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PR00507

Identifier
N12N6MTFRASE  [View Relations]  [View Alignment]  
Accession
PR00507
No. of Motifs
4
Creation Date
31-MAY-1996  (UPDATE 30-JUN-1999)
Title
N12 class N6 adenine-specific DNA methyltransferase signature
Database References

PROSITE; PS00092 N6_MTASE
BLOCKS; BL00092
INTERPRO; IPR002296
PDB; 1ADM
SCOP; 1ADM
Literature References
1. CHENG, X.
Structure and function of DNA methyltransferases.
ANNU.REV.BIOPHYS.BIOMOL.STRUCT. 24 293-318 (1995).
 
2. LABAHN, J., GRANZIN, J., SCHLUCKEBIER, G., ROBINSON, D.P., JACK, W.E.,
SCHILDKRAUT, I. AND SAENGER, W.
Three-dimensional structure of the adenine-specific DNA methyltransferase
M.TaqI in complex with the cofactor S-adenosylmethionine.
PROC.NATL.ACAD.SCI.U.S.A. 91 10957-10961 (1994).
 
3. TIMINSKAS, A., BUTKUS, V. AND JANULAITIS, A.
Sequence motifs characteristic for DNA [cytosine-N4] and DNA [adenine-N6]
methyltransferases. Classification of all DNA methyltransferases.
GENE 157 3-11 (1995).
 
4. WILLCOCK, D.F., DRYDEN, D.T. AND MURRAY, N.E.
A mutational analysis of the two motifs common to adenine
methyltransferases.
EMBO J. 13 3902-3908 (1994).

Documentation
In prokaryotes, the major role of DNA methylation is to protect host
DNA against degradation by restriction enzymes. There are 2 major classes
of DNA methyltransferase that differ in the nature of the modifications
they effect [1]. The members of one class (C-MTases) methylate a ring
carbon and form C5-methylcytosine (see PRINTS signature C5METTRFRASE).
Members of the second class (N-MTases) methylate exocyclic nitrogens and
form either N4-methylcytosine (N4-MTases) or N6-methyladenine (N6-MTases).
Both classes of MTase utilise the cofactor S-adenosyl-L-methionine (SAM)
as the methyl donor and are active as monomeric enzymes [1].
 
The structure of N6-MTase TaqI (M.TaqI) has been resolved to 2.4A [2].
The molecule folds into 2 domains: an N-terminal catalytic domain, which
contains the catalytic and cofactor binding sites, and comprises a central
9-stranded beta-sheet, surrounded by 5 helices; and a C-terminal DNA
recognition domain, which is formed by 4 small beta-sheets and 8 alpha-
helices. The N- and C-terminal domains form a cleft that accommodates the
DNA substrate.
 
A classification of N-MTases has been proposed, based on conserved motif
(CM) arrangements [3]. According to this classification, N6-MTases that
have an NPPY motif (CM II) occuring after the FxGxG motif (CM I) are
designated N12 class N6-adenine MTases.
 
N12N6MTFRASE is a 4-element fingerprint that provides a signature for the
N12 class N6-adenine MTases. The fingerprint was derived from an initial
alignment of 15 sequences. The motifs were drawn from some of the conserved
regions used by Timinskas et al. [3] in their DNA MTase classification:
the motifs correspond to CM Is, I, II and III, respectively - motif 2,
which contains the pattern Pxx(AG)xG, forms part of the cofactor (SAM)
binding site (loop beta 1 - helix A in the M.TaqI structure); motif 3, 
which contains the N-MTase-specific tetrapeptide NPP(FWY) (cf. PROSITE
pattern N6_MTASE), is important for methylation [4] (loop beta 4 - helix D);
and motif 4 corresponds to helix D and strand 5. Four iterations on OWL28.0
were required to reach convergence, at which point a true set comprising 31
sequences was identified. Three partial matches were also found: G64114 is
a Haemophilus influenzae MTase M.EcoR124/3 (named by homology with the
E.coli enzyme) that lacks motif 3; and S49395 (Mycoplasma pulmonis M.HsdM1)
and MAMAMIRM (Microbacterium ammoniaphilum M.MamI) are N12 class N6-adenine
MTases that lack motif 4.
 
