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PR00450

Identifier
RECOVERIN  [View Relations]  [View Alignment]  
Accession
PR00450
No. of Motifs
7
Creation Date
12-DEC-1995  (UPDATE 29-JUL-1999)
Title
Recoverin family signature
Database References

INTERPRO; IPR001125
Literature References
1. TANAKA, T., AMES, J.B., HARVEY, T.S., STRYER, L. AND IKURA, M.
Sequestration of the membrane-targeting myristoyl group of recoverin
in the calcium-free state.
NATURE 376 444-447 (1995).

Documentation
Recoverin, a retinal calcium-binding protein, participates in the recovery
phase of visual excitation and in adaption to light [1]. The Ca2+-bound
form of recoverin prolongs the photoresponse, presumably by blocking
phosphorylation of photoexcited rhodopsin. Recoverin contains a covalently-
attached myristoyl group, or acyl group, at its N-terminus, and 2 Ca2+-
binding sites. Ca2+ binding to myristoylated recoverin induces its
translocation to bilayer membranes, indicating that the myristoyl group
is essential to the read-out of calcium signals (calcium-myristoyl switch).
 
The solution structure of Ca2+-free, myristoylated recombinant recoverin
reveals the myristoyl group to be sequestered in a deep hydrophobic 
pocket formed by several aromatic and other hydrophobic residues from
5 flanking helices [1]. Overall, the structure contains 11 helices and 2
pairs of short anti-parallel beta-sheets. Four pairs of helices constitute
4 EF-hand type helix-loop-helix structural motifs.  
 
A moderate degree of sequence similarity exists between recoverin and a
group of homologues that includes visinin, hippocalcin, neurocalcin,
S-modulin, visinin-like protein, and frequenin. Several hydrophobic
residues are conserved within these sequences, especially the aromatic
residues that contribute to the myristoyl-binding pocket, suggesting that
the structure of the pocket is similar in all family members.
 
RECOVERIN is a 7-element fingerprint that provides a signature for the
recoverin family. The fingerprint was derived from an initial alignment of
9 sequences: the motifs were drawn from short conserved regions spanning
virtually the full alignment length - motifs 1 and 2 encode the first 2
helices; motif 3 spans helices 4 and 5 and the short intervening strand;
motif 4 encodes helix 6; motif 5 spans strand 3 and helix 7; motif 6
encodes part of helix 9; and motif 7 spans the final 2 helices. Two
iterations on OWL26.3 were required to reach convergence, at which point
a true set comprising 23 sequences was identified. Several partial matches
were also found, including sequences that fail to make significant matches
with one or more motifs and a number of fragments.
 
