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PR00489

Identifier
FRIZZLED  [View Relations]  [View Alignment]  
Accession
PR00489
No. of Motifs
7
Creation Date
22-MAR-1996  (UPDATE 28-JUL-1999)
Title
Frizzled protein signature
Database References
PRINTS; PR90007 7TM
INTERPRO; IPR000539
Literature References
1. VINSON, C.R., CONOVER, S. AND ADLER, P.N.
A Drosophila tissue polarity locus encodes a protein containing seven
potential transmembrane domains.
NATURE 338 263-264 (1989).
 
2. ADLER, P.N., VINSON, C., PARK, W.J., CONOVER, S. AND KLEIN, L.
Molecular structure of frizzled, a Drosophila tissue polarity gene.
GENETICS 126 401-416 (1990).

Documentation
The frizzled (fz) locus of Drosophila coordinates the cytoskeletons of
epidermal cells, producing a parallel array of cuticular hairs and bristles
[1,2]. In fz mutants, the orientation of individual hairs with respect both
to their neighbours and to the organism as a whole is altered - in the wild-
type wing, all hairs point towards the distal tip [1]. In the developing
wing, fz has 2 functions: it is required for the proximal-distal
transmission of an intracellular polarity signal; and it is required for
cells to respond to the polarity signal.
 
Fz produces an mRNA that encodes an integral membrane protein with 7
putative transmembrane (TM) domains. This protein should contain both
extracellular and cytoplasmic domains, which could function in the
transmission and interpretation of polarity information [1]. 
 
FRIZZLED is a 7-element fingerprint that provides a signature for frizzled
proteins. The fingerprint was derived from an initial alignment of 5 
sequences: the motifs were drawn from the 7 putative TM regions. Two
iterations on OWL27.1 were required to reach convergence, at which point
a true set comprising 12 sequences was identified. A single partial match
was also found, a frizzled protein fragment lacking the last 3 motifs.
 
An update on SPTR37_9f identified a true set of 25 sequences, and 1
partial match.
Summary Information
  25 codes involving  7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
1 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
725252525252525
60000000
50000000
40000000
31101000
20000000
1234567
True Positives
FRIZ_DROME    O00144        O16147        O16190        
O42579 O57328 O57329 O60353
O70421 O75084 O93274 P91682
P97698 Q08463 Q08464 Q13467
Q14332 Q61086 Q61088 Q61089
Q61090 Q61091 Q94132 Q94916
Q99835
True Positive Partials
Codes involving 3 elements
O77438
Sequence Titles
FRIZ_DROME  FRIZZLED PROTEIN PRECURSOR - DROSOPHILA MELANOGASTER (FRUIT FLY). 
O00144 FRIZZLED HOMOLOG - HOMO SAPIENS (HUMAN).
O16147 MOM-5 - CAENORHABDITIS ELEGANS.
O16190 F27E11.3 PROTEIN - CAENORHABDITIS ELEGANS.
O42579 FRIZZLED 3 PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
O57328 7-TRANSMEMBRANE PROTEIN FRIZZLED-1 - GALLUS GALLUS (CHICKEN).
O57329 7-TRANSMEMBRANE PROTEIN FRIZZLED-7 - GALLUS GALLUS (CHICKEN).
O60353 FRIZZLED-6 - HOMO SAPIENS (HUMAN).
O70421 FRIZZLED-1 - MUS MUSCULUS (MOUSE).
O75084 FZE3 - HOMO SAPIENS (HUMAN).
O93274 FRIZZLED 8 PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
P91682 SMOOTHENED PROTEIN PRECURSOR (SEVEN-PASS MEMBRANE PROTEIN) (DSMO) (SMOH) (SMOOTH) - DROSOPHILA MELANOGASTER (FRUIT FLY).
P97698 SMOOTHENED HOMOLOG PRECURSOR (SEVEN-PASS MEMBRANE PROTEIN) (SMO) - RATTUS NORVEGICUS (RAT).
Q08463 FRIZZLED PROTEIN HOMOLOG 1 (FZ-1) - RATTUS NORVEGICUS (RAT).
Q08464 FRIZZLED PROTEIN HOMOLOG 2 PRECURSOR (FZ-2) - RATTUS NORVEGICUS (RAT).
Q13467 TRANSMEMBRANE RECEPTOR - HOMO SAPIENS (HUMAN).
Q14332 FRIZZLED GENE PRODUCT - HOMO SAPIENS (HUMAN).
Q61086 FRIZZLED-3 - MUS MUSCULUS (MOUSE).
Q61088 FRIZZLED HOMOLOG 4 (TRANSMEMBRANE RECEPTOR) - MUS MUSCULUS (MOUSE).
Q61089 FRIZZLED HOMOLOG 6 (TRANSMEMBRANE RECEPTOR) - MUS MUSCULUS (MOUSE).
Q61090 FRIZZLED HOMOLOG 7 (TRANSMEMBRANE RECEPTOR) - MUS MUSCULUS (MOUSE).
Q61091 FRIZZLED HOMOLOG 8 (TRANSMEMBRANE RECEPTOR) - MUS MUSCULUS (MOUSE).
Q94132 TRANSMEMBRANE RECEPTOR LIN-17 - CAENORHABDITIS ELEGANS.
Q94916 DFZ2 - DROSOPHILA MELANOGASTER (FRUIT FLY).
Q99835 SMOOTHENED HOMOLOG PRECURSOR (SEVEN-PASS MEMBRANE PROTEIN) (SMO) - HOMO SAPIENS (HUMAN).

