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PR00506

Identifier
D21N6MTFRASE  [View Relations]  [View Alignment]  
Accession
PR00506
No. of Motifs
4
Creation Date
24-MAY-1995  (UPDATE 14-JUN-1999)
Title
D21 class N6 adenine-specific DNA methyltransferase signature
Database References

PROSITE; PS00092 N6_MTASE
BLOCKS; BL00092
INTERPRO; IPR002295
PDB; 1ADM
SCOP; 1ADM
Literature References
1. CHENG, X.
Structure and function of DNA methyltransferases.
ANNU.REV.BIOPHYS.BIOMOL.STRUCT. 24 293-318 (1995).
 
2. LABAHN, J., GRANZIN, J., SCHLUCKEBIER, G., ROBINSON, D.P., JACK, W.E.,
SCHILDKRAUT, I. AND SAENGER, W.
Three-dimensional structure of the adenine-specific DNA methyltransferase
M.TaqI in complex with the cofactor S-adenosylmethionine.
PROC.NATL.ACAD.SCI.U.S.A. 91 10957-10961 (1994).
 
3. TIMINSKAS, A., BUTKUS, V. AND JANULAITIS, A.
Sequence motifs characteristic for DNA [cytosine-N4] and DNA [adenine-N6]
methyltransferases. Classification of all DNA methyltransferases.
GENE 157 3-11 (1995).
 
4. WILLCOCK, D.F., DRYDEN, D.T. AND MURRAY, N.E.
A mutational analysis of the two motifs common to adenine
methyltransferases.
EMBO J. 13 3902-3908 (1994).

Documentation
In prokaryotes, the major role of DNA methylation is to protect host
DNA against degradation by restriction enzymes. There are 2 major classes
of DNA methyltransferase that differ in the nature of the modifications 
they effect [1]. The members of one class (C-MTases) methylate a ring
carbon and form C5-methylcytosine (see PRINTS signature C5METTRFRASE).
Members of the second class (N-MTases) methylate exocyclic nitrogens and
form either N4-methylcytosine (N4-MTases) or N6-methyladenine (N6-MTases).
Both classes of MTase utilise the cofactor S-adenosyl-L-methionine (SAM)
as the methyl donor and are active as monomeric enzymes [1].
 
The structure of N6-MTase TaqI (M.TaqI) has been resolved to 2.4A [2].
The molecule folds into 2 domains: an N-terminal catalytic domain, which
contains the catalytic and cofactor binding sites, and comprises a central
9-stranded beta-sheet, surrounded by 5 helices; and a C-terminal DNA
recognition domain, which is formed by 4 small beta-sheets and 8 alpha-
helices. The N- and C-terminal domains form a cleft that accommodates the
DNA substrate.
 
A classification of N-MTases has been proposed, based on conserved motif
(CM) arrangements [3]. According to this classification, N6-MTases that
have a DPPY motif (CM II) occuring before the FxGxG motif (CM I) are
designated D21 class N6-adenine MTases.
 
D21N6MTFRASE is a 4-element fingerprint that provides a signature for the
D21 class N6-adenine MTases. The fingerprint was derived from an initial
alignment of 13 sequences. The motifs were drawn from the conserved
regions used by Timinskas et al. [3] in their DNA MTase classification:
the motifs correspond to CM II, III, Is and I, respectively - motif 1,
which contains the N-MTase-specific tetrapeptide DPPY (cf. PROSITE pattern
N6_MTASE), is important for methylation; and motif 4, which contains the
FxGxG pattern, forms part of the cofactor (SAM) binding site [4]. Three
iterations on OWL27.1 were required to reach convergence, at which point a 
true set comprising 22 sequences was identified. Several partial matches
were also found: S53866 is a phage HP1 cytosine MTase (M.PhiHII) that fails
to match motif 3; MTC9_CITFR (M.Cfr9I), MTC1_CITFR (M.CfrBI) and MTX1_XANCC
(XcyI) fail to match motif 1 and belong to the S21 class N4-cytosine MTases;
MTB2_BACAM (M.BamHII) and MTP2_PROVU (M.PvuII), which match motifs 3 and 4,
and MTSM_SERMA (M.SmaI), which match motifs 2 and 4, also belong to the S21
class N4-cytosine MTases; MTB3_BACAR, BAMBAN111 (M.BanIII), MTB1_BACST
(M.BseCI), MTTA_THEAQ and TATAQI (M.TaqI), which match motifs 1 and 2, are
N12 class N6-adenine MTases, with CM I occuring before the CM II. 
 