An update on SPTR37_9f identified a true set of 64 sequences, and 25
partial matches.
Summary Information
  64 codes involving  4 elements
8 codes involving 3 elements
17 codes involving 2 elements
Composite Feature Index
464646464
36882
2212146
1234
True Positives
MT57_ECOLI    MTA1_ACICA    MTB1_BACST    MTB3_BACAR    
MTBB_BACSU MTC3_CHVN1 MTHC_HAEIN MTHD_HAEIN
MTP7_PSEAE MTPS_PROST MTR1_CHVN6 MTT8_THETH
MTTA_THEAQ MTV1_BACST MTV1_VIBS3 O25210
O25223 O25521 O25568 O25953
O26046 O27025 O33298 O34139
O37396 O37397 O50667 O50698
O52273 O54431 O68168 O82906
O85299 O85862 P71445 P72289
P72417 P72418 P75436 P95510
P95687 P95732 P96188 P96868
Q09050 Q09051 Q47163 Q47282
Q53293 Q53609 Q56238 Q56752
Q56788 Q57168 Q96717 Q96719
T1M1_ECOLI T1M_ECOLI T1M_SALPO T1M_SALTY
T257_ECOLI T4BA_BACCO YY02_METJA YZ42_METJA
True Positive Partials
Codes involving 3 elements
MTM1_MICAM O25380 O25908 O30381
Q12463 Q50358 Y724_METTH YC20_METJA
Codes involving 2 elements
O24895 O28105 O52000 O52001
O52711 O53069 O58378 O66904
P70986 P95799 Q52611 Q58606
Y438_METJA Y710_METJA YJJT_ECOLI YPSC_BACSU
YTXK_BACSU
Sequence Titles
MT57_ECOLI  MODIFICATION METHYLASE ECO57I (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE ECO57I) (M.ECO57I) - ESCHERICHIA COLI. 
MTA1_ACICA MODIFICATION METHYLASE ACCI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE ACCI) (M.ACCI) - ACINETOBACTER CALCOACETICUS.
MTB1_BACST MODIFICATION METHYLASE BSECI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE BSECI) (M.BSECI) - BACILLUS STEAROTHERMOPHILUS.
MTB3_BACAR MODIFICATION METHYLASE BANIII (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE BANIII) (M.BANIII) - BACILLUS ANEURINOLYTICUS.
MTBB_BACSU MODIFICATION METHYLASE BSUBI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE BSUBI) (M.BSUBI) - BACILLUS SUBTILIS.
MTC3_CHVN1 MODIFICATION METHYLASE CVIBIII (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE CVIBIII) (M.CVIBIII) - CHLORELLA VIRUS NC-1A (CV-NC1A).
MTHC_HAEIN MODIFICATION METHYLASE HINCII (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE HINCII) (M.HINCII) - HAEMOPHILUS INFLUENZAE.
MTHD_HAEIN PROBABLE MODIFICATION METHYLASE HINDII (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE HINDII) (M.HINDII) - HAEMOPHILUS INFLUENZAE.
MTP7_PSEAE MODIFICATION METHYLASE PAER7I (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE PAER7I) (M.PAER7I) - PSEUDOMONAS AERUGINOSA.
MTPS_PROST MODIFICATION METHYLASE PSTI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE PSTI) (M.PSTI) - PROVIDENCIA STUARTII.
MTR1_CHVN6 MODIFICATION METHYLASE CVIRI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE CVIRI) (M.CVIRI) - CHLORELLA VIRUS NC-64A (CV-NC64A) (CHLORELLA VIRUS XZ-6E).
MTT8_THETH MODIFICATION METHYLASE TTHHB8I (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE TTHHB8I) (M.TTHHB8I) - THERMUS AQUATICUS (SUBSP. THERMOPHILUS).
MTTA_THEAQ MODIFICATION METHYLASE TAQI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE TAQI) (M.TAQI) - THERMUS AQUATICUS.
MTV1_BACST MODIFICATION METHYLASE BSTVI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE BSTVI) (M.BSTVI) - BACILLUS STEAROTHERMOPHILUS.
MTV1_VIBS3 MODIFICATION METHYLASE VSPI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE VSPI) (M.VSPI) - VIBRIO SP. (STRAIN 343).
