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PR00441

Identifier
GPROTEINAI  [View Relations]  [View Alignment]  
Accession
PR00441
No. of Motifs
5
Creation Date
12-JUN-1995  (UPDATE 17-DEC-1999)
Title
G-protein alpha subunit group I signature
Database References
PRINTS; PR00318 GPROTEINA
INTERPRO; IPR001408
PDB; 1TND
SCOP; 1TND
Literature References
1. LINDER, M.E. AND GILMAN, A.G.
G proteins.
SCI.AM. 267 56 (1992).
 
2. KAZIRO, Y., ITOH, H., KOZASA, T., NAKAFUKU, M. AND SATOH, T.
Structure and function of signal-transducing GTP-binding proteins.
ANNU.REV.BIOCHEMISTRY 60 349-400 (1991).
 
3. SIMON, M.I., STRATHMANN, M.P. AND GAUTAM, N.
Diversity of G proteins in signal transduction.
SCIENCE 252 802-808 (1993).

Documentation
Guanine nucleotide binding proteins (G proteins) are a family of membrane-
associated proteins that couple extracellularly-activated integral-membrane
receptors to intracellular effectors, such as ion channels and enzymes that
vary the concentration of second messenger molecules [1-3]. G proteins are
composed of 3 subunits (alpha, beta and gamma) which, in the resting state,
associate as a trimer at the inner face of the plasma membrane. The alpha
subunit has a molecule of guanosine diphosphate (GDP) bound to it:
stimulation of the G protein by an activated receptor leads to its exchange
for GTP (guanosine triphosphate). This results in the separation of the
alpha from the beta and gamma subunits, which always remain tightly
associated as a dimer. Both the alpha and beta-gamma subunits are then able
to interact with effectors, either individually or in a cooperative manner.
The intrinsic GTPase activity of the alpha subunit hydrolyses the bound GTP
to GDP. This returns the alpha subunit to its inactive conformation and
allows it to reassociate with the beta-gamma subunit, thus restoring the
system to its resting state.
 
G protein alpha subunits are 350-400 amino acids in length and have
molecular weights in the range 40-45 kDa. Seventeen distinct types of alpha
subunit have been identified in mammals. These fall into 4 main  groups on
the basis of both sequence similarity and function: alpha-S, alpha-Q,
alpha-I and alpha-12 [3]. Many alpha subunits are substrates for
ADP-ribosylation by cholera or pertussis toxins. They are often N-terminally
acylated, usually with myristate and/or palmitoylate, and these fatty acid
modifications are probably important for membrane association and high-
affinity interactions with other proteins. The atomic structure of the alpha
subunit of the G protein involved in mammalian vision, transducin, has been
elucidated in both GTP- and GDB-bound forms, and shows considerable
similarity in both primary and tertiary structure in the nucleotide-binding
regions to other G proteins, such as p21-ras and EF-Tu.
 
The G protein alpha-I (G alpha-I) class can be divided into alpha-I-like,
alpha-O-like, alpha-T-like and alpha-Z-like. The alpha-I-like proteins were
originally identified as the proteins responsible for receptor-mediated
inhibition of adenylyl cyclase, hence `I' for inhibitory. Alpha-O is an
extremely abundant G protein that is expressed predominantly in the brain,
where it is known to couple receptors such as the M2 acetylcholine receptor
to neuronal potassium and calcium channels, and has been implicated in
membrane trafficking.
 
Alpha-T, transducin, is the G protein responsible for transducing the light
response in vertebrate retinae. It is activated by rhodopsin or cone opsin,
and in turn activates the effector enzyme cyclic guanine monophosphate
phosphodiesterase (cGMP-PDE). The resultant lowering of GDP levels causes
cGMP-gated sodium channels to close, and the subsequent hyperpolarisation
of the cell membrane leads to the generation of a nervous impulse. Alpha-Z
is a relatively unknown protein showing significant divergence by comparison
with conserved regions of other alpha subunits.
 
