Identifier | FRIZZLED  [View Relations]  [View Alignment]  
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Accession | PR00489 |
No. of Motifs | 7 |
Creation Date | 22-MAR-1996  (UPDATE 28-JUL-1999) |
Title | Frizzled protein signature |
Database References | PRINTS; PR90007 7TM INTERPRO; IPR000539 |
Literature References | 1. VINSON, C.R., CONOVER, S. AND ADLER, P.N.
A Drosophila tissue polarity locus encodes a protein containing seven
potential transmembrane domains.
NATURE 338 263-264 (1989).
2. ADLER, P.N., VINSON, C., PARK, W.J., CONOVER, S. AND KLEIN, L.
Molecular structure of frizzled, a Drosophila tissue polarity gene.
GENETICS 126 401-416 (1990).
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Documentation | The frizzled (fz) locus of Drosophila coordinates the cytoskeletons of
epidermal cells, producing a parallel array of cuticular hairs and bristles
[1,2]. In fz mutants, the orientation of individual hairs with respect both
to their neighbours and to the organism as a whole is altered - in the wild-
type wing, all hairs point towards the distal tip [1]. In the developing
wing, fz has 2 functions: it is required for the proximal-distal
transmission of an intracellular polarity signal; and it is required for
cells to respond to the polarity signal.
Fz produces an mRNA that encodes an integral membrane protein with 7
putative transmembrane (TM) domains. This protein should contain both
extracellular and cytoplasmic domains, which could function in the
transmission and interpretation of polarity information [1].
FRIZZLED is a 7-element fingerprint that provides a signature for frizzled
proteins. The fingerprint was derived from an initial alignment of 5
sequences: the motifs were drawn from the 7 putative TM regions. Two
iterations on OWL27.1 were required to reach convergence, at which point
a true set comprising 12 sequences was identified. A single partial match
was also found, a frizzled protein fragment lacking the last 3 motifs.
An update on SPTR37_9f identified a true set of 25 sequences, and 1
partial match.
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Summary Information | 25 codes involving 7 elements 0 codes involving 6 elements 0 codes involving 5 elements 0 codes involving 4 elements 1 codes involving 3 elements 0 codes involving 2 elements
