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PR00405

Identifier
REVINTRACTNG  [View Relations]  [View Alignment]  
Accession
PR00405
No. of Motifs
3
Creation Date
14-DEC-1995  (UPDATE 29-JUL-1999)
Title
HIV Rev interacting protein signature
Database References

INTERPRO; IPR001164
Literature References
1. FRITZ, C.C., ZAPP, M.L. AND GREEN, M.R.
A human nucleoporin-like protein that specifically interacts with HIV Rev.
NATURE 376 530-533 (1995).

Documentation
The Rev protein of human immunodeficiency virus type 1 (HIV-1) facilitates
nuclear export of unspliced and partly-spliced viral RNAs [1]. Rev contains
an RNA-binding domain and an effector domain; the latter is believed to 
interact with a cellular cofactor required for the Rev response and hence
HIV-1 replication [1]. Human Rev interacting protein (hRIP) specifically
interacts with the Rev effector. The amino acid sequence of hRIP is 
characterised by an N-terminal, C-4 class zinc finger motif.
 
REVINTRACTNG is a 3-element fingerprint that provides a signature for the
hRIP family of zinc finger proteins. The fingerprint was derived from an
initial alignment of 7 sequences: the motifs span the full zinc finger
domain. Two iterations on OWL26.3 were required to reach convergence, at
which point a true set comprising 12 sequences was identified. Three
partial matches were also found, all of which match motif 2, but fail to
make significant matches with either motifs 1 or 3.
 
An update on SPTR37_9f identified a true set of 29 sequences, and 1
partial match.
Summary Information
  29 codes involving  3 elements
1 codes involving 2 elements
Composite Feature Index
3292929
2011
123
True Positives
GCS1_YEAST    GLO3_YEAST    GTS1_YEAST    NUPL_HUMAN    
O02753 O02780 O04097 O18181
O18358 O43150 O49557 O49688
O64666 O74345 O77092 O80925
O82171 O82484 O88768 P90904
Q62848 Q63629 SP18_YEAST Y050_HUMAN
Y148_HUMAN Y167_HUMAN YDBH_SCHPO YIE4_YEAST
YQP4_CAEEL
True Positive Partials
Codes involving 2 elements
YAUA_SCHPO
Sequence Titles
GCS1_YEAST  ZINC FINGER PROTEIN GCS1 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). 
GLO3_YEAST ZINC FINGER PROTEIN GLO3 - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
GTS1_YEAST GTS1 PROTEIN (LSR1 PROTEIN) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
NUPL_HUMAN NUCLEOPORIN-LIKE PROTEIN RIP (REV INTERACTING PROTEIN) (REV/REX ACTIVATION DOMAIN-BINDING PROTEIN) - HOMO SAPIENS (HUMAN).
O02753 PHOSPHATIDYLINOSITOL-3,4,5-TRIPHOSPHATE BINDING PROTEIN (PTDINS(3,4,5)P3-BINDING PROTEIN) - BOS TAURUS (BOVINE).
O02780 INOSITOL(1,3,4,5)TETRAKISPHOSPHATE RECEPTOR - SUS SCROFA (PIG).
O04097 BRCA1-ASSOCIATED RING DOMAIN PROTEINISOLOG - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O18181 W09D10.1 PROTEIN - CAENORHABDITIS ELEGANS.
O18358 PUTATIVE ARF1 GTPASE ACTIVATING PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
O43150 KIAA0400 - HOMO SAPIENS (HUMAN).
O49557 HYPOTHETICAL 41.0 KD PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O49688 HYPOTHETICAL 120.4 KD PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O64666 F22O13.17 - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O74345 PUTATIVE TRANSCRIPTION FACTOR OF THE GCS1-GLO3-SPS18 FAMILY - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
O77092 ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN - PLASMODIUM BERGHEI YOELII.
O80925 PUTATIVE ARF1 GTPASE ACTIVATING PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O82171 T4C15.12 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O82484 T12H20.8 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
O88768 IP4/PIP3 BINDING PROTEIN - RATTUS NORVEGICUS (RAT).
P90904 K02B12.7 PROTEIN - CAENORHABDITIS ELEGANS.
Q62848 ADP-RIBOSYLATION FACTOR 1-DIRECTED GTPASE ACTIVATING PROTEIN - RATTUS NORVEGICUS (RAT).
Q63629 CENTAURIN ALPHA - RATTUS NORVEGICUS (RAT).
SP18_YEAST SPORULATION PROTEIN SPS18 (SPORULATION-SPECIFIC PROTEIN SPX18) - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
Y050_HUMAN HYPOTHETICAL PROTEIN KIAA0050 - HOMO SAPIENS (HUMAN).
Y148_HUMAN HYPOTHETICAL PROTEIN KIAA0148 - HOMO SAPIENS (HUMAN).
Y167_HUMAN HYPOTHETICAL PROTEIN KIAA0167 - HOMO SAPIENS (HUMAN).
YDBH_SCHPO HYPOTHETICAL 53.0 KD PROTEIN C22E12.17C IN CHROMOSOME I - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
YIE4_YEAST HYPOTHETICAL 32.6 KD PROTEIN IN MET30-PIG2 INTERGENIC REGION - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
YQP4_CAEEL HYPOTHETICAL 127.4 KD PROTEIN F07F6.4 IN CHROMOSOME III - CAENORHABDITIS ELEGANS.