O25210 TYPE I RESTRICTION ENZYME M PROTEIN (HSDM) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25223 ADENINE SPECIFIC DNA METHYLTRANSFERASE (VSPIM) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25521 TYPE I RESTRICTION ENZYME M PROTEIN (HSDM) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25568 ADENINE SPECIFIC DNA METHYLTRANSFERASE (HINDIIM) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25953 TYPE I RESTRICTION ENZYME M PROTEIN (HSDM) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O26046 TYPE IIS RESTRICTION ENZYME R AND M PROTEIN (ECO57IR) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O27025 TYPE I RESTRICTION MODIFICATION ENZYME, SUBUNIT M - METHANOBACTERIUM THERMOAUTOTROPHICUM.
O33298 DNA METHYLASE - MYCOBACTERIUM TUBERCULOSIS.
O34139 HSDM - KLEBSIELLA PNEUMONIAE.
O37396 DNA ADENINE METHYLTRANSFERASE - CHLORELLA VIRUS NY-2A (CV-NY2A).
O37397 DNA ADENINE METHYLTRANSFERASE - CHLORELLA VIRUS NY-2A (CV-NY2A).
O50667 HYPOTHETICAL 150.9 KD PROTEIN - BORRELIA BURGDORFERI (LYME DISEASE SPIROCHETE).
O50698 HYPOTHETICAL 151.0 KD PROTEIN - BORRELIA BURGDORFERI (LYME DISEASE SPIROCHETE).
O52273 MODIFICATION SUBUNIT - LACTOCOCCUS LACTIS BV. DIACETYLACTIS.
O54431 TYPE IC MODIFICATION SUBUNIT - LACTOCOCCUS LACTIS.
O68168 HSDM - LACTOCOCCUS LACTIS.
O82906 PLASMID PO157 DNA, COMPLETE SEQUENCE - ESCHERICHIA COLI.
O85299 HAEIV RESTRICTION/MODIFICATION SYSTEM - HAEMOPHILUS AEGYPTIUS.
O85862 PROBABLY METHYLASE/HELICASE - SPHINGOMONAS AROMATICIVORANS.
P71445 ABIM AND ABIR GENES - LACTOCOCCUS LACTIS.
P72289 METHYLASE - RHIZOBIUM LEGUMINOSARUM.
P72417 HSDM, HSDS & HSDR GENES - SALMONELLA TYPHIMURIUM.
P72418 STY SBLI - SALMONELLA TYPHIMURIUM.
P75436 TYPE I RESTRICTION ENZYME HSDM - MYCOPLASMA PNEUMONIAE.
P95510 ALXA AND HSDM - PASTEURELLA HAEMOLYTICA.
P95687 PUTATIVE START AND STOP CODONS - STAPHYLOCOCCUS AUREUS BACTERIOPHAGE PHI-42.
P95732 STYSKI METHYLASE - SALMONELLA TYPHIMURIUM.
P96188 XAMI DNA METHYLTRANSFERASE - XANTHOMONAS CAMPESTRIS.
P96868 HYPOTHETICAL 60.7 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
Q09050 TYPE I RESTRICTION ENZYME M PROTEIN (EC 2.1.1.72) - ESCHERICHIA COLI.
Q09051 TYPE I RESTRICTION ENZYME M PROTEIN (EC 2.1.1.72) - ESCHERICHIA COLI.
Q47163 (CTR5X) - ESCHERICHIA COLI.
Q47282 ECOE TYPE I RESTRICTION MODIFICATION ENZYME M SUBUNIT - ESCHERICHIA COLI.
Q53293 METHYLTRANSFERASE - ACINETOBACTER CALCOACETICUS.
Q53609 SALI MODIFICATION METHYLTRANSFERASE - STREPTOMYCES ALBUS.
Q56238 METHYLASE - THERMUS AQUATICUS (SUBSP. THERMOPHILUS).
Q56752 ACCI METHYLASE - BERGEYELLA ZOOHELCUM.
Q56788 XMNI METHYLTRANSFERASE - XANTHOMONAS MANIHOTIS.
Q57168 HYPOTHETICAL PROTEIN HI1287 - HAEMOPHILUS INFLUENZAE.
Q96717 DNA ADENINE METHYLTRANSFERASE - CHLORELLA VIRUS SC-1A.
Q96719 DNA ADENINE METHYLTRANSFERASE - CHLORELLA VIRUS SC-1A.
T1M1_ECOLI TYPE I RESTRICTION ENZYME ECOR124II M PROTEIN (EC 2.1.1.72) - ESCHERICHIA COLI.
T1M_ECOLI TYPE I RESTRICTION ENZYME ECOK I M PROTEIN (EC 2.1.1.72) - ESCHERICHIA COLI.
T1M_SALPO TYPE I RESTRICTION ENZYME STYSPI M PROTEIN (EC 2.1.1.72) - SALMONELLA POTSDAM.
T1M_SALTY TYPE I RESTRICTION ENZYME STYSJI M PROTEIN (EC 2.1.1.72) - SALMONELLA TYPHIMURIUM.
T257_ECOLI TYPE IIS RESTRICTION ENZYME ECO57I (EC 3.1.21.4) (ENDONUCLEASE ECO57I) [INCLUDES: ADENINE-SPECIFIC METHYLTRANSFERASE ACTIVITY (EC 2.1.1.72)] - ESCHERICHIA COLI.
T4BA_BACCO RESTRICTION ENZYME BGCI ALPHA SUBUNIT (EC 3.1.21.-) [INCLUDES: ADENINE-SPECIFIC METHYLTRANSFERASE ACTIVITY (EC 2.1.1.72)] - BACILLUS COAGULANS.
YY02_METJA HYPOTHETICAL PROTEIN MJECS02 - METHANOCOCCUS JANNASCHII.
YZ42_METJA HYPOTHETICAL PROTEIN MJECL42 - METHANOCOCCUS JANNASCHII.

