| Literature References | 1. THATCHER, T.H. AND GOROVSKY, M.A.
Phylogenetic analysis of the core histones H2A, H2B, H3 and H4
NUCLEIC ACIDS RES. 22(2) 174-179 (1994).
2. SULLIVAN, K.F., HECHENBERGER,M. AND MASRI, K.
Human Cenp-A contains a histone H3 related histone fold domain that
is required for targeting to the centromere.
J.CELL BIOL. 127(3) 581-592 (1994).
3. STOLER, S., KEITH, K.C., CURNICK, K.E. AND FITZGERALDHAYES, M.
A mutation in CSE4, an essential gene encoding a novel chromatin-
associated protein in yeast, causes chromosome nondisjunction and
cell-cycle arrest at mitosis.
GENES DEV. 9(5) 573-586 (1995).
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| Documentation | Histone H3 is a small, highly conserved nuclear protein that, together
with 2 molecules each of histones H2A, H2B and H4, forms the eukaryotic
nucleosome core [1]; the nucleosome octamer winds ~146 DNA base-pairs.
Several proteins have been found to contain a C-terminal H3-like domain,
including the mammalian centromeric protein CENP-A (which may act as a core
histone necessary for the assembly of centromeres) [2]; yeast chromatin-
associated protein CSE4 [3]; and C.elegans chromosome III proteins
YL82_CAEEL and YMH3_CAEEL, whose function is unknown.
HISTONEH3 is a 7-element fingerprint that provides a signature for the
H3 histones. The fingerprint was derived from an initial alignment of 16
sequences: the motifs were drawn from short conserved regions spanning
the full alignment length - motifs 1 and 2 span the N-terminal region
encoded by PROSITE pattern HISTONE_H3_1 (PS00322), and motif 4 includes
the central region encoded by PROSITE pattern HISTONE_H3_2 (PS00959). Two
iterations on OWL29.0 were required to reach convergence, at which point
a true set comprising 51 sequences was identified. Several partial matches
were also found: these include the histone H3-related sequences (CSE4_YEAST,
CENA_HUMAN, CENA_BOVIN, YMH3_CAEEL and YL82_CAEEL) and various fragments.
An update on SPTR37_9f identified a true set of 46 sequences, and 16
partial matches.
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| Sequence Titles | H31_HUMAN HISTONE H3.1 - HOMO SAPIENS (HUMAN), BOS TAURUS (BOVINE), AND MUS MUSCULUS (MOUSE).
H31_SCHPO HISTONE H3.1/H3.2 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
H31_TETPY HISTONE H3.1 - TETRAHYMENA PYRIFORMIS, AND TETRAHYMENA THERMOPHILA.
H32_BOVIN HISTONE H3 (H3.2) - BOS TAURUS (BOVINE), MUS MUSCULUS (MOUSE), GALLUS GALLUS (CHICKEN), CAIRINA MOSCHATA (MUSCOVY DUCK), ICTIOBUS BUBALUS (SMALLMOUTH BUFFALO FISH), PORODERMA AFRICANUS (AFRICAN CATFISH) (AFRICAN CATSHARK), XENOPUS LAEVIS (AFRICAN CLAWED FROG), ONCORHYNCHUS MYKISS (RAINBOW TROUT) (SALMO GAIRDNERI), PLATYNEREIS DUMERILII (DUMERIL'S CLAM WORM), DROSOPHILA HYDEI (FRUIT FLY), TIGRIOPUS CALIFORNICUS, CHIRONOMUS THUMMI THUMMI (MIDGE), AND URECHIS CAUPO (INNKEEPER WORM) (SPOONWORM).
H32_MEDSA HISTONE H3.2, MINOR - MEDICAGO SATIVA (ALFALFA), ARABIDOPSIS THALIANA (MOUSE-EAR CRESS), AND LOLIUM TEMULENTUM.
H32_ORYSA HISTONE H3 - ORYZA SATIVA (RICE).
H32_TETPY HISTONE H3.2 - TETRAHYMENA PYRIFORMIS.
H32_XENLA HISTONE H3.2 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
H33_CAEEL HISTONE H3.3 - CAENORHABDITIS ELEGANS.
H33_HUMAN HISTONE H3.3 (H3.B) (H3.3Q) - HOMO SAPIENS (HUMAN), MUS MUSCULUS (MOUSE), RATTUS NORVEGICUS (RAT), ORYCTOLAGUS CUNICULUS (RABBIT), GALLUS GALLUS (CHICKEN), SPISULA SOLIDISSIMA (ATLANTIC SURF-CLAM), DROSOPHILA MELANOGASTER (FRUIT FLY), AND DROSOPHILA HYDEI (FRUIT FLY).
H33_SCHPO HISTONE H3.3 - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
H33_TETTH HISTONE H3.3 (HV2) - TETRAHYMENA THERMOPHILA.
H34_CAIMO HISTONE H3.4 - CAIRINA MOSCHATA (MUSCOVY DUCK).
H34_MOUSE HISTONE H3.4 (EMBRYONIC) - MUS MUSCULUS (MOUSE).
H3_ACRFO HISTONE H3 - ACROPORA FORMOSA (STAGHORN CORAL).
H3_CAEEL HISTONE H3 - CAENORHABDITIS ELEGANS.
H3_CHLRE HISTONE H3 - CHLAMYDOMONAS REINHARDTII.
H3_DROME HISTONE H3 - DROSOPHILA MELANOGASTER (FRUIT FLY).
