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PR00508

Identifier
S21N4MTFRASE  [View Relations]  [View Alignment]  
Accession
PR00508
No. of Motifs
5
Creation Date
24-MAY-1995  (UPDATE 30-JUN-1999)
Title
S21 class N4 adenine-specific DNA methyltransferase signature
Database References

PROSITE; PS00093 N4_MTASE
BLOCKS; BL00093
INTERPRO; IPR001091
PDB; 1ADM
SCOP; 1ADM
Literature References
1. CHENG, X.
Structure and function of DNA methyltransferases.
ANNU.REV.BIOPHYS.BIOMOL.STRUCT. 24 293-318 (1995).
 
2. LABAHN, J., GRANZIN, J., SCHLUCKEBIER, G., ROBINSON, D.P., JACK, W.E.,
SCHILDKRAUT, I. AND SAENGER, W.
Three-dimensional structure of the adenine-specific DNA methyltransferase
M.TaqI in complex with the cofactor S-adenosylmethionine.
PROC.NATL.ACAD.SCI.U.S.A. 91 10957-10961 (1994).
 
3. TIMINSKAS, A., BUTKUS, V. AND JANULAITIS, A.
Sequence motifs characteristic for DNA [cytosine-N4] and DNA [adenine-N6]
methyltransferases. Classification of all DNA methyltransferases.
GENE 157 3-11 (1995).
 
4. WILLCOCK, D.F., DRYDEN, D.T. AND MURRAY, N.E.
A mutational analysis of the two motifs common to adenine
methyltransferases.
EMBO J. 13 3902-3908 (1994).

Documentation
In prokaryotes, the major role of DNA methylation is to protect host
DNA against degradation by restriction enzymes. There are 2 major classes
of DNA methyltransferase that differ in the nature of the modifications
they effect [1]. The members of one class (C-MTases) methylate a ring
carbon and form C5-methylcytosine (see PRINTS signature C5METTRFRASE).
Members of the second class (N-MTases) methylate exocyclic nitrogens and
form either N4-methylcytosine (N4-MTases) or N6-methyladenine (N6-MTases).
Both classes of MTase utilise the cofactor S-adenosyl-L-methionine (SAM)
as the methyl donor and are active as monomeric enzymes [1].
 
The structure of N6-MTase TaqI (M.TaqI) has been resolved to 2.4A [2].
The molecule folds into 2 domains: an N-terminal catalytic domain, which
contains the catalytic and cofactor binding sites, and comprises a central
9-stranded beta-sheet, surrounded by 5 helices; and a C-terminal DNA
recognition domain, which is formed by 4 small beta-sheets and 8 alpha-
helices. The N- and C-terminal domains form a cleft that accommodates the
DNA substrate.
 
A classification of N-MTases has been proposed, based on conserved motif
(CM) arrangements [3]. According to this classification, N4-MTases that
have an SPPY motif (CM II) occuring before the FxGxG motif (CM I) are
designated S21 class N4-adenine MTases.
 
S21N4MTFRASE is a 5-element fingerprint that provides a signature for the
S21 class N4-adenine MTases. The fingerprint was derived from an initial
alignment of 7 sequences. The motifs were drawn from the conserved
regions used by Timinskas et al. [3] in their DNA MTase classification:
the motifs correspond to CM II, III, Is and I, respectively - motif 1,
which contains the N-MTase-specific tetrapeptide SPPY (cf. PROSITE pattern
N4_MTASE), is important for methylation; and motif 4, which contains the
pattern FxGxG, forms part of the cofactor (SAM) binding site [4]. Two
iterations on OWL27.1 were required to reach convergence, at which point a
true set comprising 8 sequences was identified. Several partial matches
were also found, all of which are N6-adenine MTases or their homologues.
 
