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PR00475

Identifier
HEXOKINASE  [View Relations]  [View Alignment]  
Accession
PR00475
No. of Motifs
7
Creation Date
19-FEB-1996  (UPDATE 07-JUN-1999)
Title
Hexokinase family signature
Database References

PROSITE; PS00378 HEXOKINASES
BLOCKS; BL00378
PFAM; PF00349 hexokinase
INTERPRO; IPR001312
PDB; 1HKG
SCOP; 1HKG
Literature References
1. ALBIG, W. AND ENTIAN, K.D.
Structure of yeast glucokinase, a strongly diverged specific aldo-
hexose-phosphorylating isoenzyme.
GENE 73 141-152 (1988).
 
2. GRIFFIN, L.D., GELB, B.D., WHEELER, D.A., DAVISON, D., ADAMS, V.
AND MCCABE, E.R.
Mammalian hexokinase 1: evolutionary conservation and structure to 
function analysis.
GENOMICS 11 1014-1024 (1991). 
 
3. MAGNANI, M., BIANCHI, M., CASABIANCI, A., STOCCHI, V., DANIELE, A., 
ALTRUDA, F., FERRONE, M. AND SILENGO, L.
A recombinant human 'mini'-hexokinase is catalytically active and
regulated by hexose-6-phosphates.
BIOCHEM.J. 285 193-199 (1992).

Documentation
Hexokinase is an important enzyme that catalyses the ATP-dependent
conversion of aldo- and keto-hexose sugars to the hexose-6-phosphate [1,2].
The enzyme can catalyse this reaction on glucose, fructose, sorbitol and 
glucosamine, and as such is the first step in a number of metabolic
pathways [1]. 
 
There are 3 isozymes of hexokinase in yeast (PI, PII and glucokinase):
isozymes PI and PII phosphorylate both aldo- and keto-sugars; glucokinase
is specific for aldo-hexoses [1]. All 3 isozymes contain a single copy of
the hexokinase domain [1,2]. Vertebrates contain 4 hexokinase isozymes 
(designated I to IV [2]): types I to III contain 2 repeats of the hexokinase
domain, and are thought to be derived by gene duplication of a yeast
hexokinase that is insensitve to product inhibition [3]. The N-terminal
unit of types I to III is the regulatory- and the C-terminal unit the
catalytic-region [2]. It is believed that a mutation in the N-terminal
ATP-binding domain has caused the loss of the ability to dephosphorylate
ATP, resulting in loss of catalytic activity and the subsequent change to
a regulatory role [2]. However, some studies have suggested the C-terminal
catalytic region may also contain a regulatory site [3]. Type IV hexokinase
contains only one hexokinase domain, and is sometimes incorrectly referred
to as glucokinase.
 
Structural studies of yeast hexokinase reveal a well-defined catalytic
pocket that binds ATP and hexose, allowing easy transfer of the phosphate
from ATP to the sugar.
 
HEXOKINASE is a 7-element fingerprint that provides a signature for the 
hexokinase family. The fingerprint was derived from an initial alignment
of 7 sequences: the motifs were drawn from conserved regions spanning
virtually the full alignment length, motif 1 encoding the putative ATP-
binding domain, and motif 2 including the sugar-binding region encoded by
PROSITE pattern HEXOKINASES (PS00378). All motifs, except motif 6, contain
amino acids that project into or near the ATP/sugar-binding pocket. Two 
iterations on OWL27.0 were required to reach convergence, at which point
a true set comprising 36 sequences was identified.
 