An update on SPTR37_9f identified a true set of 26 sequences, and 11
partial matches.
Summary Information
  26 codes involving  7 elements
0 codes involving 6 elements
8 codes involving 5 elements
1 codes involving 4 elements
2 codes involving 3 elements
0 codes involving 2 elements
Composite Feature Index
726262626262626
60000000
50888808
40111100
31110111
20000000
1234567
True Positives
APLC_APLCA    FREQ_DROME    HIPP_HUMAN    HIPP_RAT      
NCAH_DROME NCS1_CAEEL NCS1_RAT NCS1_SCHPO
NCS1_XENLA NCS1_YEAST NCS2_CAEEL NECD_BOVIN
NECX_APLCA O12953 O73924 RECO_BOVIN
RECO_HUMAN RECO_MOUSE SMOD_RANCA VIS1_HUMAN
VIS1_RAT VIS2_RAT VIS3_CHICK VIS3_HUMAN
VIS3_RAT VISI_CHICK
True Positive Partials
Codes involving 5 elements
GCA2_BOVIN GCAP_BOVIN GCAP_HUMAN GCAP_MOUSE
O73761 O73762 P79880 P79881
Codes involving 4 elements
O73763
Codes involving 3 elements
CALB_NAEGR Q21189
Sequence Titles
APLC_APLCA  APLYCALCIN - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE). 
FREQ_DROME FREQUENIN (D-FRQ) - DROSOPHILA MELANOGASTER (FRUIT FLY).
HIPP_HUMAN NEURON SPECIFIC CALCIUM-BINDING PROTEIN HIPPOCALCIN (BDR-2) - HOMO SAPIENS (HUMAN).
HIPP_RAT NEURON SPECIFIC CALCIUM-BINDING PROTEIN HIPPOCALCIN (P23K) - RATTUS NORVEGICUS (RAT).
NCAH_DROME NEUROCALCIN HOMOLOG - DROSOPHILA MELANOGASTER (FRUIT FLY).
NCS1_CAEEL NEURONAL CALCIUM SENSOR 1 (NCS-1) - CAENORHABDITIS ELEGANS.
NCS1_RAT NEURONAL CALCIUM SENSOR 1 (NCS-1) - RATTUS NORVEGICUS (RAT), AND GALLUS GALLUS (CHICKEN).
NCS1_SCHPO HYPOTHETICAL CALCIUM-BINDING PROTEIN C18B11.04 IN CHROMOSOME I - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
NCS1_XENLA NEURONAL CALCIUM SENSOR 1 (NCS-1) (FREQUENIN) - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
NCS1_YEAST CALCIUM-BINDING PROTEIN NCS-1 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
NCS2_CAEEL NEURONAL CALCIUM SENSOR 2 (NCS-2) - CAENORHABDITIS ELEGANS.
NECD_BOVIN NEUROCALCIN DELTA - BOS TAURUS (BOVINE).
NECX_APLCA NEUROCALCIN - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE).
O12953 NEUROCALCIN - GALLUS GALLUS (CHICKEN).
O73924 PHOTORECEPTOR PROTEIN S26 - RANA CATESBEIANA (BULL FROG).
RECO_BOVIN RECOVERIN (P26) - BOS TAURUS (BOVINE).
RECO_HUMAN RECOVERIN (CANCER ASSOCIATED RETINOPATHY PROTEIN) (CAR PROTEIN) - HOMO SAPIENS (HUMAN).
RECO_MOUSE RECOVERIN (CANCER ASSOCIATED RETINOPATHY PROTEIN) (CAR PROTEIN) (23 KD PHOTORECEPTOR CELL-SPECIFIC PROTEIN) - MUS MUSCULUS (MOUSE).
SMOD_RANCA S-MODULIN (SENSITIVITY-MODULATING PROTEIN) - RANA CATESBEIANA (BULL FROG).
VIS1_HUMAN VISININ-LIKE PROTEIN 1 (VILIP-1) - HOMO SAPIENS (HUMAN).
VIS1_RAT VISININ-LIKE PROTEIN 1 (VILIP-1) (NEURAL VISININ-LIKE PROTEIN 1) (NVL-1) (NVP-1) (21 KD CABP) (NEUROCALCIN ALPHA) - MUS MUSCULUS (MOUSE), RATTUS NORVEGICUS (RAT), BOS TAURUS (BOVINE), AND GALLUS GALLUS (CHICKEN).
VIS2_RAT VISININ-LIKE PROTEIN 2 (VILIP-2) (NEURAL VISININ-LIKE PROTEIN 2) (NVL-2) (NVP-2) - RATTUS NORVEGICUS (RAT).
VIS3_CHICK REM-1 PROTEIN - GALLUS GALLUS (CHICKEN).
VIS3_HUMAN VISININ-LIKE PROTEIN 3 (VILIP-3) (CALCIUM-BINDING PROTEIN BDR-1) (HLP2) - HOMO SAPIENS (HUMAN).
VIS3_RAT VISININ-LIKE PROTEIN 3 (VILIP-3) (NEURAL VISININ-LIKE PROTEIN 3) (NVL-3) (NVP-3) - MUS MUSCULUS (MOUSE), AND RATTUS NORVEGICUS (RAT).
VISI_CHICK VISININ - GALLUS GALLUS (CHICKEN).