An update on SPTR37_9f identified a true set of 40 sequences, and 22
partial matches.
Summary Information
  40 codes involving  5 elements
7 codes involving 4 elements
10 codes involving 3 elements
5 codes involving 2 elements
Composite Feature Index
54040404040
474773
3754104
241041
12345
True Positives
ML22_LACLC    MT1C_MORBO    MT22_STRPN    MT42_METJA    
MTB2_BACAM MTC1_CITFR MTC9_CITFR MTH1_HAEIN
MTH1_HAEPA MTH3_HAEIN MTHZ_METTF MTM1_METJA
MTM2_MORBO MTMW_METWO MTP2_PROVU MTSM_SERMA
MTX1_XANCC O03956 O24918 O25907
O25920 O25921 O30569 O30570
O52692 O58333 O68556 O68565
O68568 O74053 O74074 O86267
P71366 P94454 P96424 Q38206
Q45489 Q45971 Q46975 YHDJ_ECOLI
True Positive Partials
Codes involving 4 elements
MTR1_RHOSH O24891 O68789 O82897
Q08802 Q56638 T3MO_SALTY
Codes involving 3 elements
MTB1_BACAM MTEC_ENTCL O25040 O25043
O25315 O25922 O51937 O52513
O64360 T3MO_BPP1
Codes involving 2 elements
MTK1_KLEPN P70724 Q58606 Q58843
T3MO_ECOLI
Sequence Titles
ML22_LACLC  MODIFICATION METHYLASE LLADCHI B (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE LLADCHI B) (M.LLADCHI B) (LLAII) - LACTOCOCCUS LACTIS (SUBSP. CREMORIS) (STREPTOCOCCUS CREMORIS). 
MT1C_MORBO MODIFICATION METHYLASE MBOI C (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE MBOI C) (M.MBOI C) - MORAXELLA BOVIS.
MT22_STRPN MODIFICATION METHYLASE DPNII 2 (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 2) (M.DPNII 2) - STREPTOCOCCUS PNEUMONIAE.
MT42_METJA PROBABLE MODIFICATION METHYLASE MJ1498 (EC 2.1.1.113) (N-4 CYTOSINE- SPECIFIC METHYLTRANSFERASE MJ1498) - METHANOCOCCUS JANNASCHII.
MTB2_BACAM MODIFICATION METHYLASE BAMHII (EC 2.1.1.113) (N-4 CYTOSINE- SPECIFIC METHYLTRANSFERASE BAMHII) (M.BAMHII) - BACILLUS AMYLOLIQUEFACIENS.
MTC1_CITFR MODIFICATION METHYLASE CFRBI (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE CFRBI) (M.CFRBI) - CITROBACTER FREUNDII.
MTC9_CITFR MODIFICATION METHYLASE CFR9I (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE CFR9I) (M.CFR9I) - CITROBACTER FREUNDII.
MTH1_HAEIN MODIFICATION METHYLASE HINFI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE HINFI) (M.HINFI) - HAEMOPHILUS INFLUENZAE.
MTH1_HAEPA MODIFICATION METHYLASE HPAI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE HPAI) (M.HPAI) - HAEMOPHILUS PARAINFLUENZAE.
MTH3_HAEIN MODIFICATION METHYLASE HINDIII (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE HINDIII) (M.HINDIII) - HAEMOPHILUS INFLUENZAE.
MTHZ_METTF MODIFICATION METHYLASE MTHZI (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE MTHZI) (M.MTHZI) - METHANOBACTERIUM THERMOFORMICICUM.