O77438 EG:34F3.6 PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
Scan History
OWL27_1    2  100  NSINGLE    
SPTR37_9f 4 50 NSINGLE
Initial Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
WILTWSVLCCASTFFTVTTSLVA RATFRZH 252 252 -
WILTWSVLCCASTFFTVTTYLVD HUMFRIZ 247 247 -
WIGIWSVLCCASTLFTVLTYLVD RATFRZZH 316 316 -
WVGSWAAICVATCLFTVLTFLID DROTPP 254 254 -
WVGSWAAVCVASCLFTVLTFLID FRIZ_DROME 249 249 -

Motif 2 width=23
Element Seqn Id St Int Rpt
YPERAIVFLAVCYLVVGCAYVAG DROTPP 282 5 -
YPERPIIFLSGCYTAVAVAYIAG RATFRZZH 344 5 -
YPERPIIFLSGCYTMVSVAYIAG HUMFRIZ 275 5 -
YPERPIIFLSGCYTMVSVAYIAG RATFRZH 280 5 -
YPERAIVFLAVCYLVVGCAYVAG FRIZ_DROME 277 5 -

Motif 3 width=25
Element Seqn Id St Int Rpt
ILFMMLYFFSMASSIWWVILSLTWF HUMFRIZ 329 31 -
VLFMALYFCCMAAFAWWSCLAFAWF FRIZ_DROME 339 39 -
ILFMMLYFFSMASSIWWVILSLTWF RATFRZZH 398 31 -
VLFMALYFCCMAAFAWWSCLAFAWF DROTPP 344 39 -
ILFMMLYFFSMASSIWWVILSLTWF RATFRZH 334 31 -

Motif 4 width=24
Element Seqn Id St Int Rpt
FHLAAWAVPAVKTITILAMGQIDG RATFRZH 377 18 -
FHLAAWAVPAVKTITILAMGQIDG HUMFRIZ 372 18 -
FHLVAWAVPALQTISVLALAKVEG DROTPP 387 18 -
FHLAAWAVPAIKTITILALGQVDG RATFRZZH 441 18 -
FHLVAWAVPALQTISVLALAKVEG FRIZ_DROME 382 18 -

Motif 5 width=23
Element Seqn Id St Int Rpt
ILPLCIYLSIGALFLLAGFISLF DROTPP 432 21 -
LAPLFVYLFIGTSFLLAGFVSLF RATFRZZH 486 21 -
LAPLFVYLFIGTSFLLAGFVSLF HUMFRIZ 417 21 -
LAPLFVYLFIGTSFLLAGFVSLF RATFRZH 422 21 -
ILPLCIYLSIGALFLLAGFISLF FRIZ_DROME 427 21 -