GCA2_BOVIN GUANYLATE CYCLASE ACTIVATING PROTEIN 2 (GCAP 2) (RETINAL GUANYLYL CYCLASE ACTIVATOR PROTEIN P24) - BOS TAURUS (BOVINE).
GCAP_BOVIN GUANYLATE CYCLASE ACTIVATING PROTEIN 1 (GCAP 1) - BOS TAURUS (BOVINE).
GCAP_HUMAN GUANYLATE CYCLASE ACTIVATING PROTEIN 1 (GCAP 1) - HOMO SAPIENS (HUMAN).
GCAP_MOUSE GUANYLATE CYCLASE ACTIVATING PROTEIN 1 (GCAP 1) - MUS MUSCULUS (MOUSE).
O73761 GUANYLATE CYCLASE ACTIVATING PROTEIN 1 - RANA PIPIENS (NORTHERN LEOPARD FROG).
O73762 GUANYLATE CYCLASE ACTIVATING PROTEIN 2 - RANA PIPIENS (NORTHERN LEOPARD FROG).
P79880 GCAP1 - GALLUS GALLUS (CHICKEN).
P79881 GCAP2 - GALLUS GALLUS (CHICKEN).

O73763 GUANYLATE CYCLASE INHIBITORY PROTEIN - RANA PIPIENS (NORTHERN LEOPARD FROG).

CALB_NAEGR CALCINEURIN B SUBUNIT (PROTEIN PHOSPHATASE 2B REGULATORY SUBUNIT) - NAEGLERIA GRUBERI.
Q21189 SIMILARITY TO NEURONAL CALCIUM BINDING PROTEINS.
Scan History
OWL26_3    2  100  NSINGLE    
SPTR37_9f 2 50 NSINGLE
Initial Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
LSKEILEELQLNTKF SMOD_RANCA 8 8 -
LKQDTIDRLTTDTYF FREQ_DROME 7 7 -
LSREVLQELRASTRY VISI_CHICK 8 8 -
LAPEVMEDLVKSTEF HSU14747 8 8 -
LRPEVLQDLRENTEF S47565 8 8 -
LRPEVLQDLREHTEF VIS3_RAT 7 7 -
LAPEVMEDLVKSTEF VIS1_RAT 7 7 -
LAPEELEDLVQNTEF VIS2_RAT 7 7 -
LSKEILEELQLNTKF RECO_HUMAN 8 8 -

Motif 2 width=20
Element Seqn Id St Int Rpt
FTQEELCTWYQSFLKECPSG SMOD_RANCA 22 -1 -
FSEEELCSWYQSFLKDCPTG RECO_HUMAN 22 -1 -
FSEQELKQWYKGFLKDCPSG VIS2_RAT 21 -1 -
FNEHELKQWYKGFLKDCPSG HSU14747 22 -1 -
FNEHELKQWYKGFLKDCPSG VIS1_RAT 21 -1 -
FTDHELQEWYKGFLKDCPTG S47565 22 -1 -
FTDHELQEWYKGFLKDCPTG VIS3_RAT 21 -1 -
YTEEELSRWYEGFQRQCPDG VISI_CHICK 22 -1 -
FTEKEIRQWHKGFLKDCPNG FREQ_DROME 21 -1 -

Motif 3 width=22
Element Seqn Id St Int Rpt
VFRSFDSNLDGTLDFKEYVIAL RECO_HUMAN 68 26 -
VFRTFDTNGDGTIDFREFIIAL S47565 68 26 -
AFRTFDKIGDGTIDFREFICAL HSU14747 68 26 -
VFRTFDTNSDGTIDFREFIIAL VIS3_RAT 67 26 -
AFRTFDKNGDGTIDFREFICAL VIS1_RAT 67 26 -
AFRTFDKNGDGTIDFREFICAL VIS2_RAT 67 26 -
VFRSFDANNDGTLDFKEYMIAL SMOD_RANCA 68 26 -
VFRVFDENNDGSIEFEEFIRAL FREQ_DROME 67 26 -
VFRSFDTNDDGTLDFREYIIAL VISI_CHICK 68 26 -

