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PR00668

Identifier
GLYCPROTEINC  [View Relations]  [View Alignment]  
Accession
PR00668
No. of Motifs
7
Creation Date
08-APR-1997  (UPDATE 10-JUN-1999)
Title
Glycoprotein C signature
Database References

INTERPRO; IPR001038
Literature References
1. ALLEN, G.P. AND COOGLE, L.D.
Characterization of an equine herpesvirus type 1 gene encoding a
glycoprotein (gp13) with homology to Herpes simplex virus glycoprotein C.
J.VIROL. 62(8) 2850-2858 (1988).

Documentation
Equine herpesvirus glycoprotein 13 (EHV-1 gp13) has the characteristic
features of a membrane-spanning protein: an N-terminal signal sequence;
a hydrophobic membrane anchor region; a charged C-terminal cytoplasmic tail;
and an exterior domain with 9 potential N-glycosylation sites [1]. Sequence
comparisons reveal regions of significant similarity between the C-terminal
domains of EHV-1 gp13 and gC-like glycoproteins of Herpes simplex virus
(gC-1 and gC-2), pseudorabies Herpesvirus (gIII) and Varicella-zoster virus
(gp66). By contrast, the N-termini are much less conserved. Such studies
indicate that EHV-1 gp13 is the structural homologue of Herpes simplex virus
glycoprotein C, and shows that the epitope-containing N-terminal amino acid
sequences of the Herpesvirus gC-like glycoproteins have undergone more
extensive evolutionary divergence than the C-terminal sequences [1].
 
GLYCPROTEINC is a 7-element fingerprint that provides a signature for
glycoprotein C and gC-like proteins. The fingerprint was derived from an
initial alignment of 8 sequences: the motifs were drawn from conserved
regions spanning the C-terminal half of the alignment. Two iterations on
OWL29.2 were required to reach convergence, at which point a true set
comprising 16 sequences was identified. Several partial matches were also
found, all of which are glycoprotein C homologues that fail to make
significant matches with one or more motifs. 
 
An update on SPTR37_9f identified a true set of 17 sequences, and 11
partial matches.
Summary Information
  17 codes involving  7 elements
0 codes involving 6 elements
0 codes involving 5 elements
3 codes involving 4 elements
5 codes involving 3 elements
3 codes involving 2 elements
Composite Feature Index
717171717171717
60000000
50000000
43033030
35005005
23003000
1234567
True Positives
O39258        O90731        Q65549        Q65579        
Q65587 Q65821 Q66044 Q66076
Q87089 Q87090 Q87091 VGLC_HSVBC
VGLC_HSVE4 VGLC_HSVEB VGLC_PRVIF VGLC_VZVD
VGLC_VZVS
True Positive Partials
Codes involving 4 elements
VGLC_HSV23 VGLC_HSV2G VGLC_HSV2H
Codes involving 3 elements
VGLC_HSVMB VGLC_HSVMD VGLC_HSVMG VGLC_HSVMM
VGLC_HSVTH
Codes involving 2 elements
O89242 Q69466 VGLC_HSV1K
Sequence Titles
O39258      COUNTERPART OF HSV-1 GENE UL44 AND VZV GENE 14 - EQUINE HERPESVIRUS 4. 
O90731 GLYCOPROTEIN C - FELINE HERPESVIRUS (FELID HERPESVIRUS 1).
Q65549 GLYCOPROTEIN C - BOVINE HERPESVIRUS 5.
Q65579 GLYCOPROTEIN GC - BOVINE HERPESVIRUS 1.
Q65587 GLYCOPROTEIN GC - BOVINE HERPESVIRUS 5.
Q65821 UL44 - BOVINE HERPESVIRUS 1.
Q66044 GLYCOPROTEIN GC - CAPRINE HERPESVIRUS 1 (GOAT HERPESVIRUS).
Q66076 MEMBRANE GLYCOPROTEIN C - CANINE HERPESVIRUS.
Q87089 GLYCOPROTEIN GIII - PSEUDORABIES VIRUS.
Q87090 GLYCOPROTEIN GIII - PSEUDORABIES VIRUS.
Q87091 GLYCOPROTEIN GIII - PSEUDORABIES VIRUS.
VGLC_HSVBC GLYCOPROTEIN GIII PRECURSOR - BOVINE HERPESVIRUS TYPE 1 (STRAIN COOPER).
VGLC_HSVE4 GLYCOPROTEIN C PRECURSOR (GLYCOPROTEIN 13) - EQUINE HERPESVIRUS TYPE 4 (STRAIN 1942) (EHV-4) (EQUINE HERPESVIRUS TYPE 1 SUBTYPE 2).
VGLC_HSVEB GLYCOPROTEIN C PRECURSOR (GLYCOPROTEIN 13) - EQUINE HERPESVIRUS TYPE 1 (STRAIN AB4P) (EHV-1), AND EQUINE HERPESVIRUS TYPE 1 (STRAIN KENTUCKY D) (EHV-1).
VGLC_PRVIF GLYCOPROTEIN GIII PRECURSOR - PSEUDORABIES VIRUS (STRAIN INDIANA-FUNKHAUSER / BECKER) (PRV).
VGLC_VZVD GLYCOPROTEIN GPV - VARICELLA-ZOSTER VIRUS (STRAIN DUMAS) (VZV).
VGLC_VZVS GLYCOPROTEIN GPV - VARICELLA-ZOSTER VIRUS (STRAIN SCOTT) (VZV).