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Composite Feature Index | 7 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
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True Positives | FRIZ_DROME O00144 O16147 O16190 O42579 O57328 O57329 O60353 O70421 O75084 O93274 P91682 P97698 Q08463 Q08464 Q13467 Q14332 Q61086 Q61088 Q61089 Q61090 Q61091 Q94132 Q94916 Q99835 |
True Positive Partials | Codes involving 3 elements O77438 |
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Sequence Titles | FRIZ_DROME FRIZZLED PROTEIN PRECURSOR - DROSOPHILA MELANOGASTER (FRUIT FLY). O00144 FRIZZLED HOMOLOG - HOMO SAPIENS (HUMAN). O16147 MOM-5 - CAENORHABDITIS ELEGANS. O16190 F27E11.3 PROTEIN - CAENORHABDITIS ELEGANS. O42579 FRIZZLED 3 PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG). O57328 7-TRANSMEMBRANE PROTEIN FRIZZLED-1 - GALLUS GALLUS (CHICKEN). O57329 7-TRANSMEMBRANE PROTEIN FRIZZLED-7 - GALLUS GALLUS (CHICKEN). O60353 FRIZZLED-6 - HOMO SAPIENS (HUMAN). O70421 FRIZZLED-1 - MUS MUSCULUS (MOUSE). O75084 FZE3 - HOMO SAPIENS (HUMAN). O93274 FRIZZLED 8 PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG). P91682 SMOOTHENED PROTEIN PRECURSOR (SEVEN-PASS MEMBRANE PROTEIN) (DSMO) (SMOH) (SMOOTH) - DROSOPHILA MELANOGASTER (FRUIT FLY). P97698 SMOOTHENED HOMOLOG PRECURSOR (SEVEN-PASS MEMBRANE PROTEIN) (SMO) - RATTUS NORVEGICUS (RAT). Q08463 FRIZZLED PROTEIN HOMOLOG 1 (FZ-1) - RATTUS NORVEGICUS (RAT). Q08464 FRIZZLED PROTEIN HOMOLOG 2 PRECURSOR (FZ-2) - RATTUS NORVEGICUS (RAT). Q13467 TRANSMEMBRANE RECEPTOR - HOMO SAPIENS (HUMAN). Q14332 FRIZZLED GENE PRODUCT - HOMO SAPIENS (HUMAN). Q61086 FRIZZLED-3 - MUS MUSCULUS (MOUSE). Q61088 FRIZZLED HOMOLOG 4 (TRANSMEMBRANE RECEPTOR) - MUS MUSCULUS (MOUSE). Q61089 FRIZZLED HOMOLOG 6 (TRANSMEMBRANE RECEPTOR) - MUS MUSCULUS (MOUSE). Q61090 FRIZZLED HOMOLOG 7 (TRANSMEMBRANE RECEPTOR) - MUS MUSCULUS (MOUSE). Q61091 FRIZZLED HOMOLOG 8 (TRANSMEMBRANE RECEPTOR) - MUS MUSCULUS (MOUSE). Q94132 TRANSMEMBRANE RECEPTOR LIN-17 - CAENORHABDITIS ELEGANS. Q94916 DFZ2 - DROSOPHILA MELANOGASTER (FRUIT FLY). Q99835 SMOOTHENED HOMOLOG PRECURSOR (SEVEN-PASS MEMBRANE PROTEIN) (SMO) - HOMO SAPIENS (HUMAN). O77438 EG:34F3.6 PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
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Scan History | OWL27_1 2 100 NSINGLE SPTR37_9f 4 50 NSINGLE