Motif 6 width=22
Element Seqn Id St Int Rpt
LMLRIGFFSGLFILPGLGLLGC DROTPP 473 18 -
LMVRIGVFSVLYTVPATIVIAC RATFRZZH 527 18 -
LMVRIGVFSVLYTVPATIVIAC RATFRZH 463 18 -
LMLRIGFFSGLFILPAVGLLGC FRIZ_DROME 468 18 -
LMVRIGVFSVLYTVPATIVIAC HUMFRIZ 458 18 -

Motif 7 width=21
Element Seqn Id St Int Rpt
VFMIKYLMTLIVGITSGFWIW RATFRZZH 596 47 -
VYMIKYLMTLIVGITSGFWIW HUMFRIZ 520 40 -
VYMIKYLMTLIVGITSGFWIW RATFRZH 525 40 -
IFMVKYLCSMLVGVTSSVWLY FRIZ_DROME 533 43 -
IYMVKYLCSMLVGVTSSVWLY DROTPP 538 43 -
Final Motifs
Motif 1  width=23
Element Seqn Id St Int Rpt
WIGIWSVLCCASTLFTVLTYLVD Q08463 316 316 -
WIGIWSVLCCASTLFTVLTYLVD O57328 271 271 -
WVGVWSVLCCASTLFTVLTYLVD O57329 250 250 -
WILTWSVLCCASTFFTVTTYLVD Q14332 247 247 -
WVGVWSVLSCASTLFTVLTYLVD Q61090 254 254 -
WILTWSVLCCASTFFTVTTSLVA Q08464 252 252 -
WVGVWSVLCCASTLFTVLTYLVD O75084 256 256 -
WIGLWSVLCFASTFATVSTFLID O93274 239 239 -
WIGIWSVLCCASTLFTVLTYLVD O70421 317 317 -
WIGLWSVLCFVSTFATVSTFLID Q61091 277 277 -
WIGLWSVLCFISTSTTVATFLID Q13467 238 238 -
WIALWSGLCFCSTLMTLTTFIID Q94916 320 320 -
WMAVWASLCFISTTFTVLTFLID Q61088 222 222 -
WMAVWSALCFFSTAFTVLTFLLE O00144 234 234 -
FIGLISIICLSATLFTFLTFLID Q61086 205 205 -
FIGTVSIFCLCATLFTFLTFLID O60353 201 201 -
FIGVISIVCLSATLFTFLTFLID O42579 204 204 -
FIGIVSIFCLCATLFTFLTFLID Q61089 201 201 -
WVGSWAAVCVASCLFTVLTFLID FRIZ_DROME 249 249 -
WMAFWSITCCVLASFTFLTFLIE O16190 197 197 -
WTAAWSVACFVCSLFTLVTFLVD O16147 230 230 -
YIAAFGAVTGLCTLFTLATFVAD Q99835 233 233 -
YIAAFGAVTGLCTLFTLATFVAD P97698 237 237 -
LIGWAGSICLLSNLFVVSTFFID P91682 258 258 -
WSIWFAAANAGVALFSFLTFAID Q94132 207 207 -

