| Literature References | 1. OLLIS, D.L., CHEAH, E., CYGLER, M., DIJKSTRA, B., FROLOW, F., FRANKEN,
S.M., HAREL, M., REMINGTON, S.J., SILMAN, I., SCHRAG, J., SUSSMAN, J.L.,
VERSCHUEREN, K.H.G. AND GOLDMAN, A.
The alpha/beta hydrolase fold.
PROTEIN ENG. 5(3) 197-211 (1992).
2. BEETHAM, J.K., GRANT, D.F., ARAND, M., GARBARINO, J., KIYOSUE, T.,
PINOT, F., OESCH, F., BELKNAP, W.R., SHINOZAKI, K. AND HAMMOCK, B.D.
Gene evolution of epoxide hydrolases and recommended nomenclature.
DNA CELL BIOL. 14(1) 61-71 (1995).
3. FRANKEN, S.M., ROZEBOOM, H.J., KALK, K.H. AND DIJKSTRA, B.W.
Crystal structure of haloalkane dehalogenase: an enzyme to detoxify
halogenated alkanes.
EMBO J. 10 1297-1302 (1991).
4. VERSCHUEREN, K.H.G., SELJEE, F., ROZEBOOM, H.J., KALK, K.H. AND
DIJKSTRA, B.W.
Crystallographic analysis of the catalytic mechanism of haloalkane
dehalogenase.
NATURE 363 693-698 (1993).
5. PINOT, F., GRANT, D.F., BEETHAM, J.K., PARKER, A.G., BORHAN, B.,
LANDT, S., JONES, A.D. AND HAMMOCK, B.D.
Molecular and biochemical evidence for the involvement of the Asp-333-
His-523 pair in the catalytic mechanism of soluble epoxide hydrolase.
J.BIOL.CHEM. 270 7968-7974 (1995).
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| Documentation | The alpha/beta hydrolase fold is common to a number of hydrolytic enzymes
of widely differing phylogenetic origin and catalytic function. The core
of each enzyme is an alpha/beta-sheet (rather than a barrel), containing 8
strands connected by helices [1]. The enzymes are believed to have diverged
from a common ancestor, preserving the arrangement of the catalytic
residues. All have a catalytic triad, the elements of which are borne on
loops, which are the best conserved structural features of the fold.
The epoxide hydrolases (EH) add water to epoxides, forming the corresponding
diol. On the basis of sequence similarity, it has been proposed that the
mammalian soluble EHs contain 2 evolutionarily distinct domains [2]: the
N-terminal domain is similar to bacterial haloacid dehalogenase; while the
C-terminal domain is similar to soluble plant EH, microsomal EH, and
bacterial haloalkane dehalogenase (HLD).
The crystal structure of HLD has been resolved to 1.9A [3]. The enzyme
contains 2 domains: domain I, has an alpha/beta type structure with a
central 8-stranded beta-sheet, and contains the nucleophile-acid-His
catalytic triad; in the linear sequence, domain I is interrupted by domain
II (residues 156-229), which consists of alpha-helices connected by loops,
and is responsible for substrate binding and specificity. The similarity of
EH to HLD is important for deducing a catalytic mechanism for EH. The
mechanism of HLD, established by X-ray crystallographic analysis of an
HDL-substrate intermediate [4], involves nucleophilic attack of Asp-124 on
the halogen-substituted terminal carbon of the substrate, forming a
covalently-bound ester intermediate. The Asp-260/His-289 pair activate a
water molecule that hydrolyses the ester intermediate to release the
product. Mutagenesis experiments on murine soluble EH confirmed the crucial
role of nucleophile Asp-333 and His-523 in the catalytic mechanism and
the importance of conserved His-263 and His-332 [5].
EPOXHYDRLASE is a 6-element fingerprint that provides a signature for the
epoxide hydrolase family. The fingerprint was derived from an initial
alignment of 9 sequences: the motifs were drawn from conserved regions
within domain I - motif 1 contains highly conserved residues that are
putatively involved in forming an oxyanion hole, which stabilises an
enzyme-substrate tetrahedral intermediate [1,4]; motif 3 includes an
invariant Asn (Asp-124 in HDL); motifs 5 and 6 contain a conserved
acidic residue and an invariant His, respectively, corresponding to the
Asp-260/His-289 pair of HDL (motifs 2-5 correspond to ABHYDROLASE motifs
1-4). Two iterations on OWL26.0 were required to reach convergence, at
which point a true set comprising 16 sequences was identified. Several
partial matches were also found, most of which are hydrolases. The epoxide
hydrolase from Stigmatella aurantiaca (HYEP_STIAU), which shows only
marginal similarity to the EH family, matches only motifs 5 and 6.