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Initial Motifs | Motif 1 width=23 Element Seqn Id St Int Rpt WILTWSVLCCASTFFTVTTSLVA RATFRZH 252 252 - WILTWSVLCCASTFFTVTTYLVD HUMFRIZ 247 247 - WIGIWSVLCCASTLFTVLTYLVD RATFRZZH 316 316 - WVGSWAAICVATCLFTVLTFLID DROTPP 254 254 - WVGSWAAVCVASCLFTVLTFLID FRIZ_DROME 249 249 - Motif 2 width=23 Element Seqn Id St Int Rpt YPERAIVFLAVCYLVVGCAYVAG DROTPP 282 5 - YPERPIIFLSGCYTAVAVAYIAG RATFRZZH 344 5 - YPERPIIFLSGCYTMVSVAYIAG HUMFRIZ 275 5 - YPERPIIFLSGCYTMVSVAYIAG RATFRZH 280 5 - YPERAIVFLAVCYLVVGCAYVAG FRIZ_DROME 277 5 - Motif 3 width=25 Element Seqn Id St Int Rpt ILFMMLYFFSMASSIWWVILSLTWF HUMFRIZ 329 31 - VLFMALYFCCMAAFAWWSCLAFAWF FRIZ_DROME 339 39 - ILFMMLYFFSMASSIWWVILSLTWF RATFRZZH 398 31 - VLFMALYFCCMAAFAWWSCLAFAWF DROTPP 344 39 - ILFMMLYFFSMASSIWWVILSLTWF RATFRZH 334 31 - Motif 4 width=24 Element Seqn Id St Int Rpt FHLAAWAVPAVKTITILAMGQIDG RATFRZH 377 18 - FHLAAWAVPAVKTITILAMGQIDG HUMFRIZ 372 18 - FHLVAWAVPALQTISVLALAKVEG DROTPP 387 18 - FHLAAWAVPAIKTITILALGQVDG RATFRZZH 441 18 - FHLVAWAVPALQTISVLALAKVEG FRIZ_DROME 382 18 - Motif 5 width=23 Element Seqn Id St Int Rpt ILPLCIYLSIGALFLLAGFISLF DROTPP 432 21 - LAPLFVYLFIGTSFLLAGFVSLF RATFRZZH 486 21 - LAPLFVYLFIGTSFLLAGFVSLF HUMFRIZ 417 21 - LAPLFVYLFIGTSFLLAGFVSLF RATFRZH 422 21 - ILPLCIYLSIGALFLLAGFISLF FRIZ_DROME 427 21 - Motif 6 width=22 Element Seqn Id St Int Rpt LMLRIGFFSGLFILPGLGLLGC DROTPP 473 18 - LMVRIGVFSVLYTVPATIVIAC RATFRZZH 527 18 - LMVRIGVFSVLYTVPATIVIAC RATFRZH 463 18 - LMLRIGFFSGLFILPAVGLLGC FRIZ_DROME 468 18 - LMVRIGVFSVLYTVPATIVIAC HUMFRIZ 458 18 - Motif 7 width=21 Element Seqn Id St Int Rpt VFMIKYLMTLIVGITSGFWIW RATFRZZH 596 47 - VYMIKYLMTLIVGITSGFWIW HUMFRIZ 520 40 - VYMIKYLMTLIVGITSGFWIW RATFRZH 525 40 - IFMVKYLCSMLVGVTSSVWLY FRIZ_DROME 533 43 - IYMVKYLCSMLVGVTSSVWLY DROTPP 538 43 -
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Final Motifs | Motif 1 width=23 Element Seqn Id St Int Rpt WIGIWSVLCCASTLFTVLTYLVD Q08463 316 316 - WIGIWSVLCCASTLFTVLTYLVD O57328 271 271 - WVGVWSVLCCASTLFTVLTYLVD O57329 250 250 - WILTWSVLCCASTFFTVTTYLVD Q14332 247 247 - WVGVWSVLSCASTLFTVLTYLVD Q61090 254 254 - WILTWSVLCCASTFFTVTTSLVA Q08464 252 252 - WVGVWSVLCCASTLFTVLTYLVD O75084 256 256 - WIGLWSVLCFASTFATVSTFLID O93274 239 239 - WIGIWSVLCCASTLFTVLTYLVD O70421 