An update on SPTR37_9f identified a true set of 43 sequences, and 1
partial match.
Summary Information
  43 codes involving  7 elements
0 codes involving 6 elements
0 codes involving 5 elements
1 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
743434343434343
60000000
50000000
41001110
30000000
20000000
1234567
True Positives
HXK1_BOVIN    HXK1_HUMAN    HXK1_MOUSE    HXK1_RAT      
HXK1_SCHPO HXK2_HUMAN HXK2_MOUSE HXK2_RAT
HXK2_SCHPO HXK3_HUMAN HXK3_RAT HXKA_YEAST
HXKB_YEAST HXKG_ASPNG HXKG_YEAST HXKH_HUMAN
HXKH_MOUSE HXKH_RAT HXKP_HUMAN HXKP_MOUSE
HXKP_RAT HXK_ARATH HXK_DEBOC HXK_KLULA
HXK_PLAFA HXK_SCHMA O09487 O09488
O43443 O43444 O54892 O64390
O74996 P93834 Q04409 Q05838
Q19440 Q27647 Q27648 Q42535
Q64476 Q64596 Q91753
True Positive Partials
Codes involving 4 elements
O83518
Sequence Titles
HXK1_BOVIN  HEXOKINASE, TYPE I (EC 2.7.1.1) (HK I) (BRAIN FORM HEXOKINASE) - BOS TAURUS (BOVINE). 
HXK1_HUMAN HEXOKINASE, TYPE I (EC 2.7.1.1) (HK I) (BRAIN FORM HEXOKINASE) - HOMO SAPIENS (HUMAN).
HXK1_MOUSE HEXOKINASE, TYPE I (EC 2.7.1.1) (HK I) (HEXOKINASE, TUMOR ISOZYME) - MUS MUSCULUS (MOUSE).
HXK1_RAT HEXOKINASE, TYPE I (EC 2.7.1.1) (HK I) (BRAIN FORM HEXOKINASE) - RATTUS NORVEGICUS (RAT).
HXK1_SCHPO HEXOKINASE 1 (EC 2.7.1.1) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
HXK2_HUMAN HEXOKINASE, TYPE II (EC 2.7.1.1) (HK II) - HOMO SAPIENS (HUMAN).
HXK2_MOUSE HEXOKINASE TYPE II (EC 2.7.1.1) (HK II) - MUS MUSCULUS (MOUSE).
HXK2_RAT HEXOKINASE TYPE II (EC 2.7.1.1) (HK II) - RATTUS NORVEGICUS (RAT).
HXK2_SCHPO HEXOKINASE 2 (EC 2.7.1.1) - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
HXK3_HUMAN HEXOKINASE TYPE III (EC 2.7.1.1) (HK III) - HOMO SAPIENS (HUMAN).
HXK3_RAT HEXOKINASE TYPE III (EC 2.7.1.1) (HK III) - RATTUS NORVEGICUS (RAT).
HXKA_YEAST HEXOKINASE A (EC 2.7.1.1) (HEXOKINASE PI) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXKB_YEAST HEXOKINASE B (EC 2.7.1.1) (HEXOKINASE PII) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXKG_ASPNG GLUCOKINASE (EC 2.7.1.2) (GLUCOSE KINASE) (GLK) - ASPERGILLUS NIGER.
HXKG_YEAST GLUCOKINASE (EC 2.7.1.2) (GLUCOSE KINASE) (GLK) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
HXKH_HUMAN HEXOKINASE D, LIVER ISOZYMES (EC 2.7.1.1) (HEXOKINASE TYPE IV) (HK4) (GLUCOKINASE) - HOMO SAPIENS (HUMAN).
HXKH_MOUSE HEXOKINASE D, HEPATIC ISOZYME (EC 2.7.1.1) (HEXOKINASE TYPE IV) (HK4) (GLUCOKINASE) - MUS MUSCULUS (MOUSE).
HXKH_RAT HEXOKINASE D, HEPATIC ISOZYME (EC 2.7.1.1) (HEXOKINASE TYPE IV) (HK4) (GLUCOKINASE) - RATTUS NORVEGICUS (RAT).
HXKP_HUMAN HEXOKINASE D, PANCREATIC ISOZYME (EC 2.7.1.1) (HEXOKINASE TYPE IV) (HK4) (GLUCOKINASE) - HOMO SAPIENS (HUMAN).
HXKP_MOUSE HEXOKINASE D, PANCREATIC ISOZYME (EC 2.7.1.1) (HEXOKINASE TYPE IV) (HK4) (GLUCOKINASE) - MUS MUSCULUS (MOUSE).
HXKP_RAT HEXOKINASE D, PANCREATIC ISOZYMES (EC 2.7.1.1) (HEXOKINASE TYPE IV) (HK4) (GLUCOKINASE) - RATTUS NORVEGICUS (RAT).
HXK_ARATH HEXOKINASE (EC 2.7.1.1) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
HXK_DEBOC HEXOKINASE (EC 2.7.1.1) - DEBARYOMYCES OCCIDENTALIS (YEAST) (SCHWANNIOMYCES OCCIDENTALIS).
HXK_KLULA HEXOKINASE (EC 2.7.1.1) - KLUYVEROMYCES LACTIS (YEAST).
HXK_PLAFA HEXOKINASE (EC 2.7.1.1) - PLASMODIUM FALCIPARUM.
HXK_SCHMA HEXOKINASE (EC 2.7.1.1) - SCHISTOSOMA MANSONI (BLOOD FLUKE).
O09487 HEXOKINASE (EC 2.7.1.1) (GLUCOKINASE) (HEXOKINASE TYPE IV) - ENTAMOEBA DISPAR.
O09488 HEXOKINASE (EC 2.7.1.1) (GLUCOKINASE) (HEXOKINASE TYPE IV) - ENTAMOEBA DISPAR.
O43443 HEXOKINASE I (EC 2.7.7.1) (NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE) (NAD(+) PYROPHOSPHORYLASE) - HOMO SAPIENS (HUMAN).
O43444 HEXOKINASE I (EC 2.7.7.1) (NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE) (NAD(+) PYROPHOSPHORYLASE) - HOMO SAPIENS (HUMAN).
O54892 MUTANT TYPE II HEXOKINASE - RATTUS NORVEGICUS (RAT).
O64390 HEXOKINASE - SOLANUM TUBEROSUM (POTATO).
O74996 HEXOKINASE - YARROWIA LIPOLYTICA (CANDIDA LIPOLYTICA).
P93834 HEXOKINASE 2 (EC 2.7.1.1) (GLUCOKINASE) (HEXOKINASE TYPE IV) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
Q04409 D9719.21P - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Q05838 HEXOKINASE PI (HXK2) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Q19440 F14B4.2 PROTEIN - CAENORHABDITIS ELEGANS.
Q27647 HEXOKINASE (EC 2.7.1.1) (GLUCOKINASE) (HEXOKINASE TYPE IV) - ENTAMOEBA HISTOLYTICA.
Q27648 HEXOKINASE (EC 2.7.1.1) (GLUCOKINASE) (HEXOKINASE TYPE IV) - ENTAMOEBA HISTOLYTICA.
Q42535 HEXOKINASE 1 (EC 2.7.1.1) (GLUCOKINASE) (HEXOKINASE TYPE IV) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
Q64476 HEXOKINASE (EC 2.7.1.1) - MUS MUSCULUS (MOUSE).
Q64596 RAT GLUCOKINASE, ALTERNATIVELY SPLICED GK3 (EC 2.7.1.1) (HEXOKINASE) (HEXOKINASE TYPE IV) (HEXOKINASE TYPE 4) - RATTUS NORVEGICUS (RAT).
Q91753 GLUCOKINASE - XENOPUS LAEVIS (AFRICAN CLAWED FROG).