Motif 4 width=20
Element Seqn Id St Int Rpt
TSRGSFEQKLNWAFNMYDLD VIS1_RAT 91 2 -
TSRGXFEQKLNWAFNMYDLD HSU14747 92 2 -
TSSGKTHLKLEWAFSLFDVD VISI_CHICK 92 2 -
TSKGNLDEKLQWAFRLYDVD FREQ_DROME 91 2 -
TSRGKLEQKLKWAFSMYDLD S47565 92 2 -
TSSGKANQKLEWAFCLYDVD SMOD_RANCA 92 2 -
TTAGKTNQKLEWAFSLYDVD RECO_HUMAN 92 2 -
TSRGSFEQKLNWAFEMYDLD VIS2_RAT 91 2 -
TSRGKLEQKLKWAFSMYDLD VIS3_RAT 91 2 -

Motif 5 width=19
Element Seqn Id St Int Rpt
GYISRSEMLEIVQAIYKMV S47565 114 2 -
GYISRSEMLEIVQAIYKMV VIS3_RAT 113 2 -
GKITRVEMLEIIEAIYKMV VIS1_RAT 113 2 -
GRITRLEMLEIIEAIYKMV VIS2_RAT 113 2 -
GTISKNEVLEIVMAIFKMI RECO_HUMAN 114 2 -
GTINKKEVLEIITAIFKMI SMOD_RANCA 114 2 -
GYITREEMYNIVDAIYQMV FREQ_DROME 113 2 -
GEVSKSEVLEIITAIFKMI VISI_CHICK 114 2 -
GKITXXEMLEIIEAIYKMV HSU14747 114 2 -

Motif 6 width=16
Element Seqn Id St Int Rpt
QSEDENTPQKRVDKIF FREQ_DROME 136 4 -
MPEDESTPEKRTDKIF S47565 138 5 -
MNEDGLTPEQRVDKIF HSU14747 140 7 -
MPEDESTPEKRTDKIF VIS3_RAT 137 5 -
MNEDGLTPEQRVDKIF VIS1_RAT 139 7 -
MNQDGLTPQQRVDKIF VIS2_RAT 139 7 -
LPEDENSPQKRADKLW VISI_CHICK 140 7 -
LPDDENTPEKRAEKIW RECO_HUMAN 140 7 -
LPEDENTPEKRTNKIW SMOD_RANCA 140 7 -