An update on SPTR37_9f identified a true set of 54 sequences, and 12
partial matches.
Summary Information
  54 codes involving  4 elements
5 codes involving 3 elements
7 codes involving 2 elements
Composite Feature Index
454545454
35145
24334
1234
True Positives
ML22_LACLC    MT1C_MORBO    MT22_STRPN    MT42_METJA    
MTB1_BACAM MTB2_BACAM MTC1_CITFR MTC9_CITFR
MTEC_ENTCL MTH1_HAEIN MTH1_HAEPA MTH2_HAEHA
MTH3_HAEIN MTHZ_METTF MTK1_KLEPN MTM1_METJA
MTM2_MORBO MTP2_PROVU MTR1_RHOSH MTSM_SERMA
MTX1_XANCC O03956 O24918 O25040
O25315 O25907 O25920 O25921
O28863 O30569 O30570 O51937
O52513 O68556 O68565 O68568
O68789 O74053 O74074 O82897
O86267 P71366 P94454 P96424
Q08802 Q38206 Q45489 Q45971
Q46975 Q56638 T3MO_BPP1 T3MO_ECOLI
T3MO_SALTY YHDJ_ECOLI
True Positive Partials
Codes involving 3 elements
MTMW_METWO O24891 O25043 O52692
O58333
Codes involving 2 elements
MTTA_THEAQ O25922 O32491 O64360
P70724 P70802 Q58606
Sequence Titles
ML22_LACLC  MODIFICATION METHYLASE LLADCHI B (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE LLADCHI B) (M.LLADCHI B) (LLAII) - LACTOCOCCUS LACTIS (SUBSP. CREMORIS) (STREPTOCOCCUS CREMORIS). 
MT1C_MORBO MODIFICATION METHYLASE MBOI C (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE MBOI C) (M.MBOI C) - MORAXELLA BOVIS.
MT22_STRPN MODIFICATION METHYLASE DPNII 2 (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 2) (M.DPNII 2) - STREPTOCOCCUS PNEUMONIAE.
MT42_METJA PROBABLE MODIFICATION METHYLASE MJ1498 (EC 2.1.1.113) (N-4 CYTOSINE- SPECIFIC METHYLTRANSFERASE MJ1498) - METHANOCOCCUS JANNASCHII.
MTB1_BACAM MODIFICATION METHYLASE BAMHI (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE BAMHI) (M.BAMHI) - BACILLUS AMYLOLIQUEFACIENS.
MTB2_BACAM MODIFICATION METHYLASE BAMHII (EC 2.1.1.113) (N-4 CYTOSINE- SPECIFIC METHYLTRANSFERASE BAMHII) (M.BAMHII) - BACILLUS AMYLOLIQUEFACIENS.
MTC1_CITFR MODIFICATION METHYLASE CFRBI (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE CFRBI) (M.CFRBI) - CITROBACTER FREUNDII.
MTC9_CITFR MODIFICATION METHYLASE CFR9I (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE CFR9I) (M.CFR9I) - CITROBACTER FREUNDII.
MTEC_ENTCL MODIFICATION METHYLASE ECAI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE ECAI) (M.ECAI) - ENTEROBACTER CLOACAE.
MTH1_HAEIN MODIFICATION METHYLASE HINFI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE HINFI) (M.HINFI) - HAEMOPHILUS INFLUENZAE.
MTH1_HAEPA MODIFICATION METHYLASE HPAI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE HPAI) (M.HPAI) - HAEMOPHILUS PARAINFLUENZAE.
MTH2_HAEHA MODIFICATION METHYLASE HHAII (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE HHAII) (M.HHAII) - HAEMOPHILUS HAEMOLYTICUS.
MTH3_HAEIN MODIFICATION METHYLASE HINDIII (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE HINDIII) (M.HINDIII) - HAEMOPHILUS INFLUENZAE.
MTHZ_METTF MODIFICATION METHYLASE MTHZI (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE MTHZI) (M.MTHZI) - METHANOBACTERIUM THERMOFORMICICUM.
MTK1_KLEPN MODIFICATION METHYLASE KPNI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE KPNI) (M.KPNI) - KLEBSIELLA PNEUMONIAE.
MTM1_METJA MODIFICATION METHYLASE MJAI (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE MJAI) (M.MJAI) - METHANOCOCCUS JANNASCHII.