MTM1_METJA MODIFICATION METHYLASE MJAI (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE MJAI) (M.MJAI) - METHANOCOCCUS JANNASCHII.
MTM2_MORBO MODIFICATION METHYLASE MBOII (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE MBOII) (M.MBOII) - MORAXELLA BOVIS.
MTMW_METWO MODIFICATION METHYLASE MWOI (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE MWOI) (M.MWOI) - METHANOBACTERIUM WOLFEI.
MTP2_PROVU MODIFICATION METHYLASE PVU II (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE PVU II) (M.PVUII) - PROTEUS VULGARIS.
MTSM_SERMA MODIFICATION METHYLASE SMAI (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE SMAI) (M.SMAI) - SERRATIA MARCESCENS.
MTX1_XANCC MODIFICATION METHYLASE XCYI (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE XCYI) (M.XYCI) - XANTHOMONAS CAMPESTRIS (PV. CYANOPSIDIS).
O03956 DNA ADENINE METHYLTRANSFERASE - BACTERIOPHAGE MX8.
O24918 TYPE II RESTRICTION ENZYME M PROTEIN (HSDM) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25907 ADENINE SPECIFIC DNA METHYLTRANSFERASE (HINFIM) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25920 TYPE IIS RESTRICTION ENZYME M1 PROTEIN (MOD) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25921 TYPE IIS RESTRICTION ENZYME M2 PROTEIN (MOD) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O30569 ADENINE DNA METHYLTRANSFERASE - SINORHIZOBIUM MELILOTI.
O30570 ADENINE DNA METHYLTRANSFERASE - BRUCELLA ABORTUS.
O52692 SCAI METHYLTRANSFERASE - STREPTOMYCES CAESPITOSUS.
O58333 309AA LONG HYPOTHETICAL MODIFICATION METHYLASE - PYROCOCCUS HORIKOSHII.
O68556 BGLI MODIFICATION METHYLTRANSFERASE - BACILLUS SUBTILIS.
O68565 DNA MODIFICATION METHYLTRANSFERASE M.XMAI - XANTHOMONAS CAMPESTRIS.
O68568 DNA MODIFICATION METHYLTRANSFERASE M.XBAI - XANTHOMONAS CAMPESTRIS.
O74053 SITE-SPECIFIC DNA METHYLTRANSFERASE - CENARCHAEUM SYMBIOSUM.
O74074 SITE-SPECIFIC DNA METHYLTRANSFERASE - CENARCHAEUM SYMBIOSUM.
O86267 METHYLASE - LACTOCOCCUS LACTIS.
P71366 TYPE III RESTRICTION-MODIFICATION ECOP15 ENZYME (MOD) - HAEMOPHILUS INFLUENZAE.
P94454 MODIFICATION METHYLASE F5I1 (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE F5I1) (M.F5I1) - BACILLUS STEAROTHERMOPHILUS.
P96424 METHYLASE M.PAC25I - PSEUDOMONAS ALCALIGENES.
Q38206 CYTOSINE METHYLASE - BACTERIOPHAGE HP1.
Q45489 BGLII MODIFICATION METHYLASE - BACILLUS SUBTILIS.
Q45971 ADENINE METHYLTRANSFERASE - CAULOBACTER CRESCENTUS.
Q46975 ECOVIII MODIFICATION METHYLASE - ESCHERICHIA COLI.
YHDJ_ECOLI HYPOTHETICAL ADENINE-SPECIFIC METHYLASE IN FIS-ENVR INTERGENIC REGION (EC 2.1.1.72) (ORF2) - ESCHERICHIA COLI.