GPROTEINAI is a 5-element fingerprint that provides a signature for the
G protein alpha subunit group I. The fingerprint was derived from an initial
alignment of 13 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length, focusing on those sections 
that characterise group I alpha subunits but distinguish them from other
G protein alpha subtypes. Three iterations on SPTR37_10f were required to
reach convergence, at which point a true set comprising 57 sequences was
identified. Three partial matches were also found: Q21917 and O44409 are
C.elegans proteins that share significant similarity with the alpha-I 
proteins; GBA2_DICDI is an alpha subunit from the slime mold D.discoideum.
Summary Information
  57 codes involving  5 elements
0 codes involving 4 elements
1 codes involving 3 elements
2 codes involving 2 elements
Composite Feature Index
55757575757
400000
310101
210210
12345
True Positives
GB01_BOVIN    GB01_DROME    GB01_HUMAN    GB01_MOUSE    
GB01_RAT GB02_CRILO GB02_DROME GB02_HUMAN
GB02_MOUSE GB02_RAT GB05_DROME GB0_CAEEL
GB0_HELTI GB0_LOCMI GB0_LYMST GB0_MANSE
GB0_PATYE GB0_XENLA GBAK_CAVPO GBAK_HUMAN
GBAK_RAT GBAZ_HUMAN GBAZ_RAT GBI1_CAVPO
GBI1_CHICK GBI1_HUMAN GBI1_ORYLA GBI1_RAT
GBI1_XENLA GBI2_CANFA GBI2_CAVPO GBI2_CHICK
GBI2_HUMAN GBI2_MOUSE GBI2_RAT GBI_ASTPE
GBI_HELTI GBI_HOMAM GBI_LYMST GBT1_BOVIN
GBT1_CANFA GBT1_HUMAN GBT1_MOUSE GBT2_BOVIN
GBT2_HUMAN GBT2_MOUSE GBT3_RAT GBT_XENLA
O13011 O13055 O93564 P79895
Q18205 Q90846 Q90847 Q9YI22
Q9YI23
True Positive Partials
Codes involving 3 elements
Q21917
Codes involving 2 elements
GBA2_DICDI O44409
Sequence Titles
GB01_BOVIN  GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT 1 (GTP-BINDING PROTEIN G3 
GB01_DROME GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT (G(O) CLASS-I) - DROSOPHI
GB01_HUMAN GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT 1 - HOMO SAPIENS (HUMAN).
GB01_MOUSE GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT 1 - MUS MUSCULUS (MOUSE).
GB01_RAT GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT 1 - RATTUS NORVEGICUS (RA
GB02_CRILO GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT 2 - CRICETULUS LONGICAUDA
GB02_DROME GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT (G(O) CLASS- II) - DROSOP
GB02_HUMAN GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT 2 - HOMO SAPIENS (HUMAN).
GB02_MOUSE GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT 2 - MUS MUSCULUS (MOUSE).
GB02_RAT GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT 2 - RATTUS NORVEGICUS (RA
GB05_DROME GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT - DROSOPHILA MELANOGASTER
GB0_CAEEL GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT - CAENORHABDITIS ELEGANS.
GB0_HELTI GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT - HELISOMA TRIVOLVIS (SNA
GB0_LOCMI GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT - LOCUSTA MIGRATORIA (MIG
GB0_LYMST GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT - LYMNAEA STAGNALIS (GREA
GB0_MANSE GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT - MANDUCA SEXTA (TOBACCO
GB0_PATYE GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT - PATINOPECTEN YESSOENSIS
GB0_XENLA GUANINE NUCLEOTIDE-BINDING PROTEIN G(O), ALPHA SUBUNIT - XENOPUS LAEVIS (AFRICAN
GBAK_CAVPO GUANINE NUCLEOTIDE-BINDING PROTEIN G(K), ALPHA SUBUNIT (G(I) ALPHA-3) - CAVIA PO