MTM2_MORBO MODIFICATION METHYLASE MBOII (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE MBOII) (M.MBOII) - MORAXELLA BOVIS.
MTP2_PROVU MODIFICATION METHYLASE PVU II (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE PVU II) (M.PVUII) - PROTEUS VULGARIS.
MTR1_RHOSH MODIFICATION METHYLASE RSRI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE RSRI) (M.RSRI) - RHODOBACTER SPHAEROIDES (RHODOPSEUDOMONAS SPHAEROIDES).
MTSM_SERMA MODIFICATION METHYLASE SMAI (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE SMAI) (M.SMAI) - SERRATIA MARCESCENS.
MTX1_XANCC MODIFICATION METHYLASE XCYI (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE XCYI) (M.XYCI) - XANTHOMONAS CAMPESTRIS (PV. CYANOPSIDIS).
O03956 DNA ADENINE METHYLTRANSFERASE - BACTERIOPHAGE MX8.
O24918 TYPE II RESTRICTION ENZYME M PROTEIN (HSDM) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25040 ADENINE SPECIFIC DNA METHYLTRANSFERASE (MOD) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25315 ADENINE SPECIFIC DNA METHYLTRANSFERASE (MOD) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25907 ADENINE SPECIFIC DNA METHYLTRANSFERASE (HINFIM) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25920 TYPE IIS RESTRICTION ENZYME M1 PROTEIN (MOD) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25921 TYPE IIS RESTRICTION ENZYME M2 PROTEIN (MOD) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O28863 MODIFICATION METHYLASE, TYPE III R/M SYSTEM - ARCHAEOGLOBUS FULGIDUS.
O30569 ADENINE DNA METHYLTRANSFERASE - SINORHIZOBIUM MELILOTI.
O30570 ADENINE DNA METHYLTRANSFERASE - BRUCELLA ABORTUS.
O51937 TSP45I METHYLTRANSFERASE - THERMUS SP.
O52513 SFII METHYLTRANSFERASE - STREPTOMYCES FIMBRIATUS.
O68556 BGLI MODIFICATION METHYLTRANSFERASE - BACILLUS SUBTILIS.
O68565 DNA MODIFICATION METHYLTRANSFERASE M.XMAI - XANTHOMONAS CAMPESTRIS.
O68568 DNA MODIFICATION METHYLTRANSFERASE M.XBAI - XANTHOMONAS CAMPESTRIS.
O68789 ADENINE DNA METHYLTRANSFERASE HOMOLOG - YERSINIA PESTIS.
O74053 SITE-SPECIFIC DNA METHYLTRANSFERASE - CENARCHAEUM SYMBIOSUM.
O74074 SITE-SPECIFIC DNA METHYLTRANSFERASE - CENARCHAEUM SYMBIOSUM.
O82897 HEMAGGLUTININ-ASSOCIATED PROTEIN - ESCHERICHIA COLI.
O86267 METHYLASE - LACTOCOCCUS LACTIS.
P71366 TYPE III RESTRICTION-MODIFICATION ECOP15 ENZYME (MOD) - HAEMOPHILUS INFLUENZAE.
P94454 MODIFICATION METHYLASE F5I1 (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE F5I1) (M.F5I1) - BACILLUS STEAROTHERMOPHILUS.
P96424 METHYLASE M.PAC25I - PSEUDOMONAS ALCALIGENES.
Q08802 HYPOTHETICAL 25.6 KD PROTEIN IN VLP 3'REGION - VIBRIO CHOLERAE.
Q38206 CYTOSINE METHYLASE - BACTERIOPHAGE HP1.
Q45489 BGLII MODIFICATION METHYLASE - BACILLUS SUBTILIS.
Q45971 ADENINE METHYLTRANSFERASE - CAULOBACTER CRESCENTUS.
Q46975 ECOVIII MODIFICATION METHYLASE - ESCHERICHIA COLI.
Q56638 HAEMAGGLUTININ ASSOCIATED PROTEIN - VIBRIO CHOLERAE.
T3MO_BPP1 TYPE III RESTRICTION-MODIFICATION SYSTEM ECOPI ENZYME MOD (EC 2.1.1.72) (ECOPI METHYLTRANSFERASE) - BACTERIOPHAGE P1.
T3MO_ECOLI TYPE III RESTRICTION-MODIFICATION SYSTEM ECOP15I ENZYME MOD (EC 2.1.1.72) (ECOP15I METHYLTRANSFERASE) - ESCHERICHIA COLI.
T3MO_SALTY TYPE III RESTRICTION-MODIFICATION SYSTEM STYLTI ENZYME MOD (EC 2.1.1.72) (STYLTI METHYLTRANSFERASE) - SALMONELLA TYPHIMURIUM.
YHDJ_ECOLI HYPOTHETICAL ADENINE-SPECIFIC METHYLASE IN FIS-ENVR INTERGENIC REGION (EC 2.1.1.72) (ORF2) - ESCHERICHIA COLI.