H3_EMENI HISTONE H3 - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS).
H3_ENCAL HISTONE H3 - ENCEPHALARTOS ALTENSTEINII (ALTENSTEIN'S BREAD TREE) (CYCAD).
H3_MAIZE HISTONE H3 - ZEA MAYS (MAIZE), ORYZA SATIVA (RICE), ARABIDOPSIS THALIANA (MOUSE-EAR CRESS), AND PETROSELINUM CRISPUM (PARSLEY) (PETROSELINUM HORTENSE).
H3_NEUCR HISTONE H3 - NEUROSPORA CRASSA.
H3_PEA HISTONE H3 - PISUM SATIVUM (GARDEN PEA), TRITICUM AESTIVUM (WHEAT), MEDICAGO SATIVA (ALFALFA), AND ONOBRYCHIS VICIIFOLIA (COMMON SAINFOIN).
H3_PSAMI HISTONE H3, EMBRYONIC - PSAMMECHINUS MILIARIS (SAND SEA URCHIN), PARACENTROTUS LIVIDUS (COMMON SEA URCHIN), STRONGYLOCENTROTUS DROEBACHIENSIS (SEA URCHIN), LYTECHINUS PICTUS (PAINTED SEA URCHIN), DERMASTERIAS IMBRICATA (SEA STAR), PISASTER BREVISPINUS (SEA STAR), PISASTER OCHRACEUS (SEA STAR), PYCNOPODIA HELIANTHOIDES (SEA STAR), AND SOLASTER STIMPSONI (SEA STAR).
H3_STRPU HISTONE H3, EMBRYONIC - STRONGYLOCENTROTUS PURPURATUS (PURPLE SEA URCHIN).
H3_VOLCA HISTONE H3 - VOLVOX CARTERI.
H3_YEAST HISTONE H3 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST), AND KLUYVEROMYCES LACTIS (YEAST).
O02648 HISTONE H3 - DROSOPHILA SIMULANS (FRUIT FLY).
O15819 HISTONE H3 - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).
P90543 HISTONE H3 - EUPLOTES CRASSUS.
Q12605 HISTONE H3 - EMERICELLA NIDULANS (ASPERGILLUS NIDULANS).
Q16695 HISTONE H3 - HOMO SAPIENS (HUMAN).
Q27532 W05B10.1 PROTEIN - CAENORHABDITIS ELEGANS.
Q27689 HISTONE H3 - LYTECHINUS PICTUS (PAINTED SEA URCHIN).
Q27718 HISTONE H3 - PLASMODIUM FALCIPARUM.
Q27719 HISTONE H3 - PLASMODIUM FALCIPARUM.
Q27748 HISTONE H3 - PARACENTROTUS LIVIDUS (COMMON SEA URCHIN).
Q27822 HISTONE H3 - TRICHOMONAS VAGINALIS.
Q27866 HISTONE H3 - STRONGYLOCENTROTUS PURPURATUS (PURPLE SEA URCHIN).
Q42681 HISTONE H3 - CHLAMYDOMONAS REINHARDTII.
Q64400 HISTONE H3 - CRICETULUS LONGICAUDATUS (LONG-TAILED HAMSTER) (CHINESE HAMSTER).
Q64528 HISTONE H3 - MUS PAHARI (SHREW MOUSE).
Q92068 HISTONE H3 - GALLUS GALLUS (CHICKEN).
Q92132 HISTONE H3 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q92133 HISTONE H3 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
Q93081 HISTONE H3 - HOMO SAPIENS (HUMAN).
P90541 HISTONE H3 - EUPLOTES CRASSUS.
Q27489 E03A3.3 PROTEIN - CAENORHABDITIS ELEGANS.
Q27490 E03A3.4 PROTEIN - CAENORHABDITIS ELEGANS.
H3_LEIIN HISTONE H3 - LEISHMANIA INFANTUM.
O44009 HISTONE H3 - LEISHMANIA BRAZILIENSIS.
Q19649 SIMILAR TO HISTONE H3 - CAENORHABDITIS ELEGANS.
Q27880 HISTONE H3 - TRYPANOSOMA CRUZI.
YB21_CAEEL HYPOTHETICAL HISTONE 3-LIKE PROTEIN K03A1.1 IN CHROMOSOME X - CAENORHABDITIS ELEGANS.
YMH3_CAEEL HYPOTHETICAL HISTONE 3-LIKE PROTEIN F58A4.3 IN CHROMOSOME III - CAENORHABDITIS ELEGANS.
CENA_HUMAN CENTROMERE PROTEIN A (CENP-A) (CENTROMERE AUTOANTIGEN A) - HOMO SAPIENS (HUMAN).
CENA_MOUSE CENTROMERE PROTEIN A (CENP-A) (CENTROMERE AUTOANTIGEN A) - MUS MUSCULUS (MOUSE).
CSE4_YEAST CHROMATIN ASSIOCIATED PROTEIN CSE4 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
H3_ENTHI HISTONE H3 - ENTAMOEBA HISTOLYTICA.
O45900 W09H1.2 PROTEIN - CAENORHABDITIS ELEGANS.
YL82_CAEEL HYPOTHETICAL HISTONE 3-LIKE PROTEIN F54C8.2 IN CHROMOSOME III - CAENORHABDITIS ELEGANS.
Q92134 HISTONE GENE CLUSTER XLH1 WITH GENES H3, H4, H2B, H2A AND H1B - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
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