Motif 7 width=21
Element Seqn Id St Int Rpt
ITLGEFREAAKSDPSIVLLLQ HSU14747 166 10 -
ITLDEFKEAAKSDPSIVLLLQ VIS1_RAT 165 10 -
IAEGEFIDGVMKNDAIMRLIQ VISI_CHICK 166 10 -
LTLEEFREGSKADPRIVQALS FREQ_DROME 162 10 -
LTEGEFIQGIVKNKEILRLIQ SMOD_RANCA 166 10 -
LTEKEFIEGTLANKEILRLIQ RECO_HUMAN 166 10 -
ITLEEFKEAAKSDPSIVLLLQ VIS2_RAT 165 10 -
LSLEEFIKGAKSDPSIVRLLQ VIS3_RAT 163 10 -
LSLEEFIRGAKSDPSIVRLLQ S47565 164 10 -
Final Motifs
Motif 1  width=15
Element Seqn Id St Int Rpt
LRPEVLQDLRENTEF VIS3_CHICK 7 7 -
LKPEVLEDLKQNTEF NCAH_DROME 7 7 -
LRPEVLQDLREHTEF VIS3_RAT 7 7 -
LRPEMLQDLRENTEF HIPP_RAT 7 7 -
LRPEMLQDLRENTEF HIPP_HUMAN 7 7 -
LRPEVMQDLLESTDF O12953 8 8 -
LRPEVMQDLLESTDF NECD_BOVIN 7 7 -
LRPEVLQDLREKTEF VIS3_HUMAN 7 7 -
LKPEVLEDLRHQTQF NECX_APLCA 7 7 -
LAPEVMEDLVKSTEF VIS1_RAT 7 7 -
LAPEELEDLVQNTEF VIS2_RAT 7 7 -
LAPEVMEDLVKSTEF VIS1_HUMAN 7 7 -
LKPEVVEELTRKTYF NCS1_XENLA 7 7 -
LKPEVVEELTRKTYF NCS1_RAT 7 7 -
LSKEILEELQLNTKF RECO_BOVIN 8 8 -
LSQDQLQDLVRSTRF NCS1_SCHPO 7 7 -
LSKEILEELQLNTKF RECO_MOUSE 8 8 -
LSKEILEELQLNTKF RECO_HUMAN 8 8 -
LKSSQIRDLAEQTYF NCS1_CAEEL 7 7 -
LSKEILEELQLNTKF SMOD_RANCA 8 8 -
LKPEEVEELKQQTYF APLC_APLCA 7 7 -
LKQDTIDRLTTDTYF FREQ_DROME 7 7 -
LSKEILEDLKMNTKY O73924 9 9 -
LSKDDLTCLKQSTYF NCS1_YEAST 7 7 -
LSREVLQELRASTRY VISI_CHICK 8 8 -
LSKEDLEFLKKNTNF NCS2_CAEEL 9 9 -

Motif 2 width=20
Element Seqn Id St Int Rpt
FTDHELQEWYKGFLKDCPTG VIS3_CHICK 21 -1 -
FTDAEIQEWYKGFLKDCPSG NCAH_DROME 21 -1 -
FTDHELQEWYKGFLKDCPTG VIS3_RAT 21 -1 -
FSELELQEWYKGFLKDCPTG HIPP_RAT 21 -1 -
FSELELQEWYKGFLKDCPTG HIPP_HUMAN 21 -1 -
FTEHEIQEWYKGFLRDCPSG O12953 22 -1 -
FTEHEIQEWYKGFLRDCPSG NECD_BOVIN 21 -1 -
FTDHELQEWYKGFLKDCPTG VIS3_HUMAN 21 -1 -
FSEEELQEWYKGSLKDCPSG NECX_APLCA 21 -1 -
FNEHELKQWYKGFLKDCPSG VIS1_RAT 21 -1 -
FSEQELKQWYKGFLKDCPSG VIS2_RAT 21 -1 -
FNEHELKQWYKGFLKDCPSG VIS1_HUMAN 21 -1 -
FTEKEVQQWYKGFIKDCPSG NCS1_XENLA 21 -1 -
FTEKEVQQWYKGFIKDCPSG NCS1_RAT 21 -1 -
FTEEELSSWYQSFLKECPSG RECO_BOVIN 22 -1 -
FDKKELQQWYKGFFKDCPSG NCS1_SCHPO 21 -1 -
FTEEELSAWYQSFLKECPSG RECO_MOUSE 22 -1 -
FSEEELCSWYQSFLKDCPTG RECO_HUMAN 22 -1 -
FTEKEIKQWYKGFVRDCPNG NCS1_CAEEL 21 -1 -
FTQEELCTWYQSFLKECPSG SMOD_RANCA 22 -1 -
FTEAEIKQWHKGFRKDCPDG APLC_APLCA 21 -1 -
FTEKEIRQWHKGFLKDCPNG FREQ_DROME 21 -1 -
YSEEELFNWYESFKKQCPDG O73924 23 -1 -
FDRREIQQWHKGFLRDCPSG NCS1_YEAST 21 -1 -
YTEEELSRWYEGFQRQCPDG VISI_CHICK 22 -1 -
FTEEQIKEWYKGFVQDCPKG NCS2_CAEEL 23 -1 -