MTMW_METWO MODIFICATION METHYLASE MWOI (EC 2.1.1.113) (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE MWOI) (M.MWOI) - METHANOBACTERIUM WOLFEI.
O24891 ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O25043 ADENINE SPECIFIC DNA METHYLTRANSFERASE (HPAIM) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O52692 SCAI METHYLTRANSFERASE - STREPTOMYCES CAESPITOSUS.
O58333 309AA LONG HYPOTHETICAL MODIFICATION METHYLASE - PYROCOCCUS HORIKOSHII.

MTTA_THEAQ MODIFICATION METHYLASE TAQI (EC 2.1.1.72) (ADENINE-SPECIFIC METHYLTRANSFERASE TAQI) (M.TAQI) - THERMUS AQUATICUS.
O25922 TYPE III RESTRICTION ENZYME M PROTEIN (MOD) - HELICOBACTER PYLORI (CAMPYLOBACTER PYLORI).
O32491 PUTATIVE N6-ADEININE SPECIFIC METHYLTRANSFERASE - BACTEROIDES NODOSUS (DICHELOBACTER NODOSUS).
O64360 GP52 - BACTERIOPHAGE N15.
P70724 AATII METHYLASE - ACETOBACTER ACETI.
P70802 METHYLASE - ANABAENA VARIABILIS.
Q58606 HYPOTHETICAL PROTEIN MJ1209 - METHANOCOCCUS JANNASCHII.
Scan History
OWL27_1    3  200  NSINGLE    
SPTR37_9f 4 190 NSINGLE
Initial Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
IDLIITDPPYNLG MTH1_HAEPA 22 22 -
IDLIFADPPYFMQ MTH1_HAEIN 30 30 -
IDMIFADPPYFLS MT1C_MORBO 33 33 -
VQLIICDPPYNIM MTR1_RHOSH 59 59 -
VQLAVIDPPYNLS MTM2_MORBO 24 24 -
VDMIYIDPPYNTG T3MO_SALTY 128 128 -
VDTIFADPPFNLD MTB1_BACAM 138 138 -
VNMIYIDPPYNTG T3MO_BPP1 117 117 -
IHAIISDIPYGID MTH3_HAEIN 22 22 -
AKLIYLDPPYATG MTEC_ENTCL 93 93 -
IDFCYIDPPYNTG MTK1_KLEPN 61 61 -
VKMIYIDPPYNTG T3MO_ECOLI 117 117 -
VKIAFFDPQYRGV MTH2_HAEHA 31 31 -

Motif 2 width=20
Element Seqn Id St Int Rpt
WLEECYRVLKPHGTIYIFMG MTH1_HAEPA 56 21 -
WLKECKRILKSTGSIWVIGS MTH1_HAEIN 78 35 -
WIAQARQLLKDNGTIWISGT MT1C_MORBO 80 34 -
WLAEAERVLSPTGSIAIFGG MTR1_RHOSH 88 16 -
WIDKVLDKLDKDGSLYIFNT MTM2_MORBO 56 19 -
RLFLARKLLKDTGFIFISID T3MO_SALTY 190 49 -
WIDECIRVLKPGGSLFIYNI MTB1_BACAM 173 22 -
RLYIARELLKEDGVIFISID T3MO_BPP1 181 51 -
WSNEWFRVLKSGSSVFVFAG MTH3_HAEIN 90 55 -
RLILMREILDDDGTIYVHIG MTEC_ENTCL 133 27 -
RLFHAHKMLKDTGIIAISID MTK1_KLEPN 103 29 -
RLYIARELMREDGTIFISID T3MO_ECOLI 181 51 -
FINEFERVLLPNGYLFLWVD MTH2_HAEHA 74 30 -

Motif 3 width=23
Element Seqn Id St Int Rpt
HPTQKPEALYERMILASSNEGDI MTH1_HAEPA 173 97 -
HSTQKPESLLYKVILSSSKPNDV MTH1_HAEIN 193 95 -
HPTQKPLGLLSRIILSSTQKDDL MT1C_MORBO 190 90 -
HPTQKPAAVIERLVRALSHPGST MTR1_RHOSH 223 115 -
HITPKPRDLIERIIRASSNPNDL MTM2_MORBO 193 117 -
FDTPKPTALLKKIIKLAIDKDGV T3MO_SALTY 390 180 -
KFNELSVKLLDRIITMSTNEGDV MTB1_BACAM 299 106 -
FEGPKPVPLITDLVKIGTKKDSL T3MO_BPP1 409 208 -
HVAQKPLNLMKLLIDLVTKEEQI MTH3_HAEIN 234 124 -
YPTEKNFNMMKLIVGASSNPGDL MTEC_ENTCL 322 169 -
FDTPKALNYIMSIINCMAKPDAL MTK1_KLEPN 318 195 -
FTNAKTIKLVEDLISFACDGEGI T3MO_ECOLI 415 214 -
HTHSKPIEMQKQLILATTQEGDL MTH2_HAEHA 169 75 -

