Identifier | ACOABINDINGP  [View Relations]  [View Alignment]  
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Accession | PR00689 |
No. of Motifs | 4 |
Creation Date | 10-APR-1997  (UPDATE 07-JUN-1999) |
Title | Acyl-coA-binding protein signature |
Database References | PROSITE; PS00880 ACBP BLOCKS; BL00880 PFAM; PF00887 ACBP INTERPRO; IPR000582 PDB; 2ABD SCOP; 2ABD CATH; 2ABD
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Literature References | 1. MARQUARDT, H., TODARO, G.J. AND SHOYAB, M.
Complete amino acid sequences of bovine and human endozepines. Homology
with rat diazepam binding inhibitor.
J.BIOL.CHEM. 261(21) 9727-9731 (1986).
2. ANDERSEN, K.V. AND POULSEN, F.M.
THREE-DIMENSIONAL STRUCTURE IN SOLUTION OF ACYL-COENZYME A
BINDING PROTEIN FROM BOVINE LIVER.
J.MOL.BIOL. 226(4) 1131-1141 (1992).
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Documentation | Acyl-CoA-binding protein (ACBP) is a small (10 Kd) protein that binds medium-
and long-chain acyl-CoA esters with high affinity, and may act as an intra-
cellular carrier of acyl-CoA esters. ACBP has a number of important
physiological and biochemical functions: it is known as a diazepam binding
inhibitor, as a putative neurotransmitter, as a regulator of insulin
release from pancreatic cells, and as a mediator in corticotropin-dependent
adrenal steroidogenesis [1,2]. It is possible that the protein acts as a
neuropeptide that takes part in the modulation of gamma-aminobutyric
acid-ergic transmission [1].
The structure of ACBP has been deduced by NMR spectroscopy and has been
shown to be a mainly-alpha protein, consisting of 5 short alpha-helices
and 3 connecting beta-strands [2].
ACOABINDINGP is a 4-element fingerprint that provides a signature for
acyl-CoA-binding proteins. The fingerprint was derived from an initial
alignment of 15 sequences: the motifs were drawn from conserved regions
spanning the full alignment length - motif spans helix 1 and most of the
first loop; motif 2 encodes helix 2 and corresponds to the region
encoded by PROSITE pattern ACBP (PS00880); motif 3 spans part of the
second loop, helix 3 and the N-terminal portion of helix 4; and motif 4
spans helix 5. Two iterations on OWL29.2 were required to reach convergence,
at which point a true set comprising 22 sequences was identified.
An update on SPTR37_9f identified a true set of 21 sequences, and 3
partial matches.
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Summary Information | 21 codes involving 4 elements 2 codes involving 3 elements 1 codes involving 2 elements
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Composite Feature Index | |