YAUA_SCHPO HYPOTHETICAL 104.5 KD PROTEIN C26A3.10 IN CHROMOSOME I - SCHIZOSACCHAROMYCES POMBE (FISSION YEAST).
Scan History
OWL26_3    2  200  NSINGLE    
SPTR37_9f 4 100 NSINGLE
Initial Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
NRVCFDCGNKNPTWTSVPFG GLO3_YEAST 28 28 -
NKKCMDCGAPNPQWATPKFG GCS1_YEAST 23 23 -
NNNCFECKSVNPQFVSCSFG SX18_YEAST 25 25 -
NRKCFDCDQRGPTYVNMTVG HSRNANLP 26 26 -
NRKCFDCDQRGPTYVNMTVG HUMRABCCF 26 26 -
NASCCDCGLADPRWASINLG HUMORFV 265 265 -
NAQCCDCREPAPEWASINLG HUMORFKG1K 417 417 -

Motif 2 width=18
Element Seqn Id St Int Rpt
GSFVCTSCSGSLRGLNPP HUMRABCCF 45 -1 -
GAFICLECAGIHRGLGVH GCS1_YEAST 42 -1 -
GVMLCIQCSAVHRNMGVH GLO3_YEAST 47 -1 -
GSFVCTSCSGSLRGLNPP HSRNANLP 45 -1 -
GIFICVNCANLLRGMGTN SX18_YEAST 44 -1 -
GITLCIECSGIHRSLGVH HUMORFV 284 -1 -
GVTLCIQCSGIHRSLGVH HUMORFKG1K 436 -1 -

Motif 3 width=22
Element Seqn Id St Int Rpt
VKSSTLDKWTINNLRRFKLGGN GLO3_YEAST 68 3 -
VKSITMDNFEEKDVRRVEKSGN SX18_YEAST 65 3 -
VKSISMTTFTQQEIEFLQKHGN HSRNANLP 65 2 -
VKSISMTTFTQQEIEFLQKHGN HUMRABCCF 65 2 -
VRSLTLDTWEPELLKLMCELGN HUMORFV 305 3 -
VRSLTLDSWEPELVKLMCELGN HUMORFKG1K 457 3 -
VRSITMDQFKPEELLRMEKGGN GCS1_YEAST 63 3 -
Final Motifs
Motif 1  width=20
Element Seqn Id St Int Rpt
NNVCFECGAFNPQWVSVTYG Q62848 19 19 -
NKVCFDCSAKNPTWASVTYG O49688 25 25 -
NKICFDCNAKNPTWASVTYG O82171 22 22 -
NSKCFECGTHNPQWVSVTYG O18358 19 19 -
NNFCFECEANNPQWVSVSYG P90904 19 19 -
NKVCVDCSQKNPQWASISYG O80925 16 16 -
NNKCFDCGIPNPDWVSVNHG O77092 19 19 -
NARCADCGAPDPDWASYTLG O02753 18 18 -
NSRCADCGAPDPDWASYTLG Q63629 18 18 -
NSRCADCGAPDPDWASYTLG O88768 18 18 -
NAHCADCGAPDPDWASYTLG O02780 18 18 -
NKYCADCQAKTPRWAAWNLG O18181 29 29 -
NKKCMDCGAPNPQWATPKFG GCS1_YEAST 23 23 -
NAQCCDCREPAPEWASINLG Y050_HUMAN 417 417 -
NSICVDCGAPNPTWASLNLG Y167_HUMAN 587 587 -
NKVCFDCGAKNPTWSSTTFG YDBH_SCHPO 21 21 -
NRVCFDCGNKNPTWTSVPFG GLO3_YEAST 28 28 -
NNLCADCSTRGVQWASWNLG O74345 20 20 -
NDVCCDCGAPDPTWLSTNLG O43150 433 433 -
NRVCADCGAPDPKWALIECY O49557 27 27 -
NKLCFDCGARNPTWCTVTYG YQP4_CAEEL 25 25 -
NNACAECNAPEPDWASLNLG O04097 235 235 -
SHCADCKAQLHPRWASWSLG YIE4_YEAST 21 21 -
SEVCADCSGPDPSWASVNRG Y148_HUMAN 8 8 -
ANKCGECGNFYPTWCSVNLG GTS1_YEAST 27 27 -
NNNCFECKSVNPQFVSCSFG SP18_YEAST 25 25 -
NRKCFDCDQRGPTYVNMTVG NUPL_HUMAN 26 26 -
NRRCINCNSLGPQYVCTTFW O64666 24 24 -
VRSCFQYCALYPEDYSIKKY O82484 405 405 -

