| Literature References | 1. DEHOUX, P. AND COSSART, P.
Homologies between salmolysin and some bacterial regulatory proteins.
MOL.MICROBIOL. 15(3) 591-591 (1995).
2. LOMOVSKAYA, O., LEWIS, K. AND MATIN A.
emrR is a negative regulator of the Escherichia coli multidrug resistance
pump emrAB.
J.BACTERIOL. 177(9) 2328-2334 (1995).
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| Documentation | Numerous bacterial transcription regulatory proteins bind DNA via a
helix-turn-helix (HTH) motif. These proteins are very diverse, but for
convenience may be grouped into subfamilies on the basis of sequence
similarity. One such family, marR, groups together a range of proteins,
including emrR, hpcR, hpR, marR, pecS, petP, papX, prsX, ywaE, yxaD and yybA.
HTHMARR is a 4-element fingerprint that provides a signature for the
multiple antibiotic resistance transcriptional regulator (marR) family.
The fingerprint was derived from an initial alignment of 7 sequences: the
motifs were drawn from short conserved regions spanning virtually the
full alignment length, motifs 2 and 3 spanning the region encoded by
PROSITE pattern HTH_MARR_FAMILY (PS011117). Two iterations on OWL28.1
were required to reach convergence, at which point a true set comprising
11 sequences was identified. A single partial match was also found,
BACYACA36, which makes relatively strong matches with motifs 2 and 3.
An update on SPTR37_9f identified a true set of 12 sequences, and 3
partial matches.
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