GBAK_HUMAN GUANINE NUCLEOTIDE-BINDING PROTEIN G(K), ALPHA SUBUNIT (G(I) ALPHA-3) - HOMO SAP
GBAK_RAT GUANINE NUCLEOTIDE-BINDING PROTEIN G(K), ALPHA SUBUNIT (G(I) ALPHA-3) - RATTUS N
GBAZ_HUMAN GUANINE NUCLEOTIDE-BINDING PROTEIN G(Z), ALPHA SUBUNIT (G(X) ALPHA CHAIN) - HOMO
GBAZ_RAT GUANINE NUCLEOTIDE-BINDING PROTEIN G(Z), ALPHA SUBUNIT (G(X) ALPHA CHAIN) - RATT
GBI1_CAVPO GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT (ADENYLATE CYCLASE-INHI
GBI1_CHICK GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT (ADENYLATE CYCLASE-INHI
GBI1_HUMAN GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT (ADENYLATE CYCLASE-INHI
GBI1_ORYLA GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT (ADENYLATE CYCLASE-INHI
GBI1_RAT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT (ADENYLATE CYCLASE-INHI
GBI1_XENLA GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT (ADENYLATE CYCLASE-INHI
GBI2_CANFA GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-2 SUBUNIT (ADENYLATE CYCLASE-INHI
GBI2_CAVPO GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-2 SUBUNIT (ADENYLATE CYCLASE-INHI
GBI2_CHICK GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-2 SUBUNIT (ADENYLATE CYCLASE-INHI
GBI2_HUMAN GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-2 SUBUNIT (ADENYLATE CYCLASE-INHI
GBI2_MOUSE GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-2 SUBUNIT (ADENYLATE CYCLASE-INHI
GBI2_RAT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-2 SUBUNIT (ADENYLATE CYCLASE-INHI
GBI_ASTPE GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA SUBUNIT (ADENYLATE CYCLASE-INHIBI
GBI_HELTI GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA SUBUNIT (ADENYLATE CYCLASE-INHIBI
GBI_HOMAM GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA SUBUNIT (ADENYLATE CYCLASE-INHIBI
GBI_LYMST GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA SUBUNIT (ADENYLATE CYCLASE-INHIBI
GBT1_BOVIN GUANINE NUCLEOTIDE-BINDING PROTEIN G(T), ALPHA-1 SUBUNIT (TRANSDUCIN ALPHA-1 CHA
GBT1_CANFA GUANINE NUCLEOTIDE-BINDING PROTEIN G(T), ALPHA-1 SUBUNIT (TRANSDUCIN ALPHA-1 CHA
GBT1_HUMAN GUANINE NUCLEOTIDE-BINDING PROTEIN G(T), ALPHA-1 SUBUNIT (TRANSDUCIN ALPHA-1 CHA
GBT1_MOUSE GUANINE NUCLEOTIDE-BINDING PROTEIN G(T), ALPHA-1 SUBUNIT (TRANSDUCIN ALPHA-1 CHA
GBT2_BOVIN GUANINE NUCLEOTIDE-BINDING PROTEIN G(T), ALPHA-2 SUBUNIT (TRANSDUCIN ALPHA-2 CHA
GBT2_HUMAN GUANINE NUCLEOTIDE-BINDING PROTEIN G(T), ALPHA-2 SUBUNIT (TRANSDUCIN ALPHA-2 CHA
GBT2_MOUSE GUANINE NUCLEOTIDE-BINDING PROTEIN G(T), ALPHA-2 SUBUNIT (TRANSDUCIN ALPHA-2 CHA
GBT3_RAT GUANINE NUCLEOTIDE-BINDING PROTEIN G(T), ALPHA-3 SUBUNIT (GUSTDUCIN ALPHA-3 CHAI
GBT_XENLA GUANINE NUCLEOTIDE-BINDING PROTEIN G(T), ALPHA SUBUNIT (TRANSDUCIN ALPHA CHAIN)
O13011 ALPHA 01 SUBUNIT OF HETEROTRIMERIC GTP-BINDING PROTEIN - XENOPUS LAEVIS (AFRICAN
O13055 GI2 ALPHA SUBUNIT - ORYZIAS LATIPES (MEDAKA FISH).
O93564 GUANINE NUCLEOTIDE-BINDING PROTEIN G(O) ALPHA SUBUNIT 1 - XENOPUS LAEVIS (AFRICA
P79895 TRANSDUCIN ALPHA SUBUNIT - SPARUS AURATA (GILTHEAD SEA BREAM).
Q18205 GOA-1 PROTEIN - CAENORHABDITIS ELEGANS.
Q90846 G PROTEIN - GALLUS GALLUS (CHICKEN).
Q90847 G PROTEIN ALPHA SUBUNIT - GALLUS GALLUS (CHICKEN).
Q9YI22 CONE TRANSDUCIN ALPHA SUBUNIT - AMBYSTOMA TIGRINUM (TIGER SALAMANDER).
Q9YI23 ROD TRANSDUCIN ALPHA SUBUNIT - AMBYSTOMA TIGRINUM (TIGER SALAMANDER).