MTM1_MICAM MODIFICATION METHYLASE MAMI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE MAMI) (M.MAMI) - MICROBACTERIUM AMMONIAPHILUM.
O25380 HYPOTHETICAL 107.4 KD PROTEIN - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25908 PUTATIVE ADENINE SPECIFIC DNA METHYLTRANSFERASE - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O30381 N6 ADENINE METHYLATION (M) SUBUNIT HOMOLOG (M) - MYCOPLASMA PULMONIS.
Q12463 CHROMOSOME XV READING FRAME ORF YOL124C - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Q50358 RESTRICTION-MODIFICATION ENZYME SUBUNIT M1 - MYCOPLASMA PULMONIS.
Y724_METTH HYPOTHETICAL PROTEIN MTH724 - METHANOBACTERIUM THERMOAUTOTROPHICUM.
YC20_METJA HYPOTHETICAL PROTEIN MJ1220 - METHANOCOCCUS JANNASCHII.

O24895 ADENINE/CYTOSINE DNA METHYLTRANSFERASE - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O28105 HYPOTHETICAL PROTEIN AF2178 - ARCHAEOGLOBUS FULGIDUS.
O52000 ORF H1130 - HALOBACTERIUM SP.
O52001 SIMILAR TO ECO57I - HALOBACTERIUM SP.
O52711 SAPI M1 METHYLTRANSFERASE - SACCHAROPOLYSPORA SP.
O53069 LLABII-METHYLASE - LACTOCOCCUS LACTIS (SUBSP. CREMORIS) (STREPTOCOCCUS CREMORIS).
O58378 364AA LONG HYPOTHETICAL PROTEIN - PYROCOCCUS HORIKOSHII.
O66904 HYPOTHETICAL 27.6 KD PROTEIN - AQUIFEX AEOLICUS.
P70986 BSOBI METHYLASE - BACILLUS STEAROTHERMOPHILUS.
P95799 RESTRICTION METHYLASE - SERRATIA MARCESCENS.
Q52611 R-FACTOR RTS1 RESTRICTION ENDONUCLEASE PVURTS1 I - PROTEUS VULGARIS.
Q58606 HYPOTHETICAL PROTEIN MJ1209 - METHANOCOCCUS JANNASCHII.
Y438_METJA HYPOTHETICAL PROTEIN MJ0438 - METHANOCOCCUS JANNASCHII.
Y710_METJA HYPOTHETICAL PROTEIN MJ0710 - METHANOCOCCUS JANNASCHII.
YJJT_ECOLI HYPOTHETICAL 37.6 KD PROTEIN IN FHUF-HOLD INTERGENIC REGION (F343B) - ESCHERICHIA COLI.
YPSC_BACSU HYPOTHETICAL 43.5 KD PROTEIN IN COTD-KDUD INTERGENIC REGION PRECURSOR - BACILLUS SUBTILIS.
YTXK_BACSU HYPOTHETICAL 37.4 KD PROTEIN IN ACKA-SSPA INTERGENIC REGION - BACILLUS SUBTILIS.
Scan History
OWL28_0    4  100  NSINGLE    
SPTR37_9f 3 190 NSINGLE
Initial Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
GVFYTPKEIAADFFDYL MTV1_VIBS3 118 118 -
GQFFTPSSISIFMACLF MTBB_BACSU 26 26 -
FQFFQTNFNQLQLKKLI D64220 51 51 -
GQFMSSSAVSELMANLF MTPS_PROST 36 36 -
GEFFTPQHVSKLIAQLA T1M1_ECOLI 197 197 -
GRVETPPEVVDFMVSLA MTTA_THEAQ 19 19 -
GRVETPPGLVRFMVGLA MTT8_THETH 17 17 -
GQFFTPTHIVKYMIGLM MTHC_HAEIN 10 10 -
GAVYTKPIIVDLILDLT MTV1_BACST 11 11 -
AQFFTPFPIAYAMAKWI MTA1_ACICA 30 30 -
GAHYTPTDLGDIIAKRL MTB3_BACAR 16 16 -
GQYFTPRPLIKTIIHLL T1M_ECOLI 147 147 -
GGYYTPQNLADYVTKWV MT57_ECOLI 14 14 -
DVVTTPTHIVKEIIRNT T257_ECOLI 354 354 -
GAIFTRSEMVDFILDLA MTP7_PSEAE 11 11 -

Motif 2 width=15
Element Seqn Id St Int Rpt
VLEPAFGLGVFSRAI MTA1_ACICA 55 8 -
TKTKLKGNGDFSSDE D64220 88 20 -
IYDPAAGSGSLLLQA T1M1_ECOLI 223 9 -
VLEPACAHGPFLRAF MTTA_THEAQ 43 7 -
VLEPACADGPFLRAF MTT8_THETH 41 7 -
ILEPSSGNGVFLDSL MTHC_HAEIN 34 7 -
LLDPSFGDGVFLEAA MTV1_BACST 40 12 -
GLDPSCGDGELLLSL MTB3_BACAR 49 16 -
VQDPAAGTAGFLIEA T1M_ECOLI 171 7 -
ILEPSCGDGVFIQAI MT57_ECOLI 38 7 -
FADIACGSGAFIIVA T257_ECOLI 388 17 -
LLEPSFGGGDFLLPI MTP7_PSEAE 40 12 -
FCDPCCGTGNFLIEA MTV1_VIBS3 143 8 -
VLDAGAGIGSLTSAF MTBB_BACSU 52 9 -
ILDAGAGVGSLTAAF MTPS_PROST 61 8 -

Motif 3 width=13
Element Seqn Id St Int Rpt
YNKAILNPPYLKI MTPS_PROST 146 70 -
FDAIVSNPPYSVK T1M1_ECOLI 296 58 -
FDLILGNPPYGIV MTTA_THEAQ 99 41 -
FDLILGNPPYGIV MTT8_THETH 97 41 -
YDSIIGNPPYVRW MTHC_HAEIN 85 36 -
FDFVVGNPPYVRQ MTV1_BACST 137 82 -
YDGIICNPPYFKF MTA1_ACICA 117 47 -
VDLIIANPPYVRT MTB3_BACAR 132 68 -
ADIVVTNPPFSLF D64220 110 7 -
AHIVATNPPFGSA T1M_ECOLI 260 74 -
FDGALGNPPFIRY MT57_ECOLI 110 57 -
FDVIVGNPPYMAT T257_ECOLI 520 117 -
FDFVVGNPPYVRP MTP7_PSEAE 132 77 -
YDVIFTNPPWGKK MTV1_VIBS3 211 53 -
FTHAILNPPYKKI MTBB_BACSU 137 70 -