Motif 4 width=15
Element Seqn Id St Int Rpt
VLDPFVGSGTLNFVC MTH1_HAEPA 196 0 -
VLDPFFGTGTTGAVA MTH1_HAEIN 216 0 -
ILDPFSGSGTTGIAG MT1C_MORBO 213 0 -
VLDFFAGSGVTARVA MTR1_RHOSH 246 0 -
VLDCFMGSGTTAIVA MTM2_MORBO 216 0 -
VLDFFAGSGTTAHAV T3MO_SALTY 413 0 -
VLDPFGGSGTTFAVS MTB1_BACAM 322 0 -
VLDFFAGSGTTAEAV T3MO_BPP1 432 0 -
VLDPFAGSGTTLLAA MTH3_HAEIN 257 0 -
VIDPFCGSGSTLHAA MTEC_ENTCL 345 0 -
ILDFFAGSGTTAHAA MTK1_KLEPN 341 0 -
VLDFFAGSGTTAHTV T3MO_ECOLI 438 0 -
ILDPASGGYSVFECC MTH2_HAEHA 192 0 -
Final Motifs
Motif 1  width=13
Element Seqn Id St Int Rpt
VDLIFADPPYNIG YHDJ_ECOLI 34 34 -
VDLIFADPPYNLQ Q45971 25 25 -
IDLIITDPPYNLG MTH1_HAEPA 22 22 -
VDVVFADPPYNLQ O30569 40 40 -
VDVIFADPPYNLQ O30570 40 40 -
MDMIFADPPYFLS MT22_STRPN 42 42 -
MDMIFADPPYFLS ML22_LACLC 42 42 -
IDLIFADPPYFMQ MTH1_HAEIN 30 30 -
VDFIFADPPYFMQ O25907 28 28 -
IDMIFADPPYFLS MT1C_MORBO 33 33 -
VRCIVTSPPYWGL MTC9_CITFR 45 45 -
IDLIIADPPYVVS P94454 45 45 -
VDLVVTSPPYNIN Q45489 55 55 -
VQLIICDPPYNIM MTR1_RHOSH 59 59 -
VRCVVTSPPYWGL MTX1_XANCC 45 45 -
VRCVVTSPPYWGL P96424 106 106 -
VRCVVTSPPYWGL O68565 45 45 -
VQLAVIDPPYNLS MTM2_MORBO 24 24 -
VDMIYIDPPYNTG T3MO_SALTY 128 128 -
ADLVYLDPPFFTN O68568 27 27 -
VDLIITSPPYFNI O25921 22 22 -
IHLILSDIPYGIS O86267 23 23 -
VDTIFADPPFNLD MTB1_BACAM 138 138 -
VDFILTDPPYLVG O68789 9 9 -
VKLIYIDPPYNTG P71366 143 143 -
FDLIFADPPYFLS O24918 39 39 -
VDFILTDPPYLVG O82897 21 21 -
VDVVVTSPPYNIG MT42_METJA 23 23 -
VDLAIIDPPYNLK O25920 23 23 -
FDCVVTSPPYWGL MTSM_SERMA 44 44 -
VDLFITDPPYESL Q56638 34 34 -
VNMIYIDPPYNTG T3MO_BPP1 117 117 -
VNLVFTSPPYYNA MTC1_CITFR 132 132 -
VDLFITDPPYESL Q08802 21 21 -
YRLAVTSPPYYGH O74074 35 35 -
YRLAVTSPPYYGH O74053 29 29 -
AHLILSDIPYGIG Q46975 33 33 -
VHLVVTSPPYPMI MTM1_METJA 28 28 -
IALSVWSPPYHVG O68556 29 29 -
IDLTVTSPPYDDL MTB2_BACAM 10 10 -
IHAIISDIPYGID MTH3_HAEIN 22 22 -
IQTIYIDPPYNTK O25040 21 21 -
IKMIYIDPPYNTG O25315 98 98 -
VDAIVTDPPYGET O03956 31 31 -
VHMVMTSPPYFGL Q38206 50 50 -
VQLVYIDPPYGTG O51937 94 94 -
AKLIYLDPPYATG MTEC_ENTCL 93 93 -
INLVVTSPPYPMV MTHZ_METTF 23 23 -
VQTIYIDPPFNKE O28863 448 448 -
INTVVTSPPYWAV O52513 48 48 -
IDFCYIDPPYNTG MTK1_KLEPN 61 61 -
VKMIYIDPPYNTG T3MO_ECOLI 117 117 -
ISLVMTSPPFALQ MTP2_PROVU 47 47 -
VKIAFFDPQYRGV MTH2_HAEHA 31 31 -