MTR1_RHOSH MODIFICATION METHYLASE RSRI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE RSRI) (M.RSRI) - RHODOBACTER SPHAEROIDES (RHODOPSEUDOMONAS SPHAEROIDES).
O24891 ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O68789 ADENINE DNA METHYLTRANSFERASE HOMOLOG - YERSINIA PESTIS.
O82897 HEMAGGLUTININ-ASSOCIATED PROTEIN - ESCHERICHIA COLI.
Q08802 HYPOTHETICAL 25.6 KD PROTEIN IN VLP 3'REGION - VIBRIO CHOLERAE.
Q56638 HAEMAGGLUTININ ASSOCIATED PROTEIN - VIBRIO CHOLERAE.
T3MO_SALTY TYPE III RESTRICTION-MODIFICATION SYSTEM STYLTI ENZYME MOD (EC 2.1.1.72) (STYLTI METHYLTRANSFERASE) - SALMONELLA TYPHIMURIUM.

MTB1_BACAM MODIFICATION METHYLASE BAMHI (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE BAMHI) (M.BAMHI) - BACILLUS AMYLOLIQUEFACIENS.
MTEC_ENTCL MODIFICATION METHYLASE ECAI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE ECAI) (M.ECAI) - ENTEROBACTER CLOACAE.
O25040 ADENINE SPECIFIC DNA METHYLTRANSFERASE (MOD) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25043 ADENINE SPECIFIC DNA METHYLTRANSFERASE (HPAIM) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25315 ADENINE SPECIFIC DNA METHYLTRANSFERASE (MOD) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25922 TYPE III RESTRICTION ENZYME M PROTEIN (MOD) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O51937 TSP45I METHYLTRANSFERASE - THERMUS SP.
O52513 SFII METHYLTRANSFERASE - STREPTOMYCES FIMBRIATUS.
O64360 GP52 - BACTERIOPHAGE N15.
T3MO_BPP1 TYPE III RESTRICTION-MODIFICATION SYSTEM ECOPI ENZYME MOD (EC 2.1.1.72) (ECOPI METHYLTRANSFERASE) - BACTERIOPHAGE P1.

MTK1_KLEPN MODIFICATION METHYLASE KPNI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE KPNI) (M.KPNI) - KLEBSIELLA PNEUMONIAE.
P70724 AATII METHYLASE - ACETOBACTER ACETI.
Q58606 HYPOTHETICAL PROTEIN MJ1209 - METHANOCOCCUS JANNASCHII.
Q58843 HYPOTHETICAL PROTEIN MJ1448 - METHANOCOCCUS JANNASCHII.
T3MO_ECOLI TYPE III RESTRICTION-MODIFICATION SYSTEM ECOP15I ENZYME MOD (EC 2.1.1.72) (ECOP15I METHYLTRANSFERASE) - ESCHERICHIA COLI.
Scan History
OWL27_1    2  30   NSINGLE    
SPTR37_9f 5 100 NSINGLE
Initial Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
SVRCIVTSPPYWGLR MTC9_CITFR 44 44 -
SVRCVVTSPPYWGLR MTX1_XANCC 44 44 -
TIDLTVTSPPYDDLR MTB2_BACAM 9 9 -
IFDCVVTSPPYWGLR MTSM_SERMA 43 43 -
SVNLVFTSPPYYNAK MTC1_CITFR 131 131 -
SINLVVTSPPYPMVE MTHZ_METTF 22 22 -
SISLVMTSPPFALQR MTP2_PROVU 46 46 -

Motif 2 width=21
Element Seqn Id St Int Rpt
IFSEAKRVLTDDGTLWVNIGD MTC9_CITFR 82 23 -
IFAEVKRVLTDDGTLWLNIGD MTX1_XANCC 82 23 -
TAQELYRVTKEGGVVVWVVGD MTB2_BACAM 35 11 -
LFRDVRRTLKDDGTLWLNIGD MTSM_SERMA 81 23 -
VIKECHRVLSEGRFFVINVSP MTC1_CITFR 164 18 -
VWHEVDRVTAPGGVVIINIGD MTHZ_METTF 73 36 -
FAKVVNKKLKPDGSFVVDFGG MTP2_PROVU 79 18 -

Motif 3 width=18
Element Seqn Id St Int Rpt
HFATFPTELIRPCILAST MTC9_CITFR 226 123 -
HFTTFPPELIRPCIHAST MTX1_XANCC 226 123 -
HPAIFPEKLAEDHILSWS MTB2_BACAM 182 126 -
HFAVFPRAMARLCVLAGS MTSM_SERMA 227 125 -
HPATFPYGLAERVIKYYS MTC1_CITFR 305 120 -
RAAAYPFELAYRLINMYS MTHZ_METTF 213 119 -
HPARFPAKLPEFFIRMLT MTP2_PROVU 246 146 -

Motif 4 width=19
Element Seqn Id St Int Rpt
PGDYVLDPFFGSGTVGVVC MTC9_CITFR 245 1 -
PGDYVLDPFFGSGTVGLVC MTX1_XANCC 245 1 -
EGDIVFDPFMGSGTTAKMA MTB2_BACAM 201 1 -
PGGKVLDPFFGSGTTGVVC MTSM_SERMA 246 1 -
KNDVILDPFAGSGTTAKAA MTC1_CITFR 324 1 -
MGDWVLDPFLGTGTTMIAA MTHZ_METTF 232 1 -
PDDLVVDIFGGSNTTGLVA MTP2_PROVU 265 1 -

