond the starting set. Two partial matches were found,
YEBL_ECOLI and D908289, both of which match motifs 2 and 3.
An update on SPTR37_9f identified a true set of 15 sequences, and 6
partial matches.
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Summary Information | 15 codes involving 6 elements 0 codes involving 5 elements 2 codes involving 4 elements 0 codes involving 3 elements 4 codes involving 2 elements
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Composite Feature Index | 6 | 15 | 15 | 15 | 15 | 15 | 15 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 2 | 2 | 2 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3 | 3 | 1 | 0 | 0 | | 1 | 2 | 3 | 4 | 5 | 6 |
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True Positives | ADHS_STRGC ADHS_STRPA ADHS_STRPN ADHS_STRSA O34385 P72415 P72538 P96116 Q47723 Q47869 Q53891 Q55280 Q56329 Q56952 Q57449 |
True Positive Partials | |
Sequence Titles | ADHS_STRGC COAGGREGATION-MEDIATING ADHESIN PRECURSOR - STREPTOCOCCUS GORDONII CHALLIS. ADHS_STRPA ADHESIN B PRECURSOR (SALIVA-BINDING PROTEIN) - STREPTOCOCCUS PARASANGUIS. ADHS_STRPN ADHESION PROTEIN PRECURSOR - STREPTOCOCCUS PNEUMONIAE. ADHS_STRSA ADHESIN B PRECURSOR (SALIVA-BINDING PROTEIN) - STREPTOCOCCUS SANGUIS. O34385 YTGA - BACILLUS SUBTILIS. P72415 LIPOPROTEIN - STAPHYLOCOCCUS EPIDERMIDIS. P72538 SURFACE ADHESIN A PRECURSOR - STREPTOCOCCUS PNEUMONIAE. P96116 TROA PRECURSOR - TREPONEMA PALLIDUM. Q47723 ENDOCARDITIS SPECIFIC ANTIGEN - ENTEROCOCCUS FAECALIS (STREPTOCOCCUS FAECALIS). Q47869 EWLA - ERYSIPELOTHRIX RHUSIOPATHIAE. Q53891 SCBA - STREPTOCOCCUS CRISTATUS. Q55280 PERIPLASMIC-BINDING PROTEIN - SYNECHOCYSTIS SP. (STRAIN PCC 6803). Q56329 TROMP1 - TREPONEMA PALLIDUM. Q56952 YFEA - YERSINIA PESTIS. Q57449 HYPOTHETICAL PROTEIN HI0362 PRECURSOR - HAEMOPHILUS INFLUENZAE. O34966 YCDH - BACILLUS SUBTILIS. O83077 ABC TRANSPORTER, PERIPLASMIC BINDING PROTEIN - TREPONEMA PALLIDUM. O67917 ADHESION PROTEIN - AQUIFEX AEOLICUS. O84420 SOLUTE-BINDING PROTEIN - CHLAMYDIA TRACHOMATIS. Q54914 ORF 1 AND ORF2 5' REGION - STREPTOCOCCUS PYOGENES. ZNUA_ECOLI HIGH-AFFINITY ZINC UPTAKE SYSTEM PROTEIN ZNUA PRECURSOR - ESCHERICHIA COLI.