317 317 - WIGLWSVLCFVSTFATVSTFLID Q61091 277 277 - WIGLWSVLCFISTSTTVATFLID Q13467 238 238 - WIALWSGLCFCSTLMTLTTFIID Q94916 320 320 - WMAVWASLCFISTTFTVLTFLID Q61088 222 222 - WMAVWSALCFFSTAFTVLTFLLE O00144 234 234 - FIGLISIICLSATLFTFLTFLID Q61086 205 205 - FIGTVSIFCLCATLFTFLTFLID O60353 201 201 - FIGVISIVCLSATLFTFLTFLID O42579 204 204 - FIGIVSIFCLCATLFTFLTFLID Q61089 201 201 - WVGSWAAVCVASCLFTVLTFLID FRIZ_DROME 249 249 - WMAFWSITCCVLASFTFLTFLIE O16190 197 197 - WTAAWSVACFVCSLFTLVTFLVD O16147 230 230 - YIAAFGAVTGLCTLFTLATFVAD Q99835 233 233 - YIAAFGAVTGLCTLFTLATFVAD P97698 237 237 - LIGWAGSICLLSNLFVVSTFFID P91682 258 258 - WSIWFAAANAGVALFSFLTFAID Q94132 207 207 - Motif 2 width=23 Element Seqn Id St Int Rpt YPERPIIFLSGCYTAVAVAYIAG Q08463 344 5 - YPERPIIFLSGCYTAVAVAYIAG O57328 299 5 - YPERPIIFLSGCYFMVAVAYAAG O57329 278 5 - YPERPIIFLSGCYTMVSVAYIAG Q14332 275 5 - YPERPIIFLSGCYFMVAVAHVAG Q61090 282 5 - YPERPIIFLSGCYTMVSVAYIAG Q08464 280 5 - YPERPIIFLSGCYFMVAVAHVAG O75084 284 5 - YPERPIIFLSACYLLVSTGYLIR O93274 267 5 - YPERPIISLSGCYTAVAVAYIAG O70421 345 5 - YPERPIIFLSACYLFVSVGYLVR Q61091 305 5 - YPERPIIFLSACYLCVSLGFLVR Q13467 266 5 - YPERPIVFLSACYFMVAVGYLSR Q94916 348 5 - YPERPIIFLSMCYNIYSIAYIVR Q61088 250 5 - YPERPIIFLSMCYNVYSLAFLIR O00144 262 5 - YPERPIIFYAVCYMMVSLIFFIG Q61086 233 5 - YPERPIIYYSVCYSIVSLMYFIG O60353 229 5 - YPERPIIFYAVCYMMVSLIFFIG O42579 232 5 - YPERPIIYYSVCYSIVSLMYFVG Q61089 229 5 - YPERAIVFLAVCYLVVGCAYVAG FRIZ_DROME 277 5 - YPERPIFMLAFCQLMVAVGFMIR O16190 225 5 - YPVRPILYLAFCYLAISTVYMIG O16147 258 5 - YPAVILFYVNACFFVGSIGWLAQ Q99835 262 6 - YPAVILFYVNACFFVGSIGWLAQ P97698 266 6 - YPAVIVFYINLCFLIACVGWLLQ P91682 287 6 - FPERCVFYLSLCIFISSLPYLTP Q94132 235 5 - Motif 3 width=25 Element Seqn Id St Int Rpt ILFMMLYFFSMASSIWWVILSLTWF Q08463 398 31 - ILFMMLYFFGMASSIWWVILSLTWF O57328 353 31 - ILFMILYFFGMASSIWWVILSLTWF O57329 332 31 - ILFMMLYFFSMASSIWWVILSLTWF Q14332 329 31 - ILFMVLYFFGMASSIWWVILSLTWF Q61090 336 31 - ILFMMLYFFSMASSIWWVILSLTWF Q08464 334 31 - ILFMVLYFFGMASSIWWVILSLTWF O75084 338 31 - LVFLLIYFFGMASSIWWVILSLTWF O93274 322 32 - ILFMMLYFFSMASSIWWVILSLTWF O70421 399 31 - VVFLLVYFFGMASSIWWVILSLTWF Q61091 396 68 - IVFLLVYFFGMASSIWWVILSLTWF Q13467 317 28 - LVFLLTYFFGMASSIWWVILTFTWF Q94916 397 26 - IIFLLMYFFGMASSIWWVILTLTWF Q61088 304 31 - LVFLLLYYFGMASSLWWVVLTLTWF O00144 315 30 - MLFMVLYFFTMAGSVWWVILTITWF Q61086 288 32 - VLFMLLYFFTMAGTVWWVILTITWF O60353 284 32 - MLFMVLYFFTMAGSVWWVILTITWF O42579 287 32 - VVFMFLYFFTMAGTVWWVILTITWF Q61089 284 32 - VLFMALYFCCMAAFAWWSCLAFAWF FRIZ_DROME 339 39 - VVFLLTYFFGMAASVWWVILSLTWV O16190 275 27 - ALAVVHYFFFMSSCAWWLVLCLAWF O16147 311 30 - IIFVIVYYALMAGVVWFVVLTYAWH Q99835 316 31 - IIFVIVYYALMAGVVWFVVLTYAWH P97698 320 31 - VIFVLVYYFLTAGMVWFVFLTYAWH P91682 341 31 - ASFLLNYFFSTAAALWWLMFSFTLY Q94132 289 31 - Motif 4 width=24 Element Seqn Id St Int Rpt FHLAAWAVPAIKTITILALGQVDG Q08463 441 18 - FHLAAWAVPAIKTITILALGQVDG O57328 396 18 - FHLAAWAVPAVKTITILAMGQVDG O57329 375 18 - FHLAAWAVPAVKTITILAMGQIDG Q14332 372 18 - FHLAAWAVPAVKTITILAMGQVDG Q61090 379 18 - FHLAAWAVPAVKTITILAMGQIDG Q08464 377 18 - FHLAAWAVPAVKTITILAMGQVDG O75084 381 18 - FHLAAWLVPSIKSIAVLALSSVDG O93274 365 18 - FHLAAWAVPAIKTITILALGQVDG O70421 442 18 - FHLAAWLVPSVKSIAVLALSSVDG Q61091 439 18 - FHLAAWLIPSVKSITALALSSVDG Q13467 360 18 - FHLAAWLIPTVQSVAVLLLSAVDG Q94916 440 18 - FHIAAWAIPAVKTIVILIMRLVDA Q61088 347 18 - FHMAAWGLPALKTIVILTLRKVAG O00144 358 18 - FHASAWGIPGTLTIILLAMNKIEG Q61086 331 18 - FHAVAWGTPGFLTVMLLALNKVEG O60353 327 18 - FHASAWGIPGTLTIILLAMNKIEG O42579 330 18 - FHAVAWGAPGFLTVMLLAMNKVEG Q61089 327 18 - FHLVAWAVPALQTISVLALAKVEG FRIZ_DROME 382 18 - FHVVGWCLPAIQTVLVIVFNAIDG O16190 318 18 - FHAMCWGVPAVLSVTVLVTNSVDG O16147 354 18 - FHLLTWSLPFVLTVAILAVAQVDG Q99835 360 19 - FHLLTWSLPFVLTVAILAVAQVDG P97698 364 19 - FHLVAWSLPLVLTITTMAFSEVDG P91682 383 17 - VHFVAWGLSSLATIIVLIFNKVDA Q94132 332 18 - Motif 5 width=23 Element Seqn Id St Int Rpt LAPLFVYLFIGTSFLLAGFVSLF Q08463 486 21 - LAPLFVYLFIGTSFLLAGFVSLF O57328 441 21 - LAPLFVYLFIGTSFLLAGFVSLF O57329 420 21 - LAPLFVYLFIGTSFLLAGFVSLF Q14332 417 21 - LAPLFVYLFIGTSFLLAGFVSLF Q61090 424 21 - LAPLFVYLFIGTSFLLAGFVSLF Q08464 422 21 - LAPLFVYFFIGTSFLLAGFVSFF O75084 426 21 - LAPLVIYLFIGSMFLLAGFVSLF O93274 410 21 - LAPLFVYLFIGTSFLLAGFVSLF O70421 487 21 - LAPLVIYLFIGTMFLLAGFVSLF Q61091 484 21 - LGPLVLYLLVGTLFLLAGFVSLF Q13467 405 21 - LAPLFVYLVIGTTFLMAGFVSLF Q94916 485 21 - VAPLFTYLVIGTLFIAAGLVALF Q61088 392 21 - LVPLSGYLVLGSSFLLTGFVALF O00144 403 21 - LAPLCLYVVVGVSLLLAGIISLN Q61086 376 21 - LLPLCLCVFVGLSLLLAGIISLN O60353 372 21 - LAPLCLDVVVGVSLLLAGIISLN O42579 375 21 - LLPLCLCVFVGLSLLLAGIISLN Q61089 372 21 - ILPLCIYLSIGALFLLAGFISLF