An update on SPTR37_9f identified a true set of 22 sequences, and 133
partial matches.
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| Sequence Titles | HALO_XANAU HALOALKANE DEHALOGENASE (EC 3.8.1.5) - XANTHOBACTER AUTOTROPHICUS.
HYEP_HUMAN EPOXIDE HYDROLASE (EC 3.3.2.3) (MICROSOMAL EPOXIDE HYDROLASE) (EPOXIDE HYDRATASE) - HOMO SAPIENS (HUMAN).
HYEP_RABIT EPOXIDE HYDROLASE (EC 3.3.2.3) (MICROSOMAL EPOXIDE HYDROLASE) (EPOXIDE HYDRATASE) - ORYCTOLAGUS CUNICULUS (RABBIT).
HYEP_RAT EPOXIDE HYDROLASE (EC 3.3.2.3) (MICROSOMAL EPOXIDE HYDROLASE) (EPOXIDE HYDRATASE) - RATTUS NORVEGICUS (RAT).
HYES_HUMAN SOLUBLE EPOXIDE HYDROLASE (SEH) (EC 3.3.2.3) (EPOXIDE HYDRATASE) (CYTOSOLIC EPOXIDE HYDROLASE) (CEH) - HOMO SAPIENS (HUMAN).
HYES_MOUSE SOLUBLE EPOXIDE HYDROLASE (SEH) (EC 3.3.2.3) (EPOXIDE HYDRATASE) (CYTOSOLIC EPOXIDE HYDROLASE) (CEH) - MUS MUSCULUS (MOUSE).
HYES_RAT SOLUBLE EPOXIDE HYDROLASE (SEH) (EC 3.3.2.3) (EPOXIDE HYDRATASE) (CYTOSOLIC EPOXIDE HYDROLASE) (CEH) - RATTUS NORVEGICUS (RAT).
O06266 REGION B OF COSMID SCY07H7 - MYCOBACTERIUM TUBERCULOSIS.
O48789 PUTATIVE SOLUBLE EPOXIDE HYDROLASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O49857 ASPARAGINE-BOND SPECIFIC CYSTEINE ENDOPROTEASE - GLYCINE MAX (SOYBEAN).
O81299 T14P8.15 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P79381 EPOXIDE HYDROLASE - SUS SCROFA (PIG).
P97869 MICROSOMAL EPOXIDE HYDROLASE (EC 3.3.2.3) (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) - MUS MUSCULUS (MOUSE).
Q16764 EPOXIDE HYDROLASE (EC 3.3.2.3) (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) - HOMO SAPIENS (HUMAN).
Q25489 JUVENILE HORMONE-SPECIFIC EPOXIDE HYDROLASE (EC 3.3.2.3) (MICROSOMAL EPOXIDE HYDROLASE) (EPOXIDE HYDRATASE) - MANDUCA SEXTA (TOBACCO HAWKMOTH) (TOBACCO HORNWORM).
Q39856 EPOXIDE HYDROLASE - GLYCINE MAX (SOYBEAN).
Q41412 EPOXIDE HYDROLASE - SOLANUM TUBEROSUM (POTATO).
Q41413 EPOXIDE HYDROLASE - SOLANUM TUBEROSUM (POTATO).
Q41414 EPOXIDE HYDROLASE - SOLANUM TUBEROSUM (POTATO).
Q41415 EPOXIDE HYDROLASE - SOLANUM TUBEROSUM (POTATO).
Q42566 ATSEH (EC 3.3.2.3) (EPOXIDE HYDROLASE) (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
Q94806 MICROSOMAL EPOXIDE HYDROLASE - TRICHOPLUSIA NI (CABBAGE LOOPER).
DEH1_MORSP HALOACETATE DEHALOGENASE H-1 (EC 3.8.1.3) - MORAXELLA SP.