VGLC_HSV23 GLYCOPROTEIN C PRECURSOR - HERPES SIMPLEX VIRUS (TYPE 2 / STRAIN 333).
VGLC_HSV2G GLYCOPROTEIN C PRECURSOR (GLYCOPROTEIN F) - HERPES SIMPLEX VIRUS (TYPE 2 / STRAIN G).
VGLC_HSV2H GLYCOPROTEIN C PRECURSOR - HERPES SIMPLEX VIRUS (TYPE 2 / STRAIN HG52).

VGLC_HSVMB SECRETORY GLYCOPROTEIN GP57-65 PRECURSOR (A ANTIGEN) (GLYCOPROTEIN A) (GA) - MAREK'S DISEASE HERPESVIRUS (STRAIN BC-1) (MDHV).
VGLC_HSVMD SECRETORY GLYCOPROTEIN GP57-65 PRECURSOR (A ANTIGEN) (GLYCOPROTEIN A) (GA) - MAREK'S DISEASE HERPESVIRUS (STRAIN RB-1B) (MDHV).
VGLC_HSVMG SECRETORY GLYCOPROTEIN GP57-65 PRECURSOR (A ANTIGEN) (GLYCOPROTEIN A) (GA) - MAREK'S DISEASE HERPESVIRUS (STRAIN GA) (MDHV).
VGLC_HSVMM SECRETORY GLYCOPROTEIN GP57-65 PRECURSOR (A ANTIGEN) (GLYCOPROTEIN A) (GA) - MAREK'S DISEASE HERPESVIRUS (STRAIN MD5) (MDHV).
VGLC_HSVTH GLYCOPROTEIN A PRECURSOR (A ANTIGEN) - TURKEY HERPESVIRUS (STRAIN H2).

O89242 GLYCOPROTEIN C - GALLID HERPESVIRUS 1 (SEROTYPE 2).
Q69466 GLYCOPROTEIN C PRECURSOR - HERPES SIMPLEX VIRUS (TYPE 2).
VGLC_HSV1K GLYCOPROTEIN C PRECURSOR - HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN KOS).
Scan History
OWL29_2    2  100  NSINGLE    
SPTR37_9f 2 33 NSINGLE
Initial Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
AVCVVASYFPHNSVKLRW VGLC_HSVE4 254 254 -
ATCVVASYFPHSSVKLRW VGLC_HSVEB 237 237 -
AYCNVSKYYPPHSVRVRW VGLC_VZVD 341 341 -
AVCAVANYFPPRSTKLTW HSVULS 11 11 -
AVCRAAEYYPPRSTRLRW S54264 288 288 -
AYCNVSKYYPPHSVRVRW VGLC_VZVS 372 372 -
AVCRAAEYYPPRSTRLHW VGLC_HSVBC 288 288 -
AVCVVRDYYPRRSVRLRW VGLC_PRVIF 254 254 -

Motif 2 width=23
Element Seqn Id St Int Rpt
FITDAIQEYANGLFSYVSAVRIP VGLC_VZVD 369 10 -
YVTNASSVWVDGLITRISTVSIP VGLC_HSVEB 266 11 -
YVTNASSVWVDGLITRISTVSIP VGLC_HSVE4 283 11 -
YISDTASVWIDGLITRSSVLAIP HSVULS 39 10 -
FVTNSTVADELGRRTRVSVVNVT VGLC_PRVIF 282 10 -
HARDVFTVDDSGLFSRTSVLTLE S54264 316 10 -
HARDVFTVDDSGLFSRTSVLTLE VGLC_HSVBC 316 10 -
FITDAIQEYANGLFSYVSAVRIP VGLC_VZVS 400 10 -