Motif 4 width=25
Element Seqn Id St Int Rpt
DTSAIFFFASMKILNSSGYLGFLLQ MTV1_VIBS3 243 19 -
NLYSAFVALAIKQLKSGGELVAITP MTPS_PROST 177 18 -
KADFAFVLHALNYLSAKGRAAIVCF T1M1_ECOLI 334 25 -
VSYNHIFTYFKTNKLWFGYTVNKTM D64220 145 22 -
NLYGAFLEKAVRLLKPGGVLVFVVP MTTA_THEAQ 141 29 -
NLYGAFIEKSVRLLREGGTLVFVVP MTT8_THETH 139 29 -
DYFYIFIIKSILQLKVGGELIFICP MTHC_HAEIN 123 25 -
DLYVPFIQHSLELLSEQGTLGIICS MTV1_BACST 172 22 -
NLYTLFLLKSIHQLSQNGRCAYIIP MTA1_ACICA 154 24 -
DLYHAFLVAMTLQLKPGGLIGVITS MTB3_BACAR 166 21 -
NKQLCFMQHIIETLHPGGRAAVVVP T1M_ECOLI 287 14 -
NAWVPFLLSSLALLKQGGRIGMVIP MT57_ECOLI 149 26 -
DKYFLFIERSIQILKEYGYLGYILP T257_ECOLI 558 25 -
DIYIPFIERSLTALSAGGNLGFICA MTP7_PSEAE 167 22 -
NLYSAFVALTVDLMSDGGEIVFIIP MTBB_BACSU 168 18 -
Final Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
GEFFTPQHVSKLIAQLA Q47163 197 197 -
GEFFTPQHVSKLIAQLA T1M1_ECOLI 197 197 -
GQFYTPSEVSLLSSLLL O25953 158 158 -
GQVFTPKKIVDFMLTLK O25568 10 10 -
GAYYTPDEITSYIAKNT YY02_METJA 440 440 -
GEFYTPRAVTRFMVDRV P95732 166 166 -
GEFYTPRAVTRFMVNRI Q47282 162 162 -
GEFYTPRAVTRFMVDRV Q09051 162 162 -
GRVETPPEVVDFMVSLA MTTA_THEAQ 19 19 -
GRVETPPGLVRFMVGLA MTT8_THETH 17 17 -
GRVETPPGLVRFMVGLA Q56238 17 17 -
GIFLTPDEVVREVVSFV Q56788 121 121 -
GQFFTPTHIVKYMIGLM MTHC_HAEIN 10 10 -
GQFFTPTHIVKYMIGLM MTHD_HAEIN 10 10 -
GEFYTPQAVSRIMSEIT O52273 192 192 -
GEFFTPQEVSELLAKIT O25521 205 205 -
GIVYTPSLVSDFIVEET P71445 94 94 -
GAFYTPPALTARLMELA P72289 129 129 -
GEFYTPQAVSKIMSEIT O54431 192 192 -
GQYFTPRPLIKTIIHLL T1M_SALPO 147 147 -
GSFYTPSFITSYMCKES O26046 438 438 -
GIFFTPKPLRDIVFQHI Q96717 23 23 -
GAVYTKPIIVDLILDLT MTV1_BACST 11 11 -
GKFYTPRSLTKLIVDVL YZ42_METJA 226 226 -
GQYFTPKSIVTLIVEML P95510 288 288 -
GAHFTPDKLAEVIAKRI MTB1_BACST 17 17 -
GIVLTPRHITSLMAELI T4BA_BACCO 325 325 -
AQFFTPFPIAYAMAKWI Q56752 30 30 -
AQFFTPFPIAYAMAKWI Q53293 30 30 -
AQFFTPFPIAYAMAKWI MTA1_ACICA 30 30 -
QKHYTPHGIVTFMGNII P72417 131 131 -
GQYYTPKEISEVMARIL O68168 188 188 -
GVFFTPKDIRDIIFEEL O37397 24 24 -
GAHYTPTDLGDIIAKRL MTB3_BACAR 16 16 -
GIYFTPKSVRDLVWDYI Q96719 22 22 -
GVFFTPKDIRDIVFEEL MTR1_CHVN6 24 24 -
GQYFTPRPLIKTIIHLL T1M_SALTY 147 147 -
GQYFTPRPLIKTIIHLL T1M_ECOLI 147 147 -
GQYFTPRPLIKTIIHLL Q09050 147 147 -
GIFFTPKTVREKLFGFT MTC3_CHVN1 26 26 -
GIFFTPKSVREKLFGYV O37396 23 23 -
GGYYTPQNLADYVTKWV MT57_ECOLI 14 14 -
GEFFTPQDISELLARIA P75436 207 207 -
GQYFTPKSIVSLIVEML Q57168 116 116 -
GEFYTPKCVVTLLTEML O34139 185 185 -
GEFYTPKCVVTLLTEML P72418 185 185 -
GAYYTPDDLTDFMVISS O50667 479 479 -
GAYYTPDDLTDFMVISS O50698 473 473 -
GQFFTPMPIVKFLISSL O85299 424 424 -
AEYYTPLSIASIIAKLL O25210 207 207 -
DVVTTPTHIVKEIIRNT T257_ECOLI 354 354 -
GEFFTPPSVVKVIVEVL O33298 201 201 -
GGYYTPPAVARFLAHWV P96868 41 41 -
GAIFTRSEMVDFILDLA MTP7_PSEAE 11 11 -
GIYYTPNRIVEQLFTLP O25223 111 111 -
GIVLTPRHITNLMCELI P95687 330 330 -
GVFYTPKEIAADFFDYL MTV1_VIBS3 118 118 -
GQFFTPSSISIFMACLF MTBB_BACSU 26 26 -
GEVYTPREVIRLLVEIL O27025 285 285 -
GAVYTPAPIVRSMMTWL P96188 74 74 -
GQFATPPSLAGEIMRYT Q53609 32 32 -
QQFSTPPALACLAVHLA O85862 120 120 -
QLFVTPAPVCDRLVTLA O82906 30 30 -
GQFMSSSAVSELMANLF MTPS_PROST 36 36 -