O83518 HEXOKINASE (HXK) - TREPONEMA PALLIDUM.
Scan History
OWL27_0    2  100  NSINGLE    
SPTR37_9f 2 64 NSINGLE
Initial Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
LALDLGGTNFRVLLVKI HXK1_BOVIN 529 529 -
LSLDLGGTNFRVMLVKV HXKP_HUMAN 75 75 -
LAIDLGGTNLRVVLVKL HXKA_YEAST 83 83 -
LALDLGGTNFRVLLVKI HXK1_MOUSE 529 529 -
LALDLGGTNLRVVLVKL HXK_KLULA 83 83 -
LAADLGGTNFRICSVNL HXKG_YEAST 82 82 -
YAIDFGGTNFRAVRASL HXK_PLAFA 99 99 -

Motif 2 width=26
Element Seqn Id St Int Rpt
LGFTFSYPVDQTSLNSGTLIRWTKGF HXKG_YEAST 159 60 -
LGFTFSFPCKQTSLDCGILITWTKGF HXK1_MOUSE 598 52 -
LGFTFSFPCQQTSLDAGILITWTKGF HXK1_BOVIN 598 52 -
LGFTFSFPVRHEDIDKGILLNWTKGF HXKP_HUMAN 146 54 -
LGFTFSYPASQNKINEGILQRWTKGF HXKA_YEAST 153 53 -
LGFTFSYPASQKKINSGVLQRWTKGF HXK_KLULA 152 52 -
VGFTFSFPCTSPSINCSILIDWTKGF HXK_PLAFA 178 62 -

Motif 3 width=17
Element Seqn Id St Int Rpt
VVALTNDTVGTYLSHCY HXKG_YEAST 212 27 -
VVAVVNDTVGTMMTCAY HXK1_MOUSE 651 27 -
VVAVVNDTVGTMMTCAY HXK1_BOVIN 651 27 -
VVAMVNDTVATMISCYY HXKP_HUMAN 199 27 -
IVALINDTVGTLIASYY HXKA_YEAST 205 26 -
VVRLINDTTGTLVASLY HXK_KLULA 204 26 -
VCCVLNDAVGTLMSCAY HXK_PLAFA 235 31 -

Motif 4 width=15
Element Seqn Id St Int Rpt
VGMIVGTGCNACYME HXKP_HUMAN 222 6 -
IGLIVGTGSNACYME HXK1_MOUSE 674 6 -
VGLIVGTGSNACYME HXK1_BOVIN 674 6 -
MGVIFGTGVNGAFYD HXKA_YEAST 228 6 -
MGIIIGTGVNGAYYD HXK_KLULA 227 6 -
IGCIFGTGTNGCYME HXKG_YEAST 246 17 -
IGIILGTGSNGCYYE HXK_PLAFA 262 10 -

Motif 5 width=23
Element Seqn Id St Int Rpt
QLFEKMISGAYLGEIVRRFMVNV HXK_PLAFA 319 42 -
QRFEKMISGMYLGEIVRNILIDF HXK1_MOUSE 739 50 -
QRFENMISGIYLGEIVRNILIDF HXK1_BOVIN 739 50 -
QLYEKLIGGKYMGELVRLVLLRL HXKP_HUMAN 287 50 -
QAFEKMTSGYYLGELLRLVLLEL HXKA_YEAST 299 56 -
QAFEKMTSGYYLGEIMRLVLLDL HXK_KLULA 298 56 -
HLFEKRVSGMFLGEVLRNILVDL HXKG_YEAST 320 59 -

Motif 6 width=23
Element Seqn Id St Int Rpt
IQKLVRAISRRSAYLAAVPLAAI HXKG_YEAST 407 64 -
VKTVCGVVSKRAAQLCGAGMAAV HXK1_MOUSE 819 57 -
VKTVCGVVSKRAAQLCGAGMAAV HXK1_BOVIN 819 57 -
VRRACESVSTRAAHMCSAGLAGV HXKP_HUMAN 367 57 -
IRRLCELIGTRAARLAVCGIAAI HXKA_YEAST 381 59 -
IRKLAELVGTRAARLTVCGVSAI HXK_KLULA 380 59 -
LRKICEAVYNRSAALARGTIAAI HXK_PLAFA 395 53 -