Motif 2 width=23
Element Seqn Id St Int Rpt
YPERPIIFLSGCYTAVAVAYIAG Q08463 344 5 -
YPERPIIFLSGCYTAVAVAYIAG O57328 299 5 -
YPERPIIFLSGCYFMVAVAYAAG O57329 278 5 -
YPERPIIFLSGCYTMVSVAYIAG Q14332 275 5 -
YPERPIIFLSGCYFMVAVAHVAG Q61090 282 5 -
YPERPIIFLSGCYTMVSVAYIAG Q08464 280 5 -
YPERPIIFLSGCYFMVAVAHVAG O75084 284 5 -
YPERPIIFLSACYLLVSTGYLIR O93274 267 5 -
YPERPIISLSGCYTAVAVAYIAG O70421 345 5 -
YPERPIIFLSACYLFVSVGYLVR Q61091 305 5 -
YPERPIIFLSACYLCVSLGFLVR Q13467 266 5 -
YPERPIVFLSACYFMVAVGYLSR Q94916 348 5 -
YPERPIIFLSMCYNIYSIAYIVR Q61088 250 5 -
YPERPIIFLSMCYNVYSLAFLIR O00144 262 5 -
YPERPIIFYAVCYMMVSLIFFIG Q61086 233 5 -
YPERPIIYYSVCYSIVSLMYFIG O60353 229 5 -
YPERPIIFYAVCYMMVSLIFFIG O42579 232 5 -
YPERPIIYYSVCYSIVSLMYFVG Q61089 229 5 -
YPERAIVFLAVCYLVVGCAYVAG FRIZ_DROME 277 5 -
YPERPIFMLAFCQLMVAVGFMIR O16190 225 5 -
YPVRPILYLAFCYLAISTVYMIG O16147 258 5 -
YPAVILFYVNACFFVGSIGWLAQ Q99835 262 6 -
YPAVILFYVNACFFVGSIGWLAQ P97698 266 6 -
YPAVIVFYINLCFLIACVGWLLQ P91682 287 6 -
FPERCVFYLSLCIFISSLPYLTP Q94132 235 5 -

Motif 3 width=25
Element Seqn Id St Int Rpt
ILFMMLYFFSMASSIWWVILSLTWF Q08463 398 31 -
ILFMMLYFFGMASSIWWVILSLTWF O57328 353 31 -
ILFMILYFFGMASSIWWVILSLTWF O57329 332 31 -
ILFMMLYFFSMASSIWWVILSLTWF Q14332 329 31 -
ILFMVLYFFGMASSIWWVILSLTWF Q61090 336 31 -
ILFMMLYFFSMASSIWWVILSLTWF Q08464 334 31 -
ILFMVLYFFGMASSIWWVILSLTWF O75084 338 31 -
LVFLLIYFFGMASSIWWVILSLTWF O93274 322 32 -
ILFMMLYFFSMASSIWWVILSLTWF O70421 399 31 -
VVFLLVYFFGMASSIWWVILSLTWF Q61091 396 68 -
IVFLLVYFFGMASSIWWVILSLTWF Q13467 317 28 -
LVFLLTYFFGMASSIWWVILTFTWF Q94916 397 26 -
IIFLLMYFFGMASSIWWVILTLTWF Q61088 304 31 -
LVFLLLYYFGMASSLWWVVLTLTWF O00144 315 30 -
MLFMVLYFFTMAGSVWWVILTITWF Q61086 288 32 -
VLFMLLYFFTMAGTVWWVILTITWF O60353 284 32 -
MLFMVLYFFTMAGSVWWVILTITWF O42579 287 32 -
VVFMFLYFFTMAGTVWWVILTITWF Q61089 284 32 -
VLFMALYFCCMAAFAWWSCLAFAWF FRIZ_DROME 339 39 -
VVFLLTYFFGMAASVWWVILSLTWV O16190 275 27 -
ALAVVHYFFFMSSCAWWLVLCLAWF O16147 311 30 -
IIFVIVYYALMAGVVWFVVLTYAWH Q99835 316 31 -
IIFVIVYYALMAGVVWFVVLTYAWH P97698 320 31 -
VIFVLVYYFLTAGMVWFVFLTYAWH P91682 341 31 -
ASFLLNYFFSTAAALWWLMFSFTLY Q94132 289 31 -