Motif 2 width=15
Element Seqn Id St Int Rpt
IYDPAAGSGSLLLQA Q47163 223 9 -
IYDPAAGSGSLLLQA T1M1_ECOLI 223 9 -
IYDPACGSGSLLLKA O25953 186 11 -
VLEPSAGDGSFLKRL O25568 32 5 -
ILDPAVGSGHFLISA YY02_METJA 511 54 -
IMDPACGTGGFLACA P95732 190 7 -
IMDPACGTGGFLACA Q47282 186 7 -
IMDPACGTGGFLACA Q09051 186 7 -
VLEPACAHGPFLRAF MTTA_THEAQ 43 7 -
VLEPACADGPFLRAF MTT8_THETH 41 7 -
VLEPACADGPFLRAF Q56238 41 7 -
CLDPACGSGTFLIEV Q56788 145 7 -
ILEPSSGNGVFLDSL MTHC_HAEIN 34 7 -
ILEPSSGNGVFLDSL MTHD_HAEIN 34 7 -
IYDPAMGSGSLMLNI O52273 220 11 -
VYDPCCGSGSLLLQF O25521 231 9 -
IGDFSCGCGEFLLSA P71445 120 9 -
VLDPACGGGAFLLPV P72289 157 11 -
IYDPAMGSGSLMLNI O54431 220 11 -
VQDPAAGTAGFLIEA T1M_SALPO 171 7 -
ICDPAVGSGHFLVSA O26046 502 47 -
VLEPSCGSGEFLVEC Q96717 46 6 -
LLDPSFGDGVFLEAA MTV1_BACST 40 12 -
IFDPACGSGGFFVSA YZ42_METJA 249 6 -
IYDPAMGSGGFFVQA P95510 311 6 -
VLDPACGDGELLLAI MTB1_BACST 47 13 -
VLDPACGTGAFLISA T4BA_BACCO 349 7 -
VLEPAFGLGVFSRAI Q56752 55 8 -
VLEPAFGLGVFSRAI Q53293 55 8 -
VLEPAFGLGVFSRAI MTA1_ACICA 55 8 -
FFDPACGSGEFISEI P72417 155 7 -
IYDPAVGSASLLITT O68168 216 11 -
ILEPTCGTGEFIDDC O37397 51 10 -
GLDPSCGDGELLLSL MTB3_BACAR 49 16 -
ILEPSAGSGEFFDDC Q96719 45 6 -
ILEPTCGTGEFISDC MTR1_CHVN6 48 7 -
VQDPAAGTAGFLIEA T1M_SALTY 171 7 -
VQDPAAGTAGFLIEA T1M_ECOLI 171 7 -
VQDPAAGTAGFLIEA Q09050 171 7 -
ILEPSCGTGEIISEC MTC3_CHVN1 53 10 -
ILEPSCGTGEIISDC O37396 45 5 -
ILEPSCGDGVFIQAI MT57_ECOLI 38 7 -
VYDMACGSGSLLLQV P75436 233 9 -
VYDPAMGSGGFFVQT Q57168 139 6 -
IYDPCCGSAGMFVQS O34139 208 6 -
IYDPCCGSAGMFVQS P72418 208 6 -
IIDNSCGSGHFLISC O50667 510 14 -
IIDNSCGSGHFLISC O50698 504 14 -
VIDYACGAGHFLTEY O85299 454 13 -
IYDPSAGTGTLLMAL O25210 233 9 -
FADIACGSGAFIIVA T257_ECOLI 388 17 -
VYDPCCGSGGMFVQT O33298 224 6 -
ILEPSCGDGRILREL P96868 64 6 -
LLEPSFGGGDFLLPI MTP7_PSEAE 40 12 -
FCDPAVGSGNFIMHA O25223 137 9 -
VLDPCCGSGGFLIAA P95687 354 7 -
FCDPCCGTGNFLIEA MTV1_VIBS3 143 8 -
VLDAGAGIGSLTSAF MTBB_BACSU 52 9 -
VYDPASASNGMLIIS O27025 309 7 -
IVDPGAGSGRFILAA P96188 99 8 -
FLEPSCGSGSFFSAL Q53609 59 10 -
FLEPSAGTGIIAALA O85862 144 7 -
ILEPSAGTGAILRAI O82906 54 7 -
ILDAGAGVGSLTAAF MTPS_PROST 61 8 -

