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PR00654

Identifier
ANGIOTENSNGN  [View Relations]  [View Alignment]  
Accession
PR00654
No. of Motifs
6
Creation Date
25-JAN-1997  (UPDATE 06-JUN-1999)
Title
Angiotensinogen signature
Database References

PROSITE; PS00284 SERPIN
BLOCKS; BL00284
INTERPRO; IPR000227
Literature References
1. OHKUBO, H., KAGEYAMA, R., UJIHARA, M., HIROSE, T., INAYAMA, S.
AND NAKANISHI, S.
Cloning and sequence analysis of cdna for rat angiotensinogen. 
PROC.NATL.ACAD.SCI.U.S.A. 80(8) 2196-2200 (1983).
 
2. WARD K., HATA A., JEUNEMAITRE X., HELIN C., NELSON L., NAMIKAWA C.,
FARRINGTON P.F., OGASAWARA M., SUZUMORI K., TOMODA S., BERREBI, S.,
SASAKI, M., CORVOL, P., LIFTON, R.P. AND LALOUEL, J.M. 
A molecular variant of angiotensinogen associated with preeclampsia. 
NAT.GENET. 4(1) 59-61 (1993).

Documentation
Angiotensinogen [1], is catalytically cleaved by renin to produce angio- 
tensin I in response to lowered blood pressure. Angiotensin converting
enzyme (ACE), subsequently removes a dipeptide to produce angiotensin II,
the physiologically active peptide, which functions in the regulation of
volume and mineral balance of body fluids. Angiotensinogen is synthesised
in the liver and secreted in plasma. The protein belongs to the superfamily
of serine protease inhibitors.
 
Angiotensinogen appears to be associated with a predisposition to essential
hypertension; it is also associated with pregnancy-induced hypertension
(pih) (preeclampsia), a heterogeneous disorder that complicates 5-7% of all
pregnancies and remains a leading cause of maternal, foetal and neonatal
morbidity and mortality [2].
 
ANGIOTENSNGN is a 6-element fingerprint that provides a signature for 
angiotensinogen. The fingerprint was derived from an initial alignment 
of 4 sequences: the motifs were drawn from conserved regions spanning the
N-terminal half of the alignment. A single iteration on OWL29.1 was 
required to reach convergence, no further sequences being identified
beyond the starting set. Two partial matches were found, S78529 and S78530,
both of which are angiotensinogen fragments.
 
An update on SPTR37_9f identified a true set of 4 sequences.
Summary Information
4 codes involving  6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
6444444
5000000
4000000
3000000
2000000
123456
True Positives
ANGT_HUMAN    ANGT_MOUSE    ANGT_RAT      ANGT_SHEEP    
Sequence Titles
ANGT_HUMAN  ANGIOTENSINOGEN PRECURSOR - HOMO SAPIENS (HUMAN). 
ANGT_MOUSE ANGIOTENSINOGEN PRECURSOR - MUS MUSCULUS (MOUSE).
ANGT_RAT ANGIOTENSINOGEN PRECURSOR - RATTUS NORVEGICUS (RAT).
ANGT_SHEEP ANGIOTENSINOGEN PRECURSOR - OVIS ARIES (SHEEP).
Scan History
OWL29_1    1  50   NSINGLE    
SPTR37_9f 2 5 NSINGLE
Initial Motifs
Motif 1  width=21
Element Seqn Id St Int Rpt
CILTWVSLTAGDRVYIHPFHL ANGT_RAT 14 14 -
CILTWVSLTAGDRVYIHPFHL ANGT_MOUSE 14 14 -
CLLAWAGLAAGDRVYIHPFHL ANGT_HUMAN 23 23 -
CLLAWAGLAAGDRVYIHPFHL ANGT_SHEEP 14 14 -

Motif 2 width=25
Element Seqn Id St Int Rpt
KLEAEDRQRAAQVAMIANFMGFRMY ANGT_RAT 85 50 -
KLEDEDRKRAAQVAMIANFVGFRMY ANGT_MOUSE 85 50 -
KLDTEDKLRAAMVGMLANFLGFRIY ANGT_HUMAN 94 50 -
KLEAEDRLRASEVGLLLNFMGFHVY ANGT_SHEEP 85 50 -