Q21917 GPA-7 PROTEIN - CAENORHABDITIS ELEGANS.

GBA2_DICDI GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT (G ALPHA 2) - DICTYOSTELIUM D
O44409 T07A9.7 PROTEIN - CAENORHABDITIS ELEGANS.
Scan History
SPTR37_10f 3  70   NSINGLE    
Initial Motifs
Motif 1  width=10
Element Seqn Id St Int Rpt
QSMIAIIKAM GBI_LYMST 78 78 -
QSLAAIVRAM GB01_RAT 78 78 -
QSIIAIIRAM GBAK_CAVPO 78 78 -
QSIMAIVKAM GBI2_CANFA 78 78 -
QSLVAILRAM GB0_LOCMI 79 79 -
QSLVAILRAM GB0_CAEEL 78 78 -
QSLVAILRAM GB02_DROME 79 79 -
QSLAAIVRAM GB02_HUMAN 78 78 -
QSILAIVRAM GBT1_HUMAN 74 74 -
QSILAIIRAM GBT2_BOVIN 78 78 -
QSLMVIIRAM GB05_DROME 80 80 -
QSILAIVKAM GBT3_RAT 78 78 -
DSLTRIIRAL GBAZ_HUMAN 79 79 -

Motif 2 width=11
Element Seqn Id St Int Rpt
VETHFTFKDLH GBI_LYMST 184 96 -
VETHFTFKNLH GB01_RAT 185 97 -
VETHFTFKDLY GBAK_CAVPO 184 96 -
VETHFTFKDLH GBI2_CANFA 185 97 -
VEVHFSFKNLN GB0_LOCMI 186 97 -
VEVHFTFKNLN GB0_CAEEL 185 97 -
VEVHFSFKNLN GB02_DROME 186 97 -
VETHFTFKNLH GB02_HUMAN 185 97 -
IETQFSFKDLN GBT1_HUMAN 180 96 -
IETKFSVKDLN GBT2_BOVIN 184 96 -
IETHFSCKQLH GB05_DROME 186 96 -
IETQFSFKDLN GBT3_RAT 184 96 -
VENKFTFKELT GBAZ_HUMAN 186 97 -

Motif 3 width=13
Element Seqn Id St Int Rpt
IKKSPLTICFPEY GBI_LYMST 277 82 -
IKKSPLTICFPEY GB01_RAT 278 82 -
IKRSPLTICYPEY GBAK_CAVPO 277 82 -
ITHSPLTICFPEY GBI2_CANFA 278 82 -
IKKSPLTICFPEY GB0_LOCMI 279 82 -
IKKSPLTICFPEY GB0_CAEEL 278 82 -
IRKSPLTICFPEY GB02_DROME 279 82 -
IKKSPLTICFPEY GB02_HUMAN 278 82 -
IKKAHLSICFPDY GBT1_HUMAN 273 82 -
IKKVHLSICFPEY GBT2_BOVIN 277 82 -
IKRSPLTICFPEY GB05_DROME 279 82 -
VTKVHLSICFPEY GBT3_RAT 277 82 -
IRRIPLTICFPEY GBAZ_HUMAN 279 82 -

Motif 4 width=12
Element Seqn Id St Int Rpt
YEEAAAYIQLQF GBI_LYMST 295 5 -
YEDAAAYIQTQF GB01_RAT 296 5 -
YEEAAAYIQCQF GBAK_CAVPO 295 5 -
YEEAASYIQSKF GBI2_CANFA 296 5 -
YGEAAAYIQAQF GB0_LOCMI 297 5 -
YHEASAYIQAQF GB0_CAEEL 296 5 -
YGEAAAYIQAQF GB02_DROME 297 5 -
FTEAVAYIQAQY GB02_HUMAN 296 5 -
YEDAGNYIKVQF GBT1_HUMAN 291 5 -
YEDAGNYIKSQF GBT2_BOVIN 295 5 -
FEEAANYIRMKF GB05_DROME 297 5 -
FEDAGNYIKNQF GBT3_RAT 295 5 -
YEEAAVYIQRQF GBAZ_HUMAN 297 5 -