Motif 5 width=21
Element Seqn Id St Int Rpt
RQYVGIELNPEYVDIAVNRLQ MTC9_CITFR 268 4 -
RQYVGIELNPEYVTLAADRLQ MTX1_XANCC 268 4 -
RKYIGTEISKEYCDIANERLK MTB2_BACAM 224 4 -
RECVGIELNEEYASLAKERIL MTSM_SERMA 269 4 -
RRFVMCEISKQYIDLIIEGTM MTC1_CITFR 347 4 -
RNSIGYELDHNFKDLIESRIN MTHZ_METTF 255 4 -
RKWISFEMKPEYVAASAFRFL MTP2_PROVU 288 4 -
Final Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
SVDLIFADPPYNIGK YHDJ_ECOLI 33 33 -
SIDLIITDPPYNLGK MTH1_HAEPA 21 21 -
SVDVVFADPPYNLQL O30569 39 39 -
SMDMIFADPPYFLSN MT22_STRPN 41 41 -
SVRCIVTSPPYWGLR MTC9_CITFR 44 44 -
SVDLIFADPPYNLQL Q45971 24 24 -
SVRCVVTSPPYWGLR MTX1_XANCC 44 44 -
SVRCVVTSPPYWGLR O68565 44 44 -
SVRCVVTSPPYWGLR P96424 105 105 -
SVDVIFADPPYNLQL O30570 39 39 -
SMDMIFADPPYFLSN ML22_LACLC 41 41 -
SIDLIFADPPYFMQT MTH1_HAEIN 29 29 -
SVDFIFADPPYFMQT O25907 27 27 -
SVDLVVTSPPYNINK Q45489 54 54 -
CIDLIIADPPYVVSK P94454 44 44 -
SIDMIFADPPYFLSN MT1C_MORBO 32 32 -
SVDLIITSPPYFNIK O25921 21 21 -
TIDLTVTSPPYDDLR MTB2_BACAM 9 9 -
IFDCVVTSPPYWGLR MTSM_SERMA 43 43 -
SVQLAVIDPPYNLSK MTM2_MORBO 23 23 -
SVHMVMTSPPYFGLR Q38206 49 49 -
SIALSVWSPPYHVGK O68556 28 28 -
SIHLILSDIPYGISF O86267 22 22 -
QFDLIFADPPYFLSN O24918 38 38 -
TVDVVVTSPPYNIGI MT42_METJA 22 22 -
SVDLAIIDPPYNLKI O25920 22 22 -
SVHLVVTSPPYPMIE MTM1_METJA 27 27 -
SVHLVVTSPPYYNAP O58333 26 26 -
SVNLVFTSPPYYNAK MTC1_CITFR 131 131 -
IFDLTVTSPPYNIGK O52692 69 69 -
RYRLAVTSPPYYGHR O74074 34 34 -
RYRLAVTSPPYYGHR O74053 28 28 -
YAHLILSDIPYGIGA Q46975 32 32 -
SINLVVTSPPYPMVE MTHZ_METTF 22 22 -
EADLVYLDPPFFTNR O68568 26 26 -
SIHAIISDIPYGIDY MTH3_HAEIN 21 21 -
KVKLIYIDPPYNTGN P71366 142 142 -
SISLVMTSPPFALQR MTP2_PROVU 46 46 -
SISVALTSPPYWRQR MTMW_METWO 22 22 -
SVDAIVTDPPYGETA O03956 30 30 -