Motif 3 width=13
Element Seqn Id St Int Rpt
FDAIVSNPPYSVK Q47163 296 58 -
FDAIVSNPPYSVK T1M1_ECOLI 296 58 -
FDYVVANPPFSLK O25953 261 60 -
FDTIIGNPPYVKH O25568 77 30 -
FDVIIGNPPYGNL YY02_METJA 758 232 -
LDVIVTNPPFGGT P95732 271 66 -
VDVIVTNPPFGGT Q47282 267 66 -
LDVIVTNPPFGGT Q09051 267 66 -
FDLILGNPPYGIV MTTA_THEAQ 99 41 -
FDLILGNPPYGIV MTT8_THETH 97 41 -
FDLILGNPPYGIV Q56238 97 41 -
FDFILTNPPFGVT Q56788 223 63 -
YDSIIGNPPYVRW MTHC_HAEIN 85 36 -
YDSIIGNPPYVRW MTHD_HAEIN 85 36 -
FDSVVMNPPYSAK O52273 293 58 -
FDAIVSNPPYSTK O25521 304 58 -
IDFIIGNPPYVKI P71445 148 13 -
FDLVIGNPPYGRV P72289 246 74 -
FDSVCMNPPYSAK O54431 293 58 -
ADIVATNPPFGSA T1M_SALPO 260 74 -
FDCIIGNPPYIRQ O26046 843 326 -
FDLIIGNPPFVQM Q96717 104 43 -
FDFVVGNPPYVRQ MTV1_BACST 137 82 -
FDYVVANPPFNDS YZ42_METJA 321 57 -
MDVVMANPPFNQK P95510 385 59 -
VDIIIANPPYVRT MTB1_BACST 127 65 -
INKILMNPPYSQA T4BA_BACCO 430 66 -
YDGIICNPPYFKF Q56752 117 47 -
YDGIICNPPYFKF Q53293 117 47 -
YDGIICNPPYFKF MTA1_ACICA 117 47 -
FDIILSNPPFSLK P72417 218 48 -
FDAVMANPPYSAH O68168 298 67 -
FDLIIGNPPFFTR O37397 109 43 -
VDLIIANPPYVRT MTB3_BACAR 132 68 -
FDLIIGNPPFVQR Q96719 97 37 -
FDLIIGNPPYFTR MTR1_CHVN6 106 43 -
AHIVATNPPFGSA T1M_SALTY 260 74 -
AHIVATNPPFGSA T1M_ECOLI 260 74 -
AHIVATNPPFGSA Q09050 260 74 -
FDFIVGNPPYVVR MTC3_CHVN1 113 45 -
FDFIVGNPPFVVR O37396 105 45 -
FDGALGNPPFIRY MT57_ECOLI 110 57 -
FEVVVSNPPYSIS P75436 314 66 -
MDFIMANPHFNDK Q57168 213 59 -
ADYILANPPFNLK O34139 282 59 -
ADYILANPPFNLK P72418 282 59 -
FDIVIGNPPWEKT O50667 767 242 -
FDIVIGNPPWEKT O50698 761 242 -
FSLLVANPPYSVK O85299 538 69 -
MDYIVSNPPFKLD O25210 306 58 -
FDVIVGNPPYMAT T257_ECOLI 520 117 -
MDYVMANLPFNIK O33298 299 60 -
WDGVAGNPPYIRF P96868 121 42 -
FDFVVGNPPYVRP MTP7_PSEAE 132 77 -
FDCIFTNPPWGKK O25223 203 51 -
ITKALINPPYSQA P95687 434 65 -
YDVIFTNPPWGKK MTV1_VIBS3 211 53 -
FTHAILNPPYKKI MTBB_BACSU 137 70 -
FDVVIANPPWNQD O27025 386 62 -
ITAFIGNPPYVRH P96188 166 52 -
ASLLVANPPYVRH Q53609 125 51 -
PSVIVMNPPFSVS O85862 205 46 -
YSRVIINPPFSHG O82906 113 44 -
YNKAILNPPYLKI MTPS_PROST 146 70 -