O23445 SIMILARITY TO ATSEH - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O33550 BCHO PROTEIN - RHODOBACTER SPHAEROIDES (RHODOPSEUDOMONAS SPHAEROIDES).
O44124 EPOXIDE HYDROLASE - TRICHOPLUSIA NI (CABBAGE LOOPER).
P96811 HYPOTHETICAL 33.8 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
Y0DA_MYCTU HYPOTHETICAL 32.2 KD PROTEIN CY1A11.10 - MYCOBACTERIUM TUBERCULOSIS.
LINB_PSEPA 1,3,4,6-TETRACHLORO-1,4-CYCLOHEXADIENE HYDROLASE (EC 3.8.1.-) (1,4- TCDN CHLOROHYDROLASE) - PSEUDOMONAS PAUCIMOBILIS (SPHINGOMONAS PAUCIMOBILIS).
LUCI_RENRE RENILLA-LUCIFERIN 2-MONOOXYGENASE (EC 1.13.12.5) (RENILLA-TYPE LUCIFERASE) - RENILLA RENIFORMIS (SEA PANSY).
O06576 HYPOTHETICAL 34.7 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O23444 ATSEH HOMOLOG - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O31243 EPOXIDE HYDROLASE (EC 3.3.2.3) (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) - AGROBACTERIUM RADIOBACTER.
O31581 YFHM PROTEIN - BACILLUS SUBTILIS.
O52866 SOLUBLE EPOXIDE HYDROLASE (SEH) (EC 3.3.2.3) (EPOXIDE HYDRATASE) (CYTOSOLIC EPOXIDE HYDROLASE) (EH) - CORYNEBACTERIUM SP.
O66382 ESTERASE2 - ACETOBACTER PASTEURIANUS.
O69638 PUTATIVE EPOXIDE HYDROLASE - MYCOBACTERIUM TUBERCULOSIS.
O86546 PUTATIVE HYDROLASE - STREPTOMYCES COELICOLOR.
P73490 2-HYDROXY-6-OXOHEPTA-2,4-DIENOATE HYDROLASE - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
P73598 HYPOTHETICAL 32.9 KD PROTEIN - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
P95276 HYPOTHETICAL 39.3 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
Q21277 K07C5.5 PROTEIN - CAENORHABDITIS ELEGANS.
Q23068 SIMILAR TO EPOXIDE HYDROLASE - CAENORHABDITIS ELEGANS.
BCHO_RHOCA MAGNESIUM-CHELATASE 30 KD SUBUNIT - RHODOBACTER CAPSULATUS (RHODOPSEUDOMONAS CAPSULATA).
BPA2_STRAU NON-HAEM BROMOPEROXIDASE BPO-A2 (EC 1.11.1.-) (BROMIDE PEROXIDASE) (BPO2) - STREPTOMYCES AUREOFACIENS.
O05119 PUTATIVE GLYCERATE KINASE AND PYRUVATE KINASE (PYKA) GENES, COMPLETE CDS (PYKA) - METHYLOBACTERIUM EXTORQUENS.
O05235 HYPOTHETICAL 31.3 KD PROTEIN - BACILLUS SUBTILIS.
O05863 LIPV PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O06648 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE (EC 3.7.1.-) - PSEUDOMONAS AZELAICA.
O18391 KRAKEN GENE - DROSOPHILA MELANOGASTER (FRUIT FLY).
O23227 HYPOTHETICAL 41.9 KD PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O53321 HYPOTHETICAL 32.1 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O82821 2-HYDROXY-6-OXO-6-(2'-AMINOPHENYL)HEXA-2, 4-DIENOATE HYDROLASE - PSEUDOMONAS STUTZERI (PSEUDOMONAS PERFECTOMARINA).
O82828 ETBD1 - RHODOCOCCUS SP.
O82829 ETBD2 - RHODOCOCCUS SP.
P71702 HYPOTHETICAL 32.1 KD PROTEIN CY21D4.08C - MYCOBACTERIUM TUBERCULOSIS.