True Positives | ACBP_ANAPL ACBP_BOVIN ACBP_DROME ACBP_GOSHI ACBP_HUMAN ACBP_MANSE ACBP_MOUSE ACBP_PIG ACBP_RANRI ACBP_RAT ACBP_RICCO ACBP_YEAST ENDR_BOVIN O01805 O22643 O42310 Q09603 Q20507 Q39315 Q92272 Q96496 |
True Positive Partials | |
Sequence Titles | ACBP_ANAPL ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR) (DBI) (ENDOZEPINE) (EP) - ANAS PLATYRHYNCHOS (DOMESTIC DUCK). ACBP_BOVIN ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR) (DBI) (ENDOZEPINE) (EP) - BOS TAURUS (BOVINE). ACBP_DROME ACYL-COA-BINDING PROTEIN HOMOLOG (ACBP) (DIAZEPAM BINDING INHIBITOR HOMOLOG) (DBI) - DROSOPHILA MELANOGASTER (FRUIT FLY). ACBP_GOSHI ACYL-COA-BINDING PROTEIN (ACBP) - GOSSYPIUM HIRSUTUM (UPLAND COTTON). ACBP_HUMAN ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR) (DBI) (ENDOZEPINE) (EP) - HOMO SAPIENS (HUMAN). ACBP_MANSE ACYL-COA-BINDING PROTEIN HOMOLOG (ACBP) (DIAZEPAM BINDING INHIBITOR HOMOLOG) (DBI) - MANDUCA SEXTA (TOBACCO HAWKMOTH) (TOBACCO HORNWORM). ACBP_MOUSE ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR) (DBI) (ENDOZEPINE) (EP) - MUS MUSCULUS (MOUSE). ACBP_PIG ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR) (DBI) (ENDOZEPINE) (EP) [CONTAINS: DBI(32-86)] - SUS SCROFA (PIG). ACBP_RANRI ACYL-COA-BINDING PROTEIN HOMOLOG (ACBP) (DIAZEPAM BINDING INHIBITOR HOMOLOG) (DBI) - RANA RIDIBUNDA (LAUGHING FROG) (MARSH FROG). ACBP_RAT ACYL-COA-BINDING PROTEIN (ACBP) (DIAZEPAM BINDING INHIBITOR) (DBI) (ENDOZEPINE) (EP) - RATTUS NORVEGICUS (RAT). ACBP_RICCO ACYL-COA-BINDING PROTEIN (ACBP) - RICINUS COMMUNIS (CASTOR BEAN). ACBP_YEAST ACYL-COA-BINDING PROTEIN (ACBP) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). ENDR_BOVIN ENDOZEPINE-RELATED PROTEIN PRECURSOR (MEMBRANE-ASSOCIATED DIAZEPAM BINDING INHIBITOR) (MA-DBI) - BOS TAURUS (BOVINE). O01805 SIMILAR TO ACYL-COA-BINDING PROTEIN - CAENORHABDITIS ELEGANS. O22643 ACYL-COA-BINDING PROTEIN - FRITILLARIA AGRESTIS. O42310 ACBP/ECHM - CYPRINUS CARPIO (COMMON CARP). Q09603 HYPOTHETICAL 42.1 KD PROTEIN R06F6.9 IN CHROMOSOME II - CAENORHABDITIS ELEGANS. Q20507 F47B10.7 PROTEIN - CAENORHABDITIS ELEGANS. Q39315 ACYL-COA BINDING PROTEIN - BRASSICA NAPUS (RAPE). Q92272 ACYL-COA-BINDING PROTEIN (ACBP) (ACBP TYPE 2) - SACCHAROMYCES PASTORIANUS (YEAST), AND SACCHAROMYCES MONACENSIS. Q96496 ACYL-COA-BINDING PROTEIN (ACBP) (ACBP TYPE 2) - SACCHAROMYCES PASTORIANUS (YEAST), AND SACCHAROMYCES MONACENSIS. O09035 DIAZEPAM BINDING INHIBITOR-LIKE 5 (ENDOZEPINE-LIKE PEPTIDE) - MUS MUSCULUS (MOUSE). O75521 DBI-RELATED PROTEIN - HOMO SAPIENS (HUMAN). Q20862 SIMILAR TO ACYL-COA-BINDING PROTEIN - CAENORHABDITIS ELEGANS.
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Scan History | OWL29_2 2 100 NSINGLE SPTR37_9f 2 160 NSINGLE