Motif 5 width=12
Element Seqn Id St Int Rpt
IIKNNLKDCGLF GBI_LYMST 342 35 -
IIANNLRGCGLY GB01_RAT 342 34 -
IIKNNLKECGLY GBAK_CAVPO 342 35 -
IIKNNLKDCGLF GBI2_CANFA 343 35 -
IIANNLRGCGLY GB0_LOCMI 343 34 -
IIANNLRGCGLY GB0_CAEEL 342 34 -
IIANNLRGCGLY GB02_DROME 343 34 -
IIAKNLRGCGLY GB02_HUMAN 342 34 -
IIKENLKDCGLF GBT1_HUMAN 338 35 -
IIKENLKDCGLF GBT2_BOVIN 342 35 -
IIKNNLKQIGLF GB05_DROME 344 35 -
IIKENLKDCGLF GBT3_RAT 342 35 -
IIQNNLKYIGLC GBAZ_HUMAN 344 35 -
Final Motifs
Motif 1  width=10
Element Seqn Id St Int Rpt
QSIIAIIRAM GBI1_CAVPO 78 78 -
QSIIAIIRAM GBI1_RAT 78 78 -
QSIIAIIRAM GBI1_HUMAN 78 78 -
QSIIAIIRAM GBI1_CHICK 78 78 -
QSIIAIIRAM GBI1_XENLA 78 78 -
QSMIAIIRAM GBI_ASTPE 78 78 -
QSMIAIIKAM GBI_HELTI 78 78 -
QSMIAIIKAM GBI_LYMST 78 78 -
QSLAAIVRAM GB01_BOVIN 78 78 -
QSLAAIVRAM GB01_HUMAN 78 78 -
QSIIAIIRAM Q90846 79 79 -
QSIIAIIRAM Q90847 79 79 -
QSIIAIIRAM GBI1_ORYLA 78 78 -
QSLAAIVRAM GB01_MOUSE 78 78 -
QSLAAIVRAM GB01_RAT 78 78 -
QSLAAIVRAM O13011 79 79 -
QSIIAIIRAM GBAK_CAVPO 78 78 -
QSIIAIIRAM GBAK_HUMAN 78 78 -
QSIIAIIRAM GBAK_RAT 78 78 -
QSIMAIVKAM GBI2_CANFA 78 78 -
QSLVAILRAM GB0_LOCMI 79 79 -
QSLAAIVRAM O93564 79 79 -
QSLVAIIRAM GB0_HELTI 78 78 -
QSLVAIIRAM GB0_LYMST 78 78 -
QSLVAILRAM GB0_CAEEL 78 78 -
QSLVAILRAM Q18205 79 79 -
QSLVAIVRAM GB0_PATYE 78 78 -
QSIMAIVKAM GBI2_CAVPO 78 78 -
QSIMAIVKAM GBI2_HUMAN 78 78 -
QSIMAIVKAM GBI2_RAT 78 78 -
QSLVAILRAM GB01_DROME 79 79 -
QSLVAILRAM GB02_DROME 79 79 -
QSIMAIIKAM GBI2_CHICK 78 78 -
QSIMAIIKAM O13055 79 79 -
QSILAIVKAM GBI2_MOUSE 78 78 -
QSLAAIVRAM GB02_HUMAN 78 78 -
QSLVAILRAM GB0_MANSE 78 78 -
QSLMAIIRAM GBI_HOMAM 79 79 -
QSLAAIVRAM GB02_MOUSE 78 78 -
QSLAAIVRAM GB02_RAT 78 78 -
QSILAIVRAM GBT1_BOVIN 74 74 -
QSILAIVRAM GBT1_MOUSE 74 74 -
QSILAIVRAM GBT1_HUMAN 74 74 -
QSILAIVRAM GBT1_CANFA 74 74 -
QSILAIIRAM GBT2_BOVIN 78 78 -
QSILAIIRAM GBT2_MOUSE 78 78 -
QSLAAIVRAM GB02_CRILO 78 78 -
QSILAIIRAM GBT2_HUMAN 78 78 -
QSLAAIVRAM GB0_XENLA 78 78 -
QSMLAIVRAM Q9YI23 75 75 -
QSLMVIIRAM GB05_DROME 80 80 -
QSILAIVKAM GBT3_RAT 78 78 -
QSMIAIVKAM GBT_XENLA 74 74 -
QSILSIIRAM Q9YI22 79 79 -
QSALAIIRGM P79895 75 75 -
DSLTRIIRAL GBAZ_HUMAN 79 79 -
DSLTRIIRAL GBAZ_RAT 79 79 -