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Scan History | OWL29_2 1 100 NSINGLE SPTR37_9f 2 200 NSINGLE
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Initial Motifs | Motif 1 width=19 Element Seqn Id St Int Rpt KKKVLTTFTVLADMVQNVA S55045 54 54 - KLNVVATNSIIADITKNIA ADHS_STRGC 33 33 - KLKVVTTNSILADITKNIA ADHS_STRPA 32 32 - KLKVVATNSIIADITKNIA ADHS_STRSA 32 32 - KLKVVTTNSILADITKNIA ADHS_STRPN 33 33 - KLKVVATNSIIADITKNIA SPU407861 32 32 - KLAIVTTNSILSDLVKNVG EFU03756 30 30 - KFKVVTTFTVIQDIAQNVA G64063 23 23 - KPLVVTTIGMIADAVKNIA TPU552141 33 33 - KPLVVTTIGMIADAVKNIA TPU16363 43 43 - KLKVVTTNSILYDMVKRVG SEABCTS2 32 32 - KFKVVTTFTIIQDIAQNIA YPU50597 52 52 - KLNVVATNSIIADITKNIA SCU465421 33 33 - KLKVVATNSIIADITKNIA SPU53509 32 32 - KINVVATTTMIKDLVEIIG ERU52850 32 32 - Motif 2 width=14 Element Seqn Id St Int Rpt GKDPHEYEPLPEDV ADHS_STRPA 63 12 - GQDPHKYEPLPEDV ADHS_STRGC 64 12 - GKDPHEYEPLPEDV ADHS_STRSA 63 12 - GQDPHEYEPLPEDV ADHS_STRPN 64 12 - GQDPHEYEPLPEDV SPU53509 63 12 - GQDPHEYEPLPEDV SCU465421 64 12 - GAEIHDYQPTPRDI YPU50597 83 12 - GQDPHEYEVKPKDI SEABCTS2 63 12 - GVDPHLYTATAGDV TPU16363 74 12 - GVDPHLYTATAGDV TPU552141 64 12 - GAEIHEYEPTPKDI G64063 54 12 - GTDPHEYEPLPEDI EFU03756 61 12 - GAEIHGYEPTPSDI S55045 85 12 - GVDPHLYKAKPSDV ERU52850 63 12 - GQDPHDYEPLAEDV SPU407861 63 12 - Motif 3 width=18 Element Seqn Id St Int Rpt IAKASEADILFFNGLNLE EFU03756 74 -1 - IVKAQDADLILYNGMNLE S55045 98 -1 - VKAIQEADVVAFNGVHLE ERU52850 76 -1 - VEWLGNADLILYNGLHLE TPU552141 77 -1 - VEWLGNADLILYNGLHLE TPU16363 87 -1 - IKALTDADVVFYNGLNLE SEABCTS2 76 -1 - IVKAQSADLILWNGMNLE YPU50597 96 -1 - VKKTSQADLIFYNGINLE SCU465421 77 -1 - VKKTSEADLIFYNGINLE SPU53509 76 -1 - VKKTSEADLIFYNGINLE SPU407861 76 -1 - VKKTSKADLIFYNGINLE ADHS_STRGC 77 -1 - VKKTSQADLIFYNGINLE ADHS_STRPN 77 -1 - VKKTSQADLIFYNGINLE ADHS_STRSA 76 -1 - VKKTSQADLIFYNGINLE ADHS_STRPA 76 -1 - IVKAQSADLILWNGLNLE G64063 67 -1 - Motif 4 width=22 Element Seqn Id St Int Rpt IPAEKKMIVTSEGCFKYFSKAY ADHS_STRPN 195 100 - IPAEKKLIVTSEGAFKYFSKAY SPU407861 194 100 - IPAEKKLIVTSEGAFKYFSKAY SPU53509 194 100 - IPGEKKMIVTSEGCFKYFSKAY SCU465421 195 100 - IPAEQRWLVTSEGAFSYLAKDY YPU50597 207 93 - IPKNQRAMMTSEGAFKYFAQQF SEABCTS2 195 101 - LPAERRVLVTAHDAFGYFSRAY TPU16363 198 93 - LPAERRVLVTAHDAFGYFSRAY TPU552141 188 93 - IPEAQRWLVTSEGAFSYLAKDY G64063 178 93 - IPDDKKLLVTSEGAFKYFSKAY EFU03756 192 100 - VPANQRFLVSCEGAFSYLARDY S55045 209 93 - IPEQQRVLVTAHDAFAYFGRYF ERU52850 189 95 - IPEEKKMIVTSEGCFKYFSKAY ADHS_STRSA 194 