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Initial Motifs | Motif 1 width=16 Element Seqn Id St Int Rpt QADFDEAAEEVKKLKT ACBP_ANAPL 19 19 - QAEFDKAAEEVKRLKT ACBP_MOUSE 2 2 - QADFDKAAEEVKRLKT ACBP_RAT 2 2 - QAEFEKAAEEVRHLKT ACBP_HUMAN 2 2 - QAEFDKAAEEVKHLKT ACBP_BOVIN 2 2 - QAEFEKAAEEVKNLKT ACBP_PIG 2 2 - KEEFEEHAEKVKTLPA GHU35015 4 4 - EAEFDKAAEDVKHLKT A60212 2 2 - QADFEKAQKNLKTLKE CER06F69 26 26 - KEDFEEHAEKVKKLTA S48040 4 4 - QEKFDAAVEIIQKLPK CEF47B106 4 4 - ETRFEAAVKVIQSLPK S80107 62 62 - ETRFEAAVKVIQSLPK ENDR_BOVIN 43 43 - SEQFNAAAEKVKSLTK ACBP_DROME 3 3 - QEQFDQAASNVRNLKS ACBP_MANSE 4 4 - Motif 2 width=19 Element Seqn Id St Int Rpt PSNDDMLILYGLYKQATVG GHU35015 21 1 - PADDEMLYIYSHYKQATVG A60212 19 1 - PDNDVKLQLYGLFKQATAG CER06F69 43 1 - PSNEDLLILYGLYKQATVG S48040 21 1 - TSNDQKLTFYSLFKQASIG CEF47B106 25 5 - PTNEMMLKFYSFYKQATEG S80107 83 5 - PADDEMLFIYSHYKQATVG ACBP_PIG 19 1 - PADEEMLFIYSHYKQATVG ACBP_BOVIN 19 1 - PSDEEMLFIYGHYKQATVG ACBP_HUMAN 19 1 - PTDEEMLFIYSHFKQATVG ACBP_RAT 19 1 - PTDEEMLFIYSHFKQATVG ACBP_MOUSE 19 1 - PTDEELKELYGFYKQATVG ACBP_ANAPL 36 1 - PSDNDLLELYALFKQASAG ACBP_MANSE 21 1 - PSDDEFLQLYALFKQASVG ACBP_DROME 20 1 - PTNEMMLKFYSFYKQATEG ENDR_BOVIN 64 5 - Motif 3 width=16 Element Seqn Id St Int Rpt SRPGMFSMKERAKWDA S48040 44 4 - SRPGMFNMREKYKWDA GHU35015 44 4 - ERPGLLDLRGKXXRDA A60212 42 4 - ERPGILDLKGKAKWDA ACBP_PIG 42 4 - ERPGMLDFKGKAKWDA ACBP_BOVIN 42 4 - ERPGMLDFTGKAKWDA ACBP_HUMAN 42 4 - DRPGLLDLKGKAKWDS ACBP_RAT 42 4 - DRPGLLDLKGKAKWDS ACBP_MOUSE 42 4 - ECPGMLDLKGKAKWEA ACBP_ANAPL 59 4 - NRPGLLDLKGKAKFDA ACBP_MANSE 45 5 - AKPGLLDLKGKAKWEA ACBP_DROME 43 4 - SKPGFWDPVGRYKWDA ENDR_BOVIN 87 4 - SKPGFWDPVGRYKWDA S80107 106 4 - DRPGIFSIIERKKWDS CEF47B106 48 4 - KRPGMMDFVGRAKYDA CER06F69 66 4 - Motif 4 width=18 Element Seqn Id St Int Rpt GKSTDEAMSDYITKVKQL S48040 65 5 - GVSQDEAKERYIKALNDM CEF47B106 69 5 - DMTKEEAMIAYVEEMKKI S80107 127 5 - GTSKEDAMKAYINKVEEL ACBP_PIG 63 5 - GTSKEDAMKAYIDKVEEL ACBP_BOVIN 63 5 - GTSKEDAMKAYINKVEEL ACBP_HUMAN 63 5 - GTSKENAMKTYVEKVEEL ACBP_RAT 63 5 - GTSKESAMKTYVEKVDEL ACBP_MOUSE 63 5 - GISKEDAMNAYISKAKTM ACBP_ANAPL 80 5 - GLSKEDAQKAYIAKVESL ACBP_MANSE 66 5 - GKSSEAAQQEYITFVEGL ACBP_DROME 64 5 - DMTKEEAMIAYVEEMKKI ENDR_BOVIN 108 5 - GQTQDEARANYAKLVGGL CER06F69 87 5 - GKSKEEAMGDYITKVKQL GHU35015 65 5 - KPSDDLDMKAYVNKVEDL A60212 86 28 -
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Final Motifs | Motif 1 width=16 Element Seqn Id St Int Rpt QAEFEKAAEEVKNLKT ACBP_PIG 2 2 - QAEFDKAAEEVKHLKT ACBP_BOVIN 2 2 - QAEFEKAAEEVRHLKT ACBP_HUMAN 2 2 - QADFDKAAEEVKRLKT ACBP_RAT 2 2 - QAEFDKAAEEVKRLKT ACBP_MOUSE 2 2 - KEEFEEHAEKVKTLPA ACBP_GOSHI 4 4 - QADFDEAAEEVKKLKT ACBP_ANAPL 19 19 - QADFDKAAGDVKKLKT ACBP_RANRI 3 3 - KEDFEEHAEKVKKLTA Q39315 4 4 - KEDFEEHAEKAKTLPE ACBP_RICCO 4 4 - SQLFEEKAKAVNELPT