Motif 2 width=11
Element Seqn Id St Int Rpt
VETHFTFKDLH GBI1_CAVPO 184 96 -
VETHFTFKDLH GBI1_RAT 184 96 -
VETHFTFKDLH GBI1_HUMAN 184 96 -
VETHFTFKDLH GBI1_CHICK 184 96 -
VETHFTFKDLH GBI1_XENLA 184 96 -
VETHFTFKDLH GBI_ASTPE 184 96 -
VETHFTFKDLH GBI_HELTI 184 96 -
VETHFTFKDLH GBI_LYMST 184 96 -
VETHFTFKNLH GB01_BOVIN 185 97 -
VETHFTFKNLH GB01_HUMAN 185 97 -
VETHFTFKDLY Q90846 185 96 -
VETHFTFKDLY Q90847 185 96 -
VETHFTFKDLH GBI1_ORYLA 184 96 -
VETHFTFKNLH GB01_MOUSE 185 97 -
VETHFTFKNLH GB01_RAT 185 97 -
VETHFTFKNLH O13011 186 97 -
VETHFTFKDLY GBAK_CAVPO 184 96 -
VETHFTFKDLY GBAK_HUMAN 184 96 -
VETHFTFKELY GBAK_RAT 184 96 -
VETHFTFKDLH GBI2_CANFA 185 97 -
VEVHFSFKNLN GB0_LOCMI 186 97 -
VETHFTFKNLH O93564 186 97 -
VEVHFSFKNLN GB0_HELTI 185 97 -
VEVHFSFKNLN GB0_LYMST 185 97 -
VEVHFTFKNLN GB0_CAEEL 185 97 -
VEVHFTFKNLN Q18205 186 97 -
VEVHFSFKNLN GB0_PATYE 188 100 -
VETHFTFKDLH GBI2_CAVPO 185 97 -
VETHFTFKDLH GBI2_HUMAN 185 97 -
VETHFTFKDLH GBI2_RAT 185 97 -
VEVHFSFKNLN GB01_DROME 186 97 -
VEVHFSFKNLN GB02_DROME 186 97 -
VETHFTFKDLH GBI2_CHICK 185 97 -
VETHFTFKDLH O13055 186 97 -
VETHFTFKDLH GBI2_MOUSE 185 97 -
VETHFTFKNLH GB02_HUMAN 185 97 -
VEVHFSFKNLN GB0_MANSE 185 97 -
VETNFSFKNLN GBI_HOMAM 185 96 -
VETHFTFKNLH GB02_MOUSE 185 97 -
VETHFTFKNLH GB02_RAT 185 97 -
IETQFSFKDLN GBT1_BOVIN 180 96 -
IETQFSFKDLN GBT1_MOUSE 180 96 -
IETQFSFKDLN GBT1_HUMAN 180 96 -
IETQFSFKDLN GBT1_CANFA 180 96 -
IETKFSVKDLN GBT2_BOVIN 184 96 -
IETKFSVKDLN GBT2_MOUSE 184 96 -
VETHFTFKNLH GB02_CRILO 185 97 -
IETKFSVKDLN GBT2_HUMAN 184 96 -
VETHFTFKNLH GB0_XENLA 185 97 -
IETQFGLKDLN Q9YI23 181 96 -
IETHFSCKQLH GB05_DROME 186 96 -
IETQFSFKDLN GBT3_RAT 184 96 -
IETQFGLKDLN GBT_XENLA 180 96 -
IETQFSFKDLH Q9YI22 185 96 -
IEEQFSCKELH P79895 181 96 -
VENKFTFKELT GBAZ_HUMAN 186 97 -
VENKFTFKELT GBAZ_RAT 186 97 -

Motif 3 width=13
Element Seqn Id St Int Rpt
IKKSPLTICYPEY GBI1_CAVPO 277 82 -
IKKSPLTICYPEY GBI1_RAT 277 82 -
IKKSPLTICYPEY GBI1_HUMAN 277 82 -
IKRSPLTICYPEY GBI1_CHICK 277 82 -
IKRSPLTICYPEY GBI1_XENLA 277 82 -
ITKSPLTICFPEY GBI_ASTPE 277 82 -
IKKSPLTICFPEY GBI_HELTI 277 82 -
IKKSPLTICFPEY GBI_LYMST 277 82 -
IKKSPLTICFPEY GB01_BOVIN 278 82 -
IKKSPLTICFPEY GB01_HUMAN 278 82 -
IKKSPLTICYPEY Q90846 278 82 -
IKKSPLTICYPEY Q90847 278 82 -
IKKSLLTICFPEY GBI1_ORYLA 277 82 -
IKKSPLTICFPEY GB01_MOUSE 278 82 -
IKKSPLTICFPEY GB01_RAT 278 82 -
IKKSPLSICFPEY O13011 279 82 -
IKRSPLTICYPEY GBAK_CAVPO 277 82 -
IKRSPLTICYPEY GBAK_HUMAN 277 82 -
IKRSPLTICYPEY GBAK_RAT 277 82 -
ITHSPLTICFPEY GBI2_CANFA 278 82 -
IKKSPLTICFPEY GB0_LOCMI 279 82 -
IKKSPLSICFPEY O93564 279 82 -
IKKSPLTICFPEY GB0_HELTI 278 82 -
IKKSPLTICFPEY GB0_LYMST 278 82 -
IKKSPLTICFPEY GB0_CAEEL 278 82 -
IKKSPLTICFPEY Q18205 279 82 -
IKKSSLTICFNEY GB0_PATYE 281 82 -
ITHSPLTICFPEY GBI2_CAVPO 278 82 -
ITHSPLTICFPEY GBI2_HUMAN 278 82 -
ITQSPLTICFPEY GBI2_RAT 278 82 -
IRKSPLTICFPEY GB01_DROME 279 82 -
IRKSPLTICFPEY GB02_DROME 279 82 -
IVHSPLTICFPEY GBI2_CHICK 278 82 -
IAHSPLTICFPEY O13055 279 82 -
ITQSSLTICFPEY GBI2_MOUSE 278 82 -
IKKSPLTICFPEY GB02_HUMAN 278 82 -
IRKSPLTICFPEY GB0_MANSE 279 83 -
ITKSPLTICFPEY GBI_HOMAM 278 82 -
IKKSPLTICFPEY GB02_MOUSE 278 82 -
IKKSPLTICFPEY GB02_RAT 278 82 -
IKKAHLSICFPDY GBT1_BOVIN 273 82 -
IKKAHLSICFPDY GBT1_MOUSE 273 82 -
IKKAHLSICFPDY GBT1_HUMAN 273 82 -
IKKAHLSICFPDY GBT1_CANFA 273 82 -
IKKVHLSICFPEY GBT2_BOVIN 277 82 -
IKKVHLSICFPEY GBT2_MOUSE 277 82 -
ITRSPLTICFPEY GB02_CRILO 278 82 -
IKKVHLSICFPEY GBT2_HUMAN 277 82 -
IKSSPLTICFPEY GB0_XENLA 278 82 -
IKKAHLSICFPDY Q9YI23 274 82 -
IKRSPLTICFPEY GB05_DROME 279 82 -
VTKVHLSICFPEY GBT3_RAT 277 82 -
IKKAHLSICFPDY GBT_XENLA 273 82 -
IKKVHLSICFPDY Q9YI22 278 82 -
IKKVHLSICFPDY P79895 274 82 -
IRRIPLTICFPEY GBAZ_HUMAN 279 82 -
IRRIPLSVCFPEY GBAZ_RAT 279 82 -