Motif 7 width=17
Element Seqn Id St Int Rpt
KIAKDGSGVGAALCALV HXKG_YEAST 483 53 -
LLSEDGSGKGAALITAV HXK1_BOVIN 891 49 -
IESEEGSGRGAALVSAV HXKP_HUMAN 439 49 -
LLSEDGSGKGAALITAV HXK1_MOUSE 891 49 -
VPAEDGSGAGAAVIAAL HXKA_YEAST 453 49 -
VAAEDGSGVGAAIIACL HXK_KLULA 453 50 -
IPADDGSGKGAAITAAV HXK_PLAFA 466 48 -
Final Motifs
Motif 1  width=17
Element Seqn Id St Int Rpt
LALDLGGTNFRVLLVKI O43444 529 529 -
LALDLGGTNFRVLLVKI O43443 528 528 -
LALDLGGTNFRVLLVKI HXK1_MOUSE 529 529 -
LALDLGGTNFRVLLVKI Q64476 556 556 -
LALDLGGTNFRVLLVKI HXK1_RAT 530 530 -
LALDLGGTNFRVLLVKI HXK1_BOVIN 529 529 -
LALDLGGTNFRVLLVRV HXK2_MOUSE 529 529 -
LALDLGGTNFRVLLVRV O54892 529 529 -
LALDLGGTNFRVLLVRV HXK2_RAT 529 529 -
LALDLGGTNFRVLLVRV HXK3_HUMAN 539 539 -
LALDLGGTNFRVLLVRV HXK2_HUMAN 529 529 -
LALDLGGTNFRVLLVRV HXK3_RAT 539 539 -
LALDLGGTNFRVMLVKV Q91753 68 68 -
LSLDLGGTNFRVMLVKV HXKH_RAT 75 75 -
LSLDLGGTNFRVMLVKV Q64596 108 108 -
LSLDLGGTNFRVMLVKV HXKP_RAT 75 75 -
LSLDLGGTNFRVMLVKV HXKH_MOUSE 75 75 -
LSLDLGGTNFRVMLVKV HXKP_MOUSE 75 75 -
LSLDLGGTNFRVMLVKV HXKH_HUMAN 76 76 -
LSLDLGGTNFRVMLVKV HXKP_HUMAN 75 75 -
LALDLGGTNFRVLHIKL Q19440 97 97 -
LALDLGGTNYRVLSVTL HXK_SCHMA 71 71 -
LAIDLGGTNLRVVLVKL HXKB_YEAST 83 83 -
LAIDLGGTNLRVVLVKL Q05838 83 83 -
LALDLGGTNFRVLLVKI HXK1_HUMAN 529 529 -
LAIDLGGTNLRVVLVKL HXKA_YEAST 83 83 -
YALDLGGTNFRVMRVLL P93834 98 98 -
YALDLGGTNFRVMRVLL HXK_ARATH 37 37 -
YALDLGGTNFRVMRVLL Q42535 98 98 -
LAIDLGGTNLRVVLVKL HXK_DEBOC 83 83 -
LAVDLGGTNFRVCSIDL HXKG_ASPNG 65 65 -
LALDLGGTNLRVVLVKL HXK_KLULA 83 83 -
LALDMGGTNLRVVKVTL O74996 83 83 -
LAADLGGTHFRVCSVTL Q04409 82 82 -
LAADLGGTNFRICSVNL HXKG_YEAST 82 82 -
LALDLGGTNLRVCAVEV HXK1_SCHPO 87 87 -
YALDLGGTNFRVLRVQL O64390 98 98 -
MGIDVGGTNLRVLLLEI O09487 56 56 -
MGIDVGGTNLRVLLLEI Q27647 56 56 -
YAIDFGGTNFRAVRASL HXK_PLAFA 99 99 -
MGIDVGGTNLRVLLLEI O09488 56 56 -
MGIDVGGTNLRVLLLEI Q27648 56 56 -
LALDFGGTNLRVCWIQL HXK2_SCHPO 65 65 -