100 - IPEDKKMIVTSEGCFKYFSKAY ADHS_STRPA 194 100 - IPEEKKMIVTSEGCPKYFSKAY ADHS_STRGC 195 100 - Motif 5 width=19 Element Seqn Id St Int Rpt KIPVVFSESTISDKPAKQV YPU50597 260 31 - KVPSLFVESSVDDRPMKTV SCU465421 248 31 - KVPSLFVESSVDDRPMKTV SPU53509 247 31 - KVPSLFVDSSVDDRPMKTV SPU407861 247 31 - KIKAIYTESSVPKKTIESL ERU52850 242 31 - NVPTIFCESTVSDKGQKQV S55045 262 31 - KAPVLFVETSVDKRSMERV EFU03756 245 31 - KVPSLFVESSVDERPMKTV ADHS_STRPN 248 31 - KVPSLFVESSVDDRPMKTV ADHS_STRSA 247 31 - KVPALFVESSVDERPMKTV ADHS_STRPA 247 31 - KVPSLFVESSVDDRPMKTV ADHS_STRGC 248 31 - NIPVVFSESTISAKPAQQV G64063 231 31 - KLPAIFIESSIPHKNVEAL TPU552141 241 31 - KLPAIFIESSIPHKNVEAL TPU16363 251 31 - HLKHLLVETSVDKKAMQSL SEABCTS2 248 31 - Motif 6 width=20 Element Seqn Id St Int Rpt IYGEVFTDSIGKEGTKGDSY SEABCTS2 274 7 - IGGELFSDAMGDAGTSEGTY TPU552141 272 12 - YGGVLYVDSLSAKNGPVPTY G64063 257 7 - IYDTLFTDSLAKEGTEGDTY EFU03756 271 7 - FGGNLYVDSLSTEEGPVPTF S55045 288 7 - IGGEIYSDSLKEDASYIETY ERU52850 273 12 - IYAQIFTDSIAEQGKEGDSY SPU53509 273 7 - IYAQIFTDSIAEQGKEGDRY SPU407861 273 7 - IHAKIFTDSIADQGEEGDTY ADHS_STRSA 273 7 - IYAKIFTDSIAKEGEKGDSY ADHS_STRPA 273 7 - IYAKIFTDSIAEKGEDGDSY ADHS_STRGC 274 7 - IFAKIFTDSIAKEGEEGDSY ADHS_STRPN 274 7 - IYAKIFTDSVAEKGEEGDSY SCU465421 274 7 - YGGVLYVDSLSGEKGPVPTY YPU50597 286 7 - IGGELFSDAMGDAGTSEGTY TPU16363 282 12 -
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Final Motifs | Motif 1 width=19 Element Seqn Id St Int Rpt KLKVVATNSIIADITKNIA P72538 32 32 - KLKVVTTNSILADITKNIA ADHS_STRPN 33 33 - KLKVVATNSIIADITKNIA ADHS_STRSA 32 32 - KLNVVATNSIIADITKNIA Q53891 33 33 - KLKVVTTNSILADITKNIA ADHS_STRPA 32 32 - KLNVVATNSIIADITKNIA ADHS_STRGC 33 33 - KLAIVTTNSILSDLVKNVG Q47723 30 30 - KPLVVTTIGMIADAVKNIA P96116 33 33 - KPLVVTTIGMIADAVKNIA Q56329 43 43 - KFKVVTTFTIIQDIAQNIA Q56952 52 52 - KLKVVTTNSILYDMVKRVG P72415 32 32 - KFKVVTTFTVIQDIAQNVA Q57449 23 23 - KKKVLTTFTVLADMVQNVA Q55280 54 54 - QLQVTATTSQIADAAENIG O34385 31 31 - KINVVATTTMIKDLVEIIG Q47869 32 32 - Motif 2 width=14 Element Seqn Id St Int Rpt GQDPHEYEPLPEDV P72538 63 12 - GQDPHEYEPLPEDV ADHS_STRPN 64 12 - GKDPHEYEPLPEDV ADHS_STRSA 63 12 - GQDPHEYEPLPEDV Q53891 64 12 - GKDPHEYEPLPEDV ADHS_STRPA 63 12 - GQDPHKYEPLPEDV ADHS_STRGC 64 12 - GTDPHEYEPLPEDI Q47723 61 12 - GVDPHLYTATAGDV P96116 64 12 - GVDPHLYTATAGDV Q56329 74 12 - GAEIHDYQPTPRDI Q56952 83 12 - GQDPHEYEVKPKDI P72415 63 12 - GAEIHEYEPTPKDI Q57449 54 12 - GAEIHGYEPTPSDI Q55280 85 12 - GVDPHLYKASQGDT O34385 62 12 - GVDPHLYKAKPSDV