P73096 HYPOTHETICAL 31.9 KD PROTEIN - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
P73114 ESTERASE - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
P73115 HYPOTHETICAL 33.2 KD PROTEIN - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
P73384 HYPOTHETICAL 29.7 KD PROTEIN - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
P73482 HYPOTHETICAL 32.8 KD PROTEIN - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
P91141 SIMILAR TO ACETYLTRANSFERASES - CAENORHABDITIS ELEGANS.
P95959 ORF C04020 - SULFOLOBUS SOLFATARICUS.
PRXC_PSEFL NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) (CHLORIDE PEROXIDASE) (CPO-F) (CHLOROPEROXIDASE F) - PSEUDOMONAS FLUORESCENS.
PRXC_STRAU NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) (CHLORIDE PEROXIDASE) (CPO-T) (CHLOROPEROXIDASE T) - STREPTOMYCES AUREOFACIENS.
PRXC_SYNY3 PUTATIVE NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) (CHLORIDE PEROXIDASE) - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
Q18638 C45B11.2 PROTEIN - CAENORHABDITIS ELEGANS.
Q50642 HYPOTHETICAL 33.7 KD PROTEIN CY227.22C - MYCOBACTERIUM TUBERCULOSIS.
Q53042 HALOALKANE DEHALOGENASE - RHODOCOCCUS RHODOCHROUS.
Q54227 MACROTETROLIDE ANTIBIOTIC-RESISTANCE PROTEIN - STREPTOMYCES GRISEUS.
Q55390 HYPOTHETICAL 38.3 KD PROTEIN - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
Q59695 DIHYDROLIPOAMIDE ACETYLTRANSFERASE (EC 2.3.1.12) (DIHYDROLIPOAMIDE S-ACETYLTRANSFERASE) (LIPOATE ACETYLTRANSFERASE) (THIOLTRANSACETYLASE A) - PSEUDOMONAS PUTIDA.
TPES_PSEPU TROPINESTERASE (EC 3.1.1.10) (ATROPINESTERASE) (ATROPINE ACYLHYDROLASE) - PSEUDOMONAS PUTIDA.
YU14_MYCTU PUTATIVE HALOALKANE DEHALOGENASE (EC 3.8.1.5) - MYCOBACTERIUM TUBERCULOSIS.
ACOC_ALCEU PROBABLE DIHYDROLIPOAMIDE ACETYLTRANSFERASE (EC 2.3.1.12) (FAST- MIGRATING PROTEIN) (FMP) - ALCALIGENES EUTROPHUS.
BPHD_BURCE 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE (EC 3.7.1.-) - BURKHOLDERIA CEPACIA (PSEUDOMONAS CEPACIA).
DMPD_PSESP 2-HYDROXYMUCONIC SEMIALDEHYDE HYDROLASE (EC 3.1.1.-) (HMSH) - PSEUDOMONAS SP. (STRAIN CF600).
ESTE_PSEFL ARYLESTERASE (EC 3.1.1.2) (ARYL-ESTER HYDROLASE) - PSEUDOMONAS FLUORESCENS.
LIP1_PSYIM LIPASE 1 PRECURSOR (EC 3.1.1.3) (TRIACYLGLYCEROL LIPASE) - PSYCHROBACTER IMMOBILIS.
LIP3_MORSP LIPASE 3 PRECURSOR (EC 3.1.1.3) (TRIACYLGLYCEROL LIPASE) - MORAXELLA SP.
MHPC_ECOLI 2-HYDROXY-6-KETONONA-2,4-DIENEDIOIC ACID HYDROLASE (EC 3.7.1.-) - ESCHERICHIA COLI.
O05327 2-HYDROXYMUCONIC SEMIALDEHYDE HYDROLASE - PSEUDOMONAS SP.
O06157 HYPOTHETICAL 28.5 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O06338 HYPOTHETICAL 28.2 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O06420 HYPOTHETICAL 28.3 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O06575 HYPOTHETICAL 32.5 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O06734 PUTATIVE - PROBABLE ESTERASE - BACILLUS SUBTILIS.
O07214 HYPOTHETICAL 36.9 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
O14973 PEG1/MEST - HOMO SAPIENS (HUMAN).
O15007 PEG1/MEST GENE MRNA - HOMO SAPIENS (HUMAN).
O22761 HYPOTHETICAL 128.8 KD PROTEIN.