Motif 2 width=21
Element Seqn Id St Int Rpt
VIAECHRVLKKQGSMYIMNST YHDJ_ECOLI 68 20 -
WLEECYRVLKPHGTIYIFMGM MTH1_HAEPA 56 20 -
WLLACRRVLKPTGTLWVIGSY O30569 88 34 -
WIRLAKEVLKPNGTVWISGSL MT22_STRPN 89 33 -
IFSEAKRVLTDDGTLWVNIGD MTC9_CITFR 82 23 -
WLKAARRVLKDDGAIWVIGSY Q45971 73 34 -
IFAEVKRVLTDDGTLWLNIGD MTX1_XANCC 82 23 -
IFAEVKRVLTDDGTLWLNIGD O68565 82 23 -
IFAEVRRVLTDDGTLWLNIGD P96424 143 23 -
WLLACRRVLKPNGTIWVIGSY O30570 88 34 -
WIRLARLVLKPNGTIWVSGSL ML22_LACLC 89 33 -
WLKECKRILKSTGSIWVIGSF MTH1_HAEIN 78 34 -
WLKECQRILKDNGSICVIGSF O25907 76 34 -
IIEQCHRVLKPSGSIFWQVGT Q45489 86 17 -
WISFAYKVLKPSGSLIVFNDF P94454 89 30 -
WIAQARQLLKDNGTIWISGTH MT1C_MORBO 80 33 -
VWLECYRALKPNGKLCINVPL O25921 71 35 -
TAQELYRVTKEGGVVVWVVGD MTB2_BACAM 35 11 -
LFRDVRRTLKDDGTLWLNIGD MTSM_SERMA 81 23 -
WIDKVLDKLDKDGSLYIFNTP MTM2_MORBO 56 18 -
VAEQLRRVLRPDGSWWLNLGD Q38206 87 23 -
VIALHYPILKPGGFLVINIDD O68556 60 17 -
WAKEWFRVLKPGSSCFIFAGR O86267 92 55 -
WINNAKKALKDTGSLLISGTY O24918 86 33 -
VVKEIKRVLKDDGSFFINVGY MT42_METJA 57 20 -
WIDKMLPKLKDTGSFYIFNTP O25920 55 18 -
VWEEVYRVLVPGGIACINIGD MTM1_METJA 88 46 -
VGKELMRVLQPGRYACFVTQD O58333 60 19 -
VIKECHRVLSEGRFFVINVSP MTC1_CITFR 164 18 -
WMSRVHRATSAGGAFWLNVGY O52692 101 17 -
VFKSCMDLLTDDGSLFIVIGD O74074 73 24 -
VFKSCMDLLTDDGSLFIVIGD O74053 67 24 -
WATEWFRVLKPGASAIIFAGR Q46975 102 55 -
VWHEVDRVTAPGGVVIINIGD MTHZ_METTF 73 36 -
RLREAHRVLKHSGSIFVHCDT O68568 72 31 -
WSNEWFRVLKSGSSVFVFAGR MTH3_HAEIN 90 54 -
RLEIAKTLLADDGVIFVQCDD P71366 177 20 -
FAKVVNKKLKPDGSFVVDFGG MTP2_PROVU 79 18 -
IFRELRAKLKDDGVFFLNIGD MTMW_METWO 60 23 -
WPGLVRPLLKRTGSMWCFGSF O03956 54 9 -