Motif 2 width=26
Element Seqn Id St Int Rpt
LGFHLLIPSNADFNNSGTIMRWTKGF O64390 172 57 -
LGFTFSFPCQQTSLDAGILITWTKGF HXK1_HUMAN 598 52 -
LGFTFSFPCQQTSLDAGILITWTKGF O43444 598 52 -
LGFTFSFPCQQTSLDAGILITWTKGF O43443 597 52 -
LGFTFSFPCKQTSLDCGILITWTKGF HXK1_MOUSE 598 52 -
LGFTFSFPCKQTSLDCGILITWTKGF Q64476 625 52 -
LGFTFSFPCHQTNLDCGILISWTKGF HXK1_RAT 599 52 -
LGFTFSFPCQQTSLDAGILITWTKGF HXK1_BOVIN 598 52 -
LGFTFSFPCQQNSLDQSILLKWTKGF HXK2_MOUSE 598 52 -
LGFTFSFPCQQNSLDQSILLKWTKGF O54892 598 52 -
LGFTFSFPCQQNSLDQSILLKWTKGF HXK2_RAT 598 52 -
LGFTFSFPCRQLGLDQGILLNWTKGF HXK3_HUMAN 604 48 -
LGFTFSFPCQQNSLDESILLKWTKGF HXK2_HUMAN 598 52 -
LGFTFSFPCKQLGLDQGILLNWTKGF HXK3_RAT 605 49 -
LGFTFSFPVRHEDIDKGILLNWTKGF Q91753 139 54 -
LGFTFSFPVRHEDLDKGILLNWTKGF HXKH_RAT 146 54 -
LGFTFSFPVRHEDLDKGILLNWTKGF Q64596 179 54 -
LGFTFSFPVRHEDLDKGILLNWTKGF HXKP_RAT 146 54 -
LGFTFSFPVRHEDIDKGILLNWTKGF HXKH_MOUSE 146 54 -
LGFTFSFPVRHEDIDKGILLNWTKGF HXKP_MOUSE 146 54 -
LGFTFSFPVRHEDIDKGILLNWTKGF HXKH_HUMAN 147 54 -
LGFTFSFPVRHEDIDKGILLNWTKGF HXKP_HUMAN 146 54 -
LGFTFSFPCEQEGLTKGKLVTWTKGF Q19440 164 50 -
LGFTFSFPCVQKGLTHATLVRWTKGF HXK_SCHMA 139 51 -
LGFTFSFPASQNKINEGILQRWTKGF HXKB_YEAST 153 53 -
LGFTFSFPASQNKINEGILQRWTKGF Q05838 153 53 -
LGFTFSYPASQNKINEGILQRWTKGF HXKA_YEAST 153 53 -
LGFTFSFPVKQLSLSSGTLINWTKGF P93834 172 57 -
LGFTFSFPVKQTSLSSGSLIKWTKGF HXK_ARATH 111 57 -
LGFTFSFPVKQTSLSSGSLIKWTKGF Q42535 172 57 -
LGFTFSYPASQGSINEGYLQRWTKGF HXK_DEBOC 152 52 -
LGFTFSFPVRQLGINKGTLIRWTKGF HXKG_ASPNG 150 68 -
LGFTFSYPASQKKINSGVLQRWTKGF HXK_KLULA 152 52 -
LGFTFSYPCSQPAVNRGVLQRWTKGF O74996 189 89 -
MGFTFSYPVDQTSLSSGTLIRWTKSF Q04409 160 61 -
LGFTFSYPVDQTSLNSGTLIRWTKGF HXKG_YEAST 159 60 -
IGFTFSYPCVQRSINDASLVAWTKGF HXK1_SCHPO 155 51 -
AGLTFSFAVEQIAIDKGIQQSWSKGW O09487 122 49 -
AGLTFSFAVEQIAIDKGIQQSWSKGW Q27647 122 49 -
VGFTFSFPCTSPSINCSILIDWTKGF HXK_PLAFA 178 62 -
AGLTFSFAVEQIAIDKGIQQSWSKGW O09488 122 49 -
AGLTFSFAVEQIAIDKGIQQSWSKGW Q27648 122 49 -
MGFTFSYPANQVSITESYLLRWTKGL HXK2_SCHPO 139 57 -

Motif 3 width=17
Element Seqn Id St Int Rpt
IVAFINDTVGTFANLAY Q27648 175 27 -
VVAVVNDTVGTMMTCAY HXK1_HUMAN 651 27 -
VVAVVNDTVGTMMTCAY O43444 651 27 -
VVAVVNDTVGTMMTCAY O43443 650 27 -
VVAVVNDTVGTMMTCAY HXK1_MOUSE 651 27 -
VVAVVNDTVGTMMTCAY Q64476 678 27 -
VVAVVNDTVGTMMTCAY HXK1_RAT 652 27 -
VVAVVNDTVGTMMTCAY HXK1_BOVIN 651 27 -
VVAVVNDTVGTMMTCGY HXK2_MOUSE 651 27 -
VVAVVNDTVGTMMTCGY O54892 651 27 -
VVAVVNDTVGTMMTCGY HXK2_RAT 651 27 -
VVAIVNDTVGTMMSCGY HXK3_HUMAN 657 27 -
VVAVVNDTVGTMMTCGF HXK2_HUMAN 651 27 -
VVAIVNDTVGTMMSCGY HXK3_RAT 658 27 -
VVAMVNDTVATMISCYY Q91753 192 27 -
VVAMVNDTVATMISCYY HXKH_RAT 199 27 -
VVAMVNDTVATMISCYY Q64596 232 27 -
VVAMVNDTVATMISCYY HXKP_RAT 199 27 -
VVAMVNDTVATMISCYY HXKH_MOUSE 199 27 -
VVAMVNDTVATMISCYY HXKP_MOUSE 199 27 -
VVAMVNDTVATMISCYY HXKH_HUMAN 200 27 -
VVAMVNDTVATMISCYY HXKP_HUMAN 199 27 -
VVALLNDTVGTLMACAF Q19440 217 27 -
CVAVVNDTVGTLASCAL HXK_SCHMA 191 26 -
VVALINDTTGTLVASYY HXKB_YEAST 205 26 -
VVALINDTTGTLVASYY Q05838 205 26 -
IVALINDTVGTLIASYY HXKA_YEAST 205 26 -
VAALVNDTIGTLAGGRY P93834 224 26 -
IAALVNDTVGTLAGGRY HXK_ARATH 163 26 -
IAALVNDTVGTLAGGRY Q42535 224 26 -
VVALINDTTGTLVASMY HXK_DEBOC 204 26 -
VAALVNDTVGTLMARSY HXKG_ASPNG 202 26 -
VVRLINDTTGTLVASLY HXK_KLULA 204 26 -
ITALINDTTGTMVASNY O74996 241 26 -
VVALTNDTVGTFLSHCY Q04409 213 27 -
VVALTNDTVGTYLSHCY HXKG_YEAST 212 27 -
LNAILSDTTGTLVASNY HXK1_SCHPO 208 27 -
IEAVINDTVGTLVTRAY HXK2_SCHPO 191 26 -
VSALVNDTVGTLAGGKY O64390 224 26 -
IVAFINDTVGTFANLAY O09487 175 27 -
IVAFINDTVGTFANLAY Q27647 175 27 -
VCCVLNDAVGTLMSCAY HXK_PLAFA 235 31 -
IVAFINDTVGTFANLAY O09488 175 27 -