Motif 3 width=18
Element Seqn Id St Int Rpt
PSLRCSIEWYRDEVSFSR VGLC_HSVE4 314 8 -
PNLRCDVSWFQSANMERR S54264 347 8 -
PDIRCDLEWHESPVSYKR HSVULS 70 8 -
PNLRCDVSWFQSANMERR VGLC_HSVBC 347 8 -
PSLRCEAVWYRDSVASQR VGLC_PRVIF 322 17 -
PSLRCSIDWYRDEVSFAR VGLC_HSVEB 297 8 -
PAIQCNVLWIRDGVSNMK VGLC_VZVD 401 9 -
PAIQCNVLWIRDGVSNMK VGLC_VZVS 432 9 -

Motif 4 width=16
Element Seqn Id St Int Rpt
GGEAVCEARCVPEGRV VGLC_HSVBC 385 20 -
DTRAICDVKCVPRDGI HSVULS 108 20 -
DGHIVCTAKCVPRGVV VGLC_VZVS 470 20 -
DGHIVCTAKCVPRGVV VGLC_VZVD 439 20 -
GGEAVCEARCVPEGRV S54264 385 20 -
DGDAVCTAKCVPSTGV VGLC_HSVEB 335 20 -
DGAAVCTAECVPSNGV VGLC_HSVE4 352 20 -
EGFAVCDGLCVPPEAR VGLC_PRVIF 360 20 -

Motif 5 width=20
Element Seqn Id St Int Rpt
GPCIERPGLVNIQSMCDISE HSVULS 146 22 -
GVCAERPGLVNLRGVRLLST VGLC_HSVBC 419 18 -
GACAEHPGLLNVRSARPLSD VGLC_PRVIF 390 14 -
GVCSSHPGLVNMRSSRPLSE VGLC_HSVE4 388 20 -
GVCPSHSGLVNMQSRRPLSE VGLC_HSVEB 371 20 -
GVCDQNKRFVNMQSSCPTSE VGLC_VZVD 474 19 -
GVCDQNKRFVNMQSSCPTSE VGLC_VZVS 505 19 -
GVCAERPGLVNLRGVRLLST S54264 419 18 -

Motif 6 width=20
Element Seqn Id St Int Rpt
ELDGPITYSCHLDGYPKKFP VGLC_VZVD 493 -1 -
ETDGPVSYTCQTIGYPPILP HSVULS 165 -1 -
TTDGPVDYTCTATGYPAPLP S54264 438 -1 -
TTDGPVDYTCTATGYPAPLP VGLC_HSVBC 438 -1 -
DLDGPVDYTCRLEGLPSQLP VGLC_PRVIF 409 -1 -
EENGEREYNCIIEGYPDGLP VGLC_HSVE4 407 -1 -
ELDGPITYSCHLDGYPKKFP VGLC_VZVS 524 -1 -
EENGEREYSCIIEGYPDGLP VGLC_HSVEB 390 -1 -

Motif 7 width=21
Element Seqn Id St Int Rpt
PEFSATATYDASPGLIGSPVL VGLC_HSVBC 457 -1 -
PEFSATATYDASPGLIGSPVL S54264 457 -1 -
PPFSAVYTYDASTYATTFSVV VGLC_VZVS 543 -1 -
PPFSAVYTYDASTYATTFSVV VGLC_VZVD 512 -1 -
PMFSDTVVYDASPIVEDRPVL VGLC_HSVEB 409 -1 -
PMFSDSVVYDASPIVEDMPVL VGLC_HSVE4 426 -1 -
PVFEDTQRYDASPASVSWPVV VGLC_PRVIF 428 -1 -
PGFYDTQVYDASPEIVSESML HSVULS 184 -1 -
Final Motifs
Motif 1  width=18
Element Seqn Id St Int Rpt
AVCRAAEYYPPRSTRLRW Q65579 288 288 -
AVCRAAEYYPPRSTRLHW Q65821 288 288 -
AVCRAAEYYPPRSTRLHW VGLC_HSVBC 288 288 -
AVCRAAEYYPPRSTRLRW Q65587 268 268 -
AVCRAAEYYPPRSTRLRW Q65549 252 252 -
AVCVVRDYYPRRSVRLRW Q87090 253 253 -
AVCVVRDYYPRRSVRLRW Q87091 254 254 -
AVCVVRDYYPRRSVRLRW VGLC_PRVIF 254 254 -
AVCVVRDYYPRRSVRLRW Q87089 254 254 -
AECRAAGYYPPRSTRLRW Q66044 298 298 -
AVCVVASYFPHNSVKLRW O39258 254 254 -
AVCVVASYFPHNSVKLRW VGLC_HSVE4 254 254 -
ATCVVASYFPHSSVKLRW VGLC_HSVEB 237 237 -
AVCAVANYFPPRSTKLTW O90731 309 309 -
AYCNVSKYYPPHSVRVRW VGLC_VZVD 341 341 -
AYCNVSKYYPPHSVRVRW VGLC_VZVS 372 372 -
AICTIANYFPLESTEIFW Q66076 238 238 -