Motif 3 width=22
Element Seqn Id St Int Rpt
VFRTFDTNGDGTIDFREFIIAL VIS3_CHICK 67 26 -
VFRTFDANGDGTIDFREFLCAL NCAH_DROME 67 26 -
VFRTFDTNSDGTIDFREFIIAL VIS3_RAT 67 26 -
VFRTFDTNSDGTIDFREFIIAL HIPP_RAT 67 26 -
VFRTFDTNSDGTIDFREFIIAL HIPP_HUMAN 67 26 -
VFRTFDANGDGTIDFREFIIAL O12953 68 26 -
VFRTFDANGDGTIDFREFIIAL NECD_BOVIN 67 26 -
VFRTFDTNGDGTIDFREFIIGL VIS3_HUMAN 67 26 -
VFRTFDTNGDGSIDFREFICAL NECX_APLCA 67 26 -
AFRTFDKNGDGTIDFREFICAL VIS1_RAT 67 26 -
AFRTFDKNGDGTIDFREFICAL VIS2_RAT 67 26 -
AFRTFDKIGDGTIDFREFICAL VIS1_HUMAN 67 26 -
VFNVFDENKDGRIEFSEFIQAL NCS1_XENLA 67 26 -
VFNVFDENKDGRIEFSEFIQAL NCS1_RAT 67 26 -
VFRSFDANSDGTLDFKEYVIAL RECO_BOVIN 68 26 -
VFNVFDADKNGYIDFKEFICAL NCS1_SCHPO 67 26 -
VFRSFDANSDGTLDFKEYVIAL RECO_MOUSE 68 26 -
VFRSFDSNLDGTLDFKEYVIAL RECO_HUMAN 68 26 -
VFKVFDENKDGAIEFHEFIRAL NCS1_CAEEL 67 26 -
VFRSFDANNDGTLDFKEYMIAL SMOD_RANCA 68 26 -
VFNVFDENKDGFISFGEFLQAL APLC_APLCA 67 26 -
VFRVFDENNDGSIEFEEFIRAL FREQ_DROME 67 26 -
VFRSFDTNDDGTLDFREYIIAL O73924 69 26 -
LFTVFDKDNNGFIHFEEFITVL NCS1_YEAST 67 26 -
VFRSFDTNDDGTLDFREYIIAL VISI_CHICK 68 26 -
VFRTFDTDNSGFIDFKEFLLAI NCS2_CAEEL 69 26 -

Motif 4 width=20
Element Seqn Id St Int Rpt
TSRGKLEQKLKWAFSMYDLD VIS3_CHICK 91 2 -
TSRGKLEQKLKWAFSMYDLD NCAH_DROME 91 2 -
TSRGKLEQKLKWAFSMYDLD VIS3_RAT 91 2 -
TSRGRLEQKLMWAFSMYDLD HIPP_RAT 91 2 -
TSPGRLEQKLMWAFSMYDLD HIPP_HUMAN 91 2 -
TSRGKLEQKLKWAFSMYDLD O12953 92 2 -
TSRGKLEQKLKWAFSMYDLD NECD_BOVIN 91 2 -
TRGGKLEQKLKWAFSMYDLD VIS3_HUMAN 91 2 -
TSRGQLEQKLRWAFSMYDLD NECX_APLCA 91 2 -
TSRGSFEQKLNWAFNMYDLD VIS1_RAT 91 2 -
TSRGSFEQKLNWAFEMYDLD VIS2_RAT 91 2 -
TSRGXFEQKLNWAFNMYDLD VIS1_HUMAN 91 2 -
TSRGTLDEKLRWAFKLYDLD NCS1_XENLA 91 2 -
TSRGTLDEKLRWAFKLYDLD NCS1_RAT 91 2 -
TSAGKTNQKLEWAFSLYDVD RECO_BOVIN 92 2 -
TSRGELNDKLIWAFQLYDLD NCS1_SCHPO 91 2 -
TTAGKPTQKLEWAFSLYDVD RECO_MOUSE 92 2 -
TTAGKTNQKLEWAFSLYDVD RECO_HUMAN 92 2 -
TSRGNLDEKLHWAFKLYDLD NCS1_CAEEL 91 2 -
TSSGKANQKLEWAFCLYDVD SMOD_RANCA 92 2 -
TSRGTVEEKLKWAFRLYDLD APLC_APLCA 91 2 -
TSKGNLDEKLQWAFRLYDVD FREQ_DROME 91 2 -
TSSGKTSLKLEWAFSLFDVD O73924 93 2 -
TSRGTLEEKLSWAFELYDLN NCS1_YEAST 91 2 -
TSSGKTHLKLEWAFSLFDVD VISI_CHICK 92 2 -
TSSGTPEQKLEWAFRMYDID NCS2_CAEEL 93 2 -