Motif 3 width=18
Element Seqn Id St Int Rpt
HPTQKPEALLKRIILASS YHDJ_ECOLI 195 106 -
HPTQKPEALYERMILASS MTH1_HAEPA 173 96 -
HPTQKPEALLARILMAST O30569 204 95 -
HPTQKPEYLLERIILAST MT22_STRPN 200 90 -
HFATFPTELIRPCILAST MTC9_CITFR 226 123 -
HPTQKPEALLYRVILSTT Q45971 189 95 -
HFTTFPPELIRPCIHAST MTX1_XANCC 226 123 -
HFATFPPELIRPCIHAST O68565 226 123 -
HFATFPPDLIRPCIQAST P96424 287 123 -
HPTQKPEALLARIMMASS O30570 204 95 -
HPTQKPEYILERIILAST ML22_LACLC 200 90 -
HSTQKPESLLYKVILSSS MTH1_HAEIN 193 94 -
HSTQKPEALLKKIILSAT O25907 191 94 -
HPTQYPEDMIERIVLSTT Q45489 221 114 -
HPTQKPVKLIEYLIRIHS P94454 190 80 -
HPTQKPLGLLSRIILSST MT1C_MORBO 190 89 -
HAALMPAELARRLIRLYS O25921 219 127 -
HPAIFPEKLAEDHILSWS MTB2_BACAM 182 126 -
HFAVFPRAMARLCVLAGS MTSM_SERMA 227 125 -
HITPKPRDLIERIIRASS MTM2_MORBO 193 116 -
HFAVYPPELCEVPIKSSC Q38206 268 160 -
HEAKFPLLLPQRLIKLLT O68556 245 164 -
HPTQKPLVLMKALIELTT O86267 231 118 -
HPTQKPLALLVRLLLMAS O24918 196 89 -
HPATFPPKLPEMCIKLHG MT42_METJA 204 126 -
HPSIKPKALIERMIKASS O25920 193 117 -
RTASFPEEIPRRLIRMFS MTM1_METJA 223 114 -
YTAPFPEELAERLIRLYS O58333 199 118 -
HPATFPYGLAERVIKYYS MTC1_CITFR 305 120 -
HPAQFPSAVIERVIKACS O52692 235 113 -
HFAVFPEDLVSRIVKFAT O74074 281 187 -
HFAVFPEDLVSRIVKFAT O74053 275 187 -
HPTQKPVALMKTLIELTT Q46975 241 118 -
RAAAYPFELAYRLINMYS MTHZ_METTF 213 119 -
YPTQKPILLLERIIEIST O68568 215 122 -
HVAQKPLNLMKLLIDLVT MTH3_HAEIN 234 123 -
KNGKKPEALLRRIIDMTT P71366 432 234 -
HPARFPAKLPEFFIRMLT MTP2_PROVU 246 146 -
HTAVFPEKLVSSLLSRCN MTMW_METWO 165 84 -
NETQKPVALVEPLVRNAC O03956 187 112 -

Motif 4 width=19
Element Seqn Id St Int Rpt
PGDIVLDPFAGSFTTGAVA YHDJ_ECOLI 214 1 -
EGDIVLDPFVGSGTLNFVC MTH1_HAEPA 192 1 -
PGDVVLDPFFGSGTTGAVA O30569 223 1 -
EGDYILDPFVGSGTTGVVA MT22_STRPN 219 1 -
PGDYVLDPFFGSGTVGVVC MTC9_CITFR 245 1 -
PGDVILDPFFGVGTTGAAA Q45971 208 1 -
PGDYVLDPFFGSGTVGLVC MTX1_XANCC 245 1 -
PGDYVLDPFFGSGTVGLVC O68565 245 1 -
PGDYVLDPFFGSGTVGLVC P96424 306 1 -
PGDVILDPFFGSGTTGAVA O30570 223 1 -
ENDYILDPFVGSGTTGVVA ML22_LACLC 219 1 -
PNDVVLDPFFGTGTTGAVA MTH1_HAEIN 212 1 -
PKDIILDPFFGTGTTGAVA O25907 210 1 -
PNDIVLDPFIGMGTTASVA Q45489 240 1 -
ENDIILDPFMGSGTTGVAS P94454 209 1 -
KDDLILDPFSGSGTTGIAG MT1C_MORBO 209 1 -
VGDVVLDPFSGSGTTLREA O25921 238 1 -
EGDIVFDPFMGSGTTAKMA MTB2_BACAM 201 1 -
PGGKVLDPFFGSGTTGVVC MTSM_SERMA 246 1 -
PNDLVLDCFMGSGTTAIVA MTM2_MORBO 212 1 -
EPGIVLDPFAGAGTTCLSA Q38206 402 116 -
KGDTVLDCFMGSGTTAVAA O68556 264 1 -
ENQIVLDPFSGSGTTLVAA O86267 250 1 -
ENSLIGDPFSGSSTTGIAA O24918 215 1 -
KTNLVLDPFMGIGSTAIAC MT42_METJA 224 2 -
KNDLILDLFSGSGMTSLVA O25920 212 1 -
IGDTVLDPFLGTGTTVKAA MTM1_METJA 242 1 -
VGETVLDPFLGSGTTCVVS O58333 218 1 -
KNDVILDPFAGSGTTAKAA MTC1_CITFR 324 1 -
SDGVILDPFLGSGTTSLTA O52692 254 1 -
EGDYVLDPFAGRGTTGIVS O74074 300 1 -
EGDYVLDPFAGRGTTGIVS O74053 294 1 -
KGQLVIDPFSGSGSTLVAA Q46975 260 1 -
MGDWVLDPFLGTGTTMIAA MTHZ_METTF 232 1 -
PGDFIVDPFCGSGTTLVAA O68568 234 1 -
EEQIVLDPFAGSGTTLLAA MTH3_HAEIN 253 1 -
EGDIVLDYHLGSGTTAAVA P71366 451 1 -
PDDLVVDIFGGSNTTGLVA MTP2_PROVU 265 1 -
DGDYILDPFAGTGTTGAVV MTMW_METWO 185 2 -
PGGLVADFFAGSGSTALAC O03956 206 1 -