Motif 2 width=20
Element Seqn Id St Int Rpt
VIAECHRVLKKQGSMYIMNS YHDJ_ECOLI 68 21 -
WLKAARRVLKDDGAIWVIGS Q45971 73 35 -
WLEECYRVLKPHGTIYIFMG MTH1_HAEPA 56 21 -
WLLACRRVLKPTGTLWVIGS O30569 88 35 -
WLLACRRVLKPNGTIWVIGS O30570 88 35 -
WIRLAKEVLKPNGTVWISGS MT22_STRPN 89 34 -
WIRLARLVLKPNGTIWVSGS ML22_LACLC 89 34 -
WLKECKRILKSTGSIWVIGS MTH1_HAEIN 78 35 -
WLKECQRILKDNGSICVIGS O25907 76 35 -
WIAQARQLLKDNGTIWISGT MT1C_MORBO 80 34 -
IFSEAKRVLTDDGTLWVNIG MTC9_CITFR 82 24 -
WISFAYKVLKPSGSLIVFND P94454 89 31 -
IIEQCHRVLKPSGSIFWQVG Q45489 86 18 -
WLAEAERVLSPTGSIAIFGG MTR1_RHOSH 88 16 -
IFAEVKRVLTDDGTLWLNIG MTX1_XANCC 82 24 -
IFAEVRRVLTDDGTLWLNIG P96424 143 24 -
IFAEVKRVLTDDGTLWLNIG O68565 82 24 -
WIDKVLDKLDKDGSLYIFNT MTM2_MORBO 56 19 -
RLFLARKLLKDTGFIFISID T3MO_SALTY 190 49 -
RLREAHRVLKHSGSIFVHCD O68568 72 32 -
VWLECYRALKPNGKLCINVP O25921 71 36 -
WAKEWFRVLKPGSSCFIFAG O86267 92 56 -
WIDECIRVLKPGGSLFIYNI MTB1_BACAM 173 22 -
ACHEMYRVLKKDALMVSFYG O68789 42 20 -
RLEIAKTLLADDGVIFVQCD P71366 177 21 -
WINNAKKALKDTGSLLISGT O24918 86 34 -
ACNEMYRVLKKDALMVSFYG O82897 54 20 -
VVKEIKRVLKDDGSFFINVG MT42_METJA 57 21 -
WIDKMLPKLKDTGSFYIFNT O25920 55 19 -
LFRDVRRTLKDDGTLWLNIG MTSM_SERMA 81 24 -
LFREVYRVLKKGSHFYLFCD Q56638 80 33 -
RLYIARELLKEDGVIFISID T3MO_BPP1 181 51 -
VIKECHRVLSEGRFFVINVS MTC1_CITFR 164 19 -
LFREVYRVLKKGSHFYLFCD Q08802 67 33 -
VFKSCMDLLTDDGSLFIVIG O74074 73 25 -
VFKSCMDLLTDDGSLFIVIG O74053 67 25 -
WATEWFRVLKPGASAIIFAG Q46975 102 56 -
VWEEVYRVLVPGGIACINIG MTM1_METJA 88 47 -
VIALHYPILKPGGFLVINID O68556 60 18 -
TAQELYRVTKEGGVVVWVVG MTB2_BACAM 35 12 -
WSNEWFRVLKSGSSVFVFAG MTH3_HAEIN 90 55 -
HLILAKAVLKQSGCLFISMD O25040 53 19 -
RLKLARDLLKEDGVIFISID O25315 170 59 -
WPGLVRPLLKRTGSMWCFGS O03956 54 10 -
VAEQLRRVLRPDGSWWLNLG Q38206 87 24 -
RLILLRELMADSGLIFVHID O51937 148 41 -
RLILMREILDDDGTIYVHIG MTEC_ENTCL 133 27 -
VWHEVDRVTAPGGVVIINIG MTHZ_METTF 73 37 -
RIRLGRELLNERGSIFVRCD O28863 483 22 -
IFREVYRVLATDGSAWLNIG O52513 85 24 -
RLFHAHKMLKDTGIIAISID MTK1_KLEPN 103 29 -
RLYIARELMREDGTIFISID T3MO_ECOLI 181 51 -
FAKVVNKKLKPDGSFVVDFG MTP2_PROVU 79 19 -
FINEFERVLLPNGYLFLWVD MTH2_HAEHA 74 30 -