Motif 4 width=15
Element Seqn Id St Int Rpt
VGMIVGTGCNACYME HXKP_HUMAN 222 6 -
VGLIVGTGSNACYME HXK1_HUMAN 674 6 -
VGLIVGTGSNACYME O43444 674 6 -
VGLIVGTGSNACYME O43443 673 6 -
IGLIVGTGSNACYME HXK1_MOUSE 674 6 -
IGLIVGTGSNACYME Q64476 701 6 -
IGLIVGTGTNACYME HXK1_RAT 675 6 -
VGLIVGTGSNACYME HXK1_BOVIN 674 6 -
VGLIVGTGSNACYME HXK2_MOUSE 674 6 -
VGLIVGTGSNACYME O54892 674 6 -
VGLIVGTGSNACYME HXK2_RAT 674 6 -
IGLIVGTGTNACYME HXK3_HUMAN 680 6 -
VGLIVGTGSNACYME HXK2_HUMAN 674 6 -
MGLIVGTGTNACYME HXK3_RAT 681 6 -
VGLIVGTGCNACYME Q91753 215 6 -
VGMIVGTGCNACYME HXKH_RAT 222 6 -
VGMIVGTGCNACYME Q64596 255 6 -
VGMIVGTGCNACYME HXKP_RAT 222 6 -
VGMIVGTGCNACYME HXKH_MOUSE 222 6 -
VGMIVGTGCNACYME HXKP_MOUSE 222 6 -
VGMIVGTGCNACYME HXKH_HUMAN 223 6 -
IGVIVGTGTNACYME Q19440 240 6 -
VGLIVGTGTNVAYIE HXK_SCHMA 214 6 -
MGVIFGTGVNGAYYD HXKB_YEAST 228 6 -
MGVIFGTGVNGAYYD Q05838 228 6 -
MGVIFGTGVNGAFYD HXKA_YEAST 228 6 -
VAVILGTGTNAAYVE P93834 247 6 -
AAVILGTGTNAAYVE HXK_ARATH 186 6 -
AAVILGTGTNAAYVE Q42535 247 6 -
MGLFSGTGCNGAYYD HXK_DEBOC 227 6 -
LGAIFGTGTNGAYVE HXKG_ASPNG 228 9 -
MGIIIGTGVNGAYYD HXK_KLULA 227 6 -
LGNIFGTGVNAAYYE O74996 264 6 -
IGCIFGTGTNGCYME Q04409 246 16 -
IGCIFGTGTNGCYME HXKG_YEAST 246 17 -
IGVIFGTGCNACYIE HXK1_SCHPO 231 6 -
VAVILGTGTNAAYVE O64390 247 6 -
MGLIFGTGTNGCYIE O09487 198 6 -
MGLIFGTGTNGCYIE Q27647 198 6 -
IGIILGTGSNGCYYE HXK_PLAFA 262 10 -
MGLIFGTGTNGCYIE O09488 198 6 -
MGLIFGTGTNGCYIE Q27648 198 6 -
MGIIFGTGTNGAYVE HXK2_SCHPO 216 8 -