Q47869 63 12 - Motif 3 width=18 Element Seqn Id St Int Rpt VKKTSEADLIFYNGINLE P72538 76 -1 - VKKTSQADLIFYNGINLE ADHS_STRPN 77 -1 - VKKTSQADLIFYNGINLE ADHS_STRSA 76 -1 - VKKTSQADLIFYNGINLE Q53891 77 -1 - VKKTSQADLIFYNGINLE ADHS_STRPA 76 -1 - VKKTSKADLIFYNGINLE ADHS_STRGC 77 -1 - IAKASEADILFFNGLNLE Q47723 74 -1 - VEWLGNADLILYNGLHLE P96116 77 -1 - VEWLGNADLILYNGLHLE Q56329 87 -1 - IVKAQSADLILWNGMNLE Q56952 96 -1 - IKALTDADVVFYNGLNLE P72415 76 -1 - IVKAQSADLILWNGLNLE Q57449 67 -1 - IVKAQDADLILYNGMNLE Q55280 98 -1 - TKKLMSADVVLYSGLHLE O34385 75 -1 - VKAIQEADVVAFNGVHLE Q47869 76 -1 - Motif 4 width=22 Element Seqn Id St Int Rpt IPAEKKLIVTSEGAFKYFSKAY P72538 194 100 - IPAEKKMIVTSEGCFKYFSKAY ADHS_STRPN 195 100 - IPEEKKMIVTSEGCFKYFSKAY ADHS_STRSA 194 100 - IPGEKKMIVTSEGCFKYFSKAY Q53891 195 100 - IPEDKKMIVTSEGCFKYFSKAY ADHS_STRPA 194 100 - IPEEKKMIVTSEGCPKYFSKAY ADHS_STRGC 195 100 - IPDDKKLLVTSEGAFKYFSKAY Q47723 192 100 - LPAERRVLVTAHDAFGYFSRAY P96116 188 93 - LPAERRVLVTAHDAFGYFSRAY Q56329 198 93 - IPAEQRWLVTSEGAFSYLAKDY Q56952 207 93 - IPKNQRAMMTSEGAFKYFAQQF P72415 195 101 - IPEAQRWLVTSEGAFSYLAKDY Q57449 178 93 - VPANQRFLVSCEGAFSYLARDY Q55280 209 93 - IPEKSRVLVTAHDAFAYFGNEY O34385 187 94 - IPEQQRVLVTAHDAFAYFGRYF Q47869 189 95 - Motif 5 width=19 Element Seqn Id St Int Rpt KVPSLFVESSVDDRPMKTV P72538 247 31 - KVPSLFVESSVDERPMKTV ADHS_STRPN 248 31 - KVPSLFVESSVDDRPMKTV ADHS_STRSA 247 31 - KVPSLFVESSVDDRPMKTV Q53891 248 31 - KVPALFVESSVDERPMKTV ADHS_STRPA 247 31 - KVPSLFVESSVDDRPMKTV ADHS_STRGC 248 31 - KAPVLFVETSVDKRSMERV Q47723 245 31 - KLPAIFIESSIPHKNVEAL P96116 241 31 - KLPAIFIESSIPHKNVEAL Q56329 251 31 - KIPVVFSESTISDKPAKQV Q56952 260 31 - HLKHLLVETSVDKKAMQSL P72415 248 31 - NIPVVFSESTISAKPAQQV Q57449 231 31 - NVPTIFCESTVSDKGQKQV Q55280 262 31 - QIKAVFVESSVSEKSINAV O34385 240 31 - KIKAIYTESSVPKKTIESL Q47869 242 31 - Motif 6 width=20 Element Seqn Id St Int Rpt IYAQIFTDSIAEQGKEGDSY P72538 273 7 - IFAKIFTDSIAKEGEEGDSY ADHS_STRPN 274 7 - IHAKIFTDSIADQGEEGDTY ADHS_STRSA 273 7 - IYAKIFTDSVAEKGEEGDSY Q53891 274 7 - IYAKIFTDSIAKEGEKGDSY ADHS_STRPA 273 7 - IYAKIFTDSIAEKGEDGDSY ADHS_STRGC 274 7 - IYDTLFTDSLAKEGTEGDTY Q47723 271 7 - IGGELFSDAMGDAGTSEGTY P96116 272 12 - IGGELFSDAMGDAGTSEGTY Q56329 282 12 - YGGVLYVDSLSGEKGPVPTY Q56952 286 7 - IYGEVFTDSIGKEGTKGDSY P72415 274 7 - YGGVLYVDSLSAKNGPVPTY Q57449 257 7 - FGGNLYVDSLSTEEGPVPTF Q55280 288 7 - IGGQLYSDAMGEKGTKEGTY O34385 271 12 - IGGEIYSDSLKEDASYIETY Q47869 273 12 -
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