Motif 4 width=12
Element Seqn Id St Int Rpt
YEEAAAYIQCQF GBI1_CAVPO 295 5 -
YEEAAAYIQCQF GBI1_RAT 295 5 -
YEEAAAYIQCQF GBI1_HUMAN 295 5 -
YEEAAAYIQCQF GBI1_CHICK 295 5 -
YEEAAAYIQCQF GBI1_XENLA 295 5 -
YEEAAAYIQMQF GBI_ASTPE 295 5 -
YEEAAAYIQLQF GBI_HELTI 295 5 -
YEEAAAYIQLQF GBI_LYMST 295 5 -
YEDAAAYIQAQF GB01_BOVIN 296 5 -
YEDAAAYIQAQF GB01_HUMAN 296 5 -
YEEAAAYIQCQF Q90846 296 5 -
YEEAAAYIQCQF Q90847 296 5 -
YEEAAAYVQCQF GBI1_ORYLA 295 5 -
YEDAAAYIQTQF GB01_MOUSE 296 5 -
YEDAAAYIQTQF GB01_RAT 296 5 -
YEDAAAYIQAQF O13011 297 5 -
YEEAAAYIQCQF GBAK_CAVPO 295 5 -
YEEAAAYIQCQF GBAK_HUMAN 295 5 -
YEEAAAYIQCQF GBAK_RAT 295 5 -
YEEAASYIQSKF GBI2_CANFA 296 5 -
YGEAAAYIQAQF GB0_LOCMI 297 5 -
YEDAAAYIQAQF O93564 297 5 -
YQEASAYIQAQF GB0_HELTI 296 5 -
YQEASAYIQAQF GB0_LYMST 296 5 -
YHEASAYIQAQF GB0_CAEEL 296 5 -
YHEASAYIQAQF Q18205 297 5 -
YEEAAAYIQAQF GB0_PATYE 299 5 -
YDEAASYIQSKF GBI2_CAVPO 296 5 -
YDEAASYIQSKF GBI2_HUMAN 296 5 -
YDEAASYIQSKF GBI2_RAT 296 5 -
YGEAAAYIQAQF GB01_DROME 297 5 -
YGEAAAYIQAQF GB02_DROME 297 5 -
YDEAAGYIQSKF GBI2_CHICK 296 5 -
YQEAQAYIQTKF O13055 297 5 -
YDEAASYIQSKF GBI2_MOUSE 296 5 -
FTEAVAYIQAQY GB02_HUMAN 296 5 -
YGEAAAYIRSQF GB0_MANSE 298 6 -
YEDSANYIRMKF GBI_HOMAM 296 5 -
FTEAVAHIQGQY GB02_MOUSE 296 5 -
FTEAVAHIQGQY GB02_RAT 296 5 -
YEDAGNYIKVQF GBT1_BOVIN 291 5 -
YEDAGNYIKVQF GBT1_MOUSE 291 5 -
YEDAGNYIKVQF GBT1_HUMAN 291 5 -
YEDAGNYIKVQF GBT1_CANFA 291 5 -
YEDAGNYIKSQF GBT2_BOVIN 295 5 -
YEDAGNYIKSQF GBT2_MOUSE 295 5 -
FTEAVAHIQGQY GB02_CRILO 296 5 -
YDDAGNYIKSQF GBT2_HUMAN 295 5 -
FTEAVAHTQHQY GB0_XENLA 296 5 -
YEDAGNYIKQQF Q9YI23 292 5 -
FEEAANYIRMKF GB05_DROME 297 5 -
FEDAGNYIKNQF GBT3_RAT 295 5 -
YEDAGNYIKTQF GBT_XENLA 291 5 -
YDDAANYIKLQF Q9YI22 296 5 -
YEDASNYIKAQF P79895 292 5 -
YEEAAVYIQRQF GBAZ_HUMAN 297 5 -
YEEAAVYIQRQF GBAZ_RAT 297 5 -