Motif 4 width=24
Element Seqn Id St Int Rpt
FHLAAWAVPAIKTITILALGQVDG Q08463 441 18 -
FHLAAWAVPAIKTITILALGQVDG O57328 396 18 -
FHLAAWAVPAVKTITILAMGQVDG O57329 375 18 -
FHLAAWAVPAVKTITILAMGQIDG Q14332 372 18 -
FHLAAWAVPAVKTITILAMGQVDG Q61090 379 18 -
FHLAAWAVPAVKTITILAMGQIDG Q08464 377 18 -
FHLAAWAVPAVKTITILAMGQVDG O75084 381 18 -
FHLAAWLVPSIKSIAVLALSSVDG O93274 365 18 -
FHLAAWAVPAIKTITILALGQVDG O70421 442 18 -
FHLAAWLVPSVKSIAVLALSSVDG Q61091 439 18 -
FHLAAWLIPSVKSITALALSSVDG Q13467 360 18 -
FHLAAWLIPTVQSVAVLLLSAVDG Q94916 440 18 -
FHIAAWAIPAVKTIVILIMRLVDA Q61088 347 18 -
FHMAAWGLPALKTIVILTLRKVAG O00144 358 18 -
FHASAWGIPGTLTIILLAMNKIEG Q61086 331 18 -
FHAVAWGTPGFLTVMLLALNKVEG O60353 327 18 -
FHASAWGIPGTLTIILLAMNKIEG O42579 330 18 -
FHAVAWGAPGFLTVMLLAMNKVEG Q61089 327 18 -
FHLVAWAVPALQTISVLALAKVEG FRIZ_DROME 382 18 -
FHVVGWCLPAIQTVLVIVFNAIDG O16190 318 18 -
FHAMCWGVPAVLSVTVLVTNSVDG O16147 354 18 -
FHLLTWSLPFVLTVAILAVAQVDG Q99835 360 19 -
FHLLTWSLPFVLTVAILAVAQVDG P97698 364 19 -
FHLVAWSLPLVLTITTMAFSEVDG P91682 383 17 -
VHFVAWGLSSLATIIVLIFNKVDA Q94132 332 18 -

Motif 5 width=23
Element Seqn Id St Int Rpt
LAPLFVYLFIGTSFLLAGFVSLF Q08463 486 21 -
LAPLFVYLFIGTSFLLAGFVSLF O57328 441 21 -
LAPLFVYLFIGTSFLLAGFVSLF O57329 420 21 -
LAPLFVYLFIGTSFLLAGFVSLF Q14332 417 21 -
LAPLFVYLFIGTSFLLAGFVSLF Q61090 424 21 -
LAPLFVYLFIGTSFLLAGFVSLF Q08464 422 21 -
LAPLFVYFFIGTSFLLAGFVSFF O75084 426 21 -
LAPLVIYLFIGSMFLLAGFVSLF O93274 410 21 -
LAPLFVYLFIGTSFLLAGFVSLF O70421 487 21 -
LAPLVIYLFIGTMFLLAGFVSLF Q61091 484 21 -
LGPLVLYLLVGTLFLLAGFVSLF Q13467 405 21 -
LAPLFVYLVIGTTFLMAGFVSLF Q94916 485 21 -
VAPLFTYLVIGTLFIAAGLVALF Q61088 392 21 -
LVPLSGYLVLGSSFLLTGFVALF O00144 403 21 -
LAPLCLYVVVGVSLLLAGIISLN Q61086 376 21 -
LLPLCLCVFVGLSLLLAGIISLN O60353 372 21 -
LAPLCLDVVVGVSLLLAGIISLN O42579 375 21 -
LLPLCLCVFVGLSLLLAGIISLN Q61089 372 21 -
ILPLCIYLSIGALFLLAGFISLF FRIZ_DROME 427 21 -
LFPLLVYFIVGVLFLVIGFCNLW O16190 363 21 -
FTPIVVSLALGAVLLVCGIWSMI O16147 399 21 -
LAPIGLVLIVGGYFLIRGVMTLF Q99835 405 21 -
LAPIGLVLIVGGYFLIRGVMTLF P97698 409 21 -
LGPLCGVILIGGYFITRGMVMLF P91682 428 21 -
IVPRTICIVIGTCFIVGGFASMC Q94132 377 21 -