Motif 5 width=19
Element Seqn Id St Int Rpt
GYISRGEMLEIVQAIYKMV VIS3_CHICK 113 2 -
GYISRQEMLEIVTAIYKMV NCAH_DROME 113 2 -
GYISRSEMLEIVQAIYKMV VIS3_RAT 113 2 -
GYISREEMLEIVQAIYKMV HIPP_RAT 113 2 -
GYISREEMLEIVQAIYKMV HIPP_HUMAN 113 2 -
GYISKSEMLEIVQAIYKMV O12953 114 2 -
GYISKAEMLEIVQAIYKMV NECD_BOVIN 113 2 -
GYISRSEMLEIVQAIYKMV VIS3_HUMAN 113 2 -
GYISRQEMLEIVTAIYKMV NECX_APLCA 113 2 -
GKITRVEMLEIIEAIYKMV VIS1_RAT 113 2 -
GRITRLEMLEIIEAIYKMV VIS2_RAT 113 2 -
GKITXXEMLEIIEAIYKMV VIS1_HUMAN 113 2 -
GYITRNEMLDIVDAIYQMV NCS1_XENLA 113 2 -
GYITRNEMLDIVDAIYQMV NCS1_RAT 113 2 -
GTISKNEVLEIVTAIFKMI RECO_BOVIN 114 2 -
GLISYDEMLRIVDAIYKMV NCS1_SCHPO 113 2 -
GTISKNEVLEIVMAIFKMI RECO_MOUSE 114 2 -
GTISKNEVLEIVMAIFKMI RECO_HUMAN 114 2 -
GFITRNEMLSIVDSIYKMV NCS1_CAEEL 113 2 -
GTINKKEVLEIITAIFKMI SMOD_RANCA 114 2 -
GFITRDELLDIVDAIYRMV APLC_APLCA 113 2 -
GYITREEMYNIVDAIYQMV FREQ_DROME 113 2 -
GEVSKVEVLEIISAIFKMI O73924 115 2 -
GYITFDEMLTIVASVYKMM NCS1_YEAST 113 2 -
GEVSKSEVLEIITAIFKMI VISI_CHICK 114 2 -
GTIDEKEMIKIIEAIYEML NCS2_CAEEL 115 2 -