Motif 4 width=25
Element Seqn Id St Int Rpt
KADFAFVLHALNYLSAKGRAAIVCF Q47163 334 25 -
KADFAFVLHALNYLSAKGRAAIVCF T1M1_ECOLI 334 25 -
NGDFAFLLHIIKSLKNTGKGAVILP O25953 305 31 -
NLYLFFIEKAIKHLKPKGELIFITP O25568 110 20 -
DIFVTFIVHSSKLLKNEGYLGFIIP YY02_METJA 788 17 -
ETADLFLQLIIEVLAKNGRAAVVLP P95732 300 16 -
ETADLFLQLIIEVLADKGRAAVVLP Q47282 296 16 -
ETADLFLQLIVEVLAKNGRAAVVLP Q09051 296 16 -
NLYGAFLEKAVRLLKPGGVLVFVVP MTTA_THEAQ 141 29 -
NLYGAFIEKSVRLLREGGTLVFVVP MTT8_THETH 139 29 -
NLYGAFIEKSVRLLREGGTLVFVVP Q56238 139 29 -
SSEWLFVEQSLRWLKPGGTLAVVLP Q56788 261 25 -
DYFYIFIIKSILQLKVGGELIFICP MTHC_HAEIN 123 25 -
DYFYIFIIKSILQLKVGGELIFICP MTHD_HAEIN 123 25 -
KADFAFLLHGFYHLKESGTMGIVLP O52273 329 23 -
AADLAFTMHMLSYLSNSGTAAIVEF O25521 342 25 -
NLFYAFIELSLNILSENGKIGYIVP P71445 184 23 -
NMYGLFTDLALQWARKGGVVAYVTP P72289 277 18 -
KADFAFLLHGFYHLKESGTMGIVLP O54431 329 23 -
NKQLCFMQHIIETLPPGGRAAAVVP T1M_SALPO 287 14 -
DIYTYFFALAFHLLKEKGFSAFITS O26046 878 22 -
LYIEILFKCMTQHLNDNGVLAMVIP Q96717 130 13 -
DLYVPFIQHSLELLSEQGTLGIICS MTV1_BACST 172 22 -
NANYMWILHFIYHTAPNGKAGFVMA YZ42_METJA 361 27 -
NANFAWLQHMIYHLSPKGKMALLPR P95510 419 21 -
DLYQAFLVAMTQQLKSNGIIGVITS MTB1_BACST 161 21 -
LSELSFIQQALEMLVVGGKLCAIVP T4BA_BACCO 450 7 -
NLYTLFLLKSIHQLSQNGRCAYIIP Q56752 154 24 -
NLYTLFLLKSIHQLSQNGRCAYIIP Q53293 154 24 -
NLYTLFLLKSIHQLSQNGRCAYIIP MTA1_ACICA 154 24 -
NADFAFLQYCIFMLKDNGRAAIILP P72417 249 18 -
KADYSFLLHCLYHTKESGRVAIILP O68168 332 21 -
ICIEVVHKCMTGHLAENGILAMVLP O37397 138 16 -
DLYHAFLVAMTLQLKPGGLIGVITS MTB3_BACAR 166 21 -
LYVEFIYKCLTQHLAPGGTLAFVIP Q96719 126 16 -
ICIEVLHKCITRHLADNGMLAMVLP MTR1_CHVN6 135 16 -
NKQLCFMQHIIETLHPGGRAAVVVP T1M_SALTY 287 14 -
NKQLCFMQHIIETLHPGGRAAVVVP T1M_ECOLI 287 14 -
NKQLCFMQHIIETLHPGGRAAVVVP Q09050 287 14 -
LYVEFLYKCITEHLKEDGILAFIIP MTC3_CHVN1 142 16 -
LYVEFLFKCITEHLKEDGILAFIIP O37396 134 16 -
NAWVPFLLSSLALLKQGGRIGMVIP MT57_ECOLI 149 26 -
KADLAFVLHALYVLGQEGTAAIVCF P75436 352 25 -
NANFAWLQHMIYHLSPNGKIALLLA Q57168 247 21 -
NANYGWILHMLSKLSANGTAGFVLA O34139 318 23 -
NANYGWILHMLSKLSANGTAGFVLA P72418 318 23 -
NLFRYFVAFNLKLIKENGNLTYLVP O50667 849 69 -
NLFRYFVTFNLKLIKEKGNLTYLVP O50698 843 69 -
SIETFFIEKAKQLLHAEGIAVIVLP O85299 578 27 -
PIYTLFFQHCLNMLSNKGKGAIIVP O25210 349 30 -
DKYFLFIERSIQILKEYGYLGYILP T257_ECOLI 558 25 -
NANYAWIQHILYKLAPGGRAGVVMA O33298 331 19 -
NAWVPFVVASTTLARDGGRVGLVVP P96868 160 26 -
DIYIPFIERSLTALSAGGNLGFICA MTP7_PSEAE 167 22 -
DSASLFFIASLNCLKENAHLGLLLP O25223 235 19 -
LSEISFINETLSLMKIGAKLAAIVP P95687 454 7 -
DTSAIFFFASMKILNSSGYLGFLLQ MTV1_VIBS3 243 19 -
NLYSAFVALTVDLMSDGGEIVFIIP MTBB_BACSU 168 18 -
SADWAWIQHMIASAKDDGRIGVVID O27025 424 25 -
GLHLHFFLQTRLLAKAGDVGAFITS P96188 205 26 -
GLYLYFVLLSHRLLRADAVSTWLIP Q53609 165 27 -
NTAARHLRAALDHLLPGGRVVAIMP O85862 225 7 -
GQDIRHILRAFSLLRPGGVLVAVCL O82906 125 -1 -
NLYSAFVALAIKQLKSGGELVAITP MTPS_PROST 177 18 -