Motif 3 width=20
Element Seqn Id St Int Rpt
VLSPPALFGTLVSFYLGSLD ANGT_RAT 123 13 -
ILSPPALFGTLVSFYLGSLD ANGT_MOUSE 123 13 -
VLSPTAVFGTLASLYLGALD ANGT_HUMAN 133 14 -
VFSPVALFSTLTSFYTGALD ANGT_SHEEP 123 13 -

Motif 4 width=22
Element Seqn Id St Int Rpt
CTSRLDGHKVLTALQAVQGLLV ANGT_RAT 161 18 -
CTSRLDGHKVLAALRAVQGLLV ANGT_MOUSE 161 18 -
CTSRLDAHKVLSALQAVQGLLV ANGT_HUMAN 171 18 -
CTSRLDGRKVLSSLQTIQGLLV ANGT_SHEEP 161 18 -

Motif 5 width=21
Element Seqn Id St Int Rpt
FTAPGLRLKQPFVESLGPFTP ANGT_RAT 202 19 -
FTAPGFRLKHSFVQSLALFTP ANGT_MOUSE 202 19 -
FTAPGLHLKQPFVQGLALYTP ANGT_HUMAN 212 19 -
FTAPGLHLKQPFVQGLSSFAP ANGT_SHEEP 202 19 -

Motif 6 width=20
Element Seqn Id St Int Rpt
DSTLFFNTYVHFQGKMRGFS ANGT_RAT 264 41 -
DSTLLFNTYVHFQGTMRGFS ANGT_MOUSE 264 41 -
DSTLAFNTYVHFQGKMKGFS ANGT_HUMAN 273 40 -
DSTLLFNAYVHFQGKMKGFS ANGT_SHEEP 264 41 -
Final Motifs
Motif 1  width=21
Element Seqn Id St Int Rpt
CILTWVSLTAGDRVYIHPFHL ANGT_RAT 14 14 -
CILTWVSLTAGDRVYIHPFHL ANGT_MOUSE 14 14 -
CLLAWAGLAAGDRVYIHPFHL ANGT_HUMAN 23 23 -
CLLAWAGLAAGDRVYIHPFHL ANGT_SHEEP 14 14 -

Motif 2 width=25
Element Seqn Id St Int Rpt
KLEAEDRQRAAQVAMIANFMGFRMY ANGT_RAT 85 50 -
KLEDEDRKRAAQVAMIANFVGFRMY ANGT_MOUSE 85 50 -
KLDTEDKLRAAMVGMLANFLGFRIY ANGT_HUMAN 94 50 -
KLEAEDRLRASEVGLLLNFMGFHVY ANGT_SHEEP 85 50 -

Motif 3 width=20
Element Seqn Id St Int Rpt
VLSPPALFGTLVSFYLGSLD ANGT_RAT 123 13 -
ILSPPALFGTLVSFYLGSLD ANGT_MOUSE 123 13 -
VLSPTAVFGTLASLYLGALD ANGT_HUMAN 133 14 -
VFSPVALFSTLTSFYTGALD ANGT_SHEEP 123 13 -

Motif 4 width=22
Element Seqn Id St Int Rpt
CTSRLDGHKVLTALQAVQGLLV ANGT_RAT 161 18 -
CTSRLDGHKVLAALRAVQGLLV ANGT_MOUSE 161 18 -
CTSRLDAHKVLSALQAVQGLLV ANGT_HUMAN 171 18 -
CTSRLDGRKVLSSLQTIQGLLV ANGT_SHEEP 161 18 -

Motif 5 width=21
Element Seqn Id St Int Rpt
FTAPGLRLKQPFVESLGPFTP ANGT_RAT 202 19 -
FTAPGFRLKHSFVQSLALFTP ANGT_MOUSE 202 19 -
FTAPGLHLKQPFVQGLALYTP ANGT_HUMAN 212 19 -
FTAPGLHLKQPFVQGLSSFAP ANGT_SHEEP 202 19 -

Motif 6 width=20
Element Seqn Id St Int Rpt
DSTLFFNTYVHFQGKMRGFS ANGT_RAT 264 41 -
DSTLLFNTYVHFQGTMRGFS ANGT_MOUSE 264 41 -
DSTLAFNTYVHFQGKMKGFS ANGT_HUMAN 273 40 -
DSTLLFNAYVHFQGKMKGFS ANGT_SHEEP 264 41 -