| Literature References | 1. MAYO, K.E., CERELLI, G.M., SPIESS, J., RIVIER, J., ROSENFELD, M.G.,
EVANS, R.M. AND VALE, W.
Inhibin A-subunit cDNAs from porcine ovary and human placenta.
PROC.NATL.ACAD.SCI.U.S.A. 83(16) 5849-5853 (1986).
2. THOMPSON, D.A., CRONIN, C.N. AND MARTIN, F.
Genomic cloning and sequence analyses of the bovine alpha-, beta A- and
beta B-inhibin/activin genes. Identification of transcription factor AP-2-
binding sites in the 5'-flanking regions by DNAse I footprinting.
EUR.J.BIOCHEMISTRY 226(3) 751-764 (1994).
3. MASON, A.J., HAYFLICK, J.S., LING, N., ESCH, F., UENO, N., YING, S.Y.,
GUILLEMIN, R., NIALL, H. AND SEEBURG, P.H.
Complementary DNA sequences of ovarian follicular fluid inhibin show
precursor structure and homology with transforming growth factor-beta.
NATURE 318 659-663 (1985).
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| Documentation | Inhibins and activins are dimeric peptide hormones that regulate circulating
levels of follicle-stimulating hormone (FSH) [1,2]. In turn, FSH stimulates
inhibin gene expression in the ovarian follicle [2]; this effect is
probably mediated by cAMP [3]. Inhibin is a heterodimer, linked by one or
more disulphide bonds: inhibin A is a dimer of alpha and beta-A chains;
inhibin B is a dimer of alpha and beta-B; activin A is a dimer of beta-A;
and activin AB is a dimer of beta-A and beta-B. Inhibins belong to a gene
family that also includes transforming growth factor-beta (TGF-beta) [3].
INHIBINBC is a 7-element fingerprint that provides a signature for
inhibin beta-C chains. The fingerprint was derived from an initial
alignment of 2 sequences: the motifs were drawn from conserved regions
spanning the N-terminal half of the alignment. A single iteration on
OWL29.1 was required to reach convergence, no further sequences being
identified beyond the starting set. Two partial matches were found, both
of which are fragments: JC415 is an activin beta-D chain and IHBB_RAT is
an inhibin beta-B chain.
An update on SPTR37_9f identified a true set of 2 sequences, and 3
partial matches.
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