Motif 5 width=21
Element Seqn Id St Int Rpt
RKFIGIEINSEYIKMGLRRLD YHDJ_ECOLI 237 4 -
RSGIGIDINKEYIEMAKERLD MTH1_HAEPA 215 4 -
RHFVGIEREQDYIDAAAERIA O30569 246 4 -
RRFIGIDAEKEYLKIARKRLE MT22_STRPN 242 4 -
RQYVGIELNPEYVDIAVNRLQ MTC9_CITFR 268 4 -
RKFIGIEREAEDLEHAKARIA Q45971 231 4 -
RQYVGIELNPEYVTLAADRLQ MTX1_XANCC 268 4 -
RQYVGIELNPEYVTLAADRLQ O68565 268 4 -
RQYVGIELNPEYVALAADRLQ P96424 329 4 -
RHFVGIEREQPYIDAATARIN O30570 246 4 -
RKFIGIDSEKEYLKIAKKRLN ML22_LACLC 242 4 -
RNYIGIEREQKYIDVAEKRLR MTH1_HAEIN 235 4 -
RYFIGIEKDSFYIKEAAKRLN O25907 233 4 -
RYFYGAEIEKEYVDIAYQILS Q45489 263 4 -
RNFIGFEINEEYVQIANERIK P94454 232 4 -
RNYIGIEQELEFLELSKRRYH MT1C_MORBO 232 4 -
RNFIGYELYENYKPLIEQKLG O25921 261 4 -
RKYIGTEISKEYCDIANERLK MTB2_BACAM 224 4 -
RECVGIELNEEYASLAKERIL MTSM_SERMA 269 4 -
RNFIGCDMNAEYVNQANFVLN MTM2_MORBO 235 4 -
RRFLGVDLNPEYVAMAQKRVG Q38206 425 4 -
RNFIGIEKEPKYIQLSNKNVE O68556 287 4 -
RHYLGFEIDKDYYNTSLNRLN O86267 273 4 -
REFIGIEKESEFIKISMDRKI O24918 238 4 -
IDYIGFEIDEYYCRVAEERIK MT42_METJA 247 4 -
RNFIGCESHAEYVHGSLEMFR O25920 235 4 -
RNSIGYEIDKSLKPIIEEKIG MTM1_METJA 265 4 -
RNCIGYEIDLELREIIEERLG O58333 241 4 -
RRFVMCEISKQYIDLIIEGTM MTC1_CITFR 347 4 -
RCSVGIEIREDYLDIAVGRLE O52692 277 4 -
RGFTGIDLYPANVARARRNVQ O74074 323 4 -
RGFTGIDLYPANVDRTRRNVK O74053 317 4 -
RDYIGFEINPTYVETSIKRLN Q46975 283 4 -
RNSIGYELDHNFKDLIESRIN MTHZ_METTF 255 4 -
RRAFGIDTSREAVALANRRIE O68568 257 4 -
RHFIGYEKNNGIYNIAVNRLG MTH3_HAEIN 276 4 -
RQYIGIEQMDYIETLAVERLK P71366 474 4 -
RKWISFEMKPEYVAASAFRFL MTP2_PROVU 288 4 -
LNVILIEKGKKFLDIITERTG MTMW_METWO 215 11 -
RRFIGCDIREAQCEAAARELS O03956 229 4 -