Motif 6 width=22
Element Seqn Id St Int Rpt
LMVRIGVFSVLYTVPATIVIAC Q08463 527 18 -
LMVRIGIFSVLYTVPATIVIAC O57328 482 18 -
LMVRIGVFSVLYTVPATIVVAC O57329 461 18 -
LMVRIGVFSVLYTVPATIVIAC Q14332 458 18 -
LMVRIGVFSVLYTVPATIVLAC Q61090 465 18 -
LMVRIGVFSVLYTVPATIVIAC Q08464 463 18 -
LMVRIGVFSVLYTVPATIVLAC O75084 467 18 -
LMIRIGIFSVLYTVPATIVVAC O93274 451 18 -
LMVRIGVFSVLYTVPATIVIAC O70421 528 18 -
LMIRLGLFTVLYTVPAAVVVAC Q61091 527 20 -
LMIRIGIFTLLYTVPASIVVAC Q13467 446 18 -
LMIRIGIFSVLYTVPATIVIGC Q94916 531 23 -
LMVKIGVFSVLYTVPATCVIAC Q61088 433 18 -
LMVKIGVFSILYTVPATCVIVC O00144 444 18 -
FMIRIGVFSILYLVPLLVVIGC Q61086 417 18 -
FMIRIGVFSGLYLVPLVTLLGC O60353 413 18 -
FMIRIGVFSILYLVPLLVVIGC O42579 416 18 -
FMIRIGVFSGLYLVPLVTLLGC Q61089 413 18 -
LMLRIGFFSGLFILPAVGLLGC FRIZ_DROME 468 18 -
LMSKIGIFSLLYTIPSLLIICV O16190 407 21 -
LMLRIGAFAIMYSLPTAMNAAI O16147 444 22 -
TMLRLGIFGFLAFGFVLITFSC Q99835 448 20 -
TMLRLGIFGFLAFGFVLITFSC P97698 452 20 -
IIMRMGVCALLTLVFILVAIAC P91682 471 20 -
LMVKMGFFCALFILPNVIELVC Q94132 418 18 -

Motif 7 width=21
Element Seqn Id St Int Rpt
VFMIKYLMTLIVGITSGFWIW Q08463 596 47 -
VFMIKYLMTLIVGITSGFWIW O57328 547 43 -
VFMIKYLMTMIVGITTGFWIW O57329 522 39 -
VYMIKYLMTLIVGITSGFWIW Q14332 520 40 -
VFMIKYLMTMIVGITTGFWIW Q61090 527 40 -
VYMIKYLMTLIVGITSGFWIW Q08464 525 40 -
VFMIKCLMTMIVGITTGFWIW O75084 529 40 -
VFMLKYFMCLVVGITSGVWIW O93274 506 33 -
VFMIKYLMTLNSWRKFYTRLT O70421 597 47 -
VFMLKYFMCLVVGITSGVWVW Q61091 583 34 -
VLMLKYFMCLVVGITSGVWIW Q13467 502 34 -
VLMLKYFMALAVGITSGVWIW Q94916 585 32 -
VEMLKIFMSLLVGITSGMWIW Q61088 476 21 -
VFMLKIFMSLVVGITSGVWVW O00144 509 43 -
LFLMKYLMALIVGIPSIFWVG Q61086 479 40 -
LFMIKYLMTLIVGISAVFWVG O60353 475 40 -
LFLMKYLMLLVVGIPSVFWVG O42579 478 40 -
LFMIKYLMTLIVGISAVFWVG Q61089 475 40 -
IFMVKYLCSMLVGVTSSVWLY FRIZ_DROME 533 43 -
ISLIKTCCMCILGWTSGFWVC O16190 526 97 -
VFLLKYVSQLVVGITCAIWVV O16147 516 50 -
VEKINLFAMFGTGIAMSTWVW Q99835 517 47 -
VEKINLFAMFGTGIAMSTWVW P97698 521 47 -
VLQLHLLCLFSSGIVMSTWCW P91682 535 42 -
IYMTAVISSLATGFSCLMWVL Q94132 474 34 -