Motif 3 width=23
Element Seqn Id St Int Rpt
HPTQKPEALLKRIILASSNPGDI YHDJ_ECOLI 195 107 -
HPTQKPEALLYRVILSTTKPGDV Q45971 189 96 -
HPTQKPEALYERMILASSNEGDI MTH1_HAEPA 173 97 -
HPTQKPEALLARILMASTKPGDV O30569 204 96 -
HPTQKPEALLARIMMASSKPGDV O30570 204 96 -
HPTQKPEYLLERIILASTKEGDY MT22_STRPN 200 91 -
HPTQKPEYILERIILASTKENDY ML22_LACLC 200 91 -
HSTQKPESLLYKVILSSSKPNDV MTH1_HAEIN 193 95 -
HSTQKPEALLKKIILSATKPKDI O25907 191 95 -
HPTQKPLGLLSRIILSSTQKDDL MT1C_MORBO 190 90 -
HFATFPTELIRPCILASTKPGDY MTC9_CITFR 226 124 -
HPTQKPVKLIEYLIRIHSNENDI P94454 190 81 -
HPTQYPEDMIERIVLSTTEPNDI Q45489 221 115 -
HPTQKPAAVIERLVRALSHPGST MTR1_RHOSH 223 115 -
HFTTFPPELIRPCIHASTEPGDY MTX1_XANCC 226 124 -
HFATFPPDLIRPCIQASTEPGDY P96424 287 124 -
HFATFPPELIRPCIHASTEPGDY O68565 226 124 -
HITPKPRDLIERIIRASSNPNDL MTM2_MORBO 193 117 -
FDTPKPTALLKKIIKLAIDKDGV T3MO_SALTY 390 180 -
YPTQKPILLLERIIEISTDPGDF O68568 215 123 -
HAALMPAELARRLIRLYSCVGDV O25921 219 128 -
HPTQKPLVLMKALIELTTQENQI O86267 231 119 -
KFNELSVKLLDRIITMSTNEGDV MTB1_BACAM 299 106 -
HPTEKPVTSLQPLIESFTHPGAI O68789 132 70 -
KNGKKPEALLRRIIDMTTKEGDI P71366 432 235 -
HPTQKPLALLVRLLLMASDENSL O24918 196 90 -
HPTEKPVTSLQPLIESFTHPNAI O82897 144 70 -
HPATFPPKLPEMCIKLHGVKKTN MT42_METJA 204 127 -
HPSIKPKALIERMIKASSHKNDL O25920 193 118 -
HFAVFPRAMARLCVLAGSRPGGK MTSM_SERMA 227 126 -
YPTEKPVELLEVLIRQSSSENEI Q56638 169 69 -
FEGPKPVPLITDLVKIGTKKDSL T3MO_BPP1 409 208 -
HPATFPYGLAERVIKYYSFKNDV MTC1_CITFR 305 121 -
YPTEKPVELLEVLIRQSSSENEI Q08802 156 69 -
HFAVFPEDLVSRIVKFATKEGDY O74074 281 188 -
HFAVFPEDLVSRIVKFATREGDY O74053 275 188 -
HPTQKPVALMKTLIELTTQKGQL Q46975 241 119 -
RTASFPEEIPRRLIRMFSIIGDT MTM1_METJA 223 115 -
HEAKFPLLLPQRLIKLLTQKGDT O68556 245 165 -
HPAIFPEKLAEDHILSWSNEGDI MTB2_BACAM 182 127 -
HVAQKPLNLMKLLIDLVTKEEQI MTH3_HAEIN 234 124 -
FKTPKPVALIKYLLLCSTPKDSI O25040 285 212 -
FTYPKGVEFMKKIILHSTTPNEG O25315 377 187 -
NETQKPVALVEPLVRNACPPGGL O03956 187 113 -
HFAVYPPELCEVPIKSSCPPVVC Q38206 268 161 -
YPTEKNLDMLKLIVQTGSNEGDL O51937 335 167 -
YPTEKNFNMMKLIVGASSNPGDL MTEC_ENTCL 322 169 -
RAAAYPFELAYRLINMYSIMGDW MTHZ_METTF 213 120 -
FSTENSEILLKRVIESTSNEGDL O28863 708 205 -
HFAVMPRKLAHFALKATLPMNGS O52513 349 244 -
FDTPKALNYIMSIINCMAKPDAL MTK1_KLEPN 318 195 -
FTNAKTIKLVEDLISFACDGEGI T3MO_ECOLI 415 214 -
HPARFPAKLPEFFIRMLTEPDDL MTP2_PROVU 246 147 -
HTHSKPIEMQKQLILATTQEGDL MTH2_HAEHA 169 75 -