Motif 5 width=23
Element Seqn Id St Int Rpt
QIFEKRVGGMYLGELFRRALFHL HXK2_SCHPO 280 49 -
QRYEKMISGMYLGEIVRNILIDF HXK1_HUMAN 739 50 -
QRYEKMISGMYLGEIVRNILIDF O43444 739 50 -
QRYEKMISGMYLGEIVRNILIDF O43443 738 50 -
QRFEKMISGMYLGEIVRNILIDF HXK1_MOUSE 739 50 -
QRFEKMISGMYLGEIVRNILIDF Q64476 766 50 -
QRFEKMISGMYLGEIVRNILIDF HXK1_RAT 740 50 -
QRFENMISGIYLGEIVRNILIDF HXK1_BOVIN 739 50 -
QRFEKMISGMYLGEIVRNILIDF HXK2_MOUSE 739 50 -
QRFEKMISGMYLGEIVRNILIDF O54892 739 50 -
QRFEKMISGMYLGEIVRNILIDF HXK2_RAT 739 50 -
QRFEKMISGMYLGEIVRHILLHL HXK3_HUMAN 745 50 -
QRFEKMISGMYLGEIVRNILIDF HXK2_HUMAN 739 50 -
QRFEKMISGMYLGEIVRHILLHL HXK3_RAT 746 50 -
QLYEKMIGGKYMGELVRLVLIKM Q91753 280 50 -
QLYEKIIGGKYMGELVRLVLLKL HXKH_RAT 287 50 -
QLYEKIIGGKYMGELVRLVLLKL Q64596 320 50 -
QLYEKIIGGKYMGELVRLVLLKL HXKP_RAT 287 50 -
QLYEKIIGGKYMGELVRLVLLKL HXKH_MOUSE 287 50 -
QLYEKIIGGKYMGELVRLVLLKL HXKP_MOUSE 287 50 -
QLYEKLIGGKYMGELVRLVLLRL HXKH_HUMAN 288 50 -
QLYEKLIGGKYMGELVRLVLLRL HXKP_HUMAN 287 50 -
HLYEKMISGMYMGECARVVLEDL Q19440 312 57 -
QLYEKMVSGMYLGELVRHIIVYL HXK_SCHMA 280 51 -
QTFEKMSSGYYLGEILRLALMDM HXKB_YEAST 299 56 -
QTFEKMSSGYYLGEILRLALMDM Q05838 299 56 -
QAFEKMTSGYYLGELLRLVLLEL HXKA_YEAST 299 56 -
QILEKIISGMYLGEILRRVLLKM P93834 312 50 -
QILEKIISGMYLGEILRRVLLKM HXK_ARATH 251 50 -
QILEKIISGMYLGEILRRVLLKM Q42535 312 50 -
QAFEKMISGYYLGEVLRLILLDL HXK_DEBOC 298 56 -
QMFEKRVSGMFLGEILRRVMLDM HXKG_ASPNG 300 57 -
QAFEKMTSGYYLGEIMRLVLLDL HXK_KLULA 298 56 -
QTFEKMSAGYYLGELLRLVLLDL O74996 335 56 -
HLFEKRISGMYLGELLRNILVDL Q04409 320 59 -
HLFEKRVSGMFLGEVLRNILVDL HXKG_YEAST 320 59 -
QTYEKMIAGCYLGDILRRILLDL HXK1_SCHPO 299 53 -
QIFEKMTSGMYLGEILRRVLTRV O64390 312 50 -
QRYEKMISGIYMGWLARLAIREL O09487 264 51 -
QRYEKMISGIYMGWLARLAIREL Q27647 264 51 -
QLFEKMISGAYLGEIVRRFMVNV HXK_PLAFA 319 42 -
HYFEKMISGIYMGWLARLAIREL O09488 264 51 -
HYFEKMISGIYMGWLARLAIREL Q27648 264 51 -

Motif 6 width=23
Element Seqn Id St Int Rpt
VLSLCNIVATRGARLDAAGVLGI O64390 396 61 -
VKTVCGVVSRRAAQLCGAGMAAV HXK1_HUMAN 819 57 -
VKTVCGVVSRRAAQLCGAGMAAV O43444 819 57 -
VKTVCGVVSRRAAQLCGAGMAAV O43443 818 57 -
VKTVCGVVSKRAAQLCGAGMAAV HXK1_MOUSE 819 57 -
VKTVCGVVSKRAAQLCGAGMAAV Q64476 846 57 -
VKTVCGVVSKRAAQLCGAGMAAV HXK1_RAT 820 57 -
VKTVCGVVSKRAAQLCGAGMAAV HXK1_BOVIN 819 57 -
VKEVCTVVARRAAQLCGAGMAAV HXK2_MOUSE 819 57 -
VKEVCTVVARRAAQLCGAGMAAV O54892 819 57 -
VKEVCTVVARRAAQLCGAGMAAV HXK2_RAT 819 57 -
VLEVCQAVSQRAAQLCGAGVAAV HXK3_HUMAN 825 57 -
VKEVCTVVARRAAQLCGAGMAAV HXK2_HUMAN 819 57 -
VLEVCQAVSRRAAQLCGAGVAAV HXK3_RAT 826 57 -
VRLACESVSTRAAIMCSAGLAGI Q91753 360 57 -
VRRACESVSTRAAHMCSAGLAGV HXKH_RAT 367 57 -
VRRACESVSTRAAHMCSAGLAGV Q64596 400 57 -
VRRACESVSTRAAHMCSAGLAGV HXKP_RAT 367 57 -
VRRACESVSTRAAHMCSAGLAGV HXKH_MOUSE 367 57 -
VRRACESVSTRAAHMCSAGLAGV HXKP_MOUSE 367 57 -
VRRACESVSTRAAHMCSAGLAGV HXKH_HUMAN 368 57 -
VRRACESVSTRAAHMCSAGLAGV HXKP_HUMAN 367 57 -
VAYVCSLISTRAAHLTAAGIAML Q19440 397 62 -
VRYACEMVVKRAAYLAGAGIACI HXK_SCHMA 363 60 -
IRRLSELIGARAARLSVCGIAAI HXKB_YEAST 381 59 -
IRRLSELIGARAARLSVCGIAAI Q05838 381 59 -
IRRLCELIGTRAARLAVCGIAAI HXKA_YEAST 381 59 -
VISLCNIIASRGARLSAAGIYGI P93834 395 60 -
VISLCNIIATRGARLSAAGIYGI HXK_ARATH 334 60 -
VISLCNIIATRGARLSAAGIYGI Q42535 395 60 -
IRRLAELIGERSARLSICGIAAI HXK_DEBOC 380 59 -
IQTVVHAIGKRAARLSAVPLAAI HXKG_ASPNG 393 70 -
IRKLAELVGTRAARLTVCGVSAI HXK_KLULA 380 59 -
IRRLAELIGTRSARISACGVAAI O74996 424 66 -
IQNLVRSITRRSAYLAAVPIAAI Q04409 407 64 -
IQKLVRAISRRSAYLAAVPLAAI HXKG_YEAST 407 64 -
IRRACELIGTRSARLSACGVCAL HXK1_SCHPO 381 59 -
LKNITEAVVKRAAYLSAAATVAL O09487 355 68 -
LKAITEAVVKRAAYLSAAATVAL Q27647 355 68 -
LRKICEAVYNRSAALARGTIAAI HXK_PLAFA 395 53 -
LKNITEAVVKRAAYLAAAATVCL O09488 355 68 -
LKAITEAVVKRAAYLAAAATVCL Q27648 355 68 -
LWDAAHAIGRRAARMSAVPIASL HXK2_SCHPO 360 57 -