ACBP_YEAST 3 3 - SQLFEEKAKAVNELPT Q96496 3 3 - SQLFEEKAKAVNELPT Q92272 3 3 - KEEFEEHAVKAKTLPE O22643 4 4 - QEQFDQAASNVRNLKS ACBP_MANSE 4 4 - TLSFDDAAATVKTLKT O01805 2 2 - SEQFNAAAEKVKSLTK ACBP_DROME 3 3 - QADFEKAQKNLKTLKE Q09603 26 26 - VEEFNAAKEKLGALKK O42310 5 5 - ETRFEAAVKVIQSLPK ENDR_BOVIN 43 43 - QEKFDAAVEIIQKLPK Q20507 4 4 - Motif 2 width=19 Element Seqn Id St Int Rpt PADDEMLFIYSHYKQATVG ACBP_PIG 19 1 - PADEEMLFIYSHYKQATVG ACBP_BOVIN 19 1 - PSDEEMLFIYGHYKQATVG ACBP_HUMAN 19 1 - PTDEEMLFIYSHFKQATVG ACBP_RAT 19 1 - PTDEEMLFIYSHFKQATVG ACBP_MOUSE 19 1 - PSNDDMLILYGLYKQATVG ACBP_GOSHI 21 1 - PTDEELKELYGFYKQATVG ACBP_ANAPL 36 1 - PTDDELKELYGLYKQSTVG ACBP_RANRI 20 1 - PSNEDLLILYGLYKQATVG Q39315 21 1 - TTNENKLILYGLYKQATVG ACBP_RICCO 21 1 - PSTDELLELYALYKQATVG ACBP_YEAST 20 1 - PSTDELLELYGLYKQATVG Q96496 20 1 - PSTDELLELYGLYKQATVG Q92272 20 1 - TSNENKLILYGLYKQSTVG O22643 21 1 - PSDNDLLELYALFKQASAG ACBP_MANSE 21 1 - PSNDELLKLYALFKQGTVG O01805 19 1 - PSDDEFLQLYALFKQASVG ACBP_DROME 20 1 - PDNDVKLQLYGLFKQATAG Q09603 43 1 - PGNEVKLKVYALFKQATQG O42310 22 1 - PTNEMMLKFYSFYKQATEG ENDR_BOVIN 64 5 - TSNDQKLTFYSLFKQASIG Q20507 25 5 - Motif 3 width=16 Element Seqn Id St Int Rpt ERPGILDLKGKAKWDA ACBP_PIG 42 4 - ERPGMLDFKGKAKWDA ACBP_BOVIN 42 4 - ERPGMLDFTGKAKWDA ACBP_HUMAN 42 4 - DRPGLLDLKGKAKWDS ACBP_RAT 42 4 - DRPGLLDLKGKAKWDS ACBP_MOUSE 42 4 - SRPGMFNMREKYKWDA ACBP_GOSHI 44 4 - ECPGMLDLKGKAKWEA ACBP_ANAPL 59 4 - ECPGMLDLKGKAKWDA ACBP_RANRI 43 4 - SRPGMFSMKERAKWDA Q39315 44 4 - SRPGMFNMRDRAKWDA ACBP_RICCO 44 4 - EKPGIFNMKDRYKWEA ACBP_YEAST 43 4 - EKPGIFNMKDRYKWEA Q96496 43 4 - EKPGIFNMKDRYKWEA Q92272 43 4 - GRPGMFSPRERAKWDA O22643 44 4 - NRPGLLDLKGKAKFDA ACBP_MANSE 45 5 - DKPGMFDLKGKAKWSA O01805 42 4 - AKPGLLDLKGKAKWEA ACBP_DROME 43 4 - KRPGMMDFVGRAKYDA Q09603 66 4 - PKPSMLDFVNKAKWDA O42310 45 4 - SKPGFWDPVGRYKWDA ENDR_BOVIN 87 4 - DRPGIFSIIERKKWDS Q20507 48 4 - Motif 4 width=18 Element Seqn Id St Int Rpt GTSKEDAMKAYINKVEEL ACBP_PIG 63 5 - GTSKEDAMKAYIDKVEEL ACBP_BOVIN 63 5 - GTSKEDAMKAYINKVEEL ACBP_HUMAN 63 5 - GTSKENAMKTYVEKVEEL ACBP_RAT 63 5 - GTSKESAMKTYVEKVDEL ACBP_MOUSE 63 5 - GKSKEEAMGDYITKVKQL ACBP_GOSHI 65 5 - GISKEDAMNAYISKAKTM ACBP_ANAPL 80 5 - GLSKEDAMSAYVSKAHEL ACBP_RANRI 64 5 - GKSTDEAMSDYITKVKQL Q39315 65 5 - GKSTEEAMSDYITKVKQL ACBP_RICCO 65 5 - GKSQEDAEKEYIALVDQL ACBP_YEAST 64 5 - GKSQEDAEKEYIAYVDNL Q96496 64 5 - GKSQEDAEKEYIAYVDNL Q92272 64 5 - GKSKEEAMGDYITKVKQL O22643 65 5 - GLSKEDAQKAYIAKVESL ACBP_MANSE 66 5 - GLAKDDAQKAYVALVEEL O01805 63 5 - GKSSEAAQQEYITFVEGL ACBP_DROME 64 5 - GQTQDEARANYAKLVGGL Q09603 87 5 - SVSQEEARQQYVDLISSL O42310 66 5 - DMTKEEAMIAYVEEMKKI ENDR_BOVIN 108 5 - GVSQDEAKERYIKALNDM Q20507 69 5 -
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