Motif 6 width=16
Element Seqn Id St Int Rpt
MPEDESTPEKRTDKIF VIS3_CHICK 137 5 -
MPEDESTPEKRTDKIF NCAH_DROME 137 5 -
MPEDESTPEKRTDKIF VIS3_RAT 137 5 -
MPEDESTPEKRTEKIF HIPP_RAT 137 5 -
MPEDESTPEKRTEKIF HIPP_HUMAN 137 5 -
MPEDESTPEKRTEKIF O12953 138 5 -
MPEDESTPEKRTEKIF NECD_BOVIN 137 5 -
MPEDESTPEKRTDKIF VIS3_HUMAN 137 5 -
MPEDESTPERRTDKIF NECX_APLCA 137 5 -
MNEDGLTPEQRVDKIF VIS1_RAT 139 7 -
MNQDGLTPQQRVDKIF VIS2_RAT 139 7 -
MNEDGLTPEQRVDKIF VIS1_HUMAN 139 7 -
LPEEENTPEKRVDRIF NCS1_XENLA 137 5 -
LPEEENTPEKRVDRIF NCS1_RAT 137 5 -
LPEDENTPEKRAEKIW RECO_BOVIN 140 7 -
LPEDEDTPEKRVNKIF NCS1_SCHPO 137 5 -
LPDDENTPEKRAEKIW RECO_MOUSE 140 7 -
LPDDENTPEKRAEKIW RECO_HUMAN 140 7 -
LPEEENTPEKRVDRIF NCS1_CAEEL 137 5 -
LPEDENTPEKRTNKIW SMOD_RANCA 140 7 -
LPEEENTPEKRVNRIF APLC_APLCA 137 5 -
QSEDENTPQKRVDKIF FREQ_DROME 136 4 -
LPEDENTPQKRADKLW O73924 141 7 -
LNEDEATPEMRVKKIF NCS1_YEAST 137 5 -
LPEDENSPQKRADKLW VISI_CHICK 140 7 -
TKSADDSPRKRAKMIF NCS2_CAEEL 138 4 -

Motif 7 width=21
Element Seqn Id St Int Rpt
LSLEEFIKGAKSDPSIVRLLQ VIS3_CHICK 163 10 -
LSLEEFIEGAKSDPSIVRLLQ NCAH_DROME 163 10 -
LSLEEFIKGAKSDPSIVRLLQ VIS3_RAT 163 10 -
LSLEEFIRGAKSDPSIVRLLQ HIPP_RAT 163 10 -
LSLEEFIRGAKSDPSIVRLLQ HIPP_HUMAN 163 10 -
LSLEEFIRGAKSDPSIVRLLQ O12953 164 10 -
LSLEEFIRGAKSDPSIVRLLQ NECD_BOVIN 163 10 -
LSLEEFIRGAKSDPSIVRLLQ VIS3_HUMAN 163 10 -
LSIDEFIEGAKSDPSIVRLLQ NECX_APLCA 163 10 -
ITLDEFKEAAKSDPSIVLLLQ VIS1_RAT 165 10 -
ITLEEFKEAAKSDPSIVLLLQ VIS2_RAT 165 10 -
ITLGEFREAAKSDPSIVLLLQ VIS1_HUMAN 165 10 -
LTLQEFQEGSKADPSIVQALS NCS1_XENLA 163 10 -
LTLQEFQEGSKADPSIVQALS NCS1_RAT 163 10 -
LTEKEFIEGTLANKEILRLIQ RECO_BOVIN 166 10 -
LTLEEFCEGSKRDPTIVSALS NCS1_SCHPO 163 10 -
LTEEEFIEGTLANKEILRLIQ RECO_MOUSE 166 10 -
LTEKEFIEGTLANKEILRLIQ RECO_HUMAN 166 10 -
LTLEEFKEGAKADPSIVHALS NCS1_CAEEL 163 10 -
LTEGEFIQGIVKNKEILRLIQ SMOD_RANCA 166 10 -
LTFDEFLEGSKEDPTIIQALT APLC_APLCA 163 10 -
LTLEEFREGSKADPRIVQALS FREQ_DROME 162 10 -
IAEGEFIQGVMMNDEIMRLIQ O73924 167 10 -
ITLDEFREGSKVDPSIIGALN NCS1_YEAST 163 10 -
IAEGEFIDGVMKNDAIMRLIQ VISI_CHICK 166 10 -
LTLKEFVDGCLADKELFQILT NCS2_CAEEL 164 10 -