O22975 T19F06.4 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O22977 T19F06.6 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O27948 CARBOXYLESTERASE (EST-3) - ARCHAEOGLOBUS FULGIDUS.
O28567 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOIC ACID HYDROLASE (PCBD) - ARCHAEOGLOBUS FULGIDUS.
O28735 CARBOXYLESTERASE (EST-2) - ARCHAEOGLOBUS FULGIDUS.
O29396 CARBOXYLESTERASE (EST-1) - ARCHAEOGLOBUS FULGIDUS.
O31266 1H-3-HYDROXY-4-OXOQUINALDINE 2,4-DIOXYGENASE - ARTHROBACTER SP.
O31386 B-KETOADIPATE ENOL-LACTONE HYDROLASE (EC 3.1.1.24) (3-OXOADIPATE ENOL-LACTONASE) (CARBOXYMETHYLBUTENOLIDE LACTONASE) - BRADYRHIZOBIUM JAPONICUM.
O32873 HYPOTHETICAL 31.8 KD PROTEIN - MYCOBACTERIUM LEPRAE.
O32958 OXIDOREDUCTASE - MYCOBACTERIUM LEPRAE.
O33745 THIOSTERASE - STREPTOMYCES SP.
O33766 2-HYDROXYMUCONIC SEMIALDEHYDE HYDROLASE - SPHINGOMONAS SP.
O34312 YTXM - BACILLUS SUBTILIS.
O41892 POLYPROTEIN PRECURSOR - HEPATITIS GB VIRUS A.
O51858 2-HYDROXY-6-OXO-7-METHYLOCTA-2,4-DIENOATE HYDROLASE - PSEUDOMONAS PUTIDA.
O52809 PCZA361.30 - AMYCOLATOPSIS ORIENTALIS.
O54172 HYDROLASE - STREPTOMYCES COELICOLOR.
O60135 FATTY ACID COA LIGASE - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O66664 HYPOTHETICAL 29.5 KD PROTEIN - AQUIFEX AEOLICUS.
O67895 HYPOTHETICAL 23.9 KD PROTEIN - AQUIFEX AEOLICUS.
O67982 3-OXOADIPATE ENOL-LACTONE HYDROLASE/4-CARBOXYMUCONOLACTONE DECARBOXYLASE (EC 3.1.1.24) (3-OXOADIPATE ENOL-LACTONASE) (CARBOXYMETHYLBUTENOLIDE LACTONASE) - RHODOCOCCUS OPACUS.
O69263 2-HYDROXY-6-OXO-2,4-HEPTADIENOATE HYDROLASE - BURKHOLDERIA SP.
O69356 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE - RHODOCOCCUS ERYTHROPOLIS.
O69794 2-HYDROXY-6-OXOHEPTA-2,4-DIENOATE HYDROLASE - RALSTONIA SP.
O73957 LIPOLYTIC ENZYME - SULFOLOBUS ACIDOCALDARIUS.
O85289 HYDROLASE - SPHINGOMONAS SP. CB3.
O85736 NOND - STREPTOMYCES GRISEUS SUBSP. GRISEUS.
O85983 2-HYDROXYMUCONIC SEMIALDEHYDE HYDROLASE - SPHINGOMONAS AROMATICIVORANS.
O86787 HYPOTHETICAL 44.0 KD PROTEIN - STREPTOMYCES COELICOLOR.
O86901 HYDROLASE, DXNB PROTEIN - SPHINGOMONAS SP.
O87637 LACTONE-SPECIFIC ESTERASE - PSEUDOMONAS FLUORESCENS.
O88499 SARCOSINE DEHYDROGENASE (EC 1.5.99.1) - RATTUS NORVEGICUS (RAT).
P91143 SIMILAR TO ACETYLTRANSFERASES - CAENORHABDITIS ELEGANS.
P93732 PROLINE IMINOPEPTIDASE - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
P96446 EXPA5 - SINORHIZOBIUM MELILOTI.
P96688 CARBOXYLESTERASE NP - BACILLUS SUBTILIS.
P96851 HYPOTHETICAL 31.9 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
PHAB_PSEOL POLY(3-HYDROXYALKANOATE) DEPOLYMERASE (EC 3.1.1.-) (PHA DEPOLYMERASE) (PHB DEPOLYMERASE) - PSEUDOMONAS OLEOVORANS.