Motif 2 width=18
Element Seqn Id St Int Rpt
GIWICLECSGRHRGLGVH Q62848 38 -1 -
GIFLCIDCSATHRNLGVH O49688 44 -1 -
GIFLCIDCSAVHRSLGVH O82171 41 -1 -
GIWICLECSGKHRSLGVH O18358 38 -1 -
GIWICLECSGIHRSLGVH P90904 38 -1 -
GIFMCLECSGKHRGLGVH O80925 35 -1 -
GIFLCINCSGVHRSLGVH O77092 38 -1 -
GVFICLSCSGIHRNIPHV O02753 37 -1 -
GVFICLSCSGIHRNIPQV Q63629 37 -1 -
GVFICLSCSGIHRNIPQV O88768 37 -1 -
GVFICLSCSGIHRNIPQV O02780 37 -1 -
GVFICIRCAGIHRNLGVH O18181 48 -1 -
GAFICLECAGIHRGLGVH GCS1_YEAST 42 -1 -
GVTLCIQCSGIHRSLGVH Y050_HUMAN 436 -1 -
GALICIECSGIHRNLGTH Y167_HUMAN 606 -1 -
GIYLCLDCSAAHRNMGVH YDBH_SCHPO 40 -1 -
GVMLCIQCSAVHRNMGVH GLO3_YEAST 47 -1 -
GIFLCLRCATIHRKLGTH O74345 39 -1 -
GILTCIECSGIHRELGVH O43150 452 -1 -
GVFICLKCCGVHRSLGSH O49557 78 31 -
GVFLCIDCSAVHRNLGVH YQP4_CAEEL 44 -1 -
GVLLCIQCSGVHRNLGVH O04097 254 -1 -
GVFICIKCAGIHRSLGTH YIE4_YEAST 40 -1 -
GTFLCDECCSVHRSLGRH Y148_HUMAN 27 -1 -
GVFLCGRCASVHRKVFGS GTS1_YEAST 46 -1 -
GIFICVNCANLLRGMGTN SP18_YEAST 44 -1 -
GSFVCTSCSGSLRGLNPP NUPL_HUMAN 45 -1 -
WTFVCMACSGIHREFTHR O64666 43 -1 -
GSIAGISKLSSLRTLGLR O82484 622 197 -

Motif 3 width=22
Element Seqn Id St Int Rpt
VRSVTMDKWKDIELEKMKAGGN Q62848 59 3 -
VRSTNLDSWSPEQLRTMMFGGN O49688 65 3 -
VRSTNLDSWSSEQLKMMIYGGN O82171 62 3 -
VRSVTMDKWKDIELEKMKAGGN O18358 59 3 -
VRSVTMDKWKDIELAKMKAGGN P90904 59 3 -
VRSVTMDSWSEIQIKKMDAGGN O80925 56 3 -
VRSIKMDIFTDEQLKYMDKGGN O77092 59 3 -
VKSVRLDTWEDVQVEFMASRGN O02753 57 2 -
VKSVRLDAWDETQVEFMTSHGN Q63629 57 2 -
VKSVRLDAWDETQVEFMTSHGN O88768 57 2 -
VKSVRLDTWEEPQVEFMASRGN O02780 57 2 -
VRSVNLDSWTPEQVQTMRVMGN O18181 69 3 -
VRSITMDQFKPEELLRMEKGGN GCS1_YEAST 63 3 -
VRSLTLDSWEPELVKLMCELGN Y050_HUMAN 457 3 -
VRSLDLDDWPRELTLVLTAIGN Y167_HUMAN 627 3 -
LRSTVLDSWTYAQLRVMRVGGN YDBH_SCHPO 64 6 -
VKSSTLDKWTINNLRRFKLGGN GLO3_YEAST 68 3 -
VKSISLDEWSNDQIEKMKHWGN O74345 60 3 -
MQSLTLDVLGTSELLLAKNIGN O43150 473 3 -
VLSVTLDEWSDEEVDSMIEIGG O49557 99 3 -
VRSTNLDTNWTWLQLRAMQLGG YQP4_CAEEL 65 3 -
SLSLDVKVWEPTILDLFRNLGN O04097 277 5 -
VKSVDLDTWKEEHLVKLIQFKN YIE4_YEAST 61 3 -
VRHLKHTPWPPTLLQMVETLYN Y148_HUMAN 48 3 -
VKSLSMDRWTREDIDELVSLGG GTS1_YEAST 72 8 -
VKSITMDNFEEKDVRRVEKSGN SP18_YEAST 65 3 -
VKSISMTTFTQQEIEFLQKHGN NUPL_HUMAN 65 2 -
VKSVSMSKFTSKEVEVLQNGGN O64666 61 0 -
LRSLTMWNCEISEIEIERLTWN O82484 711 71 -