Motif 5 width=12
Element Seqn Id St Int Rpt
IIKNNLKDCGLF GBI1_CAVPO 342 35 -
IIKNNLKDCGLF GBI1_RAT 342 35 -
IIKNNLKDCGLF GBI1_HUMAN 342 35 -
IIKNNLKDCGLF GBI1_CHICK 342 35 -
IIKNNLKDCGLF GBI1_XENLA 342 35 -
IIKNNLKDCGLF GBI_ASTPE 342 35 -
IIKNNLKDCGLF GBI_HELTI 342 35 -
IIKNNLKDCGLF GBI_LYMST 342 35 -
IIANNLRGCGLY GB01_BOVIN 342 34 -
IIANNLRGCGLY GB01_HUMAN 342 34 -
IIKNNLKECGLY Q90846 343 35 -
IIKNNLKECGLY Q90847 343 35 -
IIKNNLKDCGLF GBI1_ORYLA 342 35 -
IIANNLRGCGLY GB01_MOUSE 342 34 -
IIANNLRGCGLY GB01_RAT 342 34 -
IIANNLRGCGLY O13011 343 34 -
IIKNNLKECGLY GBAK_CAVPO 342 35 -
IIKNNLKECGLY GBAK_HUMAN 342 35 -
IIKNNLKECGLY GBAK_RAT 342 35 -
IIKNNLKDCGLF GBI2_CANFA 343 35 -
IIANNLRGCGLY GB0_LOCMI 343 34 -
IIATTLRGCGLY O93564 343 34 -
IIANNLRGCGLY GB0_HELTI 342 34 -
IIANNLRGCGLY GB0_LYMST 342 34 -
IIANNLRGCGLY GB0_CAEEL 342 34 -
IIANNLRGCGLY Q18205 343 34 -
IIANNLRGCGLY GB0_PATYE 345 34 -
IIKNNLKDCGLF GBI2_CAVPO 343 35 -
IIKNNLKDCGLF GBI2_HUMAN 343 35 -
IIKNNLKDCGLF GBI2_RAT 343 35 -
IIANNLRGCGLY GB01_DROME 343 34 -
IIANNLRGCGLY GB02_DROME 343 34 -
IIKNNLKDCGLF GBI2_CHICK 343 35 -
IIKNNLKDCGLF O13055 344 35 -
IIKNNLKDCGLF GBI2_MOUSE 343 35 -
IIAKNLRGCGLY GB02_HUMAN 342 34 -
IIANNLRGCGLY GB0_MANSE 343 33 -
IIKNNLKDCGLF GBI_HOMAM 343 35 -
IIAKNLRGCGLY GB02_MOUSE 342 34 -
IIAKNLRGCGLY GB02_RAT 342 34 -
IIKENLKDCGLF GBT1_BOVIN 338 35 -
IIKENLKDCGLF GBT1_MOUSE 338 35 -
IIKENLKDCGLF GBT1_HUMAN 338 35 -
IIKENLKDCGLF GBT1_CANFA 338 35 -
IIKENLKDCGLF GBT2_BOVIN 342 35 -
IIKENLKDCGLF GBT2_MOUSE 342 35 -
IIAKNLRGCGLY GB02_CRILO 342 34 -
IIKENLKDCGLF GBT2_HUMAN 342 35 -
IIAYNLRGCGLY GB0_XENLA 342 34 -
IIKENLKDCGLF Q9YI23 339 35 -
IIKNNLKQIGLF GB05_DROME 344 35 -
IIKENLKDCGLF GBT3_RAT 342 35 -
IIKENLKDCGLF GBT_XENLA 338 35 -
VIKETLKDCGLF Q9YI22 343 35 -
IIKENLKDCGLF P79895 339 35 -
IIQNNLKYIGLC GBAZ_HUMAN 344 35 -
IIQNNLKYIGLC GBAZ_RAT 344 35 -