PIP_NEIGO PROLINE IMINOPEPTIDASE (EC 3.4.11.5) (PROLYL AMINOPEPTIDASE) - NEISSERIA GONORRHOEAE.
PLDB_HAEIN PROBABLE LYSOPHOSPHOLIPASE L2 (EC 3.1.1.5) (LECITHINASE B) - HAEMOPHILUS INFLUENZAE.
PRXC_PSEPY NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) (CHLORIDE PEROXIDASE) (CPO-P) (CHLOROPEROXIDASE P) - PSEUDOMONAS PYRROCINIA.
PRXC_STRLI NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) (CHLORIDE PEROXIDASE) (CPO-L) (CHLOROPEROXIDASE L) - STREPTOMYCES LIVIDANS.
Q07646 PEG1/MEST PROTEIN - MUS MUSCULUS (MOUSE).
Q21147 SIMILAR TO EPOXIDE HYDROLASE - CAENORHABDITIS ELEGANS.
Q45289 GLUTARYL 7-ACA ACYLASE PRECURSOR - BREVIBACILLUS LATEROSPORUS.
Q47858 HRCO, HRCP, HRCQ, HRCR, HRCS, HRCT & HRCU GENES - ERWINIA HERBICOLA.
Q49926 TPEA - MYCOBACTERIUM LEPRAE.
Q52011 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOIC ACID HYDROLASE - PSEUDOMONAS PSEUDOALCALIGENES.
Q52036 2-HYDROXY-6-PHENYLHEXA-2 - PSEUDOMONAS PUTIDA.
Q52532 PCBD - PSEUDOMONAS SP.
Q52897 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE (EC 3.7.1.-) (HOPD HYDROLASE) - RHODOCOCCUS SP.
Q53540 ESTERASE - PSEUDOMONAS PUTIDA.
Q59093 3-OXOADIPATE ENOL-LACTONASE I (EC 3.1.1.24) (ENOL-LACTONE HYDROLASE I) (BETA-KETOADIPATE ENOL-LACTONE HYDROLASE I) - ACINETOBACTER CALCOACETICUS.
Q59248 CARBOXYLESTERASE NP (EC 3.1.1.1) (ALI-ESTERASE) (B-ESTERASE) (MONOBUTYRASE) (COCAINE ESTERASE) (PROCAINE ESTERASE) (METHYLBUTYRASE) - BACILLUS SUBTILIS.
Q59324 BETA-D-GALACTOSIDASE (EC 3.2.1.23) (BETA-GALACTOSIDASE) (LACTASE) - COMAMONAS TESTOSTERONI (PSEUDOMONAS TESTOSTERONI).
Q92571 MEST PROTEIN - HOMO SAPIENS (HUMAN).
RRPL_MUMPM RNA POLYMERASE BETA SUBUNIT (EC 2.7.7.48) (LARGE STRUCTURAL PROTEIN) (L PROTEIN) - MUMPS VIRUS (STRAIN MIYAHARA VACCINE).
THCF_RHOER NON-HEME HALOPEROXIDASE (EC 1.11.1.-) - RHODOCOCCUS ERYTHROPOLIS.
TODF_PSEPU 2-HYDROXY-6-OXO-2,4-HEPTADIENOATE HYDROLASE (HOHH) (EC 3.1.1.-) - PSEUDOMONAS PUTIDA.
XYLF_PSEPU 2-HYDROXYMUCONIC SEMIALDEHYDE HYDROLASE (EC 3.1.1.-) (HMSH) - PSEUDOMONAS PUTIDA.
Y00P_MYCTU PROBABLE OXIDOREDUCTASE EPHD (EC 1.-.-.-) - MYCOBACTERIUM TUBERCULOSIS.
Y0D9_MYCTU HYPOTHETICAL 31.7 KD PROTEIN CY1A11.09C - MYCOBACTERIUM TUBERCULOSIS.
YHN5_YEAST HYPOTHETICAL 44.9 KD PROTEIN IN ERG7-NMD2 INTERGENIC REGION - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
YN93_YEAST HYPOTHETICAL 32.8 KD PROTEIN IN BIO3-HXT17 INTERGENIC REGION - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
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