Motif 2 width=23
Element Seqn Id St Int Rpt
HARDVFTVDDSGLFSRTSVLTLE Q65579 316 10 -
HARDVFTVDDSGLFSRTSVLTLE Q65821 316 10 -
HARDVFTVDDSGLFSRTSVLTLE VGLC_HSVBC 316 10 -
HARDVFTVDGTGLFSRTSVLTLA Q65587 296 10 -
HARDVFTVDDSGLFSRTSVLTLE Q65549 280 10 -
FVTNSTVADELGRRTRVSVVNVT Q87090 281 10 -
FVTNSTVADELGRRTRVSVVNVT Q87091 282 10 -
FVTNSTVADELGRRTRVSVVNVT VGLC_PRVIF 282 10 -
FVTNSTVADELGRRTRVSVVNVT Q87089 282 10 -
HARDEFEVSEAGLLSRTSVVTLE Q66044 326 10 -
YVTNASSVWVDGLITRISTVSIP O39258 283 11 -
YVTNASSVWVDGLITRISTVSIP VGLC_HSVE4 283 11 -
YVTNASSVWVDGLITRISTVSIP VGLC_HSVEB 266 11 -
YISDTASVWIDGLITRSSVLAIP O90731 337 10 -
FITDAIQEYANGLFSYVSAVRIP VGLC_VZVD 369 10 -
FITDAIQEYANGLFSYVSAVRIP VGLC_VZVS 400 10 -
YIDETYSVWIDGLITRTSILSLP Q66076 266 10 -

Motif 3 width=18
Element Seqn Id St Int Rpt
PNLRCDVSWFQSANMERR Q65579 347 8 -
PNLRCDVSWFQSANMERR Q65821 347 8 -
PNLRCDVSWFQSANMERR VGLC_HSVBC 347 8 -
PSLRCEVSWFQSADVERR Q65587 327 8 -
PNLRCEVSWFQSADVERR Q65549 311 8 -
PSLRCEAVWYRDSVASQR Q87090 321 17 -
PSLRCEAVWYRDSVASQR Q87091 322 17 -
PSLRCEAVWYRDSVASQR VGLC_PRVIF 322 17 -
PSLRCEAVWYRDSVASQR Q87089 322 17 -
PNLRCEVSWFQSLNMERR Q66044 357 8 -
PSLRCSIEWYRDEVSFSR O39258 314 8 -
PSLRCSIEWYRDEVSFSR VGLC_HSVE4 314 8 -
PSLRCSIDWYRDEVSFAR VGLC_HSVEB 297 8 -
PDIRCDLEWHESPVSYKR O90731 368 8 -
PAIQCNVLWIRDGVSNMK VGLC_VZVD 401 9 -
PAIQCNVLWIRDGVSNMK VGLC_VZVS 432 9 -
PNLRCNVEWYKNSKASKK Q66076 297 8 -

Motif 4 width=16
Element Seqn Id St Int Rpt
GGEAVCEARCVPEGRV Q65579 385 20 -
GGEAVCEARCVPEGRV Q65821 385 20 -
GGEAVCEARCVPEGRV VGLC_HSVBC 385 20 -
GGEAVCEARCVPERVS Q65587 365 20 -
GGEAVCEARCVPERVS Q65549 349 20 -
EGFAVCDGLCVPPEAR Q87090 359 20 -
EGFAVCDGLCVPPEAR Q87091 360 20 -
EGFAVCDGLCVPPEAR VGLC_PRVIF 360 20 -
EGFAVCDGLCVPPEAR Q87089 360 20 -
GGEAVCEARCVPERNV Q66044 395 20 -
DGAAVCTAECVPSNGV O39258 352 20 -
DGAAVCTAECVPSNGV VGLC_HSVE4 352 20 -
DGDAVCTAKCVPSTGV VGLC_HSVEB 335 20 -
DTRAICDVKCVPRDGI O90731 406 20 -
DGHIVCTAKCVPRGVV VGLC_VZVD 439 20 -
DGHIVCTAKCVPRGVV VGLC_VZVS 470 20 -
NGLAICDAKCVSRENN Q66076 335 20 -