Motif 7 width=17
Element Seqn Id St Int Rpt
QLSKDGSGLGAVIVAAA Q27648 424 46 -
LLSEDGSGKGAALITAV HXK1_HUMAN 891 49 -
LLSEDGSGKGAALITAV O43444 891 49 -
LLSEDGSGKGAALITAV O43443 890 49 -
LLSEDGSGKGAALITAV Q64476 918 49 -
LLSEDGSGKGAALITAV HXK1_RAT 892 49 -
LLSEDGSGKGAALITAV HXK1_BOVIN 891 49 -
LESEDGSGKGAALITAV HXK2_MOUSE 891 49 -
LESEDGSGKGAALITAV O54892 891 49 -
LESEDGSGKGAALITAV HXK2_RAT 891 49 -
LQSEDGSGKGAALVTAV HXK3_HUMAN 897 49 -
LQSEDGSGKGAALITAV HXK2_HUMAN 891 49 -
LQSEDGSGKGAALVTRV HXK3_RAT 898 49 -
IQSEEGSGRGAALISAV Q91753 432 49 -
IESEEGSGRGAALVSAV HXKH_RAT 439 49 -
IESEEGSGRGAALVSAV Q64596 472 49 -
IESEEGSGRGAALVSAV HXKP_RAT 439 49 -
IESEEGSGRGAALVSAV HXKH_MOUSE 439 49 -
IESEEGSGRGAALVSAV HXKP_MOUSE 439 49 -
IESEEGSGRGAALVSAV HXKH_HUMAN 440 49 -
IESEEGSGRGAALVSAV HXKP_HUMAN 439 49 -
LLSEDGSGKGAALITAV HXK1_MOUSE 891 49 -
MLSEDGSGRGAALVAAV Q19440 464 44 -
RLSEDGSGKGAAAIAAS HXK_SCHMA 430 44 -
VPAEDGSGAGAAVIAAL HXKB_YEAST 454 50 -
VPAEDGSGPGAAVIAAL Q05838 454 50 -
VPAEDGSGAGAAVIAAL HXKA_YEAST 453 49 -
ILSNDGSGVGAALLAAS P93834 472 54 -
THSNDGSGIGAALLAAS HXK_ARATH 411 54 -
THSNDGSGIGAALLAAS Q42535 472 54 -
VPAEDGLGAGAAIIAAL HXK_DEBOC 450 47 -
GISKDGSGVGAALIALV HXKG_ASPNG 468 52 -
VAAEDGSGVGAAIIACL HXK_KLULA 453 50 -
VPAEDGSGVGAALCAAL O74996 497 50 -
RLAKDGSGVGAALCALV Q04409 483 53 -
KIAKDGSGVGAALCALV HXKG_YEAST 483 53 -
IPAEDGSGVGAALVSAL HXK1_SCHPO 450 46 -
GIAKDGSGIGAALCALQ HXK2_SCHPO 430 47 -
VHSNDGSGIGAALLRAS O64390 473 54 -
QLSKDGSGLGAVIVAAA O09487 424 46 -
QLSKDGSGLGAVIVAAA Q27647 424 46 -
IPADDGSGKGAAITAAV HXK_PLAFA 466 48 -
QLSKDGSGLGAVIVAAA O09488 424 46 -