Motif 4 width=15
Element Seqn Id St Int Rpt
VLDPFAGSFTTGAVA YHDJ_ECOLI 218 0 -
ILDPFFGVGTTGAAA Q45971 212 0 -
VLDPFVGSGTLNFVC MTH1_HAEPA 196 0 -
VLDPFFGSGTTGAVA O30569 227 0 -
ILDPFFGSGTTGAVA O30570 227 0 -
ILDPFVGSGTTGVVA MT22_STRPN 223 0 -
ILDPFVGSGTTGVVA ML22_LACLC 223 0 -
VLDPFFGTGTTGAVA MTH1_HAEIN 216 0 -
ILDPFFGTGTTGAVA O25907 214 0 -
ILDPFSGSGTTGIAG MT1C_MORBO 213 0 -
VLDPFFGSGTVGVVC MTC9_CITFR 249 0 -
ILDPFMGSGTTGVAS P94454 213 0 -
VLDPFIGMGTTASVA Q45489 244 0 -
VLDFFAGSGVTARVA MTR1_RHOSH 246 0 -
VLDPFFGSGTVGLVC MTX1_XANCC 249 0 -
VLDPFFGSGTVGLVC P96424 310 0 -
VLDPFFGSGTVGLVC O68565 249 0 -
VLDCFMGSGTTAIVA MTM2_MORBO 216 0 -
VLDFFAGSGTTAHAV T3MO_SALTY 413 0 -
IVDPFCGSGTTLVAA O68568 238 0 -
VLDPFSGSGTTLREA O25921 242 0 -
VLDPFSGSGTTLVAA O86267 254 0 -
VLDPFGGSGTTFAVS MTB1_BACAM 322 0 -
VLDPFAGSGSTCVAA O68789 155 0 -
VLDYHLGSGTTAAVA P71366 455 0 -
IGDPFSGSSTTGIAA O24918 219 0 -
VLDPFAGSGSTCVAA O82897 167 0 -
VLDPFMGIGSTAIAC MT42_METJA 228 1 -
ILDLFSGSGMTSLVA O25920 216 0 -
VLDPFFGSGTTGVVC MTSM_SERMA 250 0 -
VADSFFGSGSTLIAA Q56638 192 0 -
VLDFFAGSGTTAEAV T3MO_BPP1 432 0 -
ILDPFAGSGTTAKAA MTC1_CITFR 328 0 -
VADSFFGSGATLIAA Q08802 179 0 -
VLDPFAGRGTTGIVS O74074 304 0 -
VLDPFAGRGTTGIVS O74053 298 0 -
VIDPFSGSGSTLVAA Q46975 264 0 -
VLDPFLGTGTTVKAA MTM1_METJA 246 0 -
VLDCFMGSGTTAVAA O68556 268 0 -
VFDPFMGSGTTAKMA MTB2_BACAM 205 0 -
VLDPFAGSGTTLLAA MTH3_HAEIN 257 0 -
ILDFFAGSGTTAQAV O25040 308 0 -
ILDFFAGSGTTVHAV O25315 402 2 -
VADFFAGSGSTALAC O03956 210 0 -
VLDPFAGAGTTCLSA Q38206 406 115 -
VLDPFAGSGTTLIAS O51937 358 0 -
VIDPFCGSGSTLHAA MTEC_ENTCL 345 0 -
VLDPFLGTGTTMIAA MTHZ_METTF 236 0 -
VLDFFLGSGTTTAVA O28863 731 0 -
CLDPFMGSGTTGRVV O52513 372 0 -
ILDFFAGSGTTAHAA MTK1_KLEPN 341 0 -
VLDFFAGSGTTAHTV T3MO_ECOLI 438 0 -
VVDIFGGSNTTGLVA MTP2_PROVU 269 0 -
ILDPASGGYSVFECC MTH2_HAEHA 192 0 -