Motif 5 width=20
Element Seqn Id St Int Rpt
GVCAERPGLVNLRGVRLLST Q65579 419 18 -
GVCAERPGLVNLRGVRLLST Q65821 419 18 -
GVCAERPGLVNLRGVRLLST VGLC_HSVBC 419 18 -
GVCAERPGLVNMRGVRLLSA Q65587 398 17 -
GVCAERPRLVNMRGVRLLSA Q65549 382 17 -
GACAEHPGLLNVRSARPLSD Q87090 389 14 -
GACAEHPGLLNVRSARPLSD Q87091 390 14 -
GACAEHPGLLNVRSARPLSD VGLC_PRVIF 390 14 -
GACAEHPGLLNVRSARPLSD Q87089 390 14 -
GVCAERPGLVNLRSVRLLSG Q66044 431 20 -
GVCSSHPGLVNMRSSRPLSE O39258 388 20 -
GVCSSHPGLVNMRSSRPLSE VGLC_HSVE4 388 20 -
GVCPSHSGLVNMQSRRPLSE VGLC_HSVEB 371 20 -
GPCIERPGLVNIQSMCDISE O90731 444 22 -
GVCDQNKRFVNMQSSCPTSE VGLC_VZVD 474 19 -
GVCDQNKRFVNMQSSCPTSE VGLC_VZVS 505 19 -
GPCLNHPGLVNIQNKIDISD Q66076 369 18 -

Motif 6 width=20
Element Seqn Id St Int Rpt
TTDGPVDYTCTATGYPAPLP Q65579 438 -1 -
TTDGPVDYTCTATGYPAPLP Q65821 438 -1 -
TTDGPVDYTCTATGYPAPLP VGLC_HSVBC 438 -1 -
AIDGPVDYTCTATGYPAPLP Q65587 417 -1 -
AIDGPVDYTCTATGYPAPLP Q65549 401 -1 -
DLDGPVDYTCRLEGLPSQLP Q87090 408 -1 -
DLDGPVDYTCRLEGLPSQLP Q87091 409 -1 -
DLDGPVDYTCRLEGLPSQLP VGLC_PRVIF 409 -1 -
DLDGPIDYTCRLEGLPSQLP Q87089 409 -1 -
GADGPVAYTCTAAGYPEPLP Q66044 450 -1 -
EENGEREYNCIIEGYPDGLP O39258 407 -1 -
EENGEREYNCIIEGYPDGLP VGLC_HSVE4 407 -1 -
EENGEREYSCIIEGYPDGLP VGLC_HSVEB 390 -1 -
ETDGPVSYTCQTIGYPPILP O90731 463 -1 -
ELDGPITYSCHLDGYPKKFP VGLC_VZVD 493 -1 -
ELDGPITYSCHLDGYPKKFP VGLC_VZVS 524 -1 -
DYDEPVTYKCSIIGYPIIFP Q66076 388 -1 -

Motif 7 width=21
Element Seqn Id St Int Rpt
PEFSATATYDASPGLIGSPVL Q65579 457 -1 -
PEFSATATYDASPGLIGSPVL Q65821 457 -1 -
PEFSATATYDASPGLIGSPVL VGLC_HSVBC 457 -1 -
PEFSATATHDASPGLIGSPVI Q65587 436 -1 -
PEFSATATHDASPSLIGSPVI Q65549 420 -1 -
PVFEDTQRYDASPASVSWPVV Q87090 427 -1 -
PVFEDTQRYDASPASVSWPVV Q87091 428 -1 -
PVFEDTQRYDASPASVSWPVV VGLC_PRVIF 428 -1 -
PVFEDTQRYDASPASVSWPVV Q87089 428 -1 -
PEFSVTETYDASPSAAAGPIL Q66044 469 -1 -
PMFSDSVVYDASPIVEDMPVL O39258 426 -1 -
PMFSDSVVYDASPIVEDMPVL VGLC_HSVE4 426 -1 -
PMFSDTVVYDASPIVEDRPVL VGLC_HSVEB 409 -1 -
PGFYDTQVYDASPEIVSESML O90731 482 -1 -
PPFSAVYTYDASTYATTFSVV VGLC_VZVD 512 -1 -
PPFSAVYTYDASTYATTFSVV VGLC_VZVS 543 -1 -
PNFYDEKVFDASDENVSKSML Q66076 407 -1 -