FRIZ_DROME 427 21 - LFPLLVYFIVGVLFLVIGFCNLW O16190 363 21 - FTPIVVSLALGAVLLVCGIWSMI O16147 399 21 - LAPIGLVLIVGGYFLIRGVMTLF Q99835 405 21 - LAPIGLVLIVGGYFLIRGVMTLF P97698 409 21 - LGPLCGVILIGGYFITRGMVMLF P91682 428 21 - IVPRTICIVIGTCFIVGGFASMC Q94132 377 21 - Motif 6 width=22 Element Seqn Id St Int Rpt LMVRIGVFSVLYTVPATIVIAC Q08463 527 18 - LMVRIGIFSVLYTVPATIVIAC O57328 482 18 - LMVRIGVFSVLYTVPATIVVAC O57329 461 18 - LMVRIGVFSVLYTVPATIVIAC Q14332 458 18 - LMVRIGVFSVLYTVPATIVLAC Q61090 465 18 - LMVRIGVFSVLYTVPATIVIAC Q08464 463 18 - LMVRIGVFSVLYTVPATIVLAC O75084 467 18 - LMIRIGIFSVLYTVPATIVVAC O93274 451 18 - LMVRIGVFSVLYTVPATIVIAC O70421 528 18 - LMIRLGLFTVLYTVPAAVVVAC Q61091 527 20 - LMIRIGIFTLLYTVPASIVVAC Q13467 446 18 - LMIRIGIFSVLYTVPATIVIGC Q94916 531 23 - LMVKIGVFSVLYTVPATCVIAC Q61088 433 18 - LMVKIGVFSILYTVPATCVIVC O00144 444 18 - FMIRIGVFSILYLVPLLVVIGC Q61086 417 18 - FMIRIGVFSGLYLVPLVTLLGC O60353 413 18 - FMIRIGVFSILYLVPLLVVIGC O42579 416 18 - FMIRIGVFSGLYLVPLVTLLGC Q61089 413 18 - LMLRIGFFSGLFILPAVGLLGC FRIZ_DROME 468 18 - LMSKIGIFSLLYTIPSLLIICV O16190 407 21 - LMLRIGAFAIMYSLPTAMNAAI O16147 444 22 - TMLRLGIFGFLAFGFVLITFSC Q99835 448 20 - TMLRLGIFGFLAFGFVLITFSC P97698 452 20 - IIMRMGVCALLTLVFILVAIAC P91682 471 20 - LMVKMGFFCALFILPNVIELVC Q94132 418 18 - Motif 7 width=21 Element Seqn Id St Int Rpt VFMIKYLMTLIVGITSGFWIW Q08463 596 47 - VFMIKYLMTLIVGITSGFWIW O57328 547 43 - VFMIKYLMTMIVGITTGFWIW O57329 522 39 - VYMIKYLMTLIVGITSGFWIW Q14332 520 40 - VFMIKYLMTMIVGITTGFWIW Q61090 527 40 - VYMIKYLMTLIVGITSGFWIW Q08464 525 40 - VFMIKCLMTMIVGITTGFWIW O75084 529 40 - VFMLKYFMCLVVGITSGVWIW O93274 506 33 - VFMIKYLMTLNSWRKFYTRLT O70421 597 47 - VFMLKYFMCLVVGITSGVWVW Q61091 583 34 - VLMLKYFMCLVVGITSGVWIW Q13467 502 34 - VLMLKYFMALAVGITSGVWIW Q94916 585 32 - VEMLKIFMSLLVGITSGMWIW Q61088 476 21 - VFMLKIFMSLVVGITSGVWVW O00144 509 43 - LFLMKYLMALIVGIPSIFWVG Q61086 479 40 - LFMIKYLMTLIVGISAVFWVG O60353 475 40 - LFLMKYLMLLVVGIPSVFWVG O42579 478 40 - LFMIKYLMTLIVGISAVFWVG Q61089 475 40 - IFMVKYLCSMLVGVTSSVWLY FRIZ_DROME 533 43 - ISLIKTCCMCILGWTSGFWVC O16190 526 97 - VFLLKYVSQLVVGITCAIWVV O16147 516 50 - VEKINLFAMFGTGIAMSTWVW Q99835 517 47 - VEKINLFAMFGTGIAMSTWVW P97698 521 47 - VLQLHLLCLFSSGIVMSTWCW P91682 535 42 - IYMTAVISSLATGFSCLMWVL Q94132 474 34 -
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